## Thu Nov 14 23:20:43 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin1/DTH_2_bin.41.fa -m mmseqs --itype genome -o DTH_2_bin.41 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/DTH_2_bin.41 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
DTH2_k127_10020972_0	554065.XP_005848006.1	4.493e-14	79.0	2CMDV@1|root,2QQ2D@2759|Eukaryota,37IGY@33090|Viridiplantae,34K6K@3041|Chlorophyta	3041|Chlorophyta	U	leucine-rich repeat extensin-like protein	-	-	-	ko:K14709	-	-	-	-	ko00000,ko02000	2.A.5.1,2.A.5.3,2.A.5.6	-	-	PKD_channel
DTH2_k127_10029041_6	240302.BN982_00147	1.769e-07	61.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,3NDEJ@45667|Halobacillus	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
DTH2_k127_10029041_3	1238450.VIBNISOn1_280048	5.482e-86	296.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1XUZV@135623|Vibrionales	135623|Vibrionales	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH2_k127_10029041_2	572547.Amico_1664	7.401e-97	331.0	COG3875@1|root,COG3875@2|Bacteria,3TC3R@508458|Synergistetes	508458|Synergistetes	S	Domain of unknown function (DUF2088)	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
DTH2_k127_10029041_4	400668.Mmwyl1_2785	1.988e-25	117.0	COG2186@1|root,COG2186@2|Bacteria,1MUP9@1224|Proteobacteria,1RNPJ@1236|Gammaproteobacteria,1XHEX@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	ko:K13637	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
DTH2_k127_10029041_1	420246.GTNG_1271	5.116e-126	419.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1WG7T@129337|Geobacillus	91061|Bacilli	C	Aldehyde dehydrogenase family	aldHT_2	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
DTH2_k127_10029041_0	1007105.PT7_3435	4.319e-196	635.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2W0PN@28216|Betaproteobacteria,3T5HV@506|Alcaligenaceae	28216|Betaproteobacteria	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh,Transket_pyr,Transketolase_C
DTH2_k127_10029041_5	886293.Sinac_1635	1.092e-08	58.0	COG0582@1|root,COG0582@2|Bacteria,2IYXX@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
DTH2_k127_10036361_2	398767.Glov_3376	1.705e-50	201.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1PDFN@1224|Proteobacteria,42ZMI@68525|delta/epsilon subdivisions,2WUWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH2_k127_10036361_0	941449.dsx2_1128	8.461e-73	268.0	COG1216@1|root,COG1216@2|Bacteria,1RGUZ@1224|Proteobacteria,42SZI@68525|delta/epsilon subdivisions,2X8C2@28221|Deltaproteobacteria,2MHG5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_11
DTH2_k127_10036361_4	1535422.ND16A_1852	1.081e-30	122.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SWYX@1236|Gammaproteobacteria,2Q8BC@267889|Colwelliaceae	1236|Gammaproteobacteria	K	Ribonuclease B OB domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD
DTH2_k127_10036361_1	1209989.TepiRe1_2032	1.804e-53	200.0	COG2116@1|root,COG2116@2|Bacteria,1TRTT@1239|Firmicutes,24BU5@186801|Clostridia,42G5C@68295|Thermoanaerobacterales	186801|Clostridia	P	Formate nitrite family of	fdhC	-	-	ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2	-	-	Form_Nir_trans
DTH2_k127_10036361_3	443152.MDG893_01785	1.5e-49	184.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,46459@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
DTH2_k127_10054383_2	1304875.JAFZ01000001_gene1936	2.771e-82	295.0	COG1269@1|root,COG1269@2|Bacteria,3T9PG@508458|Synergistetes	508458|Synergistetes	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DTH2_k127_10054383_4	1294142.CINTURNW_0931	1.108e-35	141.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,36I1J@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the V-ATPase proteolipid subunit family	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
DTH2_k127_10054383_6	1209989.TepiRe1_2241	3.503e-23	106.0	COG1390@1|root,COG1390@2|Bacteria,1VEEA@1239|Firmicutes,24QMH@186801|Clostridia,42GQA@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
DTH2_k127_10054383_5	1443122.Z958_06690	3.102e-33	141.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,36DZ2@31979|Clostridiaceae	186801|Clostridia	C	C subunit	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DTH2_k127_10054383_7	572547.Amico_0806	0.0004646	47.0	COG1436@1|root,COG1436@2|Bacteria,3TBMU@508458|Synergistetes	508458|Synergistetes	C	PFAM Vacuolar H transporting two-sector ATPase F subunit	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
DTH2_k127_10054383_0	555088.DealDRAFT_1679	9.132e-235	739.0	COG1155@1|root,COG1155@2|Bacteria,1UIKB@1239|Firmicutes	1239|Firmicutes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
DTH2_k127_10054383_1	994573.T472_0215070	1.334e-217	683.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,36DRP@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DTH2_k127_10054383_3	1121344.JHZO01000006_gene1909	2.09e-44	168.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,3WHIG@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
DTH2_k127_1046739_1	1168034.FH5T_01525	4.914e-67	237.0	COG0438@1|root,COG0438@2|Bacteria,4P10Z@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
DTH2_k127_1046739_0	207559.Dde_0965	2.083e-112	373.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2M7S1@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
DTH2_k127_1075970_0	748449.Halha_1207	1.462e-149	492.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WA9E@53433|Halanaerobiales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
DTH2_k127_1075970_1	880073.Calab_0113	3.784e-93	328.0	COG0168@1|root,COG0168@2|Bacteria,2NNW1@2323|unclassified Bacteria	2|Bacteria	P	Cation transport protein	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
DTH2_k127_1075970_4	562970.Btus_2304	8.005e-50	185.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,4HBPH@91061|Bacilli,27APN@186823|Alicyclobacillaceae	91061|Bacilli	P	TrkA-C domain	ktrA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DTH2_k127_1075970_2	211165.AJLN01000066_gene4475	2.9e-64	230.0	COG0561@1|root,COG0561@2|Bacteria,1GDI4@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
DTH2_k127_1075970_3	714961.BFZC1_17334	7.559e-54	194.0	COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,4HD3B@91061|Bacilli,3IX32@400634|Lysinibacillus	91061|Bacilli	E	Carboxynorspermidine decarboxylase	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
DTH2_k127_107914_1	237368.SCABRO_01903	4.414e-111	367.0	COG0462@1|root,COG0462@2|Bacteria,2IXI0@203682|Planctomycetes	203682|Planctomycetes	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
DTH2_k127_107914_4	1123508.JH636445_gene6804	7.184e-33	135.0	COG1825@1|root,COG1825@2|Bacteria,2J050@203682|Planctomycetes	203682|Planctomycetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
DTH2_k127_107914_2	575540.Isop_2892	4.98e-51	187.0	COG0193@1|root,COG0193@2|Bacteria,2IZXT@203682|Planctomycetes	203682|Planctomycetes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
DTH2_k127_107914_6	1142394.PSMK_16180	1.937e-16	85.0	COG0360@1|root,COG0360@2|Bacteria,2J0U0@203682|Planctomycetes	203682|Planctomycetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
DTH2_k127_107914_3	237368.SCABRO_01907	4.483e-38	147.0	COG0629@1|root,COG0629@2|Bacteria,2IZJ8@203682|Planctomycetes	203682|Planctomycetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
DTH2_k127_107914_7	1540257.JQMW01000011_gene2385	1.168e-14	76.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,36KGE@31979|Clostridiaceae	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
DTH2_k127_107914_5	1142394.PSMK_16160	2.605e-28	120.0	COG0359@1|root,COG0359@2|Bacteria,2IZCC@203682|Planctomycetes	203682|Planctomycetes	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
DTH2_k127_107914_0	1142394.PSMK_13120	1.778e-137	451.0	COG0305@1|root,COG0305@2|Bacteria,2IXJT@203682|Planctomycetes	203682|Planctomycetes	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
DTH2_k127_1082943_0	1047013.AQSP01000142_gene235	4.753e-61	215.0	COG1063@1|root,COG1063@2|Bacteria,2NPFX@2323|unclassified Bacteria	2|Bacteria	E	Glucose dehydrogenase C-terminus	ydjJ	-	1.1.1.14,1.1.1.9	ko:K00008,ko:K05351	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH2_k127_1087268_1	521674.Plim_3728	1.092e-274	880.0	COG1197@1|root,COG1197@2|Bacteria,2IWV4@203682|Planctomycetes	203682|Planctomycetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
DTH2_k127_1087268_3	521674.Plim_2612	2.775e-98	331.0	COG2222@1|root,COG2222@2|Bacteria,2J1SP@203682|Planctomycetes	203682|Planctomycetes	M	sugar isomerase	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1087268_2	744872.Spica_2651	2.875e-261	824.0	COG1208@1|root,COG1208@2|Bacteria,2J5V0@203691|Spirochaetes	203691|Spirochaetes	JM	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
DTH2_k127_1087268_0	56780.SYN_02383	2.796e-315	987.0	COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MR7X@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
DTH2_k127_1087268_4	744872.Spica_0934	2.853e-77	261.0	COG0334@1|root,COG0334@2|Bacteria,2J5DD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdh	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DTH2_k127_1103423_0	1303518.CCALI_01287	0.0	1164.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
DTH2_k127_1103423_1	1280706.AUJE01000015_gene1583	6.007e-37	149.0	COG1349@1|root,COG1349@2|Bacteria,1UZ6T@1239|Firmicutes,4H2GZ@909932|Negativicutes	909932|Negativicutes	K	DeoR C terminal sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
DTH2_k127_1103423_2	1094491.BBbe_05000	4.773e-15	83.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,48TGM@772|Bartonellaceae	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DTH2_k127_1129159_0	1121936.AUHI01000014_gene16	2.814e-104	346.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,4H9YT@91061|Bacilli	91061|Bacilli	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DTH2_k127_1129159_3	1210884.HG799469_gene14231	9.56e-73	254.0	COG0020@1|root,COG0020@2|Bacteria,2IX6Z@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
DTH2_k127_1129159_7	1122994.AUFR01000010_gene2287	1.782e-30	131.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4DQ6M@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
DTH2_k127_1129159_1	1142394.PSMK_17530	1.573e-93	316.0	COG1702@1|root,COG1702@2|Bacteria,2IXBB@203682|Planctomycetes	203682|Planctomycetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
DTH2_k127_1129159_2	886293.Sinac_6812	2.429e-93	325.0	COG1480@1|root,COG1480@2|Bacteria,2IYP7@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
DTH2_k127_1129159_9	886293.Sinac_6813	5.562e-14	78.0	COG0319@1|root,COG0319@2|Bacteria,2J0MV@203682|Planctomycetes	203682|Planctomycetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
DTH2_k127_1129159_5	756272.Plabr_1325	4.91e-71	256.0	COG1253@1|root,COG1253@2|Bacteria,2IZAU@203682|Planctomycetes	203682|Planctomycetes	S	COG1253 Hemolysins and related	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
DTH2_k127_1129159_8	1123508.JH636445_gene6737	6.253e-26	116.0	COG1381@1|root,COG1381@2|Bacteria,2IZU9@203682|Planctomycetes	203682|Planctomycetes	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
DTH2_k127_1129159_6	583355.Caka_1113	4.966e-54	198.0	2ERTX@1|root,33JD4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1129159_4	1191523.MROS_1098	1.598e-72	250.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z5669	Cytochrom_C552
DTH2_k127_1193980_4	886293.Sinac_4979	4.3e-58	206.0	COG0440@1|root,COG0440@2|Bacteria,2IZ6Q@203682|Planctomycetes	203682|Planctomycetes	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DTH2_k127_1193980_0	247490.KSU1_D1033	7.301e-210	666.0	COG0028@1|root,COG0028@2|Bacteria,2IXMU@203682|Planctomycetes	203682|Planctomycetes	H	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DTH2_k127_1193980_7	477974.Daud_0998	2.863e-08	65.0	COG4972@1|root,COG4972@2|Bacteria,1V19I@1239|Firmicutes,259B9@186801|Clostridia,262T1@186807|Peptococcaceae	186801|Clostridia	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
DTH2_k127_1193980_6	1142394.PSMK_26930	3.441e-21	100.0	COG3167@1|root,COG3167@2|Bacteria	2|Bacteria	NU	carbon utilization	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
DTH2_k127_1193980_1	1142394.PSMK_26950	4.014e-153	504.0	COG2804@1|root,COG2804@2|Bacteria,2IX4I@203682|Planctomycetes	203682|Planctomycetes	NU	COG2804 Type II secretory pathway ATPase PulE Tfp pilus assembly pathway ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DTH2_k127_1193980_2	1142394.PSMK_25980	6.875e-133	433.0	COG2805@1|root,COG2805@2|Bacteria,2IXRP@203682|Planctomycetes	203682|Planctomycetes	NU	COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DTH2_k127_1193980_3	1142394.PSMK_25970	9.485e-105	352.0	COG1459@1|root,COG1459@2|Bacteria,2IYHA@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DTH2_k127_1193980_8	1142394.PSMK_03080	5.096e-06	55.0	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	ppdC	-	-	ko:K02458,ko:K02671,ko:K02681	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	N_methyl,T2SSppdC
DTH2_k127_1199448_0	411477.PARMER_04360	5.002e-48	194.0	COG3533@1|root,COG3533@2|Bacteria,4NFW3@976|Bacteroidetes,2FRKH@200643|Bacteroidia,22Z9V@171551|Porphyromonadaceae	976|Bacteroidetes	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
DTH2_k127_1227159_1	523850.TON_1819	3.891e-19	101.0	COG4745@1|root,arCOG00562@2157|Archaea,2Y6NZ@28890|Euryarchaeota,244ZB@183968|Thermococci	183968|Thermococci	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DTH2_k127_1227159_0	1317122.ATO12_18925	1.409e-48	180.0	COG1817@1|root,COG1817@2|Bacteria,4NMZC@976|Bacteroidetes,1I9GP@117743|Flavobacteriia,2YHXC@290174|Aquimarina	976|Bacteroidetes	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
DTH2_k127_1234948_3	690850.Desaf_3252	2.757e-44	174.0	COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2M8FS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
DTH2_k127_1234948_0	858215.Thexy_0120	6.077e-113	374.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,42EQX@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 2-nitropropane dioxygenase NPD	-	-	-	-	-	-	-	-	-	-	-	-	NMO
DTH2_k127_1234948_2	247490.KSU1_C0729	3.05e-48	188.0	COG0616@1|root,COG0616@2|Bacteria,2IYKF@203682|Planctomycetes	203682|Planctomycetes	OU	TIGRFAM signal peptide peptidase SppA, 36K type	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
DTH2_k127_1234948_1	795359.TOPB45_0431	5.154e-112	371.0	COG0536@1|root,COG0536@2|Bacteria,2GHPW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
DTH2_k127_1234948_4	269799.Gmet_1986	1.073e-05	53.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,43S2T@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
DTH2_k127_1239795_0	246197.MXAN_2689	3.871e-174	555.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2YTWM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K02474,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DTH2_k127_1239795_3	113355.CM001775_gene380	0.0008324	47.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
DTH2_k127_1239795_2	1499967.BAYZ01000076_gene790	6.106e-26	112.0	COG1895@1|root,COG1895@2|Bacteria	2|Bacteria	O	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
DTH2_k127_1239795_1	192952.MM_1936	4.529e-51	195.0	arCOG02527@1|root,arCOG02527@2157|Archaea,2XZJV@28890|Euryarchaeota,2NA0Y@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1246949_2	247490.KSU1_B0246	1.663e-84	285.0	COG0459@1|root,COG0459@2|Bacteria,2IWZS@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
DTH2_k127_1246949_1	237368.SCABRO_00811	7.451e-85	286.0	COG0060@1|root,COG0060@2|Bacteria,2IWX2@203682|Planctomycetes	203682|Planctomycetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
DTH2_k127_1246949_0	247490.KSU1_C0408	3.578e-183	597.0	COG0060@1|root,COG0060@2|Bacteria,2IWX2@203682|Planctomycetes	203682|Planctomycetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
DTH2_k127_1246949_3	1142394.PSMK_15060	9.888e-17	89.0	COG1215@1|root,COG1215@2|Bacteria,2IZ8G@203682|Planctomycetes	203682|Planctomycetes	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_21
DTH2_k127_1267353_2	497964.CfE428DRAFT_1727	9.448e-07	51.0	COG1064@1|root,COG1064@2|Bacteria	2|Bacteria	P	alcohol dehydrogenase	yjgB	GO:0003674,GO:0003824,GO:0004033,GO:0005488,GO:0008106,GO:0008150,GO:0008152,GO:0008270,GO:0016491,GO:0016614,GO:0016616,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.1	ko:K12957,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH2_k127_1267353_0	756272.Plabr_0466	1.641e-187	596.0	COG0439@1|root,COG0439@2|Bacteria,2IWZV@203682|Planctomycetes	203682|Planctomycetes	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DTH2_k127_1267353_1	1142394.PSMK_21040	1.836e-33	135.0	COG0511@1|root,COG0511@2|Bacteria,2IZJ6@203682|Planctomycetes	203682|Planctomycetes	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
DTH2_k127_1272479_2	234267.Acid_2068	1.311e-33	139.0	COG1609@1|root,COG1609@2|Bacteria,3Y2ZZ@57723|Acidobacteria	57723|Acidobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
DTH2_k127_1272479_3	1168034.FH5T_11210	1.467e-29	124.0	COG1451@1|root,COG1451@2|Bacteria,4NNY6@976|Bacteroidetes,2FPFA@200643|Bacteroidia	976|Bacteroidetes	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
DTH2_k127_1272479_0	1499967.BAYZ01000009_gene5389	9.817e-159	511.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_1272479_1	1191523.MROS_0349	2.846e-155	496.0	COG0148@1|root,COG0148@2|Bacteria	2|Bacteria	G	phosphopyruvate hydratase activity	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DTH2_k127_127610_6	1209072.ALBT01000008_gene2901	9.352e-09	64.0	2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria,1FGM3@10|Cellvibrio	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
DTH2_k127_127610_3	1144275.COCOR_01446	1.759e-179	577.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2YZUW@29|Myxococcales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
DTH2_k127_127610_4	1123242.JH636434_gene3589	3.937e-124	407.0	COG0845@1|root,COG0845@2|Bacteria,2IZ0Q@203682|Planctomycetes	203682|Planctomycetes	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
DTH2_k127_127610_0	1123242.JH636434_gene3590	0.0	1475.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,2IWZA@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
DTH2_k127_127610_2	1144275.COCOR_01443	1.52e-186	589.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,43AEH@68525|delta/epsilon subdivisions,2WIU2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	yhhJ	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DTH2_k127_127610_1	645991.Sgly_1049	0.0	1298.0	COG0376@1|root,COG0376@2|Bacteria,1TQDA@1239|Firmicutes,24DM7@186801|Clostridia,260RF@186807|Peptococcaceae	186801|Clostridia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
DTH2_k127_127610_5	1168289.AJKI01000010_gene1545	2.842e-44	168.0	COG0383@1|root,COG0383@2|Bacteria,4NJ12@976|Bacteroidetes,2FNHX@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 38 C-terminal domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,F5_F8_type_C,Glyco_hydro_38,Glyco_hydro_38C
DTH2_k127_1283690_1	270374.MELB17_14591	0.0008243	50.0	COG1938@1|root,COG1938@2|Bacteria,1NY9I@1224|Proteobacteria,1T2RJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	DUF1194,VPEP
DTH2_k127_1283690_0	1449126.JQKL01000013_gene3399	1.019e-19	104.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,269N4@186813|unclassified Clostridiales	186801|Clostridia	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DTH2_k127_1290287_1	237368.SCABRO_03516	1.081e-36	147.0	COG1519@1|root,COG1519@2|Bacteria,2IYCJ@203682|Planctomycetes	203682|Planctomycetes	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
DTH2_k127_1290287_0	1121918.ARWE01000001_gene3119	9.72e-143	466.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WJ1M@28221|Deltaproteobacteria,43S7W@69541|Desulfuromonadales	68525|delta/epsilon subdivisions	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
DTH2_k127_1290287_2	1131269.AQVV01000115_gene2303	1.763e-09	64.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
DTH2_k127_1295114_2	1121430.JMLG01000006_gene1691	7.59e-89	300.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,260EM@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
DTH2_k127_1295114_1	309799.DICTH_1686	5.542e-100	342.0	COG0469@1|root,COG0469@2|Bacteria	2|Bacteria	G	pyruvate kinase activity	pyk	GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009986,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0022607,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065	2.7.1.40,2.7.7.4	ko:K00873,ko:K00958	ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050,M00176,M00596	R00200,R00430,R00529,R01138,R01858,R02320,R04929	RC00002,RC00015,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iECO103_1326.ECO103_1819,iPC815.YPO2393	PEP-utilizers,PK,PK_C
DTH2_k127_1295114_0	575540.Isop_0266	9.112e-185	590.0	COG0606@1|root,COG0606@2|Bacteria,2IWTT@203682|Planctomycetes	203682|Planctomycetes	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
DTH2_k127_1295114_3	1123399.AQVE01000001_gene684	1.243e-07	62.0	COG3291@1|root,COG5295@1|root,COG3291@2|Bacteria,COG5295@2|Bacteria,1RGWM@1224|Proteobacteria,1SKIX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	UW	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_3
DTH2_k127_1301652_0	269799.Gmet_0888	1.588e-44	169.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2WJZR@28221|Deltaproteobacteria,43TIN@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
DTH2_k127_1301652_1	1206744.BAGL01000127_gene7192	1.774e-34	141.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4FUWD@85025|Nocardiaceae	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DTH2_k127_1332173_2	742765.HMPREF9457_00340	9.291e-33	128.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,27VPB@189330|Dorea	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
DTH2_k127_1332173_0	1121346.KB899808_gene3528	2.507e-208	669.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,4H9Z3@91061|Bacilli,26RHB@186822|Paenibacillaceae	91061|Bacilli	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
DTH2_k127_1332173_1	575540.Isop_3482	2.966e-107	364.0	COG2204@1|root,COG2204@2|Bacteria,2IWYY@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
DTH2_k127_1334698_4	1485545.JQLW01000008_gene1984	4.531e-16	87.0	COG0615@1|root,COG0615@2|Bacteria,1N9T6@1224|Proteobacteria	1224|Proteobacteria	IM	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
DTH2_k127_1334698_3	1007096.BAGW01000010_gene2243	4.476e-17	92.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,2N763@216572|Oscillospiraceae	186801|Clostridia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH2_k127_1334698_2	596152.DesU5LDRAFT_0079	1.362e-44	181.0	COG1032@1|root,COG1032@2|Bacteria,1RECP@1224|Proteobacteria,42ZSY@68525|delta/epsilon subdivisions,2WV3E@28221|Deltaproteobacteria,2M7UT@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
DTH2_k127_1334698_1	1128398.Curi_c00460	2.034e-56	216.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
DTH2_k127_1334698_0	455436.DS989810_gene542	3.638e-107	371.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,1RQCS@1236|Gammaproteobacteria,46997@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
DTH2_k127_1335829_1	160799.PBOR_04680	3.159e-49	192.0	COG5492@1|root,COG5492@2|Bacteria,1UIHA@1239|Firmicutes,4ISHJ@91061|Bacilli,26U12@186822|Paenibacillaceae	91061|Bacilli	N	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2
DTH2_k127_1335829_2	642492.Clole_3290	2.689e-21	104.0	2CJFT@1|root,33S4U@2|Bacteria,1VT8S@1239|Firmicutes,24BNP@186801|Clostridia	186801|Clostridia	S	Streptomycin adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Adenyl_transf
DTH2_k127_1335829_0	697281.Mahau_2681	2.98e-114	395.0	COG5492@1|root,COG5492@2|Bacteria,1UIHA@1239|Firmicutes,25GPW@186801|Clostridia,42IXE@68295|Thermoanaerobacterales	1239|Firmicutes	N	Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CBM_6
DTH2_k127_1335829_3	658086.HMPREF0994_03836	7.425e-10	68.0	COG0407@1|root,COG0407@2|Bacteria,1VJHK@1239|Firmicutes,24TV3@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_137739_1	1120973.AQXL01000134_gene1576	6.058e-97	324.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,4HAIQ@91061|Bacilli,2784W@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
DTH2_k127_137739_7	1514668.JOOA01000002_gene1164	1.879e-31	126.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,3WJM9@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
DTH2_k127_137739_6	237368.SCABRO_02670	6.799e-35	146.0	COG0682@1|root,COG0682@2|Bacteria,2IZQ2@203682|Planctomycetes	203682|Planctomycetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT,PDZ
DTH2_k127_137739_0	373903.Hore_19530	5.861e-188	597.0	COG2115@1|root,COG2115@2|Bacteria,1TQW2@1239|Firmicutes,24869@186801|Clostridia	186801|Clostridia	G	Belongs to the xylose isomerase family	xylA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08960	AP_endonuc_2
DTH2_k127_137739_3	595460.RRSWK_02091	3.819e-60	222.0	COG1609@1|root,COG4977@1|root,COG1609@2|Bacteria,COG4977@2|Bacteria,2IXTX@203682|Planctomycetes	203682|Planctomycetes	K	Xylose operon regulatory protein	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,Peripla_BP_3
DTH2_k127_137739_4	338963.Pcar_2463	9.828e-48	178.0	COG0655@1|root,COG0655@2|Bacteria,1RKK7@1224|Proteobacteria,42T1X@68525|delta/epsilon subdivisions,2WPCQ@28221|Deltaproteobacteria,43V03@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DTH2_k127_137739_2	56780.SYN_02176	1.229e-76	273.0	COG1032@1|root,COG1032@2|Bacteria,1R4XI@1224|Proteobacteria,42NPM@68525|delta/epsilon subdivisions,2WJK2@28221|Deltaproteobacteria,2MQ6Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
DTH2_k127_137739_5	406817.XNC1_4334	6.624e-35	136.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
DTH2_k127_1379154_5	1142394.PSMK_15560	1.62e-36	149.0	COG1277@1|root,COG1277@2|Bacteria,2IYX5@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
DTH2_k127_1379154_4	289376.THEYE_A1043	5.135e-44	164.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argH	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K00619,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0946	ASL_C2,Acetyltransf_1,Lyase_1
DTH2_k127_1379154_0	237368.SCABRO_00123	1.796e-219	699.0	COG3225@1|root,COG3225@2|Bacteria,2IXSG@203682|Planctomycetes	203682|Planctomycetes	N	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_5,ABC_transp_aux
DTH2_k127_1379154_2	237368.SCABRO_00124	7.176e-100	331.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5,ABC_transp_aux
DTH2_k127_1379154_1	237368.SCABRO_00125	1.376e-114	374.0	COG1131@1|root,COG1131@2|Bacteria,2IXQV@203682|Planctomycetes	203682|Planctomycetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH2_k127_142361_10	794903.OPIT5_12135	4.867e-66	244.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,F5_F8_type_C,Pectate_lyase_3
DTH2_k127_142361_0	1232410.KI421421_gene3404	3.371e-155	509.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,43SD2@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,sCache_like
DTH2_k127_142361_7	880072.Desac_2636	2.084e-90	302.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DTH2_k127_142361_2	530564.Psta_4235	2.273e-129	422.0	COG0436@1|root,COG0436@2|Bacteria,2IX5E@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH2_k127_142361_14	344747.PM8797T_08364	3.279e-09	61.0	2DRVG@1|root,33D8Q@2|Bacteria,2J19Z@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_142361_15	1142394.PSMK_17300	9.053e-09	58.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
DTH2_k127_142361_5	1142394.PSMK_17290	5.439e-97	327.0	COG0416@1|root,COG0416@2|Bacteria,2IWUY@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
DTH2_k127_142361_3	404380.Gbem_3108	7.558e-108	359.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,43S1E@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH-2	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
DTH2_k127_142361_6	314230.DSM3645_16620	2.069e-90	307.0	COG0331@1|root,COG0331@2|Bacteria,2IXX2@203682|Planctomycetes	203682|Planctomycetes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
DTH2_k127_142361_9	1121296.JONJ01000001_gene1849	1.869e-69	243.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,21YUI@1506553|Lachnoclostridium	186801|Clostridia	IQ	COG COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DTH2_k127_142361_12	886293.Sinac_1364	1.038e-25	108.0	COG0236@1|root,COG0236@2|Bacteria,2J0V5@203682|Planctomycetes	203682|Planctomycetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
DTH2_k127_142361_1	1449126.JQKL01000022_gene140	2.257e-144	468.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,267N3@186813|unclassified Clostridiales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
DTH2_k127_142361_11	1149133.ppKF707_3296	2.777e-61	221.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1YF8Z@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iSBO_1134.SBO_0282,ic_1306.c0493	F420_oxidored,P5CR_dimer
DTH2_k127_142361_8	521674.Plim_0381	1.627e-76	277.0	COG0568@1|root,COG0568@2|Bacteria,2IY72@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
DTH2_k127_142361_13	525897.Dbac_1487	4.414e-23	105.0	2C6CX@1|root,2ZT6M@2|Bacteria,1PAC6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_142361_4	595460.RRSWK_05050	3.195e-98	337.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
DTH2_k127_1437952_2	888832.HMPREF9420_0914	3.462e-13	72.0	COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,2FPCB@200643|Bacteroidia	976|Bacteroidetes	C	iron-sulfur cluster-binding protein	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
DTH2_k127_1437952_0	555088.DealDRAFT_2869	9.733e-177	558.0	COG1830@1|root,COG1830@2|Bacteria,1TR60@1239|Firmicutes	1239|Firmicutes	G	DeoC/LacD family aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DeoC
DTH2_k127_1437952_1	1121344.JHZO01000004_gene1662	5.555e-34	138.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,25BXB@186801|Clostridia,3WS9U@541000|Ruminococcaceae	186801|Clostridia	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
DTH2_k127_1442917_2	1232437.KL662014_gene1293	8.952e-103	354.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MINP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HBM,MCPsignal
DTH2_k127_1442917_1	29581.BW37_00264	8.313e-134	437.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,474BV@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DTH2_k127_1442917_9	756272.Plabr_1022	3.644e-19	89.0	COG1551@1|root,COG1551@2|Bacteria	2|Bacteria	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
DTH2_k127_1442917_4	720554.Clocl_0784	7.226e-59	214.0	COG0145@1|root,COG0145@2|Bacteria,1V3GN@1239|Firmicutes,25DNJ@186801|Clostridia,3WPEF@541000|Ruminococcaceae	186801|Clostridia	EQ	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
DTH2_k127_1442917_7	926569.ANT_16820	7.392e-42	167.0	COG1408@1|root,COG1408@2|Bacteria,2G6VC@200795|Chloroflexi	200795|Chloroflexi	S	PFAM metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
DTH2_k127_1442917_6	702450.CUW_1655	3.977e-50	184.0	COG1971@1|root,COG1971@2|Bacteria,1V4QK@1239|Firmicutes,3VQI6@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
DTH2_k127_1442917_3	1268237.G114_09189	8.842e-85	292.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1Y40H@135624|Aeromonadales	1236|Gammaproteobacteria	P	COG0530 Ca2 Na antiporter	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
DTH2_k127_1442917_8	237368.SCABRO_02414	1.043e-40	158.0	COG2928@1|root,COG2928@2|Bacteria,2IZGR@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
DTH2_k127_1442917_11	595460.RRSWK_01971	4.239e-06	55.0	28Z0A@1|root,2ZKSY@2|Bacteria,2J4HE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1442917_0	1254432.SCE1572_20560	1.807e-163	525.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria	1224|Proteobacteria	G	TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
DTH2_k127_1442917_5	1254432.SCE1572_20555	1.112e-50	184.0	COG3090@1|root,COG3090@2|Bacteria,1PJMJ@1224|Proteobacteria,42XS6@68525|delta/epsilon subdivisions,2WSJP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
DTH2_k127_1442917_10	1254432.SCE1572_20550	3.635e-16	79.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,42M9R@68525|delta/epsilon subdivisions,2WKQM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
DTH2_k127_1443967_0	1121440.AUMA01000008_gene877	7.121e-172	544.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2M8PC@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
DTH2_k127_1443967_2	886293.Sinac_3598	4.28e-60	218.0	2CB5F@1|root,2ZCDM@2|Bacteria,2IXTM@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1443967_1	247490.KSU1_C1001	3.758e-64	225.0	COG0104@1|root,COG0104@2|Bacteria,2IWZH@203682|Planctomycetes	203682|Planctomycetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DTH2_k127_1478559_4	589865.DaAHT2_0192	2.655e-09	60.0	2DR7G@1|root,33AJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1478559_2	1123508.JH636441_gene3274	5.022e-69	244.0	COG0063@1|root,COG0063@2|Bacteria,2IYWH@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase
DTH2_k127_1478559_0	1122919.KB905560_gene1480	1.199e-153	490.0	COG3458@1|root,COG3458@2|Bacteria,1TS02@1239|Firmicutes,4HDID@91061|Bacilli,26QEJ@186822|Paenibacillaceae	91061|Bacilli	Q	Acetyl esterase	cah	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
DTH2_k127_1478559_1	1209989.TepiRe1_1457	5.093e-83	291.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,42ER8@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DTH2_k127_1478559_3	886293.Sinac_7067	2.429e-30	126.0	COG0824@1|root,COG0824@2|Bacteria,2J0BH@203682|Planctomycetes	203682|Planctomycetes	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
DTH2_k127_1478559_5	1242864.D187_000064	6.95e-06	52.0	COG2866@1|root,COG2866@2|Bacteria,1R6VU@1224|Proteobacteria	1224|Proteobacteria	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
DTH2_k127_1494573_2	1408254.T458_06775	7.735e-77	269.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,26QN5@186822|Paenibacillaceae	91061|Bacilli	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DTH2_k127_1494573_0	1480694.DC28_05205	4.883e-124	415.0	COG0082@1|root,COG0082@2|Bacteria,2J5CX@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
DTH2_k127_1494573_1	1121101.HMPREF1532_04073	9.449e-122	406.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	ko:K03931	-	-	-	-	ko00000	-	GH63	-	Glyco_hydro_63,Trehalase
DTH2_k127_1494573_3	580327.Tthe_1892	8.002e-21	93.0	COG0863@1|root,COG0863@2|Bacteria,1TPR7@1239|Firmicutes,24A3P@186801|Clostridia,42ESE@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
DTH2_k127_1511793_2	237368.SCABRO_02566	7.825e-71	248.0	COG0535@1|root,COG0535@2|Bacteria,2IZE3@203682|Planctomycetes	203682|Planctomycetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
DTH2_k127_1511793_1	247490.KSU1_C1592	1.288e-74	267.0	COG0373@1|root,COG0373@2|Bacteria,2IXE9@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
DTH2_k127_1511793_7	243231.GSU3283	3.334e-07	61.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43TXA@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
DTH2_k127_1511793_5	1379281.AVAG01000047_gene354	4.263e-37	146.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,42R2R@68525|delta/epsilon subdivisions,2WMSJ@28221|Deltaproteobacteria,2MBJW@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_AsnC-type
DTH2_k127_1511793_0	340099.Teth39_1889	1.144e-130	424.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
DTH2_k127_1511793_6	305700.B447_20146	3.311e-13	79.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VPSB@28216|Betaproteobacteria,2KYVS@206389|Rhodocyclales	206389|Rhodocyclales	M	COG1596 Periplasmic protein involved in polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
DTH2_k127_1511793_4	913848.AELK01000061_gene2256	6.48e-38	151.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,4HBHA@91061|Bacilli,3F3JG@33958|Lactobacillaceae	91061|Bacilli	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
DTH2_k127_1511793_8	1210884.HG799466_gene12823	0.0003791	49.0	2DEAU@1|root,2ZM6U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1511793_3	314230.DSM3645_18836	1.825e-45	167.0	COG0780@1|root,COG0780@2|Bacteria,2J07W@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
DTH2_k127_1526683_6	46234.ANA_C11553	2.013e-22	98.0	COG1073@1|root,COG1073@2|Bacteria,1G1YP@1117|Cyanobacteria,1HM0E@1161|Nostocales	1117|Cyanobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
DTH2_k127_1526683_9	28258.KP05_12910	5.378e-09	68.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1XHUC@135619|Oceanospirillales	135619|Oceanospirillales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
DTH2_k127_1526683_2	595460.RRSWK_06558	1.026e-85	295.0	COG2755@1|root,COG2755@2|Bacteria,2IYGD@203682|Planctomycetes	203682|Planctomycetes	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DTH2_k127_1526683_1	886293.Sinac_7540	1.73e-195	620.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2IX43@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
DTH2_k127_1526683_5	243090.RB5346	4.939e-46	170.0	COG1943@1|root,COG1943@2|Bacteria,2J0GJ@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
DTH2_k127_1526683_0	530564.Psta_2814	1.846e-222	700.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2IX19@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
DTH2_k127_1526683_7	316067.Geob_1132	2.124e-17	85.0	COG1708@1|root,COG1708@2|Bacteria,1Q4M3@1224|Proteobacteria,433G8@68525|delta/epsilon subdivisions,2WXQC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
DTH2_k127_1526683_8	545694.TREPR_3870	3.396e-14	79.0	COG2250@1|root,COG2250@2|Bacteria,2J9AK@203691|Spirochaetes	203691|Spirochaetes	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
DTH2_k127_1526683_3	1396418.BATQ01000099_gene5567	9.389e-68	246.0	COG1520@1|root,COG1520@2|Bacteria,46U6I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
DTH2_k127_1526683_4	289376.THEYE_A1649	1.513e-51	190.0	COG0289@1|root,COG0289@2|Bacteria,3J0IJ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
DTH2_k127_1534317_0	909663.KI867151_gene3159	2.885e-55	213.0	COG2202@1|root,COG4191@1|root,COG4585@1|root,COG5001@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K21084	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3,dCache_1
DTH2_k127_1534317_1	1304885.AUEY01000045_gene252	1.835e-51	189.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42RQX@68525|delta/epsilon subdivisions,2WNM1@28221|Deltaproteobacteria,2MJTS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DTH2_k127_1542421_6	931626.Awo_c02290	4.086e-11	69.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,25VU6@186806|Eubacteriaceae	186801|Clostridia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
DTH2_k127_1542421_3	243233.MCA1284	1.456e-83	281.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1XF1P@135618|Methylococcales	135618|Methylococcales	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
DTH2_k127_1542421_0	401526.TcarDRAFT_2658	8.774e-138	443.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H1YA@909932|Negativicutes	909932|Negativicutes	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DTH2_k127_1542421_2	886293.Sinac_0986	2.133e-106	355.0	COG0016@1|root,COG0016@2|Bacteria,2IXSW@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
DTH2_k127_1542421_5	428125.CLOLEP_03301	1.8e-32	129.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3WIYY@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
DTH2_k127_1542421_7	1499684.CCNP01000021_gene2814	1.245e-08	58.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,36MNG@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
DTH2_k127_1542421_4	1122135.KB893134_gene3592	2.737e-47	177.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
DTH2_k127_1542421_1	477974.Daud_1384	1.128e-136	443.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,25ZYB@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
DTH2_k127_1599538_4	1122236.KB905141_gene1761	2.692e-12	75.0	COG0438@1|root,COG0515@1|root,COG0438@2|Bacteria,COG0515@2|Bacteria,1NE3V@1224|Proteobacteria,2VJET@28216|Betaproteobacteria,2KMF4@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Glycosyltransferase Family 4	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1,Kdo
DTH2_k127_1599538_2	247634.GPB2148_899	1.76e-59	218.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1J4K0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0859 ADP-heptose LPS heptosyltransferase	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
DTH2_k127_1599538_3	1150600.ADIARSV_1233	2.861e-45	177.0	COG0241@1|root,COG0241@2|Bacteria,4NPBC@976|Bacteroidetes,1ISEE@117747|Sphingobacteriia	976|Bacteroidetes	E	D,D-heptose 1,7-bisphosphate phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like,NTP_transferase
DTH2_k127_1599538_0	1210884.HG799465_gene11565	1.418e-128	428.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2IY6V@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
DTH2_k127_1599538_1	344747.PM8797T_06767	4.036e-67	239.0	COG1663@1|root,COG1663@2|Bacteria,2IXYX@203682|Planctomycetes	203682|Planctomycetes	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
DTH2_k127_1603139_4	523845.AQXV01000053_gene723	7.782e-19	89.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y02Z@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
DTH2_k127_1603139_1	525146.Ddes_2207	6.344e-109	370.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2M9KC@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
DTH2_k127_1603139_2	1190603.AJYD01000081_gene290	1.622e-77	270.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XSM4@135623|Vibrionales	135623|Vibrionales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
DTH2_k127_1603139_3	1123508.JH636443_gene4517	2.334e-34	136.0	COG0234@1|root,COG0234@2|Bacteria,2J027@203682|Planctomycetes	203682|Planctomycetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
DTH2_k127_1603139_0	481448.Minf_2176	1.372e-140	454.0	COG0459@1|root,COG0459@2|Bacteria,46S9U@74201|Verrucomicrobia,37G43@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
DTH2_k127_1631217_1	1094980.Mpsy_2980	7.06e-187	622.0	COG0745@1|root,COG0784@1|root,COG2203@1|root,arCOG02348@1|root,arCOG02352@1|root,arCOG02360@1|root,arCOG02376@1|root,arCOG04001@1|root,arCOG02348@2157|Archaea,arCOG02352@2157|Archaea,arCOG02357@2157|Archaea,arCOG02360@2157|Archaea,arCOG02376@2157|Archaea,arCOG02591@2157|Archaea,arCOG02595@2157|Archaea,arCOG04001@2157|Archaea,2Y82D@28890|Euryarchaeota,2NBNN@224756|Methanomicrobia	2157|Archaea	T	Histidine Phosphotransfer domain	-	-	2.7.7.65	ko:K02488,ko:K11443	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	BAT,GAF,GAF_2,GAF_3,HATPase_c,HTH_10,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
DTH2_k127_1631217_5	1322246.BN4_20153	6.78e-69	250.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PU9@68525|delta/epsilon subdivisions,2WU8U@28221|Deltaproteobacteria,2M8K7@213115|Desulfovibrionales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
DTH2_k127_1631217_2	314285.KT71_13669	1.228e-138	462.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	DUF3347,HlyD_D23,HlyD_D4,YtkA
DTH2_k127_1631217_9	335543.Sfum_1432	9.245e-13	81.0	COG3350@1|root,COG3350@2|Bacteria,1NE2T@1224|Proteobacteria,42VZQ@68525|delta/epsilon subdivisions,2WSDU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
DTH2_k127_1631217_7	525897.Dbac_2312	6.116e-14	76.0	COG3350@1|root,COG3350@2|Bacteria,1NE2T@1224|Proteobacteria,42VZQ@68525|delta/epsilon subdivisions,2WSDU@28221|Deltaproteobacteria,2MD4Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
DTH2_k127_1631217_0	641491.DND132_1936	0.0	1355.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,43EBY@68525|delta/epsilon subdivisions,2X7W0@28221|Deltaproteobacteria,2MHDJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
DTH2_k127_1631217_6	344747.PM8797T_01504	5.072e-20	95.0	COG2001@1|root,COG2001@2|Bacteria	2|Bacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
DTH2_k127_1631217_4	986075.CathTA2_2297	3.61e-74	261.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H9U2@91061|Bacilli	91061|Bacilli	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
DTH2_k127_1631217_11	1408323.JQKK01000015_gene2528	1.22e-06	61.0	COG1652@1|root,COG2733@1|root,COG1652@2|Bacteria,COG2733@2|Bacteria,1UKI3@1239|Firmicutes,25HHS@186801|Clostridia,27PEB@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
DTH2_k127_1631217_3	521674.Plim_1789	1.133e-100	349.0	COG0768@1|root,COG0768@2|Bacteria,2IXEK@203682|Planctomycetes	203682|Planctomycetes	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
DTH2_k127_1631217_8	575540.Isop_0346	2.81e-13	83.0	COG0795@1|root,COG0795@2|Bacteria,2IZJF@203682|Planctomycetes	203682|Planctomycetes	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
DTH2_k127_1631217_10	1307761.L21SP2_1806	4.548e-07	59.0	COG0795@1|root,COG0795@2|Bacteria,2J64B@203691|Spirochaetes	203691|Spirochaetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
DTH2_k127_1650560_0	485913.Krac_3872	6.309e-209	670.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
DTH2_k127_1650560_5	1235792.C808_04908	5.491e-41	165.0	COG1397@1|root,COG1397@2|Bacteria,1VJGR@1239|Firmicutes,24SQ2@186801|Clostridia	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
DTH2_k127_1650560_1	1042377.AFPJ01000036_gene1215	1.758e-116	392.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,46CM3@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
DTH2_k127_1650560_4	521045.Kole_1275	3.671e-57	208.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K03589,ko:K07491	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	Y1_Tnp
DTH2_k127_1650560_2	1191523.MROS_2095	6.19e-102	340.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
DTH2_k127_1650560_3	706587.Desti_0312	1.39e-60	218.0	COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria,2MRRP@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1657170_1	158190.SpiGrapes_2806	3.324e-31	132.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	2|Bacteria	O	HflC and HflK could regulate a protease	hflC2	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
DTH2_k127_1657170_0	1142394.PSMK_15610	1.704e-65	248.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DTH2_k127_1669474_1	243090.RB8731	8.262e-128	415.0	COG0524@1|root,COG0524@2|Bacteria,2IY5G@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
DTH2_k127_1669474_0	278963.ATWD01000002_gene485	2.052e-194	612.0	COG3875@1|root,COG3875@2|Bacteria,3Y3WS@57723|Acidobacteria,2JHW7@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DTH2_k127_1712133_0	1379698.RBG1_1C00001G0460	1.348e-299	951.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
DTH2_k127_1721796_2	655815.ZPR_2727	5.791e-23	99.0	COG0012@1|root,COG0012@2|Bacteria,4NF7N@976|Bacteroidetes,1HWMK@117743|Flavobacteriia	976|Bacteroidetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
DTH2_k127_1721796_0	1304880.JAGB01000002_gene1618	4.54e-133	439.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
DTH2_k127_1721796_1	292563.Cyast_2727	1.986e-64	233.0	COG0210@1|root,COG0210@2|Bacteria,1G17G@1117|Cyanobacteria	1117|Cyanobacteria	L	DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
DTH2_k127_1744635_4	697281.Mahau_0471	4.224e-54	202.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24J5K@186801|Clostridia,42I4V@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_1744635_1	1123274.KB899413_gene778	1.94e-113	372.0	COG0543@1|root,COG0543@2|Bacteria,2J5SH@203691|Spirochaetes	203691|Spirochaetes	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
DTH2_k127_1744635_0	573413.Spirs_1641	2.101e-207	655.0	COG0493@1|root,COG0493@2|Bacteria,2J5FP@203691|Spirochaetes	203691|Spirochaetes	C	glutamate synthase (NADPH), homotetrameric	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
DTH2_k127_1744635_7	1048983.EL17_16370	4.121e-08	66.0	COG2197@1|root,COG2197@2|Bacteria,4NMX5@976|Bacteroidetes,47PYR@768503|Cytophagia	976|Bacteroidetes	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DTH2_k127_1744635_6	641491.DND132_2898	1.199e-34	151.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
DTH2_k127_1744635_5	1236514.BAKL01000144_gene5702	1.372e-52	203.0	COG0386@1|root,COG0386@2|Bacteria,4NM6G@976|Bacteroidetes,2FQY1@200643|Bacteroidia,4AQ9D@815|Bacteroidaceae	976|Bacteroidetes	O	Belongs to the glutathione peroxidase family	bsaA	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
DTH2_k127_1744635_3	1158294.JOMI01000004_gene3543	6.506e-88	306.0	COG3386@1|root,COG3386@2|Bacteria,4NF4A@976|Bacteroidetes,2FSDK@200643|Bacteroidia	976|Bacteroidetes	G	SMP-30 Gluconolaconase LRE-like	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pectate_lyase_3,SGL
DTH2_k127_1744635_9	1048339.KB913029_gene892	0.0004608	48.0	COG0745@1|root,COG0745@2|Bacteria,2IM7B@201174|Actinobacteria,4ET70@85013|Frankiales	201174|Actinobacteria	T	Response regulator receiver	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
DTH2_k127_1744635_2	247490.KSU1_D0838	9.52e-107	357.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03250	HMGL-like,dCache_1
DTH2_k127_178210_3	909663.KI867150_gene299	1.064e-10	64.0	COG1918@1|root,COG1918@2|Bacteria,1Q2C4@1224|Proteobacteria,437YI@68525|delta/epsilon subdivisions,2X38E@28221|Deltaproteobacteria,2MSDZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
DTH2_k127_178210_2	644282.Deba_1956	7.869e-36	141.0	COG1321@1|root,COG1321@2|Bacteria,1RHIK@1224|Proteobacteria,42SAD@68525|delta/epsilon subdivisions,2WPIC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Iron (Metal) dependent repressor, DtxR family	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
DTH2_k127_178210_0	1519464.HY22_02080	4.357e-223	707.0	COG0449@1|root,COG0449@2|Bacteria,1FDCR@1090|Chlorobi	1090|Chlorobi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DTH2_k127_178210_1	880073.Calab_0984	2.725e-72	261.0	COG0265@1|root,COG0265@2|Bacteria,2NQK9@2323|unclassified Bacteria	2|Bacteria	O	Trypsin	degQ	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
DTH2_k127_1792508_6	237368.SCABRO_00353	4.065e-37	143.0	COG0620@1|root,COG0620@2|Bacteria,2J2EU@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1792508_3	401526.TcarDRAFT_1748	9.425e-72	251.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,4H4QV@909932|Negativicutes	909932|Negativicutes	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
DTH2_k127_1792508_4	1125863.JAFN01000001_gene2547	6.23e-59	215.0	COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
DTH2_k127_1792508_1	909663.KI867150_gene97	1.658e-209	669.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MQ8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
DTH2_k127_1792508_0	555779.Dthio_PD3239	3.834e-299	955.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
DTH2_k127_1792508_2	1123288.SOV_1c07660	4.171e-81	306.0	COG2069@1|root,COG2069@2|Bacteria,1TSSY@1239|Firmicutes,4H6FX@909932|Negativicutes	909932|Negativicutes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD
DTH2_k127_1792508_5	247490.KSU1_D0224	1.641e-41	157.0	COG1456@1|root,COG1456@2|Bacteria,2J2CN@203682|Planctomycetes	203682|Planctomycetes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,FeS
DTH2_k127_1793101_1	264732.Moth_2477	2.384e-79	277.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,42FGS@68295|Thermoanaerobacterales	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	engD	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
DTH2_k127_1793101_5	1250006.JHZZ01000001_gene1150	1.388e-23	105.0	2AR54@1|root,31GER@2|Bacteria,4NSCR@976|Bacteroidetes,1I3RB@117743|Flavobacteriia	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
DTH2_k127_1793101_2	1125863.JAFN01000001_gene1785	3.598e-61	216.0	COG1838@1|root,COG1838@2|Bacteria,1RCSV@1224|Proteobacteria,42NRW@68525|delta/epsilon subdivisions,2X5RX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
DTH2_k127_1793101_3	498761.HM1_1963	9.012e-39	153.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia	186801|Clostridia	H	Siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
DTH2_k127_1793101_0	404380.Gbem_0736	1.088e-102	346.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WJQV@28221|Deltaproteobacteria,43S19@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
DTH2_k127_1793101_4	1105031.HMPREF1141_2329	1.413e-26	113.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,36DKE@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
DTH2_k127_179397_3	1379698.RBG1_1C00001G1364	2.701e-58	221.0	COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K02005,ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
DTH2_k127_179397_1	1487921.DP68_16855	1.037e-84	287.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH2_k127_179397_2	886293.Sinac_4399	1.001e-67	246.0	COG0577@1|root,COG0577@2|Bacteria,2IY2P@203682|Planctomycetes	203682|Planctomycetes	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
DTH2_k127_179397_0	265072.Mfla_2221	4.978e-92	323.0	COG1538@1|root,COG1538@2|Bacteria,1NEHN@1224|Proteobacteria,2VYWE@28216|Betaproteobacteria,2KKVJ@206350|Nitrosomonadales	206350|Nitrosomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
DTH2_k127_179397_4	313612.L8106_07274	3.017e-16	88.0	COG0823@1|root,COG0823@2|Bacteria,1GBDE@1117|Cyanobacteria	1117|Cyanobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_179397_5	546271.Selsp_1864	3.242e-06	53.0	COG2165@1|root,COG2165@2|Bacteria,1VK8F@1239|Firmicutes,4H621@909932|Negativicutes	909932|Negativicutes	U	General secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
DTH2_k127_1821790_1	1123393.KB891316_gene1685	3.338e-87	293.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,1KRE8@119069|Hydrogenophilales	119069|Hydrogenophilales	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
DTH2_k127_1821790_2	243233.MCA0196	1.216e-44	166.0	COG1371@1|root,COG1371@2|Bacteria,1RJU0@1224|Proteobacteria,1S8F6@1236|Gammaproteobacteria,1XFH0@135618|Methylococcales	135618|Methylococcales	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
DTH2_k127_1821790_0	56780.SYN_00416	1.674e-87	291.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MR55@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
DTH2_k127_185245_1	370438.PTH_1619	2.796e-72	253.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,26081@186807|Peptococcaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
DTH2_k127_185245_0	1142394.PSMK_26660	5.496e-219	692.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,2IXPK@203682|Planctomycetes	203682|Planctomycetes	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
DTH2_k127_187274_0	9601.ENSPPYP00000003133	5.157e-06	58.0	28N19@1|root,2QUK7@2759|Eukaryota,38HHN@33154|Opisthokonta,3BCH4@33208|Metazoa,3CRT4@33213|Bilateria,47ZJY@7711|Chordata,48WI3@7742|Vertebrata,3J4I2@40674|Mammalia,35DQV@314146|Euarchontoglires,4MATQ@9443|Primates,4N5I2@9604|Hominidae	33208|Metazoa	W	Lipoxygenase homology 2 (beta barrel) domain	PNLIPRP2	GO:0003674,GO:0003824,GO:0004620,GO:0004806,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0006952,GO:0006968,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009605,GO:0009719,GO:0009725,GO:0009791,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0012505,GO:0012506,GO:0014070,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0019374,GO:0019376,GO:0019377,GO:0019637,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031667,GO:0031960,GO:0031982,GO:0032094,GO:0032501,GO:0032502,GO:0033993,GO:0042221,GO:0042588,GO:0042589,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043434,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044258,GO:0044421,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0046434,GO:0046466,GO:0046872,GO:0047372,GO:0047714,GO:0048545,GO:0048856,GO:0050896,GO:0051384,GO:0052689,GO:0071704,GO:0097708,GO:0098588,GO:0098805,GO:0099503,GO:1901135,GO:1901136,GO:1901575,GO:1901652,GO:1901698,GO:1901700,GO:1903509	3.1.1.3	ko:K14073,ko:K14074,ko:K14075	ko00561,ko01100,ko04972,ko04975,ko04977,map00561,map01100,map04972,map04975,map04977	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase,PLAT
DTH2_k127_1893888_1	63737.Npun_R0752	3.541e-95	321.0	COG0079@1|root,COG0079@2|Bacteria,1FZV3@1117|Cyanobacteria,1HK2F@1161|Nostocales	1117|Cyanobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iJN678.hisC	Aminotran_1_2
DTH2_k127_1893888_2	178901.AmDm5_0916	8.386e-68	235.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,2JPDI@204441|Rhodospirillales	204441|Rhodospirillales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
DTH2_k127_1893888_3	75379.Tint_1688	1.047e-52	191.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,1KKK3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
DTH2_k127_1893888_0	247490.KSU1_D0522	2.084e-185	591.0	COG0215@1|root,COG0215@2|Bacteria,2IX9C@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
DTH2_k127_1893888_5	886293.Sinac_5253	2.928e-39	151.0	COG0817@1|root,COG0817@2|Bacteria,2IZJS@203682|Planctomycetes	203682|Planctomycetes	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
DTH2_k127_1893888_4	247490.KSU1_C1283	7.04e-44	164.0	COG0614@1|root,COG0614@2|Bacteria,2J0J0@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
DTH2_k127_1893888_6	344747.PM8797T_03890	2.09e-31	130.0	COG0632@1|root,COG0632@2|Bacteria,2IZ2E@203682|Planctomycetes	203682|Planctomycetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
DTH2_k127_1905835_0	247490.KSU1_C1357	5.59e-113	379.0	COG0281@1|root,COG0281@2|Bacteria,2J0KC@203682|Planctomycetes	203682|Planctomycetes	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
DTH2_k127_1905835_2	203119.Cthe_0732	8.991e-72	259.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,3WG94@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
DTH2_k127_1905835_1	1399147.P618_200404	4.267e-99	329.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2TT3J@28211|Alphaproteobacteria,47F3E@766|Rickettsiales	766|Rickettsiales	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
DTH2_k127_192041_2	745310.G432_07475	1.943e-13	84.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,2K0ZQ@204457|Sphingomonadales	204457|Sphingomonadales	U	Belongs to the GSP D family	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
DTH2_k127_192041_1	269799.Gmet_0975	1.804e-17	97.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,43UJ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
DTH2_k127_192041_0	1123242.JH636435_gene2712	3.786e-113	380.0	COG0621@1|root,COG0621@2|Bacteria,2IWTE@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
DTH2_k127_192041_3	497964.CfE428DRAFT_4431	3.227e-12	74.0	COG1361@1|root,COG1520@1|root,COG1572@1|root,COG3227@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1572@2|Bacteria,COG3227@2|Bacteria	2|Bacteria	E	Zinc metalloprotease (Elastase)	-	-	-	ko:K20274	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	CHU_C,FTP,PQQ_2,Peptidase_M36
DTH2_k127_1950886_8	1379270.AUXF01000002_gene1693	3.104e-13	71.0	COG0835@1|root,COG0835@2|Bacteria,1ZTR5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
DTH2_k127_1950886_6	1168289.AJKI01000040_gene3174	1.321e-30	140.0	2DYE6@1|root,349BE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1950886_7	1047013.AQSP01000130_gene1868	4.458e-28	116.0	COG0407@1|root,COG0407@2|Bacteria,2NQRU@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_1950886_9	1499967.BAYZ01000062_gene6038	0.0002152	45.0	COG0407@1|root,COG0407@2|Bacteria,2NQRU@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_1950886_2	717605.Theco_2601	2.645e-97	332.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,4HC0B@91061|Bacilli,26U8T@186822|Paenibacillaceae	91061|Bacilli	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DTH2_k127_1950886_4	1123242.JH636435_gene2071	8.897e-60	222.0	COG1609@1|root,COG1609@2|Bacteria,2J18R@203682|Planctomycetes	203682|Planctomycetes	K	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
DTH2_k127_1950886_3	794903.OPIT5_25795	3.941e-63	235.0	COG2211@1|root,COG2211@2|Bacteria,46Y3F@74201|Verrucomicrobia,3K8VH@414999|Opitutae	414999|Opitutae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
DTH2_k127_1950886_1	545695.TREAZ_2757	1.184e-114	378.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH2_k127_1950886_0	697281.Mahau_2024	2.848e-141	471.0	COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia,42FZN@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.165,3.2.1.25	ko:K01192,ko:K15855	ko00511,ko00520,ko01100,ko04142,map00511,map00520,map01100,map04142	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DTH2_k127_1958450_0	794903.OPIT5_12060	7.618e-110	374.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DTH2_k127_1961721_0	1047013.AQSP01000144_gene852	2.814e-64	229.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
DTH2_k127_1961721_1	383372.Rcas_1611	1.539e-49	183.0	COG5340@1|root,COG5340@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
DTH2_k127_196243_0	980584.AFPB01000179_gene3452	1.298e-151	492.0	COG0541@1|root,COG0541@2|Bacteria,4NDZ2@976|Bacteroidetes,1HXT4@117743|Flavobacteriia,405TV@61432|unclassified Flavobacteriaceae	976|Bacteroidetes	U	SRP54-type protein, helical bundle domain	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
DTH2_k127_196243_4	794903.OPIT5_15050	1.209e-08	65.0	COG2165@1|root,COG2165@2|Bacteria,46Z9D@74201|Verrucomicrobia,3K9IE@414999|Opitutae	2|Bacteria	U	Protein of unknown function (DUF1559)	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
DTH2_k127_196243_3	1433126.BN938_2732	8.543e-99	352.0	COG1520@1|root,COG1520@2|Bacteria,4P0ZC@976|Bacteroidetes,2FW9F@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
DTH2_k127_196243_2	240016.ABIZ01000001_gene1539	1.168e-111	390.0	COG1520@1|root,COG1520@2|Bacteria,46TV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
DTH2_k127_196243_1	1168034.FH5T_01535	8.573e-115	386.0	COG0493@1|root,COG0493@2|Bacteria,4P2CU@976|Bacteroidetes,2FXPN@200643|Bacteroidia	976|Bacteroidetes	E	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_20
DTH2_k127_1989121_1	502025.Hoch_5884	1.107e-31	139.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2WK2Z@28221|Deltaproteobacteria,2Z0P6@29|Myxococcales	28221|Deltaproteobacteria	K	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
DTH2_k127_1989121_0	882082.SaccyDRAFT_0921	1.653e-195	634.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4DYVA@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
DTH2_k127_1997444_2	1142394.PSMK_20610	3.731e-30	124.0	COG3494@1|root,COG3494@2|Bacteria,2IXGX@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
DTH2_k127_1997444_0	1125863.JAFN01000001_gene3410	5.111e-85	293.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
DTH2_k127_1997444_3	1123508.JH636449_gene7365	8.583e-13	78.0	2EPQ7@1|root,33HAS@2|Bacteria,2J1P9@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1997444_1	411460.RUMTOR_01470	9.133e-48	184.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,3XZQI@572511|Blautia	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
DTH2_k127_200477_0	748449.Halha_2230	2.262e-204	661.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WAH3@53433|Halanaerobiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DTH2_k127_2034070_3	51511.ENSCSAVP00000007210	5.872e-07	55.0	COG1171@1|root,KOG2547@2759|Eukaryota,38DAM@33154|Opisthokonta,3BEY1@33208|Metazoa,3CUEB@33213|Bilateria,48709@7711|Chordata	33208|Metazoa	IM	dihydroceramide glucosyltransferase activity	UGCG	GO:0000139,GO:0002119,GO:0002164,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006677,GO:0006678,GO:0006679,GO:0006687,GO:0006688,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007275,GO:0008120,GO:0008150,GO:0008152,GO:0008194,GO:0008544,GO:0008610,GO:0009056,GO:0009058,GO:0009247,GO:0009719,GO:0009791,GO:0009888,GO:0009987,GO:0010033,GO:0010453,GO:0010470,GO:0010941,GO:0012505,GO:0016020,GO:0016042,GO:0016740,GO:0016757,GO:0016758,GO:0019377,GO:0022603,GO:0023052,GO:0030148,GO:0030149,GO:0031090,GO:0031984,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0034641,GO:0035251,GO:0040008,GO:0040014,GO:0042175,GO:0042221,GO:0042659,GO:0042661,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045995,GO:0046466,GO:0046467,GO:0046476,GO:0046479,GO:0046513,GO:0046527,GO:0048519,GO:0048523,GO:0048638,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051239,GO:0051716,GO:0060341,GO:0060548,GO:0065007,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0071944,GO:0098588,GO:0098791,GO:0098827,GO:1901048,GO:1901135,GO:1901136,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1903509,GO:1903827,GO:1904375,GO:1904508,GO:1905475,GO:1905770,GO:1905902,GO:2000026,GO:2000027,GO:2000380	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
DTH2_k127_2034070_1	754477.Q7C_2250	6.348e-47	187.0	COG0515@1|root,COG0515@2|Bacteria,1R47Q@1224|Proteobacteria,1S6YE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Kdo
DTH2_k127_2034070_5	860228.Ccan_22960	0.0005623	44.0	COG1554@1|root,COG1554@2|Bacteria,4NFG1@976|Bacteroidetes,1HXBI@117743|Flavobacteriia,1ER7R@1016|Capnocytophaga	976|Bacteroidetes	G	hydrolase family 65, central catalytic	-	-	2.4.1.8	ko:K00691	ko00500,ko01100,map00500,map01100	-	R01555	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
DTH2_k127_2034070_2	632292.Calhy_2341	1.682e-13	75.0	COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,24DWR@186801|Clostridia,42JEI@68295|Thermoanaerobacterales	186801|Clostridia	S	HAD-superfamily hydrolase, subfamily IA, variant 3	pgmB	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH2_k127_2034070_0	1304880.JAGB01000002_gene2198	4.703e-68	239.0	COG1874@1|root,COG1874@2|Bacteria,1TT9J@1239|Firmicutes,24CY9@186801|Clostridia	186801|Clostridia	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
DTH2_k127_2053265_2	1232410.KI421421_gene3584	7.296e-47	174.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WP0X@28221|Deltaproteobacteria,43SHS@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
DTH2_k127_2053265_1	404589.Anae109_0363	3.203e-84	289.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2YV2A@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_1278	CBS,SIS
DTH2_k127_2053265_0	886293.Sinac_3259	6.509e-122	402.0	COG1530@1|root,COG1530@2|Bacteria,2IWSS@203682|Planctomycetes	203682|Planctomycetes	J	TIGRFAM ribonuclease, Rne Rng family	-	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
DTH2_k127_2059520_2	391623.TERMP_01702	1.801e-05	51.0	COG2811@1|root,arCOG03363@2157|Archaea,2Y4VV@28890|Euryarchaeota,244QM@183968|Thermococci	183968|Thermococci	C	H subunit	-	-	-	ko:K02107	ko00190,map00190	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
DTH2_k127_2059520_0	886379.AEWI01000034_gene3029	4.115e-18	93.0	COG1102@1|root,COG1102@2|Bacteria,4NU66@976|Bacteroidetes,2G20S@200643|Bacteroidia,3XJCI@558415|Marinilabiliaceae	976|Bacteroidetes	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
DTH2_k127_2070913_0	1121405.dsmv_1742	1.857e-18	86.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2WJ24@28221|Deltaproteobacteria,2MNVV@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
DTH2_k127_2070913_2	545694.TREPR_2122	2.486e-18	88.0	COG1708@1|root,COG1708@2|Bacteria,2JB39@203691|Spirochaetes	203691|Spirochaetes	L	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
DTH2_k127_2070913_1	237368.SCABRO_02126	2.269e-18	89.0	2CF90@1|root,32S1G@2|Bacteria	2|Bacteria	S	Nucleotidyltransferase substrate binding protein like	-	-	-	-	-	-	-	-	-	-	-	-	NTase_sub_bind
DTH2_k127_2083418_0	521674.Plim_2415	3.824e-89	323.0	COG0642@1|root,COG2205@2|Bacteria,2J4YN@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	HATPase_c,HisKA,Response_reg
DTH2_k127_2083418_6	1408439.JHXW01000012_gene889	2.936e-17	91.0	COG1396@1|root,COG1974@1|root,COG1396@2|Bacteria,COG1974@2|Bacteria,3799F@32066|Fusobacteria	32066|Fusobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
DTH2_k127_2083418_1	1121930.AQXG01000003_gene2458	3.017e-87	303.0	COG1785@1|root,COG1785@2|Bacteria,4NG3D@976|Bacteroidetes,1IPXF@117747|Sphingobacteriia	976|Bacteroidetes	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
DTH2_k127_2083418_3	1499967.BAYZ01000177_gene5729	9.292e-67	240.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
DTH2_k127_2083418_7	368408.Tpen_1540	2.198e-07	59.0	arCOG04797@1|root,arCOG04797@2157|Archaea,2XS23@28889|Crenarchaeota	28889|Crenarchaeota	S	retrograde transport, endosome to Golgi	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2083418_2	1499967.BAYZ01000039_gene2222	3.522e-68	238.0	COG0558@1|root,COG0558@2|Bacteria,2NPXW@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.34	ko:K07291	ko00562,map00562	-	R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DTH2_k127_2083418_5	1123009.AUID01000024_gene1455	4.72e-30	124.0	2E12M@1|root,32WIA@2|Bacteria,1VD2B@1239|Firmicutes,24NKB@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2083418_4	349163.Acry_0945	1.163e-62	220.0	COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2TSEQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Amino_oxidase,FAD_binding_3,Pyr_redox_2
DTH2_k127_2089819_0	247490.KSU1_C0507	5.702e-100	346.0	COG1361@1|root,COG1361@2|Bacteria,2IY9X@203682|Planctomycetes	203682|Planctomycetes	M	60 kDa outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
DTH2_k127_2089819_1	1411685.U062_01308	3.998e-90	305.0	COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1T1SF@1236|Gammaproteobacteria,1J5SF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0668 Small-conductance mechanosensitive channel	mscS	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
DTH2_k127_2089819_3	929556.Solca_0320	1.274e-47	177.0	COG3005@1|root,COG3005@2|Bacteria,4NK7R@976|Bacteroidetes	976|Bacteroidetes	C	cytochrome c nitrate reductase, small subunit	nrfH	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
DTH2_k127_2089819_2	945713.IALB_0861	6.677e-85	291.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z5669	Cytochrom_C552
DTH2_k127_2096363_1	335543.Sfum_2564	3.061e-111	373.0	COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MR7F@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
DTH2_k127_2096363_0	536227.CcarbDRAFT_2958	9.798e-161	527.0	COG1018@1|root,COG3894@1|root,COG1018@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,36DDZ@31979|Clostridiaceae	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
DTH2_k127_2096363_2	646529.Desaci_3572	1.877e-19	95.0	COG1456@1|root,COG1456@2|Bacteria,1UIEM@1239|Firmicutes,25EJY@186801|Clostridia,267AU@186807|Peptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
DTH2_k127_2107136_1	1235813.JCM10003_1818	4.117e-14	79.0	COG0845@1|root,COG0845@2|Bacteria,4NF23@976|Bacteroidetes,2FMQJ@200643|Bacteroidia,4ANJN@815|Bacteroidaceae	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
DTH2_k127_2107136_0	760568.Desku_0101	6.823e-220	708.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,260X3@186807|Peptococcaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
DTH2_k127_2121173_2	697281.Mahau_1819	4.176e-09	60.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_2121173_0	313628.LNTAR_06789	3.652e-83	294.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2,MFS_3
DTH2_k127_2121173_1	794903.OPIT5_28305	4.708e-13	69.0	COG1069@1|root,COG1069@2|Bacteria,46UI3@74201|Verrucomicrobia,3K769@414999|Opitutae	414999|Opitutae	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
DTH2_k127_21258_1	1047013.AQSP01000071_gene1933	1.927e-35	156.0	COG0768@1|root,COG0768@2|Bacteria,2NNYI@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding protein 2	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
DTH2_k127_21258_2	754477.Q7C_1177	4.874e-09	66.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,460NI@72273|Thiotrichales	72273|Thiotrichales	M	Involved in formation and maintenance of cell shape	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
DTH2_k127_21258_0	1142394.PSMK_14530	6.065e-159	507.0	COG1077@1|root,COG1077@2|Bacteria,2IXSJ@203682|Planctomycetes	203682|Planctomycetes	D	COG1077 Actin-like ATPase involved in cell morphogenesis	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
DTH2_k127_218753_2	530564.Psta_3376	5.086e-81	289.0	COG0454@1|root,COG1181@1|root,COG0456@2|Bacteria,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
DTH2_k127_218753_0	756272.Plabr_4556	2.663e-104	348.0	COG1181@1|root,COG1181@2|Bacteria,2IYQF@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
DTH2_k127_218753_1	1304875.JAFZ01000003_gene569	1.323e-87	295.0	COG1509@1|root,COG1509@2|Bacteria,3TAK3@508458|Synergistetes	508458|Synergistetes	C	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_14,LAM_C,Radical_SAM
DTH2_k127_221401_3	1266925.JHVX01000009_gene141	7.257e-15	78.0	COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,2VJS1@28216|Betaproteobacteria,371M8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
DTH2_k127_221401_1	1266925.JHVX01000009_gene140	9.762e-48	175.0	COG0226@1|root,COG0226@2|Bacteria,1N19C@1224|Proteobacteria,2VWK2@28216|Betaproteobacteria,3735X@32003|Nitrosomonadales	28216|Betaproteobacteria	P	COG0226 ABC-type phosphate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_221401_0	1288494.EBAPG3_25820	3.771e-88	299.0	COG3176@1|root,COG3176@2|Bacteria,1QXHI@1224|Proteobacteria,2WH4C@28216|Betaproteobacteria,372K9@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
DTH2_k127_221401_2	323848.Nmul_A2625	1.318e-35	135.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,3736C@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
DTH2_k127_2219707_0	886293.Sinac_6469	6.368e-157	504.0	COG0436@1|root,COG0436@2|Bacteria,2IY66@203682|Planctomycetes	203682|Planctomycetes	E	aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH2_k127_2219707_1	106370.Francci3_3607	6.351e-25	112.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4ERTE@85013|Frankiales	201174|Actinobacteria	L	nucleic acid binding OB-fold tRNA helicase-type	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
DTH2_k127_2219730_4	929562.Emtol_2073	3.401e-05	48.0	COG1086@1|root,COG1086@2|Bacteria,4NERY@976|Bacteroidetes,47KE5@768503|Cytophagia	976|Bacteroidetes	GM	Polysaccharide biosynthesis protein	cap5D	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
DTH2_k127_2219730_3	526222.Desal_0067	1.731e-24	108.0	COG0216@1|root,COG0216@2|Bacteria,1R348@1224|Proteobacteria,43DJ0@68525|delta/epsilon subdivisions,2X8QA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
DTH2_k127_2219730_0	237368.SCABRO_01933	1.41e-161	522.0	COG0034@1|root,COG0034@2|Bacteria,2IXKC@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
DTH2_k127_2219730_1	1142394.PSMK_01400	2.641e-124	407.0	COG0150@1|root,COG0150@2|Bacteria,2IYCG@203682|Planctomycetes	203682|Planctomycetes	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DTH2_k127_2219730_2	1071073.KI530537_gene2154	2.702e-30	123.0	COG0730@1|root,COG0730@2|Bacteria,1VUUX@1239|Firmicutes,4HVXT@91061|Bacilli,1ZG54@1386|Bacillus	91061|Bacilli	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
DTH2_k127_2252766_2	889378.Spiaf_0588	2.705e-05	47.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
DTH2_k127_2252766_1	1341151.ASZU01000004_gene331	2.244e-56	212.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4HAEV@91061|Bacilli,27BGU@186824|Thermoactinomycetaceae	91061|Bacilli	D	Cell cycle protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
DTH2_k127_2252766_0	865938.Weevi_1212	3.117e-86	295.0	COG1158@1|root,COG1158@2|Bacteria,4NEFP@976|Bacteroidetes,1HX0N@117743|Flavobacteriia	976|Bacteroidetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
DTH2_k127_2275077_3	880073.Calab_2103	5.736e-35	139.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
DTH2_k127_2275077_1	385682.AFSL01000047_gene522	8.951e-102	341.0	COG2025@1|root,COG2025@2|Bacteria,4NFSE@976|Bacteroidetes,2FMEK@200643|Bacteroidia,3XJ83@558415|Marinilabiliaceae	976|Bacteroidetes	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
DTH2_k127_2275077_0	880073.Calab_2105	1.134e-160	526.0	COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria	2|Bacteria	I	Dehydrogenase	acd	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0052890,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249,ko:K20035	ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
DTH2_k127_2383980_0	868595.Desca_1038	7.871e-107	355.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,25ZYB@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
DTH2_k127_2383980_1	1144305.PMI02_04498	2.158e-07	60.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria,2K7DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
DTH2_k127_241456_2	1121011.AUCB01000031_gene2194	2.377e-107	362.0	2E5U1@1|root,330IC@2|Bacteria	2|Bacteria	S	Sugar-binding cellulase-like	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase-like
DTH2_k127_241456_4	446470.Snas_6020	1.714e-30	140.0	2E809@1|root,332EJ@2|Bacteria,2H3RK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_241456_6	234267.Acid_4759	2.209e-09	62.0	COG2377@1|root,COG2377@2|Bacteria,3Y3CU@57723|Acidobacteria	57723|Acidobacteria	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
DTH2_k127_241456_0	1122605.KB893625_gene1731	2.079e-141	458.0	COG0438@1|root,COG0438@2|Bacteria,4PMP0@976|Bacteroidetes,1ISE4@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycosyltransferase WbsX	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX
DTH2_k127_241456_3	667014.Thein_1022	2.17e-38	156.0	COG0535@1|root,COG0535@2|Bacteria,2GIGC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_241456_1	1142394.PSMK_24340	1.573e-115	385.0	COG0515@1|root,COG0515@2|Bacteria,2IYFB@203682|Planctomycetes	203682|Planctomycetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
DTH2_k127_241456_5	658088.HMPREF0987_02059	1.942e-11	69.0	COG1309@1|root,COG1309@2|Bacteria,1V1C8@1239|Firmicutes,24FZ9@186801|Clostridia,27J06@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
DTH2_k127_2423556_3	59894.ENSFALP00000014370	2.361e-10	63.0	2AB8N@1|root,2RYNR@2759|Eukaryota,39TQ5@33154|Opisthokonta,3BN5V@33208|Metazoa,3D0PR@33213|Bilateria,485YH@7711|Chordata,4929C@7742|Vertebrata,4GK84@8782|Aves	33208|Metazoa	S	Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle	ELN	GO:0001101,GO:0001568,GO:0001666,GO:0001944,GO:0001974,GO:0003007,GO:0003008,GO:0003013,GO:0003151,GO:0003170,GO:0003176,GO:0003179,GO:0003180,GO:0003674,GO:0005198,GO:0005201,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0006950,GO:0006996,GO:0007010,GO:0007015,GO:0007154,GO:0007275,GO:0007507,GO:0007517,GO:0007519,GO:0007568,GO:0007584,GO:0007585,GO:0008015,GO:0008064,GO:0008150,GO:0008283,GO:0009410,GO:0009605,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009743,GO:0009887,GO:0009888,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0014070,GO:0014706,GO:0016043,GO:0022607,GO:0030023,GO:0030029,GO:0030036,GO:0030038,GO:0030198,GO:0030832,GO:0030833,GO:0031012,GO:0031032,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031960,GO:0032271,GO:0032501,GO:0032502,GO:0032526,GO:0032535,GO:0032870,GO:0032956,GO:0032970,GO:0033043,GO:0033273,GO:0033554,GO:0033591,GO:0033993,GO:0034284,GO:0035690,GO:0035904,GO:0036293,GO:0036294,GO:0036296,GO:0042221,GO:0042493,GO:0043062,GO:0043149,GO:0043254,GO:0044085,GO:0044087,GO:0044344,GO:0044420,GO:0044421,GO:0046688,GO:0048251,GO:0048513,GO:0048545,GO:0048731,GO:0048771,GO:0048856,GO:0050789,GO:0050794,GO:0050840,GO:0050896,GO:0051017,GO:0051128,GO:0051384,GO:0051493,GO:0051716,GO:0055093,GO:0060537,GO:0060538,GO:0060840,GO:0061061,GO:0061572,GO:0065007,GO:0065008,GO:0070482,GO:0070848,GO:0070887,GO:0071229,GO:0071241,GO:0071248,GO:0071280,GO:0071295,GO:0071298,GO:0071300,GO:0071310,GO:0071322,GO:0071326,GO:0071363,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071453,GO:0071456,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071559,GO:0071560,GO:0071774,GO:0071840,GO:0071953,GO:0072358,GO:0072359,GO:0085029,GO:0090066,GO:0097327,GO:0097435,GO:0097493,GO:0110053,GO:1901654,GO:1901655,GO:1901700,GO:1901701,GO:1902903,GO:1905314	-	ko:K14211	ko04974,map04974	-	-	-	ko00000,ko00001	-	-	-	-
DTH2_k127_2423556_0	1121396.KB893094_gene4459	3.859e-47	176.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,zf-NADH-PPase
DTH2_k127_2423556_1	344747.PM8797T_12443	3.934e-19	93.0	COG3682@1|root,COG3682@2|Bacteria,2J12Z@203682|Planctomycetes	203682|Planctomycetes	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
DTH2_k127_2423556_2	1123242.JH636434_gene4692	4.583e-18	95.0	COG3170@1|root,COG4219@1|root,COG3170@2|Bacteria,COG4219@2|Bacteria,2J20Z@203682|Planctomycetes	203682|Planctomycetes	KNU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2434085_9	530564.Psta_3634	6.844e-38	152.0	COG4796@1|root,COG4796@2|Bacteria,2IY1C@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the GSP D family	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	STN,Secretin
DTH2_k127_2434085_16	498211.CJA_3419	8.47e-06	58.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1FG44@10|Cellvibrio	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_14,TPR_16,TPR_19,TPR_4,TPR_6,TPR_8
DTH2_k127_2434085_3	868595.Desca_2305	4.865e-67	246.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,260MY@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
DTH2_k127_2434085_12	530564.Psta_3636	5.649e-28	119.0	COG0745@1|root,COG0745@2|Bacteria,2J15S@203682|Planctomycetes	203682|Planctomycetes	T	PFAM response regulator receiver	-	-	-	ko:K11329	ko02020,map02020	M00467	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
DTH2_k127_2434085_5	530564.Psta_2798	3.363e-61	231.0	COG2206@1|root,COG2206@2|Bacteria,2IWTK@203682|Planctomycetes	203682|Planctomycetes	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,HD
DTH2_k127_2434085_15	521674.Plim_0427	3.617e-09	63.0	COG1366@1|root,COG1366@2|Bacteria,2J0R5@203682|Planctomycetes	203682|Planctomycetes	T	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
DTH2_k127_2434085_0	521674.Plim_0426	1.178e-201	642.0	COG2804@1|root,COG2804@2|Bacteria,2IX4I@203682|Planctomycetes	203682|Planctomycetes	NU	COG2804 Type II secretory pathway ATPase PulE Tfp pilus assembly pathway ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DTH2_k127_2434085_4	314230.DSM3645_24020	4.05e-65	237.0	COG1459@1|root,COG1459@2|Bacteria,2IYHA@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DTH2_k127_2434085_13	1210884.HG799463_gene10266	4.142e-21	96.0	COG0227@1|root,COG0227@2|Bacteria,2J0SS@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
DTH2_k127_2434085_10	309799.DICTH_1787	5.923e-37	144.0	COG1433@1|root,COG1433@2|Bacteria	2|Bacteria	S	nitrogen fixation	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
DTH2_k127_2434085_1	1499967.BAYZ01000174_gene5829	1.103e-190	609.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	Thioredoxin_3,URO-D
DTH2_k127_2434085_8	1499967.BAYZ01000056_gene4870	1.019e-39	159.0	COG0523@1|root,COG0523@2|Bacteria	2|Bacteria	P	cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
DTH2_k127_2434085_14	938278.CAJO01000044_gene235	8.505e-15	77.0	COG1254@1|root,COG1254@2|Bacteria,1VEM9@1239|Firmicutes,24QXB@186801|Clostridia	186801|Clostridia	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
DTH2_k127_2434085_2	237368.SCABRO_03725	2.198e-167	533.0	COG1697@1|root,COG1697@2|Bacteria,2J34C@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
DTH2_k127_2434085_6	1142394.PSMK_29570	2.522e-58	210.0	COG0325@1|root,COG0325@2|Bacteria,2IZ9R@203682|Planctomycetes	203682|Planctomycetes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
DTH2_k127_2434085_11	1123508.JH636440_gene2373	1.464e-36	153.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,2J0ZD@203682|Planctomycetes	203682|Planctomycetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
DTH2_k127_2434085_7	330214.NIDE0571	7.222e-48	173.0	COG3169@1|root,COG3169@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
DTH2_k127_2463244_3	243090.RB7168	9.048e-24	102.0	COG0236@1|root,COG0236@2|Bacteria,2J04I@203682|Planctomycetes	203682|Planctomycetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
DTH2_k127_2463244_1	1123242.JH636436_gene228	1.827e-40	154.0	COG0764@1|root,COG0764@2|Bacteria,2J09I@203682|Planctomycetes	203682|Planctomycetes	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
DTH2_k127_2463244_4	88036.EFJ14928	2.73e-22	103.0	28IXY@1|root,2QR9K@2759|Eukaryota,37S7Y@33090|Viridiplantae,3GG0F@35493|Streptophyta	35493|Streptophyta	S	late embryogenesis abundant protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
DTH2_k127_2463244_0	1123274.KB899416_gene2670	6.814e-152	491.0	COG0019@1|root,COG0019@2|Bacteria,2J5HV@203691|Spirochaetes	203691|Spirochaetes	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
DTH2_k127_2463244_2	1396141.BATP01000033_gene4246	1.896e-40	158.0	COG2143@1|root,COG2143@2|Bacteria,46Z6E@74201|Verrucomicrobia,2IW7D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
DTH2_k127_251833_1	886293.Sinac_2703	5.615e-87	298.0	COG0240@1|root,COG0240@2|Bacteria,2IWWN@203682|Planctomycetes	203682|Planctomycetes	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
DTH2_k127_251833_3	999411.HMPREF1092_00748	3.842e-06	62.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,36E5E@31979|Clostridiaceae	186801|Clostridia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
DTH2_k127_251833_2	545695.TREAZ_2314	5.291e-54	197.0	COG0637@1|root,COG0637@2|Bacteria,2J814@203691|Spirochaetes	203691|Spirochaetes	F	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	HAD_2,dCMP_cyt_deam_1
DTH2_k127_251833_0	1142394.PSMK_24980	2.796e-99	333.0	COG0472@1|root,COG0472@2|Bacteria,2IXU1@203682|Planctomycetes	203682|Planctomycetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4
DTH2_k127_2561118_2	350688.Clos_0204	7.438e-09	57.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,36EVK@31979|Clostridiaceae	186801|Clostridia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
DTH2_k127_2561118_0	1195236.CTER_5360	5.299e-257	823.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolases family 38 C-terminal domain	mngB	-	3.2.1.170	ko:K15524	-	-	-	-	ko00000,ko01000	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
DTH2_k127_2561118_1	1236976.JCM16418_4253	6.279e-09	59.0	COG1409@1|root,COG2041@1|root,COG3211@1|root,COG4733@1|root,COG1409@2|Bacteria,COG2041@2|Bacteria,COG3211@2|Bacteria,COG4733@2|Bacteria,1V7PQ@1239|Firmicutes,4IUC5@91061|Bacilli,277JF@186822|Paenibacillaceae	91061|Bacilli	G	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,SLH,fn3
DTH2_k127_2582958_1	443143.GM18_1541	2.449e-84	291.0	COG1409@1|root,COG3204@1|root,COG1409@2|Bacteria,COG3204@2|Bacteria,1N85S@1224|Proteobacteria,42WZ6@68525|delta/epsilon subdivisions,2WT5K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_C,PKD,Pur_ac_phosph_N
DTH2_k127_2582958_0	768706.Desor_2109	3.408e-116	385.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,2601Y@186807|Peptococcaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
DTH2_k127_2582958_2	755732.Fluta_2742	1.059e-05	56.0	COG2356@1|root,COG4085@1|root,COG2356@2|Bacteria,COG4085@2|Bacteria	2|Bacteria	S	PFAM nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1,Exo_endo_phos,PLDc_2,Trypsin_2
DTH2_k127_2593558_2	203119.Cthe_1283	2.671e-76	261.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,3WGWR@541000|Ruminococcaceae	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
DTH2_k127_2593558_3	488538.SAR116_0594	1.607e-41	167.0	COG3239@1|root,COG3239@2|Bacteria,1R42Z@1224|Proteobacteria,2TU07@28211|Alphaproteobacteria,4BSTA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
DTH2_k127_2593558_1	344747.PM8797T_04520	6.651e-79	281.0	COG0593@1|root,COG0593@2|Bacteria,2IWXU@203682|Planctomycetes	203682|Planctomycetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
DTH2_k127_2593558_0	1142394.PSMK_22770	1.038e-160	522.0	COG0029@1|root,COG0029@2|Bacteria,2IY30@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
DTH2_k127_2593558_4	1323663.AROI01000005_gene3033	1.749e-07	55.0	2EFT3@1|root,339J3@2|Bacteria,1NH28@1224|Proteobacteria,1SI3W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2594081_1	696281.Desru_0362	1.651e-160	516.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,2617C@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
DTH2_k127_2594081_0	234267.Acid_5704	9.12e-195	620.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iYO844.BSU28280	HMGL-like,LeuA_dimer
DTH2_k127_2594081_4	1499967.BAYZ01000068_gene1977	2.994e-84	286.0	COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
DTH2_k127_2594081_3	1142394.PSMK_13910	1.158e-112	370.0	COG0040@1|root,COG0040@2|Bacteria,2IXEV@203682|Planctomycetes	203682|Planctomycetes	F	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
DTH2_k127_2594081_6	530564.Psta_4659	2.518e-09	67.0	COG0177@1|root,COG0177@2|Bacteria,2IZDJ@203682|Planctomycetes	203682|Planctomycetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
DTH2_k127_2594081_5	1449126.JQKL01000001_gene1379	3.377e-10	67.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,2692J@186813|unclassified Clostridiales	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
DTH2_k127_2594081_2	247490.KSU1_D0820	1.345e-114	379.0	COG0532@1|root,COG0532@2|Bacteria,2IXYU@203682|Planctomycetes	203682|Planctomycetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
DTH2_k127_2611832_0	1121403.AUCV01000018_gene3190	2.68e-151	492.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42QVZ@68525|delta/epsilon subdivisions,2WMVN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
DTH2_k127_2616617_8	794903.OPIT5_12135	4.781e-21	98.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,F5_F8_type_C,Pectate_lyase_3
DTH2_k127_2616617_4	877414.ATWA01000053_gene515	1.702e-75	269.0	2EXVG@1|root,33R4M@2|Bacteria,1VR8B@1239|Firmicutes,24XZS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2616617_1	180332.JTGN01000004_gene2606	3.079e-110	367.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24KSS@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_2616617_3	794903.OPIT5_20440	4.228e-95	335.0	COG5434@1|root,COG5434@2|Bacteria,46Y9S@74201|Verrucomicrobia,3K96M@414999|Opitutae	414999|Opitutae	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
DTH2_k127_2616617_9	1123009.AUID01000001_gene1005	1.106e-09	61.0	2DR7G@1|root,33AJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2616617_0	1111479.AXAR01000001_gene15	2.483e-186	604.0	COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,4HA88@91061|Bacilli,279B6@186823|Alicyclobacillaceae	91061|Bacilli	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
DTH2_k127_2616617_2	1307761.L21SP2_3482	4.16e-101	348.0	COG0248@1|root,COG0248@2|Bacteria,2J5XU@203691|Spirochaetes	203691|Spirochaetes	FP	Ppx GppA phosphatase family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
DTH2_k127_2616617_7	398767.Glov_0592	1.871e-31	131.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria	28221|Deltaproteobacteria	FP	Ppx GppA phosphatase	gppA-2	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
DTH2_k127_2616617_6	472759.Nhal_3072	3.903e-49	188.0	COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria	1224|Proteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
DTH2_k127_2616617_5	1121403.AUCV01000001_gene700	1.512e-74	254.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria,2MJ9S@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-1	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DTH2_k127_2666709_2	1347392.CCEZ01000075_gene3171	7.205e-27	116.0	COG1670@1|root,COG1670@2|Bacteria,1V7UX@1239|Firmicutes,24IDY@186801|Clostridia,36J33@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,Acetyltransf_4
DTH2_k127_2666709_1	1536774.H70357_28085	2.93e-58	218.0	COG1250@1|root,COG1250@2|Bacteria,1TR8J@1239|Firmicutes,4H9XN@91061|Bacilli,26TYA@186822|Paenibacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32840	3HCDH,3HCDH_N,ECH_1
DTH2_k127_2666709_3	382464.ABSI01000014_gene1428	3.346e-22	100.0	2CCSR@1|root,32RWC@2|Bacteria,46XSI@74201|Verrucomicrobia,2IWGZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
DTH2_k127_2666709_0	566466.NOR53_3092	1.797e-60	214.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1RRAB@1236|Gammaproteobacteria,1J8KS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DTH2_k127_2712357_3	1142394.PSMK_11820	3.47e-71	248.0	COG2019@1|root,COG2019@2|Bacteria	2|Bacteria	F	adenylate kinase activity	-	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
DTH2_k127_2712357_6	886293.Sinac_4931	4.464e-26	117.0	COG3848@1|root,COG3848@2|Bacteria,2IZTQ@203682|Planctomycetes	203682|Planctomycetes	T	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2712357_1	398511.BpOF4_03780	2.464e-138	450.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,4H9YV@91061|Bacilli,1ZBY9@1386|Bacillus	91061|Bacilli	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
DTH2_k127_2712357_4	192952.MM_0946	3.701e-49	183.0	COG1853@1|root,arCOG02016@2157|Archaea,2XYAJ@28890|Euryarchaeota,2N9RF@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DTH2_k127_2712357_2	1499967.BAYZ01000095_gene4075	1.971e-87	296.0	COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
DTH2_k127_2712357_5	386456.JQKN01000004_gene225	2.812e-36	141.0	COG2050@1|root,arCOG00777@2157|Archaea,2XXGC@28890|Euryarchaeota,23PW5@183925|Methanobacteria	183925|Methanobacteria	Q	PFAM Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
DTH2_k127_2712357_0	1142394.PSMK_03880	6.658e-266	829.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DTH2_k127_2764873_0	1142394.PSMK_24160	4.543e-128	435.0	COG1674@1|root,COG1674@2|Bacteria,2IXHF@203682|Planctomycetes	203682|Planctomycetes	D	COG1674 DNA segregation ATPase FtsK SpoIIIE and related	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
DTH2_k127_2764873_1	1234664.AMRO01000028_gene1512	4.873e-51	183.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,1WEZ2@129337|Geobacillus	91061|Bacilli	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DTH2_k127_2790132_1	290318.Cvib_0160	1.157e-34	144.0	COG1462@1|root,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
DTH2_k127_2790132_0	1123508.JH636443_gene4950	4.335e-71	253.0	COG0617@1|root,COG0617@2|Bacteria,2IXYM@203682|Planctomycetes	203682|Planctomycetes	H	tRNA nucleotidyltransferase poly(A) polymerase	papS	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
DTH2_k127_2798438_2	1487921.DP68_15265	7.359e-65	235.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,36E1G@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the peptidase M24B family	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
DTH2_k127_2798438_6	717231.Flexsi_0315	5.857e-17	84.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
DTH2_k127_2798438_4	521045.Kole_0232	5.722e-33	132.0	COG2361@1|root,COG2361@2|Bacteria,2GDEF@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
DTH2_k127_2798438_5	391616.OA238_c16860	2.391e-28	122.0	2ECEJ@1|root,336CU@2|Bacteria,1N0XT@1224|Proteobacteria,2UUDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2798438_1	1123242.JH636434_gene4081	6.259e-166	534.0	COG0422@1|root,COG0422@2|Bacteria,2IWV7@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
DTH2_k127_2798438_0	1121904.ARBP01000028_gene1710	1.431e-183	584.0	COG0673@1|root,COG0673@2|Bacteria,4NIF1@976|Bacteroidetes,47JIW@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DTH2_k127_2798438_3	1123242.JH636435_gene2593	1.859e-44	167.0	COG0673@1|root,COG0673@2|Bacteria,2IXFW@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_286028_1	1254432.SCE1572_50535	1.285e-110	368.0	COG1879@1|root,COG1879@2|Bacteria,1MU95@1224|Proteobacteria	1224|Proteobacteria	G	Periplasmic binding protein LacI transcriptional regulator	alsB	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
DTH2_k127_286028_0	1396141.BATP01000025_gene970	6.136e-160	516.0	COG1129@1|root,COG1129@2|Bacteria,46SG6@74201|Verrucomicrobia,2IV5X@203494|Verrucomicrobiae	2|Bacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DTH2_k127_2904118_1	1499967.BAYZ01000075_gene2071	7.194e-72	263.0	COG1925@1|root,COG1925@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS-HPr
DTH2_k127_2904118_0	56780.SYN_00429	1.48e-77	267.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42R8B@68525|delta/epsilon subdivisions,2X5KI@28221|Deltaproteobacteria,2MR8C@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
DTH2_k127_293243_0	247490.KSU1_C0416	1.401e-154	501.0	COG0749@1|root,COG0749@2|Bacteria,2IXQR@203682|Planctomycetes	203682|Planctomycetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
DTH2_k127_293243_2	614083.AWQR01000047_gene3278	4.571e-32	136.0	COG2197@1|root,COG2197@2|Bacteria,1RH8D@1224|Proteobacteria,2WEH4@28216|Betaproteobacteria,4AIYX@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DTH2_k127_293243_1	1047013.AQSP01000130_gene1869	7.522e-113	394.0	COG3250@1|root,COG3250@2|Bacteria,2NNR1@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 2	bmnA	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DTH2_k127_2949169_2	1158294.JOMI01000005_gene3184	2.886e-13	75.0	2C6HF@1|root,32XWI@2|Bacteria,4NU6D@976|Bacteroidetes,2G2JK@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2949169_1	1047013.AQSP01000114_gene693	3.372e-24	108.0	2E74N@1|root,331P2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2949169_0	635013.TherJR_1006	2.076e-116	404.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,2606F@186807|Peptococcaceae	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
DTH2_k127_2957505_4	1519464.HY22_03120	1.768e-42	161.0	COG1335@1|root,COG1335@2|Bacteria,1FE0F@1090|Chlorobi	1090|Chlorobi	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
DTH2_k127_2957505_1	661478.OP10G_2391	1.565e-131	438.0	COG1409@1|root,COG3669@1|root,COG1409@2|Bacteria,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C,PA14
DTH2_k127_2957505_2	526222.Desal_1779	1.632e-127	419.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,2M9KQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Belongs to the methyltransferase superfamily	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
DTH2_k127_2957505_0	1209989.TepiRe1_1688	1.078e-135	444.0	COG5026@1|root,COG5026@2|Bacteria,1TRWA@1239|Firmicutes,24BV4@186801|Clostridia	186801|Clostridia	G	PFAM hexokinase	-	-	2.7.1.1	ko:K00844	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04910,ko04930,ko04973,ko05230,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200,map04066,map04910,map04930,map04973,map05230	M00001,M00549	R00299,R00760,R00867,R01326,R01600,R01786,R01961,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	Hexokinase_1,Hexokinase_2
DTH2_k127_2957505_3	203119.Cthe_0186	6.267e-118	388.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,3WGFI@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
DTH2_k127_3001999_3	1499680.CCFE01000011_gene321	4.528e-65	234.0	COG0189@1|root,COG0189@2|Bacteria,1UIBP@1239|Firmicutes,4HDB7@91061|Bacilli,1ZDUR@1386|Bacillus	91061|Bacilli	HJ	ATP-grasp domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3
DTH2_k127_3001999_0	530564.Psta_0769	9.1e-123	409.0	COG0621@1|root,COG0621@2|Bacteria,2IX1E@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
DTH2_k127_3001999_5	401053.AciPR4_1258	5.894e-11	65.0	29WS1@1|root,30ID4@2|Bacteria,3Y5IE@57723|Acidobacteria,2JK0W@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
DTH2_k127_3001999_4	243090.RB3174	1.045e-57	210.0	COG1187@1|root,COG1187@2|Bacteria,2IYUS@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DTH2_k127_3001999_2	1499967.BAYZ01000176_gene5632	7.411e-68	235.0	COG0693@1|root,COG0693@2|Bacteria,2NRMH@2323|unclassified Bacteria	2|Bacteria	S	DJ-1/PfpI family	thiJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009100,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019538,GO:0022613,GO:0030091,GO:0033554,GO:0034599,GO:0036211,GO:0036524,GO:0036525,GO:0042026,GO:0042221,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K05687,ko:K12132	ko05012,map05012	-	-	-	ko00000,ko00001,ko01000,ko01001,ko01002,ko04147	-	-	-	DJ-1_PfpI
DTH2_k127_3001999_1	879212.DespoDRAFT_01295	4.387e-77	270.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFQ@28221|Deltaproteobacteria,2MIXP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
DTH2_k127_3005451_3	266264.Rmet_5699	0.0001101	52.0	COG1462@1|root,COG1462@2|Bacteria,1RH5B@1224|Proteobacteria,2VWV9@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
DTH2_k127_3005451_1	319225.Plut_0084	1.552e-62	221.0	COG3417@1|root,COG3417@2|Bacteria	2|Bacteria	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
DTH2_k127_3005451_2	290318.Cvib_0157	1.892e-08	62.0	COG5633@1|root,COG5633@2|Bacteria	2|Bacteria	S	Lipoprotein	ycfL	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	-	-	-	-	-	-	-	-	-	DUF1425
DTH2_k127_3005451_0	319225.Plut_0082	4.853e-90	317.0	COG3014@1|root,COG3014@2|Bacteria,1FFNE@1090|Chlorobi	1090|Chlorobi	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
DTH2_k127_3007765_4	1304880.JAGB01000001_gene542	1.893e-59	220.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_3007765_3	1142394.PSMK_16280	4.649e-61	223.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
DTH2_k127_3007765_2	313628.LNTAR_06789	2.055e-89	312.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2,MFS_3
DTH2_k127_3007765_0	697281.Mahau_2278	1.846e-263	827.0	COG1874@1|root,COG1874@2|Bacteria,1TT9J@1239|Firmicutes,24CY9@186801|Clostridia,42HX5@68295|Thermoanaerobacterales	186801|Clostridia	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
DTH2_k127_3007765_1	935948.KE386494_gene320	5.684e-107	353.0	COG0407@1|root,COG0407@2|Bacteria,1UZSW@1239|Firmicutes,24E13@186801|Clostridia,42IBM@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_3008837_0	886293.Sinac_4828	9.092e-145	466.0	COG0498@1|root,COG0498@2|Bacteria,2IXKE@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH2_k127_3008837_2	1379698.RBG1_1C00001G0843	5.117e-17	91.0	COG1011@1|root,COG1011@2|Bacteria,2NQ1K@2323|unclassified Bacteria	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH2_k127_3008837_1	509191.AEDB02000066_gene756	6.443e-45	167.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,3WGUB@541000|Ruminococcaceae	186801|Clostridia	E	Pyruvate carboxyltransferase	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03250	HMGL-like
DTH2_k127_3026871_1	237368.SCABRO_03849	5.124e-80	280.0	COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes	203682|Planctomycetes	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
DTH2_k127_3026871_0	338963.Pcar_2750	8.022e-86	291.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,43UPV@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
DTH2_k127_3026871_2	338963.Pcar_2751	3.221e-46	179.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,42SPY@68525|delta/epsilon subdivisions,2WP3D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
DTH2_k127_3026871_3	1120999.JONM01000019_gene3408	3.747e-12	75.0	COG3009@1|root,COG3009@2|Bacteria,1PVB5@1224|Proteobacteria,2VYE2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_aux
DTH2_k127_3084695_2	439235.Dalk_3005	1.815e-05	49.0	COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MJYE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_3084695_0	1321778.HMPREF1982_01682	6.959e-185	587.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,26AI4@186813|unclassified Clostridiales	186801|Clostridia	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
DTH2_k127_3084695_1	247490.KSU1_C0978	6.86e-97	327.0	COG0550@1|root,COG0550@2|Bacteria,2IY53@203682|Planctomycetes	203682|Planctomycetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
DTH2_k127_3086750_4	909663.KI867149_gene3179	1.285e-41	154.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2MR97@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
DTH2_k127_3086750_2	203119.Cthe_0115	6.915e-138	462.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,249BI@186801|Clostridia	186801|Clostridia	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
DTH2_k127_3086750_1	563192.HMPREF0179_03201	3.567e-161	516.0	COG1449@1|root,COG1449@2|Bacteria,1R8JX@1224|Proteobacteria,42QA5@68525|delta/epsilon subdivisions,2WMM5@28221|Deltaproteobacteria,2M9GJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
DTH2_k127_3086750_3	665942.HMPREF1022_02705	2.333e-122	407.0	COG0297@1|root,COG0297@2|Bacteria,1R6U0@1224|Proteobacteria,42Q1W@68525|delta/epsilon subdivisions,2WJXW@28221|Deltaproteobacteria,2M8ZZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
DTH2_k127_3086750_0	575540.Isop_1279	2.313e-172	546.0	COG0473@1|root,COG0473@2|Bacteria,2IXBE@203682|Planctomycetes	203682|Planctomycetes	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH2_k127_3086750_5	1123242.JH636434_gene5451	2.452e-12	69.0	COG1663@1|root,COG1663@2|Bacteria,2IXYX@203682|Planctomycetes	203682|Planctomycetes	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
DTH2_k127_3099302_0	1232437.KL662016_gene1081	2.131e-173	548.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,42MPB@68525|delta/epsilon subdivisions,2WJUV@28221|Deltaproteobacteria,2MJ5P@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH2_k127_3099302_1	177439.DP2964	2.673e-17	85.0	COG2973@1|root,COG2973@2|Bacteria,1R3GJ@1224|Proteobacteria,43DK9@68525|delta/epsilon subdivisions,2X8RF@28221|Deltaproteobacteria,2MPQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Trp repressor protein	-	-	-	ko:K03720	-	-	-	-	ko00000,ko03000	-	-	-	Trp_repressor
DTH2_k127_3099302_2	697281.Mahau_0403	0.0002311	48.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,42H30@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
DTH2_k127_3127870_5	1280666.ATVS01000009_gene1238	8.863e-38	156.0	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,4BWC6@830|Butyrivibrio	186801|Clostridia	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
DTH2_k127_3127870_3	521674.Plim_0080	1.064e-62	233.0	COG1774@1|root,COG1774@2|Bacteria,2IWZD@203682|Planctomycetes	203682|Planctomycetes	S	signal peptidase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
DTH2_k127_3127870_1	472759.Nhal_2751	1.492e-248	784.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
DTH2_k127_3127870_7	344747.PM8797T_22188	1.62e-19	93.0	2E5IJ@1|root,3309Y@2|Bacteria,2J0P5@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3127870_4	671143.DAMO_0882	3.224e-46	176.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
DTH2_k127_3127870_6	237368.SCABRO_03511	5.287e-23	106.0	COG0558@1|root,COG0558@2|Bacteria,2J36U@203682|Planctomycetes	203682|Planctomycetes	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
DTH2_k127_3127870_2	269799.Gmet_1626	1.378e-150	486.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,43U14@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
DTH2_k127_3127870_0	522306.CAP2UW1_1124	4.793e-251	785.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,2VJKF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
DTH2_k127_3127870_8	1121875.KB907549_gene1997	5.165e-14	74.0	COG3408@1|root,COG3408@2|Bacteria,4PKJG@976|Bacteroidetes,1IJAW@117743|Flavobacteriia	976|Bacteroidetes	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
DTH2_k127_3158384_0	886293.Sinac_5147	6.951e-76	267.0	COG0013@1|root,COG0013@2|Bacteria,2IX30@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DTH2_k127_3158384_1	755178.Cyan10605_1644	7.509e-53	192.0	COG1943@1|root,COG1943@2|Bacteria,1G5Z6@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
DTH2_k127_3185576_3	272633.26454399	2.013e-43	165.0	COG0821@1|root,COG0821@2|Bacteria,3WT3N@544448|Tenericutes	544448|Tenericutes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
DTH2_k127_3185576_1	521674.Plim_0943	3.947e-61	225.0	COG0763@1|root,COG0763@2|Bacteria,2IXXN@203682|Planctomycetes	203682|Planctomycetes	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
DTH2_k127_3185576_4	522306.CAP2UW1_4074	1.97e-08	57.0	COG2331@1|root,COG2331@2|Bacteria,1PVEY@1224|Proteobacteria,2VYJG@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
DTH2_k127_3185576_2	756272.Plabr_1542	1.053e-55	198.0	COG0590@1|root,COG0590@2|Bacteria,2IZCA@203682|Planctomycetes	203682|Planctomycetes	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
DTH2_k127_3185576_0	926692.AZYG01000034_gene2428	4.67e-86	297.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WAKZ@53433|Halanaerobiales	186801|Clostridia	S	TIGRFAM competence damage-inducible protein CinA	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
DTH2_k127_3201824_0	338963.Pcar_0609	4.817e-94	312.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria,43S5G@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
DTH2_k127_3201824_6	316067.Geob_1588	3.157e-07	54.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,42WUA@68525|delta/epsilon subdivisions,2WSM2@28221|Deltaproteobacteria,43VNW@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	ThiS family	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DTH2_k127_3201824_1	1125863.JAFN01000001_gene738	6.516e-61	217.0	COG0476@1|root,COG0476@2|Bacteria,1R87S@1224|Proteobacteria,42R16@68525|delta/epsilon subdivisions,2WNMW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.73	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	Prok-JAB,ThiF,ThiS-like
DTH2_k127_3201824_5	765420.OSCT_2222	2.195e-12	73.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	MA20_29145	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DTH2_k127_3201824_3	1218084.BBJK01000076_gene5268	1.783e-39	151.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2W2ZD@28216|Betaproteobacteria,1K75K@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Pfam Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DTH2_k127_3201824_2	316067.Geob_2779	1.226e-47	183.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria,43U15@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DTH2_k127_3201824_4	338966.Ppro_2629	1.437e-34	135.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,43TBH@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DTH2_k127_3280036_0	880073.Calab_2494	1.502e-97	327.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
DTH2_k127_3280036_1	411470.RUMGNA_02773	2.243e-54	205.0	COG1209@1|root,COG2334@1|root,COG1209@2|Bacteria,COG2334@2|Bacteria,1UXS1@1239|Firmicutes,25MC4@186801|Clostridia,3XZ7J@572511|Blautia	186801|Clostridia	M	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	APH
DTH2_k127_3280036_2	1121430.JMLG01000007_gene2573	2.741e-18	86.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,2607X@186807|Peptococcaceae	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 region	-	-	1.17.1.10,1.6.5.3	ko:K00336,ko:K05299	ko00190,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00680,map00720,map01100,map01120,map01200	M00144,M00377	R00134,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
DTH2_k127_3283017_1	243231.GSU1276	3.356e-279	869.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
DTH2_k127_3283017_0	56780.SYN_02589	0.0	1637.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
DTH2_k127_3283017_2	909663.KI867150_gene946	9.999e-162	526.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2MQXS@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
DTH2_k127_3283017_3	1191523.MROS_0711	1.253e-121	398.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
DTH2_k127_3284890_1	247490.KSU1_D0623	8.203e-148	475.0	COG0059@1|root,COG0059@2|Bacteria,2IXH2@203682|Planctomycetes	203682|Planctomycetes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
DTH2_k127_3284890_2	1121918.ARWE01000001_gene2515	1.534e-78	271.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,42RYA@68525|delta/epsilon subdivisions,2WNM0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
DTH2_k127_3284890_3	1121918.ARWE01000001_gene2516	1.121e-49	187.0	COG1132@1|root,COG1132@2|Bacteria,1QXPT@1224|Proteobacteria	1224|Proteobacteria	V	Pfam ABC	-	-	-	ko:K02068	-	M00211	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
DTH2_k127_3284890_0	1033810.HLPCO_000061	8.936e-181	584.0	COG1132@1|root,COG1132@2|Bacteria,2NQH2@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DTH2_k127_3325167_4	642492.Clole_1576	1.189e-42	158.0	COG1905@1|root,COG1905@2|Bacteria,1V4IR@1239|Firmicutes,25CD0@186801|Clostridia	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
DTH2_k127_3325167_0	596151.DesfrDRAFT_0986	2.44e-281	876.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2M833@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	bamH	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DTH2_k127_3325167_1	1121438.JNJA01000012_gene1570	5.435e-268	840.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1MXTC@1224|Proteobacteria,42YW5@68525|delta/epsilon subdivisions,2WUJF@28221|Deltaproteobacteria,2M82R@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3
DTH2_k127_3325167_2	1191523.MROS_0633	6.788e-156	511.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	napF	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_7,PAS
DTH2_k127_3325167_3	1121430.JMLG01000007_gene2579	3.755e-43	171.0	COG2208@1|root,COG2208@2|Bacteria,1TQUC@1239|Firmicutes,248FZ@186801|Clostridia,264RU@186807|Peptococcaceae	186801|Clostridia	KT	PFAM Sporulation stage II, protein E C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
DTH2_k127_3363364_0	243090.RB5346	2.244e-41	158.0	COG1943@1|root,COG1943@2|Bacteria,2J0GJ@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
DTH2_k127_3363364_1	1380380.JIAX01000006_gene654	1.845e-19	90.0	COG1476@1|root,COG1476@2|Bacteria,1N7BB@1224|Proteobacteria,2UGNF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DTH2_k127_3363364_2	1445613.JALM01000016_gene6112	3.779e-10	60.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,4E4DX@85010|Pseudonocardiales	201174|Actinobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
DTH2_k127_3363506_13	1123242.JH636434_gene3712	0.0003764	51.0	COG1360@1|root,COG1360@2|Bacteria,2IZFU@203682|Planctomycetes	203682|Planctomycetes	N	COG1360 Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
DTH2_k127_3363506_5	756272.Plabr_3639	2.273e-39	151.0	COG0103@1|root,COG0103@2|Bacteria,2J01J@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
DTH2_k127_3363506_4	224324.aq_1877	2.747e-46	171.0	COG0102@1|root,COG0102@2|Bacteria,2G3Z9@200783|Aquificae	200783|Aquificae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
DTH2_k127_3363506_0	411479.BACUNI_00694	3.34e-195	620.0	COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,2FPIS@200643|Bacteroidia,4AMYR@815|Bacteroidaceae	976|Bacteroidetes	G	Carbohydrate kinase, FGGY family protein	xylB_2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
DTH2_k127_3363506_11	1142394.PSMK_03380	1.872e-11	67.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
DTH2_k127_3363506_12	289376.THEYE_A1381	2.512e-08	63.0	COG0730@1|root,COG0730@2|Bacteria,3J1D0@40117|Nitrospirae	40117|Nitrospirae	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
DTH2_k127_3363506_2	1142394.PSMK_15840	4.078e-66	235.0	COG0134@1|root,COG0134@2|Bacteria,2IX3M@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
DTH2_k127_3363506_10	756272.Plabr_0645	1.904e-15	81.0	2EAFJ@1|root,334IY@2|Bacteria,2J12W@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
DTH2_k127_3363506_6	1187851.A33M_3291	7.237e-36	141.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria,3FD34@34008|Rhodovulum	28211|Alphaproteobacteria	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
DTH2_k127_3363506_9	582515.KR51_00021740	3.053e-20	99.0	296NU@1|root,2ZTXX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3363506_8	1095767.CAHD01000186_gene149	1.001e-25	111.0	COG3296@1|root,COG3296@2|Bacteria,2IQSV@201174|Actinobacteria,4F1HK@85016|Cellulomonadaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
DTH2_k127_3363506_3	1117108.PAALTS15_07024	1.391e-55	209.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H9KT@91061|Bacilli,26SC1@186822|Paenibacillaceae	91061|Bacilli	M	transferase	tagO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
DTH2_k127_3363506_1	278957.ABEA03000130_gene1696	8.3e-106	355.0	COG2805@1|root,COG2805@2|Bacteria,46S5Q@74201|Verrucomicrobia,3K79X@414999|Opitutae	2|Bacteria	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DTH2_k127_3363506_7	278957.ABEA03000130_gene1697	3.196e-30	127.0	COG0457@1|root,COG0457@2|Bacteria	278957.ABEA03000130_gene1697|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3372654_4	237368.SCABRO_00310	6.021e-58	218.0	COG2027@1|root,COG2027@2|Bacteria,2IYAC@203682|Planctomycetes	203682|Planctomycetes	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
DTH2_k127_3372654_8	237368.SCABRO_00714	6.942e-25	117.0	COG1253@1|root,COG1253@2|Bacteria,2J0AW@203682|Planctomycetes	203682|Planctomycetes	S	COG1253 Hemolysins and related	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
DTH2_k127_3372654_3	237368.SCABRO_00715	6.887e-68	247.0	COG1253@1|root,COG1253@2|Bacteria,2IYEG@203682|Planctomycetes	203682|Planctomycetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
DTH2_k127_3372654_5	756272.Plabr_0573	4.34e-36	147.0	COG4191@1|root,COG4191@2|Bacteria,2IYZD@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DTH2_k127_3372654_6	1158345.JNLL01000001_gene1272	1.118e-29	125.0	COG0237@1|root,COG0237@2|Bacteria,2G49A@200783|Aquificae	200783|Aquificae	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
DTH2_k127_3372654_0	247490.KSU1_C0414	1.808e-201	640.0	COG1158@1|root,COG1158@2|Bacteria,2IXV3@203682|Planctomycetes	203682|Planctomycetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
DTH2_k127_3372654_2	1408473.JHXO01000001_gene1962	6.678e-84	291.0	COG0667@1|root,COG0667@2|Bacteria,4PPAM@976|Bacteroidetes,2G14T@200643|Bacteroidia	976|Bacteroidetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DTH2_k127_3372654_7	1353528.DT23_18460	1.222e-29	135.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,2TTVB@28211|Alphaproteobacteria,2XP2F@285107|Thioclava	28211|Alphaproteobacteria	U	haemagglutination activity domain	-	-	-	-	-	-	-	-	-	-	-	-	ESPR,FG-GAP_2,Glug,Haemagg_act
DTH2_k127_3372654_1	237368.SCABRO_03203	1.327e-151	502.0	COG0072@1|root,COG0072@2|Bacteria,2IX0Q@203682|Planctomycetes	203682|Planctomycetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
DTH2_k127_342934_4	886293.Sinac_1631	6.822e-69	256.0	COG3064@1|root,COG3064@2|Bacteria,2IYZ5@203682|Planctomycetes	203682|Planctomycetes	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
DTH2_k127_342934_3	886293.Sinac_1633	6.205e-88	317.0	COG3386@1|root,COG3386@2|Bacteria,2J56X@203682|Planctomycetes	203682|Planctomycetes	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_342934_8	572546.Arcpr_0530	4.274e-25	112.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,246SQ@183980|Archaeoglobi	183980|Archaeoglobi	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
DTH2_k127_342934_6	1004785.AMBLS11_11820	1.995e-49	188.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S2SV@1236|Gammaproteobacteria,466PQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	VPA0371	-	-	-	-	-	-	-	-	-	-	-	Ysc84
DTH2_k127_342934_10	247490.KSU1_C0073	6.013e-08	61.0	COG1328@1|root,COG1328@2|Bacteria	2|Bacteria	F	CTP reductase activity	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
DTH2_k127_342934_7	521674.Plim_4090	2.318e-45	169.0	COG1327@1|root,COG1327@2|Bacteria,2IZQ3@203682|Planctomycetes	203682|Planctomycetes	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
DTH2_k127_342934_0	744872.Spica_1885	4.31e-158	506.0	COG0686@1|root,COG0686@2|Bacteria,2J6R2@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
DTH2_k127_342934_5	269799.Gmet_2382	1.841e-49	186.0	COG1418@1|root,COG1418@2|Bacteria,1RK7K@1224|Proteobacteria,42SRK@68525|delta/epsilon subdivisions,2WP5I@28221|Deltaproteobacteria,43UQH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Metal-dependent phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
DTH2_k127_342934_9	74547.PMT_1028	4.374e-23	102.0	COG3450@1|root,COG3450@2|Bacteria,1G7YR@1117|Cyanobacteria,1MMR6@1212|Prochloraceae	1117|Cyanobacteria	S	Alternative locus ID	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
DTH2_k127_342934_2	1396418.BATQ01000182_gene849	8.563e-101	346.0	COG0265@1|root,COG0265@2|Bacteria,46UAN@74201|Verrucomicrobia,2ITY6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
DTH2_k127_342934_1	1125863.JAFN01000001_gene2268	4.295e-107	357.0	COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,42P13@68525|delta/epsilon subdivisions,2WMM6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
DTH2_k127_3440836_1	504472.Slin_6583	9.931e-81	283.0	COG1609@1|root,COG4977@1|root,COG1609@2|Bacteria,COG4977@2|Bacteria,4NGPU@976|Bacteroidetes,47MD7@768503|Cytophagia	976|Bacteroidetes	K	Transcriptional regulator, AraC family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,Peripla_BP_3
DTH2_k127_3440836_2	794903.OPIT5_02915	1.363e-31	126.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DTH2_k127_3542_6	484018.BACPLE_01688	1.017e-06	58.0	2ABPK@1|root,3115K@2|Bacteria,4PA69@976|Bacteroidetes,2FW7E@200643|Bacteroidia	976|Bacteroidetes	S	Carbohydrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9
DTH2_k127_3542_1	1046714.AMRX01000008_gene867	2.138e-149	497.0	COG3345@1|root,COG3345@2|Bacteria,1NT58@1224|Proteobacteria,1SM9F@1236|Gammaproteobacteria,469CT@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Raffinose synthase or seed imbibition protein Sip1	-	-	-	-	-	-	-	-	-	-	-	-	Raffinose_syn
DTH2_k127_3542_4	460265.Mnod_5003	1.481e-39	151.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,1JZK8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
DTH2_k127_3542_5	1280390.CBQR020000110_gene2929	1.763e-36	160.0	COG2730@1|root,COG3507@1|root,COG4733@1|root,COG2730@2|Bacteria,COG3507@2|Bacteria,COG4733@2|Bacteria,1TUDC@1239|Firmicutes,4IPQ2@91061|Bacilli,26S81@186822|Paenibacillaceae	91061|Bacilli	G	Endoglucanase	celN	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Cellulase,F5_F8_type_C,RicinB_lectin_2,fn3
DTH2_k127_3542_2	330214.NIDE0756	4.837e-106	361.0	COG0769@1|root,COG0769@2|Bacteria,3J0DS@40117|Nitrospirae	40117|Nitrospirae	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DTH2_k127_3542_3	1500890.JQNL01000001_gene2980	1.99e-58	222.0	COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,1RZBM@1236|Gammaproteobacteria,1X4YD@135614|Xanthomonadales	135614|Xanthomonadales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
DTH2_k127_3542_0	1168034.FH5T_08080	6.258e-178	563.0	COG3410@1|root,COG3410@2|Bacteria,4NGT9@976|Bacteroidetes,2FRFR@200643|Bacteroidia	976|Bacteroidetes	S	Uncharacterized conserved protein (DUF2075)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2075
DTH2_k127_3561253_3	945713.IALB_2932	5.328e-22	112.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Thioredoxin_8
DTH2_k127_3561253_2	338966.Ppro_0018	6.462e-38	153.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,43SF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
DTH2_k127_3561253_4	1123371.ATXH01000006_gene820	1.397e-06	56.0	2A72X@1|root,30VYF@2|Bacteria,2GIPS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
DTH2_k127_3561253_0	886293.Sinac_6245	4.252e-137	453.0	COG1052@1|root,COG1052@2|Bacteria,2J557@203682|Planctomycetes	203682|Planctomycetes	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
DTH2_k127_3561253_1	237368.SCABRO_03724	3.981e-135	442.0	COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
DTH2_k127_3599985_3	1304880.JAGB01000001_gene542	3.19e-67	242.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_3599985_0	1121346.KB899822_gene2885	9.554e-276	864.0	COG3170@1|root,COG3170@2|Bacteria,1TT0E@1239|Firmicutes,4HA9G@91061|Bacilli,26QW2@186822|Paenibacillaceae	91061|Bacilli	NU	Beta-xylosidase	-	-	3.2.1.37	ko:K22268	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH52	-	Glyco_hydro_52
DTH2_k127_3599985_1	935948.KE386494_gene320	1.96e-159	509.0	COG0407@1|root,COG0407@2|Bacteria,1UZSW@1239|Firmicutes,24E13@186801|Clostridia,42IBM@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_3599985_2	794903.OPIT5_10915	4.681e-92	320.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DTH2_k127_3609381_1	756272.Plabr_4052	6.816e-49	179.0	COG1530@1|root,COG1530@2|Bacteria,2IWSS@203682|Planctomycetes	203682|Planctomycetes	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
DTH2_k127_3609381_3	1121423.JONT01000001_gene1931	1.515e-12	76.0	COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia,261TK@186807|Peptococcaceae	186801|Clostridia	S	protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
DTH2_k127_3609381_0	243090.RB8591	7.584e-158	516.0	COG1080@1|root,COG1080@2|Bacteria,2IX08@203682|Planctomycetes	203682|Planctomycetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr
DTH2_k127_3609381_4	867845.KI911784_gene569	4.643e-12	70.0	COG1080@1|root,COG1080@2|Bacteria,2G806@200795|Chloroflexi,376IB@32061|Chloroflexia	32061|Chloroflexia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2
DTH2_k127_3609381_2	756272.Plabr_4714	2.335e-32	131.0	COG1762@1|root,COG1762@2|Bacteria,2IZ73@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
DTH2_k127_3609381_5	1121121.KB894284_gene598	9.457e-12	70.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,4HFX9@91061|Bacilli,26R9J@186822|Paenibacillaceae	91061|Bacilli	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
DTH2_k127_3645825_1	1173022.Cri9333_2606	6.444e-113	375.0	COG1454@1|root,COG1454@2|Bacteria,1G26Q@1117|Cyanobacteria,1HAH9@1150|Oscillatoriales	1117|Cyanobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
DTH2_k127_3645825_3	96561.Dole_2279	7.994e-35	141.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2MM4X@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM toluene tolerance	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
DTH2_k127_3645825_0	96561.Dole_2278	3.872e-259	823.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MMIR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
DTH2_k127_3645825_2	338966.Ppro_0559	2.223e-67	238.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM VacJ family lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
DTH2_k127_3687177_1	880073.Calab_3750	8.301e-61	215.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972,ko:K10754	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	M00289,M00295	R00382	RC00005	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
DTH2_k127_3687177_0	644282.Deba_2027	3.655e-120	394.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
DTH2_k127_3687177_2	247490.KSU1_B0617	2.268e-54	204.0	COG1354@1|root,COG1354@2|Bacteria,2IZIR@203682|Planctomycetes	203682|Planctomycetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
DTH2_k127_3687177_5	298654.FraEuI1c_6628	3.538e-06	57.0	COG3509@1|root,COG3509@2|Bacteria,2GNV6@201174|Actinobacteria	201174|Actinobacteria	Q	Poly(3-hydroxybutyrate) depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
DTH2_k127_3687177_3	344747.PM8797T_29778	1.855e-42	157.0	COG0393@1|root,COG0393@2|Bacteria,2J0RP@203682|Planctomycetes	203682|Planctomycetes	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
DTH2_k127_3687177_4	44056.XP_009042249.1	1.503e-09	59.0	COG0790@1|root,KOG1550@2759|Eukaryota	2759|Eukaryota	T	ERAD pathway	-	-	-	ko:K07126,ko:K14026	ko04141,map04141	M00403	-	-	ko00000,ko00001,ko00002	-	-	-	Sel1
DTH2_k127_3692780_4	247490.KSU1_D0830	1.114e-49	183.0	COG0046@1|root,COG0046@2|Bacteria,2IXRT@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
DTH2_k127_3692780_1	237368.SCABRO_03866	7.055e-87	294.0	COG0047@1|root,COG0047@2|Bacteria,2IYT2@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
DTH2_k127_3692780_3	1304880.JAGB01000003_gene1255	3.069e-50	190.0	COG0407@1|root,COG0407@2|Bacteria,1V3M9@1239|Firmicutes,25AY7@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH2_k127_3692780_2	665950.HMPREF1025_02454	1.364e-62	228.0	COG1879@1|root,COG1879@2|Bacteria,1VTWD@1239|Firmicutes,24YC2@186801|Clostridia,27UBG@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_4
DTH2_k127_3692780_0	886293.Sinac_0918	8.201e-133	439.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal
DTH2_k127_3692780_6	1120977.JHUX01000004_gene2189	1.58e-27	113.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,3NNY1@468|Moraxellaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
DTH2_k127_3692780_8	679935.Alfi_0328	4.655e-13	79.0	COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,2FPK9@200643|Bacteroidia,22UF5@171550|Rikenellaceae	976|Bacteroidetes	Q	virulence factor Mce family protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
DTH2_k127_3692780_9	743719.PaelaDRAFT_0783	1.625e-06	53.0	COG0789@1|root,COG0789@2|Bacteria,1UWBI@1239|Firmicutes,4I2Z8@91061|Bacilli,26YVR@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
DTH2_k127_3692780_7	1123242.JH636434_gene4241	2.927e-15	80.0	COG0594@1|root,COG0594@2|Bacteria,2J0QW@203682|Planctomycetes	203682|Planctomycetes	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
DTH2_k127_3692780_5	1265507.KB899636_gene1504	6.285e-28	125.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQMI@1236|Gammaproteobacteria,1Y3XT@135624|Aeromonadales	135624|Aeromonadales	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12278	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
DTH2_k127_3692780_10	1307761.L21SP2_3408	1.554e-05	50.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.202,2.7.13.3	ko:K02768,ko:K02769,ko:K02770,ko:K02806,ko:K07646	ko00051,ko01100,ko01120,ko02020,ko02060,map00051,map01100,map01120,map02020,map02060	M00273,M00454	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022	4.A.2.1	-	-	KdpD,Na_H_Exchanger,PTS_EIIA_2
DTH2_k127_3697488_1	706587.Desti_1810	2.274e-17	90.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
DTH2_k127_3697488_0	96561.Dole_2003	1.75e-122	402.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MIPS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
DTH2_k127_3701366_2	316067.Geob_1365	1.246e-14	85.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,43U7R@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methionine synthase B12-binding module cap domain protein	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
DTH2_k127_3701366_1	1205680.CAKO01000030_gene4914	2.717e-32	131.0	COG0537@1|root,COG0537@2|Bacteria,1N422@1224|Proteobacteria,2VA77@28211|Alphaproteobacteria,2JYEN@204441|Rhodospirillales	204441|Rhodospirillales	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	-	-	-	-	-	-	-	-	-	HIT
DTH2_k127_3701366_0	1168067.JAGP01000001_gene2185	1.621e-57	207.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,45ZUW@72273|Thiotrichales	72273|Thiotrichales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
DTH2_k127_3714810_1	639282.DEFDS_1643	6.4e-45	171.0	COG0500@1|root,COG2226@2|Bacteria,2GFAY@200930|Deferribacteres	200930|Deferribacteres	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
DTH2_k127_3714810_3	675816.VIA_002736	0.0001107	49.0	2APBA@1|root,31EDH@2|Bacteria,1RIDJ@1224|Proteobacteria,1S6VZ@1236|Gammaproteobacteria,1XXQ8@135623|Vibrionales	135623|Vibrionales	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
DTH2_k127_3714810_2	338963.Pcar_2756	3.599e-23	101.0	2E5UQ@1|root,330IY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3714810_0	1265505.ATUG01000001_gene3161	8.876e-49	179.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,43AFQ@68525|delta/epsilon subdivisions,2X5VI@28221|Deltaproteobacteria,2MJRP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
DTH2_k127_3825472_3	1121382.JQKG01000023_gene1514	9.831e-54	194.0	COG0066@1|root,COG0066@2|Bacteria,1WIV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
DTH2_k127_3825472_0	289376.THEYE_A0114	3.272e-156	499.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH2_k127_3825472_2	1117647.M5M_16595	2.704e-122	409.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1JAKV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG2211 Na melibiose symporter and related transporters	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
DTH2_k127_3825472_1	283942.IL1999	7.762e-129	415.0	COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,1RP49@1236|Gammaproteobacteria,2QFJ4@267893|Idiomarinaceae	1236|Gammaproteobacteria	E	Saccharopine dehydrogenase	HA62_29220	-	1.5.1.43,1.5.1.7	ko:K00290,ko:K13746	ko00300,ko00310,ko00330,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00330,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R09079,R09080	RC00053,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
DTH2_k127_3838042_0	153948.NAL212_2588	3.013e-238	739.0	COG0446@1|root,COG3453@1|root,COG0446@2|Bacteria,COG3453@2|Bacteria,1N5MC@1224|Proteobacteria,2VKI2@28216|Betaproteobacteria,3726A@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DUF442,Pyr_redox_2
DTH2_k127_3838042_1	153948.NAL212_2587	3.637e-70	242.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,2VQ23@28216|Betaproteobacteria,37327@32003|Nitrosomonadales	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
DTH2_k127_3839668_1	521674.Plim_2636	9.984e-143	467.0	COG3250@1|root,COG3250@2|Bacteria,2J54D@203682|Planctomycetes	203682|Planctomycetes	G	Pfam:DUF303	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	SASA
DTH2_k127_3839668_3	313612.L8106_12095	1.55e-71	250.0	COG1051@1|root,COG1051@2|Bacteria,1G4H7@1117|Cyanobacteria,1HEY6@1150|Oscillatoriales	1117|Cyanobacteria	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
DTH2_k127_3839668_0	1379270.AUXF01000004_gene3330	9.934e-191	614.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
DTH2_k127_3839668_4	521011.Mpal_1762	6.206e-46	169.0	arCOG08226@1|root,arCOG08226@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3839668_5	1411123.JQNH01000001_gene2315	6.388e-09	61.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
DTH2_k127_3839668_2	935845.JADQ01000014_gene3467	1.601e-98	337.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,4HAN2@91061|Bacilli,26QBK@186822|Paenibacillaceae	91061|Bacilli	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
DTH2_k127_3845759_5	1337093.MBE-LCI_0091	3.296e-07	62.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,2P896@245186|Loktanella	28211|Alphaproteobacteria	M	MacB-like periplasmic core domain	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
DTH2_k127_3845759_4	1121406.JAEX01000014_gene2339	4.62e-14	85.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2M7ZM@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
DTH2_k127_3845759_2	247490.KSU1_D0648	4.62e-72	249.0	COG1136@1|root,COG1136@2|Bacteria,2IYZ3@203682|Planctomycetes	203682|Planctomycetes	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
DTH2_k127_3845759_0	247490.KSU1_D0649	7.077e-107	353.0	COG0115@1|root,COG0115@2|Bacteria,2IY3N@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
DTH2_k127_3845759_3	886293.Sinac_2664	7.049e-61	223.0	COG0142@1|root,COG0142@2|Bacteria,2IXUE@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
DTH2_k127_3845759_1	880073.Calab_0173	2.859e-79	270.0	COG0551@1|root,COG0551@2|Bacteria,2NQZQ@2323|unclassified Bacteria	2|Bacteria	L	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
DTH2_k127_3848068_8	1142394.PSMK_23630	1.461e-09	67.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2IYCQ@203682|Planctomycetes	203682|Planctomycetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	SecD_SecF,Sec_GG
DTH2_k127_3848068_7	1121396.KB893083_gene441	9.155e-11	68.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MKCK@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
DTH2_k127_3848068_0	521674.Plim_1347	4.031e-136	442.0	COG0343@1|root,COG0343@2|Bacteria,2IWXI@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
DTH2_k127_3848068_4	1121468.AUBR01000027_gene2877	2.016e-39	162.0	COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,24CYM@186801|Clostridia,42FS4@68295|Thermoanaerobacterales	186801|Clostridia	D	Stage II sporulation D domain protein	lytB	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	PG_binding_1,SpoIID,Y_Y_Y
DTH2_k127_3848068_2	886293.Sinac_5630	2.261e-88	307.0	COG0202@1|root,COG0457@1|root,COG0202@2|Bacteria,COG0457@2|Bacteria,2IXMK@203682|Planctomycetes	203682|Planctomycetes	K	rna polymerase alpha	-	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,TPR_1,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
DTH2_k127_3848068_6	404589.Anae109_2535	1.464e-20	104.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,42UC6@68525|delta/epsilon subdivisions,2WPDD@28221|Deltaproteobacteria,2YVEN@29|Myxococcales	28221|Deltaproteobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
DTH2_k127_3848068_3	1121434.AULY01000006_gene815	1.22e-46	183.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,42UV6@68525|delta/epsilon subdivisions,2WP1R@28221|Deltaproteobacteria,2MAEX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM 6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
DTH2_k127_3848068_9	1396418.BATQ01000156_gene5584	1.008e-05	56.0	2EGCD@1|root,33A46@2|Bacteria,46Z2P@74201|Verrucomicrobia,2IWC7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190,DUF4339
DTH2_k127_3848068_5	1121324.CLIT_20c00470	2.183e-37	147.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,25TZ8@186804|Peptostreptococcaceae	186801|Clostridia	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	cobO	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
DTH2_k127_3848068_1	574087.Acear_2112	5.516e-126	413.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
DTH2_k127_3859878_2	1535422.ND16A_2704	3.077e-10	72.0	COG1664@1|root,COG4726@1|root,COG1664@2|Bacteria,COG4726@2|Bacteria,1R7GS@1224|Proteobacteria,1RS5Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
DTH2_k127_3859878_3	452637.Oter_0650	1.672e-09	70.0	COG4726@1|root,COG4726@2|Bacteria,46YMK@74201|Verrucomicrobia,3K9UG@414999|Opitutae	414999|Opitutae	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3859878_1	1379698.RBG1_1C00001G1258	1.919e-15	88.0	COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria	2|Bacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
DTH2_k127_3859878_0	626523.GCWU000342_01596	4.513e-67	237.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
DTH2_k127_3882194_2	1121468.AUBR01000107_gene3114	4.224e-10	61.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,42EYH@68295|Thermoanaerobacterales	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
DTH2_k127_3882194_0	498761.HM1_0103	2.371e-129	422.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DTH2_k127_3882194_4	56780.SYN_01381	0.0008264	43.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
DTH2_k127_3882194_3	400682.PAC_15715938	7.044e-08	56.0	COG1063@1|root,KOG0024@2759|Eukaryota,38BYX@33154|Opisthokonta,3B9JA@33208|Metazoa	33208|Metazoa	Q	L-iditol 2-dehydrogenase activity	-	GO:0008150,GO:0030431,GO:0032501	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH2_k127_3882194_1	1321815.HMPREF9193_00614	5.542e-38	154.0	COG1609@1|root,COG1609@2|Bacteria,2J7EG@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
DTH2_k127_3882632_1	637905.SVI_3047	9.571e-09	67.0	28MJ4@1|root,2ZAVQ@2|Bacteria,1R62K@1224|Proteobacteria,1RNQC@1236|Gammaproteobacteria,2QADS@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	VP2126	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3882632_0	344747.PM8797T_25511	2.708e-62	233.0	COG0544@1|root,COG0544@2|Bacteria,2IXGD@203682|Planctomycetes	203682|Planctomycetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
DTH2_k127_3923_2	1159870.KB907784_gene2535	4.26e-08	57.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,3T390@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
DTH2_k127_3923_0	706587.Desti_2763	1.068e-268	838.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MR3P@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	PFAM Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
DTH2_k127_3933836_2	1121445.ATUZ01000011_gene559	1.257e-97	326.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MGE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
DTH2_k127_3933836_1	909663.KI867150_gene1425	1.072e-98	326.0	COG4232@1|root,COG4232@2|Bacteria,1PK9S@1224|Proteobacteria,42PV0@68525|delta/epsilon subdivisions,2WJPK@28221|Deltaproteobacteria,2MS43@213462|Syntrophobacterales	28221|Deltaproteobacteria	CO	PFAM cytochrome c biogenesis protein, transmembrane region	dsbD	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
DTH2_k127_3933836_0	1047013.AQSP01000092_gene323	1.928e-197	621.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
DTH2_k127_394118_3	489653.NLA_2190	2.513e-13	81.0	2F53X@1|root,33XR3@2|Bacteria,1NVPM@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_394118_2	926569.ANT_31570	1.118e-41	167.0	COG2199@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,2G8CK@200795|Chloroflexi	200795|Chloroflexi	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
DTH2_k127_394118_4	1122927.KB895412_gene714	4.199e-08	57.0	COG0789@1|root,COG0789@2|Bacteria,1V9SJ@1239|Firmicutes,4HJR2@91061|Bacilli,26X68@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
DTH2_k127_394118_1	1449126.JQKL01000001_gene1348	2.289e-65	233.0	COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,24AIN@186801|Clostridia,26B2D@186813|unclassified Clostridiales	186801|Clostridia	D	Cellulose biosynthesis protein BcsQ	flhG	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
DTH2_k127_394118_0	1142394.PSMK_22790	8.519e-89	301.0	COG1191@1|root,COG1191@2|Bacteria,2IX9S@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
DTH2_k127_3964174_0	1142394.PSMK_14290	3.708e-84	286.0	COG0639@1|root,COG0639@2|Bacteria,2IYH6@203682|Planctomycetes	203682|Planctomycetes	T	COG0639 Diadenosine tetraphosphatase and related	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
DTH2_k127_3964174_3	1123320.KB889709_gene8421	2.763e-18	93.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
DTH2_k127_3964174_1	237368.SCABRO_03451	1.054e-52	196.0	COG0115@1|root,COG0115@2|Bacteria,2J20K@203682|Planctomycetes	203682|Planctomycetes	EH	Amino-transferase class IV	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_4
DTH2_k127_3964174_2	862515.HMPREF0658_2100	2.698e-31	127.0	COG2250@1|root,COG2250@2|Bacteria,4NYJS@976|Bacteroidetes,2FS8A@200643|Bacteroidia	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
DTH2_k127_3964174_4	562970.Btus_1153	5.386e-08	58.0	COG1708@1|root,COG1708@2|Bacteria,1VQT3@1239|Firmicutes	1239|Firmicutes	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
DTH2_k127_4036453_3	1232410.KI421415_gene3076	5.584e-50	185.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
DTH2_k127_4036453_1	1125863.JAFN01000001_gene2405	1.118e-92	315.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2495	GATase,Glycos_trans_3N,Glycos_transf_3
DTH2_k127_4036453_2	1095749.HMPREF1052_0097	2.296e-59	211.0	COG0512@1|root,COG0512@2|Bacteria,1RAKJ@1224|Proteobacteria,1RREB@1236|Gammaproteobacteria,1Y7E2@135625|Pasteurellales	135625|Pasteurellales	EH	Anthranilate synthase	trpG	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DTH2_k127_4036453_0	1117318.PRUB_14746	1.105e-100	344.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,2PZY2@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	E	COG0147 Anthranilate para-aminobenzoate synthases component I	trpE	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_1603	Anth_synt_I_N,Chorismate_bind
DTH2_k127_4058577_1	717605.Theco_2601	8.573e-104	350.0	COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,4HC0B@91061|Bacilli,26U8T@186822|Paenibacillaceae	91061|Bacilli	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DTH2_k127_4058577_2	903814.ELI_0428	2.434e-43	174.0	COG1063@1|root,COG1063@2|Bacteria,1TQ60@1239|Firmicutes,248JR@186801|Clostridia,25VQE@186806|Eubacteriaceae	186801|Clostridia	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH2_k127_4058577_0	1121904.ARBP01000017_gene5099	1.72e-142	460.0	COG2017@1|root,COG2017@2|Bacteria,4NHQH@976|Bacteroidetes,47JMF@768503|Cytophagia	976|Bacteroidetes	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
DTH2_k127_4058577_3	926550.CLDAP_32200	1.017e-14	76.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
DTH2_k127_4058624_0	269799.Gmet_3159	4.387e-303	952.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
DTH2_k127_4058624_1	264198.Reut_B3749	3.302e-121	405.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,1K1D4@119060|Burkholderiaceae	28216|Betaproteobacteria	J	promotes GTP-dependent translocation of the ribosome during translation	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
DTH2_k127_4103578_0	204669.Acid345_4075	6.871e-125	406.0	COG2326@1|root,COG2326@2|Bacteria,3Y5E4@57723|Acidobacteria,2JMFN@204432|Acidobacteriia	204432|Acidobacteriia	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
DTH2_k127_4103578_1	1211579.PP4_25170	1.254e-07	61.0	2DN52@1|root,32VJD@2|Bacteria,1N1NP@1224|Proteobacteria,1T64Y@1236|Gammaproteobacteria,1YY80@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
DTH2_k127_410936_1	243090.RB8909	2.093e-95	319.0	COG1283@1|root,COG1283@2|Bacteria,2J2H6@203682|Planctomycetes	203682|Planctomycetes	P	COG1283 Na phosphate symporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
DTH2_k127_410936_4	237368.SCABRO_01122	1.388e-72	250.0	COG0704@1|root,COG0704@2|Bacteria,2IYX4@203682|Planctomycetes	203682|Planctomycetes	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DTH2_k127_410936_2	340177.Cag_0498	1.402e-88	299.0	COG1117@1|root,COG1117@2|Bacteria,1FEHB@1090|Chlorobi	1090|Chlorobi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DTH2_k127_410936_3	246194.CHY_2116	2.004e-85	292.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,42F1M@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DTH2_k127_410936_0	1408422.JHYF01000006_gene1212	1.904e-101	343.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,36DCX@31979|Clostridiaceae	186801|Clostridia	P	Phosphate transport system permease protein PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
DTH2_k127_410936_5	498761.HM1_2083	2.163e-69	241.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DTH2_k127_4109656_0	1232410.KI421416_gene2649	8.059e-236	745.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2WK5T@28221|Deltaproteobacteria,43TCV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	aplA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
DTH2_k127_4109656_1	1121396.KB893012_gene4099	1.565e-21	98.0	COG3162@1|root,COG3162@2|Bacteria,1NB5T@1224|Proteobacteria,42VP8@68525|delta/epsilon subdivisions,2WSCP@28221|Deltaproteobacteria,2MNWK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
DTH2_k127_4122455_3	1116375.VEJY3_20786	6.764e-08	59.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0044237,GO:0044249	2.1.1.254,2.1.1.295,2.1.1.79,2.7.11.1	ko:K00574,ko:K07154,ko:K14369,ko:K15257,ko:K18534	ko00130,ko00522,ko01100,ko01110,ko01130,map00130,map00522,map01100,map01110,map01130	M00112,M00774	R05520,R05532,R07501,R10709,R10710	RC00003,RC01324,RC01662	ko00000,ko00001,ko00002,ko01000,ko01001,ko01008,ko02048,ko03016	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
DTH2_k127_4122455_4	1033738.CAEP01000052_gene2763	2.557e-05	46.0	COG0454@1|root,COG0456@2|Bacteria,1V64S@1239|Firmicutes,4HH30@91061|Bacilli,26HKD@186818|Planococcaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DTH2_k127_4122455_1	1499967.BAYZ01000167_gene6735	1.33e-44	166.0	COG0454@1|root,COG0456@2|Bacteria,2NS1J@2323|unclassified Bacteria	2|Bacteria	K	FR47-like protein	argO	-	2.3.1.1	ko:K03826,ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
DTH2_k127_4122455_2	1123242.JH636434_gene3372	4.711e-44	164.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DTH2_k127_4122455_0	497964.CfE428DRAFT_0913	9.317e-72	258.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DTH2_k127_4127594_0	1121104.AQXH01000001_gene1426	3.708e-317	986.0	COG0495@1|root,COG0495@2|Bacteria,4NE5K@976|Bacteroidetes,1IP89@117747|Sphingobacteriia	976|Bacteroidetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,DUF559,tRNA-synt_1,tRNA-synt_1_2
DTH2_k127_4127594_9	56780.SYN_03008	2.291e-35	139.0	COG1959@1|root,COG1959@2|Bacteria,1PC6N@1224|Proteobacteria,43EVM@68525|delta/epsilon subdivisions,2X9SC@28221|Deltaproteobacteria,2MSFF@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DTH2_k127_4127594_11	234267.Acid_5891	4.472e-15	77.0	COG3205@1|root,COG3205@2|Bacteria	2|Bacteria	P	membrane	-	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2061
DTH2_k127_4127594_7	1408473.JHXO01000013_gene531	1.188e-89	301.0	COG0175@1|root,COG0175@2|Bacteria,4NGVI@976|Bacteroidetes,2FPGR@200643|Bacteroidia	976|Bacteroidetes	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
DTH2_k127_4127594_3	203119.Cthe_2536	6.235e-158	501.0	COG0175@1|root,COG0175@2|Bacteria,1U1VN@1239|Firmicutes,248Y9@186801|Clostridia,3WJJK@541000|Ruminococcaceae	186801|Clostridia	EH	PFAM Phosphoadenosine phosphosulfate reductase	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
DTH2_k127_4127594_2	203119.Cthe_2537	5.252e-205	654.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1TQXK@1239|Firmicutes,25EK3@186801|Clostridia,3WISI@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D3
DTH2_k127_4127594_8	509635.N824_02445	2.146e-42	172.0	COG0155@1|root,COG0155@2|Bacteria,4NENW@976|Bacteroidetes,1INY4@117747|Sphingobacteriia	976|Bacteroidetes	C	Nitrite and sulphite reductase 4Fe-4S	-	-	1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	HEPN,NIR_SIR,NIR_SIR_ferr,TusA
DTH2_k127_4127594_1	1499967.BAYZ01000079_gene883	2.411e-231	721.0	COG2873@1|root,COG2873@2|Bacteria,2NQN4@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DTH2_k127_4127594_14	1329516.JPST01000003_gene1222	3.167e-05	49.0	COG5583@1|root,COG5583@2|Bacteria,1VMPP@1239|Firmicutes,4HRBK@91061|Bacilli	91061|Bacilli	S	Uncharacterized small protein (DUF2292)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2292
DTH2_k127_4127594_12	228405.HNE_2582	3.847e-14	83.0	28JGK@1|root,2Z9AA@2|Bacteria,1MWFY@1224|Proteobacteria,2U3RX@28211|Alphaproteobacteria,43YZY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3034)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3034
DTH2_k127_4127594_5	1120972.AUMH01000004_gene1385	2.698e-132	428.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,279A5@186823|Alicyclobacillaceae	91061|Bacilli	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK5	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH2_k127_4127594_4	1379698.RBG1_1C00001G1697	2.446e-144	466.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metC	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
DTH2_k127_4127594_10	886293.Sinac_6668	3.75e-20	93.0	COG0476@1|root,COG0476@2|Bacteria,2IWVB@203682|Planctomycetes	203682|Planctomycetes	H	involved in molybdopterin and thiamine biosynthesis family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
DTH2_k127_4127594_13	1123242.JH636434_gene5342	4.963e-14	77.0	2DSSH@1|root,33H9S@2|Bacteria,2J1GW@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase Ligase (LigD)	-	-	-	-	-	-	-	-	-	-	-	-	LigD_N
DTH2_k127_4127594_6	1206733.BAGC01000064_gene3272	6.287e-91	309.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,2GJ5U@201174|Actinobacteria,4FX76@85025|Nocardiaceae	201174|Actinobacteria	C	belongs to the CobB CobQ family	pta	GO:0005575,GO:0005576	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
DTH2_k127_4142813_3	247490.KSU1_C0310	1.602e-08	57.0	COG3880@1|root,COG3880@2|Bacteria,2J09E@203682|Planctomycetes	203682|Planctomycetes	S	protein with conserved CXXC pairs	-	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
DTH2_k127_4142813_0	1142394.PSMK_26160	9.37e-104	348.0	COG3869@1|root,COG3869@2|Bacteria,2IXJG@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
DTH2_k127_4142813_1	1121451.DESAM_20489	3.046e-39	153.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,42TIP@68525|delta/epsilon subdivisions,2X5J4@28221|Deltaproteobacteria,2MGRS@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
DTH2_k127_4142813_2	857293.CAAU_2467	2.14e-30	128.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,36I28@31979|Clostridiaceae	186801|Clostridia	L	RNA methyltransferase, RsmD family	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
DTH2_k127_4148211_5	575540.Isop_3388	7.296e-17	86.0	COG0612@1|root,COG0612@2|Bacteria,2IY7Q@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DTH2_k127_4148211_0	237368.SCABRO_03338	1.042e-194	650.0	COG1196@1|root,COG1196@2|Bacteria,2IY32@203682|Planctomycetes	203682|Planctomycetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DTH2_k127_4148211_7	880073.Calab_2664	2.313e-09	70.0	COG1706@1|root,COG1706@2|Bacteria,2NQI7@2323|unclassified Bacteria	2|Bacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
DTH2_k127_4148211_1	997884.HMPREF1068_01634	1.495e-180	574.0	COG1626@1|root,COG1626@2|Bacteria,4PC3G@976|Bacteroidetes,2FQQD@200643|Bacteroidia,4ANEP@815|Bacteroidaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 63 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
DTH2_k127_4148211_8	529709.PYCH_06300	0.0003433	53.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,242U5@183968|Thermococci	183968|Thermococci	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
DTH2_k127_4148211_4	1168289.AJKI01000040_gene3174	1.827e-44	177.0	2DYE6@1|root,349BE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4148211_6	268407.PWYN_26920	1.886e-11	76.0	COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,4H9P9@91061|Bacilli,26T8S@186822|Paenibacillaceae	91061|Bacilli	O	serine protease	yqeZ	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
DTH2_k127_4148211_2	237368.SCABRO_01725	3.468e-129	423.0	COG3635@1|root,COG3635@2|Bacteria,2IXCZ@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
DTH2_k127_4148211_3	665571.STHERM_c01940	1.298e-121	404.0	COG0460@1|root,COG0460@2|Bacteria,2J89J@203691|Spirochaetes	203691|Spirochaetes	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
DTH2_k127_4150784_2	1127673.GLIP_0524	2.653e-06	55.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria,468KR@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG4969 Tfp pilus assembly protein, major pilin PilA	ppdD	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464	-	ko:K02650,ko:K02682	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
DTH2_k127_4150784_1	1254432.SCE1572_37530	1.137e-65	240.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2YU38@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DTH2_k127_4150784_0	247490.KSU1_C1383	8.485e-176	562.0	COG2183@1|root,COG2183@2|Bacteria,2IY4J@203682|Planctomycetes	203682|Planctomycetes	K	S1, RNA binding domain	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
DTH2_k127_4150999_2	768710.DesyoDRAFT_3377	1.053e-27	121.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
DTH2_k127_4150999_3	649747.HMPREF0083_05109	1.897e-18	92.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,26TDT@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DTH2_k127_4150999_1	760011.Spico_1036	4.324e-67	230.0	COG0432@1|root,COG0432@2|Bacteria,2J7PN@203691|Spirochaetes	203691|Spirochaetes	S	Secondary thiamine-phosphate synthase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
DTH2_k127_4150999_0	1121440.AUMA01000016_gene193	1.643e-80	274.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,43ADI@68525|delta/epsilon subdivisions,2WPU6@28221|Deltaproteobacteria,2MB6H@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
DTH2_k127_4172656_2	1051501.AYTL01000030_gene2439	3.431e-07	52.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,1ZFJ7@1386|Bacillus	91061|Bacilli	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
DTH2_k127_4172656_0	1142394.PSMK_04800	1.263e-43	169.0	COG1360@1|root,COG1360@2|Bacteria,2J1IS@203682|Planctomycetes	203682|Planctomycetes	N	Flagellar motor protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
DTH2_k127_4178401_2	290512.Paes_0944	6.832e-65	227.0	COG0573@1|root,COG0573@2|Bacteria,1FE1M@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstC	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DTH2_k127_4178401_1	290512.Paes_0945	1.408e-95	333.0	COG0581@1|root,COG0581@2|Bacteria,1FE3G@1090|Chlorobi	1090|Chlorobi	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DTH2_k127_4178401_0	1278304.JAFR01000013_gene684	1.142e-103	344.0	COG1117@1|root,COG1117@2|Bacteria,3WSY5@544448|Tenericutes	544448|Tenericutes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DTH2_k127_4178401_3	1232410.KI421421_gene3398	1.884e-62	221.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,43SH1@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	PhoU domain	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DTH2_k127_4178401_4	1403819.BATR01000100_gene3320	1.867e-08	63.0	COG2911@1|root,COG3210@1|root,COG4625@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,46UDW@74201|Verrucomicrobia,2IW5P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Passenger-associated-transport-repeat	-	-	-	-	-	-	-	-	-	-	-	-	PATR
DTH2_k127_4189303_2	247490.KSU1_C0165	4.463e-117	392.0	COG1032@1|root,COG1032@2|Bacteria,2IXAT@203682|Planctomycetes	203682|Planctomycetes	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH2_k127_4189303_1	748449.Halha_0432	4.537e-129	436.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3WA67@53433|Halanaerobiales	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DTH2_k127_4189303_4	1304885.AUEY01000017_gene3732	1.071e-16	85.0	2DN2Z@1|root,32V89@2|Bacteria,1N3VG@1224|Proteobacteria,42TI7@68525|delta/epsilon subdivisions,2WQNX@28221|Deltaproteobacteria,2MKM9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3
DTH2_k127_4189303_5	439235.Dalk_3653	3.844e-11	70.0	COG3809@1|root,COG3809@2|Bacteria,1P0JI@1224|Proteobacteria,432XD@68525|delta/epsilon subdivisions,2WY3I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
DTH2_k127_4189303_3	1123242.JH636434_gene4168	2.764e-68	250.0	COG0144@1|root,COG0144@2|Bacteria,2J09U@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
DTH2_k127_4189303_6	459495.SPLC1_S270840	5.92e-08	63.0	COG0457@1|root,COG1215@1|root,COG1216@1|root,COG0457@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,1GQBE@1117|Cyanobacteria,1H7DT@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2,RgpF,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
DTH2_k127_4189303_0	742725.HMPREF9450_00245	3.039e-161	535.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FQU9@200643|Bacteroidia,22VEC@171550|Rikenellaceae	976|Bacteroidetes	G	Galactose mutarotase-like	-	-	3.2.1.177,3.2.1.20	ko:K01187,ko:K01811	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
DTH2_k127_4214286_3	247490.KSU1_D0541	3.719e-13	74.0	2EDD9@1|root,3379K@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3568)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3568
DTH2_k127_4214286_0	290315.Clim_0792	1.541e-196	621.0	COG1115@1|root,COG1115@2|Bacteria,1FDTJ@1090|Chlorobi	1090|Chlorobi	E	TIGRFAM amino acid carrier protein	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
DTH2_k127_4214286_1	289377.HL41_04930	2.339e-118	389.0	COG1180@1|root,COG1180@2|Bacteria,2GH8R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
DTH2_k127_4214286_2	1382306.JNIM01000001_gene1943	1.886e-24	113.0	COG2047@1|root,COG2047@2|Bacteria,2G9KI@200795|Chloroflexi	200795|Chloroflexi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
DTH2_k127_4225833_0	886293.Sinac_4788	5.666e-66	238.0	COG0352@1|root,COG0352@2|Bacteria,2IY16@203682|Planctomycetes	203682|Planctomycetes	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Clp_N,TMP-TENI
DTH2_k127_4225833_1	545697.HMPREF0216_01100	2.515e-06	53.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,36DEP@31979|Clostridiaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
DTH2_k127_4254830_3	1123508.JH636441_gene3468	2.202e-10	66.0	COG2189@1|root,COG2189@2|Bacteria,2IWRP@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DTH2_k127_4254830_1	575540.Isop_3432	5.624e-57	220.0	COG0815@1|root,COG0815@2|Bacteria,2IWUW@203682|Planctomycetes	203682|Planctomycetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
DTH2_k127_4254830_4	289376.THEYE_A2071	1.419e-08	66.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
DTH2_k127_4254830_0	1142394.PSMK_29610	3.173e-62	224.0	COG1234@1|root,COG1234@2|Bacteria,2IWSW@203682|Planctomycetes	203682|Planctomycetes	S	of the beta-lactamase	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
DTH2_k127_4254830_5	665571.STHERM_c04360	8.582e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,2J6MJ@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
DTH2_k127_4254830_2	1273103.NM10_00894	5.569e-41	158.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,4H4NK@909932|Negativicutes	909932|Negativicutes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
DTH2_k127_4268790_5	278957.ABEA03000130_gene1699	5.273e-12	68.0	2EJWH@1|root,33DM6@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2997)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2997
DTH2_k127_4268790_0	278957.ABEA03000130_gene1701	1.94e-191	612.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	ycf46	-	3.6.4.6	ko:K06027	ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962	-	-	-	ko00000,ko00001,ko01000,ko04131	1.F.1.1	-	-	AAA
DTH2_k127_4268790_3	269797.Mbar_A3602	9.64e-46	176.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,2N9U1@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S protein PflX, homolog of pyruvate formate lyase activating	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DTH2_k127_4268790_1	926549.KI421517_gene999	9.635e-180	571.0	COG2183@1|root,COG2183@2|Bacteria,4NETD@976|Bacteroidetes,47MKQ@768503|Cytophagia	976|Bacteroidetes	K	TIGRFAM competence protein ComEA helix-hairpin-helix repeat region	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
DTH2_k127_4268901_4	1123242.JH636434_gene4020	4.541e-46	178.0	COG2010@1|root,COG2010@2|Bacteria,2IZQX@203682|Planctomycetes	203682|Planctomycetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
DTH2_k127_4268901_2	485917.Phep_0757	2.658e-155	502.0	COG0477@1|root,COG2814@2|Bacteria,4NE09@976|Bacteroidetes,1IP67@117747|Sphingobacteriia	976|Bacteroidetes	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	xylE	-	-	ko:K02100,ko:K03444,ko:K08138	-	-	-	-	ko00000,ko02000	2.A.1.1,2.A.1.1.2,2.A.1.1.3	-	-	Sugar_tr
DTH2_k127_4268901_1	589865.DaAHT2_0197	5.378e-226	712.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,42PTE@68525|delta/epsilon subdivisions,2WKRZ@28221|Deltaproteobacteria,2MIH0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
DTH2_k127_4268901_0	589865.DaAHT2_0196	1.029e-282	884.0	COG2025@1|root,COG2086@1|root,COG2025@2|Bacteria,COG2086@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MIMG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
DTH2_k127_4268901_3	697281.Mahau_1084	6.282e-74	254.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
DTH2_k127_427634_4	573370.DMR_17610	3.887e-59	207.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MBEZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Desulfoferrodoxin ferrous iron-binding region	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
DTH2_k127_427634_0	1047013.AQSP01000144_gene920	1.191e-155	500.0	COG0426@1|root,COG0426@2|Bacteria,2NPHV@2323|unclassified Bacteria	2|Bacteria	C	Metallo-beta-lactamase superfamily	dfa1	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Flavodoxin_1,Lactamase_B
DTH2_k127_427634_2	398767.Glov_2959	1.467e-61	218.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,42RE8@68525|delta/epsilon subdivisions,2WNA5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Redoxin
DTH2_k127_427634_1	926561.KB900617_gene1208	6.283e-79	267.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3WC58@53433|Halanaerobiales	186801|Clostridia	C	Ferritin-like domain	rbr	GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_427634_5	1499967.BAYZ01000151_gene1660	9.378e-43	161.0	COG0735@1|root,COG0735@2|Bacteria,2NQ8Z@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the Fur family	perR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
DTH2_k127_427634_3	880073.Calab_0640	1.541e-60	213.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	SSF
DTH2_k127_4317689_1	794903.OPIT5_10195	2.838e-21	104.0	COG1874@1|root,COG3170@1|root,COG1874@2|Bacteria,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	3.1.3.3,3.2.1.23,3.5.1.28	ko:K01448,ko:K07315,ko:K12308,ko:K21000,ko:K21470	ko00052,ko01503,ko02025,map00052,map01503,map02025	M00727	R01105,R04112	RC00064,RC00141,RC00452	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03021,ko03036	-	GH39	-	Glyco_hydro_42
DTH2_k127_4317689_0	742725.HMPREF9450_01626	1.961e-60	234.0	COG1874@1|root,COG1874@2|Bacteria,4P500@976|Bacteroidetes	976|Bacteroidetes	G	Beta-galactosidase	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42
DTH2_k127_4318567_5	869213.JCM21142_3898	1e-84	283.0	COG1748@1|root,COG1748@2|Bacteria,4NE0Y@976|Bacteroidetes,47KY2@768503|Cytophagia	976|Bacteroidetes	E	PFAM Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
DTH2_k127_4318567_1	794903.OPIT5_02915	5.036e-163	535.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DTH2_k127_4318567_2	927658.AJUM01000034_gene575	2.097e-136	448.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
DTH2_k127_4318567_3	385682.AFSL01000069_gene1490	1.05e-135	441.0	COG0667@1|root,COG0667@2|Bacteria,4NFCN@976|Bacteroidetes,2FMAG@200643|Bacteroidia,3XIRM@558415|Marinilabiliaceae	976|Bacteroidetes	C	Aldo/keto reductase family	gpr	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
DTH2_k127_4318567_7	237368.SCABRO_04014	2.765e-14	75.0	COG1826@1|root,COG1826@2|Bacteria,2J1B7@203682|Planctomycetes	203682|Planctomycetes	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
DTH2_k127_4318567_6	1121439.dsat_1040	1.15e-36	149.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2M9RT@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
DTH2_k127_4318567_0	1349822.NSB1T_02555	3.217e-171	547.0	2DCM8@1|root,2ZEKS@2|Bacteria,4P835@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4318567_4	472759.Nhal_1884	1.595e-133	430.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WZYK@135613|Chromatiales	135613|Chromatiales	H	Belongs to the RtcB family	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
DTH2_k127_436901_1	1242864.D187_010369	5.182e-20	103.0	COG1572@1|root,COG1572@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria,2YYU3@29|Myxococcales	28221|Deltaproteobacteria	S	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR,Kelch_4,PQQ_2,VCBS
DTH2_k127_436901_0	1492737.FEM08_22460	2.429e-38	156.0	COG5295@1|root,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia,2NX0A@237|Flavobacterium	976|Bacteroidetes	UW	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,YadA_head
DTH2_k127_4411210_1	349163.Acry_1030	1.062e-41	160.0	COG5433@1|root,COG5433@2|Bacteria,1PY8T@1224|Proteobacteria,2UGIG@28211|Alphaproteobacteria,2JZ89@204441|Rhodospirillales	204441|Rhodospirillales	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_assoc
DTH2_k127_4411210_2	314278.NB231_07762	1.057e-28	124.0	COG5433@1|root,COG5433@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_assoc
DTH2_k127_4411210_0	686340.Metal_3936	1.13e-46	169.0	COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,1S8TU@1236|Gammaproteobacteria,1XFM1@135618|Methylococcales	135618|Methylococcales	S	Cupin domain	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2
DTH2_k127_441748_1	1238182.C882_4474	7.97e-24	102.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,2JPAI@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
DTH2_k127_441748_0	118005.AWNK01000007_gene720	1.073e-26	123.0	291BV@1|root,2ZNYU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4431883_6	517418.Ctha_2133	2.832e-10	65.0	COG0399@1|root,COG0399@2|Bacteria,1FEWK@1090|Chlorobi	1090|Chlorobi	H	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.33	ko:K20429	-	-	R02773	RC00006,RC00781	ko00000,ko01000	-	-	-	DegT_DnrJ_EryC1
DTH2_k127_4431883_4	1121438.JNJA01000001_gene2202	1.023e-21	102.0	COG0457@1|root,COG0457@2|Bacteria,1REFJ@1224|Proteobacteria,42REI@68525|delta/epsilon subdivisions,2WN9F@28221|Deltaproteobacteria,2MB58@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
DTH2_k127_4431883_3	338966.Ppro_3338	1.35e-28	132.0	COG1032@1|root,COG1216@1|root,COG1032@2|Bacteria,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,42U4I@68525|delta/epsilon subdivisions,2WPIS@28221|Deltaproteobacteria,43V77@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
DTH2_k127_4431883_2	518766.Rmar_2230	5.971e-30	137.0	COG0438@1|root,COG0457@1|root,COG2227@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG2227@2|Bacteria,4P78Y@976|Bacteroidetes	976|Bacteroidetes	H	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
DTH2_k127_4431883_0	765911.Thivi_0693	5.846e-228	756.0	COG0784@1|root,COG2198@1|root,COG4564@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG4564@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2V3@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DTH2_k127_4431883_5	261292.Nit79A3_3200	2.079e-11	68.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VH4X@28216|Betaproteobacteria,374R9@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM TonB-dependent receptor, plug	-	-	-	ko:K02014,ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.1,1.B.14.10	-	-	Plug,TonB_dep_Rec
DTH2_k127_4433035_3	1274374.CBLK010000013_gene4247	4.209e-07	55.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HJN1@91061|Bacilli,26Y79@186822|Paenibacillaceae	91061|Bacilli	CO	thiol-disulfide isomerase and thioredoxins	yneN	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
DTH2_k127_4433035_4	207954.MED92_04387	0.0002138	50.0	COG0848@1|root,COG0848@2|Bacteria,1PQKY@1224|Proteobacteria,1SG1V@1236|Gammaproteobacteria,1XPYS@135619|Oceanospirillales	135619|Oceanospirillales	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
DTH2_k127_4433035_0	933262.AXAM01000042_gene1835	2.514e-211	668.0	COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2MKAP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
DTH2_k127_4433035_1	933262.AXAM01000049_gene3264	9.271e-132	438.0	COG0859@1|root,COG0859@2|Bacteria,1P0ST@1224|Proteobacteria	1224|Proteobacteria	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4433035_2	933262.AXAM01000049_gene3265	1.774e-61	215.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,2MIGM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM lipopolysaccharide heptosyltransferase II	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
DTH2_k127_446224_0	383372.Rcas_3215	3.878e-106	353.0	COG0673@1|root,COG0673@2|Bacteria,2G7R0@200795|Chloroflexi,377Y3@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_446224_2	903818.KI912268_gene1338	1.119e-93	318.0	COG0275@1|root,COG0275@2|Bacteria,3Y31S@57723|Acidobacteria	57723|Acidobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_5
DTH2_k127_446224_3	247490.KSU1_D0660	1.279e-46	178.0	COG1386@1|root,COG1386@2|Bacteria,2IZNB@203682|Planctomycetes	203682|Planctomycetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
DTH2_k127_446224_1	1089550.ATTH01000001_gene1688	8.853e-103	346.0	COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,1FISB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	L	NUDIX domain	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
DTH2_k127_4493353_1	1142394.PSMK_15660	6.422e-17	93.0	COG3147@1|root,COG3147@2|Bacteria,2IXFB@203682|Planctomycetes	203682|Planctomycetes	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4493353_2	1129794.C427_2648	3.726e-05	47.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,467FY@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Integrase core domain	ISPlu1B	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
DTH2_k127_4493353_0	886293.Sinac_1778	1.42e-97	334.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,2IXA1@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA
DTH2_k127_4558810_0	1379858.N508_01560	1.758e-199	639.0	COG0370@1|root,COG0370@2|Bacteria,2GFAZ@200930|Deferribacteres	200930|Deferribacteres	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
DTH2_k127_4558810_1	207954.MED92_11714	3.278e-38	154.0	COG0697@1|root,COG0697@2|Bacteria,1N8SF@1224|Proteobacteria,1SJ8C@1236|Gammaproteobacteria,1XPUW@135619|Oceanospirillales	135619|Oceanospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DTH2_k127_4558810_2	1142394.PSMK_13590	1.055e-35	140.0	COG1762@1|root,COG1762@2|Bacteria,2IZ73@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	2.7.1.202	ko:K02768	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
DTH2_k127_4558810_3	1142394.PSMK_03050	4.221e-34	140.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
DTH2_k127_4678071_0	1142394.PSMK_14320	2.054e-20	96.0	COG2165@1|root,COG2165@2|Bacteria,2J10X@203682|Planctomycetes	203682|Planctomycetes	U	Pfam:N_methyl_2	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
DTH2_k127_4678071_1	314230.DSM3645_07535	3.712e-07	59.0	COG2165@1|root,COG2165@2|Bacteria,2J10X@203682|Planctomycetes	203682|Planctomycetes	U	Pfam:N_methyl_2	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
DTH2_k127_4680930_1	278957.ABEA03000160_gene49	2.713e-14	86.0	COG1404@1|root,COG1404@2|Bacteria,46XYP@74201|Verrucomicrobia,3K8MU@414999|Opitutae	414999|Opitutae	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4680930_0	886293.Sinac_1391	6.581e-42	158.0	COG0745@1|root,COG0745@2|Bacteria,2IZAH@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Response_reg
DTH2_k127_4793807_2	1205908.AKXW01000066_gene2909	1.02e-05	55.0	2BZ7H@1|root,34C4G@2|Bacteria,1P3BN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4793807_0	1396418.BATQ01000041_gene6309	2.823e-120	404.0	COG0443@1|root,COG0443@2|Bacteria,46SDM@74201|Verrucomicrobia,2ITH0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	MreB/Mbl protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
DTH2_k127_4793807_1	1205908.AKXW01000066_gene2907	2.42e-07	63.0	COG3793@1|root,COG3793@2|Bacteria,1NS76@1224|Proteobacteria	1224|Proteobacteria	P	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
DTH2_k127_4883070_1	1267534.KB906761_gene1195	2.517e-71	241.0	COG3957@1|root,COG3957@2|Bacteria,3Y3XU@57723|Acidobacteria,2JKSB@204432|Acidobacteriia	204432|Acidobacteriia	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
DTH2_k127_4883070_0	420324.KI912022_gene340	0.0	1308.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,1JT1D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
DTH2_k127_4883070_2	649638.Trad_0907	3.97e-54	197.0	COG4284@1|root,COG4284@2|Bacteria	2|Bacteria	G	Utp--glucose-1-phosphate uridylyltransferase	CP_1013	-	2.7.7.23,2.7.7.83	ko:K00972,ko:K11442	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00361,M00362	R00416	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
DTH2_k127_4968062_0	626939.HMPREF9443_00844	2.183e-112	381.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,4H35U@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
DTH2_k127_4981193_0	1215092.PA6_056_00150	3.152e-245	763.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria,1YH30@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
DTH2_k127_5013197_2	573413.Spirs_1686	6.197e-17	85.0	COG0071@1|root,COG0071@2|Bacteria,2JAWI@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DTH2_k127_5013197_1	926566.Terro_4136	1.622e-23	106.0	COG0071@1|root,COG0071@2|Bacteria,3Y4TM@57723|Acidobacteria,2JJFI@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DTH2_k127_5013197_3	251221.35213064	6.393e-17	87.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	badR	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
DTH2_k127_5013197_0	317936.Nos7107_1151	5.92e-66	233.0	COG1073@1|root,COG1073@2|Bacteria,1G2EP@1117|Cyanobacteria,1HKEM@1161|Nostocales	1117|Cyanobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S9
DTH2_k127_5013601_2	247490.KSU1_C1551	7.466e-17	91.0	COG1376@1|root,COG1376@2|Bacteria,2J0C4@203682|Planctomycetes	203682|Planctomycetes	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
DTH2_k127_5013601_1	195103.CPF_2633	4.542e-33	136.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,36JPF@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
DTH2_k127_5013601_0	314230.DSM3645_14130	1.326e-153	498.0	COG2256@1|root,COG2256@2|Bacteria,2IX8G@203682|Planctomycetes	203682|Planctomycetes	L	ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
DTH2_k127_5051300_2	138119.DSY2130	9.996e-88	302.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
DTH2_k127_5051300_3	247490.KSU1_C0304	3.937e-54	202.0	COG1039@1|root,COG1039@2|Bacteria,2IZ83@203682|Planctomycetes	203682|Planctomycetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5051300_1	1123242.JH636435_gene3015	3.058e-101	337.0	COG0253@1|root,COG0253@2|Bacteria,2IYCH@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
DTH2_k127_5051300_4	344747.PM8797T_05260	5.73e-33	134.0	COG0344@1|root,COG0344@2|Bacteria,2J0DJ@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	DUF4149,G3P_acyltransf
DTH2_k127_5094869_4	497964.CfE428DRAFT_4603	1.179e-60	224.0	COG0349@1|root,COG0349@2|Bacteria,46SUU@74201|Verrucomicrobia	74201|Verrucomicrobia	L	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
DTH2_k127_5094869_0	247490.KSU1_B0387	2.116e-134	442.0	COG1109@1|root,COG1109@2|Bacteria,2IXRS@203682|Planctomycetes	203682|Planctomycetes	G	PFAM Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DTH2_k127_5094869_9	999419.HMPREF1077_01411	2.064e-09	63.0	COG1708@1|root,COG1708@2|Bacteria,4NUA1@976|Bacteroidetes,2FUCM@200643|Bacteroidia,22YPU@171551|Porphyromonadaceae	976|Bacteroidetes	L	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
DTH2_k127_5094869_7	760568.Desku_0700	7.476e-32	129.0	COG1895@1|root,COG1895@2|Bacteria,1U5TF@1239|Firmicutes,2512S@186801|Clostridia,266IR@186807|Peptococcaceae	186801|Clostridia	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
DTH2_k127_5094869_8	1094980.Mpsy_2343	1.35e-24	110.0	COG0745@1|root,arCOG02452@1|root,arCOG02452@2157|Archaea,arCOG02592@2157|Archaea	2157|Archaea	T	cheY-homologous receiver domain	-	-	2.7.7.65,6.3.4.2	ko:K01937,ko:K02488	ko00240,ko01100,ko02020,ko04112,map00240,map01100,map02020,map04112	M00052,M00511	R00571,R00573,R08057	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	HATPase_c,PAS_4,PAS_9,Response_reg
DTH2_k127_5094869_5	234267.Acid_0302	3.712e-59	213.0	COG0602@1|root,COG0602@2|Bacteria,3Y2UA@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
DTH2_k127_5094869_6	237368.SCABRO_01639	1.429e-54	208.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH2_k127_5094869_3	756272.Plabr_1647	2.173e-72	265.0	COG2804@1|root,COG2804@2|Bacteria,2IXVD@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE
DTH2_k127_5094869_1	1123508.JH636444_gene5181	8.655e-107	358.0	COG2805@1|root,COG2805@2|Bacteria,2IX6Y@203682|Planctomycetes	203682|Planctomycetes	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DTH2_k127_5094869_2	644282.Deba_1899	1.186e-75	273.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
DTH2_k127_5101840_4	1229512.BPAA_524	0.0001164	46.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1HX52@117743|Flavobacteriia,3IV6D@39782|Blattabacteriaceae	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
DTH2_k127_5101840_3	886293.Sinac_6235	2.311e-09	68.0	COG2165@1|root,COG2165@2|Bacteria,2J25G@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM prepilin-type N-terminal cleavage methylation domain	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
DTH2_k127_5101840_0	530564.Psta_3847	5.04e-58	214.0	COG0618@1|root,COG0618@2|Bacteria,2IYQ0@203682|Planctomycetes	203682|Planctomycetes	S	phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
DTH2_k127_5101840_2	1210884.HG799464_gene10393	7.671e-31	126.0	COG0802@1|root,COG0802@2|Bacteria,2J06N@203682|Planctomycetes	203682|Planctomycetes	S	ATPase or kinase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
DTH2_k127_5101840_1	886293.Sinac_5349	2.668e-45	173.0	COG0611@1|root,COG0611@2|Bacteria,2IZG9@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DTH2_k127_5104912_3	314230.DSM3645_11122	9.877e-25	108.0	COG1917@1|root,COG1917@2|Bacteria,2J1N5@203682|Planctomycetes	203682|Planctomycetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5104912_2	344747.PM8797T_09134	3.105e-28	117.0	COG1695@1|root,COG1695@2|Bacteria,2J1J6@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
DTH2_k127_5104912_1	237368.SCABRO_03945	2.055e-89	308.0	COG0758@1|root,COG0758@2|Bacteria,2IX3D@203682|Planctomycetes	203682|Planctomycetes	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
DTH2_k127_5104912_0	331113.SNE_B24410	4.401e-230	724.0	COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae	204428|Chlamydiae	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
DTH2_k127_5104912_4	179408.Osc7112_4373	1.35e-10	74.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
DTH2_k127_5116539_2	1242864.D187_010163	1.068e-32	132.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2WJ4G@28221|Deltaproteobacteria,2YU5P@29|Myxococcales	28221|Deltaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
DTH2_k127_5116539_0	1304284.L21TH_0672	7.483e-84	291.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,36E1B@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
DTH2_k127_5116539_1	555088.DealDRAFT_2075	2.355e-61	217.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5137241_6	1410618.JNKI01000019_gene227	0.0005002	48.0	COG2063@1|root,COG2063@2|Bacteria,1V4W8@1239|Firmicutes,4H4FZ@909932|Negativicutes	909932|Negativicutes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
DTH2_k127_5137241_5	1304875.JAFZ01000002_gene121	6.316e-05	54.0	COG1261@1|root,COG1261@2|Bacteria,3TBHC@508458|Synergistetes	508458|Synergistetes	N	TIGRFAM flagella basal body P-ring formation protein FlgA	-	-	-	ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	ChapFlgA
DTH2_k127_5137241_0	1123242.JH636434_gene5080	1.711e-84	287.0	COG4786@1|root,COG4786@2|Bacteria,2IXW0@203682|Planctomycetes	2|Bacteria	N	Flagellar basal body rod protein	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
DTH2_k127_5137241_3	237368.SCABRO_02735	9.518e-35	142.0	COG4786@1|root,COG4786@2|Bacteria,2IZUQ@203682|Planctomycetes	203682|Planctomycetes	N	Flagellar basal body rod FlgEFG protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Flg_bbr_C
DTH2_k127_5137241_1	237368.SCABRO_02736	5.707e-79	285.0	COG1749@1|root,COG1749@2|Bacteria,2IYJT@203682|Planctomycetes	203682|Planctomycetes	N	Flagellar hook protein FlgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
DTH2_k127_5137241_4	1304888.ATWF01000001_gene1886	6.201e-13	74.0	COG1843@1|root,COG1843@2|Bacteria,2GFW5@200930|Deferribacteres	200930|Deferribacteres	N	Required for flagellar hook formation. May act as a scaffolding protein	-	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
DTH2_k127_5137241_2	1121472.AQWN01000002_gene2098	5.713e-50	188.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,2646G@186807|Peptococcaceae	186801|Clostridia	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
DTH2_k127_5139844_3	1287116.X734_06245	5.159e-05	46.0	COG0454@1|root,COG0454@2|Bacteria,1RDCA@1224|Proteobacteria,2U7RY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DTH2_k127_5139844_0	886293.Sinac_3374	1.051e-215	682.0	COG0488@1|root,COG0488@2|Bacteria,2IWXR@203682|Planctomycetes	203682|Planctomycetes	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
DTH2_k127_5139844_2	555079.Toce_0386	4.161e-78	270.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,42FCT@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
DTH2_k127_5139844_1	497964.CfE428DRAFT_1748	3.794e-123	399.0	COG3392@1|root,COG3392@2|Bacteria,46WWM@74201|Verrucomicrobia	74201|Verrucomicrobia	H	PFAM D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
DTH2_k127_5145277_0	247490.KSU1_B0716	1.579e-158	518.0	COG0187@1|root,COG0187@2|Bacteria,2IXF8@203682|Planctomycetes	203682|Planctomycetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DTH2_k127_5155623_4	68170.KL590520_gene7966	4.99e-18	98.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179,ko:K13276	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	GH5,GH9	-	Cellulase,Glyco_hydro_42
DTH2_k127_5155623_0	574087.Acear_0203	1.493e-183	608.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TQJM@1239|Firmicutes,24CFC@186801|Clostridia	186801|Clostridia	C	TIGRFAM glycerol-3-phosphate dehydrogenase, anaerobic, C subunit	glpC	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
DTH2_k127_5155623_2	604354.TSIB_1126	3.813e-36	154.0	COG1906@1|root,arCOG04354@2157|Archaea,2XX2X@28890|Euryarchaeota,243P4@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
DTH2_k127_5155623_6	1190603.AJYD01000068_gene3242	1.815e-07	53.0	2AWWW@1|root,31NUE@2|Bacteria,1QKI3@1224|Proteobacteria,1TIN7@1236|Gammaproteobacteria,1XZD4@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5155623_1	278963.ATWD01000001_gene3347	3.386e-67	246.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM-like,F5_F8_type_C,Pectate_lyase_3
DTH2_k127_5155623_5	1484157.PSNIH2_20305	7.303e-11	63.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	IS30 family	-	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
DTH2_k127_5155623_3	392500.Swoo_4367	1.135e-30	138.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	COG2211 Na melibiose symporter and related transporters	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
DTH2_k127_5160134_0	314230.DSM3645_10162	2.297e-85	290.0	COG0524@1|root,COG0524@2|Bacteria,2IXGC@203682|Planctomycetes	203682|Planctomycetes	H	PFAM PfkB	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DTH2_k127_5160134_2	1210884.HG799462_gene8889	1.078e-26	116.0	COG1514@1|root,COG1514@2|Bacteria,2J0NQ@203682|Planctomycetes	203682|Planctomycetes	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
DTH2_k127_5167407_0	247490.KSU1_C0568	6.677e-85	291.0	COG0502@1|root,COG0502@2|Bacteria,2IXTG@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
DTH2_k127_5167407_3	344747.PM8797T_31840	6.323e-26	114.0	2E296@1|root,32XEW@2|Bacteria,2J070@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5167407_1	1094980.Mpsy_1173	2.359e-38	157.0	COG0523@1|root,arCOG01232@2157|Archaea,2Y8HY@28890|Euryarchaeota,2NAAU@224756|Methanomicrobia	224756|Methanomicrobia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
DTH2_k127_5167407_2	1121430.JMLG01000007_gene2601	9.915e-28	120.0	COG1418@1|root,COG1418@2|Bacteria,1V4Z1@1239|Firmicutes,24I7X@186801|Clostridia	186801|Clostridia	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5167407_4	931626.Awo_c10690	4.144e-07	53.0	2C5Z2@1|root,32A20@2|Bacteria,1V5CS@1239|Firmicutes,24M7C@186801|Clostridia,25YF1@186806|Eubacteriaceae	186801|Clostridia	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
DTH2_k127_5177830_1	1192034.CAP_3054	2.352e-51	200.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2YTV4@29|Myxococcales	28221|Deltaproteobacteria	U	type IV pilus secretin PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
DTH2_k127_5177830_0	697281.Mahau_1082	2.826e-74	266.0	COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,1U23Q@1239|Firmicutes,24CZ9@186801|Clostridia,42J9U@68295|Thermoanaerobacterales	186801|Clostridia	K	Sensory domain found in PocR	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,PocR
DTH2_k127_5177830_2	1205753.A989_05397	2.128e-25	110.0	COG1366@1|root,COG1366@2|Bacteria,1PCVS@1224|Proteobacteria,1SCT3@1236|Gammaproteobacteria,1X73U@135614|Xanthomonadales	135614|Xanthomonadales	T	Belongs to the anti-sigma-factor antagonist family	spoIIAA	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
DTH2_k127_5181129_0	1121403.AUCV01000068_gene2197	1.672e-99	330.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,2MIEC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
DTH2_k127_5181129_2	1397527.Q670_14300	0.0001622	48.0	COG2267@1|root,COG2267@2|Bacteria,1RAQZ@1224|Proteobacteria,1S2YX@1236|Gammaproteobacteria,1XJ98@135619|Oceanospirillales	135619|Oceanospirillales	I	COG2267 Lysophospholipase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
DTH2_k127_5190874_7	237368.SCABRO_01912	0.0005415	48.0	2DVEZ@1|root,33VK5@2|Bacteria	2|Bacteria	S	Outer membrane protein (OmpH-like)	-	-	-	-	-	-	-	-	-	-	-	-	OmpH
DTH2_k127_5190874_4	679199.HMPREF9332_01716	2.133e-60	222.0	COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,2FMZE@200643|Bacteroidia,1WD1P@1283313|Alloprevotella	976|Bacteroidetes	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
DTH2_k127_5190874_0	1142394.PSMK_05870	2.398e-131	432.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2IZ4S@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108,4.2.1.59	ko:K02535,ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
DTH2_k127_5190874_5	530564.Psta_1866	2.702e-53	198.0	COG1043@1|root,COG1043@2|Bacteria,2IZR6@203682|Planctomycetes	203682|Planctomycetes	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
DTH2_k127_5190874_3	247490.KSU1_B0556	4.87e-76	266.0	COG0673@1|root,COG0673@2|Bacteria,2IXAX@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_5190874_2	313628.LNTAR_02467	1.309e-83	296.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DTH2_k127_5190874_1	1254432.SCE1572_26605	4.064e-94	320.0	COG0327@1|root,COG0327@2|Bacteria,1R34P@1224|Proteobacteria,42MAY@68525|delta/epsilon subdivisions,2X5HJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
DTH2_k127_521580_0	1210884.HG799465_gene11874	3.216e-80	290.0	COG5316@1|root,COG5316@2|Bacteria,2IZ9P@203682|Planctomycetes	203682|Planctomycetes	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
DTH2_k127_521580_1	1514668.JOOA01000002_gene1160	1.225e-17	94.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TT4A@1239|Firmicutes,24EIA@186801|Clostridia,3WIEQ@541000|Ruminococcaceae	186801|Clostridia	GK	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DTH2_k127_5224500_0	1485543.JMME01000014_gene323	6.34e-57	212.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,4H294@909932|Negativicutes	909932|Negativicutes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
DTH2_k127_5224500_1	1499967.BAYZ01000111_gene2946	5.63e-46	189.0	COG0642@1|root,COG2205@2|Bacteria,2NS4W@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DTH2_k127_5224500_2	326423.RBAM_018130	2.489e-15	79.0	COG0745@1|root,COG0745@2|Bacteria,1TPRM@1239|Firmicutes,4HAMG@91061|Bacilli,1ZQ5Q@1386|Bacillus	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DTH2_k127_522831_1	608538.HTH_0999	3.892e-38	146.0	COG0001@1|root,COG0001@2|Bacteria,2G3VU@200783|Aquificae	200783|Aquificae	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH2_k127_522831_0	237368.SCABRO_00988	1.864e-147	477.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	nirJ	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DTH2_k127_522831_2	269797.Mbar_A1458	2.103e-29	119.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2N9ER@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DTH2_k127_5264518_0	765911.Thivi_0693	2.745e-210	683.0	COG0784@1|root,COG2198@1|root,COG4564@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG4564@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2V3@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DTH2_k127_5264518_1	96561.Dole_3264	1.445e-21	99.0	COG0784@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
DTH2_k127_5266208_0	56780.SYN_00557	2.635e-161	513.0	COG0191@1|root,COG0191@2|Bacteria,1NUAP@1224|Proteobacteria	1224|Proteobacteria	G	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
DTH2_k127_5273124_0	525903.Taci_1750	5.452e-164	526.0	COG0369@1|root,COG1151@2|Bacteria,3TA79@508458|Synergistetes	508458|Synergistetes	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
DTH2_k127_5273124_1	338966.Ppro_2801	3.099e-30	123.0	COG1917@1|root,COG1917@2|Bacteria,1RJX2@1224|Proteobacteria,42TVK@68525|delta/epsilon subdivisions,2WQ2T@28221|Deltaproteobacteria,43SQH@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DTH2_k127_5273124_3	1047013.AQSP01000144_gene912	2.969e-29	122.0	COG1959@1|root,COG1959@2|Bacteria,2NQ8B@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, BadM Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DTH2_k127_5273124_4	530564.Psta_0238	0.0001803	47.0	COG2165@1|root,COG2165@2|Bacteria,2J069@203682|Planctomycetes	203682|Planctomycetes	NU	Protein of unknown function (DUF1559)	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_10
DTH2_k127_5273124_2	756272.Plabr_4017	6.389e-30	128.0	COG1385@1|root,COG1385@2|Bacteria,2IZRM@203682|Planctomycetes	203682|Planctomycetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
DTH2_k127_5273124_5	272844.PAB1709	0.0009906	45.0	COG2461@1|root,arCOG01472@2157|Archaea,2Y2CG@28890|Euryarchaeota,245FH@183968|Thermococci	183968|Thermococci	S	PAS domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
DTH2_k127_5273973_0	880073.Calab_0031	2.954e-99	330.0	COG2017@1|root,COG2017@2|Bacteria,2NQA5@2323|unclassified Bacteria	2|Bacteria	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
DTH2_k127_5273973_1	1089553.Tph_c20550	1.558e-90	319.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,42FM5@68295|Thermoanaerobacterales	186801|Clostridia	EH	Anthranilate synthase component I, N terminal region	pabB	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
DTH2_k127_5273973_2	223184.AS25_01505	4.811e-39	151.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,1W8DB@1268|Micrococcaceae	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
DTH2_k127_5298876_4	1131462.DCF50_p297	6.021e-58	218.0	COG0685@1|root,COG0685@2|Bacteria,1W739@1239|Firmicutes,25NME@186801|Clostridia,260RW@186807|Peptococcaceae	186801|Clostridia	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
DTH2_k127_5298876_0	1033806.HTIA_2365	1.352e-132	435.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM Nickel-dependent hydrogenase, large subunit	mvhA	-	1.12.1.2,1.12.1.3,1.12.1.5,1.8.98.5	ko:K00436,ko:K14126,ko:K17993	ko00680,ko00920,map00680,map00920	-	R00019,R00700,R10390,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
DTH2_k127_5298876_2	237368.SCABRO_02488	6.459e-82	280.0	COG1941@1|root,COG1941@2|Bacteria,2IXWB@203682|Planctomycetes	203682|Planctomycetes	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
DTH2_k127_5298876_1	880073.Calab_0418	2.953e-92	310.0	COG0543@1|root,COG0543@2|Bacteria,2NPFH@2323|unclassified Bacteria	2|Bacteria	CH	Oxidoreductase NAD-binding domain	asrB	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K02823,ko:K16951	ko00240,ko00920,ko01100,ko01120,map00240,map00920,map01100,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS12555	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DTH2_k127_5298876_3	519442.Huta_2602	6.453e-76	267.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
DTH2_k127_5298876_5	1408254.T458_01465	5.035e-49	182.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,4HB7Q@91061|Bacilli,26S0A@186822|Paenibacillaceae	91061|Bacilli	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
DTH2_k127_5303149_9	926560.KE387025_gene4045	1.83e-08	66.0	COG1520@1|root,COG1520@2|Bacteria,1WMGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
DTH2_k127_5303149_8	3055.DAA00924	4.846e-13	75.0	COG0355@1|root,KOG1758@2759|Eukaryota,37UFP@33090|Viridiplantae,34MRU@3041|Chlorophyta	3041|Chlorophyta	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
DTH2_k127_5303149_0	521674.Plim_0176	4.064e-208	656.0	COG0055@1|root,COG0055@2|Bacteria,2IY7P@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
DTH2_k127_5303149_2	344747.PM8797T_28839	5.545e-50	189.0	COG0224@1|root,COG0224@2|Bacteria,2IXDI@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
DTH2_k127_5303149_1	344747.PM8797T_28844	9.798e-197	625.0	COG0056@1|root,COG0056@2|Bacteria,2IXN5@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
DTH2_k127_5303149_6	525904.Tter_0066	1.372e-19	96.0	COG0712@1|root,COG0712@2|Bacteria,2NPV0@2323|unclassified Bacteria	2|Bacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02109,ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
DTH2_k127_5303149_10	946077.W5A_00550	9.616e-06	55.0	COG0711@1|root,COG0711@2|Bacteria,4NQKA@976|Bacteroidetes,1I239@117743|Flavobacteriia	976|Bacteroidetes	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
DTH2_k127_5303149_7	926549.KI421517_gene2269	5.609e-16	80.0	COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,47S5V@768503|Cytophagia	976|Bacteroidetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
DTH2_k127_5303149_3	886293.Sinac_6873	2.703e-35	145.0	COG0356@1|root,COG0356@2|Bacteria,2IZP5@203682|Planctomycetes	203682|Planctomycetes	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
DTH2_k127_5303149_11	944481.JAFP01000001_gene862	0.0003627	47.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,437BS@68525|delta/epsilon subdivisions,2XA00@28221|Deltaproteobacteria,2M7D0@213113|Desulfurellales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
DTH2_k127_5303149_4	936573.HMPREF1147_0916	3.76e-32	131.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,4H2AC@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DTH2_k127_531665_5	586416.GZ22_06900	0.0002005	53.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,4HAAY@91061|Bacilli	91061|Bacilli	N	One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0008150,GO:0009288,GO:0009425,GO:0009605,GO:0016020,GO:0040011,GO:0042221,GO:0042330,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0050896,GO:0050918,GO:0071944	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
DTH2_k127_531665_3	1230341.MJ3_02447	8.752e-21	96.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,4HC56@91061|Bacilli	91061|Bacilli	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliY	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032879,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902021,GO:2000145	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
DTH2_k127_531665_0	1321781.HMPREF1985_02063	7.808e-166	545.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,4H2W2@909932|Negativicutes	909932|Negativicutes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
DTH2_k127_531665_2	269799.Gmet_0429	4.755e-39	156.0	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,42QQ8@68525|delta/epsilon subdivisions,2WMX3@28221|Deltaproteobacteria,43U1R@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, FliA WhiG family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
DTH2_k127_531665_4	452637.Oter_0443	1.532e-07	61.0	2EI2N@1|root,33BU2@2|Bacteria,46WEF@74201|Verrucomicrobia,3K8D4@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_531665_1	1142394.PSMK_27340	5.508e-72	259.0	COG2208@1|root,COG4936@1|root,COG2208@2|Bacteria,COG4936@2|Bacteria,2IWVF@203682|Planctomycetes	203682|Planctomycetes	T	FHA domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	FHA,GAF_2,SpoIIE
DTH2_k127_5321924_7	1120919.AUBI01000005_gene865	6.931e-69	246.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,2JPJK@204441|Rhodospirillales	204441|Rhodospirillales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DTH2_k127_5321924_4	1121428.DESHY_160143___1	6.805e-113	381.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,260ZD@186807|Peptococcaceae	186801|Clostridia	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
DTH2_k127_5321924_6	1035308.AQYY01000001_gene1729	1.142e-79	281.0	2DV20@1|root,33TMX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5321924_5	1035308.AQYY01000001_gene1730	3.655e-106	356.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1USCB@1239|Firmicutes,24FET@186801|Clostridia	186801|Clostridia	IQ	PFAM Short-chain dehydrogenase reductase SDR	srlD	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
DTH2_k127_5321924_2	1120942.AUBM01000010_gene1308	2.525e-152	499.0	COG1063@1|root,COG1063@2|Bacteria,2H3Y2@201174|Actinobacteria,4D42Y@85005|Actinomycetales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N
DTH2_k127_5321924_3	575540.Isop_3440	1.663e-150	490.0	COG1070@1|root,COG1070@2|Bacteria,2IXYW@203682|Planctomycetes	203682|Planctomycetes	G	COG1070 Sugar (pentulose and hexulose)	-	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
DTH2_k127_5321924_8	742725.HMPREF9450_01252	1.492e-63	231.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,4NEM0@976|Bacteroidetes,2FWDE@200643|Bacteroidia	976|Bacteroidetes	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short,adh_short_C2
DTH2_k127_5321924_0	1499967.BAYZ01000173_gene5824	3.128e-188	596.0	COG4806@1|root,COG4806@2|Bacteria	2|Bacteria	G	L-rhamnose isomerase activity	rhaA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008740,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0022607,GO:0030145,GO:0030246,GO:0032991,GO:0033296,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046872,GO:0046914,GO:0048029,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901575	2.7.1.5,5.3.1.14	ko:K00848,ko:K01813	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R02437,R03014	RC00002,RC00017,RC00434	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3092,iUMNK88_1353.UMNK88_4739	RhaA
DTH2_k127_5321924_9	926559.JoomaDRAFT_3816	5.699e-46	178.0	COG2207@1|root,COG2207@2|Bacteria,4NHZP@976|Bacteroidetes,1HXJU@117743|Flavobacteriia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
DTH2_k127_5321924_1	1499967.BAYZ01000154_gene1465	2.849e-167	533.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0008736,GO:0008790,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019571,GO:0042354,GO:0042355,GO:0042802,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046372,GO:0071704,GO:1901575	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c30720,ic_1306.c3371	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
DTH2_k127_5323360_1	1142394.PSMK_01490	5.918e-35	146.0	COG0457@1|root,COG0457@2|Bacteria	1142394.PSMK_01490|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5323360_2	329726.AM1_3590	0.0002281	47.0	COG0268@1|root,COG0268@2|Bacteria,1G7PV@1117|Cyanobacteria	1117|Cyanobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
DTH2_k127_5323360_0	521674.Plim_2449	1.491e-121	410.0	COG0557@1|root,COG0557@2|Bacteria,2IX1J@203682|Planctomycetes	203682|Planctomycetes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
DTH2_k127_532464_1	1396141.BATP01000020_gene90	5.133e-24	104.0	COG1695@1|root,COG1695@2|Bacteria,46WGD@74201|Verrucomicrobia,2IW9N@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
DTH2_k127_532464_2	1321778.HMPREF1982_02442	1.736e-15	91.0	COG4219@1|root,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,249NV@186801|Clostridia,26950@186813|unclassified Clostridiales	186801|Clostridia	KT	Psort location CytoplasmicMembrane, score	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	NAGPA,Peptidase_M56
DTH2_k127_532464_0	290402.Cbei_3103	3.757e-34	151.0	COG4219@1|root,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,249NV@186801|Clostridia,36HDP@31979|Clostridiaceae	186801|Clostridia	KT	Peptidase, M56	blaR	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	NAGPA,Peptidase_M56
DTH2_k127_5397189_1	344747.PM8797T_01514	1.071e-98	333.0	COG0809@1|root,COG0809@2|Bacteria,2IWS2@203682|Planctomycetes	203682|Planctomycetes	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
DTH2_k127_5397189_0	1123242.JH636435_gene1081	1.081e-162	522.0	COG1219@1|root,COG1219@2|Bacteria,2IXDS@203682|Planctomycetes	203682|Planctomycetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
DTH2_k127_5397189_2	344747.PM8797T_11234	1.916e-23	108.0	COG2165@1|root,COG2165@2|Bacteria,2J10X@203682|Planctomycetes	203682|Planctomycetes	U	Pfam:N_methyl_2	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
DTH2_k127_5421121_0	644282.Deba_1938	2.326e-47	177.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
DTH2_k127_5421121_2	556263.FSEG_00020	5.736e-19	89.0	COG3830@1|root,COG3830@2|Bacteria,37AVP@32066|Fusobacteria	32066|Fusobacteria	T	ACT domain protein	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
DTH2_k127_5425253_2	1123508.JH636444_gene5169	5.244e-68	256.0	COG1256@1|root,COG1256@2|Bacteria,2IXRV@203682|Planctomycetes	203682|Planctomycetes	N	flagellar hook-associated protein	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
DTH2_k127_5425253_3	237368.SCABRO_02727	1.254e-16	92.0	COG1344@1|root,COG1344@2|Bacteria,2J11W@203682|Planctomycetes	203682|Planctomycetes	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	-	-	-	-	-	-	-	-	-	Flagellin_N
DTH2_k127_5425253_1	351627.Csac_1682	2.055e-70	257.0	COG0438@1|root,COG0457@1|root,COG2227@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG2227@2|Bacteria,1U9Z2@1239|Firmicutes,2494K@186801|Clostridia,42IVC@68295|Thermoanaerobacterales	186801|Clostridia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_25,TPR_8
DTH2_k127_5425253_0	309799.DICTH_0325	8.611e-84	284.0	COG1028@1|root,COG1028@2|Bacteria	309799.DICTH_0325|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5463389_1	452637.Oter_1383	5.867e-26	109.0	COG1069@1|root,COG1069@2|Bacteria,46UI3@74201|Verrucomicrobia,3K769@414999|Opitutae	414999|Opitutae	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
DTH2_k127_5463389_5	237368.SCABRO_03598	1.234e-15	78.0	2ED2F@1|root,336ZC@2|Bacteria,2J4H4@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
DTH2_k127_5463389_3	1183377.Py04_0692	6.552e-21	96.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
DTH2_k127_5463389_4	314230.DSM3645_22054	2.087e-16	84.0	COG1959@1|root,COG1959@2|Bacteria,2J3HG@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DTH2_k127_5463389_2	521674.Plim_2057	2.336e-21	97.0	COG1366@1|root,COG1366@2|Bacteria,2J02R@203682|Planctomycetes	203682|Planctomycetes	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
DTH2_k127_5463389_0	1210884.HG799463_gene9325	7.278e-32	130.0	COG2172@1|root,COG2172@2|Bacteria,2J0BZ@203682|Planctomycetes	203682|Planctomycetes	T	COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase)	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
DTH2_k127_5478886_3	338963.Pcar_0760	1.28e-38	152.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,43SVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
DTH2_k127_5478886_0	1121423.JONT01000001_gene1960	1.374e-219	696.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,260S7@186807|Peptococcaceae	186801|Clostridia	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
DTH2_k127_5478886_2	1535287.JP74_08025	4.001e-61	237.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,NB-ARC,cNMP_binding
DTH2_k127_5478886_5	768671.ThimaDRAFT_4398	7.323e-27	123.0	COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,1RP6K@1236|Gammaproteobacteria,1X2EI@135613|Chromatiales	135613|Chromatiales	H	belongs to the carbohydrate kinase PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DTH2_k127_5478886_1	937774.TEQUI_0452	3.695e-159	521.0	COG0500@1|root,COG2021@1|root,COG2021@2|Bacteria,COG2226@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,3T1KJ@506|Alcaligenaceae	28216|Betaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
DTH2_k127_5478886_4	243231.GSU0402	6.051e-30	123.0	COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,42X8X@68525|delta/epsilon subdivisions,2WR9M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
DTH2_k127_5485233_2	478741.JAFS01000001_gene1376	4.606e-18	86.0	COG1057@1|root,COG1057@2|Bacteria,46T27@74201|Verrucomicrobia,37GT4@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DTH2_k127_5485233_0	745014.OMB55_00010890	3.274e-47	176.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1J6A5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271,ko:K12961	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036	-	-	-	SIS_2
DTH2_k127_5485233_1	452637.Oter_2975	2.461e-40	153.0	COG0673@1|root,COG0673@2|Bacteria,46UJ9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_55607_2	572477.Alvin_0229	3.658e-33	146.0	COG1216@1|root,COG1216@2|Bacteria,1NCRD@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH2_k127_55607_1	313612.L8106_01277	5.303e-38	161.0	COG0438@1|root,COG1215@1|root,COG1216@1|root,COG3914@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,COG3914@2|Bacteria,1FZUY@1117|Cyanobacteria,1H72J@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_31
DTH2_k127_55607_3	234267.Acid_4214	2.26e-08	61.0	2B6R1@1|root,31ZPU@2|Bacteria,3Y4VP@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_55607_0	760568.Desku_2664	9.45e-89	306.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
DTH2_k127_5587225_2	909663.KI867150_gene2871	1.162e-87	307.0	COG3039@1|root,COG3039@2|Bacteria,1QY2X@1224|Proteobacteria	1224|Proteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6
DTH2_k127_5587225_4	497964.CfE428DRAFT_3832	7.119e-14	83.0	COG1729@1|root,COG4105@1|root,COG1729@2|Bacteria,COG4105@2|Bacteria,46SYU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_16,TPR_6,YfiO
DTH2_k127_5587225_3	344747.PM8797T_14229	1.988e-22	104.0	COG2980@1|root,COG2980@2|Bacteria,2J05A@203682|Planctomycetes	203682|Planctomycetes	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
DTH2_k127_5587225_0	1142394.PSMK_25340	2.241e-193	623.0	COG0465@1|root,COG0465@2|Bacteria,2IWU2@203682|Planctomycetes	203682|Planctomycetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
DTH2_k127_5587225_1	1121918.ARWE01000001_gene2901	1.225e-142	468.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43U7Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
DTH2_k127_5604505_0	1168034.FH5T_04505	2.174e-196	619.0	COG0502@1|root,COG0502@2|Bacteria,4NEI7@976|Bacteroidetes,2FM8N@200643|Bacteroidia	976|Bacteroidetes	C	In Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
DTH2_k127_5604505_2	237368.SCABRO_01800	2.889e-111	371.0	COG0743@1|root,COG0743@2|Bacteria,2IY3M@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
DTH2_k127_5604505_3	1142394.PSMK_24590	2.051e-73	273.0	COG0265@1|root,COG0750@1|root,COG0265@2|Bacteria,COG0750@2|Bacteria,2IXWE@203682|Planctomycetes	203682|Planctomycetes	M	PDZ domain (Also known as DHR	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
DTH2_k127_5604505_1	1268635.Loa_02070	5.858e-118	386.0	COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase, family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
DTH2_k127_5621173_0	635013.TherJR_2600	2.638e-73	261.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
DTH2_k127_5621173_1	622637.KE124774_gene1689	1.398e-11	65.0	COG2801@1|root,COG2801@2|Bacteria,1MX69@1224|Proteobacteria,2TSIE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
DTH2_k127_5625492_1	909663.KI867150_gene2628	3.344e-269	850.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MR70@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
DTH2_k127_5625492_0	556261.HMPREF0240_00643	0.0	1057.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36F8M@31979|Clostridiaceae	186801|Clostridia	C	formate acetyltransferase	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
DTH2_k127_5625492_4	926692.AZYG01000047_gene2656	2.696e-73	254.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,3WAAU@53433|Halanaerobiales	186801|Clostridia	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DTH2_k127_5625492_7	661087.HMPREF1008_01337	1.49e-13	72.0	COG1141@1|root,COG1141@2|Bacteria,2GWHY@201174|Actinobacteria,4CYD7@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S single cluster domain of Ferredoxin I	fdx	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
DTH2_k127_5625492_3	1142394.PSMK_21340	2.151e-75	262.0	COG0052@1|root,COG0052@2|Bacteria,2IY9P@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
DTH2_k127_5625492_5	387092.NIS_1536	4.881e-60	221.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2YMQW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
DTH2_k127_5625492_2	1304875.JAFZ01000001_gene1632	1.616e-82	281.0	COG0528@1|root,COG0528@2|Bacteria,3TA8R@508458|Synergistetes	508458|Synergistetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DTH2_k127_5625492_6	314230.DSM3645_07585	2.192e-48	179.0	COG0233@1|root,COG0233@2|Bacteria,2IYYY@203682|Planctomycetes	203682|Planctomycetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
DTH2_k127_5646950_2	1380390.JIAT01000013_gene36	3.658e-16	85.0	COG1595@1|root,COG1595@2|Bacteria,2HQNV@201174|Actinobacteria,4CS9U@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
DTH2_k127_5646950_1	1541065.JRFE01000043_gene5186	2.894e-39	163.0	COG3012@1|root,COG3012@2|Bacteria,1GQ2M@1117|Cyanobacteria	1117|Cyanobacteria	S	SEC-C Motif Domain Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1186
DTH2_k127_5646950_0	485913.Krac_8102	2.591e-45	181.0	2FA33@1|root,342C2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5654658_0	247490.KSU1_C1241	1.419e-192	614.0	COG1217@1|root,COG1217@2|Bacteria,2IY3Q@203682|Planctomycetes	203682|Planctomycetes	T	membrane GTPase involved in stress response	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
DTH2_k127_5654658_5	1121097.JCM15093_2868	3.059e-06	53.0	arCOG05093@1|root,339N6@2|Bacteria,4NXVG@976|Bacteroidetes,2FUSZ@200643|Bacteroidia,4AS13@815|Bacteroidaceae	976|Bacteroidetes	S	COG NOG33517 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	DUF2582
DTH2_k127_5654658_4	1142394.PSMK_29770	2.796e-09	64.0	COG3023@1|root,COG3023@2|Bacteria,2J0EH@203682|Planctomycetes	203682|Planctomycetes	V	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
DTH2_k127_5654658_1	886293.Sinac_1310	4.125e-102	353.0	COG2812@1|root,COG2812@2|Bacteria,2IX1M@203682|Planctomycetes	203682|Planctomycetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
DTH2_k127_5654658_3	314230.DSM3645_28657	3.753e-69	239.0	COG0353@1|root,COG0353@2|Bacteria,2IXK5@203682|Planctomycetes	203682|Planctomycetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
DTH2_k127_5654658_2	314230.DSM3645_28652	8.857e-102	348.0	COG1508@1|root,COG1508@2|Bacteria,2IXGU@203682|Planctomycetes	203682|Planctomycetes	K	rna polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
DTH2_k127_5695821_2	1037409.BJ6T_21760	2.378e-61	220.0	2C2X7@1|root,31WBU@2|Bacteria,1P2EC@1224|Proteobacteria,2UV16@28211|Alphaproteobacteria,3JWR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
DTH2_k127_5695821_1	338966.Ppro_0408	1.33e-73	260.0	29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5695821_0	909663.KI867149_gene3179	1.251e-137	443.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2MR97@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
DTH2_k127_5697665_5	926569.ANT_17700	1.798e-12	71.0	COG0524@1|root,COG0524@2|Bacteria,2G67T@200795|Chloroflexi	200795|Chloroflexi	H	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
DTH2_k127_5697665_3	658086.HMPREF0994_03659	4.092e-110	364.0	COG0407@1|root,COG0407@2|Bacteria,1V3M9@1239|Firmicutes,25AY7@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH2_k127_5697665_1	1168034.FH5T_15275	1.498e-199	628.0	COG1904@1|root,COG1904@2|Bacteria,4NFHS@976|Bacteroidetes,2FMMW@200643|Bacteroidia	976|Bacteroidetes	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
DTH2_k127_5697665_4	763034.HMPREF9446_02313	1.044e-19	89.0	COG1904@1|root,COG1904@2|Bacteria,4NFHS@976|Bacteroidetes,2FMMW@200643|Bacteroidia,4AKR4@815|Bacteroidaceae	976|Bacteroidetes	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
DTH2_k127_5697665_0	1121335.Clst_2416	2.767e-255	793.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,248YA@186801|Clostridia	186801|Clostridia	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
DTH2_k127_5697665_2	886379.AEWI01000001_gene1806	5.466e-119	385.0	COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia,3XIZT@558415|Marinilabiliaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
DTH2_k127_5720697_0	1121382.JQKG01000033_gene3168	5.19e-125	408.0	COG0415@1|root,COG0415@2|Bacteria,1WM2P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
DTH2_k127_5720697_1	1125699.HMPREF9194_01778	4.889e-74	264.0	COG0738@1|root,COG0738@2|Bacteria,2J7KW@203691|Spirochaetes	203691|Spirochaetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH2_k127_5720697_2	37659.JNLN01000001_gene1543	1.986e-15	78.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,36FVA@31979|Clostridiaceae	186801|Clostridia	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
DTH2_k127_5727526_2	697281.Mahau_2177	6.97e-63	230.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
DTH2_k127_5727526_1	370438.PTH_1466	7.696e-84	285.0	COG0463@1|root,COG0463@2|Bacteria,1UI8D@1239|Firmicutes,247P4@186801|Clostridia,267CB@186807|Peptococcaceae	186801|Clostridia	H	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH2_k127_5727526_3	314285.KT71_05902	2.566e-10	74.0	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria	1224|Proteobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5727526_0	65393.PCC7424_5216	3.109e-142	460.0	COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria,3KH7H@43988|Cyanothece	1117|Cyanobacteria	C	Alcohol dehydrogenase GroES domain protein	-	-	-	ko:K12957	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH2_k127_5734468_1	35841.BT1A1_3283	8.605e-100	329.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,1ZBFX@1386|Bacillus	91061|Bacilli	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
DTH2_k127_5734468_0	401526.TcarDRAFT_0104	1.168e-104	368.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes	909932|Negativicutes	V	lipid A export permease ATP-binding protein MsbA	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
DTH2_k127_5734468_2	311424.DhcVS_293	9.421e-07	61.0	COG3567@1|root,COG3567@2|Bacteria,2G7F0@200795|Chloroflexi,34DDN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Phage portal protein, SPP1 Gp6-like	-	-	-	-	-	-	-	-	-	-	-	-	Phage_prot_Gp6
DTH2_k127_5746552_0	868595.Desca_0261	1.816e-91	306.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,260N0@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
DTH2_k127_5746552_1	1142394.PSMK_18480	3.334e-64	234.0	COG1989@1|root,COG1989@2|Bacteria,2IZQ8@203682|Planctomycetes	203682|Planctomycetes	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
DTH2_k127_5746552_2	237368.SCABRO_03873	3.236e-22	105.0	COG1360@1|root,COG1360@2|Bacteria,2IZSF@203682|Planctomycetes	203682|Planctomycetes	N	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
DTH2_k127_5746552_3	1123242.JH636438_gene5887	2.644e-19	95.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2IY17@203682|Planctomycetes	203682|Planctomycetes	S	competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
DTH2_k127_5763399_2	794903.OPIT5_10915	4.65e-24	108.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DTH2_k127_5763399_1	545695.TREAZ_0830	7.149e-111	369.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5763399_0	545695.TREAZ_3489	2.551e-119	399.0	28MXM@1|root,2ZB4M@2|Bacteria,2JAH5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5766381_1	656519.Halsa_1119	2.645e-60	214.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,3WAKB@53433|Halanaerobiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
DTH2_k127_5766381_0	1121405.dsmv_3372	4.888e-72	253.0	COG1141@1|root,COG2878@1|root,COG1141@2|Bacteria,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,42PTG@68525|delta/epsilon subdivisions,2WKYG@28221|Deltaproteobacteria,2MIM0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_7
DTH2_k127_5766381_2	497964.CfE428DRAFT_0921	2.128e-58	209.0	COG4112@1|root,COG4112@2|Bacteria,46V3C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5766381_3	237368.SCABRO_04038	3.051e-56	211.0	COG1477@1|root,COG3901@1|root,COG1477@2|Bacteria,COG3901@2|Bacteria,2IYYX@203682|Planctomycetes	203682|Planctomycetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE,FMN_bind
DTH2_k127_5766381_4	742738.HMPREF9460_01640	5.076e-48	178.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,267WF@186813|unclassified Clostridiales	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH2_k127_5784385_0	471223.GWCH70_1466	3.341e-130	446.0	COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,4HBKW@91061|Bacilli,1WG1B@129337|Geobacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
DTH2_k127_5806545_1	694431.DESACE_00405	7.896e-06	51.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2M68X@213113|Desulfurellales	28221|Deltaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
DTH2_k127_5806545_0	857293.CAAU_2260	3.113e-169	549.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,36DVT@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
DTH2_k127_5816649_2	1142394.PSMK_15660	9.139e-43	166.0	COG3147@1|root,COG3147@2|Bacteria,2IXFB@203682|Planctomycetes	203682|Planctomycetes	S	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5816649_3	1142394.PSMK_15650	5.377e-21	107.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
DTH2_k127_5816649_1	313628.LNTAR_12676	3.283e-91	314.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	pilH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH2_k127_5816649_0	313628.LNTAR_12671	2.416e-168	550.0	COG2217@1|root,COG2217@2|Bacteria	2|Bacteria	P	Heavy metal translocating P-type atpase	cadA	-	3.6.3.3,3.6.3.5,3.6.3.54	ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5,3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
DTH2_k127_5816649_4	570952.ATVH01000014_gene2232	6.587e-20	103.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2JQ87@204441|Rhodospirillales	204441|Rhodospirillales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
DTH2_k127_5816649_5	511.JT27_15255	1.015e-13	76.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,3T2ZZ@506|Alcaligenaceae	28216|Betaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
DTH2_k127_5829864_5	1168289.AJKI01000040_gene3189	0.0003154	51.0	COG0515@1|root,COG0515@2|Bacteria,4PMF4@976|Bacteroidetes,2G0DX@200643|Bacteroidia,3XK1J@558415|Marinilabiliaceae	976|Bacteroidetes	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Kdo
DTH2_k127_5829864_4	1227453.C444_03567	7.195e-06	53.0	COG0662@1|root,arCOG03003@2157|Archaea,2XX6B@28890|Euryarchaeota,23WEI@183963|Halobacteria	183963|Halobacteria	G	COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DTH2_k127_5829864_1	479435.Kfla_2951	4.226e-58	214.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4DNXK@85009|Propionibacteriales	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
DTH2_k127_5829864_2	1396141.BATP01000044_gene1504	1.793e-17	89.0	COG1585@1|root,COG1585@2|Bacteria,46XMU@74201|Verrucomicrobia,2IW7N@203494|Verrucomicrobiae	203494|Verrucomicrobiae	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
DTH2_k127_5829864_0	509635.N824_12640	2.809e-94	313.0	COG0330@1|root,COG0330@2|Bacteria,4NEP5@976|Bacteroidetes,1IX6I@117747|Sphingobacteriia	976|Bacteroidetes	O	C-terminal region of band_7	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
DTH2_k127_5862976_2	913865.DOT_5897	1.247e-27	117.0	COG3070@1|root,COG3070@2|Bacteria,1W1DT@1239|Firmicutes,254ET@186801|Clostridia,26614@186807|Peptococcaceae	186801|Clostridia	K	PFAM TfoX N-terminal domain	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
DTH2_k127_5862976_3	1267533.KB906735_gene4811	9.392e-19	100.0	COG1267@1|root,COG1267@2|Bacteria,3Y4T1@57723|Acidobacteria,2JJH6@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Phosphatidylglycerophosphatase A	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
DTH2_k127_5862976_1	339860.Msp_0014	3.735e-40	166.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota,23NY7@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
DTH2_k127_5862976_0	1535422.ND16A_0310	2.848e-68	238.0	COG3325@1|root,COG3325@2|Bacteria	2|Bacteria	G	chitin binding	chiA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18
DTH2_k127_5880716_0	1131462.DCF50_p1172	1.175e-192	615.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia,2612Q@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
DTH2_k127_5880716_4	1499967.BAYZ01000036_gene2414	2.49e-41	157.0	2BK9M@1|root,32EPT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5880716_1	714943.Mucpa_1134	4.204e-173	552.0	2BXG3@1|root,2Z82R@2|Bacteria,4NI3Z@976|Bacteroidetes,1IVY2@117747|Sphingobacteriia	976|Bacteroidetes	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
DTH2_k127_5880716_3	1408424.JHYI01000025_gene1765	6.397e-49	190.0	COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,4HDE3@91061|Bacilli,1ZC4Y@1386|Bacillus	91061|Bacilli	GK	ROK family	xylR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
DTH2_k127_5880716_2	1499967.BAYZ01000076_gene747	9.025e-94	314.0	COG1028@1|root,COG1028@2|Bacteria	1499967.BAYZ01000076_gene747|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5880716_5	927658.AJUM01000022_gene1032	1.249e-10	63.0	COG3875@1|root,COG3875@2|Bacteria,4NI4Z@976|Bacteroidetes,2FQM8@200643|Bacteroidia,3XJV1@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DTH2_k127_5893240_0	794903.OPIT5_10195	2.096e-23	115.0	COG1874@1|root,COG3170@1|root,COG1874@2|Bacteria,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	3.1.3.3,3.2.1.23,3.5.1.28	ko:K01448,ko:K07315,ko:K12308,ko:K21000,ko:K21470	ko00052,ko01503,ko02025,map00052,map01503,map02025	M00727	R01105,R04112	RC00064,RC00141,RC00452	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03021,ko03036	-	GH39	-	Glyco_hydro_42
DTH2_k127_5917704_3	1142394.PSMK_15860	7.075e-17	81.0	COG2804@1|root,COG2804@2|Bacteria,2IXSA@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DTH2_k127_5917704_1	756272.Plabr_2546	3.732e-153	492.0	COG2805@1|root,COG2805@2|Bacteria,2IXRP@203682|Planctomycetes	203682|Planctomycetes	NU	COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DTH2_k127_5917704_0	1142394.PSMK_20220	5e-218	690.0	COG2804@1|root,COG2804@2|Bacteria,2IXGK@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DTH2_k127_5917704_2	595460.RRSWK_04759	7.962e-54	198.0	COG1459@1|root,COG1459@2|Bacteria,2IX2A@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway component PulF	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DTH2_k127_594760_6	748449.Halha_0673	6.567e-13	81.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,3WABD@53433|Halanaerobiales	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
DTH2_k127_594760_3	1298593.TOL_2493	1.929e-62	228.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,1XH8G@135619|Oceanospirillales	135619|Oceanospirillales	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
DTH2_k127_594760_4	1460634.JCM19037_240	2.498e-17	93.0	COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,4HA2E@91061|Bacilli	91061|Bacilli	N	flagellar biosynthetic protein FliR	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
DTH2_k127_594760_5	555778.Hneap_0711	5.864e-16	80.0	COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,1SCBG@1236|Gammaproteobacteria,1WZE5@135613|Chromatiales	135613|Chromatiales	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
DTH2_k127_594760_2	608506.COB47_1938	1.922e-66	235.0	COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,42F2T@68295|Thermoanaerobacterales	186801|Clostridia	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
DTH2_k127_594760_7	666685.R2APBS1_2988	2.556e-06	55.0	COG3190@1|root,COG3190@2|Bacteria,1NHJX@1224|Proteobacteria,1SX47@1236|Gammaproteobacteria,1X88A@135614|Xanthomonadales	135614|Xanthomonadales	N	flagellar	fliO	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
DTH2_k127_594760_0	526222.Desal_1351	5.425e-102	344.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2M7WH@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
DTH2_k127_594760_1	553177.CAPSP0001_2802	1.435e-81	274.0	28HAW@1|root,2Z7N4@2|Bacteria,4NG29@976|Bacteroidetes,1I73Y@117743|Flavobacteriia,1ERDG@1016|Capnocytophaga	976|Bacteroidetes	S	KilA-N	-	-	-	-	-	-	-	-	-	-	-	-	KilA-N
DTH2_k127_59503_0	1499967.BAYZ01000118_gene3258	7.446e-175	558.0	COG1541@1|root,COG1541@2|Bacteria,2NREC@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
DTH2_k127_5958061_0	1116375.VEJY3_10015	9.683e-154	496.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,1XTX4@135623|Vibrionales	135623|Vibrionales	E	COG1448 Aspartate tyrosine aromatic aminotransferase	aspC	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH2_k127_5958061_4	243231.GSU2429	4.797e-51	196.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RVN@68525|delta/epsilon subdivisions,2WNJW@28221|Deltaproteobacteria,43SP4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	SurA N-terminal domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
DTH2_k127_5958061_5	247490.KSU1_D0285	6.287e-41	160.0	2CA4A@1|root,32RQK@2|Bacteria,2J0BM@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
DTH2_k127_5958061_3	886293.Sinac_1305	2.747e-66	239.0	COG0472@1|root,COG0472@2|Bacteria,2IXB8@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
DTH2_k127_5958061_6	314230.DSM3645_16310	8.005e-20	105.0	COG3307@1|root,COG3307@2|Bacteria,2IZXM@203682|Planctomycetes	203682|Planctomycetes	M	PFAM O-Antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
DTH2_k127_5958061_1	1142394.PSMK_13860	8.597e-147	475.0	COG0195@1|root,COG0195@2|Bacteria,2IWY3@203682|Planctomycetes	203682|Planctomycetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
DTH2_k127_5958061_2	1304880.JAGB01000001_gene234	5.519e-106	368.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
DTH2_k127_5969340_8	1094980.Mpsy_0782	1.365e-12	70.0	COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,2N9K8@224756|Methanomicrobia	224756|Methanomicrobia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DTH2_k127_5969340_0	448385.sce3867	1.949e-82	282.0	COG2908@1|root,COG2908@2|Bacteria,1QN5G@1224|Proteobacteria,43A37@68525|delta/epsilon subdivisions,2WYE3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DTH2_k127_5969340_5	1224318.DT73_00085	2.992e-22	109.0	2DBFB@1|root,2Z8XA@2|Bacteria,1MVTN@1224|Proteobacteria,1RM97@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4056)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4056
DTH2_k127_5969340_3	123214.PERMA_1471	3.409e-46	180.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
DTH2_k127_5969340_7	237368.SCABRO_00475	1.553e-18	91.0	2DVHI@1|root,32UZG@2|Bacteria,2J0QY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
DTH2_k127_5969340_2	756272.Plabr_2024	7.293e-61	223.0	COG0299@1|root,COG0299@2|Bacteria,2IZ96@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
DTH2_k127_5969340_4	404589.Anae109_0764	6.33e-32	138.0	COG0328@1|root,COG0328@2|Bacteria,1MZD1@1224|Proteobacteria,42UI6@68525|delta/epsilon subdivisions,2WQSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Ribonuclease H	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
DTH2_k127_5969340_6	1142394.PSMK_06010	2.689e-21	104.0	COG1579@1|root,COG1579@2|Bacteria	2|Bacteria	-	-	CP_0228	-	3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	zf-RING_7
DTH2_k127_5969340_1	237368.SCABRO_03442	1.627e-68	243.0	COG0046@1|root,COG0046@2|Bacteria,2IXRT@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
DTH2_k127_5984469_5	697281.Mahau_0436	7.509e-09	60.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,24JE8@186801|Clostridia,42G0X@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
DTH2_k127_5984469_4	396588.Tgr7_0831	2.525e-11	68.0	COG0720@1|root,COG0720@2|Bacteria,1PNDM@1224|Proteobacteria,1S7ZW@1236|Gammaproteobacteria,1WZ30@135613|Chromatiales	135613|Chromatiales	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
DTH2_k127_5984469_0	575540.Isop_1187	1.525e-108	362.0	COG0825@1|root,COG0825@2|Bacteria,2IX7N@203682|Planctomycetes	203682|Planctomycetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
DTH2_k127_5984469_1	404380.Gbem_3259	1.958e-50	190.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,42MH0@68525|delta/epsilon subdivisions,2WRNN@28221|Deltaproteobacteria,43TA8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
DTH2_k127_5984469_3	398527.Bphyt_2105	2.672e-12	78.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,1K69W@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DTH2_k127_5984469_2	666510.ASAC_1243	9.917e-36	141.0	COG0413@1|root,arCOG00584@2157|Archaea,2XPQ2@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
DTH2_k127_5989186_1	1163617.SCD_n01375	2.355e-34	132.0	2DBSM@1|root,32TY0@2|Bacteria,1N5UN@1224|Proteobacteria,2VV1Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
DTH2_k127_5989186_0	330214.NIDE0057	7.225e-108	364.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
DTH2_k127_5989186_2	204773.HEAR1190	2.489e-31	129.0	COG3794@1|root,COG3794@2|Bacteria,1MZWU@1224|Proteobacteria,2VV7G@28216|Betaproteobacteria,47765@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
DTH2_k127_5990043_3	1288963.ADIS_1567	6.189e-89	302.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47K1Z@768503|Cytophagia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
DTH2_k127_5990043_4	909663.KI867150_gene2329	4.803e-75	259.0	COG0300@1|root,COG0300@2|Bacteria,1P42K@1224|Proteobacteria,42PPU@68525|delta/epsilon subdivisions,2WM15@28221|Deltaproteobacteria,2MQSQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DTH2_k127_5990043_6	1142394.PSMK_22590	1.213e-61	238.0	COG1639@1|root,COG4191@1|root,COG1639@2|Bacteria,COG4191@2|Bacteria,2J037@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HDOD,HisKA
DTH2_k127_5990043_5	521674.Plim_2544	1.098e-66	232.0	COG0745@1|root,COG0745@2|Bacteria,2IY82@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
DTH2_k127_5990043_0	945713.IALB_2034	3.989e-157	511.0	COG0733@1|root,COG0733@2|Bacteria	2|Bacteria	S	neurotransmitter:sodium symporter activity	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
DTH2_k127_5990043_8	1142394.PSMK_31090	2.173e-44	171.0	COG2159@1|root,COG2159@2|Bacteria,2IXTD@203682|Planctomycetes	203682|Planctomycetes	S	TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DTH2_k127_5990043_1	1462526.BN990_02623	3.74e-141	459.0	COG1301@1|root,COG1301@2|Bacteria,1TQ3F@1239|Firmicutes,4HBZM@91061|Bacilli,4C5ER@84406|Virgibacillus	91061|Bacilli	U	Sodium:dicarboxylate symporter family	gltT	-	-	-	-	-	-	-	-	-	-	-	SDF
DTH2_k127_5990043_2	1151292.QEW_1361	3.361e-120	398.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
DTH2_k127_5990043_7	648996.Theam_1308	2.876e-45	167.0	COG0432@1|root,COG0432@2|Bacteria,2G41G@200783|Aquificae	200783|Aquificae	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
DTH2_k127_6024029_6	314230.DSM3645_08617	3.917e-54	203.0	COG0009@1|root,COG0394@1|root,COG0009@2|Bacteria,COG0394@2|Bacteria,2IX5F@203682|Planctomycetes	203682|Planctomycetes	T	Belongs to the SUA5 family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc,Sua5_yciO_yrdC
DTH2_k127_6024029_5	882.DVU_2548	3.991e-62	220.0	COG1182@1|root,COG1182@2|Bacteria,1NJP3@1224|Proteobacteria,42UST@68525|delta/epsilon subdivisions,2WR0H@28221|Deltaproteobacteria,2MBN8@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
DTH2_k127_6024029_7	443144.GM21_1179	8.57e-37	148.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,43UMI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH2_k127_6024029_2	247490.KSU1_B0010	3.498e-89	317.0	COG0358@1|root,COG0358@2|Bacteria,2IXQ4@203682|Planctomycetes	203682|Planctomycetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
DTH2_k127_6024029_0	886293.Sinac_1564	6.311e-202	645.0	COG0568@1|root,COG0568@2|Bacteria,2IXI3@203682|Planctomycetes	203682|Planctomycetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
DTH2_k127_6024029_4	1121459.AQXE01000001_gene2816	2.189e-78	273.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2WJPP@28221|Deltaproteobacteria,2M8KS@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
DTH2_k127_6024029_1	742767.HMPREF9456_01720	1.055e-142	477.0	COG1208@1|root,COG1208@2|Bacteria,4NGYR@976|Bacteroidetes,2FMJ4@200643|Bacteroidia,23220@171551|Porphyromonadaceae	976|Bacteroidetes	JM	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
DTH2_k127_6024029_8	926569.ANT_26890	3.127e-19	96.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	2|Bacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
DTH2_k127_6024029_3	237368.SCABRO_01704	9.327e-89	302.0	COG0042@1|root,COG0042@2|Bacteria,2IYH0@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
DTH2_k127_6043390_4	1408473.JHXO01000001_gene2487	6.033e-145	468.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,2FQ0Q@200643|Bacteroidia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_6043390_10	1396141.BATP01000002_gene4837	1.083e-63	229.0	COG3828@1|root,COG3828@2|Bacteria,46V1D@74201|Verrucomicrobia,2IUS0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
DTH2_k127_6043390_5	575540.Isop_1330	5.946e-142	457.0	COG1082@1|root,COG1082@2|Bacteria,2IXXS@203682|Planctomycetes	203682|Planctomycetes	G	PFAM AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
DTH2_k127_6043390_3	518766.Rmar_1734	1.854e-157	505.0	COG0673@1|root,COG0673@2|Bacteria,4NFMS@976|Bacteroidetes,1FJ32@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DTH2_k127_6043390_7	1121924.ATWH01000005_gene2571	1.32e-82	286.0	COG2207@1|root,COG2207@2|Bacteria,2GYST@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
DTH2_k127_6043390_14	1499967.BAYZ01000059_gene4769	2.57e-34	135.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
DTH2_k127_6043390_12	1499967.BAYZ01000059_gene4771	5.084e-55	197.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
DTH2_k127_6043390_2	903818.KI912269_gene60	4.25e-216	685.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3,Pyr_redox_2
DTH2_k127_6043390_0	857293.CAAU_0207	1.764e-254	797.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36EMP@31979|Clostridiaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DTH2_k127_6043390_13	1499967.BAYZ01000059_gene4773	4.846e-42	156.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K17992	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
DTH2_k127_6043390_6	1499967.BAYZ01000059_gene4782	1.177e-94	333.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HAMP,HATPase_c,HisKA,PAS,dCache_3
DTH2_k127_6043390_11	1289135.A966_01140	4.334e-63	223.0	COG2344@1|root,COG2344@2|Bacteria,2J89C@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
DTH2_k127_6043390_8	1121447.JONL01000009_gene2565	9.831e-71	253.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2MAEP@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	CarS-like,Metallophos
DTH2_k127_6043390_1	1142394.PSMK_27420	4.438e-218	692.0	COG0504@1|root,COG0504@2|Bacteria,2IXNE@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
DTH2_k127_6043390_9	1123508.JH636439_gene1482	6.728e-69	241.0	COG1212@1|root,COG1212@2|Bacteria,2IYWF@203682|Planctomycetes	203682|Planctomycetes	H	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
DTH2_k127_6095711_1	518766.Rmar_0472	3.906e-66	229.0	COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,1FIXF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Transketolase, thiamine diphosphate binding domain	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
DTH2_k127_6095711_0	1142394.PSMK_11030	7.441e-146	477.0	COG0285@1|root,COG0285@2|Bacteria,2IX24@203682|Planctomycetes	203682|Planctomycetes	H	folylpolyglutamate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
DTH2_k127_6095711_3	644282.Deba_1149	2.105e-07	62.0	2BCS0@1|root,303C3@2|Bacteria,1N7SU@1224|Proteobacteria,42WF2@68525|delta/epsilon subdivisions,2WR6I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
DTH2_k127_6095711_2	1379698.RBG1_1C00001G0415	1.249e-44	169.0	COG5316@1|root,COG5316@2|Bacteria,2NPBR@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
DTH2_k127_6135691_1	1196323.ALKF01000190_gene5488	4.008e-51	185.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
DTH2_k127_6135691_2	1267535.KB906767_gene241	4.983e-33	148.0	COG3345@1|root,COG3345@2|Bacteria,3Y3UB@57723|Acidobacteria,2JKQN@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Glycoside hydrolase, clan GH-D	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
DTH2_k127_6135691_0	247490.KSU1_D0781	2.307e-63	235.0	COG0534@1|root,COG0534@2|Bacteria,2IXGS@203682|Planctomycetes	203682|Planctomycetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
DTH2_k127_6173171_6	237368.SCABRO_00441	2.44e-152	492.0	COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes	203682|Planctomycetes	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
DTH2_k127_6173171_12	264462.Bd1397	8.977e-26	111.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2MU6W@213481|Bdellovibrionales,2WQKU@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	PFAM RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
DTH2_k127_6173171_10	1304885.AUEY01000030_gene2416	5.562e-38	152.0	COG1215@1|root,COG1215@2|Bacteria,1RJNP@1224|Proteobacteria,42ST7@68525|delta/epsilon subdivisions,2X7KP@28221|Deltaproteobacteria,2MPM9@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH2_k127_6173171_9	1499967.BAYZ01000163_gene6589	7.562e-43	161.0	COG2731@1|root,COG2731@2|Bacteria	2|Bacteria	G	single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
DTH2_k127_6173171_0	452637.Oter_1671	1.166e-208	666.0	COG0591@1|root,COG0591@2|Bacteria,46S93@74201|Verrucomicrobia,3K7R7@414999|Opitutae	414999|Opitutae	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DTH2_k127_6173171_13	452637.Oter_1672	7.154e-10	62.0	2C74X@1|root,3304C@2|Bacteria,46WSF@74201|Verrucomicrobia,3K8CV@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6173171_3	81824.XP_001749217.1	4.394e-157	505.0	COG0153@1|root,COG1095@1|root,KOG0631@2759|Eukaryota,KOG3297@2759|Eukaryota,397U9@33154|Opisthokonta	33154|Opisthokonta	K	transcription initiation from RNA polymerase III promoter	POLR3H	GO:0000228,GO:0000428,GO:0000785,GO:0000790,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005666,GO:0005694,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0006139,GO:0006351,GO:0006352,GO:0006383,GO:0006384,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009304,GO:0009987,GO:0010467,GO:0015630,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042797,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0046483,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0098781,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	-	ko:K03022	ko00230,ko00240,ko01100,ko03020,ko04623,ko05169,map00230,map00240,map01100,map03020,map04623,map05169	M00181	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021	-	-	-	RNA_pol_Rbc25,SHS2_Rpb7-N
DTH2_k127_6173171_2	1242864.D187_004920	2.416e-165	534.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
DTH2_k127_6173171_11	644282.Deba_1149	8.795e-35	144.0	2BCS0@1|root,303C3@2|Bacteria,1N7SU@1224|Proteobacteria,42WF2@68525|delta/epsilon subdivisions,2WR6I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
DTH2_k127_6173171_5	696369.KI912183_gene2745	2.197e-152	494.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2603A@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DTH2_k127_6173171_8	56780.SYN_02212	6.37e-44	162.0	COG0347@1|root,COG0347@2|Bacteria,1RKRK@1224|Proteobacteria,42T3E@68525|delta/epsilon subdivisions,2WPAT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
DTH2_k127_6173171_4	443144.GM21_1136	2.824e-154	498.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42ZDZ@68525|delta/epsilon subdivisions,2WTXC@28221|Deltaproteobacteria,43TRQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	PFAM Rh family protein ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DTH2_k127_6173171_7	1195236.CTER_0200	3.835e-45	165.0	COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia	186801|Clostridia	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
DTH2_k127_6173171_1	1449126.JQKL01000047_gene2724	7.057e-192	606.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,26A0R@186813|unclassified Clostridiales	186801|Clostridia	S	Glutamine synthetase type III N terminal	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
DTH2_k127_6184068_3	1121017.AUFG01000030_gene480	3.714e-15	80.0	COG2223@1|root,COG2223@2|Bacteria,2I2RR@201174|Actinobacteria,4FF4S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
DTH2_k127_6184068_2	311424.DhcVS_119	1.359e-34	138.0	COG0680@1|root,COG0680@2|Bacteria,2G7BV@200795|Chloroflexi,34D7G@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
DTH2_k127_6184068_0	1089553.Tph_c06360	3.731e-155	503.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,42FVY@68295|Thermoanaerobacterales	186801|Clostridia	C	hydrogenase large subunit	-	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
DTH2_k127_6184068_1	1487923.DP73_17860	4.917e-67	241.0	COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,261I4@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
DTH2_k127_6222193_6	1303518.CCALI_01733	1.549e-23	100.0	COG0780@1|root,COG0780@2|Bacteria	2|Bacteria	G	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
DTH2_k127_6222193_1	1122137.AQXF01000006_gene803	5.052e-101	334.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
DTH2_k127_6222193_3	314230.DSM3645_26976	1.353e-64	229.0	COG0571@1|root,COG0571@2|Bacteria,2IYW1@203682|Planctomycetes	203682|Planctomycetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
DTH2_k127_6222193_4	1123242.JH636436_gene468	2.966e-62	226.0	COG1181@1|root,COG1181@2|Bacteria,2IZHT@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
DTH2_k127_6222193_2	521674.Plim_0011	1.961e-89	303.0	COG0812@1|root,COG0812@2|Bacteria,2IYGQ@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
DTH2_k127_6222193_0	247490.KSU1_D0406	2.191e-112	378.0	COG0773@1|root,COG0773@2|Bacteria,2IYEH@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DTH2_k127_6222193_5	756272.Plabr_1727	2.23e-36	144.0	COG1943@1|root,COG1943@2|Bacteria,2J110@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
DTH2_k127_6223325_1	1122179.KB890441_gene1057	1.862e-35	140.0	COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1IW3G@117747|Sphingobacteriia	976|Bacteroidetes	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
DTH2_k127_6223325_0	1303518.CCALI_01571	3.349e-137	445.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	He_PIG,He_PIG_assoc,Melibiase_2,Melibiase_2_C,NPCBM
DTH2_k127_6233839_1	909663.KI867150_gene1960	1.258e-16	84.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,42MJW@68525|delta/epsilon subdivisions,2WMYI@28221|Deltaproteobacteria,2MRXN@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Flagellar L-ring protein	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
DTH2_k127_6233839_0	933262.AXAM01000005_gene2494	2.009e-72	258.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2WK22@28221|Deltaproteobacteria,2MI2Y@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
DTH2_k127_6233839_2	1123279.ATUS01000003_gene437	0.00014	49.0	COG3951@1|root,COG3951@2|Bacteria,1QUV5@1224|Proteobacteria,1T224@1236|Gammaproteobacteria,1JC3M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Rod binding protein	-	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Rod-binding
DTH2_k127_6244408_0	269799.Gmet_1338	7.716e-171	560.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
DTH2_k127_6244408_3	1210884.HG799462_gene7971	3.547e-08	66.0	2CFWI@1|root,32S2N@2|Bacteria,2J08K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6244408_2	1121904.ARBP01000010_gene2270	8.705e-12	73.0	2BXUX@1|root,32R23@2|Bacteria,4NR4Y@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6244408_1	706587.Desti_3650	2.613e-150	484.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WJ4H@28221|Deltaproteobacteria,2MQ47@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	AAA_26,Aminotran_3
DTH2_k127_6248857_1	1123400.KB904769_gene2865	2.548e-50	182.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1RPXT@1236|Gammaproteobacteria,463J2@72273|Thiotrichales	72273|Thiotrichales	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6248857_2	227377.CBU_1294	2.476e-38	146.0	COG1487@1|root,COG1487@2|Bacteria,1N44Q@1224|Proteobacteria,1SD4I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
DTH2_k127_6248857_4	237368.SCABRO_00407	2.63e-09	61.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
DTH2_k127_6248857_0	1499967.BAYZ01000151_gene1675	1.027e-58	213.0	COG1355@1|root,COG1355@2|Bacteria,2NQ00@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
DTH2_k127_6299742_0	251229.Chro_3920	8.752e-132	428.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G5KH@1117|Cyanobacteria	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_33
DTH2_k127_6339212_4	1142394.PSMK_31720	1.968e-31	136.0	COG0705@1|root,COG0705@2|Bacteria,2IZZY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
DTH2_k127_6339212_0	765952.PUV_24050	1.904e-142	462.0	COG1373@1|root,COG1373@2|Bacteria,2JH0R@204428|Chlamydiae	204428|Chlamydiae	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	DUF4143
DTH2_k127_6339212_2	1142394.PSMK_00010	3.872e-102	349.0	COG0593@1|root,COG0593@2|Bacteria,2IWXU@203682|Planctomycetes	203682|Planctomycetes	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
DTH2_k127_6339212_1	1142394.PSMK_00390	2.985e-106	352.0	COG0552@1|root,COG0552@2|Bacteria,2IXAG@203682|Planctomycetes	203682|Planctomycetes	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
DTH2_k127_6339212_3	1304888.ATWF01000002_gene77	4.185e-74	258.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K06219	-	-	-	-	ko00000	-	-	-	Glycos_transf_1,Glycos_transf_2,MethyTransf_Reg,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_2
DTH2_k127_6340736_4	1121451.DESAM_20551	3.51e-11	68.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2M7YN@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
DTH2_k127_6340736_2	56110.Oscil6304_1061	3.039e-29	121.0	COG0736@1|root,COG0736@2|Bacteria,1G6YV@1117|Cyanobacteria,1HFS0@1150|Oscillatoriales	1117|Cyanobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
DTH2_k127_6340736_0	756272.Plabr_3360	1.083e-204	654.0	COG0445@1|root,COG0445@2|Bacteria,2IXGA@203682|Planctomycetes	203682|Planctomycetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
DTH2_k127_6340736_1	643562.Daes_1109	4.889e-50	187.0	COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,42MX8@68525|delta/epsilon subdivisions,2WKE1@28221|Deltaproteobacteria,2M9GW@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fliC	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
DTH2_k127_6340736_3	335543.Sfum_0873	6.83e-16	81.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,HEAT_2
DTH2_k127_634276_2	716544.wcw_1068	1.171e-60	214.0	COG0652@1|root,COG0652@2|Bacteria,2JG2B@204428|Chlamydiae	204428|Chlamydiae	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
DTH2_k127_634276_1	880073.Calab_3771	8.812e-98	330.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
DTH2_k127_634276_0	344747.PM8797T_04585	3.334e-110	370.0	COG4927@1|root,COG4927@2|Bacteria,2IYD9@203682|Planctomycetes	203682|Planctomycetes	M	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
DTH2_k127_6351805_0	1142394.PSMK_11990	2.531e-124	407.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2IWZ7@203682|Planctomycetes	203682|Planctomycetes	E	chorismate mutase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
DTH2_k127_6351805_1	243090.RB7095	1.269e-85	290.0	COG0149@1|root,COG0149@2|Bacteria,2IXV9@203682|Planctomycetes	203682|Planctomycetes	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
DTH2_k127_6351805_7	521674.Plim_2050	2.489e-07	58.0	COG1314@1|root,COG1314@2|Bacteria,2J0NU@203682|Planctomycetes	203682|Planctomycetes	U	PFAM Preprotein translocase SecG subunit	-	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
DTH2_k127_6351805_2	756272.Plabr_4358	6.015e-53	198.0	COG1561@1|root,COG1561@2|Bacteria,2IYZH@203682|Planctomycetes	203682|Planctomycetes	S	stress-induced protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
DTH2_k127_6351805_3	536227.CcarbDRAFT_2590	7.399e-52	189.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,36EVE@31979|Clostridiaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
DTH2_k127_6351805_6	1123242.JH636434_gene5388	5.512e-13	71.0	COG1758@1|root,COG1758@2|Bacteria,2J0KS@203682|Planctomycetes	203682|Planctomycetes	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
DTH2_k127_6351805_4	153948.NAL212_1453	2.071e-47	176.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,3723U@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
DTH2_k127_6351805_5	706433.HMPREF9430_01304	4.337e-42	161.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,3VP0U@526524|Erysipelotrichia	526524|Erysipelotrichia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36	ko:K01598	ko00770,ko01100,map00770,map01100	M00120	R03269	RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
DTH2_k127_6372678_4	595460.RRSWK_02934	2.261e-69	244.0	COG0767@1|root,COG0767@2|Bacteria,2IX01@203682|Planctomycetes	203682|Planctomycetes	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
DTH2_k127_6372678_3	335543.Sfum_2449	5.751e-71	249.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2MQE7@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
DTH2_k127_6372678_12	1144275.COCOR_06198	1.179e-05	55.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Excalibur,Lactamase_B
DTH2_k127_6372678_10	1123518.ARWI01000001_gene1155	2.694e-09	66.0	COG1525@1|root,COG1525@2|Bacteria,1N0I9@1224|Proteobacteria,1S8DU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	SNase
DTH2_k127_6372678_9	452637.Oter_2186	7.476e-32	129.0	2EHW5@1|root,33BMQ@2|Bacteria,46WAC@74201|Verrucomicrobia,3K9R0@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6372678_11	1541065.JRFE01000006_gene4834	2.306e-07	63.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	ygaP	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016740,GO:0016782,GO:0016783,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2892,Rhodanese
DTH2_k127_6372678_7	1454004.AW11_03550	3.164e-51	198.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,1KQWP@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
DTH2_k127_6372678_5	1121403.AUCV01000059_gene3333	1.244e-66	235.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2MJPN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
DTH2_k127_6372678_0	530564.Psta_4054	1.605e-124	407.0	COG2876@1|root,COG2876@2|Bacteria,2IWU9@203682|Planctomycetes	203682|Planctomycetes	E	phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
DTH2_k127_6372678_8	1304885.AUEY01000004_gene975	5.22e-43	165.0	COG2129@1|root,COG2129@2|Bacteria,1RJJX@1224|Proteobacteria,42T2C@68525|delta/epsilon subdivisions,2WP7Q@28221|Deltaproteobacteria,2MQ17@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos
DTH2_k127_6372678_6	1142394.PSMK_18100	1.183e-62	221.0	COG0740@1|root,COG0740@2|Bacteria,2IYFK@203682|Planctomycetes	203682|Planctomycetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
DTH2_k127_6372678_2	1142394.PSMK_28460	3.172e-85	286.0	COG0740@1|root,COG0740@2|Bacteria,2IXQN@203682|Planctomycetes	203682|Planctomycetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
DTH2_k127_6372678_1	886293.Sinac_6978	2.391e-107	357.0	COG0488@1|root,COG0488@2|Bacteria,2IX59@203682|Planctomycetes	203682|Planctomycetes	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DTH2_k127_639724_3	1125863.JAFN01000001_gene353	7.618e-133	432.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
DTH2_k127_639724_2	338963.Pcar_1613	7.698e-146	471.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,43SCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
DTH2_k127_639724_7	103690.17130088	2.28e-09	68.0	COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1G1FY@1117|Cyanobacteria,1HKTP@1161|Nostocales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	cyaD	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,GAF_2,Guanylate_cyc
DTH2_k127_639724_6	485918.Cpin_1202	2.927e-38	156.0	COG0564@1|root,COG0564@2|Bacteria,4NHKH@976|Bacteroidetes,1IQTT@117747|Sphingobacteriia	976|Bacteroidetes	J	Pseudouridine synthase	-	-	5.4.99.23,5.4.99.24	ko:K06179,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
DTH2_k127_639724_0	1195236.CTER_2499	3.196e-283	892.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia,3WHH3@541000|Ruminococcaceae	186801|Clostridia	G	PFAM Glycosyl hydrolases family 38 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
DTH2_k127_639724_1	1123371.ATXH01000033_gene422	2.841e-146	474.0	COG0151@1|root,COG0151@2|Bacteria,2GGTX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
DTH2_k127_639724_4	926569.ANT_00560	2.477e-121	395.0	COG0428@1|root,COG0428@2|Bacteria,2G671@200795|Chloroflexi	200795|Chloroflexi	P	ZIP Zinc transporter	-	-	-	ko:K07238,ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11,2.A.5.5	-	-	Zip
DTH2_k127_639724_5	521674.Plim_2449	1.699e-47	180.0	COG0557@1|root,COG0557@2|Bacteria,2IX1J@203682|Planctomycetes	203682|Planctomycetes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
DTH2_k127_6413726_1	1142394.PSMK_29780	9.551e-61	220.0	COG0515@1|root,COG0515@2|Bacteria,2IZHV@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
DTH2_k127_6413726_2	1142394.PSMK_24810	1.481e-56	207.0	COG0639@1|root,COG0639@2|Bacteria,2IZ5T@203682|Planctomycetes	203682|Planctomycetes	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DTH2_k127_6413726_3	1142394.PSMK_08290	1.315e-40	163.0	COG2199@1|root,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	yeaP	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K13069	-	-	R08057	-	ko00000,ko01000	-	-	-	GAF,GAF_2,GAF_3,GGDEF
DTH2_k127_6413726_0	221109.22777767	2.321e-97	326.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,4HCJE@91061|Bacilli,23NBV@182709|Oceanobacillus	91061|Bacilli	M	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
DTH2_k127_6417167_8	857293.CAAU_1542	4.773e-14	76.0	COG0340@1|root,COG0340@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,36F7S@31979|Clostridiaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
DTH2_k127_6417167_3	1123508.JH636439_gene650	2.473e-63	228.0	COG0157@1|root,COG0157@2|Bacteria,2IYVV@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
DTH2_k127_6417167_1	247490.KSU1_C0303	3.675e-107	363.0	COG0141@1|root,COG0141@2|Bacteria,2IXQ3@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
DTH2_k127_6417167_5	945713.IALB_2664	3.12e-30	127.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
DTH2_k127_6417167_0	694431.DESACE_00450	1.231e-242	766.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,2M6MV@213113|Desulfurellales	28221|Deltaproteobacteria	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
DTH2_k127_6417167_2	373903.Hore_21530	2.016e-73	262.0	COG1482@1|root,COG1482@2|Bacteria,1V0PH@1239|Firmicutes,2487K@186801|Clostridia,3WAJW@53433|Halanaerobiales	186801|Clostridia	G	TIGRFAM mannose-6-phosphate isomerase, class I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS19425	PMI_typeI
DTH2_k127_6417167_7	314230.DSM3645_15950	3.819e-21	100.0	2B8BF@1|root,321K5@2|Bacteria,2IZTE@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF2617	-	-	-	-	-	-	-	-	-	-	-	-	DUF2617
DTH2_k127_6417167_6	530564.Psta_2461	1.03e-27	125.0	COG1266@1|root,COG1266@2|Bacteria,2J06D@203682|Planctomycetes	203682|Planctomycetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DTH2_k127_6417167_4	237368.SCABRO_01614	9.702e-45	165.0	COG2231@1|root,COG2231@2|Bacteria,2IZ9A@203682|Planctomycetes	203682|Planctomycetes	L	endonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
DTH2_k127_6433639_1	1121459.AQXE01000003_gene1144	2.603e-30	141.0	COG0834@1|root,COG3852@1|root,COG0834@2|Bacteria,COG3852@2|Bacteria,1N315@1224|Proteobacteria,43CSY@68525|delta/epsilon subdivisions,2X80H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial periplasmic substrate-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg,SBP_bac_3
DTH2_k127_6433639_0	1121403.AUCV01000030_gene2800	4.854e-53	215.0	COG2202@1|root,COG2202@2|Bacteria,1NWNJ@1224|Proteobacteria,42NXV@68525|delta/epsilon subdivisions,2WUGY@28221|Deltaproteobacteria,2MPMJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	-
DTH2_k127_6455009_0	1297570.MESS4_670033	0.0	1310.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,43K0Q@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
DTH2_k127_6455009_2	522306.CAP2UW1_1267	1.622e-23	106.0	2EBP0@1|root,335P6@2|Bacteria,1N33Y@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6455009_1	1294143.H681_14790	1.552e-113	380.0	COG2067@1|root,COG2067@2|Bacteria,1R3SS@1224|Proteobacteria,1S0X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
DTH2_k127_6455009_3	1211579.PP4_25170	3.734e-08	62.0	2DN52@1|root,32VJD@2|Bacteria,1N1NP@1224|Proteobacteria,1T64Y@1236|Gammaproteobacteria,1YY80@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
DTH2_k127_6480985_0	697281.Mahau_2278	6.478e-252	794.0	COG1874@1|root,COG1874@2|Bacteria,1TT9J@1239|Firmicutes,24CY9@186801|Clostridia,42HX5@68295|Thermoanaerobacterales	186801|Clostridia	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
DTH2_k127_6481739_0	765911.Thivi_0693	8.23e-220	704.0	COG0784@1|root,COG2198@1|root,COG4564@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG4564@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1X2V3@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DTH2_k127_6516381_10	452637.Oter_1333	6.516e-07	51.0	2EK70@1|root,33DXD@2|Bacteria,46WTF@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6516381_8	645991.Sgly_3171	1.592e-32	132.0	COG2941@1|root,COG2941@2|Bacteria,1W24D@1239|Firmicutes,25602@186801|Clostridia,2668T@186807|Peptococcaceae	186801|Clostridia	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	-	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	-
DTH2_k127_6516381_9	879212.DespoDRAFT_00200	9.202e-30	124.0	COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria,2MK6D@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
DTH2_k127_6516381_7	935836.JAEL01000057_gene1241	5.006e-54	196.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,4HHRQ@91061|Bacilli,1ZC72@1386|Bacillus	91061|Bacilli	S	COG0491 Zn-dependent hydrolases, including glyoxylases	yqgX	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
DTH2_k127_6516381_1	485915.Dret_2373	6.675e-178	584.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42PCY@68525|delta/epsilon subdivisions,2WJCR@28221|Deltaproteobacteria,2M8HZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	SMART chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K13487	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Cache_3-Cache_2,HAMP,MCPsignal
DTH2_k127_6516381_0	237368.SCABRO_02572	8.906e-200	635.0	COG0119@1|root,COG0119@2|Bacteria,2IXBC@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DTH2_k127_6516381_5	667014.Thein_1148	1.004e-62	222.0	COG2518@1|root,COG2518@2|Bacteria,2GH2E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
DTH2_k127_6516381_2	1121456.ATVA01000019_gene1315	6.661e-128	425.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42Q7W@68525|delta/epsilon subdivisions,2WKZ8@28221|Deltaproteobacteria,2MGZY@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.212	ko:K00752,ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.10,4.D.1.1.2,4.D.1.1.3,4.D.1.1.4,4.D.1.1.5	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
DTH2_k127_6516381_3	289377.HL41_02435	4.946e-111	366.0	COG0152@1|root,COG0152@2|Bacteria,2GH07@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
DTH2_k127_6516381_4	335543.Sfum_3281	3.881e-70	246.0	COG1119@1|root,COG1119@2|Bacteria,1MVVM@1224|Proteobacteria,42RN3@68525|delta/epsilon subdivisions,2X6YZ@28221|Deltaproteobacteria,2MS5N@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.34	ko:K02013,ko:K05776	ko02010,map02010	M00189,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
DTH2_k127_6516381_12	1034345.CAEM01000030_gene958	2.312e-06	59.0	COG0477@1|root,COG2814@2|Bacteria,2H2CQ@201174|Actinobacteria,4CWYU@84998|Coriobacteriia	84998|Coriobacteriia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH2_k127_6516381_11	679897.HMU11890	1.784e-06	58.0	COG1387@1|root,COG1387@2|Bacteria,1RCEG@1224|Proteobacteria,42MIM@68525|delta/epsilon subdivisions,2YMFF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	histidinol phosphate phosphatase	hisJ	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
DTH2_k127_6516381_6	1123242.JH636436_gene86	6.032e-58	211.0	COG0608@1|root,COG0608@2|Bacteria,2IXVB@203682|Planctomycetes	203682|Planctomycetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
DTH2_k127_6520263_9	1120968.AUBX01000012_gene2722	2.108e-27	113.0	COG1004@1|root,COG1004@2|Bacteria,4NE00@976|Bacteroidetes,47KAG@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DTH2_k127_6520263_7	1142394.PSMK_29240	1.335e-29	128.0	COG0720@1|root,COG0720@2|Bacteria	2|Bacteria	H	synthase	ygcM	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
DTH2_k127_6520263_3	530564.Psta_2339	1.302e-72	249.0	COG0302@1|root,COG0302@2|Bacteria,2IYUA@203682|Planctomycetes	203682|Planctomycetes	H	PFAM GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
DTH2_k127_6520263_1	326427.Cagg_1016	2.029e-115	389.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia	32061|Chloroflexia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
DTH2_k127_6520263_0	648996.Theam_0242	3.235e-116	384.0	COG1186@1|root,COG1186@2|Bacteria,2G3P3@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
DTH2_k127_6520263_11	1254432.SCE1572_22340	0.0002017	51.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
DTH2_k127_6520263_6	1142394.PSMK_25540	1.008e-38	153.0	COG0220@1|root,COG0220@2|Bacteria,2IZJM@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
DTH2_k127_6520263_2	401526.TcarDRAFT_2448	9.216e-91	306.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,4H2BS@909932|Negativicutes	909932|Negativicutes	C	Hydrolyase tartrate alpha subunit fumarate domain protein Fe-S type	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
DTH2_k127_6520263_10	1123274.KB899407_gene258	9.296e-12	70.0	29IC7@1|root,3059E@2|Bacteria,2JAQH@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6520263_8	795359.TOPB45_1379	1.735e-27	112.0	2E32K@1|root,32Y2U@2|Bacteria,2GI3B@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6520263_5	439235.Dalk_3938	6.324e-49	180.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42TKH@68525|delta/epsilon subdivisions,2WQBD@28221|Deltaproteobacteria,2MKEM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
DTH2_k127_6520263_4	1499967.BAYZ01000068_gene1940	3.929e-54	198.0	COG0745@1|root,COG0745@2|Bacteria,2NQPY@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DTH2_k127_6523775_1	439235.Dalk_3488	0.0001564	51.0	COG0500@1|root,COG1047@1|root,COG1047@2|Bacteria,COG2226@2|Bacteria,1PCH2@1224|Proteobacteria,42M58@68525|delta/epsilon subdivisions,2WK5Z@28221|Deltaproteobacteria,2MIYH@213118|Desulfobacterales	28221|Deltaproteobacteria	OQ	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DTH2_k127_6533996_0	330214.NIDE0846	2.965e-161	517.0	COG0192@1|root,COG0192@2|Bacteria,3J0A4@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
DTH2_k127_6533996_1	497964.CfE428DRAFT_0914	4.058e-89	299.0	COG0745@1|root,COG0745@2|Bacteria	497964.CfE428DRAFT_0914|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6533996_2	1499967.BAYZ01000167_gene6735	1.375e-07	53.0	COG0454@1|root,COG0456@2|Bacteria,2NS1J@2323|unclassified Bacteria	2|Bacteria	K	FR47-like protein	argO	-	2.3.1.1	ko:K03826,ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
DTH2_k127_6571780_1	335543.Sfum_2866	1.794e-132	437.0	COG2204@1|root,COG2204@2|Bacteria,1QYWF@1224|Proteobacteria,43CD6@68525|delta/epsilon subdivisions,2X7P0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
DTH2_k127_6571780_0	575540.Isop_2818	0.0	1017.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2IX63@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DTH2_k127_657598_1	335543.Sfum_0673	9.981e-158	505.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,2MRGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
DTH2_k127_657598_3	362418.IW19_22340	3.713e-49	186.0	2C3WA@1|root,2Z8P1@2|Bacteria,4NW8R@976|Bacteroidetes,1IADF@117743|Flavobacteriia,2NX79@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_657598_4	1356852.N008_09925	9.995e-05	51.0	2C852@1|root,32YB2@2|Bacteria,4NM63@976|Bacteroidetes,47SHZ@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
DTH2_k127_657598_0	452637.Oter_0554	2.441e-186	592.0	COG1236@1|root,COG1236@2|Bacteria,46UFS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
DTH2_k127_657598_2	530564.Psta_2284	6.548e-106	351.0	COG1611@1|root,COG1611@2|Bacteria,2IZCH@203682|Planctomycetes	203682|Planctomycetes	NOU	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
DTH2_k127_657598_5	395494.Galf_1753	0.0007747	43.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,44VU4@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
DTH2_k127_6589432_0	335543.Sfum_1921	3.65e-144	464.0	COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,42MVP@68525|delta/epsilon subdivisions,2WITG@28221|Deltaproteobacteria,2MQZZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N,Orn_DAP_Arg_deC
DTH2_k127_6589432_1	1437425.CSEC_1519	7.431e-70	241.0	COG4760@1|root,COG4760@2|Bacteria,2JFEY@204428|Chlamydiae	204428|Chlamydiae	S	Bax inhibitor 1 like	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
DTH2_k127_6599050_1	933262.AXAM01000017_gene3132	2.324e-14	84.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,2MI3T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
DTH2_k127_6599050_0	1089548.KI783301_gene3209	1.601e-135	444.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H9Y4@91061|Bacilli,3WDW8@539002|Bacillales incertae sedis	91061|Bacilli	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
DTH2_k127_6602393_10	521674.Plim_2857	8.745e-09	57.0	COG0673@1|root,COG0673@2|Bacteria,2IX6I@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_6602393_6	880070.Cycma_3813	2.145e-68	251.0	COG1082@1|root,COG1082@2|Bacteria,4NJJZ@976|Bacteroidetes,47PI6@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DTH2_k127_6602393_9	435591.BDI_2473	2.271e-30	137.0	COG1413@1|root,COG1413@2|Bacteria,4NK5S@976|Bacteroidetes	976|Bacteroidetes	C	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
DTH2_k127_6602393_0	452637.Oter_3513	9.018e-141	460.0	COG0673@1|root,COG0673@2|Bacteria,46ZKA@74201|Verrucomicrobia,3K93V@414999|Opitutae	414999|Opitutae	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_6602393_4	243090.RB4846	2.43e-96	338.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
DTH2_k127_6602393_3	234267.Acid_2166	3.327e-113	381.0	COG1457@1|root,COG1457@2|Bacteria,3Y6MB@57723|Acidobacteria	57723|Acidobacteria	F	Belongs to the purine-cytosine permease (2.A.39) family	-	-	-	ko:K10974	-	-	-	-	ko00000,ko02000	2.A.39.1	-	-	Transp_cyt_pur
DTH2_k127_6602393_7	452637.Oter_3514	9.119e-56	204.0	2F286@1|root,33V6C@2|Bacteria,46V8R@74201|Verrucomicrobia,3K9H5@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6602393_5	1403819.BATR01000114_gene3949	4.935e-72	272.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DTH2_k127_6602393_8	1396418.BATQ01000117_gene4549	6.048e-36	158.0	COG1477@1|root,COG1477@2|Bacteria,46VJI@74201|Verrucomicrobia,2IW89@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	ApbE family	-	-	-	-	-	-	-	-	-	-	-	-	ApbE
DTH2_k127_6602393_2	497964.CfE428DRAFT_2358	1.445e-121	403.0	COG0513@1|root,COG0513@2|Bacteria,46S5M@74201|Verrucomicrobia	74201|Verrucomicrobia	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
DTH2_k127_6602393_1	639282.DEFDS_1109	5.167e-128	420.0	COG2804@1|root,COG2804@2|Bacteria,2GEP7@200930|Deferribacteres	200930|Deferribacteres	NU	General secretory system II protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DTH2_k127_6637734_3	643562.Daes_2562	1.764e-46	179.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria,2MBEI@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
DTH2_k127_6637734_1	398767.Glov_3666	4.843e-139	454.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
DTH2_k127_6637734_0	1195236.CTER_4163	8.428e-146	469.0	COG0637@1|root,COG0637@2|Bacteria,1VSTY@1239|Firmicutes,24Z1J@186801|Clostridia	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
DTH2_k127_6637734_2	756272.Plabr_2751	7.163e-80	278.0	COG3481@1|root,COG3481@2|Bacteria,2IX5B@203682|Planctomycetes	203682|Planctomycetes	S	Nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
DTH2_k127_6637734_4	1517682.HW49_04500	5.581e-29	119.0	COG3877@1|root,COG3877@2|Bacteria,4NVHG@976|Bacteroidetes,2FT1Y@200643|Bacteroidia,22YRD@171551|Porphyromonadaceae	976|Bacteroidetes	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
DTH2_k127_6637734_5	742767.HMPREF9456_02138	0.0001815	45.0	2C6HF@1|root,32XWI@2|Bacteria,4NU6D@976|Bacteroidetes,2G2JK@200643|Bacteroidia,22YTN@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6656857_1	1031288.AXAA01000013_gene514	3.922e-59	209.0	COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia,36F9G@31979|Clostridiaceae	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
DTH2_k127_6656857_2	717774.Marme_1409	1.004e-50	190.0	COG0702@1|root,COG0702@2|Bacteria,1QRSF@1224|Proteobacteria,1S5R4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
DTH2_k127_6656857_3	1121396.KB893107_gene1842	1.212e-47	179.0	COG0500@1|root,COG2226@2|Bacteria,1RB5H@1224|Proteobacteria,43AXN@68525|delta/epsilon subdivisions,2WMND@28221|Deltaproteobacteria,2MMIF@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DTH2_k127_6656857_4	1265505.ATUG01000002_gene1043	3.212e-38	156.0	2C4IE@1|root,30ERP@2|Bacteria,1RG2Q@1224|Proteobacteria,42S4W@68525|delta/epsilon subdivisions,2WND7@28221|Deltaproteobacteria,2MN1X@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6656857_0	338963.Pcar_2872	1.009e-75	255.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,43T34@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2834	Prismane
DTH2_k127_6659792_1	697281.Mahau_1206	3.986e-136	468.0	COG3408@1|root,COG3408@2|Bacteria,1TSSU@1239|Firmicutes,24BK6@186801|Clostridia	186801|Clostridia	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H
DTH2_k127_6659792_5	243090.RB680	8.894e-75	262.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,2J1WF@203682|Planctomycetes	203682|Planctomycetes	K	AraC-like ligand binding domain	-	-	-	ko:K02854	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
DTH2_k127_6659792_4	1307759.JOMJ01000004_gene2437	1.672e-81	286.0	COG2223@1|root,COG2223@2|Bacteria,1MVFQ@1224|Proteobacteria,43CFE@68525|delta/epsilon subdivisions,2X7QH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
DTH2_k127_6659792_3	667014.Thein_0038	1.135e-88	311.0	COG0009@1|root,COG0009@2|Bacteria,2GGWC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Telomere recombination	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
DTH2_k127_6659792_7	1002339.HMPREF9373_0400	0.0001291	46.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,3NIIB@468|Moraxellaceae	1236|Gammaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Chorismate_synt
DTH2_k127_6659792_0	909663.KI867150_gene372	1.515e-183	592.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DTH2_k127_6659792_6	1167006.UWK_03050	3.951e-51	183.0	COG5609@1|root,COG5609@2|Bacteria,1NBSG@1224|Proteobacteria,42V10@68525|delta/epsilon subdivisions,2WRVV@28221|Deltaproteobacteria,2MNRX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterized conserved protein (DUF2294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2294
DTH2_k127_6659792_2	237368.SCABRO_00503	1.853e-104	346.0	COG0249@1|root,COG0249@2|Bacteria,2IXGV@203682|Planctomycetes	203682|Planctomycetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
DTH2_k127_6693600_4	1191523.MROS_1561	1.398e-11	65.0	COG0111@1|root,COG0111@2|Bacteria	2|Bacteria	EH	4-phosphoerythronate dehydrogenase activity	pdxB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z3582	2-Hacid_dh,2-Hacid_dh_C,DUF3410
DTH2_k127_6693600_0	240016.ABIZ01000001_gene5157	2.847e-109	368.0	COG0577@1|root,COG0577@2|Bacteria,46TQS@74201|Verrucomicrobia,2IWMB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
DTH2_k127_6693600_2	1403819.BATR01000070_gene2105	4.166e-78	267.0	COG1136@1|root,COG1136@2|Bacteria,46SI5@74201|Verrucomicrobia,2IUA4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH2_k127_6693600_1	1396418.BATQ01000030_gene5616	3.665e-79	286.0	COG0845@1|root,COG0845@2|Bacteria,46WF0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
DTH2_k127_6693600_3	240016.ABIZ01000001_gene5154	3.06e-72	260.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
DTH2_k127_6705239_1	1387312.BAUS01000004_gene1595	3.594e-44	164.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,2KKIJ@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
DTH2_k127_6705239_0	913865.DOT_0088	8.402e-47	178.0	COG0320@1|root,COG0321@1|root,COG0320@2|Bacteria,COG0321@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,2619Z@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
DTH2_k127_6705239_3	1237149.C900_05801	2.938e-29	130.0	COG0486@1|root,COG0486@2|Bacteria,4NECT@976|Bacteroidetes,47JRR@768503|Cytophagia	976|Bacteroidetes	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
DTH2_k127_6705239_2	247490.KSU1_C0153	6.465e-31	131.0	COG1521@1|root,COG1521@2|Bacteria,2J0M0@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
DTH2_k127_6747126_1	1089553.Tph_c26720	2.147e-54	198.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,42FEE@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
DTH2_k127_6747126_3	1410633.JHWR01000001_gene1352	2.954e-18	95.0	COG3584@1|root,COG3584@2|Bacteria,1VGG7@1239|Firmicutes,259JY@186801|Clostridia,27NSC@186928|unclassified Lachnospiraceae	186801|Clostridia	M	3D domain	-	-	-	-	-	-	-	-	-	-	-	-	3D,SH3_3
DTH2_k127_6747126_0	756272.Plabr_2112	2.712e-154	499.0	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
DTH2_k127_6747126_2	502025.Hoch_2564	1.233e-37	156.0	COG4191@1|root,COG4191@2|Bacteria,1R9SH@1224|Proteobacteria,42QAE@68525|delta/epsilon subdivisions,2WM61@28221|Deltaproteobacteria,2Z2WP@29|Myxococcales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,dCache_1
DTH2_k127_6747126_4	1191523.MROS_0632	5.262e-09	59.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
DTH2_k127_6750587_0	1041930.Mtc_2239	7.895e-91	305.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,2N9BE@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DTH2_k127_6750587_1	1142394.PSMK_03840	2.337e-89	307.0	COG0592@1|root,COG0592@2|Bacteria,2IY9S@203682|Planctomycetes	203682|Planctomycetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
DTH2_k127_6750587_2	1235799.C818_03097	1.121e-78	276.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,27IPK@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DTH2_k127_6754754_0	1392493.JIAB01000001_gene467	2.315e-92	308.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,27I6F@186928|unclassified Lachnospiraceae	186801|Clostridia	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
DTH2_k127_6754754_2	589865.DaAHT2_0948	1.964e-29	122.0	COG1661@1|root,COG1661@2|Bacteria,1RIUJ@1224|Proteobacteria,42SC0@68525|delta/epsilon subdivisions,2WPPG@28221|Deltaproteobacteria,2MKD3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF296)	-	-	-	-	-	-	-	-	-	-	-	-	DUF296
DTH2_k127_6754754_1	530564.Psta_3113	4.777e-37	144.0	COG0727@1|root,COG0727@2|Bacteria,2IZM1@203682|Planctomycetes	203682|Planctomycetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DTH2_k127_6754754_3	1535422.ND16A_0310	4.207e-05	51.0	COG3325@1|root,COG3325@2|Bacteria	2|Bacteria	G	chitin binding	chiA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18
DTH2_k127_6782303_0	1142394.PSMK_05510	5.179e-85	296.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2IXKU@203682|Planctomycetes	203682|Planctomycetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
DTH2_k127_6782303_1	1278073.MYSTI_04769	1.23e-28	124.0	COG3157@1|root,COG3157@2|Bacteria,1MXFB@1224|Proteobacteria,42UFI@68525|delta/epsilon subdivisions,2WQZ4@28221|Deltaproteobacteria,2YW32@29|Myxococcales	28221|Deltaproteobacteria	S	Type VI secretion system effector, Hcp	tssD	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
DTH2_k127_6799576_4	794903.OPIT5_17290	7.449e-35	135.0	COG1129@1|root,COG1129@2|Bacteria,46UQP@74201|Verrucomicrobia,3K90Q@414999|Opitutae	414999|Opitutae	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
DTH2_k127_6799576_1	661478.OP10G_4483	3.629e-98	332.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17203	ko02010,map02010	M00212,M00590	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.16,3.A.1.2.19	-	-	BPD_transp_2
DTH2_k127_6799576_0	756272.Plabr_0383	1.211e-142	466.0	COG0322@1|root,COG0322@2|Bacteria,2IWVR@203682|Planctomycetes	203682|Planctomycetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,UVR,UvrC_HhH_N
DTH2_k127_6799576_3	880073.Calab_2922	1.151e-44	174.0	28K48@1|root,2Z9T8@2|Bacteria,2NR0P@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405
DTH2_k127_683145_5	161528.ED21_27283	0.0004975	47.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2K09E@204457|Sphingomonadales	204457|Sphingomonadales	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
DTH2_k127_683145_3	313628.LNTAR_22105	9.136e-09	66.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
DTH2_k127_683145_1	880072.Desac_0771	8.536e-50	190.0	2DV5M@1|root,33U68@2|Bacteria,1NUIA@1224|Proteobacteria,42ZFX@68525|delta/epsilon subdivisions,2WV1Z@28221|Deltaproteobacteria	880072.Desac_0771|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_683145_4	1210884.HG799462_gene8540	3.332e-06	56.0	2DPBR@1|root,331ES@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_683145_2	1246995.AFR_12125	2.164e-22	97.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
DTH2_k127_683145_0	1499967.BAYZ01000102_gene3556	3.403e-143	467.0	COG0826@1|root,COG0826@2|Bacteria,2NPQH@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DTH2_k127_6833441_1	460265.Mnod_5003	1.561e-19	93.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,1JZK8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
DTH2_k127_6833441_0	1303518.CCALI_00133	5.126e-99	350.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	galA	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_4_9,CBM_6,DUF1565
DTH2_k127_6837225_3	547042.BACCOPRO_01963	0.0006987	53.0	COG0457@1|root,COG1729@1|root,COG4105@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG4105@2|Bacteria,4NE4W@976|Bacteroidetes,2FM3C@200643|Bacteroidia,4AM5H@815|Bacteroidaceae	976|Bacteroidetes	S	Tetratricopeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
DTH2_k127_6837225_1	575540.Isop_0532	2.187e-94	323.0	COG0438@1|root,COG0438@2|Bacteria,2IXN1@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DTH2_k127_6837225_2	247490.KSU1_D0726	1.054e-60	218.0	COG0101@1|root,COG0101@2|Bacteria,2IYSC@203682|Planctomycetes	203682|Planctomycetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
DTH2_k127_6837225_0	402881.Plav_3501	1.768e-122	401.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,1JN9Q@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DTH2_k127_6878702_1	1125863.JAFN01000001_gene2285	1.921e-05	53.0	COG3167@1|root,COG3167@2|Bacteria,1MZZ4@1224|Proteobacteria,43B6P@68525|delta/epsilon subdivisions,2X6K9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM Pilus assembly protein PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
DTH2_k127_6878702_0	1142394.PSMK_14360	2.764e-28	123.0	COG4796@1|root,COG4796@2|Bacteria,2IY1C@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the GSP D family	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	STN,Secretin
DTH2_k127_6898692_1	1121033.AUCF01000001_gene2411	3.483e-31	124.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2TUAA@28211|Alphaproteobacteria,2JQT1@204441|Rhodospirillales	204441|Rhodospirillales	KO	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
DTH2_k127_6898692_2	1385517.N800_09725	1.182e-07	58.0	COG1652@1|root,COG1652@2|Bacteria,1N3P8@1224|Proteobacteria,1SY85@1236|Gammaproteobacteria,1X82C@135614|Xanthomonadales	135614|Xanthomonadales	S	peptidoglycan-binding protein, lysm	-	-	-	-	-	-	-	-	-	-	-	-	LysM
DTH2_k127_6898692_0	1142394.PSMK_23630	4.86e-145	498.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2IYCQ@203682|Planctomycetes	203682|Planctomycetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	SecD_SecF,Sec_GG
DTH2_k127_6960043_2	1142394.PSMK_07740	2.448e-32	134.0	COG0204@1|root,COG0204@2|Bacteria,2IZVC@203682|Planctomycetes	203682|Planctomycetes	I	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
DTH2_k127_6960043_0	344747.PM8797T_30347	7.142e-53	195.0	COG0283@1|root,COG0283@2|Bacteria,2IZ6S@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
DTH2_k127_6965942_2	401526.TcarDRAFT_1038	7.625e-07	51.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,4H2TK@909932|Negativicutes	909932|Negativicutes	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
DTH2_k127_6965942_1	28042.GU90_01465	5.781e-74	258.0	COG0388@1|root,COG0388@2|Bacteria,2I9ZC@201174|Actinobacteria,4E6QQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DTH2_k127_6965942_0	1210884.HG799476_gene15402	2.451e-104	348.0	COG0002@1|root,COG0002@2|Bacteria,2IXTC@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DTH2_k127_696811_0	251229.Chro_0863	9.739e-37	156.0	COG3385@1|root,COG3385@2|Bacteria,1G3T3@1117|Cyanobacteria,3VMB3@52604|Pleurocapsales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
DTH2_k127_7000441_0	457570.Nther_0465	2.884e-131	434.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
DTH2_k127_7059976_0	1121918.ARWE01000001_gene2756	7.907e-79	277.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42P0U@68525|delta/epsilon subdivisions,2WJC6@28221|Deltaproteobacteria,43T6F@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
DTH2_k127_7059976_1	393921.HQ45_00755	2.081e-32	127.0	COG0013@1|root,COG0013@2|Bacteria,4NFHW@976|Bacteroidetes,2FN1R@200643|Bacteroidia,22XC2@171551|Porphyromonadaceae	976|Bacteroidetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DTH2_k127_7062331_2	756272.Plabr_0652	3.691e-65	234.0	COG1519@1|root,COG1519@2|Bacteria,2IYCJ@203682|Planctomycetes	203682|Planctomycetes	M	transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
DTH2_k127_7062331_3	278957.ABEA03000197_gene445	7.697e-57	218.0	COG0840@1|root,COG0840@2|Bacteria,46Y7J@74201|Verrucomicrobia,3K92D@414999|Opitutae	414999|Opitutae	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
DTH2_k127_7062331_1	644282.Deba_0997	6.038e-91	309.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42Q7T@68525|delta/epsilon subdivisions,2WJ26@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Hydrogenase (NiFe) small subunit HydA	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,UCR_Fe-S_N
DTH2_k127_7062331_0	644282.Deba_0998	7.25e-168	542.0	COG0374@1|root,COG0374@2|Bacteria,1NENZ@1224|Proteobacteria,42PAN@68525|delta/epsilon subdivisions,2WK7I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	hydrogenase large subunit	-	-	1.12.7.2,1.12.99.6	ko:K00533,ko:K06281	ko00633,ko01120,map00633,map01120	-	R00019,R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
DTH2_k127_7062331_4	1437425.CSEC_1519	1.631e-18	87.0	COG4760@1|root,COG4760@2|Bacteria,2JFEY@204428|Chlamydiae	204428|Chlamydiae	S	Bax inhibitor 1 like	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
DTH2_k127_7073595_2	247490.KSU1_B0100	2.628e-92	306.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
DTH2_k127_7073595_6	351160.LRC431	9.875e-17	87.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,2N9TV@224756|Methanomicrobia	224756|Methanomicrobia	F	adenylyl cyclase CyaB	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
DTH2_k127_7073595_4	530564.Psta_3992	5.439e-39	157.0	COG1597@1|root,COG1597@2|Bacteria,2IZX6@203682|Planctomycetes	203682|Planctomycetes	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
DTH2_k127_7073595_1	1121456.ATVA01000016_gene2196	4.608e-94	315.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2M90H@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
DTH2_k127_7073595_3	1089553.Tph_c22610	7.381e-77	271.0	COG0731@1|root,COG0731@2|Bacteria,1TSYW@1239|Firmicutes,24CEP@186801|Clostridia,42ID6@68295|Thermoanaerobacterales	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
DTH2_k127_7073595_8	243090.RB6002	0.0008835	45.0	2E3N9@1|root,32YKE@2|Bacteria,2J0MA@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7073595_0	1142394.PSMK_28200	3.218e-95	322.0	COG4974@1|root,COG4974@2|Bacteria,2IX6A@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
DTH2_k127_7073595_5	886293.Sinac_5046	2.127e-30	127.0	COG0250@1|root,COG0250@2|Bacteria,2J0E8@203682|Planctomycetes	203682|Planctomycetes	K	PFAM Transcription termination factor nusG	-	-	-	ko:K05785	-	-	-	-	ko00000,ko03000	-	-	-	NusG
DTH2_k127_7073595_7	472759.Nhal_1980	8.379e-11	67.0	2DD9Q@1|root,2ZH70@2|Bacteria,1P8P5@1224|Proteobacteria,1SWFT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7096797_1	768670.Calni_0951	4.06e-10	73.0	COG0265@1|root,COG0265@2|Bacteria,2GERQ@200930|Deferribacteres	2|Bacteria	M	PFAM peptidase S1 and S6 chymotrypsin Hap	degQ	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
DTH2_k127_7096797_0	1123508.JH636439_gene1727	9.352e-119	395.0	COG2262@1|root,COG2262@2|Bacteria,2IXH5@203682|Planctomycetes	203682|Planctomycetes	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
DTH2_k127_7098359_1	710696.Intca_0186	2.459e-60	216.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FFQG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
DTH2_k127_7098359_3	269799.Gmet_2440	1.227e-33	139.0	COG0619@1|root,COG0619@2|Bacteria,1R2DN@1224|Proteobacteria,43B6A@68525|delta/epsilon subdivisions,2X6JT@28221|Deltaproteobacteria,43S05@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Cobalt transport protein	nikQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
DTH2_k127_7098359_0	1122947.FR7_1024	5.066e-62	226.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,4H2UH@909932|Negativicutes	909932|Negativicutes	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM protein	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
DTH2_k127_7098359_4	1207075.PputUW4_00990	7.105e-22	109.0	COG3659@1|root,COG3659@2|Bacteria,1NTGF@1224|Proteobacteria,1SZPI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Carbohydrate-selective porin	oprB2	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
DTH2_k127_7098359_2	574087.Acear_0853	6.528e-35	138.0	COG0864@1|root,COG0864@2|Bacteria,1V5TB@1239|Firmicutes,24HRD@186801|Clostridia,3WBVX@53433|Halanaerobiales	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
DTH2_k127_7129253_0	1142394.PSMK_11860	4.358e-108	360.0	COG1995@1|root,COG1995@2|Bacteria,2IYEZ@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the PdxA family	pdxA	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
DTH2_k127_7129253_1	56780.SYN_01562	8.83e-57	205.0	COG2020@1|root,COG2020@2|Bacteria,1RJNV@1224|Proteobacteria,42TNF@68525|delta/epsilon subdivisions,2WQ1R@28221|Deltaproteobacteria,2MRXW@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
DTH2_k127_7129253_2	314292.VAS14_15769	8.58e-06	54.0	2DBFB@1|root,2Z8XA@2|Bacteria,1MVTN@1224|Proteobacteria,1RM97@1236|Gammaproteobacteria,1XUIN@135623|Vibrionales	135623|Vibrionales	S	Protein of unknown function (DUF4056)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4056
DTH2_k127_717648_3	697281.Mahau_2681	3.389e-105	370.0	COG5492@1|root,COG5492@2|Bacteria,1UIHA@1239|Firmicutes,25GPW@186801|Clostridia,42IXE@68295|Thermoanaerobacterales	1239|Firmicutes	N	Ig domain protein group 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CBM_6
DTH2_k127_717648_7	714943.Mucpa_5701	1.232e-06	54.0	COG2801@1|root,COG2801@2|Bacteria,4NIBY@976|Bacteroidetes,1ITSB@117747|Sphingobacteriia	976|Bacteroidetes	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
DTH2_k127_717648_1	357808.RoseRS_3616	2.294e-182	590.0	COG3525@1|root,COG3525@2|Bacteria,2G609@200795|Chloroflexi,376QW@32061|Chloroflexia	32061|Chloroflexia	G	Glycoside hydrolase, family 20	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20,Glyco_hydro_20b
DTH2_k127_717648_6	1168034.FH5T_01570	2.743e-46	180.0	COG3391@1|root,COG3391@2|Bacteria,4PC69@976|Bacteroidetes,2G01G@200643|Bacteroidia	976|Bacteroidetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_717648_5	1168034.FH5T_01560	5.93e-62	218.0	2DVMZ@1|root,33WFQ@2|Bacteria,4P3VR@976|Bacteroidetes,2FXVM@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	-
DTH2_k127_717648_2	1168034.FH5T_01555	1.503e-106	359.0	COG0348@1|root,COG0348@2|Bacteria,4NPVD@976|Bacteroidetes,2FTEY@200643|Bacteroidia	976|Bacteroidetes	C	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
DTH2_k127_717648_4	497964.CfE428DRAFT_5712	5.686e-82	294.0	COG1520@1|root,COG1520@2|Bacteria,46THI@74201|Verrucomicrobia	2|Bacteria	S	SMART Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
DTH2_k127_717648_0	69014.TK1613	5.201e-200	648.0	COG1894@1|root,COG4231@1|root,arCOG01609@2157|Archaea,arCOG04537@2157|Archaea,2XUYN@28890|Euryarchaeota,243V2@183968|Thermococci	183968|Thermococci	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DTH2_k127_7205518_3	574087.Acear_1005	8.132e-30	120.0	arCOG15062@1|root,32Y8D@2|Bacteria,1VEUQ@1239|Firmicutes,24TKJ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PQ-loop
DTH2_k127_7205518_1	1196324.A374_16783	1.132e-57	209.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli	91061|Bacilli	L	Hydrolase, tatd	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
DTH2_k127_7205518_5	1392486.JIAF01000004_gene2061	3.791e-19	93.0	COG0792@1|root,COG0792@2|Bacteria,4NS7E@976|Bacteroidetes,2FSN9@200643|Bacteroidia	976|Bacteroidetes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
DTH2_k127_7205518_2	314230.DSM3645_06704	3.236e-35	138.0	COG0335@1|root,COG0335@2|Bacteria,2IZVX@203682|Planctomycetes	203682|Planctomycetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
DTH2_k127_7205518_0	1121938.AUDY01000008_gene1555	6.091e-85	287.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,3ND2P@45667|Halobacillus	91061|Bacilli	J	tRNA (Guanine-1)-methyltransferase	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
DTH2_k127_7205518_4	1123306.KB904340_gene535	8.116e-21	97.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
DTH2_k127_72306_8	1122604.JONR01000075_gene726	1.599e-42	174.0	COG0467@1|root,COG0467@2|Bacteria	2|Bacteria	T	regulation of circadian rhythm	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	AAA_25,MEDS,PriCT_2,Prim-Pol,RepB_primase
DTH2_k127_72306_11	518635.BIFANG_02028	6.017e-14	85.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4CYY3@85004|Bifidobacteriales	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
DTH2_k127_72306_2	456442.Mboo_1629	3.595e-130	422.0	COG2899@1|root,arCOG05299@2157|Archaea,2Y4HF@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
DTH2_k127_72306_1	886293.Sinac_5251	1.343e-168	551.0	COG1199@1|root,COG1199@2|Bacteria,2IX82@203682|Planctomycetes	203682|Planctomycetes	KL	helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
DTH2_k127_72306_7	237368.SCABRO_01251	3.497e-53	198.0	COG0061@1|root,COG0061@2|Bacteria,2IXD3@203682|Planctomycetes	203682|Planctomycetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
DTH2_k127_72306_0	247490.KSU1_D0796	2.942e-171	558.0	COG1154@1|root,COG1154@2|Bacteria,2IYHC@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
DTH2_k127_72306_9	1121929.KB898671_gene4133	9.321e-42	164.0	COG1409@1|root,COG1409@2|Bacteria,1VMBT@1239|Firmicutes,4HUFU@91061|Bacilli	91061|Bacilli	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DTH2_k127_72306_6	314230.DSM3645_22886	4.263e-65	233.0	COG0142@1|root,COG0142@2|Bacteria,2IX56@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
DTH2_k127_72306_4	1210884.HG799465_gene11519	1.072e-68	244.0	COG0324@1|root,COG0324@2|Bacteria,2IYY6@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
DTH2_k127_72306_5	1499967.BAYZ01000181_gene4487	2.448e-66	236.0	COG0646@1|root,COG0646@2|Bacteria,2NP9A@2323|unclassified Bacteria	2|Bacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
DTH2_k127_72306_10	1210884.HG799462_gene8390	8.235e-24	107.0	2BWMY@1|root,331GB@2|Bacteria,2J0M4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_72306_12	309803.CTN_1515	1.293e-07	58.0	COG1555@1|root,COG1555@2|Bacteria,2GD8U@200918|Thermotogae	200918|Thermotogae	L	TIGRFAM competence protein ComEA helix-hairpin-helix repeat	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
DTH2_k127_72306_3	1142394.PSMK_21970	5.223e-82	291.0	COG3693@1|root,COG3693@2|Bacteria,2IXI6@203682|Planctomycetes	203682|Planctomycetes	G	PFAM glycoside hydrolase, family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_10
DTH2_k127_72306_14	1304885.AUEY01000019_gene1167	0.0001951	44.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,42P6V@68525|delta/epsilon subdivisions,2WM6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
DTH2_k127_7276809_0	744872.Spica_0934	1.067e-167	530.0	COG0334@1|root,COG0334@2|Bacteria,2J5DD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdh	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DTH2_k127_7276809_2	583355.Caka_0413	1.832e-72	254.0	COG0583@1|root,COG0583@2|Bacteria,46SCJ@74201|Verrucomicrobia,3K7FY@414999|Opitutae	414999|Opitutae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
DTH2_k127_7276809_5	1380387.JADM01000004_gene2859	2.177e-33	139.0	COG0546@1|root,COG0546@2|Bacteria,1RHAA@1224|Proteobacteria,1S7HQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hydrolase	pgp	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
DTH2_k127_7276809_3	1499967.BAYZ01000080_gene896	4.611e-45	168.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5
DTH2_k127_7276809_1	290318.Cvib_1132	7.471e-152	486.0	COG3943@1|root,COG3943@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_RhuM
DTH2_k127_7276809_4	247490.KSU1_C1680	1.76e-39	151.0	COG0764@1|root,COG0764@2|Bacteria,2IZNA@203682|Planctomycetes	203682|Planctomycetes	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
DTH2_k127_7276809_10	1453501.JELR01000001_gene2400	5.614e-11	74.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,4644T@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
DTH2_k127_7276809_12	87626.PTD2_04958	2.191e-05	47.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7276809_8	469381.Dpep_1591	2.733e-18	85.0	COG1036@1|root,COG1036@2|Bacteria,3TCJM@508458|Synergistetes	508458|Synergistetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DTH2_k127_7276809_6	945713.IALB_0239	2.501e-33	134.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
DTH2_k127_7276809_7	858215.Thexy_1896	2.926e-28	124.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,42FNR@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Phosphoribosyltransferase	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
DTH2_k127_7276809_9	344747.PM8797T_07909	2.391e-12	71.0	COG4968@1|root,COG4968@2|Bacteria,2J519@203682|Planctomycetes	203682|Planctomycetes	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
DTH2_k127_7298203_6	1121403.AUCV01000003_gene1849	6.041e-33	131.0	COG3437@1|root,COG3437@2|Bacteria,1QWQ2@1224|Proteobacteria,42TXK@68525|delta/epsilon subdivisions,2WQ10@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
DTH2_k127_7298203_4	439235.Dalk_2352	6.157e-47	173.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42QS2@68525|delta/epsilon subdivisions,2WMXG@28221|Deltaproteobacteria,2MJMH@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
DTH2_k127_7298203_0	338963.Pcar_3031	5.174e-127	417.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,42M6F@68525|delta/epsilon subdivisions,2WK37@28221|Deltaproteobacteria,43TKI@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH2_k127_7298203_2	886293.Sinac_6467	3.5e-98	332.0	COG4956@1|root,COG4956@2|Bacteria,2IXF3@203682|Planctomycetes	203682|Planctomycetes	S	Integral membrane protein (PIN domain superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	PIN_4,TRAM
DTH2_k127_7298203_5	1454004.AW11_02942	3.253e-37	156.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DTH2_k127_7298203_7	530564.Psta_2780	2.416e-11	67.0	2E607@1|root,330PM@2|Bacteria,2J0MD@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7298203_1	1123373.ATXI01000023_gene1785	1.034e-118	402.0	COG0438@1|root,COG0438@2|Bacteria,2GHK9@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7298203_3	1210884.HG799470_gene14491	5.629e-86	301.0	COG1198@1|root,COG1198@2|Bacteria,2IY1F@203682|Planctomycetes	203682|Planctomycetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
DTH2_k127_7308648_0	1379270.AUXF01000002_gene1692	6.725e-152	497.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1ZTCI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
DTH2_k127_7308648_2	439235.Dalk_0657	1.42e-80	277.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2MJG1@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR34H	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
DTH2_k127_7308648_5	234267.Acid_5371	8.388e-41	156.0	COG1871@1|root,COG1871@2|Bacteria,3Y5E5@57723|Acidobacteria	57723|Acidobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
DTH2_k127_7308648_1	439235.Dalk_0655	1.613e-127	416.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2MHVY@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
DTH2_k127_7308648_3	555079.Toce_2028	7.312e-55	209.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia,42FAB@68295|Thermoanaerobacterales	186801|Clostridia	C	of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DTH2_k127_7308648_7	368407.Memar_1501	0.0009656	49.0	COG1418@1|root,arCOG01860@2157|Archaea,2XSXG@28890|Euryarchaeota,2NA06@224756|Methanomicrobia	224756|Methanomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
DTH2_k127_7308648_4	234267.Acid_7275	6.914e-48	177.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria	57723|Acidobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DTH2_k127_7308648_6	665571.STHERM_c17440	3.234e-17	83.0	COG0546@1|root,COG0546@2|Bacteria,2J7K0@203691|Spirochaetes	203691|Spirochaetes	S	Phosphoglycolate phosphatase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH2_k127_7341910_2	671143.DAMO_1588	4.974e-98	340.0	COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C assembly protein	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564	-	ko:K02198,ko:K04016	-	-	R05712	RC00176	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
DTH2_k127_7341910_8	525904.Tter_1510	4.129e-16	89.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
DTH2_k127_7341910_4	479434.Sthe_1412	2.28e-49	185.0	COG1131@1|root,COG1131@2|Bacteria,2G6IS@200795|Chloroflexi,27YFZ@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
DTH2_k127_7341910_7	485913.Krac_8609	3.905e-20	99.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
DTH2_k127_7341910_6	1121434.AULY01000009_gene1888	1.903e-32	134.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,42RU4@68525|delta/epsilon subdivisions,2WNN7@28221|Deltaproteobacteria,2M9X3@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM Cytochrome c assembly protein	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
DTH2_k127_7341910_3	1142394.PSMK_14720	5.62e-96	322.0	COG0548@1|root,COG0548@2|Bacteria,2IWVV@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
DTH2_k127_7341910_0	247490.KSU1_D0944	7.184e-154	495.0	COG4992@1|root,COG4992@2|Bacteria,2IWTF@203682|Planctomycetes	203682|Planctomycetes	E	COG4992 Ornithine acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH2_k127_7341910_1	484770.UFO1_0618	7.051e-99	331.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H278@909932|Negativicutes	909932|Negativicutes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DTH2_k127_7341910_5	646529.Desaci_4357	7.023e-35	139.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,261IR@186807|Peptococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
DTH2_k127_7404306_1	313612.L8106_21674	5.882e-36	150.0	COG0398@1|root,COG0398@2|Bacteria,1G3R9@1117|Cyanobacteria,1H8VH@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
DTH2_k127_7404306_0	1123508.JH636439_gene1482	6.148e-45	169.0	COG1212@1|root,COG1212@2|Bacteria,2IYWF@203682|Planctomycetes	203682|Planctomycetes	H	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
DTH2_k127_7441902_0	1232437.KL662016_gene1055	9.395e-134	434.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2MIUJ@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
DTH2_k127_7441902_2	243164.DET1404	1.946e-46	172.0	COG3359@1|root,COG3359@2|Bacteria,2G6TK@200795|Chloroflexi,34CWC@301297|Dehalococcoidia	301297|Dehalococcoidia	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
DTH2_k127_7441902_1	743721.Psesu_0802	5.417e-78	271.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1X3ZA@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
DTH2_k127_7441902_3	305900.GV64_17700	1.179e-31	130.0	COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,1XHAR@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate	pdxB	-	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C,DUF3410
DTH2_k127_7462891_1	32024.JMTI01000008_gene1227	1.569e-05	47.0	2A4CB@1|root,30SXZ@2|Bacteria,1PCGS@1224|Proteobacteria,42W82@68525|delta/epsilon subdivisions,2YQMV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7462891_0	697282.Mettu_0436	0.0	1273.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1XDPR@135618|Methylococcales	135618|Methylococcales	G	PFAM Xylulose 5-phosphate Fructose 6-phosphate phosphoketolase, N-terminal	-	GO:0003674,GO:0003824,GO:0008150,GO:0009758	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
DTH2_k127_7499865_1	243090.RB11223	2.377e-21	97.0	COG0640@1|root,COG0640@2|Bacteria,2J3B8@203682|Planctomycetes	2|Bacteria	K	Bacterial regulatory protein, arsR	ybzH	-	-	-	-	-	-	-	-	-	-	-	DUF43,HTH_20
DTH2_k127_7499865_0	1313304.CALK_1633	8.178e-132	429.0	COG0137@1|root,COG0137@2|Bacteria	2|Bacteria	E	argininosuccinate synthase activity	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
DTH2_k127_7550447_2	1150474.JQJI01000005_gene338	3.014e-31	128.0	COG1509@1|root,COG1509@2|Bacteria,2GC4U@200918|Thermotogae	200918|Thermotogae	C	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_14,LAM_C,Radical_SAM
DTH2_k127_7550447_3	391038.Bphy_3540	1.048e-10	70.0	COG1309@1|root,COG1309@2|Bacteria,1N6P0@1224|Proteobacteria,2WAB5@28216|Betaproteobacteria,1K38R@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DTH2_k127_7550447_0	1123242.JH636436_gene121	2.499e-168	553.0	COG4122@1|root,COG4122@2|Bacteria,2IXSM@203682|Planctomycetes	203682|Planctomycetes	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7550447_1	1124780.ANNU01000036_gene30	1.803e-37	144.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,47K1Z@768503|Cytophagia	976|Bacteroidetes	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
DTH2_k127_7604220_3	945713.IALB_0403	4.832e-74	256.0	COG4912@1|root,COG4912@2|Bacteria	2|Bacteria	L	Dna alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
DTH2_k127_7604220_7	344747.PM8797T_15181	7.593e-29	119.0	COG2331@1|root,COG2331@2|Bacteria,2J0TW@203682|Planctomycetes	203682|Planctomycetes	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
DTH2_k127_7604220_8	1123405.AUMM01000052_gene2620	3.023e-26	116.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,26NXW@186821|Sporolactobacillaceae	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
DTH2_k127_7604220_2	1042375.AFPL01000030_gene496	3.419e-115	382.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,464JW@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DTH2_k127_7604220_0	237368.SCABRO_03915	8.25e-222	701.0	COG0459@1|root,COG0459@2|Bacteria,2IXJW@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
DTH2_k127_7604220_6	1210884.HG799470_gene14375	1.938e-33	131.0	COG0234@1|root,COG0234@2|Bacteria,2J0E5@203682|Planctomycetes	203682|Planctomycetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
DTH2_k127_7604220_1	314230.DSM3645_04330	2.547e-203	646.0	COG0459@1|root,COG0459@2|Bacteria,2IWZS@203682|Planctomycetes	203682|Planctomycetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
DTH2_k127_7604220_5	530564.Psta_3613	9.019e-62	216.0	COG0503@1|root,COG0503@2|Bacteria,2IZ9H@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
DTH2_k127_7604220_4	323848.Nmul_A0703	3.426e-72	258.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,372NQ@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
DTH2_k127_7604220_9	1121918.ARWE01000001_gene2288	2.561e-09	58.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,43RZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Aminoacyl-tRNA editing domain	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
DTH2_k127_762127_2	1142394.PSMK_02400	6.376e-12	71.0	COG0727@1|root,COG0727@2|Bacteria,2J0KU@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_762127_0	717605.Theco_3925	5.942e-100	329.0	COG1225@1|root,COG1225@2|Bacteria,1V058@1239|Firmicutes,4HE2H@91061|Bacilli,26T9E@186822|Paenibacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
DTH2_k127_762127_1	909663.KI867151_gene3160	4.15e-60	216.0	COG2197@1|root,COG2197@2|Bacteria,1RARA@1224|Proteobacteria,43B1G@68525|delta/epsilon subdivisions,2X5U5@28221|Deltaproteobacteria,2MRK4@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DTH2_k127_7689357_0	794903.OPIT5_07360	7.594e-191	599.0	COG0057@1|root,COG0057@2|Bacteria,46S59@74201|Verrucomicrobia,3K77U@414999|Opitutae	414999|Opitutae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
DTH2_k127_7689357_2	335543.Sfum_0500	5.243e-94	315.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2MSCP@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
DTH2_k127_7689357_1	720554.Clocl_1153	1.793e-143	466.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,3WGM9@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglycerate kinase	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
DTH2_k127_7689357_3	1227360.C176_10292	7.695e-61	217.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26DNF@186818|Planococcaceae	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
DTH2_k127_7732500_3	511051.CSE_05990	1.373e-07	56.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
DTH2_k127_7732500_1	1415778.JQMM01000001_gene1828	8.081e-66	241.0	COG2188@1|root,COG2188@2|Bacteria,1QVF7@1224|Proteobacteria,1S5D3@1236|Gammaproteobacteria,1J8FY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Putative porin	-	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Porin_5
DTH2_k127_7732500_2	880072.Desac_0116	3.534e-10	64.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,42N40@68525|delta/epsilon subdivisions,2WKUV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
DTH2_k127_7732500_0	926550.CLDAP_35110	3.811e-104	347.0	COG0205@1|root,COG0205@2|Bacteria,2G6CJ@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DTH2_k127_778129_2	247490.KSU1_D0799	5.586e-90	304.0	COG1692@1|root,COG1692@2|Bacteria,2IXR1@203682|Planctomycetes	203682|Planctomycetes	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
DTH2_k127_778129_0	521674.Plim_2017	1.389e-154	505.0	COG1418@1|root,COG1418@2|Bacteria,2IX35@203682|Planctomycetes	203682|Planctomycetes	D	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
DTH2_k127_778129_4	1142394.PSMK_27400	3.148e-45	170.0	COG0745@1|root,COG0745@2|Bacteria,2IY82@203682|Planctomycetes	203682|Planctomycetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
DTH2_k127_778129_1	1410618.JNKI01000002_gene1048	8.942e-102	339.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,4H1ZY@909932|Negativicutes	909932|Negativicutes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DTH2_k127_778129_3	634498.mru_0182	1.068e-53	195.0	COG0118@1|root,arCOG00089@2157|Archaea,2XTJ7@28890|Euryarchaeota,23P5I@183925|Methanobacteria	183925|Methanobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DTH2_k127_7792697_5	1048834.TC41_3105	3.771e-08	58.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,4HKBQ@91061|Bacilli,27AE4@186823|Alicyclobacillaceae	91061|Bacilli	T	low molecular weight	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DTH2_k127_7792697_2	521674.Plim_2593	1.669e-41	158.0	COG0698@1|root,COG0698@2|Bacteria,2IZKI@203682|Planctomycetes	203682|Planctomycetes	G	COG0698 Ribose 5-phosphate isomerase RpiB	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
DTH2_k127_7792697_3	1184607.AUCHE_16_00210	1.156e-27	124.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,4F71P@85018|Dermatophilaceae	201174|Actinobacteria	F	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
DTH2_k127_7792697_1	530564.Psta_1776	4.335e-71	253.0	COG2239@1|root,COG2239@2|Bacteria,2IZDB@203682|Planctomycetes	203682|Planctomycetes	P	Divalent cation transporter	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE
DTH2_k127_7792697_0	56780.SYN_02504	1.05e-144	471.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2WKKF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM MltA domain protein	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
DTH2_k127_7792697_4	552811.Dehly_0149	3.128e-11	64.0	COG1236@1|root,COG1236@2|Bacteria,2G62G@200795|Chloroflexi,34D19@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
DTH2_k127_7884006_9	243090.RB1027	7.618e-13	75.0	COG0438@1|root,COG0438@2|Bacteria,2IXZX@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DTH2_k127_7884006_4	1210884.HG799474_gene15182	1.124e-63	226.0	COG1136@1|root,COG1136@2|Bacteria,2IZ2X@203682|Planctomycetes	203682|Planctomycetes	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
DTH2_k127_7884006_0	240016.ABIZ01000001_gene3146	1.17e-176	593.0	COG0577@1|root,COG0577@2|Bacteria,46U6N@74201|Verrucomicrobia	74201|Verrucomicrobia	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
DTH2_k127_7884006_1	1168034.FH5T_01575	8.69e-124	412.0	COG1520@1|root,COG1520@2|Bacteria,4P15Y@976|Bacteroidetes,2FWBU@200643|Bacteroidia	976|Bacteroidetes	S	PQQ-like domain	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2
DTH2_k127_7884006_6	1142394.PSMK_25130	2.128e-23	108.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
DTH2_k127_7884006_3	1396418.BATQ01000113_gene4631	8.415e-90	308.0	COG1723@1|root,COG1723@2|Bacteria	2|Bacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	yagE	-	-	-	-	-	-	-	-	-	-	-	DUF155
DTH2_k127_7884006_8	335543.Sfum_1481	1.143e-15	81.0	2DRBR@1|root,33B4T@2|Bacteria,1NHJT@1224|Proteobacteria,43EE5@68525|delta/epsilon subdivisions,2WSXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
DTH2_k127_7884006_5	290512.Paes_0705	1.931e-60	214.0	COG1945@1|root,COG1945@2|Bacteria,1FDKS@1090|Chlorobi	1090|Chlorobi	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
DTH2_k127_7884006_2	313606.M23134_04872	6.359e-107	353.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,47KSG@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DTH2_k127_7884006_7	926561.KB900617_gene1879	8.514e-23	103.0	COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia,3WACM@53433|Halanaerobiales	186801|Clostridia	M	PFAM Copper amine oxidase N-terminal domain	lytC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,Cu_amine_oxidN1
DTH2_k127_7998526_3	1121918.ARWE01000001_gene3340	2.637e-52	191.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,43UQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7998526_4	756272.Plabr_3919	0.0009325	46.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,2J2UB@203682|Planctomycetes	203682|Planctomycetes	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
DTH2_k127_7998526_2	865861.AZSU01000002_gene2813	5.498e-77	274.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,24BEY@186801|Clostridia,36J2T@31979|Clostridiaceae	186801|Clostridia	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
DTH2_k127_7998526_0	1201288.M900_0578	1.752e-113	388.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,42Z5J@68525|delta/epsilon subdivisions,2X7Z6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
DTH2_k127_7998526_1	1353529.M899_3108	1.413e-95	329.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,42Z5J@68525|delta/epsilon subdivisions,2X7Z6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
DTH2_k127_801300_1	247490.KSU1_A0031	1.21e-10	73.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
DTH2_k127_801300_0	1123242.JH636435_gene3009	2.572e-74	255.0	COG0854@1|root,COG0854@2|Bacteria,2IYJ4@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
DTH2_k127_8013709_1	530564.Psta_3610	3.993e-74	278.0	COG4972@1|root,COG4972@2|Bacteria,2IWXB@203682|Planctomycetes	203682|Planctomycetes	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
DTH2_k127_8013709_0	756499.Desde_3661	4.07e-87	305.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,25ZY0@186807|Peptococcaceae	186801|Clostridia	J	MiaB-like tRNA modifying enzyme	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
DTH2_k127_8013709_6	40041.SZO_05760	1.433e-19	99.0	COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,4HAKD@91061|Bacilli,1M9WS@119603|Streptococcus dysgalactiae group	91061|Bacilli	S	Beta-lactamase superfamily domain	vicX	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
DTH2_k127_8013709_2	1123508.JH636440_gene2121	6.031e-53	189.0	COG2088@1|root,COG2088@2|Bacteria,2IZR8@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the SpoVG family	-	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
DTH2_k127_8013709_5	247490.KSU1_D1035	5.077e-49	186.0	COG1947@1|root,COG1947@2|Bacteria,2IZ7X@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DTH2_k127_8013709_3	945713.IALB_0235	3.799e-51	191.0	COG1238@1|root,COG1238@2|Bacteria	2|Bacteria	I	metal cluster binding	MA20_20865	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	SNARE_assoc
DTH2_k127_8013709_4	237368.SCABRO_02563	1.826e-50	186.0	COG2078@1|root,COG2078@2|Bacteria,2J349@203682|Planctomycetes	203682|Planctomycetes	S	AMMECR1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
DTH2_k127_8019636_2	867903.ThesuDRAFT_01748	9.785e-28	116.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,3WCC4@538999|Clostridiales incertae sedis	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
DTH2_k127_8019636_1	867903.ThesuDRAFT_01749	9.106e-134	467.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,3WCHE@538999|Clostridiales incertae sedis	186801|Clostridia	L	ATP-dependent helicase deoxyribonuclease subunit B	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
DTH2_k127_8019636_0	671143.DAMO_2651	2.584e-176	567.0	COG0021@1|root,COG0021@2|Bacteria,2NS3T@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
DTH2_k127_808063_1	1124780.ANNU01000014_gene3892	3.234e-32	126.0	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,47Q5C@768503|Cytophagia	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_808063_2	317936.Nos7107_2651	6.257e-31	123.0	COG1669@1|root,COG1669@2|Bacteria,1G8GD@1117|Cyanobacteria,1HNZD@1161|Nostocales	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
DTH2_k127_808063_3	1232410.KI421428_gene1094	1.361e-27	115.0	COG2361@1|root,COG2361@2|Bacteria,1NA32@1224|Proteobacteria,43B8M@68525|delta/epsilon subdivisions,2X6MY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
DTH2_k127_808063_0	1379270.AUXF01000003_gene3637	5.666e-131	431.0	COG0488@1|root,COG0488@2|Bacteria,1ZSQT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ABC transporter C-terminal domain	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DTH2_k127_8084612_0	1123508.JH636440_gene2149	1.23e-105	359.0	COG1109@1|root,COG1109@2|Bacteria,2IXRS@203682|Planctomycetes	203682|Planctomycetes	G	PFAM Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DTH2_k127_8084612_2	675817.VDA_000887	6.766e-57	211.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1XSMN@135623|Vibrionales	135623|Vibrionales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
DTH2_k127_8084612_1	1037409.BJ6T_21760	3.968e-57	208.0	2C2X7@1|root,31WBU@2|Bacteria,1P2EC@1224|Proteobacteria,2UV16@28211|Alphaproteobacteria,3JWR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
DTH2_k127_8084612_6	643867.Ftrac_1896	4.6e-05	54.0	COG2356@1|root,COG2374@1|root,COG2356@2|Bacteria,COG2374@2|Bacteria,4NEGS@976|Bacteroidetes,47V5J@768503|Cytophagia	976|Bacteroidetes	L	Endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1,LTD,fn3
DTH2_k127_8084612_4	525897.Dbac_2439	3.408e-40	152.0	COG4852@1|root,COG4852@2|Bacteria,1MZHP@1224|Proteobacteria,42TD7@68525|delta/epsilon subdivisions,2WPIH@28221|Deltaproteobacteria,2MF5C@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2177
DTH2_k127_8084612_5	1123377.AUIV01000021_gene2538	2.12e-32	131.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,1RYRE@1236|Gammaproteobacteria,1X4DI@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
DTH2_k127_8088084_12	694431.DESACE_06665	1.632e-17	83.0	COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2WJ8Z@28221|Deltaproteobacteria,2M6DP@213113|Desulfurellales	28221|Deltaproteobacteria	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH2_k127_8088084_5	573370.DMR_17610	8.389e-61	212.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MBEZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Desulfoferrodoxin ferrous iron-binding region	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
DTH2_k127_8088084_7	1304885.AUEY01000003_gene491	2.686e-53	194.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MK9C@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Iron-storage protein	ftn	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
DTH2_k127_8088084_8	1232437.KL661985_gene3573	5.659e-35	139.0	COG1633@1|root,COG1633@2|Bacteria,1N36M@1224|Proteobacteria,42UVX@68525|delta/epsilon subdivisions,2WQ53@28221|Deltaproteobacteria,2MMYP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_8088084_4	865861.AZSU01000001_gene356	6.735e-64	232.0	COG4658@1|root,COG4658@2|Bacteria,1V08Y@1239|Firmicutes,24DPB@186801|Clostridia,36R19@31979|Clostridiaceae	186801|Clostridia	C	NQR2, RnfD, RnfE family	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
DTH2_k127_8088084_11	771875.Ferpe_0908	3.543e-21	102.0	COG2869@1|root,COG2869@2|Bacteria,2GCZN@200918|Thermotogae	200918|Thermotogae	C	PFAM FMN-binding domain	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
DTH2_k127_8088084_3	771875.Ferpe_0909	4.577e-65	229.0	COG1347@1|root,COG1347@2|Bacteria,2GCJ2@200918|Thermotogae	200918|Thermotogae	C	Belongs to the NqrDE RnfAE family	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
DTH2_k127_8088084_2	865861.AZSU01000001_gene359	1.649e-69	242.0	COG2209@1|root,COG2209@2|Bacteria,1UYUQ@1239|Firmicutes,24CMI@186801|Clostridia,36RAD@31979|Clostridiaceae	186801|Clostridia	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
DTH2_k127_8088084_1	573413.Spirs_0598	1.918e-112	373.0	COG2871@1|root,COG2871@2|Bacteria,2JBKD@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
DTH2_k127_8088084_9	573413.Spirs_0599	4.133e-30	124.0	2B4IF@1|root,31XAC@2|Bacteria,2JAGS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8088084_10	1219084.AP014508_gene922	1.782e-23	99.0	COG1773@1|root,COG1773@2|Bacteria,2GDE5@200918|Thermotogae	200918|Thermotogae	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
DTH2_k127_8088084_0	1499967.BAYZ01000095_gene4213	1.474e-161	523.0	COG0364@1|root,COG0364@2|Bacteria,2NNUR@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iIT341.HP1101	G6PD_C,G6PD_N
DTH2_k127_8088084_6	323261.Noc_1412	1.249e-55	201.0	28NM7@1|root,2ZBMT@2|Bacteria,1R9Y9@1224|Proteobacteria,1S227@1236|Gammaproteobacteria,1X0Q2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2959)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
DTH2_k127_8088084_13	907348.TresaDRAFT_1887	5.767e-06	57.0	COG0795@1|root,COG0795@2|Bacteria,2J64B@203691|Spirochaetes	203691|Spirochaetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
DTH2_k127_8096338_0	1048339.KB913029_gene3534	4.563e-161	517.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4ERC5@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DTH2_k127_8096338_1	1142394.PSMK_01490	1.255e-06	55.0	COG0457@1|root,COG0457@2|Bacteria	1142394.PSMK_01490|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_809773_0	313628.LNTAR_19557	6.783e-97	323.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	dctP	-	-	-	-	-	-	-	-	-	-	-	DctP
DTH2_k127_809773_2	1521187.JPIM01000048_gene92	9.875e-60	212.0	COG0225@1|root,COG0225@2|Bacteria,2G6JK@200795|Chloroflexi,375KD@32061|Chloroflexia	32061|Chloroflexia	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
DTH2_k127_809773_1	42565.FP66_15175	1.1e-82	281.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1XIBE@135619|Oceanospirillales	135619|Oceanospirillales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
DTH2_k127_8143183_5	794903.OPIT5_07560	8.376e-31	131.0	COG2211@1|root,COG2211@2|Bacteria,46YMU@74201|Verrucomicrobia,3K7KX@414999|Opitutae	414999|Opitutae	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
DTH2_k127_8143183_4	1499967.BAYZ01000075_gene2067	7.573e-39	149.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	ydaG	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx,Pyrid_ox_like
DTH2_k127_8143183_2	1499967.BAYZ01000075_gene2068	1.853e-141	455.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
DTH2_k127_8143183_0	1499967.BAYZ01000075_gene2069	1.904e-160	510.0	COG0022@1|root,COG0022@2|Bacteria,2NNQZ@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Biotin_lipoyl,Transket_pyr,Transketolase_C
DTH2_k127_8143183_3	1499967.BAYZ01000075_gene2070	1.895e-124	411.0	COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria	2|Bacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DTH2_k127_8143183_1	880073.Calab_0640	2.509e-149	482.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	SSF
DTH2_k127_8162213_0	1122963.AUHB01000009_gene1733	3.7e-202	638.0	COG1486@1|root,COG1486@2|Bacteria,1NI6G@1224|Proteobacteria,2U4JN@28211|Alphaproteobacteria,370N6@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
DTH2_k127_8162213_1	1265505.ATUG01000001_gene3328	3.352e-22	109.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,42RM3@68525|delta/epsilon subdivisions,2WNTS@28221|Deltaproteobacteria,2MK93@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529,ko:K03435	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
DTH2_k127_8162213_3	1292035.H476_2464	2.103e-05	56.0	COG1725@1|root,COG1725@2|Bacteria,1V743@1239|Firmicutes,24J7Q@186801|Clostridia,25RXB@186804|Peptostreptococcaceae	186801|Clostridia	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
DTH2_k127_8162213_2	682795.AciX8_0946	6.155e-18	98.0	COG1874@1|root,COG1874@2|Bacteria,3Y6EF@57723|Acidobacteria,2JKVE@204432|Acidobacteriia	204432|Acidobacteriia	G	Domain of unknown function (DUF4832)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4832
DTH2_k127_8169037_0	439235.Dalk_3047	4.27e-45	180.0	COG4908@1|root,COG4908@2|Bacteria,1P16I@1224|Proteobacteria	1224|Proteobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8173468_0	945713.IALB_2490	3.962e-216	687.0	COG0367@1|root,COG0367@2|Bacteria	2|Bacteria	E	asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
DTH2_k127_8173468_1	316067.Geob_2951	9.201e-161	522.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ00@28221|Deltaproteobacteria,43UQW@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
DTH2_k127_8173468_2	290397.Adeh_2788	7.497e-109	362.0	COG0171@1|root,COG0171@2|Bacteria,1QHZ4@1224|Proteobacteria,42QD8@68525|delta/epsilon subdivisions,2WMK9@28221|Deltaproteobacteria,2YZFC@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
DTH2_k127_8262915_2	1047013.AQSP01000114_gene688	2.849e-20	91.0	COG1669@1|root,COG1669@2|Bacteria,2NRII@2323|unclassified Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
DTH2_k127_8262915_1	1499967.BAYZ01000194_gene3127	6.464e-65	230.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
DTH2_k127_8262915_0	1191523.MROS_1676	5.192e-135	438.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
DTH2_k127_8348487_11	1142394.PSMK_18500	9.429e-59	214.0	COG1624@1|root,COG1624@2|Bacteria,2IZSP@203682|Planctomycetes	203682|Planctomycetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
DTH2_k127_8348487_6	1142394.PSMK_01830	3.075e-85	288.0	COG1137@1|root,COG1137@2|Bacteria,2IYUP@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type (unclassified) transport system ATPase	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
DTH2_k127_8348487_15	158189.SpiBuddy_2286	4.699e-36	143.0	COG0242@1|root,COG0242@2|Bacteria,2J7X0@203691|Spirochaetes	203691|Spirochaetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
DTH2_k127_8348487_8	398767.Glov_3217	3.259e-66	237.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2WKMK@28221|Deltaproteobacteria,43TH3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
DTH2_k127_8348487_14	880073.Calab_1349	9.272e-39	150.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DTH2_k127_8348487_3	324057.Pjdr2_3567	3.095e-123	437.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
DTH2_k127_8348487_17	97139.C824_03765	1.031e-06	63.0	COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,247SW@186801|Clostridia,36MAZ@31979|Clostridiaceae	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
DTH2_k127_8348487_7	1185876.BN8_04770	8.429e-84	293.0	COG0673@1|root,COG0673@2|Bacteria,4NGHJ@976|Bacteroidetes,47K7H@768503|Cytophagia	976|Bacteroidetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DTH2_k127_8348487_5	1089551.KE386572_gene298	1.606e-103	343.0	COG1082@1|root,COG1082@2|Bacteria,1QYE4@1224|Proteobacteria,2TXTQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DTH2_k127_8348487_10	583355.Caka_2815	1.412e-62	225.0	COG2207@1|root,COG2207@2|Bacteria,46STY@74201|Verrucomicrobia,3KA3Q@414999|Opitutae	74201|Verrucomicrobia	K	Transcriptional regulator with PAS PAC sensors, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PAS_4
DTH2_k127_8348487_13	404380.Gbem_2373	4.625e-53	192.0	COG0778@1|root,COG0778@2|Bacteria,1REJI@1224|Proteobacteria,42RKQ@68525|delta/epsilon subdivisions,2WNPF@28221|Deltaproteobacteria,43UVH@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DTH2_k127_8348487_16	1192034.CAP_3084	2.708e-13	79.0	COG3428@1|root,COG3428@2|Bacteria,1Q645@1224|Proteobacteria,435EH@68525|delta/epsilon subdivisions,2WZS7@28221|Deltaproteobacteria,2Z2MQ@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
DTH2_k127_8348487_4	886293.Sinac_5983	1.518e-110	372.0	COG1160@1|root,COG1160@2|Bacteria,2IWXY@203682|Planctomycetes	203682|Planctomycetes	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
DTH2_k127_8348487_0	177437.HRM2_21730	1.571e-188	605.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria,2MIM6@213118|Desulfobacterales	28221|Deltaproteobacteria	T	5TM C-terminal transporter carbon starvation CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
DTH2_k127_8348487_12	530564.Psta_0111	1.252e-54	220.0	COG1452@1|root,COG1452@2|Bacteria,2IXFV@203682|Planctomycetes	203682|Planctomycetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	OstA_C
DTH2_k127_8348487_1	416591.Tlet_1891	3.293e-130	422.0	COG0191@1|root,COG0191@2|Bacteria,2GC6U@200918|Thermotogae	200918|Thermotogae	G	Fructose-1,6-bisphosphate aldolase, class II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
DTH2_k127_8348487_9	1142394.PSMK_15360	1.054e-64	248.0	COG0793@1|root,COG0793@2|Bacteria,2IX9Q@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
DTH2_k127_8348487_2	247490.KSU1_C0464	2.704e-127	417.0	COG1190@1|root,COG1190@2|Bacteria,2IXHX@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DTH2_k127_8382695_0	1379281.AVAG01000029_gene21	5.005e-74	257.0	COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2WIQ8@28221|Deltaproteobacteria,2M7ZH@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	PFAM MotA TolQ ExbB proton channel	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
DTH2_k127_8382695_3	1379858.N508_00202	3.773e-13	78.0	COG1360@1|root,COG1360@2|Bacteria,2GEMA@200930|Deferribacteres	200930|Deferribacteres	N	Membrane MotB of proton-channel complex MotA/MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
DTH2_k127_8382695_4	1353529.M899_2717	1.27e-11	74.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2WKIT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
DTH2_k127_8382695_1	444158.MmarC6_0355	5.9e-45	172.0	arCOG06621@1|root,arCOG06621@2157|Archaea,2Y3GZ@28890|Euryarchaeota,23RKE@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8382695_2	264198.Reut_A0164	1.501e-13	78.0	COG0735@1|root,COG0735@2|Bacteria,1NCW6@1224|Proteobacteria,2VVWI@28216|Betaproteobacteria,1K9G1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
DTH2_k127_8382695_5	886293.Sinac_4186	3.346e-07	63.0	COG1783@1|root,COG1783@2|Bacteria	2|Bacteria	S	DNA packaging	-	-	-	ko:K06909	-	-	-	-	ko00000	-	-	-	Terminase_3,Terminase_6
DTH2_k127_8405720_1	338966.Ppro_3278	9.594e-103	346.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,43BJA@68525|delta/epsilon subdivisions,2WME6@28221|Deltaproteobacteria,43TIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
DTH2_k127_8405720_5	58344.JOEL01000044_gene886	0.0001273	45.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
DTH2_k127_8405720_4	1210884.HG799463_gene9592	1.56e-07	60.0	COG0582@1|root,COG0582@2|Bacteria,2IYXX@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
DTH2_k127_8405720_2	235909.GK1906	5.014e-88	296.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,4H9W0@91061|Bacilli,1WF2D@129337|Geobacillus	91061|Bacilli	G	Class II Aldolase and Adducin N-terminal domain	araD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
DTH2_k127_8405720_3	794903.OPIT5_28305	4.156e-12	70.0	COG1069@1|root,COG1069@2|Bacteria,46UI3@74201|Verrucomicrobia,3K769@414999|Opitutae	414999|Opitutae	G	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
DTH2_k127_8405720_0	927658.AJUM01000037_gene2251	8.502e-228	714.0	COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,2FMIU@200643|Bacteroidia,3XJ54@558415|Marinilabiliaceae	976|Bacteroidetes	G	L-arabinose isomerase	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
DTH2_k127_8455792_2	1396141.BATP01000057_gene3046	3.151e-06	52.0	2AVZM@1|root,31MU0@2|Bacteria,46X67@74201|Verrucomicrobia,2IUMV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8455792_0	1121957.ATVL01000008_gene4299	7.837e-59	218.0	COG0707@1|root,COG0707@2|Bacteria,4PKSS@976|Bacteroidetes,47NVZ@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3
DTH2_k127_8455792_1	1390370.O203_18770	8.797e-50	184.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1YJUT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
DTH2_k127_848250_2	1146883.BLASA_0843	2.509e-30	132.0	COG1536@1|root,COG1536@2|Bacteria,2GP1H@201174|Actinobacteria,4ES35@85013|Frankiales	201174|Actinobacteria	N	flagellar motor switch protein FliG	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
DTH2_k127_848250_0	237368.SCABRO_00039	2.115e-53	207.0	COG1766@1|root,COG1766@2|Bacteria,2IZ2B@203682|Planctomycetes	203682|Planctomycetes	NU	Flagellar M-ring protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	YscJ_FliF,YscJ_FliF_C
DTH2_k127_848250_5	237368.SCABRO_00038	3.885e-10	64.0	COG1677@1|root,COG1677@2|Bacteria,2J1P2@203682|Planctomycetes	203682|Planctomycetes	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
DTH2_k127_848250_3	381764.Fnod_1715	8.736e-29	120.0	COG1558@1|root,COG1558@2|Bacteria,2GCYU@200918|Thermotogae	200918|Thermotogae	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
DTH2_k127_848250_6	1380390.JIAT01000009_gene1755	4.35e-10	66.0	COG1815@1|root,COG1815@2|Bacteria,2IQWB@201174|Actinobacteria,4CSXK@84995|Rubrobacteria	84995|Rubrobacteria	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	-	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
DTH2_k127_848250_1	886293.Sinac_5016	3.305e-42	162.0	COG1595@1|root,COG1595@2|Bacteria,2IZ91@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DTH2_k127_8501445_1	935948.KE386494_gene173	3.185e-203	642.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,42F1I@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Glutamine synthetase, catalytic	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
DTH2_k127_8501445_0	573413.Spirs_2327	0.0	1242.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2J5WW@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DTH2_k127_8537522_0	583355.Caka_3034	8.272e-93	317.0	COG2805@1|root,COG2805@2|Bacteria,46S5Q@74201|Verrucomicrobia,3K79X@414999|Opitutae	414999|Opitutae	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DTH2_k127_8537522_2	158190.SpiGrapes_2087	4.216e-55	199.0	COG2344@1|root,COG2344@2|Bacteria,2J67B@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
DTH2_k127_8537522_4	573370.DMR_07850	2.884e-10	63.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,42U8S@68525|delta/epsilon subdivisions,2WQ8V@28221|Deltaproteobacteria,2MAD2@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE-1	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
DTH2_k127_8541419_3	1123242.JH636434_gene3388	1.018e-21	108.0	COG4219@1|root,COG4932@1|root,COG4219@2|Bacteria,COG4932@2|Bacteria,2IZ9V@203682|Planctomycetes	203682|Planctomycetes	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
DTH2_k127_8541419_0	177437.HRM2_23770	3.613e-121	403.0	COG4656@1|root,COG4656@2|Bacteria,1PJE1@1224|Proteobacteria,42P69@68525|delta/epsilon subdivisions,2WIM9@28221|Deltaproteobacteria,2MI2H@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
DTH2_k127_8541419_1	1121405.dsmv_3376	3.771e-79	275.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42QE5@68525|delta/epsilon subdivisions,2WM8R@28221|Deltaproteobacteria,2MIQP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
DTH2_k127_8541419_4	765913.ThidrDRAFT_1959	1.787e-05	54.0	COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria,1WXWE@135613|Chromatiales	135613|Chromatiales	U	Part of a membrane complex involved in electron transport	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
DTH2_k127_8541419_2	879212.DespoDRAFT_02017	1.261e-52	192.0	COG4660@1|root,COG4660@2|Bacteria,1R4EB@1224|Proteobacteria,42PW0@68525|delta/epsilon subdivisions,2WKTN@28221|Deltaproteobacteria,2MJEI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NqrDE RnfAE family	-	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
DTH2_k127_8560430_1	344747.PM8797T_30474	1.716e-55	205.0	COG1283@1|root,COG1283@2|Bacteria,2J2H6@203682|Planctomycetes	203682|Planctomycetes	P	COG1283 Na phosphate symporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
DTH2_k127_8560430_0	316067.Geob_0375	0.0	1660.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,43TSH@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	por	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
DTH2_k127_8560430_2	1142394.PSMK_22330	1.561e-52	205.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
DTH2_k127_8560430_4	1142394.PSMK_22340	4.219e-35	147.0	COG1269@1|root,COG1269@2|Bacteria,2IZU8@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
DTH2_k127_8560430_6	1142394.PSMK_22340	5.162e-12	76.0	COG1269@1|root,COG1269@2|Bacteria,2IZU8@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
DTH2_k127_8560430_5	5911.EAR82286	6.62e-21	110.0	COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
DTH2_k127_8560430_3	1121456.ATVA01000012_gene2942	1.251e-43	182.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2M8NV@213115|Desulfovibrionales	28221|Deltaproteobacteria	DM	PFAM lipopolysaccharide biosynthesis protein	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
DTH2_k127_8560430_7	877421.AUJT01000033_gene3404	0.0004828	44.0	COG0451@1|root,COG0451@2|Bacteria,1TS59@1239|Firmicutes,247JP@186801|Clostridia,27TI5@186928|unclassified Lachnospiraceae	186801|Clostridia	GM	Male sterility protein	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
DTH2_k127_8595764_0	1173028.ANKO01000250_gene2401	1.222e-139	449.0	COG0399@1|root,COG0399@2|Bacteria,1G0XH@1117|Cyanobacteria,1H93R@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
DTH2_k127_8595764_1	99598.Cal7507_5897	1.432e-78	286.0	COG1216@1|root,COG1216@2|Bacteria,1G346@1117|Cyanobacteria,1HIR4@1161|Nostocales	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH2_k127_8645990_0	401526.TcarDRAFT_2138	1.82e-151	491.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,4H2V3@909932|Negativicutes	909932|Negativicutes	N	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DTH2_k127_8645990_1	635013.TherJR_1540	8.285e-07	58.0	COG1317@1|root,COG1317@2|Bacteria,1VEUV@1239|Firmicutes,24QUG@186801|Clostridia,262Y4@186807|Peptococcaceae	186801|Clostridia	N	PFAM Flagellar assembly protein FliH Type III secretion system HrpE	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
DTH2_k127_8673468_0	517418.Ctha_1990	1.709e-82	289.0	COG1169@1|root,COG1169@2|Bacteria,1FDKT@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the conversion of chorismate to isochorismate	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
DTH2_k127_8673468_1	29730.Gorai.005G148400.1	4.824e-18	86.0	COG0147@1|root,COG0596@1|root,KOG1223@2759|Eukaryota,KOG2382@2759|Eukaryota,37RRC@33090|Viridiplantae,3GENA@35493|Streptophyta	35493|Streptophyta	E	Protein PHYLLO, chloroplastic	-	GO:0006732,GO:0006766,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010109,GO:0019222,GO:0031323,GO:0042180,GO:0042181,GO:0042372,GO:0042374,GO:0042548,GO:0042550,GO:0043467,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050789,GO:0050794,GO:0051186,GO:0051188,GO:0065007,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.2.1.9,4.2.1.113,4.2.99.20,5.4.4.2	ko:K14759	ko00130,ko01100,ko01110,map00130,map01100,map01110	-	R01717,R04031,R08165,R08166	RC00588,RC01053,RC02148,RC02186,RC02475	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,MR_MLE_C,TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
DTH2_k127_8709752_0	1162668.LFE_1347	3.431e-125	413.0	COG3547@1|root,COG3547@2|Bacteria,3J1BE@40117|Nitrospirae	40117|Nitrospirae	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
DTH2_k127_8709752_1	635013.TherJR_0853	1.326e-60	214.0	COG1294@1|root,COG1294@2|Bacteria,1TRYV@1239|Firmicutes,24CPA@186801|Clostridia,261EQ@186807|Peptococcaceae	186801|Clostridia	C	oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
DTH2_k127_8719178_2	1396141.BATP01000051_gene3312	1.83e-08	65.0	COG3209@1|root,COG3266@1|root,COG3209@2|Bacteria,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,MucBP,Phospholip_A2_3,YSIRK_signal
DTH2_k127_8719178_1	697281.Mahau_1771	3.61e-98	334.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_8719178_0	1291050.JAGE01000001_gene590	7.223e-103	355.0	COG3345@1|root,COG3345@2|Bacteria,1U52C@1239|Firmicutes,25FA2@186801|Clostridia,3WJWC@541000|Ruminococcaceae	186801|Clostridia	G	Alpha galactosidase A	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	CBM_6,Dockerin_1,Melibiase_2,Melibiase_2_C
DTH2_k127_8769456_2	649638.Trad_0907	1.297e-66	233.0	COG4284@1|root,COG4284@2|Bacteria	2|Bacteria	G	Utp--glucose-1-phosphate uridylyltransferase	CP_1013	-	2.7.7.23,2.7.7.83	ko:K00972,ko:K11442	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00361,M00362	R00416	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
DTH2_k127_8769456_1	886293.Sinac_5248	1.366e-89	315.0	COG2804@1|root,COG2804@2|Bacteria,2IXVD@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE
DTH2_k127_8769456_0	573413.Spirs_2429	1.388e-127	413.0	COG0190@1|root,COG0190@2|Bacteria,2J5PR@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
DTH2_k127_8769456_3	552811.Dehly_0812	1.482e-22	96.0	COG2759@1|root,COG2759@2|Bacteria,2G5QS@200795|Chloroflexi,34CK8@301297|Dehalococcoidia	301297|Dehalococcoidia	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
DTH2_k127_8797803_0	237368.SCABRO_01083	8.498e-292	903.0	COG0008@1|root,COG0008@2|Bacteria,2IYSE@203682|Planctomycetes	203682|Planctomycetes	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
DTH2_k127_8797803_9	670487.Ocepr_1599	6.507e-31	126.0	COG0203@1|root,COG0203@2|Bacteria,1WK7W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
DTH2_k127_8797803_1	1142394.PSMK_23760	1.042e-115	381.0	COG0202@1|root,COG0202@2|Bacteria,2IXPQ@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
DTH2_k127_8797803_4	768704.Desmer_0273	2.073e-59	212.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,260U9@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
DTH2_k127_8797803_5	1210884.HG799465_gene12004	1.932e-50	182.0	COG0100@1|root,COG0100@2|Bacteria,2IZCP@203682|Planctomycetes	203682|Planctomycetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
DTH2_k127_8797803_7	344747.PM8797T_12303	2.5e-43	161.0	COG0099@1|root,COG0099@2|Bacteria,2IZK8@203682|Planctomycetes	203682|Planctomycetes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
DTH2_k127_8797803_10	626418.bglu_1g02800	5.627e-14	72.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,2VXPQ@28216|Betaproteobacteria,1KB36@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
DTH2_k127_8797803_8	1123371.ATXH01000034_gene773	1.09e-31	124.0	COG0361@1|root,COG0361@2|Bacteria,2GI0P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
DTH2_k127_8797803_2	886293.Sinac_0465	6.734e-82	280.0	COG0024@1|root,COG0024@2|Bacteria,2IXPX@203682|Planctomycetes	203682|Planctomycetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DTH2_k127_8797803_3	483218.BACPEC_03165	1.686e-63	224.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,268PU@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
DTH2_k127_8797803_6	344747.PM8797T_12288	1.272e-47	175.0	COG0201@1|root,COG0201@2|Bacteria,2IXN6@203682|Planctomycetes	203682|Planctomycetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
DTH2_k127_8806050_1	555779.Dthio_PD3223	5.367e-52	195.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WIT3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM dihydropteroate synthase, DHPS	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
DTH2_k127_8806050_2	756499.Desde_2253	1.715e-47	176.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260DA@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
DTH2_k127_8806050_0	247490.KSU1_C1278	2.268e-135	442.0	COG0527@1|root,COG0527@2|Bacteria,2IY8N@203682|Planctomycetes	203682|Planctomycetes	E	aspartate kinase, monofunctional class	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
DTH2_k127_8806050_6	163908.KB235896_gene2487	1.281e-11	76.0	COG0457@1|root,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
DTH2_k127_8806050_4	1185653.A1A1_04047	6.507e-25	111.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,4HIR4@91061|Bacilli,26F8J@186818|Planococcaceae	91061|Bacilli	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
DTH2_k127_8806050_3	237368.SCABRO_03862	1.202e-37	145.0	COG1259@1|root,COG1259@2|Bacteria,2IZNE@203682|Planctomycetes	203682|Planctomycetes	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
DTH2_k127_8806050_5	1499967.BAYZ01000001_gene5910	5.419e-24	107.0	COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
DTH2_k127_8838838_0	290397.Adeh_3452	5.82e-83	289.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YUQI@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH2_k127_8841441_4	563192.HMPREF0179_03454	1.554e-06	52.0	arCOG05185@1|root,2Z9G9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8841441_3	686340.Metal_0534	1.385e-28	124.0	2E047@1|root,2ZJQK@2|Bacteria,1RA4Q@1224|Proteobacteria,1S2V2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8841441_1	247490.KSU1_D0957	3.487e-98	332.0	COG0232@1|root,COG0232@2|Bacteria,2IX8F@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
DTH2_k127_8841441_2	608538.HTH_1545	1.01e-49	182.0	COG0537@1|root,COG0537@2|Bacteria,2G43E@200783|Aquificae	200783|Aquificae	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
DTH2_k127_8841441_0	562970.Btus_1022	6.496e-184	583.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,4H9ZG@91061|Bacilli,2798V@186823|Alicyclobacillaceae	91061|Bacilli	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	M00019,M00570,M00582	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ILVD_EDD
DTH2_k127_8857250_2	1123508.JH636440_gene2214	2.217e-21	98.0	COG1520@1|root,COG1520@2|Bacteria,2IYZY@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
DTH2_k127_8857250_1	1210884.HG799464_gene11025	4.478e-33	137.0	COG1520@1|root,COG1520@2|Bacteria,2IYZY@203682|Planctomycetes	203682|Planctomycetes	S	protein kinase related protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
DTH2_k127_8857250_0	1203550.HMPREF1475_00695	2.331e-115	397.0	COG3533@1|root,COG3533@2|Bacteria,4NG7T@976|Bacteroidetes,2FPXE@200643|Bacteroidia	976|Bacteroidetes	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127
DTH2_k127_8857250_3	1120985.AUMI01000014_gene939	1.476e-05	52.0	COG2972@1|root,COG4936@1|root,COG2972@2|Bacteria,COG4936@2|Bacteria,1TSF9@1239|Firmicutes,4H3JX@909932|Negativicutes	909932|Negativicutes	KT	PFAM Transcriptional regulator, histidine kinase sensor, histidine kinase internal region, ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase,PocR
DTH2_k127_888165_1	1499967.BAYZ01000050_gene2840	8.159e-105	345.0	COG0701@1|root,COG0701@2|Bacteria,2NP6A@2323|unclassified Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
DTH2_k127_888165_5	443143.GM18_2397	3.927e-21	96.0	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DTH2_k127_888165_6	1382305.AZUC01000063_gene3367	3.435e-05	52.0	COG3871@1|root,COG3871@2|Bacteria,1V6MX@1239|Firmicutes,4HIYZ@91061|Bacilli,26FDN@186818|Planococcaceae	91061|Bacilli	S	general stress protein	ydaG	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx,Pyrid_ox_like
DTH2_k127_888165_4	344747.PM8797T_06165	1.402e-59	218.0	COG0284@1|root,COG0284@2|Bacteria,2IXSF@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
DTH2_k127_888165_2	247490.KSU1_D0789	1.084e-95	329.0	COG0771@1|root,COG0771@2|Bacteria,2IX53@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
DTH2_k127_888165_0	452637.Oter_2886	2.862e-132	432.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia,3K8TQ@414999|Opitutae	414999|Opitutae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH2_k127_888165_3	1095769.CAHF01000005_gene1469	4.012e-82	278.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria	28216|Betaproteobacteria	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
DTH2_k127_8892113_0	945713.IALB_2433	8.795e-115	382.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
DTH2_k127_8892113_2	945713.IALB_2434	1.456e-67	234.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DTH2_k127_8892113_7	945713.IALB_2435	8.536e-29	119.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-TFIIB
DTH2_k127_8892113_4	1049564.TevJSym_aa00830	7.539e-45	168.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,1J71P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
DTH2_k127_8892113_6	999419.HMPREF1077_02763	1.959e-34	136.0	COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,2FT8J@200643|Bacteroidia,22YB1@171551|Porphyromonadaceae	976|Bacteroidetes	J	Has endoribonuclease activity on mRNA	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
DTH2_k127_8892113_5	1210884.HG799469_gene13944	2.613e-37	146.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DTH2_k127_8892113_1	886293.Sinac_1401	1.037e-80	274.0	COG1403@1|root,COG1403@2|Bacteria,2IXXW@203682|Planctomycetes	203682|Planctomycetes	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
DTH2_k127_8892113_8	697281.Mahau_2859	5.406e-17	82.0	COG0407@1|root,COG0407@2|Bacteria	697281.Mahau_2859|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8892113_3	180332.JTGN01000011_gene465	8.209e-63	231.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24IZV@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH2_k127_8894508_4	1191523.MROS_1141	1.938e-29	133.0	COG0706@1|root,COG0706@2|Bacteria	2|Bacteria	U	membrane insertase activity	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
DTH2_k127_8894508_1	246194.CHY_0006	8.372e-59	221.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,42FFQ@68295|Thermoanaerobacterales	186801|Clostridia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
DTH2_k127_8894508_2	1142394.PSMK_17230	2.016e-44	175.0	COG1716@1|root,COG2203@1|root,COG4191@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2IWYR@203682|Planctomycetes	203682|Planctomycetes	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF,GAF_2,HATPase_c,Yop-YscD_cpl
DTH2_k127_8894508_0	439235.Dalk_5076	5.561e-209	664.0	COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,42PJG@68525|delta/epsilon subdivisions,2WQ9J@28221|Deltaproteobacteria,2MMDR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Flotillin	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
DTH2_k127_8894508_3	338963.Pcar_0143	2.158e-35	142.0	29X52@1|root,30IU1@2|Bacteria,1N8YP@1224|Proteobacteria,42WWU@68525|delta/epsilon subdivisions,2WT2G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8902711_0	1121918.ARWE01000001_gene2051	8.647e-105	355.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,43S4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
DTH2_k127_8902711_4	161156.JQKW01000007_gene784	1.112e-11	69.0	COG3937@1|root,COG3937@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
DTH2_k127_8902711_5	1449350.OCH239_12650	3.762e-08	63.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2TUKE@28211|Alphaproteobacteria,4KNQH@93682|Roseivivax	28211|Alphaproteobacteria	C	Protein of unknown function (DUF3485)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
DTH2_k127_8902711_3	1209989.TepiRe1_2516	1.246e-17	89.0	COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,42HEI@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
DTH2_k127_8902711_6	314278.NB231_17033	1.604e-06	55.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,1X2G8@135613|Chromatiales	135613|Chromatiales	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
DTH2_k127_8902711_1	1142394.PSMK_00340	2.441e-25	116.0	COG0811@1|root,COG0811@2|Bacteria,2IYYI@203682|Planctomycetes	203682|Planctomycetes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
DTH2_k127_8902711_7	59538.XP_005959915.1	0.0001185	53.0	COG2304@1|root,2QPS2@2759|Eukaryota,38C6V@33154|Opisthokonta,3BE0X@33208|Metazoa,3CW49@33213|Bilateria,4803N@7711|Chordata,4955J@7742|Vertebrata,3JDQS@40674|Mammalia,4J0DB@91561|Cetartiodactyla	33208|Metazoa	T	inter-alpha-trypsin inhibitor heavy chain	ITIH3	GO:0002576,GO:0003674,GO:0004857,GO:0004866,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006887,GO:0008150,GO:0009892,GO:0009987,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0016192,GO:0019222,GO:0030141,GO:0030162,GO:0030234,GO:0030414,GO:0031089,GO:0031323,GO:0031324,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032268,GO:0032269,GO:0032940,GO:0034774,GO:0042827,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0044092,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045861,GO:0046903,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060205,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0070013,GO:0080090,GO:0097708,GO:0098772,GO:0099503	-	-	-	-	-	-	-	-	-	-	ITI_HC_C,VIT,VWA
DTH2_k127_8902711_2	1142394.PSMK_18550	8.075e-25	106.0	COG1376@1|root,COG1388@1|root,COG1376@2|Bacteria,COG1388@2|Bacteria,2J0C4@203682|Planctomycetes	203682|Planctomycetes	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
DTH2_k127_8997187_0	1210884.HG799462_gene8559	3.507e-159	517.0	COG2804@1|root,COG2804@2|Bacteria,2IXSA@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DTH2_k127_8997187_1	926692.AZYG01000034_gene2428	4.392e-43	164.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WAKZ@53433|Halanaerobiales	186801|Clostridia	S	TIGRFAM competence damage-inducible protein CinA	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
DTH2_k127_9012013_6	587753.EY04_02150	3.354e-06	55.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
DTH2_k127_9012013_1	237368.SCABRO_03842	2.395e-122	408.0	COG1538@1|root,COG1538@2|Bacteria,2IX1X@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
DTH2_k127_9012013_2	644282.Deba_2442	2.013e-86	300.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42P19@68525|delta/epsilon subdivisions,2WK00@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K19595	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.25,2.A.6.2.34,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
DTH2_k127_9012013_0	338963.Pcar_3095	0.0	1111.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TFN@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K19594	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
DTH2_k127_9012013_5	1304284.L21TH_1015	4.143e-18	85.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,36MMP@31979|Clostridiaceae	186801|Clostridia	K	Cold shock protein	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
DTH2_k127_9012013_4	1142394.PSMK_24200	2.262e-29	120.0	COG0776@1|root,COG0776@2|Bacteria,2J01P@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
DTH2_k127_9012013_3	886293.Sinac_1881	2.02e-38	162.0	COG0681@1|root,COG0681@2|Bacteria,2IYWI@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DTH2_k127_9013356_3	1142394.PSMK_28990	5.708e-90	304.0	COG0201@1|root,COG0201@2|Bacteria,2IXN6@203682|Planctomycetes	203682|Planctomycetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
DTH2_k127_9013356_15	1123309.AQYB01000023_gene872	1.365e-41	157.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli	91061|Bacilli	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
DTH2_k127_9013356_11	247490.KSU1_C1225	1.435e-47	175.0	COG0098@1|root,COG0098@2|Bacteria,2IZ7J@203682|Planctomycetes	203682|Planctomycetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
DTH2_k127_9013356_18	521045.Kole_1886	1.147e-35	139.0	COG0256@1|root,COG0256@2|Bacteria,2GD32@200918|Thermotogae	200918|Thermotogae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
DTH2_k127_9013356_9	608506.COB47_0854	2.212e-50	184.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,42GCD@68295|Thermoanaerobacterales	186801|Clostridia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
DTH2_k127_9013356_14	1301100.HG529435_gene6483	8.08e-44	162.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,36I6W@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
DTH2_k127_9013356_22	1244528.CFT03427_0045	3.047e-20	91.0	COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2YQIN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
DTH2_k127_9013356_5	1392493.JIAB01000001_gene2415	2.09e-67	233.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,27IA8@186928|unclassified Lachnospiraceae	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
DTH2_k127_9013356_19	360911.EAT1b_1622	6.377e-30	122.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,3WEZB@539002|Bacillales incertae sedis	91061|Bacilli	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
DTH2_k127_9013356_16	530564.Psta_2610	1.733e-40	153.0	COG0093@1|root,COG0093@2|Bacteria,2IZMA@203682|Planctomycetes	203682|Planctomycetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
DTH2_k127_9013356_21	132113.XP_003493820.1	1.603e-20	93.0	COG0186@1|root,KOG1740@2759|Eukaryota,39GX2@33154|Opisthokonta,3C1YY@33208|Metazoa	33208|Metazoa	J	Ribosomal protein S17	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S17
DTH2_k127_9013356_24	1144343.PMI41_02381	8.385e-06	50.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,43M8I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
DTH2_k127_9013356_10	1142394.PSMK_29110	3.032e-48	176.0	COG0197@1|root,COG0197@2|Bacteria,2IZPH@203682|Planctomycetes	203682|Planctomycetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
DTH2_k127_9013356_4	1142394.PSMK_29120	8.448e-75	260.0	COG0092@1|root,COG0092@2|Bacteria,2IWWU@203682|Planctomycetes	203682|Planctomycetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
DTH2_k127_9013356_23	1142394.PSMK_29130	4.263e-16	85.0	COG0091@1|root,COG0091@2|Bacteria,2J023@203682|Planctomycetes	203682|Planctomycetes	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
DTH2_k127_9013356_17	314230.DSM3645_09382	3.679e-38	144.0	COG0185@1|root,COG0185@2|Bacteria,2J0BB@203682|Planctomycetes	203682|Planctomycetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
DTH2_k127_9013356_2	247490.KSU1_C1211	2.571e-105	348.0	COG0090@1|root,COG0090@2|Bacteria,2IXD9@203682|Planctomycetes	203682|Planctomycetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
DTH2_k127_9013356_20	383372.Rcas_4024	1.063e-22	100.0	COG0089@1|root,COG0089@2|Bacteria,2G73T@200795|Chloroflexi,375Y1@32061|Chloroflexia	32061|Chloroflexia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
DTH2_k127_9013356_12	649747.HMPREF0083_05156	9.239e-47	175.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,26S1U@186822|Paenibacillaceae	91061|Bacilli	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
DTH2_k127_9013356_6	247490.KSU1_C1208	1.101e-60	216.0	COG0087@1|root,COG0087@2|Bacteria,2IY9T@203682|Planctomycetes	203682|Planctomycetes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
DTH2_k127_9013356_13	1142394.PSMK_29190	1.911e-45	166.0	COG0051@1|root,COG0051@2|Bacteria,2IZQR@203682|Planctomycetes	203682|Planctomycetes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
DTH2_k127_9013356_0	289376.THEYE_A1449	1.08e-242	767.0	COG0480@1|root,COG0480@2|Bacteria,3J0EK@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DTH2_k127_9013356_7	247490.KSU1_C1204	3.143e-58	205.0	COG0049@1|root,COG0049@2|Bacteria,2IZ7I@203682|Planctomycetes	203682|Planctomycetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
DTH2_k127_9013356_8	697281.Mahau_2161	1.838e-53	190.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,42GED@68295|Thermoanaerobacterales	186801|Clostridia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
DTH2_k127_9013356_1	886293.Sinac_0499	8.919e-231	730.0	COG0086@1|root,COG0086@2|Bacteria,2IXGN@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DTH2_k127_9024389_1	402777.KB235903_gene2495	5.491e-05	54.0	COG3271@1|root,COG3271@2|Bacteria,1G4RJ@1117|Cyanobacteria,1H8V3@1150|Oscillatoriales	1117|Cyanobacteria	S	Peptidase C39 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39
DTH2_k127_9024389_0	1521187.JPIM01000050_gene3445	1.972e-144	466.0	COG0542@1|root,COG0542@2|Bacteria,2G5QU@200795|Chloroflexi,3758N@32061|Chloroflexia	32061|Chloroflexia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
DTH2_k127_9035532_1	1232410.KI421418_gene2157	2.251e-64	224.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43UCA@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
DTH2_k127_9035532_2	592029.DDD_0379	2.707e-36	140.0	2CCSR@1|root,32RWC@2|Bacteria,4NUMI@976|Bacteroidetes,1I4SZ@117743|Flavobacteriia	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
DTH2_k127_9035532_0	391625.PPSIR1_25856	3.886e-67	244.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales	28221|Deltaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
DTH2_k127_9035532_3	553217.ENHAE0001_2393	2.539e-33	134.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,3NN5T@468|Moraxellaceae	1236|Gammaproteobacteria	U	general secretion pathway protein	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
DTH2_k127_9037315_0	697281.Mahau_2857	5.168e-127	416.0	COG0407@1|root,COG0407@2|Bacteria,1V2TK@1239|Firmicutes,24FVW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH2_k127_9037315_2	237368.SCABRO_02293	2.081e-51	203.0	COG0457@1|root,COG0457@2|Bacteria,2IZWD@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8,Transglut_core2
DTH2_k127_9037315_3	395961.Cyan7425_4156	3.219e-16	81.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	CP_0257	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
DTH2_k127_9037315_1	338966.Ppro_2629	5.809e-60	213.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,43TBH@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DTH2_k127_9084444_4	1121405.dsmv_0452	2.16e-32	133.0	COG3090@1|root,COG3090@2|Bacteria,1REB9@1224|Proteobacteria,42RXU@68525|delta/epsilon subdivisions,2WNAT@28221|Deltaproteobacteria,2MJSJ@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
DTH2_k127_9084444_1	879212.DespoDRAFT_00416	2.475e-141	456.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42M8Y@68525|delta/epsilon subdivisions,2WIZG@28221|Deltaproteobacteria,2MJ36@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
DTH2_k127_9084444_2	868864.Dester_1081	2.541e-124	411.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
DTH2_k127_9084444_3	243231.GSU1738	2.395e-54	198.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,43TA9@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
DTH2_k127_9084444_0	349161.Dred_3189	2.101e-197	633.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
DTH2_k127_9109958_0	247490.KSU1_D0953	3.601e-47	188.0	COG0681@1|root,COG0681@2|Bacteria,2IYWI@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DTH2_k127_9134367_1	491952.Mar181_1640	7.111e-102	339.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XHH6@135619|Oceanospirillales	135619|Oceanospirillales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF-1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
DTH2_k127_9134367_2	483219.LILAB_32515	7.822e-72	252.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,2YVC9@29|Myxococcales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
DTH2_k127_9134367_0	908338.HMPREF9286_0669	1.359e-123	406.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,22GA4@1570339|Peptoniphilaceae	186801|Clostridia	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
DTH2_k127_9139653_6	767817.Desgi_2181	1.798e-28	117.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,261IR@186807|Peptococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
DTH2_k127_9139653_7	5911.EAR82286	5.555e-27	125.0	COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
DTH2_k127_9139653_4	1123511.KB905844_gene1242	5.622e-57	202.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4H3ZR@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
DTH2_k127_9139653_8	756499.Desde_2942	4.981e-26	113.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,26201@186807|Peptococcaceae	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
DTH2_k127_9139653_2	314230.DSM3645_12121	2.194e-83	287.0	COG1192@1|root,COG1192@2|Bacteria,2IX5Z@203682|Planctomycetes	203682|Planctomycetes	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
DTH2_k127_9139653_5	1267535.KB906767_gene720	3.003e-39	157.0	COG0760@1|root,COG0760@2|Bacteria,3Y8EB@57723|Acidobacteria,2JNN9@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM PPIC-type	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
DTH2_k127_9139653_3	484018.BACPLE_01017	9.497e-68	245.0	2FB4Y@1|root,343B9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9139653_0	1122925.KB895381_gene3889	4.603e-218	698.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,4HB1D@91061|Bacilli,26TU3@186822|Paenibacillaceae	91061|Bacilli	G	Domain of unknown function (DUF5110)	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,DUF5110,F5_F8_type_C,Gal_mutarotas_2,Glyco_hydro_31
DTH2_k127_9139653_1	1232410.KI421416_gene2699	1.194e-182	587.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,42MQD@68525|delta/epsilon subdivisions,2WJJP@28221|Deltaproteobacteria,43UUZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Sulfate permease family	ychM	-	4.2.1.1	ko:K01673,ko:K03321	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000,ko02000	2.A.53.3	-	-	Pro_CA,STAS,STAS_2,Sulfate_transp
DTH2_k127_9167055_1	247490.KSU1_C0203	3.373e-114	378.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DTH2_k127_9167055_4	443143.GM18_1937	7.022e-79	275.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,43SCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
DTH2_k127_9167055_3	357808.RoseRS_3990	1.221e-83	286.0	COG2084@1|root,COG2084@2|Bacteria,2G6B3@200795|Chloroflexi,376B1@32061|Chloroflexia	32061|Chloroflexia	I	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
DTH2_k127_9167055_5	1313304.CALK_1925	6.254e-72	250.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
DTH2_k127_9167055_7	311424.DhcVS_1273	2.463e-24	108.0	COG0239@1|root,COG0239@2|Bacteria,2G760@200795|Chloroflexi,34DD6@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
DTH2_k127_9167055_6	338966.Ppro_0834	4.573e-27	115.0	COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,42TZK@68525|delta/epsilon subdivisions,2WVSD@28221|Deltaproteobacteria,43V7C@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
DTH2_k127_9167055_0	69395.JQLZ01000009_gene1818	5.233e-124	431.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2KFVI@204458|Caulobacterales	204458|Caulobacterales	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
DTH2_k127_9167055_8	521674.Plim_2270	6.891e-07	57.0	COG3688@1|root,COG3688@2|Bacteria,2J0R8@203682|Planctomycetes	203682|Planctomycetes	S	YacP-like NYN domain	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
DTH2_k127_9167055_2	886293.Sinac_3038	6.09e-112	371.0	COG0044@1|root,COG0044@2|Bacteria,2IWS9@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
DTH2_k127_91753_0	1341151.ASZU01000001_gene683	3.698e-170	549.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,27B3H@186824|Thermoactinomycetaceae	91061|Bacilli	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
DTH2_k127_9185048_0	756272.Plabr_2931	1.155e-142	464.0	COG0304@1|root,COG0304@2|Bacteria,2IX8X@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
DTH2_k127_9185048_1	1142394.PSMK_03130	1.082e-85	299.0	COG0304@1|root,COG0304@2|Bacteria,2IY1N@203682|Planctomycetes	203682|Planctomycetes	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
DTH2_k127_9185048_2	521674.Plim_3121	1.067e-42	162.0	COG0764@1|root,COG0764@2|Bacteria,2IZWX@203682|Planctomycetes	203682|Planctomycetes	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
DTH2_k127_9185048_3	1123508.JH636443_gene5039	9.732e-15	74.0	COG0236@1|root,COG0236@2|Bacteria,2J04I@203682|Planctomycetes	203682|Planctomycetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
DTH2_k127_9188769_0	1304885.AUEY01000019_gene1167	9.015e-116	382.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,42P6V@68525|delta/epsilon subdivisions,2WM6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
DTH2_k127_9188769_1	1396418.BATQ01000104_gene5470	6.944e-19	91.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF676,Hydrolase_4,PGAP1
DTH2_k127_9199811_2	1415779.JOMH01000001_gene379	9.524e-190	599.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1X48A@135614|Xanthomonadales	135614|Xanthomonadales	J	GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DTH2_k127_9199811_8	1142394.PSMK_08320	6.074e-12	68.0	COG0267@1|root,COG0267@2|Bacteria,2J1HX@203682|Planctomycetes	203682|Planctomycetes	J	Belongs to the bacterial ribosomal protein bL33 family	-	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
DTH2_k127_9199811_9	1210884.HG799467_gene13477	2.536e-08	60.0	COG0690@1|root,COG0690@2|Bacteria,2J0E7@203682|Planctomycetes	203682|Planctomycetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
DTH2_k127_9199811_5	1142394.PSMK_08340	1.111e-57	206.0	COG0250@1|root,COG0250@2|Bacteria,2IZ9N@203682|Planctomycetes	203682|Planctomycetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
DTH2_k127_9199811_4	575540.Isop_0109	7.659e-58	203.0	COG0080@1|root,COG0080@2|Bacteria,2IZ97@203682|Planctomycetes	203682|Planctomycetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
DTH2_k127_9199811_3	247490.KSU1_C1198	4.619e-75	259.0	COG0081@1|root,COG0081@2|Bacteria,2IYQK@203682|Planctomycetes	203682|Planctomycetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DTH2_k127_9199811_7	243090.RB12840	1.333e-17	89.0	COG0244@1|root,COG0244@2|Bacteria,2J0R0@203682|Planctomycetes	203682|Planctomycetes	J	ribosomal protein l10	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
DTH2_k127_9199811_6	756272.Plabr_2007	9.248e-43	160.0	COG0222@1|root,COG0222@2|Bacteria,2J0AK@203682|Planctomycetes	203682|Planctomycetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
DTH2_k127_9199811_0	1142394.PSMK_24450	0.0	1644.0	COG0085@1|root,COG0085@2|Bacteria,2IXVZ@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
DTH2_k127_9199811_1	886293.Sinac_0499	0.0	1276.0	COG0086@1|root,COG0086@2|Bacteria,2IXGN@203682|Planctomycetes	203682|Planctomycetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DTH2_k127_9204719_1	1307759.JOMJ01000003_gene1736	6.523e-20	100.0	COG2982@1|root,COG2982@2|Bacteria,1N0N6@1224|Proteobacteria,42V8E@68525|delta/epsilon subdivisions,2WS8I@28221|Deltaproteobacteria,2MAB9@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	AsmA
DTH2_k127_9204719_0	1408423.JHYA01000005_gene1772	3.359e-90	310.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4H2P5@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
DTH2_k127_9204719_2	497964.CfE428DRAFT_1693	1.62e-06	55.0	COG0859@1|root,COG0859@2|Bacteria,46SZK@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
DTH2_k127_9220432_2	237368.SCABRO_00794	6.46e-44	163.0	COG0601@1|root,COG0601@2|Bacteria,2IYGR@203682|Planctomycetes	203682|Planctomycetes	P	transport systems	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DTH2_k127_9220432_1	1201290.M902_1885	7.885e-80	277.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DTH2_k127_9220432_0	1293054.HSACCH_00336	8.486e-91	303.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WAG7@53433|Halanaerobiales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain	-	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DTH2_k127_9229154_1	1443125.Z962_07440	5.86e-64	225.0	COG3647@1|root,COG3647@2|Bacteria,1V19Q@1239|Firmicutes,249U7@186801|Clostridia,36DSZ@31979|Clostridiaceae	186801|Clostridia	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
DTH2_k127_9229154_0	1142394.PSMK_30020	5.975e-84	293.0	COG1192@1|root,COG3170@1|root,COG1192@2|Bacteria,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496,ko:K09000	-	-	-	-	ko00000,ko02048,ko03036,ko04812	-	-	-	AAA_31
DTH2_k127_9229154_2	365046.Rta_16010	1.918e-07	61.0	COG0673@1|root,COG0673@2|Bacteria,1NKUI@1224|Proteobacteria,2VUT6@28216|Betaproteobacteria,4AJ4R@80864|Comamonadaceae	28216|Betaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DTH2_k127_9232126_3	716544.wcw_0742	5.433e-28	117.0	COG1090@1|root,COG1090@2|Bacteria,2JFV6@204428|Chlamydiae	204428|Chlamydiae	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
DTH2_k127_9232126_1	1492738.FEM21_20740	4.15e-40	154.0	COG3476@1|root,COG3476@2|Bacteria,4NP0D@976|Bacteroidetes,1I2B8@117743|Flavobacteriia,2NVX1@237|Flavobacterium	976|Bacteroidetes	T	TspO/MBR family	tspO	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
DTH2_k127_9232126_2	555779.Dthio_PD3749	4.431e-36	140.0	COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
DTH2_k127_9232126_0	335543.Sfum_2407	5.511e-60	214.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,42S14@68525|delta/epsilon subdivisions,2WNUI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
DTH2_k127_9250707_1	1089547.KB913013_gene3023	2.546e-59	213.0	COG1515@1|root,COG1515@2|Bacteria,4NI4J@976|Bacteroidetes,47KIS@768503|Cytophagia	976|Bacteroidetes	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
DTH2_k127_9250707_0	1408422.JHYF01000003_gene872	1.126e-242	767.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
DTH2_k127_9262424_1	1123242.JH636434_gene4261	2.803e-58	213.0	COG0612@1|root,COG0612@2|Bacteria,2IY7Q@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DTH2_k127_9262424_0	756272.Plabr_1963	1.703e-111	374.0	COG0612@1|root,COG0612@2|Bacteria,2IWSI@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DTH2_k127_9336344_1	338963.Pcar_0050	1.338e-168	537.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,43TEM@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DTH2_k127_9336344_5	338963.Pcar_0051	1.205e-111	367.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,43U7A@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
DTH2_k127_9336344_0	1232410.KI421413_gene795	1.505e-188	597.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria,43S7X@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY-1	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DTH2_k127_9336344_4	635013.TherJR_0217	9.064e-115	377.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,2608D@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
DTH2_k127_9336344_6	1123274.KB899413_gene738	2.037e-102	342.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
DTH2_k127_9336344_3	247490.KSU1_C0520	9.093e-132	426.0	COG0031@1|root,COG0031@2|Bacteria,2IXCX@203682|Planctomycetes	203682|Planctomycetes	E	cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH2_k127_9336344_9	1449126.JQKL01000012_gene3493	2.539e-33	134.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,269FU@186813|unclassified Clostridiales	186801|Clostridia	K	Transcriptional regulator	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DTH2_k127_9336344_10	211165.AJLN01000135_gene5737	3.578e-28	130.0	COG2244@1|root,COG2244@2|Bacteria,1FZXI@1117|Cyanobacteria,1JJ8B@1189|Stigonemataceae	1117|Cyanobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
DTH2_k127_9336344_7	593750.Metfor_2109	1.335e-78	265.0	COG2406@1|root,arCOG01093@2157|Archaea,2XWHS@28890|Euryarchaeota	28890|Euryarchaeota	S	COG2406 Protein distantly related to bacterial ferritins	dpsA2	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
DTH2_k127_9336344_8	1120985.AUMI01000001_gene2109	2.522e-54	201.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,4H2R1@909932|Negativicutes	909932|Negativicutes	EH	Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
DTH2_k127_9336344_11	324831.LGAS_0745	1.443e-22	100.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,4HIGK@91061|Bacilli,3F6WT@33958|Lactobacillaceae	91061|Bacilli	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
DTH2_k127_9336344_13	2754.EH55_03730	1.518e-06	56.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DTH2_k127_9336344_14	1136417.AZWE01000054_gene833	6.386e-06	53.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4DE05@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
DTH2_k127_9336344_2	926561.KB900620_gene2915	6.673e-132	428.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WAI0@53433|Halanaerobiales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DTH2_k127_9336344_12	867903.ThesuDRAFT_01537	9.603e-19	87.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DTH2_k127_9337286_2	1121423.JONT01000001_gene2135	3.779e-21	95.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,24R29@186801|Clostridia,26375@186807|Peptococcaceae	186801|Clostridia	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NifU
DTH2_k127_9337286_0	1123508.JH636442_gene4030	4.579e-106	351.0	COG0329@1|root,COG0329@2|Bacteria,2IXII@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
DTH2_k127_9337286_1	65093.PCC7418_2594	3.337e-27	112.0	COG0854@1|root,COG0854@2|Bacteria,1G0QW@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
DTH2_k127_9382021_0	945713.IALB_1298	8.7e-154	499.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	nagB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso,PIG-L
DTH2_k127_9382021_6	278963.ATWD01000002_gene473	1.875e-14	78.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	mdsC	-	2.7.1.162,2.7.1.39	ko:K02204,ko:K13059	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771,R08962	RC00002,RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
DTH2_k127_9382021_1	794903.OPIT5_17315	2.311e-52	196.0	COG2207@1|root,COG2207@2|Bacteria,46V2R@74201|Verrucomicrobia,3K86B@414999|Opitutae	414999|Opitutae	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
DTH2_k127_9382021_9	658659.HMPREF0983_00529	3.808e-08	64.0	COG1266@1|root,COG1266@2|Bacteria,1W74N@1239|Firmicutes,3VRE9@526524|Erysipelotrichia	526524|Erysipelotrichia	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DTH2_k127_9382021_2	4113.PGSC0003DMT400089450	6.071e-25	108.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GWDE@35493|Streptophyta,44U28@71274|asterids	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9382021_8	1410676.JNKL01000108_gene1988	9.564e-09	56.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9382021_7	1541065.JRFE01000052_gene4176	5.26e-11	64.0	2EK6X@1|root,33DXA@2|Bacteria,1GFHH@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9382021_3	498761.HM1_3148	1.109e-21	98.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9382021_5	411463.EUBVEN_00788	6.346e-16	79.0	2DPM9@1|root,332MQ@2|Bacteria,1VGFB@1239|Firmicutes,251YU@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9382021_10	1123489.AUAN01000022_gene40	1.815e-05	49.0	2ERMT@1|root,33J79@2|Bacteria,1VKZE@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9395213_0	177439.DP3024	8.476e-88	296.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42PI3@68525|delta/epsilon subdivisions,2WJN3@28221|Deltaproteobacteria,2MMSY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA pseudouridylate synthase	-	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
DTH2_k127_9395213_3	91464.S7335_2846	9.961e-13	78.0	COG1876@1|root,COG1876@2|Bacteria,1G5C6@1117|Cyanobacteria,1GYY6@1129|Synechococcus	1117|Cyanobacteria	M	D-alanyl-D-alanine carboxypeptidase	vanY	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
DTH2_k127_9395213_1	247490.KSU1_C0630	1.725e-46	177.0	COG0132@1|root,COG0132@2|Bacteria,2J026@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
DTH2_k127_9395213_2	1430331.EP10_17835	1.416e-18	93.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,1WETT@129337|Geobacillus	91061|Bacilli	K	binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription this protein is involved in detoxification and protection against antimicrobial	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DTH2_k127_9407539_3	886293.Sinac_1635	2.232e-10	65.0	COG0582@1|root,COG0582@2|Bacteria,2IYXX@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
DTH2_k127_9407539_1	411473.RUMCAL_01221	2.708e-57	202.0	COG4154@1|root,COG4154@2|Bacteria,1V402@1239|Firmicutes,24FU7@186801|Clostridia,3WJ3H@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the RbsD FucU family	fucU	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
DTH2_k127_9407539_0	756272.Plabr_1703	3.778e-70	254.0	COG0772@1|root,COG0772@2|Bacteria,2IZRI@203682|Planctomycetes	203682|Planctomycetes	D	Belongs to the SEDS family	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
DTH2_k127_9407539_4	574087.Acear_1901	1.014e-07	55.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia	186801|Clostridia	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH2_k127_9475303_0	886293.Sinac_6463	2.703e-277	868.0	COG0480@1|root,COG0480@2|Bacteria,2IXUD@203682|Planctomycetes	203682|Planctomycetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DTH2_k127_9475303_3	583355.Caka_0857	1.962e-76	274.0	COG0591@1|root,COG0591@2|Bacteria,46ZB9@74201|Verrucomicrobia,3K8WD@414999|Opitutae	414999|Opitutae	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
DTH2_k127_9475303_2	237368.SCABRO_03990	4.607e-86	297.0	COG2103@1|root,COG2103@2|Bacteria,2IWTZ@203682|Planctomycetes	203682|Planctomycetes	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	murQ	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS,SIS_2
DTH2_k127_9475303_1	247490.KSU1_C0348	5.45e-111	371.0	COG2377@1|root,COG2377@2|Bacteria,2IZ2P@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
DTH2_k127_9546312_1	1121468.AUBR01000011_gene2509	1.069e-22	110.0	COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,24A5A@186801|Clostridia,42GMT@68295|Thermoanaerobacterales	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
DTH2_k127_9546312_0	572547.Amico_1218	3.354e-45	183.0	COG1538@1|root,COG1538@2|Bacteria,3TAXQ@508458|Synergistetes	508458|Synergistetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
DTH2_k127_9546312_2	1163408.UU9_06709	4.23e-18	93.0	COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,1S401@1236|Gammaproteobacteria,1X396@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DTH2_k127_9568203_3	1123037.AUDE01000022_gene1494	1.666e-12	68.0	COG0812@1|root,COG0812@2|Bacteria,4NJ5K@976|Bacteroidetes,1I109@117743|Flavobacteriia	976|Bacteroidetes	M	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4,MurB_C
DTH2_k127_9568203_0	237368.SCABRO_03963	7.449e-274	855.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DTH2_k127_9568203_2	1168034.FH5T_07485	5.101e-104	346.0	COG3622@1|root,COG3622@2|Bacteria,4NG74@976|Bacteroidetes	976|Bacteroidetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DTH2_k127_9568203_1	452637.Oter_2975	4.063e-143	465.0	COG0673@1|root,COG0673@2|Bacteria,46UJ9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
DTH2_k127_9684082_2	439292.Bsel_1309	1.063e-17	86.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,4HF5S@91061|Bacilli	91061|Bacilli	O	Cytochrome c	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
DTH2_k127_9684082_3	1379270.AUXF01000004_gene3076	6.805e-16	82.0	COG2332@1|root,COG2332@2|Bacteria,1ZTNV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
DTH2_k127_9684082_1	880072.Desac_0396	1.133e-38	149.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,42RM4@68525|delta/epsilon subdivisions,2WNU8@28221|Deltaproteobacteria,2MS7W@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	SMART Transcription regulator, AsnC-type	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
DTH2_k127_9684082_0	330214.NIDE4293	5.853e-152	490.0	COG0001@1|root,COG0001@2|Bacteria,3J0B3@40117|Nitrospirae	40117|Nitrospirae	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH2_k127_9712368_0	237368.SCABRO_03926	3.438e-216	687.0	COG0173@1|root,COG0173@2|Bacteria,2IX6U@203682|Planctomycetes	203682|Planctomycetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
DTH2_k127_9712368_2	1166018.FAES_2948	8.141e-34	134.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,47QDT@768503|Cytophagia	976|Bacteroidetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DTH2_k127_9712368_3	74545.EU96_0790	1.193e-32	136.0	COG2928@1|root,COG2928@2|Bacteria,1G02Y@1117|Cyanobacteria,1MKK9@1212|Prochloraceae	1117|Cyanobacteria	S	Alternative locus ID	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
DTH2_k127_9712368_4	575540.Isop_1265	6.708e-29	128.0	COG1466@1|root,COG1466@2|Bacteria,2IZVJ@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase III, delta' subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
DTH2_k127_9712368_1	1379698.RBG1_1C00001G0278	9.397e-146	477.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DTH2_k127_9738671_1	717231.Flexsi_1562	2.361e-58	211.0	COG1573@1|root,COG1573@2|Bacteria,2GFD7@200930|Deferribacteres	200930|Deferribacteres	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DTH2_k127_9738671_2	1142394.PSMK_29720	6.64e-42	159.0	COG0461@1|root,COG0461@2|Bacteria,2IZA7@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
DTH2_k127_9738671_0	228405.HNE_3446	5.159e-75	267.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
DTH2_k127_9818079_0	886293.Sinac_5300	8.62e-55	197.0	COG3494@1|root,COG3494@2|Bacteria,2IXGX@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
DTH2_k127_9818079_1	344747.PM8797T_06035	2.723e-12	79.0	2E5SS@1|root,33KN4@2|Bacteria,2J1CB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9883736_1	555088.DealDRAFT_0754	6.866e-50	184.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,42JTH@68298|Syntrophomonadaceae	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
DTH2_k127_9883736_0	521674.Plim_0603	2.189e-216	678.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DTH2_k127_9885127_0	497964.CfE428DRAFT_2628	2.362e-171	567.0	COG3420@1|root,COG3420@2|Bacteria,46TGV@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
DTH2_k127_9893915_4	37659.JNLN01000001_gene1543	4.751e-14	74.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,36FVA@31979|Clostridiaceae	186801|Clostridia	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
DTH2_k127_9893915_5	4533.OB10G12750.1	2.493e-07	52.0	COG0415@1|root,KOG0133@2759|Eukaryota,37HUP@33090|Viridiplantae,3G93X@35493|Streptophyta,3KVD0@4447|Liliopsida,3ICCB@38820|Poales	35493|Streptophyta	LT	photo-lyase	PHR	GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
DTH2_k127_9893915_2	1121403.AUCV01000002_gene611	2.598e-38	148.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2WP41@28221|Deltaproteobacteria,2MK62@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
DTH2_k127_9893915_3	1168034.FH5T_19675	5.789e-21	99.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DTH2_k127_9893915_1	246197.MXAN_2697	1.766e-40	159.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WRF8@28221|Deltaproteobacteria,2Z1Y6@29|Myxococcales	28221|Deltaproteobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
DTH2_k127_9893915_0	886293.Sinac_0178	4.307e-82	282.0	COG2189@1|root,COG2189@2|Bacteria,2IWRP@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
## 1958 queries scanned
## Total time (seconds): 192.89796829223633
## Rate: 10.15 q/s