## Fri Nov 15 03:35:00 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin1/DTH_2_bin.56.fa -m mmseqs --itype genome -o DTH_2_bin.56 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/DTH_2_bin.56 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
DTH2_k127_1148607_1	243232.MJ_1498	8.945e-15	75.0	COG0863@1|root,arCOG00115@2157|Archaea,2XWB2@28890|Euryarchaeota,23RT5@183939|Methanococci	183939|Methanococci	L	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DTH2_k127_1148607_2	593750.Metfor_0279	7.625e-07	51.0	arCOG04899@1|root,arCOG04899@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1148607_0	1041930.Mtc_1486	4.769e-198	630.0	COG0591@1|root,arCOG01316@2157|Archaea,2XU91@28890|Euryarchaeota,2N973@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	iAF692.Mbar_A3721	SSF
DTH2_k127_121112_2	679926.Mpet_1523	5.54e-35	137.0	arCOG05298@1|root,arCOG05298@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_121112_0	521011.Mpal_0504	2.703e-74	254.0	COG0288@1|root,arCOG02860@2157|Archaea,2XUWI@28890|Euryarchaeota,2NB9R@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
DTH2_k127_121112_1	593750.Metfor_1657	1.09e-57	203.0	COG0129@1|root,arCOG04045@2157|Archaea,2XSW2@28890|Euryarchaeota,2N992@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2069	ILVD_EDD
DTH2_k127_1274338_2	323259.Mhun_0760	1.553e-46	175.0	COG1361@1|root,arCOG02080@2157|Archaea,2Y0I6@28890|Euryarchaeota,2N9ZF@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
DTH2_k127_1274338_0	593750.Metfor_0508	1.061e-143	467.0	COG0577@1|root,arCOG02315@2157|Archaea,2XYJU@28890|Euryarchaeota,2N9SS@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DTH2_k127_1274338_1	593750.Metfor_0509	1.173e-49	181.0	COG1136@1|root,arCOG00922@2157|Archaea,2XWHK@28890|Euryarchaeota,2N9GX@224756|Methanomicrobia	224756|Methanomicrobia	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH2_k127_1284480_0	368407.Memar_0981	2.228e-124	407.0	COG0113@1|root,arCOG04300@2157|Archaea,2XSZ8@28890|Euryarchaeota,2N97S@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
DTH2_k127_1284480_1	593750.Metfor_1097	3.047e-18	87.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
DTH2_k127_1284480_2	679926.Mpet_1529	3.72e-06	50.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,2N97X@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
DTH2_k127_130541_1	368407.Memar_0631	1.734e-108	358.0	COG2516@1|root,arCOG00662@2157|Archaea,2Y23P@28890|Euryarchaeota,2NBFM@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH2_k127_130541_0	368407.Memar_0632	3.278e-151	489.0	COG4231@1|root,arCOG01612@2157|Archaea,2XWAR@28890|Euryarchaeota,2N95R@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C,TPP_enzyme_N
DTH2_k127_130541_2	304371.MCP_1960	4.217e-33	132.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,2N9F5@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
DTH2_k127_1312461_1	593750.Metfor_0943	8.638e-87	290.0	COG0531@1|root,arCOG00009@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Trp_Tyr_perm,Usp
DTH2_k127_1312461_4	368407.Memar_1697	1.143e-78	276.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,2N9SR@224756|Methanomicrobia	224756|Methanomicrobia	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
DTH2_k127_1312461_5	679926.Mpet_0929	2.195e-38	149.0	arCOG04381@1|root,arCOG04381@2157|Archaea,2Y14T@28890|Euryarchaeota,2N9Y2@224756|Methanomicrobia	224756|Methanomicrobia	M	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
DTH2_k127_1312461_3	521011.Mpal_2542	5.062e-79	272.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,2N9TJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
DTH2_k127_1312461_0	368407.Memar_1694	2.388e-123	406.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,2N95Z@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
DTH2_k127_1312461_2	456442.Mboo_1839	7.589e-82	277.0	COG1148@1|root,arCOG02234@2157|Archaea,2Y7JF@28890|Euryarchaeota,2NBK7@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,Pyr_redox_2
DTH2_k127_1352458_9	521011.Mpal_0957	4.123e-15	78.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,2N93I@224756|Methanomicrobia	224756|Methanomicrobia	J	Translation initiation factor 2 alpha subunit	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
DTH2_k127_1352458_8	521011.Mpal_0956	5.625e-25	107.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
DTH2_k127_1352458_5	323259.Mhun_1130	1.654e-48	174.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,2N9XH@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
DTH2_k127_1352458_6	593750.Metfor_0998	1.48e-40	159.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,2N9Z3@224756|Methanomicrobia	224756|Methanomicrobia	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
DTH2_k127_1352458_2	593750.Metfor_0997	2.03e-137	447.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
DTH2_k127_1352458_0	456442.Mboo_1956	3.541e-217	685.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,2N9D5@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM histone acetyltransferase, ELP3 family	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
DTH2_k127_1352458_7	323259.Mhun_1134	1.029e-28	119.0	COG1745@1|root,arCOG02254@2157|Archaea	2157|Archaea	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
DTH2_k127_1352458_3	521011.Mpal_0950	2.875e-86	295.0	COG1397@1|root,arCOG04448@2157|Archaea,2XV15@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
DTH2_k127_1352458_4	521011.Mpal_0949	3.812e-64	222.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,2N9VD@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
DTH2_k127_1352458_1	368407.Memar_2045	2.562e-155	497.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,2N90F@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
DTH2_k127_1352458_10	593750.Metfor_0991	2.354e-13	69.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,2N9NX@224756|Methanomicrobia	224756|Methanomicrobia	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
DTH2_k127_1364930_1	324602.Caur_2347	3.923e-26	121.0	COG1515@1|root,COG1515@2|Bacteria,2G6SS@200795|Chloroflexi,375JK@32061|Chloroflexia	32061|Chloroflexia	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
DTH2_k127_1364930_0	593750.Metfor_0693	1.609e-177	562.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,2N985@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
DTH2_k127_1367120_2	593750.Metfor_1335	5.359e-105	347.0	COG0463@1|root,arCOG00894@2157|Archaea,2XTEG@28890|Euryarchaeota,2N988@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
DTH2_k127_1367120_3	368407.Memar_1663	5.701e-67	244.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
DTH2_k127_1367120_8	386456.JQKN01000002_gene2634	6.188e-09	65.0	arCOG08232@1|root,arCOG08232@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1367120_7	679926.Mpet_1690	8.773e-13	77.0	arCOG05300@1|root,arCOG05300@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
DTH2_k127_1367120_4	368407.Memar_1565	1.745e-45	168.0	COG1522@1|root,arCOG04153@2157|Archaea,2XX2W@28890|Euryarchaeota,2N9ZN@224756|Methanomicrobia	224756|Methanomicrobia	K	B-block binding subunit of TFIIIC	-	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC
DTH2_k127_1367120_6	456442.Mboo_1613	4.704e-31	123.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0FB@28890|Euryarchaeota,2NA05@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM
DTH2_k127_1367120_0	593750.Metfor_1105	1.063e-243	764.0	COG5310@1|root,arCOG05182@2157|Archaea	2157|Archaea	Q	Saccharopine dehydrogenase C-terminal domain	-	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2685	Sacchrp_dh_C,Sacchrp_dh_NADP
DTH2_k127_1367120_1	521011.Mpal_2447	7.199e-207	652.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
DTH2_k127_1367120_5	456442.Mboo_1612	1.972e-37	141.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota	28890|Euryarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
DTH2_k127_1374085_2	521011.Mpal_2022	4.465e-43	158.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2N98S@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
DTH2_k127_1374085_0	593750.Metfor_1665	3.016e-190	604.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,2NAEH@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
DTH2_k127_1374085_5	756067.MicvaDRAFT_2565	8.622e-13	74.0	COG0457@1|root,COG2909@1|root,COG0457@2|Bacteria,COG2909@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_6,TPR_8
DTH2_k127_1374085_1	368407.Memar_1614	1.593e-176	565.0	COG1103@1|root,arCOG00091@2157|Archaea,2XU3S@28890|Euryarchaeota,2NA7Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys))	-	-	2.5.1.73	ko:K06868	ko00970,map00970	-	R08577	RC02948	ko00000,ko00001,ko01000,ko03016	-	-	-	Aminotran_5,SepSecS
DTH2_k127_1374085_4	368407.Memar_1615	5.584e-13	70.0	arCOG07472@1|root,arCOG07472@2157|Archaea	2157|Archaea	-	-	-	-	2.5.1.73	ko:K06868	ko00970,map00970	-	R08577	RC02948	ko00000,ko00001,ko01000,ko03016	-	-	-	-
DTH2_k127_1374085_3	368407.Memar_1616	2.765e-22	97.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,2NA2J@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
DTH2_k127_1382968_1	368407.Memar_2234	2.235e-162	524.0	COG0438@1|root,arCOG01409@2157|Archaea,2Y8BI@28890|Euryarchaeota,2NB1P@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
DTH2_k127_1382968_0	456442.Mboo_1832	5.017e-208	656.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y2A7@28890|Euryarchaeota,2NA83@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DTH2_k127_1396738_0	368407.Memar_1784	1.047e-211	683.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
DTH2_k127_1396738_1	521011.Mpal_0113	8.679e-39	153.0	COG1321@1|root,arCOG02099@2157|Archaea	2157|Archaea	K	iron dependent repressor	sirR	-	-	ko:K03709,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
DTH2_k127_1396738_2	368407.Memar_1786	0.0009972	45.0	COG1796@1|root,arCOG00305@2157|Archaea,2XT14@28890|Euryarchaeota,2N90T@224756|Methanomicrobia	224756|Methanomicrobia	L	Helix-hairpin-helix domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8
DTH2_k127_1431245_2	706587.Desti_4859	2.463e-71	247.0	COG0463@1|root,COG0463@2|Bacteria,1QW1R@1224|Proteobacteria,42R1R@68525|delta/epsilon subdivisions,2WMTK@28221|Deltaproteobacteria,2MRP8@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
DTH2_k127_1431245_3	357808.RoseRS_1132	5.941e-17	86.0	COG2510@1|root,COG2510@2|Bacteria,2GBM1@200795|Chloroflexi,3781W@32061|Chloroflexia	32061|Chloroflexia	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DTH2_k127_1431245_0	926550.CLDAP_10910	8.723e-144	466.0	COG0399@1|root,COG0399@2|Bacteria,2G7Y0@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
DTH2_k127_1431245_4	1173028.ANKO01000250_gene2400	8.044e-16	83.0	2BWTW@1|root,315N7@2|Bacteria,1G5TV@1117|Cyanobacteria,1HB33@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1431245_1	760568.Desku_3528	1.708e-125	411.0	COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,24863@186801|Clostridia,263QH@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
DTH2_k127_1433466_0	269797.Mbar_A2518	5.403e-184	591.0	arCOG02806@1|root,arCOG02806@2157|Archaea,2XVAW@28890|Euryarchaeota,2NA80@224756|Methanomicrobia	224756|Methanomicrobia	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
DTH2_k127_1454555_0	368407.Memar_1815	1.835e-227	708.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
DTH2_k127_1454555_1	368407.Memar_1816	7.847e-117	383.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
DTH2_k127_1485554_0	368407.Memar_0050	4.994e-70	241.0	COG0655@1|root,arCOG02572@2157|Archaea,2Y8HN@28890|Euryarchaeota	368407.Memar_0050|-	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1485554_3	593750.Metfor_0133	1.64e-44	167.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,2NB15@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
DTH2_k127_1485554_1	456442.Mboo_0043	1.647e-68	238.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2N9QR@224756|Methanomicrobia	224756|Methanomicrobia	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH2_k127_1485554_2	368407.Memar_0053	1.446e-60	223.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,2N91J@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine biosynthesis protein ThiC	thiC-1	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
DTH2_k127_148647_1	368407.Memar_1418	6.422e-142	469.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
DTH2_k127_148647_0	368407.Memar_1419	1.507e-186	590.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
DTH2_k127_1489848_0	456442.Mboo_1781	5.137e-92	305.0	COG1625@1|root,arCOG00950@2157|Archaea,2XTIR@28890|Euryarchaeota,2N94K@224756|Methanomicrobia	224756|Methanomicrobia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH2_k127_1489848_2	1382306.JNIM01000001_gene3667	2.992e-18	93.0	COG0671@1|root,COG0671@2|Bacteria,2G7F8@200795|Chloroflexi	200795|Chloroflexi	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
DTH2_k127_1489848_1	593750.Metfor_0521	4.18e-30	121.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y1MD@28890|Euryarchaeota,2NA64@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1490903_2	368407.Memar_0839	8.355e-24	102.0	COG1624@1|root,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota,2N9M8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N
DTH2_k127_1490903_0	679926.Mpet_2269	1.061e-135	439.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
DTH2_k127_1490903_1	521011.Mpal_1946	1.82e-52	187.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
DTH2_k127_1515257_2	351160.LRC365	8.756e-30	119.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DTH2_k127_1515257_1	368407.Memar_0731	1.958e-34	137.0	arCOG05304@1|root,arCOG05304@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1515257_0	456442.Mboo_1475	1.689e-129	419.0	COG2221@1|root,arCOG02059@2157|Archaea	2157|Archaea	C	Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
DTH2_k127_1515257_3	368407.Memar_0733	3.726e-05	47.0	COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,2N9QS@224756|Methanomicrobia	224756|Methanomicrobia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
DTH2_k127_1517987_0	368407.Memar_0985	1.454e-244	762.0	COG0129@1|root,arCOG04045@2157|Archaea,2XSW2@28890|Euryarchaeota,2N992@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2069	ILVD_EDD
DTH2_k127_1517987_2	368407.Memar_0984	6.869e-92	314.0	COG0007@1|root,arCOG00644@2157|Archaea,2XTE1@28890|Euryarchaeota,2N96Z@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
DTH2_k127_1517987_1	593750.Metfor_1837	1.285e-100	339.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,2N97F@224756|Methanomicrobia	224756|Methanomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1465	Porphobil_deam,Porphobil_deamC
DTH2_k127_1517987_3	410358.Mlab_0525	2.463e-20	92.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,2N937@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH2_k127_1598444_1	368407.Memar_2353	2.082e-23	100.0	arCOG05294@1|root,arCOG05294@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
DTH2_k127_1598444_0	368407.Memar_2352	1.907e-106	359.0	COG1865@1|root,arCOG01870@2157|Archaea,2XUDZ@28890|Euryarchaeota,2N9UT@224756|Methanomicrobia	224756|Methanomicrobia	H	Cysteine-rich small domain	cbiZ	-	3.5.1.90	ko:K08260	ko00860,ko01100,map00860,map01100	-	R05226	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CbiZ,zf-like
DTH2_k127_1604286_0	368407.Memar_2057	1.085e-134	436.0	COG0367@1|root,arCOG00071@2157|Archaea,2XV5E@28890|Euryarchaeota,2N9BC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	asnB-1	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
DTH2_k127_1604286_2	706587.Desti_4300	1.596e-79	276.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
DTH2_k127_1604286_1	247490.KSU1_C0025	2.046e-105	361.0	COG2192@1|root,COG2192@2|Bacteria,2IYCS@203682|Planctomycetes	2|Bacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
DTH2_k127_1614243_3	521011.Mpal_1045	1.865e-09	59.0	COG1122@1|root,arCOG00202@2157|Archaea,2XT28@28890|Euryarchaeota,2NAFB@224756|Methanomicrobia	224756|Methanomicrobia	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
DTH2_k127_1614243_2	593750.Metfor_2237	1.782e-36	142.0	COG0310@1|root,arCOG03159@2157|Archaea,2Y22Y@28890|Euryarchaeota,2NBBK@224756|Methanomicrobia	224756|Methanomicrobia	P	PDGLE domain	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	PDGLE
DTH2_k127_1614243_1	593750.Metfor_2238	8.158e-99	327.0	COG0310@1|root,arCOG02248@2157|Archaea,2XU97@28890|Euryarchaeota,2NAT4@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
DTH2_k127_1614243_0	368407.Memar_1401	7.949e-134	436.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
DTH2_k127_1614243_4	368407.Memar_1400	8.533e-07	62.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,2N9U3@224756|Methanomicrobia	224756|Methanomicrobia	J	hydrolase	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
DTH2_k127_1614808_2	456442.Mboo_0235	8.011e-11	62.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1614808_0	335543.Sfum_0736	1.526e-119	401.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2MQRE@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH2_k127_1614808_1	521011.Mpal_1700	2.554e-22	108.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,2NAB8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
DTH2_k127_1632872_1	368407.Memar_2062	4.909e-71	242.0	COG4050@1|root,arCOG04903@2157|Archaea,2XY68@28890|Euryarchaeota,2N9PJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2112
DTH2_k127_1632872_0	593750.Metfor_0211	7.428e-217	677.0	COG1924@1|root,arCOG02679@2157|Archaea,2XU50@28890|Euryarchaeota,2N92J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
DTH2_k127_1632872_3	593750.Metfor_0210	3.494e-49	198.0	COG4051@1|root,arCOG04904@2157|Archaea,2Y0XT@28890|Euryarchaeota,2N9XA@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2113)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2113
DTH2_k127_1632872_2	323259.Mhun_2305	3.537e-65	227.0	COG4052@1|root,arCOG03226@2157|Archaea,2XTWG@28890|Euryarchaeota,2N9D6@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogenesis marker protein 7	-	-	-	-	-	-	-	-	-	-	-	-	MCR_C
DTH2_k127_1646154_1	368407.Memar_0220	8.612e-113	369.0	COG0247@1|root,COG0479@1|root,arCOG00333@2157|Archaea,arCOG00963@2157|Archaea,2Y85M@28890|Euryarchaeota,2N9EY@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
DTH2_k127_1646154_0	368407.Memar_0221	5.265e-137	442.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinate dehydrogenase fumarate reductase flavoprotein subunit	sdhA	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114	1.3.4.1,1.3.5.1,1.3.5.4	ko:K00239,ko:K18209	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376,M00620	R02164,R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
DTH2_k127_1704517_2	368407.Memar_2250	2.003e-85	288.0	arCOG05313@1|root,arCOG05313@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF1917)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1917
DTH2_k127_1704517_0	521011.Mpal_0594	1.049e-126	411.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,2N972@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
DTH2_k127_1704517_1	521011.Mpal_1453	8.109e-86	295.0	COG1940@1|root,arCOG04280@2157|Archaea,2XUQY@28890|Euryarchaeota	28890|Euryarchaeota	K	COG1940 Transcriptional regulator sugar kinase	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
DTH2_k127_1721423_3	593750.Metfor_0197	7.852e-58	203.0	COG1704@1|root,arCOG04574@2157|Archaea,2XX6E@28890|Euryarchaeota,2N9YK@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DTH2_k127_1721423_0	368407.Memar_2464	8.542e-171	555.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,2NA0A@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
DTH2_k127_1721423_2	269797.Mbar_A3428	4.541e-75	258.0	COG0785@1|root,arCOG02398@2157|Archaea,2XWA3@28890|Euryarchaeota,2N9AA@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
DTH2_k127_1721423_5	593750.Metfor_0075	5.97e-25	110.0	COG1605@1|root,arCOG02098@2157|Archaea,2Y6AQ@28890|Euryarchaeota,2N9YR@224756|Methanomicrobia	224756|Methanomicrobia	E	chorismate mutase	aroQ	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
DTH2_k127_1721423_4	521011.Mpal_1987	7.338e-57	212.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1721423_1	368407.Memar_0158	1.1e-80	275.0	COG0655@1|root,arCOG02572@2157|Archaea,2Y8HN@28890|Euryarchaeota	28890|Euryarchaeota	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DTH2_k127_1721423_6	368407.Memar_0159	5.295e-12	67.0	COG0655@1|root,arCOG02574@2157|Archaea	2157|Archaea	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DTH2_k127_1753245_0	368407.Memar_2160	1.865e-113	371.0	COG0253@1|root,arCOG02255@2157|Archaea,2XUYX@28890|Euryarchaeota,2NAG6@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
DTH2_k127_1753245_1	368407.Memar_2159	3.273e-78	269.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
DTH2_k127_1753245_2	593750.Metfor_0224	7.957e-18	85.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,2N9FA@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
DTH2_k127_1849764_2	368407.Memar_0489	1.983e-50	186.0	arCOG02780@1|root,arCOG02780@2157|Archaea,2XZQI@28890|Euryarchaeota,2N9W5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_1849764_0	521011.Mpal_1203	4.855e-97	325.0	COG1693@1|root,arCOG02711@2157|Archaea,2XUUJ@28890|Euryarchaeota,2N94A@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function DUF128	-	-	-	ko:K21640	-	-	-	-	ko00000	-	-	-	DUF128
DTH2_k127_1849764_1	521011.Mpal_1202	1.032e-61	220.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,2N9ZM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DTH2_k127_1852001_2	593750.Metfor_1699	4.415e-90	299.0	COG0559@1|root,arCOG01270@2157|Archaea,2XUY9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0559 Branched-chain amino acid ABC-type transport system, permease components	livH5	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH2_k127_1852001_0	593750.Metfor_1700	6.325e-129	419.0	COG4177@1|root,arCOG01274@2157|Archaea,2XVR5@28890|Euryarchaeota	28890|Euryarchaeota	E	Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH2_k127_1852001_1	593750.Metfor_1701	2.145e-103	342.0	COG0410@1|root,arCOG00924@2157|Archaea,2XT1R@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type branched-chain amino acid transport systems ATPase component	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DTH2_k127_1852001_3	593750.Metfor_1702	1.751e-76	260.0	COG0411@1|root,arCOG00926@2157|Archaea,2XU0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DTH2_k127_1895856_5	593750.Metfor_0998	1.439e-19	93.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,2N9Z3@224756|Methanomicrobia	224756|Methanomicrobia	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
DTH2_k127_1895856_3	323259.Mhun_1130	3.403e-49	176.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,2N9XH@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
DTH2_k127_1895856_4	521011.Mpal_0956	7.634e-25	107.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
DTH2_k127_1895856_0	368407.Memar_2051	4.632e-106	351.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,2N93I@224756|Methanomicrobia	224756|Methanomicrobia	J	Translation initiation factor 2 alpha subunit	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
DTH2_k127_1895856_6	593750.Metfor_1002	2.072e-13	74.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,2NA3J@224756|Methanomicrobia	224756|Methanomicrobia	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
DTH2_k127_1895856_1	593750.Metfor_1003	2.084e-93	312.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2N9I4@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
DTH2_k127_1895856_2	410358.Mlab_1296	1.414e-78	266.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,2N99G@224756|Methanomicrobia	224756|Methanomicrobia	S	PHP C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
DTH2_k127_189741_4	368407.Memar_1400	5.159e-46	169.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,2N9U3@224756|Methanomicrobia	224756|Methanomicrobia	J	hydrolase	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
DTH2_k127_189741_5	1121957.ATVL01000013_gene61	2.136e-24	119.0	COG3291@1|root,COG3291@2|Bacteria,4PKMZ@976|Bacteroidetes,47XXW@768503|Cytophagia	976|Bacteroidetes	T	TIGRFAM Por secretion system C-terminal sorting domain	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C
DTH2_k127_189741_0	368407.Memar_1399	2.219e-145	474.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
DTH2_k127_189741_2	456442.Mboo_0907	5.866e-80	276.0	COG0616@1|root,arCOG01311@2157|Archaea,2XTG8@28890|Euryarchaeota,2N9DH@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM signal peptide peptidase SppA, 36K type	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
DTH2_k127_189741_1	456442.Mboo_0908	8.348e-115	386.0	COG1985@1|root,arCOG01484@2157|Archaea,2Y3FX@28890|Euryarchaeota,2NARM@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM bifunctional deaminase-reductase domain protein	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
DTH2_k127_189741_3	593750.Metfor_2281	9.02e-75	271.0	COG0558@1|root,arCOG00670@2157|Archaea,2XZF4@28890|Euryarchaeota,2NAX5@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
DTH2_k127_1925170_3	368407.Memar_1690	2.916e-37	141.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2N9RS@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
DTH2_k127_1925170_1	521011.Mpal_2538	8.913e-60	223.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2N9RM@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM cytidyltransferase-related domain	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DTH2_k127_1925170_2	521011.Mpal_2539	1.024e-59	210.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2N9S0@224756|Methanomicrobia	224756|Methanomicrobia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
DTH2_k127_1925170_0	368407.Memar_1693	3.504e-100	331.0	COG1148@1|root,arCOG02234@2157|Archaea,2Y7JF@28890|Euryarchaeota,2NBK7@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,Pyr_redox_2
DTH2_k127_1943910_0	368407.Memar_1551	6.859e-162	518.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,2N92F@224756|Methanomicrobia	224756|Methanomicrobia	L	acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DnaJ_CXXCXGXG,S1,tRNA_anti-codon
DTH2_k127_1943910_1	368407.Memar_1554	5.393e-140	453.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
DTH2_k127_1943910_2	368407.Memar_1555	9.43e-87	290.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2N9NR@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DTH2_k127_19513_1	593750.Metfor_0176	2.272e-52	186.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N95M@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	iAF692.Mbar_A3463	Aminotran_1_2
DTH2_k127_19513_0	456442.Mboo_0796	3.073e-144	466.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,2N9AE@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
DTH2_k127_19513_2	368407.Memar_1626	2.882e-22	99.0	COG0863@1|root,arCOG00115@2157|Archaea,2XWB2@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DTH2_k127_1959041_0	456442.Mboo_1108	2.121e-238	745.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,2N9IK@224756|Methanomicrobia	224756|Methanomicrobia	L	SMART DNA-directed DNA polymerase B	polB-1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
DTH2_k127_196449_0	368407.Memar_1041	1.323e-196	624.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2NAI4@224756|Methanomicrobia	224756|Methanomicrobia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,PAPS_reduct
DTH2_k127_2113992_0	768679.TTX_1787	5.366e-66	234.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRM8@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
DTH2_k127_2113992_2	1192868.CAIU01000019_gene2706	1.149e-40	156.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,2UCUJ@28211|Alphaproteobacteria,43KP6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
DTH2_k127_2113992_1	498761.HM1_2718	1.739e-61	226.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,25E7A@186801|Clostridia	186801|Clostridia	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
DTH2_k127_2151352_0	118005.AWNK01000007_gene599	9.162e-138	443.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
DTH2_k127_2151352_1	1244869.H261_15537	1.101e-101	344.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TWTV@28211|Alphaproteobacteria,2JZ5K@204441|Rhodospirillales	204441|Rhodospirillales	G	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH2_k127_2156868_2	368407.Memar_0634	1.113e-83	282.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N92R@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC-2	-	4.2.1.114	ko:K16792	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
DTH2_k127_2156868_4	368407.Memar_0635	3.75e-67	236.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2N9JK@224756|Methanomicrobia	224756|Methanomicrobia	E	Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B	hacB	-	4.2.1.114	ko:K16793	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2270	Aconitase_C
DTH2_k127_2156868_1	593750.Metfor_2590	8.092e-98	334.0	arCOG04973@1|root,arCOG04973@2157|Archaea,2XX73@28890|Euryarchaeota,2N9K2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2156868_0	593750.Metfor_2589	4.357e-132	428.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N94T@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	aksF	-	1.1.1.87	ko:K10978	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R01934,R01936,R04862,R08214,R08215	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH2_k127_2156868_5	909663.KI867149_gene3176	4.482e-39	152.0	COG1913@1|root,COG1913@2|Bacteria,1N38I@1224|Proteobacteria,42UMZ@68525|delta/epsilon subdivisions,2WRS9@28221|Deltaproteobacteria,2MS0H@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
DTH2_k127_2156868_3	456442.Mboo_1644	8.855e-76	258.0	COG0500@1|root,arCOG01401@2157|Archaea	2157|Archaea	Q	TIGRFAM methyltransferase FkbM family	-	-	-	-	-	-	-	-	-	-	-	-	Met_10,Methyltransf_21
DTH2_k127_2205942_1	304371.MCP_2288	2.273e-66	232.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DTH2_k127_2205942_2	304371.MCP_2287	1.969e-33	136.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y46J@28890|Euryarchaeota,2NB12@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE-2	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
DTH2_k127_2205942_3	593750.Metfor_0254	1.167e-21	95.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y4F6@28890|Euryarchaeota,2NB8I@224756|Methanomicrobia	224756|Methanomicrobia	C	ATP synthase subunit C	atpK-2	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
DTH2_k127_2205942_0	593750.Metfor_0263	3.426e-222	706.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2NAKS@224756|Methanomicrobia	224756|Methanomicrobia	C	V-type ATPase 116kDa subunit family	atpI-2	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DTH2_k127_2205942_4	304371.MCP_2294	9.945e-06	52.0	COG2811@1|root,arCOG03363@2157|Archaea	2157|Archaea	C	H subunit	ahaH	-	-	ko:K02107	ko00190,map00190	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V-ATPase_G_2
DTH2_k127_2266975_1	456442.Mboo_1924	5.77e-84	286.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
DTH2_k127_2266975_0	368407.Memar_2007	6.986e-226	710.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2N924@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM PilT protein domain protein	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
DTH2_k127_2473800_2	456442.Mboo_2054	7.624e-21	93.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2NAI4@224756|Methanomicrobia	224756|Methanomicrobia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,PAPS_reduct
DTH2_k127_2473800_0	456442.Mboo_2119	1.715e-137	443.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,2N922@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
DTH2_k127_2473800_1	456442.Mboo_2042	3.914e-128	417.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
DTH2_k127_2533809_4	521011.Mpal_1335	1.071e-63	248.0	COG0784@1|root,arCOG02336@1|root,arCOG02338@1|root,arCOG06712@1|root,arCOG02333@2157|Archaea,arCOG02336@2157|Archaea,arCOG02338@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
DTH2_k127_2533809_6	323259.Mhun_1124	1.95e-18	86.0	COG1145@1|root,arCOG00958@2157|Archaea,2Y1CC@28890|Euryarchaeota,2NA30@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DTH2_k127_2533809_0	456442.Mboo_1945	5.593e-178	565.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,2N99C@224756|Methanomicrobia	224756|Methanomicrobia	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	bchP	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3
DTH2_k127_2533809_5	456442.Mboo_1943	1.835e-63	224.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,2N9PE@224756|Methanomicrobia	224756|Methanomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
DTH2_k127_2533809_1	593750.Metfor_1014	2.846e-115	386.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,2N9D0@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
DTH2_k127_2533809_8	706587.Desti_4027	6.146e-09	66.0	COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MRYH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
DTH2_k127_2533809_3	456442.Mboo_1940	4.052e-83	284.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,2N97C@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
DTH2_k127_2533809_2	456442.Mboo_1911	5.665e-105	346.0	COG0455@1|root,arCOG00589@2157|Archaea,2XT20@28890|Euryarchaeota,2N9KH@224756|Methanomicrobia	224756|Methanomicrobia	D	TIGRFAM cell division ATPase MinD	-	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	CbiA
DTH2_k127_2533809_7	593750.Metfor_1066	7.904e-14	79.0	arCOG03412@1|root,arCOG03412@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
DTH2_k127_2580354_0	456442.Mboo_0555	1.597e-122	398.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,2N9AJ@224756|Methanomicrobia	224756|Methanomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
DTH2_k127_2580354_3	593750.Metfor_2633	4.076e-41	155.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2N9U7@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
DTH2_k127_2580354_2	593750.Metfor_2634	2.401e-75	254.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2N9JA@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM ribosomal protein L30P	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
DTH2_k127_2580354_1	521011.Mpal_0462	9.442e-103	336.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,2N954@224756|Methanomicrobia	224756|Methanomicrobia	J	With S4 and S12 plays an important role in translational accuracy	rps5	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
DTH2_k127_2580354_4	521011.Mpal_0461	3.022e-31	124.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2N9SW@224756|Methanomicrobia	224756|Methanomicrobia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
DTH2_k127_2600250_0	243231.GSU2309	1.917e-175	561.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	domain, Protein	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
DTH2_k127_2600250_1	593750.Metfor_2420	1.788e-72	248.0	COG2391@1|root,arCOG04787@2157|Archaea,2Y1J9@28890|Euryarchaeota,2NBC4@224756|Methanomicrobia	224756|Methanomicrobia	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
DTH2_k127_2600250_2	593750.Metfor_2421	5.424e-18	84.0	COG2391@1|root,arCOG04788@2157|Archaea,2Y7I6@28890|Euryarchaeota,2NB94@224756|Methanomicrobia	224756|Methanomicrobia	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
DTH2_k127_2619037_0	593750.Metfor_0778	3.868e-127	409.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N97Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
DTH2_k127_2619037_1	368407.Memar_1948	1.717e-63	234.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2N9GR@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
DTH2_k127_2619037_2	368407.Memar_1947	2.708e-29	120.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N918@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH2_k127_2639575_5	679926.Mpet_1634	5.166e-25	108.0	COG1153@1|root,arCOG02674@2157|Archaea	2157|Archaea	C	PFAM molydopterin dinucleotide-binding region	fwdD	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114	1.2.7.12	ko:K00201,ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
DTH2_k127_2639575_1	368407.Memar_1187	1.846e-203	640.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
DTH2_k127_2639575_0	368407.Memar_1188	3.935e-305	942.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,2N9G0@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
DTH2_k127_2639575_3	679926.Mpet_2421	6.868e-97	329.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2NAVQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
DTH2_k127_2639575_4	368407.Memar_0795	8.029e-96	321.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,2N98G@224756|Methanomicrobia	224756|Methanomicrobia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
DTH2_k127_2639575_2	368407.Memar_0796	7.304e-116	376.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DTH2_k127_2644968_1	521011.Mpal_0935	7.547e-87	291.0	COG0249@1|root,arCOG02897@2157|Archaea,2XT0M@28890|Euryarchaeota,2N9EU@224756|Methanomicrobia	224756|Methanomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
DTH2_k127_2644968_0	456442.Mboo_1217	8.729e-174	564.0	COG0323@1|root,arCOG01166@2157|Archaea,2XTK1@28890|Euryarchaeota,2N9DA@224756|Methanomicrobia	224756|Methanomicrobia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
DTH2_k127_2657512_0	368407.Memar_0314	1.013e-295	914.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,2N96G@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DTH2_k127_2657512_1	456442.Mboo_1931	2.004e-134	439.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,2N927@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
DTH2_k127_2657745_0	368407.Memar_0406	3.137e-107	357.0	COG0303@1|root,arCOG00216@2157|Archaea,2Y7MS@28890|Euryarchaeota,2NBMK@224756|Methanomicrobia	224756|Methanomicrobia	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
DTH2_k127_2657745_2	368407.Memar_0407	6.613e-18	84.0	arCOG09439@1|root,arCOG09439@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2657745_1	368407.Memar_0408	2.144e-39	151.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,2N9S6@224756|Methanomicrobia	224756|Methanomicrobia	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
DTH2_k127_2664297_0	456442.Mboo_2390	7.7e-155	497.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DTH2_k127_2664297_1	593750.Metfor_0294	4.101e-68	234.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
DTH2_k127_2670103_1	368407.Memar_1314	4.653e-30	122.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,2N962@224756|Methanomicrobia	224756|Methanomicrobia	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
DTH2_k127_2670103_0	224325.AF_0220	9.124e-164	527.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,245X6@183980|Archaeoglobi	183980|Archaeoglobi	I	acetyl-CoA carboxylase, biotin carboxylase	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DTH2_k127_2673274_2	521011.Mpal_0150	1.571e-30	123.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,2N9Y7@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
DTH2_k127_2673274_1	456442.Mboo_2270	3.31e-90	305.0	COG4021@1|root,arCOG03218@2157|Archaea,2XWU9@28890|Euryarchaeota,2N9I7@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNAHis guanylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thg1,Thg1C
DTH2_k127_2673274_0	368407.Memar_0403	0.0	1427.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
DTH2_k127_2679294_1	1151122.AQYD01000007_gene376	0.0004828	44.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4FMR0@85023|Microbacteriaceae	201174|Actinobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,MFS_3,Thymidylate_kin
DTH2_k127_2679294_0	368407.Memar_1572	0.0	1254.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
DTH2_k127_2694403_2	593750.Metfor_2403	1.833e-77	264.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
DTH2_k127_2694403_1	521011.Mpal_1075	4.651e-90	314.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
DTH2_k127_2694403_0	456442.Mboo_0736	1.439e-114	374.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,2N99H@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
DTH2_k127_2694403_3	521011.Mpal_1077	4.632e-54	193.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV0M@28890|Euryarchaeota	28890|Euryarchaeota	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
DTH2_k127_2699875_1	593750.Metfor_0652	1.982e-43	162.0	COG1633@1|root,arCOG01102@2157|Archaea,2Y446@28890|Euryarchaeota,2NB0Q@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_2699875_0	368407.Memar_1431	9.527e-48	177.0	COG0622@1|root,arCOG01141@2157|Archaea,2XX8V@28890|Euryarchaeota,2NB0G@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
DTH2_k127_2699875_2	593750.Metfor_2530	7.463e-14	81.0	arCOG09579@1|root,arCOG09579@2157|Archaea,2Y58J@28890|Euryarchaeota,2NBAR@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2702018_2	679926.Mpet_0982	7.28e-12	66.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,2N9YQ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
DTH2_k127_2702018_0	368407.Memar_1238	3.332e-100	337.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
DTH2_k127_2702018_1	368407.Memar_1237	5.415e-100	333.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
DTH2_k127_2741571_1	521011.Mpal_0314	4.796e-159	510.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
DTH2_k127_2741571_2	368407.Memar_2230	5.779e-145	468.0	COG1208@1|root,arCOG00668@2157|Archaea,2Y87G@28890|Euryarchaeota,2N9FU@224756|Methanomicrobia	224756|Methanomicrobia	M	transferase hexapeptide repeat containing protein	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DTH2_k127_2741571_0	368407.Memar_2231	8.077e-248	780.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,2N92X@224756|Methanomicrobia	224756|Methanomicrobia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DTH2_k127_2741571_3	368407.Memar_2232	9.76e-73	273.0	COG0110@1|root,arCOG01848@2157|Archaea,2XWJM@28890|Euryarchaeota,2N98J@224756|Methanomicrobia	224756|Methanomicrobia	S	transferase hexapeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
DTH2_k127_2741571_4	323259.Mhun_2142	3.529e-31	134.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,2N9FX@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
DTH2_k127_2743049_0	456442.Mboo_1906	3.221e-287	904.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DTH2_k127_2743049_1	368407.Memar_2002	1.76e-12	69.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y7HY@28890|Euryarchaeota,2NBK4@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DTH2_k127_2747947_2	679926.Mpet_1213	1.809e-89	298.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2N994@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH2_k127_2747947_1	521011.Mpal_0778	1.607e-98	325.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DTH2_k127_2747947_0	521011.Mpal_0777	8.846e-269	832.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,2N99U@224756|Methanomicrobia	224756|Methanomicrobia	S	KH, type 1, domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
DTH2_k127_2753656_3	679926.Mpet_2592	3.587e-27	115.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,2N92N@224756|Methanomicrobia	224756|Methanomicrobia	D	PFAM PP-loop domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
DTH2_k127_2753656_1	368407.Memar_0482	9.758e-118	384.0	COG0478@1|root,arCOG01181@2157|Archaea,2XUJ4@28890|Euryarchaeota,2N9I8@224756|Methanomicrobia	224756|Methanomicrobia	T	Rio2, N-terminal	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
DTH2_k127_2753656_0	368407.Memar_0481	1.489e-223	714.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
DTH2_k127_2753656_2	368407.Memar_0480	4.532e-96	321.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,2N9G5@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DTH2_k127_2766638_3	1502852.FG94_01090	2.203e-38	167.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VIZX@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
DTH2_k127_2766638_1	456442.Mboo_1487	1.689e-155	527.0	COG0642@1|root,arCOG02352@1|root,arCOG02352@2157|Archaea,arCOG06192@2157|Archaea	2157|Archaea	T	TIGRFAM PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_2,PAS,PAS_4,PAS_8,PAS_9,Response_reg
DTH2_k127_2766638_0	593750.Metfor_2800	1.05e-184	586.0	COG0784@1|root,COG1695@1|root,arCOG00001@2157|Archaea,arCOG06537@2157|Archaea,2XWYJ@28890|Euryarchaeota,2NB86@224756|Methanomicrobia	224756|Methanomicrobia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DTH2_k127_2766638_5	1455608.JDTH01000002_gene1861	1.252e-07	58.0	COG0071@1|root,arCOG01833@2157|Archaea,2XY1D@28890|Euryarchaeota,23WAJ@183963|Halobacteria	183963|Halobacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp20b	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DTH2_k127_2766638_2	593750.Metfor_2040	1.505e-65	246.0	COG0642@1|root,arCOG02348@1|root,arCOG03931@1|root,arCOG02348@2157|Archaea,arCOG03931@2157|Archaea,arCOG06193@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
DTH2_k127_2797387_1	521011.Mpal_0301	8.346e-57	204.0	COG1592@1|root,arCOG01097@2157|Archaea,2XXBF@28890|Euryarchaeota,2N9UW@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_2797387_0	593750.Metfor_0067	1.979e-75	258.0	COG0655@1|root,arCOG02574@2157|Archaea	2157|Archaea	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DTH2_k127_2813679_1	456442.Mboo_0707	5.952e-188	599.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia	224756|Methanomicrobia	G	Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
DTH2_k127_2813679_2	456442.Mboo_0708	1.813e-57	203.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota,2N9SE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DTH2_k127_2813679_0	593750.Metfor_2501	1.673e-219	692.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N95A@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
DTH2_k127_2813679_3	368407.Memar_0750	2.475e-41	153.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N9EC@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
DTH2_k127_2829533_2	593750.Metfor_0020	2.638e-98	325.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,2N9HB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1524	DHBP_synthase
DTH2_k127_2829533_3	593750.Metfor_0021	6.033e-82	279.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,2N9NG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,MarR
DTH2_k127_2829533_4	351160.RCIX148	4.352e-73	253.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,2N9HI@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DTH2_k127_2829533_0	368407.Memar_2361	1.78e-189	595.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,2N99Q@224756|Methanomicrobia	224756|Methanomicrobia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
DTH2_k127_2829533_1	456442.Mboo_0156	9.653e-135	454.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
DTH2_k127_2840020_0	368407.Memar_0643	1.654e-212	668.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,2N94C@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
DTH2_k127_2840020_1	593750.Metfor_2551	4.274e-33	129.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
DTH2_k127_2852752_1	456442.Mboo_0767	1.505e-54	195.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,2NA1R@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
DTH2_k127_2852752_0	368407.Memar_1087	5.919e-169	547.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,2N91D@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent	dadD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
DTH2_k127_2864420_3	521011.Mpal_1548	2.843e-43	160.0	COG2038@1|root,arCOG04272@2157|Archaea,2XTPU@28890|Euryarchaeota,2N9K1@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_2864420_0	368407.Memar_0736	9.118e-81	273.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,2N9KA@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
DTH2_k127_2864420_2	368407.Memar_0737	1.14e-52	191.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DTH2_k127_2864420_1	679926.Mpet_0680	2.373e-67	234.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYGC@28890|Euryarchaeota,2NAUV@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DTH2_k127_2864420_4	368407.Memar_0740	2.828e-36	141.0	COG4066@1|root,arCOG03215@2157|Archaea,2Y0A8@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0305 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2115
DTH2_k127_3054526_0	456442.Mboo_1784	1.078e-247	773.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,2N90X@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM oxaloacetate decarboxylase alpha subunit	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1586	Biotin_lipoyl,HMGL-like,PYC_OADA
DTH2_k127_3054526_1	368407.Memar_1642	2.67e-31	126.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DTH2_k127_3056961_5	368407.Memar_2408	4.438e-22	101.0	COG1575@1|root,arCOG00480@2157|Archaea,2XXM6@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
DTH2_k127_3056961_3	593750.Metfor_2034	1.279e-51	187.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,2NA23@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
DTH2_k127_3056961_1	456442.Mboo_1272	3.951e-237	741.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
DTH2_k127_3056961_2	456442.Mboo_1271	2.25e-84	290.0	COG0327@1|root,arCOG04454@2157|Archaea,2XT5G@28890|Euryarchaeota,2N9RT@224756|Methanomicrobia	224756|Methanomicrobia	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
DTH2_k127_3056961_4	521011.Mpal_1288	6.155e-28	119.0	COG5431@1|root,arCOG01121@2157|Archaea,2XY1I@28890|Euryarchaeota	28890|Euryarchaeota	S	zinc finger, SWIM	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
DTH2_k127_3056961_0	521011.Mpal_1287	1.231e-272	849.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DTH2_k127_3102218_0	368407.Memar_0633	5.122e-129	419.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,2N9F5@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
DTH2_k127_3102218_1	323259.Mhun_1802	1.967e-39	157.0	COG4231@1|root,arCOG01612@2157|Archaea,2XWAR@28890|Euryarchaeota,2N95R@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C,TPP_enzyme_N
DTH2_k127_3142175_3	456442.Mboo_1441	1.38e-15	78.0	COG4066@1|root,arCOG03215@2157|Archaea	2157|Archaea	L	Belongs to the UPF0305 family	-	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF2115
DTH2_k127_3142175_2	679926.Mpet_2051	7.793e-24	105.0	COG4828@1|root,arCOG03300@2157|Archaea,2Y0K6@28890|Euryarchaeota,2NA5G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
DTH2_k127_3142175_0	593750.Metfor_0761	8.66e-110	366.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,2N9NQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
DTH2_k127_3142175_1	593750.Metfor_0760	9.651e-56	202.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
DTH2_k127_3169437_0	593750.Metfor_1447	2.929e-115	377.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,2N94F@224756|Methanomicrobia	224756|Methanomicrobia	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
DTH2_k127_3171982_1	368407.Memar_0759	2.071e-59	211.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,2N940@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
DTH2_k127_3171982_2	1123288.SOV_2c02070	2.929e-45	171.0	COG4832@1|root,COG4832@2|Bacteria,1TQC2@1239|Firmicutes,4H5FS@909932|Negativicutes	909932|Negativicutes	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
DTH2_k127_3171982_0	593750.Metfor_2304	1.385e-93	314.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,2NAVM@224756|Methanomicrobia	224756|Methanomicrobia	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
DTH2_k127_329703_2	368407.Memar_1465	3.948e-33	128.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,2N9FQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
DTH2_k127_329703_1	368407.Memar_1466	3.298e-52	192.0	arCOG05301@1|root,arCOG05301@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_329703_0	368407.Memar_1469	1.084e-64	229.0	arCOG00567@1|root,arCOG00567@2157|Archaea,2XVU1@28890|Euryarchaeota,2NA3X@224756|Methanomicrobia	224756|Methanomicrobia	M	glycosyl transferase, family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DTH2_k127_3340584_0	323259.Mhun_2932	2.741e-136	444.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NA6W@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DTH2_k127_3340584_1	368407.Memar_0493	2.139e-91	312.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2N9I9@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH2_k127_3340584_2	368407.Memar_0063	1.632e-85	306.0	COG1361@1|root,arCOG04400@2157|Archaea,2XZN3@28890|Euryarchaeota,2N9X5@224756|Methanomicrobia	224756|Methanomicrobia	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
DTH2_k127_3340584_3	521011.Mpal_1255	2.56e-40	157.0	COG2881@1|root,arCOG02054@2157|Archaea,2XTJC@28890|Euryarchaeota,2NA62@224756|Methanomicrobia	224756|Methanomicrobia	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
DTH2_k127_3340584_4	521011.Mpal_2571	1.745e-31	130.0	COG0394@1|root,arCOG04425@2157|Archaea,2XZ4R@28890|Euryarchaeota,2N9TH@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DTH2_k127_3340584_5	679926.Mpet_2150	8.896e-15	83.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
DTH2_k127_3347071_0	593750.Metfor_0701	2.725e-211	664.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,2N94B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
DTH2_k127_3347071_1	679926.Mpet_2387	1.71e-38	154.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,2N92B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
DTH2_k127_3356890_0	368407.Memar_0789	1.767e-153	494.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,2N91F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DEAD_2 domain protein	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
DTH2_k127_3356890_1	521011.Mpal_1701	1.165e-109	379.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,2N963@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
DTH2_k127_3367979_4	368407.Memar_2170	3.473e-11	63.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,2N9JI@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
DTH2_k127_3367979_3	593750.Metfor_2708	8.19e-31	123.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
DTH2_k127_3367979_1	521011.Mpal_2582	1.523e-89	307.0	COG1235@1|root,arCOG00499@2157|Archaea,2XTWY@28890|Euryarchaeota,2N9GT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM beta-lactamase domain protein	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
DTH2_k127_3367979_0	456442.Mboo_0486	1.035e-162	522.0	COG0464@1|root,arCOG04368@2157|Archaea,2XT63@28890|Euryarchaeota,2N9B2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
DTH2_k127_3367979_2	368407.Memar_2090	2.996e-60	211.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DTH2_k127_3494757_2	456442.Mboo_1781	7.653e-96	318.0	COG1625@1|root,arCOG00950@2157|Archaea,2XTIR@28890|Euryarchaeota,2N94K@224756|Methanomicrobia	224756|Methanomicrobia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH2_k127_3494757_1	593750.Metfor_0715	1.332e-154	500.0	COG0475@1|root,arCOG01953@2157|Archaea,2XV77@28890|Euryarchaeota,2NATR@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
DTH2_k127_3494757_0	269797.Mbar_A2053	4.526e-176	563.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,2N96P@224756|Methanomicrobia	224756|Methanomicrobia	E	Domain of unknown function (DUF3458_C) ARM repeats	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
DTH2_k127_3506082_1	593750.Metfor_1189	6.164e-24	104.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,2N9X8@224756|Methanomicrobia	224756|Methanomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
DTH2_k127_3506082_2	593750.Metfor_1188	4.727e-22	98.0	COG0695@1|root,arCOG02607@2157|Archaea	2157|Archaea	O	COG3634 Alkyl hydroperoxide reductase, large subunit	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
DTH2_k127_3506082_0	368407.Memar_0320	0.0	1241.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
DTH2_k127_353360_0	368407.Memar_1247	3.501e-114	374.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,2N9E6@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
DTH2_k127_353360_1	593750.Metfor_1352	1.764e-105	346.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2N91S@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rad17,Rep_fac_C
DTH2_k127_3555851_0	368407.Memar_2319	1.245e-178	573.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,2NA7I@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA-2	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
DTH2_k127_3555851_1	368407.Memar_2318	1.83e-122	398.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2NA8Q@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM thiamine pyrophosphate enzyme	porB-2	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
DTH2_k127_3653892_2	1041930.Mtc_1380	1.992e-14	75.0	COG2006@1|root,arCOG02447@2157|Archaea,2XW1U@28890|Euryarchaeota,2N9D9@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_7
DTH2_k127_3653892_1	1207063.P24_03680	2.377e-21	97.0	COG4095@1|root,COG4095@2|Bacteria,1N759@1224|Proteobacteria,2UG31@28211|Alphaproteobacteria,2JTWT@204441|Rhodospirillales	204441|Rhodospirillales	S	Sugar efflux transporter for intercellular exchange	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	PQ-loop
DTH2_k127_3653892_0	368407.Memar_1536	3.549e-96	326.0	COG4022@1|root,arCOG04893@2157|Archaea,2XVN1@28890|Euryarchaeota,2N9I3@224756|Methanomicrobia	224756|Methanomicrobia	S	Methanogenesis marker protein 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF2099
DTH2_k127_3653892_3	479434.Sthe_3142	8.133e-05	54.0	COG3503@1|root,COG3503@2|Bacteria,2G90I@200795|Chloroflexi,27Z6J@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
DTH2_k127_3740271_3	456442.Mboo_0551	2.082e-45	167.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2N9SW@224756|Methanomicrobia	224756|Methanomicrobia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
DTH2_k127_3740271_1	593750.Metfor_2637	3.045e-61	215.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,2N9QQ@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
DTH2_k127_3740271_4	323259.Mhun_2236	1.789e-31	134.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,2N9TN@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
DTH2_k127_3740271_0	456442.Mboo_0548	2.814e-64	229.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,2N9KP@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
DTH2_k127_3740271_2	593750.Metfor_2640	1.008e-49	178.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2N9Q6@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
DTH2_k127_379864_1	304371.MCP_0111	7.515e-20	91.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,2N9YJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
DTH2_k127_379864_0	593750.Metfor_2124	1.917e-166	532.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,2N98U@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
DTH2_k127_3808631_2	368407.Memar_0365	1.983e-41	156.0	COG0537@1|root,arCOG00419@2157|Archaea,2Y0J5@28890|Euryarchaeota,2NA21@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM histidine triad (HIT) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
DTH2_k127_3808631_0	368407.Memar_1421	1.364e-92	320.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,2N9ME@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
DTH2_k127_3808631_1	368407.Memar_1420	4.549e-92	306.0	arCOG04725@1|root,arCOG04725@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GerE
DTH2_k127_3812131_4	593750.Metfor_0461	5.31e-11	63.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,2N9KM@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
DTH2_k127_3812131_0	521011.Mpal_2658	1.371e-228	719.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
DTH2_k127_3812131_5	269797.Mbar_A2112	1.349e-05	52.0	arCOG01354@1|root,arCOG01354@2157|Archaea	2157|Archaea	-	-	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Pcc1
DTH2_k127_3812131_1	368407.Memar_0429	1.035e-107	364.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
DTH2_k127_3812131_3	368407.Memar_0430	9.03e-64	221.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,2N9S2@224756|Methanomicrobia	224756|Methanomicrobia	J	ribosomal protein S15	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
DTH2_k127_3812131_2	368407.Memar_2020	1.219e-77	278.0	COG0642@1|root,arCOG02346@1|root,arCOG06516@1|root,arCOG02346@2157|Archaea,arCOG06192@2157|Archaea,arCOG06516@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DTH2_k127_3814466_0	593750.Metfor_2783	5.396e-68	234.0	arCOG11509@1|root,arCOG11509@2157|Archaea,2Y3KG@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3814466_2	593750.Metfor_0411	1.028e-13	83.0	arCOG11437@1|root,arCOG11437@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3814466_1	456442.Mboo_1854	1.827e-29	133.0	COG2319@1|root,arCOG02491@2157|Archaea	2157|Archaea	L	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
DTH2_k127_3824464_0	368407.Memar_2038	5.481e-145	467.0	COG0388@1|root,arCOG00062@2157|Archaea,2XVVK@28890|Euryarchaeota,2NBG5@224756|Methanomicrobia	224756|Methanomicrobia	S	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase,PAD_porph
DTH2_k127_3824464_3	368407.Memar_1633	1.554e-51	195.0	COG0518@1|root,arCOG00090@2157|Archaea,2Y5MH@28890|Euryarchaeota	28890|Euryarchaeota	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
DTH2_k127_3824464_1	368407.Memar_1634	6.766e-85	288.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
DTH2_k127_3824464_2	1379281.AVAG01000011_gene1275	1.121e-61	225.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42P92@68525|delta/epsilon subdivisions,2WKXT@28221|Deltaproteobacteria,2MA2T@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DTH2_k127_3826286_2	593750.Metfor_0973	2.973e-21	100.0	arCOG09605@1|root,arCOG09605@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3826286_0	593750.Metfor_1603	1.531e-61	218.0	COG0169@1|root,arCOG02097@2157|Archaea,2XWH4@28890|Euryarchaeota,2N9XM@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
DTH2_k127_3826286_1	368407.Memar_1293	1.208e-39	153.0	COG0826@1|root,arCOG03203@2157|Archaea,2XT7F@28890|Euryarchaeota,2N97J@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DTH2_k127_3844795_0	368407.Memar_1298	1.384e-133	448.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,2N97U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
DTH2_k127_3844795_1	368407.Memar_1299	3.351e-88	296.0	COG0077@1|root,arCOG00255@2157|Archaea,2XTAI@28890|Euryarchaeota,2N9DQ@224756|Methanomicrobia	224756|Methanomicrobia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
DTH2_k127_3867694_0	593750.Metfor_2786	6.849e-69	241.0	COG1659@1|root,arCOG05909@2157|Archaea,2Y7FS@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Linocin_M18 bacteriocin protein	-	-	-	-	-	-	-	-	-	-	-	-	Linocin_M18
DTH2_k127_3867694_3	593750.Metfor_2787	4.041e-38	148.0	COG1633@1|root,arCOG03349@2157|Archaea	2157|Archaea	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_3867694_4	368407.Memar_2292	0.0004358	51.0	arCOG07468@1|root,arCOG07468@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3867694_2	521011.Mpal_0243	8.902e-51	194.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y29P@28890|Euryarchaeota,2NA5X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3867694_1	593750.Metfor_2626	1.232e-56	205.0	COG2095@1|root,arCOG01997@2157|Archaea	2157|Archaea	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
DTH2_k127_3875295_2	456442.Mboo_0500	1.815e-42	159.0	COG1712@1|root,arCOG00254@2157|Archaea,2XXKF@28890|Euryarchaeota,2N96R@224756|Methanomicrobia	224756|Methanomicrobia	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21,5.3.3.2	ko:K01823,ko:K06989	ko00760,ko00900,ko01100,ko01110,ko01130,map00760,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123,R07407,R07410	RC00455,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF108,NAD_binding_3
DTH2_k127_3875295_1	593750.Metfor_2680	1.776e-48	179.0	arCOG05307@1|root,arCOG05307@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3875295_3	521011.Mpal_2760	4.128e-28	120.0	arCOG06929@1|root,arCOG06929@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3875295_0	593750.Metfor_2678	4.278e-189	599.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,2N93H@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
DTH2_k127_3880792_0	368407.Memar_0553	5.961e-55	212.0	arCOG02903@1|root,arCOG02903@2157|Archaea,2Y1N5@28890|Euryarchaeota,2NA4M@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,VWA
DTH2_k127_3886856_3	694440.JOMF01000005_gene193	1.817e-09	64.0	arCOG07676@1|root,arCOG07676@2157|Archaea	2157|Archaea	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3886856_2	368407.Memar_2384	1.093e-47	176.0	COG0716@1|root,arCOG00519@2157|Archaea,2Y4RJ@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
DTH2_k127_3886856_0	456442.Mboo_0263	0.0	1193.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,2N9FS@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DTH2_k127_3886856_1	323259.Mhun_2829	7.235e-51	182.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,2N9K7@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
DTH2_k127_3887370_2	521011.Mpal_0620	1.009e-07	53.0	arCOG03394@1|root,arCOG03394@2157|Archaea,2Y1QT@28890|Euryarchaeota,2NA3E@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3887370_0	877455.Metbo_2360	6.325e-167	533.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,23NMK@183925|Methanobacteria	183925|Methanobacteria	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
DTH2_k127_3887370_1	304371.MCP_0431	1.76e-19	88.0	COG0347@1|root,arCOG02305@2157|Archaea,2XYN5@28890|Euryarchaeota,2NAXP@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
DTH2_k127_3888673_2	269797.Mbar_A0726	6.994e-35	145.0	arCOG02527@1|root,arCOG02527@2157|Archaea,2XYVG@28890|Euryarchaeota	28890|Euryarchaeota	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
DTH2_k127_3888673_1	368407.Memar_1143	6.296e-92	308.0	COG1082@1|root,arCOG01895@2157|Archaea,2XV4X@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DTH2_k127_3888673_3	679926.Mpet_1662	4.069e-28	116.0	arCOG02866@1|root,arCOG02866@2157|Archaea,2Y8JA@28890|Euryarchaeota,2NB6N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_3888673_0	593750.Metfor_1643	1.607e-112	366.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,2N958@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
DTH2_k127_3891156_0	368407.Memar_0995	2.24e-113	370.0	COG0137@1|root,arCOG00112@2157|Archaea,2XU8K@28890|Euryarchaeota,2N9DR@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
DTH2_k127_3891156_2	368407.Memar_0996	1.413e-49	180.0	COG3576@1|root,arCOG00518@2157|Archaea,2XYMW@28890|Euryarchaeota,2N9U6@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
DTH2_k127_3891156_1	868131.MSWAN_0865	2.585e-64	229.0	COG0122@1|root,arCOG00464@2157|Archaea,2XV7J@28890|Euryarchaeota	28890|Euryarchaeota	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
DTH2_k127_3908898_0	368407.Memar_0417	1.113e-125	409.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,2N9FC@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM NiFe hydrogenase maturation protein HypF	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
DTH2_k127_3908898_2	1077972.ARGLB_008_00440	5.664e-16	85.0	COG2329@1|root,COG2329@2|Bacteria	2|Bacteria	S	heme oxygenase (decyclizing) activity	-	-	-	-	-	-	-	-	-	-	-	-	ABM
DTH2_k127_3908898_1	1444711.CCJF01000004_gene2118	2.811e-37	149.0	COG0266@1|root,COG0266@2|Bacteria,2JGNZ@204428|Chlamydiae	204428|Chlamydiae	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	-	-	-	-	-	-	-	-	-	-	H2TH
DTH2_k127_3932190_1	593750.Metfor_0229	5.868e-31	126.0	COG0467@1|root,arCOG01175@2157|Archaea,2Y7UD@28890|Euryarchaeota,2NBDD@224756|Methanomicrobia	224756|Methanomicrobia	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DTH2_k127_3932190_0	368407.Memar_2157	2.911e-175	557.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N9CH@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
DTH2_k127_3956145_3	641107.CDLVIII_3926	8.288e-14	82.0	COG1266@1|root,COG1266@2|Bacteria,1VPDT@1239|Firmicutes,25D0B@186801|Clostridia,36U54@31979|Clostridiaceae	186801|Clostridia	S	PFAM Abortive infection protein	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DTH2_k127_3956145_0	368407.Memar_0243	3.629e-132	443.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DTH2_k127_3956145_1	368407.Memar_0242	5.854e-113	371.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DTH2_k127_3956145_2	391009.Tmel_1480	2.026e-61	216.0	COG0863@1|root,COG0863@2|Bacteria,2GD2C@200918|Thermotogae	200918|Thermotogae	H	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DTH2_k127_3956759_3	456442.Mboo_1904	4.341e-64	222.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAGM@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DTH2_k127_3956759_2	368407.Memar_2001	3.64e-119	392.0	COG2064@1|root,arCOG01811@2157|Archaea,2Y7HX@28890|Euryarchaeota,2NBK3@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DTH2_k127_3956759_4	368407.Memar_1997	5.068e-54	190.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,2N9W4@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
DTH2_k127_3956759_0	368407.Memar_1998	1.28e-219	712.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
DTH2_k127_3956759_1	368407.Memar_1999	3.768e-209	661.0	COG1492@1|root,arCOG00105@2157|Archaea,2XT04@28890|Euryarchaeota,2N93Y@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
DTH2_k127_3985286_2	593750.Metfor_2050	2.131e-41	157.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota,2NB49@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM TspO MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
DTH2_k127_3985286_3	368407.Memar_1311	1.308e-37	145.0	COG1773@1|root,arCOG04391@2157|Archaea	2157|Archaea	C	Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
DTH2_k127_3985286_0	368407.Memar_1933	4.398e-159	510.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,2N90R@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
DTH2_k127_3985286_1	521011.Mpal_0975	9.414e-93	311.0	COG0572@1|root,arCOG05133@2157|Archaea,2XU2D@28890|Euryarchaeota	28890|Euryarchaeota	F	uridine kinase	udk	-	2.7.1.19,2.7.1.48	ko:K00855,ko:K00876	ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200	M00165,M00166	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
DTH2_k127_4016193_2	521011.Mpal_0395	1.377e-24	103.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,2NA67@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
DTH2_k127_4016193_0	593750.Metfor_0047	5.66e-206	650.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,2N978@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
DTH2_k127_4016193_1	593750.Metfor_0042	1.625e-38	150.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DTH2_k127_4047053_3	368407.Memar_1580	1.057e-10	66.0	arCOG07830@1|root,arCOG07830@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4047053_2	456442.Mboo_1727	6.694e-23	104.0	arCOG07830@1|root,arCOG07830@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4047053_1	456442.Mboo_1726	2.542e-40	154.0	arCOG05310@1|root,arCOG05310@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4047053_0	694440.JOMF01000006_gene372	5.177e-45	164.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,2N94X@224756|Methanomicrobia	224756|Methanomicrobia	J	TGS domain protein	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
DTH2_k127_4091510_0	679926.Mpet_0587	4.213e-186	593.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,2N93B@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0536	AIRS,AIRS_C
DTH2_k127_4109111_1	1041930.Mtc_1820	2.645e-61	218.0	COG2241@1|root,arCOG00650@2157|Archaea,2XZ22@28890|Euryarchaeota,2N9VQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit	cbiE	-	2.1.1.289	ko:K03399	ko00860,ko01100,map00860,map01100	-	R05813,R07775	RC00003,RC02052,RC02053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1492	TP_methylase
DTH2_k127_4109111_0	368407.Memar_0514	9.227e-110	371.0	COG1903@1|root,arCOG04383@2157|Archaea,2XV53@28890|Euryarchaeota,2N9AY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
DTH2_k127_4109111_2	323259.Mhun_3214	5.207e-60	211.0	COG2082@1|root,arCOG02247@2157|Archaea,2XT0S@28890|Euryarchaeota,2N9MJ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Precorrin-8X methylmutase CbiC CobH	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0630	CbiC
DTH2_k127_4110015_1	368407.Memar_1008	2.45e-155	493.0	COG1941@1|root,arCOG02472@2157|Archaea,2XW80@28890|Euryarchaeota,2NAFA@224756|Methanomicrobia	224756|Methanomicrobia	C	F420-non-reducing hydrogenase subunit G	mvhG-1	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
DTH2_k127_4110015_0	368407.Memar_1007	2.427e-204	648.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,2NAHJ@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	mvhA-1	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
DTH2_k127_4110015_3	593750.Metfor_1068	4.617e-49	177.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota,2NB1F@224756|Methanomicrobia	224756|Methanomicrobia	S	Roadblock LC7	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
DTH2_k127_4110015_5	368407.Memar_1005	1.388e-31	142.0	arCOG02605@1|root,arCOG02605@2157|Archaea,2Y4KK@28890|Euryarchaeota,2NB4P@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Roadblock LC7 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
DTH2_k127_4110015_6	368407.Memar_1013	6.791e-05	54.0	arCOG09603@1|root,arCOG09603@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4110015_2	593750.Metfor_1021	1.011e-115	377.0	COG0455@1|root,arCOG00589@2157|Archaea,2XT20@28890|Euryarchaeota,2N9KH@224756|Methanomicrobia	224756|Methanomicrobia	D	TIGRFAM cell division ATPase MinD	-	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	CbiA
DTH2_k127_4110015_4	368407.Memar_2004	2.037e-46	175.0	arCOG09604@1|root,arCOG09604@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4156611_0	593750.Metfor_0405	2.367e-108	377.0	arCOG02350@1|root,arCOG02385@1|root,arCOG02350@2157|Archaea,arCOG02385@2157|Archaea	2157|Archaea	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS,PAS_9,Response_reg
DTH2_k127_4156611_2	679926.Mpet_2523	4.69e-49	198.0	COG0642@1|root,arCOG02352@1|root,arCOG02352@2157|Archaea,arCOG06193@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_9,Response_reg
DTH2_k127_4156611_1	593750.Metfor_1449	1.016e-83	282.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,2N9QD@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM sugar isomerase (SIS)	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
DTH2_k127_4156611_3	593750.Metfor_1448	2.654e-43	160.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9E9@224756|Methanomicrobia	224756|Methanomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH2_k127_4177746_0	368407.Memar_0538	8.867e-108	359.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
DTH2_k127_4177746_1	593750.Metfor_2676	2.8e-101	333.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DTH2_k127_4179495_9	593750.Metfor_2846	8.757e-24	102.0	arCOG05110@1|root,arCOG05110@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4179495_10	593750.Metfor_2847	1.37e-20	93.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota,2NA1I@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DTH2_k127_4179495_0	368407.Memar_1683	3.276e-188	599.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,2N9DZ@224756|Methanomicrobia	224756|Methanomicrobia	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
DTH2_k127_4179495_5	456442.Mboo_1826	6.099e-65	226.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,2N9QK@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
DTH2_k127_4179495_4	368407.Memar_1681	1.878e-88	295.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,2N9HN@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
DTH2_k127_4179495_6	368407.Memar_1680	1.55e-47	180.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,2N9T6@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
DTH2_k127_4179495_8	368407.Memar_1679	3.255e-29	126.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2NA1F@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
DTH2_k127_4179495_1	521011.Mpal_2526	1.158e-129	417.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
DTH2_k127_4179495_3	679926.Mpet_0959	8.643e-94	324.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
DTH2_k127_4179495_7	368407.Memar_1676	2.137e-39	149.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,2N9ZP@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
DTH2_k127_4179495_11	368407.Memar_1675	2.833e-18	90.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
DTH2_k127_4179495_12	694440.JOMF01000005_gene120	1.616e-16	86.0	COG2136@1|root,arCOG03247@2157|Archaea	2157|Archaea	AJ	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
DTH2_k127_4179495_13	368407.Memar_1673	1.504e-10	74.0	COG2892@1|root,arCOG04414@2157|Archaea	2157|Archaea	S	protein conserved in archaea	pcc1	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
DTH2_k127_4179495_2	368407.Memar_1862	1.724e-108	368.0	COG4069@1|root,arCOG03231@2157|Archaea,2XV7V@28890|Euryarchaeota,2N9V3@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2117
DTH2_k127_4216244_0	368407.Memar_0990	7.673e-208	657.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,2N92M@224756|Methanomicrobia	224756|Methanomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2374	CPSase_L_D2,CPSase_L_D3,MGS
DTH2_k127_4216244_1	368407.Memar_0989	2.058e-164	523.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,2N9D1@224756|Methanomicrobia	224756|Methanomicrobia	E	Carbamoyl-phosphate synthase, small chain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
DTH2_k127_4216244_3	456442.Mboo_1198	4.924e-15	82.0	arCOG00527@1|root,arCOG00527@2157|Archaea,2XY97@28890|Euryarchaeota	28890|Euryarchaeota	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT,Lactamase_B
DTH2_k127_4216244_5	1123371.ATXH01000005_gene2138	0.0002024	51.0	COG0491@1|root,COG0491@2|Bacteria,2GHQV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH2_k127_4216244_4	1123371.ATXH01000005_gene2138	5.249e-12	72.0	COG0491@1|root,COG0491@2|Bacteria,2GHQV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH2_k127_4216244_2	593750.Metfor_1389	2.402e-43	163.0	COG1994@1|root,COG3291@1|root,arCOG00614@2157|Archaea,arCOG02510@2157|Archaea,2Y7RP@28890|Euryarchaeota,2NBKZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
DTH2_k127_4225887_4	521011.Mpal_0290	5.036e-68	233.0	COG0016@1|root,arCOG00411@2157|Archaea,2XUJD@28890|Euryarchaeota,2N9CX@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys)	sepS	-	6.1.1.27	ko:K07587	ko00970,map00970	M00360	R08576	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
DTH2_k127_4225887_0	593750.Metfor_2886	1.275e-181	582.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,2N9A9@224756|Methanomicrobia	224756|Methanomicrobia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
DTH2_k127_4225887_3	593750.Metfor_2887	3.816e-72	258.0	COG0512@1|root,arCOG00086@2157|Archaea,2XTES@28890|Euryarchaeota,2N9PV@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DTH2_k127_4225887_1	593750.Metfor_2888	2.692e-112	379.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,2N9AU@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
DTH2_k127_4225887_2	368407.Memar_0074	4.82e-78	271.0	COG0134@1|root,arCOG01088@2157|Archaea,2XTWK@28890|Euryarchaeota,2N9V0@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3621	IGPS
DTH2_k127_4225887_6	368407.Memar_0075	4.976e-52	195.0	COG0135@1|root,arCOG01983@2157|Archaea,2Y0F5@28890|Euryarchaeota,2NASD@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
DTH2_k127_4225887_5	368407.Memar_0076	1.049e-66	233.0	COG0133@1|root,arCOG01433@2157|Archaea,2XUHQ@28890|Euryarchaeota,2N9DF@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH2_k127_4238795_1	521011.Mpal_0945	1.795e-216	680.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,2N95X@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0179	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
DTH2_k127_4238795_3	368407.Memar_2041	6.078e-45	169.0	arCOG07449@1|root,arCOG07449@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4238795_2	335543.Sfum_4051	4.233e-144	468.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
DTH2_k127_4238795_0	593750.Metfor_1953	1.112e-248	779.0	COG0028@1|root,COG1773@1|root,arCOG01999@2157|Archaea,arCOG04391@2157|Archaea,2XWG6@28890|Euryarchaeota,2NBI8@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the TPP enzyme family	-	-	1.2.3.3	ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207	RC02745	ko00000,ko00001,ko01000	-	-	-	Rubredoxin,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DTH2_k127_4238795_4	593750.Metfor_1733	1.965e-17	85.0	COG1002@1|root,COG2810@1|root,arCOG02636@1|root,arCOG08946@1|root,arCOG02635@2157|Archaea,arCOG02636@2157|Archaea,arCOG05724@2157|Archaea,arCOG08946@2157|Archaea,2Y89V@28890|Euryarchaeota	28890|Euryarchaeota	LV	Type I restriction-modification system methyltransferase subunit	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,HSDR_N,N6_Mtase,TaqI_C
DTH2_k127_4294796_2	593750.Metfor_0585	3.319e-19	89.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
DTH2_k127_4294796_0	368407.Memar_1848	1.218e-157	504.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,2N9FF@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis	mfnA	-	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
DTH2_k127_4294796_1	593750.Metfor_0588	4.283e-42	156.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DTH2_k127_43100_2	323259.Mhun_2259	2.367e-27	113.0	COG1693@1|root,arCOG02710@2157|Archaea,2XVGZ@28890|Euryarchaeota,2N90G@224756|Methanomicrobia	224756|Methanomicrobia	K	Ribonuclease R winged-helix domain	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
DTH2_k127_43100_1	368407.Memar_0554	7.639e-53	192.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y071@28890|Euryarchaeota,2N9T7@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM deoxycytidine triphosphate deaminase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
DTH2_k127_43100_0	368407.Memar_0553	1.001e-60	226.0	arCOG02903@1|root,arCOG02903@2157|Archaea,2Y1N5@28890|Euryarchaeota,2NA4M@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,VWA
DTH2_k127_4338837_0	410358.Mlab_1393	5.741e-69	240.0	COG0159@1|root,arCOG01086@2157|Archaea,2XTAW@28890|Euryarchaeota,2N9KY@224756|Methanomicrobia	224756|Methanomicrobia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
DTH2_k127_4338837_1	909663.KI867150_gene17	3.509e-40	155.0	COG1618@1|root,COG1618@2|Bacteria,1N4XQ@1224|Proteobacteria,430FS@68525|delta/epsilon subdivisions,2WW2Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	NTPase	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_1
DTH2_k127_4338837_2	593750.Metfor_2848	8.377e-25	106.0	COG1205@1|root,arCOG00555@2157|Archaea,2XTPR@28890|Euryarchaeota,2N96V@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
DTH2_k127_4345533_1	368407.Memar_0968	4.936e-84	282.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,2N9MI@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
DTH2_k127_4345533_3	368407.Memar_1014	1.24e-33	136.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0UT@28890|Euryarchaeota,2NB7J@224756|Methanomicrobia	224756|Methanomicrobia	C	Hydrogenase maturation protease	vhtD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
DTH2_k127_4345533_2	456442.Mboo_1353	2.627e-64	226.0	COG2061@1|root,arCOG04396@2157|Archaea,2XWMD@28890|Euryarchaeota,2N9PF@224756|Methanomicrobia	224756|Methanomicrobia	E	amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4345533_0	521011.Mpal_1993	3.257e-126	429.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,2N91A@224756|Methanomicrobia	224756|Methanomicrobia	E	homoserine dehydrogenase	thrA	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
DTH2_k127_4349751_1	368407.Memar_2190	3.376e-53	193.0	COG2229@1|root,arCOG00362@2157|Archaea,2XZ9P@28890|Euryarchaeota,2NB59@224756|Methanomicrobia	224756|Methanomicrobia	S	Ras family	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	GTP_EFTU
DTH2_k127_4349751_4	593750.Metfor_1636	5.276e-15	80.0	arCOG08228@1|root,arCOG08228@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4349751_0	368407.Memar_1539	1.448e-206	658.0	COG1001@1|root,arCOG00693@2157|Archaea,2XV8C@28890|Euryarchaeota,2NACW@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
DTH2_k127_4349751_2	1047013.AQSP01000126_gene2742	1.26e-32	138.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD,Glutaredoxin,SfLAP
DTH2_k127_44710_3	521011.Mpal_2730	2.668e-69	243.0	COG1473@1|root,arCOG01108@2157|Archaea,2XV81@28890|Euryarchaeota,2N9WP@224756|Methanomicrobia	224756|Methanomicrobia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
DTH2_k127_44710_5	679926.Mpet_0718	2.042e-34	134.0	COG4802@1|root,arCOG01099@2157|Archaea,2Y0XX@28890|Euryarchaeota,2NA12@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
DTH2_k127_44710_1	679926.Mpet_0717	1.327e-109	359.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,2N9HC@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
DTH2_k127_44710_6	521011.Mpal_0978	1.877e-19	95.0	COG1828@1|root,arCOG04462@2157|Archaea,2XYPB@28890|Euryarchaeota,2NA2T@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
DTH2_k127_44710_2	593750.Metfor_0518	3.125e-89	301.0	COG0152@1|root,arCOG04421@2157|Archaea,2XUKC@28890|Euryarchaeota,2N9F8@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosylaminoimidazolesuccinocarboxamide synthase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
DTH2_k127_44710_0	593750.Metfor_0519	3.506e-147	471.0	COG1060@1|root,arCOG00657@2157|Archaea,2XT78@28890|Euryarchaeota,2N94M@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofG	-	2.5.1.77	ko:K11780	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
DTH2_k127_44710_4	679926.Mpet_0719	2.527e-67	239.0	COG1920@1|root,arCOG04472@2157|Archaea,2XX3C@28890|Euryarchaeota,2N9RG@224756|Methanomicrobia	224756|Methanomicrobia	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
DTH2_k127_4478441_0	593750.Metfor_1238	1.591e-52	192.0	COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DTH2_k127_4478441_1	107635.AZUO01000001_gene3435	2.634e-09	70.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_11,TPR_16,TPR_2,TPR_8
DTH2_k127_4495571_0	593750.Metfor_2848	1.088e-244	769.0	COG1205@1|root,arCOG00555@2157|Archaea,2XTPR@28890|Euryarchaeota,2N96V@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
DTH2_k127_4539359_2	368407.Memar_0282	2.704e-178	572.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DTH2_k127_4539359_6	456442.Mboo_2349	3.907e-16	81.0	COG0636@1|root,arCOG02455@2157|Archaea,2XZRP@28890|Euryarchaeota,2N9ZA@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM H transporting two-sector ATPase C subunit	atpK-1	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0390	ATP-synt_C
DTH2_k127_4539359_4	593750.Metfor_0312	1.851e-52	191.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,2N9TB@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
DTH2_k127_4539359_3	368407.Memar_0285	3.465e-110	366.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
DTH2_k127_4539359_5	368407.Memar_0286	1.2e-43	160.0	COG1436@1|root,arCOG04102@2157|Archaea,2XXYI@28890|Euryarchaeota,2N9YY@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
DTH2_k127_4539359_0	593750.Metfor_0315	3.161e-316	978.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
DTH2_k127_4539359_1	368407.Memar_0288	1.014e-244	762.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2N97D@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DTH2_k127_4604225_1	871968.DESME_14475	8.322e-46	179.0	COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia	186801|Clostridia	M	Group 1 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
DTH2_k127_4604225_0	1121946.AUAX01000001_gene2584	1.545e-70	243.0	COG0451@1|root,COG0451@2|Bacteria,2I2ZM@201174|Actinobacteria,4DCFS@85008|Micromonosporales	201174|Actinobacteria	M	Male sterility protein	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678,ko:K21211	ko00520,ko00521,ko00523,ko00525,ko01055,ko01059,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01059,map01100,map01130	M00361,M00793	R01384,R06513,R11430	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
DTH2_k127_4619629_2	456442.Mboo_0857	2.639e-83	278.0	COG0154@1|root,arCOG01717@2157|Archaea,2XTV3@28890|Euryarchaeota,2N94U@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
DTH2_k127_4619629_1	368407.Memar_0771	7.356e-207	660.0	COG0064@1|root,arCOG01718@2157|Archaea,2XSV3@28890|Euryarchaeota,2N981@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
DTH2_k127_4619629_0	368407.Memar_0770	1.714e-209	664.0	COG0550@1|root,arCOG00416@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,2N96B@224756|Methanomicrobia	224756|Methanomicrobia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
DTH2_k127_4778913_0	593750.Metfor_0603	1.845e-217	685.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,2N968@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
DTH2_k127_4794365_0	593750.Metfor_0937	1.382e-123	413.0	COG1122@1|root,arCOG00203@2157|Archaea,2Y7N4@28890|Euryarchaeota,2N9IS@224756|Methanomicrobia	224756|Methanomicrobia	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	iAF692.Mbar_A2149	ABC_tran
DTH2_k127_4794365_1	593750.Metfor_0936	3.359e-89	301.0	COG0619@1|root,arCOG02249@2157|Archaea,2XUZN@28890|Euryarchaeota,2NAC2@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
DTH2_k127_4887208_2	368407.Memar_0854	1.424e-94	313.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,2N9BR@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
DTH2_k127_4887208_1	368407.Memar_0853	2.652e-171	550.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2N97V@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
DTH2_k127_4887208_0	368407.Memar_0852	9.482e-180	583.0	COG0165@1|root,arCOG01748@2157|Archaea,2XUWS@28890|Euryarchaeota,2N9AC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
DTH2_k127_4887208_3	593750.Metfor_2407	4.342e-72	254.0	COG4800@1|root,arCOG04375@2157|Archaea,2XXJS@28890|Euryarchaeota,2N9MB@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DTH2_k127_4887208_4	521011.Mpal_1077	1.218e-55	201.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV0M@28890|Euryarchaeota	28890|Euryarchaeota	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
DTH2_k127_4914212_2	368407.Memar_2451	7.842e-13	69.0	arCOG03400@1|root,arCOG03400@2157|Archaea	2157|Archaea	F	nucleic acid binding OB-fold tRNA helicase-type	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-codon
DTH2_k127_4914212_0	521011.Mpal_0053	1.592e-72	270.0	COG0642@1|root,arCOG06712@1|root,arCOG06940@1|root,arCOG06192@2157|Archaea,arCOG06712@2157|Archaea,arCOG06940@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_9,Response_reg
DTH2_k127_4914212_1	521011.Mpal_0407	8.872e-48	179.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2XZME@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_4930388_0	368407.Memar_1968	5.537e-78	267.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,2N9JT@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
DTH2_k127_4930388_3	521011.Mpal_0539	1.083e-34	134.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,2N9YU@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL31 family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
DTH2_k127_4930388_4	368407.Memar_1970	5.855e-18	85.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota,2NA3D@224756|Methanomicrobia	224756|Methanomicrobia	J	structural constituent of ribosome	rpl39e	-	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
DTH2_k127_4930388_2	694440.JOMF01000008_gene939	1.365e-37	143.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
DTH2_k127_4930388_1	521011.Mpal_0535	9.69e-58	205.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,2N9QY@224756|Methanomicrobia	224756|Methanomicrobia	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
DTH2_k127_4930388_5	368407.Memar_1974	5.986e-10	61.0	COG1534@1|root,arCOG01346@2157|Archaea,2Y6W9@28890|Euryarchaeota,2NA5I@224756|Methanomicrobia	224756|Methanomicrobia	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
DTH2_k127_50213_1	521011.Mpal_1563	4.034e-76	261.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,2N9BJ@224756|Methanomicrobia	224756|Methanomicrobia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	aor-2	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH2_k127_50213_0	323259.Mhun_3049	2.285e-146	473.0	COG0492@1|root,arCOG01297@2157|Archaea,2Y84N@28890|Euryarchaeota,2N9Q1@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB-1	-	1.8.1.9	ko:K00384,ko:K03387	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
DTH2_k127_50213_2	456442.Mboo_1250	1.509e-62	220.0	COG0642@1|root,arCOG03932@1|root,arCOG03932@2157|Archaea,arCOG06192@2157|Archaea	2157|Archaea	T	TIGRFAM PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HTH_11,HTH_IclR,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DTH2_k127_5046996_2	456442.Mboo_0055	5.096e-29	119.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,2N9NP@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
DTH2_k127_5046996_1	368407.Memar_0057	3.897e-68	247.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,2N9J0@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM riboflavin synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
DTH2_k127_5046996_0	368407.Memar_0056	1.035e-165	529.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,2N9EM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
DTH2_k127_5059005_2	694440.JOMF01000004_gene1332	6.696e-84	281.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,2N9B7@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,RIO1
DTH2_k127_5059005_8	679926.Mpet_0096	1.682e-21	94.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,2NA60@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
DTH2_k127_5059005_6	593750.Metfor_2871	1.43e-25	110.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,2NA0E@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
DTH2_k127_5059005_3	368407.Memar_2244	6.276e-54	197.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
DTH2_k127_5059005_7	593750.Metfor_2869	7.049e-25	106.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
DTH2_k127_5059005_1	593750.Metfor_2868	1.717e-89	306.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,2N9GJ@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
DTH2_k127_5059005_4	368407.Memar_2241	2.853e-34	142.0	COG1412@1|root,arCOG04312@2157|Archaea,2XX55@28890|Euryarchaeota,2N9V2@224756|Methanomicrobia	224756|Methanomicrobia	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
DTH2_k127_5059005_0	368407.Memar_2240	9.149e-210	657.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,2N93K@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
DTH2_k127_5059005_5	368407.Memar_2239	2.283e-30	128.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
DTH2_k127_5063571_1	304371.MCP_1230	1.129e-63	230.0	COG3527@1|root,arCOG03340@2157|Archaea,2XUAU@28890|Euryarchaeota,2NARS@224756|Methanomicrobia	224756|Methanomicrobia	Q	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
DTH2_k127_5063571_2	679926.Mpet_0106	8.725e-38	151.0	2CBFN@1|root,2N56J@2157|Archaea,2Y3WE@28890|Euryarchaeota,2NAWP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5063571_0	593750.Metfor_1488	2.105e-135	437.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
DTH2_k127_5079946_1	593750.Metfor_1608	7.412e-69	238.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,2N9J9@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3
DTH2_k127_5079946_0	521011.Mpal_1731	6.698e-96	318.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,2N9G7@224756|Methanomicrobia	224756|Methanomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
DTH2_k127_5082469_5	593750.Metfor_1325	2.626e-25	117.0	arCOG04998@1|root,arCOG04998@2157|Archaea,2XZR1@28890|Euryarchaeota,2N9VB@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5082469_0	593750.Metfor_1326	9.272e-218	684.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,2N90W@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
DTH2_k127_5082469_3	368407.Memar_1652	1.845e-30	126.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,2NA1Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
DTH2_k127_5082469_6	368407.Memar_1653	6.617e-23	104.0	arCOG05136@1|root,arCOG05136@2157|Archaea,2Y1BS@28890|Euryarchaeota,2NA5R@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5082469_4	368407.Memar_1654	5.728e-29	121.0	arCOG04419@1|root,arCOG04419@2157|Archaea,2XZTP@28890|Euryarchaeota,2N9ZJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2551)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2551
DTH2_k127_5082469_2	593750.Metfor_1330	4.323e-87	297.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,2N9GN@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
DTH2_k127_5082469_1	521011.Mpal_1023	7.125e-101	338.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,2N9BA@224756|Methanomicrobia	224756|Methanomicrobia	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
DTH2_k127_5103878_1	368407.Memar_0973	1.616e-106	351.0	COG5423@1|root,arCOG04361@2157|Archaea,2Y00P@28890|Euryarchaeota	28890|Euryarchaeota	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
DTH2_k127_5103878_2	679926.Mpet_0560	6.337e-53	192.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,2N9R9@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
DTH2_k127_5103878_3	593750.Metfor_2902	1.526e-36	143.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,2N9TM@224756|Methanomicrobia	224756|Methanomicrobia	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
DTH2_k127_5103878_0	368407.Memar_2299	3.903e-167	533.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,2N967@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
DTH2_k127_5109127_1	368407.Memar_2438	5.742e-14	81.0	arCOG04662@1|root,arCOG04662@2157|Archaea,2XU93@28890|Euryarchaeota,2NBCG@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5109127_0	679926.Mpet_0795	1.018e-73	256.0	COG1408@1|root,arCOG01156@2157|Archaea,2XYFR@28890|Euryarchaeota,2NBCE@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
DTH2_k127_5110700_0	1094980.Mpsy_1815	7.733e-152	491.0	COG0422@1|root,arCOG02741@2157|Archaea,2Y2NF@28890|Euryarchaeota,2NAHH@224756|Methanomicrobia	224756|Methanomicrobia	H	Radical SAM ThiC family	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
DTH2_k127_5110700_2	593750.Metfor_1052	7.918e-37	145.0	arCOG13108@1|root,arCOG13108@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5110700_1	368407.Memar_1251	1.069e-104	344.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
DTH2_k127_5132185_3	368407.Memar_1051	7.736e-19	92.0	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
DTH2_k127_5132185_1	593750.Metfor_0365	3.569e-132	430.0	COG1668@1|root,arCOG01470@2157|Archaea,2XU06@28890|Euryarchaeota,2N9QX@224756|Methanomicrobia	224756|Methanomicrobia	C	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
DTH2_k127_5132185_0	593750.Metfor_0366	2.808e-204	652.0	COG1668@1|root,arCOG04450@2157|Archaea,2XTRJ@28890|Euryarchaeota,2N9IA@224756|Methanomicrobia	224756|Methanomicrobia	C	COG1668 ABC-type Na efflux pump, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
DTH2_k127_5132185_2	456442.Mboo_2285	3.079e-112	369.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUT0@28890|Euryarchaeota,2N9J5@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DTH2_k127_513697_1	521011.Mpal_1201	2.639e-119	394.0	COG1361@1|root,arCOG02079@2157|Archaea,2XTCZ@28890|Euryarchaeota,2NBGV@224756|Methanomicrobia	224756|Methanomicrobia	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_513697_2	368407.Memar_0485	1.701e-87	294.0	COG2140@1|root,arCOG02602@2157|Archaea,2XWS8@28890|Euryarchaeota,2N9IM@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Glucose-6-phosphate isomerase	gpi	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
DTH2_k127_513697_0	521011.Mpal_1196	9.174e-144	471.0	COG1226@1|root,arCOG01960@2157|Archaea,2XTQV@28890|Euryarchaeota,2N9KX@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM TrkA-N domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
DTH2_k127_5139716_0	456442.Mboo_0910	5.356e-99	329.0	COG4083@1|root,arCOG04471@2157|Archaea,2XTQZ@28890|Euryarchaeota,2N9VN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
DTH2_k127_5139716_1	1321773.HMPREF9069_01022	1.648e-12	76.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4CV13@84998|Coriobacteriia	84998|Coriobacteriia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DTH2_k127_5139716_2	521011.Mpal_2093	1.811e-07	53.0	COG0558@1|root,arCOG00670@2157|Archaea,2XZF4@28890|Euryarchaeota,2NAX5@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
DTH2_k127_5146523_0	593750.Metfor_0296	2.401e-147	478.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DTH2_k127_5146523_1	406327.Mevan_0797	5.73e-20	92.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,23Q6F@183939|Methanococci	183939|Methanococci	L	PFAM peptidase U62 modulator of DNA gyrase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DTH2_k127_5175652_4	593750.Metfor_2711	5.456e-141	451.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,2N98K@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
DTH2_k127_5175652_3	368407.Memar_2173	5.919e-156	498.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,2N944@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
DTH2_k127_5175652_0	192952.MM_3045	2.957e-274	846.0	COG0374@1|root,arCOG01549@2157|Archaea,2XSXP@28890|Euryarchaeota,2N964@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	frhA-1	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.98.1	ko:K00440	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
DTH2_k127_5175652_5	868131.MSWAN_2264	2.232e-45	170.0	COG0680@1|root,arCOG04429@2157|Archaea,2XY3C@28890|Euryarchaeota,23P27@183925|Methanobacteria	183925|Methanobacteria	C	Coenzyme F420-reducing hydrogenase, delta subunit	frhD	-	-	ko:K00442	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001	-	-	-	HycI
DTH2_k127_5175652_1	192952.MM_3043	6.916e-169	532.0	COG1941@1|root,arCOG02473@2157|Archaea,2XUXH@28890|Euryarchaeota,2N9H2@224756|Methanomicrobia	224756|Methanomicrobia	C	NADH ubiquinone oxidoreductase 20 kDa subunit	frhG-1	-	1.12.98.1	ko:K00443	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Oxidored_q6
DTH2_k127_5175652_2	192952.MM_3042	8.343e-160	507.0	COG1035@1|root,arCOG02651@2157|Archaea,2XUH6@28890|Euryarchaeota,2NA7E@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit	frhB-2	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2290	FrhB_FdhB_C,FrhB_FdhB_N
DTH2_k127_5176584_0	521011.Mpal_0276	3.529e-121	392.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2N94I@224756|Methanomicrobia	224756|Methanomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DTH2_k127_5176584_1	368407.Memar_2152	2.252e-117	388.0	COG0620@1|root,arCOG01876@2157|Archaea,2XUCW@28890|Euryarchaeota,2NAQD@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Methionine synthase, vitamin-B12 independent	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
DTH2_k127_5176584_2	593750.Metfor_0229	8.831e-25	106.0	COG0467@1|root,arCOG01175@2157|Archaea,2Y7UD@28890|Euryarchaeota,2NBDD@224756|Methanomicrobia	224756|Methanomicrobia	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DTH2_k127_5183834_2	368407.Memar_0150	5.171e-78	269.0	COG1397@1|root,arCOG04448@2157|Archaea,2XV15@28890|Euryarchaeota,2NB9I@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
DTH2_k127_5183834_0	593750.Metfor_0084	3.906e-165	524.0	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,2N9EF@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DTH2_k127_5183834_3	368407.Memar_0152	5.957e-55	198.0	COG0517@1|root,arCOG00606@2157|Archaea,2XZ85@28890|Euryarchaeota,2N9UA@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH2_k127_5183834_1	593750.Metfor_0083	2.956e-152	498.0	COG1364@1|root,arCOG04413@2157|Archaea,2XUG6@28890|Euryarchaeota,2N99N@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2003	ArgJ
DTH2_k127_5183834_4	368407.Memar_0154	1.231e-14	84.0	COG0548@1|root,arCOG00862@2157|Archaea,2XTW9@28890|Euryarchaeota,2N912@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
DTH2_k127_5184454_2	456442.Mboo_0486	1.843e-39	158.0	COG0464@1|root,arCOG04368@2157|Archaea,2XT63@28890|Euryarchaeota,2N9B2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
DTH2_k127_5184454_1	368407.Memar_2090	1.763e-111	373.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DTH2_k127_5184454_0	368407.Memar_2091	2.853e-127	424.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
DTH2_k127_5184454_3	456442.Mboo_0490	1.899e-27	120.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,2N9YC@224756|Methanomicrobia	224756|Methanomicrobia	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5223789_0	368407.Memar_1619	2.973e-138	450.0	COG0433@1|root,arCOG00280@2157|Archaea,2XZQZ@28890|Euryarchaeota,2NB38@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
DTH2_k127_5234363_0	593750.Metfor_0948	0.0	1043.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9W@28890|Euryarchaeota,2NAP6@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
DTH2_k127_5234363_2	795359.TOPB45_1234	4.14e-10	61.0	COG2059@1|root,COG2059@2|Bacteria,2GHF7@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DTH2_k127_5302901_1	368407.Memar_1200	2.807e-60	218.0	COG0477@1|root,arCOG00130@2157|Archaea,2XZC7@28890|Euryarchaeota,2N9WS@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH2_k127_5302901_0	351160.LRC454	5.046e-126	421.0	arCOG04580@1|root,arCOG04580@2157|Archaea,2XUWY@28890|Euryarchaeota,2NA9J@224756|Methanomicrobia	224756|Methanomicrobia	Q	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
DTH2_k127_5330555_1	593750.Metfor_2681	3.47e-49	179.0	COG1321@1|root,arCOG02100@2157|Archaea,2XXXA@28890|Euryarchaeota,2N9RI@224756|Methanomicrobia	224756|Methanomicrobia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
DTH2_k127_5330555_0	593750.Metfor_2682	8.181e-79	271.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y8G4@28890|Euryarchaeota	28890|Euryarchaeota	P	Cobalt transport protein	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
DTH2_k127_5330555_2	593750.Metfor_2683	3.521e-32	129.0	COG1122@1|root,arCOG00202@2157|Archaea,2XT28@28890|Euryarchaeota	28890|Euryarchaeota	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
DTH2_k127_535762_1	368407.Memar_2214	2.391e-44	164.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,2N9E5@224756|Methanomicrobia	224756|Methanomicrobia	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
DTH2_k127_535762_0	368407.Memar_2213	1.068e-220	697.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DTH2_k127_535762_2	368407.Memar_2212	4.478e-11	63.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,2N9BK@224756|Methanomicrobia	224756|Methanomicrobia	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
DTH2_k127_5359087_0	521011.Mpal_1222	1.184e-118	393.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota	28890|Euryarchaeota	O	AIR synthase related protein domain protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
DTH2_k127_5359087_2	521011.Mpal_1221	1.922e-78	267.0	COG1992@1|root,arCOG00021@2157|Archaea,2Y3P5@28890|Euryarchaeota,2NAWT@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine-phosphate synthase	-	-	2.5.1.3	ko:K21220	ko00730,ko01100,map00730,map01100	-	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	ThiP_synth
DTH2_k127_5359087_5	593750.Metfor_0802	2.647e-09	64.0	COG2104@1|root,arCOG00535@2157|Archaea	2157|Archaea	H	Sulfur transfer protein involved in thiamine biosynthesis	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DTH2_k127_5359087_3	593750.Metfor_0803	2.801e-78	270.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,2N92N@224756|Methanomicrobia	224756|Methanomicrobia	D	PFAM PP-loop domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
DTH2_k127_5359087_1	521011.Mpal_1216	8.019e-79	270.0	COG1526@1|root,arCOG04358@2157|Archaea,2XYNI@28890|Euryarchaeota,2NAIN@224756|Methanomicrobia	224756|Methanomicrobia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
DTH2_k127_5359087_4	456442.Mboo_1984	4.587e-62	217.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2N94V@224756|Methanomicrobia	224756|Methanomicrobia	E	DegT/DnrJ/EryC1/StrS aminotransferase family	nifS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
DTH2_k127_5381519_3	694440.JOMF01000006_gene563	1.595e-05	48.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
DTH2_k127_5381519_0	368407.Memar_0646	1.301e-192	610.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,2N9AH@224756|Methanomicrobia	224756|Methanomicrobia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
DTH2_k127_5381519_2	456442.Mboo_0849	2.785e-40	161.0	arCOG05283@1|root,arCOG05283@2157|Archaea,2XZM2@28890|Euryarchaeota,2NAVF@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5381519_1	368407.Memar_0645	1.276e-118	384.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,2N987@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1514	His_biosynth
DTH2_k127_5389918_2	410358.Mlab_0681	6.495e-59	208.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2N96Q@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DTH2_k127_5389918_1	679926.Mpet_0760	1.56e-71	253.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,2N9PA@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DTH2_k127_5389918_0	368407.Memar_1814	1.496e-77	275.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,2N94G@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
DTH2_k127_5458468_1	368407.Memar_1645	1.214e-62	233.0	COG1122@1|root,arCOG00188@2157|Archaea	2157|Archaea	P	PFAM ABC transporter related	phnG	-	2.7.8.37	ko:K02068,ko:K03529,ko:K06166,ko:K16786,ko:K16787	ko00440,ko02010,map00440,map02010	M00211,M00582	R10185	RC00005,RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko03036	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,PhnG,SMC_N,SMC_hinge
DTH2_k127_5458468_0	368407.Memar_1646	1.894e-66	233.0	COG3839@1|root,arCOG00211@2157|Archaea	2157|Archaea	G	PFAM ABC transporter	-	-	-	ko:K16786	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
DTH2_k127_5458468_2	593750.Metfor_1322	1.044e-54	196.0	COG1268@1|root,arCOG02986@2157|Archaea,2XWSG@28890|Euryarchaeota,2N9UN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM BioY protein	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
DTH2_k127_5458468_3	521011.Mpal_1015	9.613e-42	164.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,2N982@224756|Methanomicrobia	224756|Methanomicrobia	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
DTH2_k127_5458468_4	521011.Mpal_1015	9.603e-19	87.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,2N982@224756|Methanomicrobia	224756|Methanomicrobia	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
DTH2_k127_5488299_0	593750.Metfor_2226	1.432e-125	406.0	COG2899@1|root,arCOG05299@2157|Archaea,2Y4HF@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
DTH2_k127_5488299_1	521011.Mpal_0407	3.518e-50	186.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2XZME@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5488299_2	926560.KE387025_gene4022	6.143e-39	154.0	COG0642@1|root,COG5000@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1WM0R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4
DTH2_k127_5526772_1	679926.Mpet_2292	2.423e-80	270.0	COG0641@1|root,arCOG00945@2157|Archaea,2XV96@28890|Euryarchaeota,2NABU@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DTH2_k127_5526772_0	593750.Metfor_2560	7.045e-112	370.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
DTH2_k127_5526772_2	521011.Mpal_0572	9.645e-68	237.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,2N92W@224756|Methanomicrobia	224756|Methanomicrobia	J	sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
DTH2_k127_5585995_0	368407.Memar_0939	1.266e-182	579.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,2N9CQ@224756|Methanomicrobia	224756|Methanomicrobia	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
DTH2_k127_5601808_2	304371.MCP_2292	1.777e-89	301.0	COG1394@1|root,arCOG04101@2157|Archaea,2Y394@28890|Euryarchaeota,2NA8W@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD-2	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
DTH2_k127_5601808_1	304371.MCP_2291	1.937e-251	783.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2NAB4@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB-2	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DTH2_k127_5601808_0	1041930.Mtc_2334	3.98e-297	919.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2NANC@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA-2	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
DTH2_k127_5601808_5	869210.Marky_1601	1.177e-12	72.0	COG1436@1|root,COG1436@2|Bacteria,1WKHR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
DTH2_k127_5601808_3	1041930.Mtc_2336	6.113e-45	168.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DTH2_k127_5615127_2	368407.Memar_0752	6.398e-27	121.0	COG1254@1|root,arCOG01674@2157|Archaea,2XYT5@28890|Euryarchaeota,2NA46@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the acylphosphatase family	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
DTH2_k127_5615127_0	521011.Mpal_2167	1.411e-263	853.0	COG0457@1|root,arCOG03827@2157|Archaea	2157|Archaea	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12
DTH2_k127_5615127_1	368407.Memar_0755	8.743e-158	507.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DTH2_k127_5679747_1	877455.Metbo_2037	3.29e-59	213.0	COG0069@1|root,arCOG03896@1|root,arCOG00619@2157|Archaea,arCOG03896@2157|Archaea,2Y7H6@28890|Euryarchaeota,23PHC@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769,Glu_synthase
DTH2_k127_5679747_2	304371.MCP_1544	9.886e-36	143.0	COG0642@1|root,COG2202@1|root,arCOG06192@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea,2Y3CS@28890|Euryarchaeota,2NAS5@224756|Methanomicrobia	224756|Methanomicrobia	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_3,PAS_4,PAS_9,Response_reg
DTH2_k127_5679747_0	593750.Metfor_2574	3.792e-83	278.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,2N9NF@224756|Methanomicrobia	224756|Methanomicrobia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
DTH2_k127_5679747_3	192952.MM_2856	1.371e-34	138.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT2Y@28890|Euryarchaeota,2N9GE@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH2_k127_5707549_0	593750.Metfor_2417	1.275e-122	406.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
DTH2_k127_5779245_1	593750.Metfor_1522	6.287e-19	93.0	arCOG08229@1|root,arCOG08229@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
DTH2_k127_5779245_0	593750.Metfor_1523	3.14e-94	323.0	arCOG08225@1|root,arCOG08225@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_5823456_0	368407.Memar_1849	3.795e-297	919.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DTH2_k127_5827191_1	269797.Mbar_A0508	5.408e-69	239.0	COG1541@1|root,arCOG02622@2157|Archaea,2XVU6@28890|Euryarchaeota,2N93X@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
DTH2_k127_5827191_0	368407.Memar_1194	1.403e-108	366.0	COG1478@1|root,arCOG02714@2157|Archaea,2XTHI@28890|Euryarchaeota,2N9KE@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
DTH2_k127_5827191_2	323259.Mhun_1311	2.68e-66	228.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota,2NBII@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_591238_2	368407.Memar_0466	5.483e-38	147.0	arCOG06570@1|root,arCOG06570@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_591238_3	368407.Memar_0465	7.037e-38	152.0	COG3612@1|root,arCOG04418@2157|Archaea,2XXT8@28890|Euryarchaeota,2NA4A@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
DTH2_k127_591238_1	593750.Metfor_0355	3.12e-44	165.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2N9XB@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
DTH2_k127_591238_0	456442.Mboo_2294	1.285e-273	852.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,2N96H@224756|Methanomicrobia	224756|Methanomicrobia	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
DTH2_k127_591238_4	593750.Metfor_0592	1.387e-30	132.0	arCOG06510@1|root,arCOG06510@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
DTH2_k127_591238_5	323259.Mhun_0760	6.541e-06	53.0	COG1361@1|root,arCOG02080@2157|Archaea,2Y0I6@28890|Euryarchaeota,2N9ZF@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
DTH2_k127_5913172_2	679926.Mpet_1203	1.953e-14	73.0	COG1096@1|root,arCOG00676@2157|Archaea	2157|Archaea	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
DTH2_k127_5913172_1	521011.Mpal_2246	1.248e-30	123.0	arCOG05509@1|root,arCOG05509@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1922
DTH2_k127_5913172_3	593750.Metfor_1829	6.237e-14	72.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y6WB@28890|Euryarchaeota,2NA5T@224756|Methanomicrobia	224756|Methanomicrobia	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
DTH2_k127_5913172_0	521011.Mpal_0781	4.312e-118	389.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,2N9II@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	A_deaminase,Amidohydro_1
DTH2_k127_6189465_1	593750.Metfor_2684	4.274e-68	236.0	COG0310@1|root,arCOG02248@2157|Archaea,2XTXA@28890|Euryarchaeota	28890|Euryarchaeota	P	Cobalt uptake substrate-specific transmembrane region	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
DTH2_k127_6189465_0	323259.Mhun_0627	1.239e-160	515.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,2N946@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
DTH2_k127_6201456_0	593750.Metfor_1478	3.037e-66	239.0	COG2243@1|root,arCOG00648@2157|Archaea,2XTS5@28890|Euryarchaeota,2N9NT@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
DTH2_k127_6201456_1	368407.Memar_0508	5.162e-45	168.0	COG2242@1|root,arCOG00977@2157|Archaea,2XVKZ@28890|Euryarchaeota,2N9SF@224756|Methanomicrobia	224756|Methanomicrobia	Q	Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7	cbiT	-	2.1.1.196	ko:K02191	ko00860,map00860	-	R05813,R07774	RC00003,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	Methyltransf_18,Methyltransf_25,Methyltransf_31
DTH2_k127_6201456_2	593750.Metfor_0232	3.049e-16	85.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2N94I@224756|Methanomicrobia	224756|Methanomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DTH2_k127_6342740_0	593750.Metfor_1238	1.813e-246	772.0	COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DTH2_k127_6342740_2	593750.Metfor_1237	6.392e-23	99.0	COG3350@1|root,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
DTH2_k127_6342740_1	456442.Mboo_1055	1.108e-52	191.0	COG0693@1|root,arCOG00769@2157|Archaea,2XTPH@28890|Euryarchaeota,2N9U0@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
DTH2_k127_6352802_0	368407.Memar_2124	0.0	1032.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,2N91E@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
DTH2_k127_6358725_1	456442.Mboo_1684	1.959e-76	269.0	arCOG05290@1|root,arCOG05290@2157|Archaea,2Y58D@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6358725_0	368407.Memar_1935	1.255e-145	486.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
DTH2_k127_6358725_2	593750.Metfor_1614	1.499e-51	206.0	COG1624@1|root,arCOG02348@1|root,arCOG02385@1|root,arCOG02348@2157|Archaea,arCOG02385@2157|Archaea,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota	28890|Euryarchaeota	T	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N,PK_C
DTH2_k127_6358725_3	269797.Mbar_A2710	1.403e-42	156.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,2N9EN@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
DTH2_k127_6369691_1	593750.Metfor_0202	1.294e-101	336.0	COG0367@1|root,arCOG00071@2157|Archaea,2XV5E@28890|Euryarchaeota,2N9BC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	asnB-1	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
DTH2_k127_6369691_0	368407.Memar_0252	5.011e-149	488.0	COG0433@1|root,arCOG06224@2157|Archaea,2XTGF@28890|Euryarchaeota,2NBMY@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF87	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
DTH2_k127_6369834_0	368407.Memar_0948	1.347e-170	551.0	COG1955@1|root,arCOG01809@2157|Archaea,2XTAX@28890|Euryarchaeota,2N9WG@224756|Methanomicrobia	224756|Methanomicrobia	N	type II secretion system protein	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DTH2_k127_6369834_1	679926.Mpet_2069	0.000393	48.0	arCOG08229@1|root,arCOG08229@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Reg_prop
DTH2_k127_6381367_0	679926.Mpet_1273	1.57e-131	424.0	COG0069@1|root,arCOG00619@2157|Archaea,2XU89@28890|Euryarchaeota,2NA9H@224756|Methanomicrobia	224756|Methanomicrobia	E	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
DTH2_k127_6381367_4	593750.Metfor_1533	1.686e-11	71.0	arCOG07676@1|root,arCOG07676@2157|Archaea	2157|Archaea	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6381367_3	351160.RCIX696	1.107e-52	203.0	arCOG06399@1|root,arCOG06399@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans4,PMT_2
DTH2_k127_6381367_2	368407.Memar_2026	7.434e-77	265.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,2N96I@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM bifunctional deaminase-reductase domain protein	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
DTH2_k127_6381367_1	756067.MicvaDRAFT_1602	3.924e-77	274.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
DTH2_k127_6399248_2	368407.Memar_2364	2.543e-106	353.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,2N925@224756|Methanomicrobia	224756|Methanomicrobia	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
DTH2_k127_6399248_0	368407.Memar_2365	7.85e-172	548.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,2N9EZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the HMG-CoA reductase family	hmgA-2	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1972	HMG-CoA_red
DTH2_k127_6399248_3	456442.Mboo_0136	4.068e-48	177.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2NA25@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
DTH2_k127_6399248_1	593750.Metfor_0030	2.071e-121	403.0	COG4198@1|root,arCOG03573@2157|Archaea,2XZJQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
DTH2_k127_6399248_4	456442.Mboo_0134	2.081e-09	59.0	COG0040@1|root,arCOG02208@2157|Archaea,2Y2ZH@28890|Euryarchaeota,2NA8F@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
DTH2_k127_6408765_0	593750.Metfor_2516	1.524e-202	634.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,2NB7I@224756|Methanomicrobia	224756|Methanomicrobia	D	Involved in cell shape control	cetZ	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
DTH2_k127_6408765_1	368407.Memar_0725	3.445e-157	506.0	COG1232@1|root,arCOG01522@2157|Archaea,2XVES@28890|Euryarchaeota,2NAMB@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
DTH2_k127_6408765_2	368407.Memar_0724	3.532e-96	326.0	COG0392@1|root,arCOG00897@2157|Archaea,2XT65@28890|Euryarchaeota,2NA8D@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	Glycos_transf_2,LPG_synthase_TM
DTH2_k127_6408765_3	694440.JOMF01000007_gene842	7.665e-83	288.0	COG0392@1|root,arCOG00897@2157|Archaea,2XT65@28890|Euryarchaeota,2NBAD@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
DTH2_k127_6408765_4	593750.Metfor_2520	9.12e-72	249.0	COG5427@1|root,arCOG00563@2157|Archaea,2XV1K@28890|Euryarchaeota,2NAMT@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
DTH2_k127_6410753_0	456442.Mboo_1875	6.369e-166	539.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
DTH2_k127_6410753_1	368407.Memar_1963	6.019e-63	220.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
DTH2_k127_6410786_2	368407.Memar_1963	2.911e-62	218.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
DTH2_k127_6410786_0	456442.Mboo_1875	1.933e-164	535.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
DTH2_k127_6410786_3	368407.Memar_1961	8.872e-45	166.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,2N9X1@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
DTH2_k127_6410786_4	521011.Mpal_0548	2.483e-40	152.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
DTH2_k127_6410786_1	456442.Mboo_1872	3.744e-82	281.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,2N9MM@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
DTH2_k127_6410786_5	368407.Memar_1958	3.821e-19	98.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
DTH2_k127_6413735_2	593750.Metfor_1349	1.393e-13	70.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,2N9EW@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM TatD-related deoxyribonuclease	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
DTH2_k127_6413735_1	521011.Mpal_1889	5.924e-36	143.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,2N9TR@224756|Methanomicrobia	224756|Methanomicrobia	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
DTH2_k127_6413735_0	456442.Mboo_1673	6.553e-218	683.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,2N9E6@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
DTH2_k127_6417917_0	368407.Memar_1576	1.474e-85	287.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,2N9M4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
DTH2_k127_6417917_1	368407.Memar_1575	1.65e-42	166.0	arCOG04389@1|root,arCOG04389@2157|Archaea,2XWXD@28890|Euryarchaeota	28890|Euryarchaeota	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6417917_2	410358.Mlab_0532	7.822e-06	48.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
DTH2_k127_6425132_0	593750.Metfor_2257	1.752e-99	345.0	COG0491@1|root,arCOG00504@2157|Archaea	2157|Archaea	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH2_k127_6425132_2	370438.PTH_2272	1.063e-15	83.0	COG1366@1|root,COG1366@2|Bacteria,1VB77@1239|Firmicutes,25I7G@186801|Clostridia,266C7@186807|Peptococcaceae	186801|Clostridia	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
DTH2_k127_6425132_1	593750.Metfor_2255	1.173e-40	155.0	COG2208@1|root,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota	28890|Euryarchaeota	T	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,SpoIIE
DTH2_k127_6438232_2	694440.JOMF01000004_gene1118	7.469e-11	64.0	arCOG05290@1|root,arCOG05290@2157|Archaea,2Y58D@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6438232_0	368407.Memar_0063	1.956e-84	297.0	COG1361@1|root,arCOG04400@2157|Archaea,2XZN3@28890|Euryarchaeota,2N9X5@224756|Methanomicrobia	224756|Methanomicrobia	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
DTH2_k127_6438232_1	368407.Memar_0490	7.679e-15	76.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota,2N9CB@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	pdhD	-	1.8.1.4,1.8.1.7	ko:K00382,ko:K00383	ko00010,ko00020,ko00260,ko00280,ko00480,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04918,map00010,map00020,map00260,map00280,map00480,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04918	M00009,M00011,M00036,M00307,M00532	R00094,R00115,R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00011,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
DTH2_k127_6443509_0	368407.Memar_2430	2.274e-296	924.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	2157|Archaea	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6465963_1	679926.Mpet_0542	4.435e-90	306.0	COG4198@1|root,arCOG03573@2157|Archaea,2XZJQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterised conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
DTH2_k127_6465963_0	456442.Mboo_0134	1.331e-144	463.0	COG0040@1|root,arCOG02208@2157|Archaea,2Y2ZH@28890|Euryarchaeota,2NA8F@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
DTH2_k127_6503891_2	593750.Metfor_2034	1.083e-53	191.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,2NA23@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
DTH2_k127_6503891_1	368407.Memar_2408	2.155e-57	212.0	COG1575@1|root,arCOG00480@2157|Archaea,2XXM6@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
DTH2_k127_6503891_0	368407.Memar_0116	9.075e-205	648.0	COG1233@1|root,arCOG01521@2157|Archaea,2XSVN@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG1233 Phytoene dehydrogenase and related proteins	crtI1	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,1.3.99.37	ko:K10027,ko:K20611	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
DTH2_k127_6527327_2	323259.Mhun_1807	4.815e-14	72.0	COG1633@1|root,arCOG01102@2157|Archaea	2157|Archaea	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH2_k127_6527327_0	456442.Mboo_0725	2.409e-68	242.0	arCOG03165@1|root,arCOG03165@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6527327_1	593750.Metfor_1687	2.926e-64	229.0	COG0642@1|root,arCOG06193@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
DTH2_k127_6562625_1	368407.Memar_0456	2.142e-83	282.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,2N99B@224756|Methanomicrobia	224756|Methanomicrobia	S	hydrophobe amphiphile efflux-3 (HAE3) family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
DTH2_k127_6562625_0	368407.Memar_1926	3.18e-93	311.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,2N9EE@224756|Methanomicrobia	224756|Methanomicrobia	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
DTH2_k127_6584285_3	368407.Memar_0417	2.701e-33	131.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,2N9FC@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM NiFe hydrogenase maturation protein HypF	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
DTH2_k127_6584285_1	368407.Memar_0418	7.125e-69	237.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,2N9RU@224756|Methanomicrobia	224756|Methanomicrobia	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
DTH2_k127_6584285_0	368407.Memar_0419	4.714e-122	396.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,2N9I6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein, Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
DTH2_k127_6584285_2	521011.Mpal_0184	6.776e-37	154.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,2N92E@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
DTH2_k127_6585944_0	456442.Mboo_0492	2.155e-127	413.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,2N9QE@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the LDH MDH superfamily	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
DTH2_k127_6585944_1	593750.Metfor_2699	2.464e-116	384.0	arCOG01220@1|root,arCOG01220@2157|Archaea,2XYGI@28890|Euryarchaeota,2N9S5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
DTH2_k127_6639179_2	593750.Metfor_0211	2.806e-125	412.0	COG1924@1|root,arCOG02679@2157|Archaea,2XU50@28890|Euryarchaeota,2N92J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
DTH2_k127_6639179_3	368407.Memar_2062	3.923e-69	237.0	COG4050@1|root,arCOG04903@2157|Archaea,2XY68@28890|Euryarchaeota,2N9PJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2112
DTH2_k127_6639179_5	368407.Memar_2063	3.005e-47	190.0	COG4029@1|root,arCOG04901@2157|Archaea,2XZQS@28890|Euryarchaeota,2N9W1@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2102)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2102
DTH2_k127_6639179_1	456442.Mboo_2435	4.55e-157	510.0	COG4070@1|root,arCOG04900@2157|Archaea,2XU32@28890|Euryarchaeota,2N90Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the UPF0288 family	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6639179_0	456442.Mboo_2434	6.237e-274	850.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
DTH2_k127_6639179_4	456442.Mboo_2433	7.936e-53	189.0	COG4087@1|root,arCOG01579@2157|Archaea,2XXV0@28890|Euryarchaeota,2N9NS@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iAF692.Mbar_A0708	Hydrolase
DTH2_k127_6643747_0	593750.Metfor_2897	2.187e-90	304.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,2N9NJ@224756|Methanomicrobia	224756|Methanomicrobia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A1332	PseudoU_synth_1
DTH2_k127_6643747_1	368407.Memar_2222	9.223e-80	280.0	arCOG03450@1|root,arCOG03450@2157|Archaea,2XV0N@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6643747_2	593750.Metfor_1470	9.111e-39	151.0	arCOG08232@1|root,arCOG08232@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6655183_1	679926.Mpet_1736	2.668e-124	410.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,2N93R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB2	-	2.7.7.6	ko:K03044	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
DTH2_k127_6655183_0	368407.Memar_0312	6.566e-237	734.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU9Q@28890|Euryarchaeota,2N99Y@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the RNA polymerase beta chain family	rpoB1	-	2.7.7.6	ko:K03045	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3
DTH2_k127_6753126_1	368407.Memar_0046	4.844e-34	133.0	COG0681@1|root,arCOG01739@2157|Archaea,2XU45@28890|Euryarchaeota,2N9SB@224756|Methanomicrobia	224756|Methanomicrobia	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DTH2_k127_6753126_0	521011.Mpal_0409	1.811e-190	604.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
DTH2_k127_6765558_3	456442.Mboo_1897	1.177e-12	72.0	arCOG05309@1|root,arCOG05309@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6765558_1	368407.Memar_1984	1.133e-23	105.0	COG0526@1|root,arCOG01972@2157|Archaea	2157|Archaea	O	Thioredoxin	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	DUF836,Thioredoxin,Thioredoxin_3
DTH2_k127_6765558_0	368407.Memar_1983	1.795e-61	217.0	COG1326@1|root,arCOG02680@2157|Archaea,2XUFW@28890|Euryarchaeota,2NA07@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal Zn-finger protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6765558_2	593750.Metfor_1080	2.722e-22	103.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,2NB77@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
DTH2_k127_6803259_6	679926.Mpet_2203	4.427e-25	108.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2N9Q6@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
DTH2_k127_6803259_7	521011.Mpal_0456	2.592e-23	100.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y04R@28890|Euryarchaeota,2NA3T@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
DTH2_k127_6803259_2	368407.Memar_0577	3.712e-65	226.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,2N9KJ@224756|Methanomicrobia	224756|Methanomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
DTH2_k127_6803259_0	593750.Metfor_2643	3.172e-92	313.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,2N9HR@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,RS4NT,Ribosomal_S4e,S4
DTH2_k127_6803259_4	368407.Memar_0575	3.242e-39	149.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2N9XR@224756|Methanomicrobia	224756|Methanomicrobia	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
DTH2_k127_6803259_1	521011.Mpal_0452	1.273e-67	233.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,2N9SH@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
DTH2_k127_6803259_3	323259.Mhun_2244	2.319e-49	182.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
DTH2_k127_6803259_5	593750.Metfor_2647	1.73e-25	110.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,2NA4I@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
DTH2_k127_6803259_8	593750.Metfor_2648	5.135e-23	99.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,2NA4R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
DTH2_k127_6805531_3	679926.Mpet_1811	5.258e-28	118.0	COG1935@1|root,arCOG04420@2157|Archaea,2Y1FM@28890|Euryarchaeota,2NA37@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF473)	-	-	-	ko:K09135	-	-	-	-	ko00000	-	-	-	DUF473
DTH2_k127_6805531_0	368407.Memar_2010	5.072e-108	353.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
DTH2_k127_6805531_2	368407.Memar_2009	1.434e-30	123.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y1TD@28890|Euryarchaeota,2NBJH@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_6805531_1	368407.Memar_2008	2.383e-62	220.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
DTH2_k127_6811700_0	521011.Mpal_0745	8.664e-142	454.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,2N90U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DTH2_k127_6811700_1	593750.Metfor_0529	1.522e-108	358.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,2N9EP@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
DTH2_k127_6811700_2	368407.Memar_1835	4.962e-13	72.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y879@28890|Euryarchaeota,2N9M1@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
DTH2_k127_6901027_2	1220534.B655_2239	2.464e-73	251.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type tungstate transport system, periplasmic component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
DTH2_k127_6901027_0	593750.Metfor_0675	4.214e-106	355.0	COG3585@1|root,COG3839@1|root,arCOG00175@2157|Archaea,arCOG00228@2157|Archaea,2Y7NF@28890|Euryarchaeota,2N9QM@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE
DTH2_k127_6901027_1	368407.Memar_1895	8.454e-83	283.0	COG1576@1|root,arCOG00502@2157|Archaea,2XZ8Z@28890|Euryarchaeota	28890|Euryarchaeota	J	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DTH2_k127_6901027_3	368407.Memar_1865	4.18e-31	123.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,2N968@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
DTH2_k127_6979156_3	368407.Memar_0408	1.827e-103	346.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,2N9S6@224756|Methanomicrobia	224756|Methanomicrobia	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
DTH2_k127_6979156_0	593750.Metfor_0401	9.443e-183	580.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,2N926@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin,tRNA_deacylase
DTH2_k127_6979156_8	368407.Memar_0410	5.826e-21	93.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y188@28890|Euryarchaeota,2NA63@224756|Methanomicrobia	224756|Methanomicrobia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
DTH2_k127_6979156_6	593750.Metfor_0403	6.534e-70	241.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2N9MV@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
DTH2_k127_6979156_5	694440.JOMF01000007_gene860	3.64e-72	248.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,2N9QF@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
DTH2_k127_6979156_4	593750.Metfor_0416	1.701e-93	311.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,2N9HV@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DTH2_k127_6979156_2	368407.Memar_0414	5.951e-113	370.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,2N993@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
DTH2_k127_6979156_7	456442.Mboo_2249	9.527e-31	123.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2N9U8@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
DTH2_k127_6979156_1	323259.Mhun_2216	3.631e-115	379.0	COG0477@1|root,arCOG00143@2157|Archaea,2XUTR@28890|Euryarchaeota,2N94Q@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DTH2_k127_6980391_0	521011.Mpal_2578	2.004e-89	301.0	COG0391@1|root,arCOG04395@2157|Archaea,2XTPP@28890|Euryarchaeota,2N94E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
DTH2_k127_6980391_2	269797.Mbar_A0933	1.713e-25	116.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7RH@28890|Euryarchaeota	28890|Euryarchaeota	T	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
DTH2_k127_6980391_1	339670.Bamb_1962	4.013e-26	119.0	COG1413@1|root,COG1413@2|Bacteria,1R4SF@1224|Proteobacteria,2VNIJ@28216|Betaproteobacteria,1K4RB@119060|Burkholderiaceae	28216|Betaproteobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
DTH2_k127_7057926_0	368408.Tpen_1254	1.528e-89	303.0	COG1180@1|root,arCOG00936@2157|Archaea,2XQ3S@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DTH2_k127_7057926_2	592015.HMPREF1705_02026	1.798e-61	226.0	COG0778@1|root,COG0778@2|Bacteria,3TCD8@508458|Synergistetes	508458|Synergistetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DTH2_k127_7057926_1	593750.Metfor_2562	7.028e-84	290.0	COG1234@1|root,arCOG00500@2157|Archaea	2157|Archaea	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
DTH2_k127_7057926_3	1206732.BAGD01000084_gene3623	2.329e-09	60.0	COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria,4G0QP@85025|Nocardiaceae	201174|Actinobacteria	S	Appr-1'-p processing enzyme	lppD	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Macro
DTH2_k127_7065326_0	330214.NIDE3745	4.965e-144	473.0	COG0474@1|root,COG0474@2|Bacteria,3J0YX@40117|Nitrospirae	40117|Nitrospirae	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
DTH2_k127_7215912_0	368407.Memar_0936	4.547e-127	417.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,2N97T@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
DTH2_k127_7215912_2	368407.Memar_0938	4.822e-24	108.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y17T@28890|Euryarchaeota,2NA3Y@224756|Methanomicrobia	224756|Methanomicrobia	S	RNase L inhibitor, RLI	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7215912_1	456442.Mboo_1332	5.622e-47	170.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,2N9CQ@224756|Methanomicrobia	224756|Methanomicrobia	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
DTH2_k127_735876_3	593750.Metfor_2305	2.097e-54	199.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota,2NBBC@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase zinc-dependent	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
DTH2_k127_735876_4	593750.Metfor_2306	2.79e-44	173.0	COG1255@1|root,arCOG04385@2157|Archaea,2XYWU@28890|Euryarchaeota,2NBE6@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0146 family	-	-	-	ko:K09713	-	-	-	-	ko00000	-	-	-	UPF0146
DTH2_k127_735876_1	368407.Memar_0831	3.799e-146	475.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,2N94D@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
DTH2_k127_735876_0	593750.Metfor_2308	1.818e-150	482.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
DTH2_k127_735876_2	368407.Memar_0833	6.847e-83	282.0	COG4002@1|root,arCOG00854@2157|Archaea,2XXS9@28890|Euryarchaeota,2N9HQ@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogen marker protein 4	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_735876_5	521011.Mpal_1748	9.839e-28	112.0	COG2036@1|root,arCOG02144@2157|Archaea	2157|Archaea	K	transcription factor (CBF NF-Y)	hstA	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
DTH2_k127_7598216_2	456442.Mboo_0088	5.965e-48	175.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,2N9C4@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DTH2_k127_7598216_0	521011.Mpal_0401	6.115e-193	612.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,2N91C@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
DTH2_k127_7598216_1	456442.Mboo_0086	4.119e-122	396.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinate dehydrogenase fumarate reductase flavoprotein subunit	sdhA	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114	1.3.4.1,1.3.5.1,1.3.5.4	ko:K00239,ko:K18209	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376,M00620	R02164,R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
DTH2_k127_7624183_3	1123302.KB904187_gene872	2.534e-12	68.0	COG2189@1|root,COG2189@2|Bacteria,1UHUQ@1239|Firmicutes,4HCEV@91061|Bacilli	91061|Bacilli	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DTH2_k127_7624183_1	1304880.JAGB01000002_gene1553	1.622e-91	312.0	COG1814@1|root,COG1814@2|Bacteria,1UZVX@1239|Firmicutes,24BSJ@186801|Clostridia	186801|Clostridia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
DTH2_k127_7624183_0	368407.Memar_2326	2.291e-161	521.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
DTH2_k127_7624183_2	368407.Memar_1303	2.32e-12	67.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N93C@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	-	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
DTH2_k127_7647532_2	456442.Mboo_1462	3.267e-07	55.0	COG1813@1|root,arCOG01863@2157|Archaea,2XYZ0@28890|Euryarchaeota,2N9WA@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
DTH2_k127_7647532_0	368407.Memar_1305	9.806e-201	634.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N92K@224756|Methanomicrobia	224756|Methanomicrobia	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
DTH2_k127_7647532_1	368407.Memar_1080	7.846e-11	64.0	COG0225@1|root,arCOG02816@2157|Archaea,2XWKA@28890|Euryarchaeota,2N9M6@224756|Methanomicrobia	224756|Methanomicrobia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
DTH2_k127_7680555_0	368407.Memar_1296	8.057e-150	480.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,2N90S@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
DTH2_k127_7680555_1	368407.Memar_1688	3.886e-22	96.0	arCOG06880@1|root,arCOG06880@2157|Archaea	2157|Archaea	-	-	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DTH2_k127_7680555_2	456442.Mboo_1973	6.968e-08	57.0	arCOG09605@1|root,arCOG09605@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7681852_0	368407.Memar_0380	2.562e-115	382.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
DTH2_k127_7681852_1	593750.Metfor_2398	3.473e-106	368.0	COG0642@1|root,arCOG02348@1|root,arCOG02385@1|root,arCOG02348@2157|Archaea,arCOG02385@2157|Archaea,arCOG06193@2157|Archaea,arCOG06219@2157|Archaea,2Y7TZ@28890|Euryarchaeota,2NAUN@224756|Methanomicrobia	2157|Archaea	T	PFAM response regulator receiver	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA_7TM,PAS,PAS_4,PAS_8,PAS_9,Response_reg
DTH2_k127_7693306_0	368407.Memar_1577	4.205e-97	323.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,2N94X@224756|Methanomicrobia	224756|Methanomicrobia	J	TGS domain protein	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
DTH2_k127_7693306_1	456442.Mboo_1726	9.729e-41	155.0	arCOG05310@1|root,arCOG05310@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7693306_2	456442.Mboo_1727	3.535e-08	57.0	arCOG07830@1|root,arCOG07830@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_7701312_2	679926.Mpet_0278	1.301e-10	61.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,2N98M@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
DTH2_k127_7701312_0	593750.Metfor_1251	5.102e-140	453.0	COG1162@1|root,arCOG00351@2157|Archaea,2XV42@28890|Euryarchaeota,2N9C0@224756|Methanomicrobia	224756|Methanomicrobia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
DTH2_k127_7701312_1	1340434.AXVA01000018_gene866	1.312e-23	104.0	COG2350@1|root,COG2350@2|Bacteria,1VJXT@1239|Firmicutes,4HR02@91061|Bacilli	91061|Bacilli	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
DTH2_k127_7707825_2	368407.Memar_0274	4.378e-08	56.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2N9B3@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
DTH2_k127_7707825_1	593750.Metfor_0293	4.438e-90	304.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,2N92A@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
DTH2_k127_7707825_0	368407.Memar_0276	9.549e-132	424.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
DTH2_k127_7724318_0	521011.Mpal_1524	5.202e-104	347.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
DTH2_k127_7724318_1	632335.Calkr_0531	9.429e-60	208.0	COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia,42J79@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ferredoxin-dependent glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
DTH2_k127_7732842_2	593750.Metfor_1609	6.682e-60	213.0	arCOG03443@1|root,arCOG03443@2157|Archaea,2XYM1@28890|Euryarchaeota	28890|Euryarchaeota	S	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RLAN
DTH2_k127_7732842_0	267377.MMP0436	5.061e-112	379.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT55@28890|Euryarchaeota,23RH7@183939|Methanococci	183939|Methanococci	H	RimK domain protein ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	RimK
DTH2_k127_7732842_1	593750.Metfor_1255	1.999e-96	331.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
DTH2_k127_7825344_1	521011.Mpal_0437	6.808e-60	210.0	COG0195@1|root,arCOG01760@2157|Archaea	2157|Archaea	K	transcription termination protein NusA	nusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
DTH2_k127_7825344_3	593750.Metfor_0781	8.311e-24	109.0	COG0140@1|root,arCOG02677@2157|Archaea,2XYNB@28890|Euryarchaeota,2NA17@224756|Methanomicrobia	224756|Methanomicrobia	E	phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
DTH2_k127_7825344_2	368407.Memar_1780	4.896e-47	175.0	COG1259@1|root,arCOG01759@2157|Archaea,2XWIM@28890|Euryarchaeota,2NA0M@224756|Methanomicrobia	224756|Methanomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
DTH2_k127_7825344_0	679926.Mpet_0732	4.529e-112	372.0	COG0392@1|root,arCOG00899@2157|Archaea,2XY3K@28890|Euryarchaeota,2NATI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
DTH2_k127_7828153_0	521011.Mpal_1185	7.068e-81	278.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
DTH2_k127_7828153_3	368407.Memar_0500	8.915e-12	74.0	COG1681@1|root,arCOG01829@2157|Archaea	2157|Archaea	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07324,ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
DTH2_k127_7828153_1	234267.Acid_5754	6.983e-37	142.0	COG3324@1|root,COG3324@2|Bacteria,3Y8A9@57723|Acidobacteria	57723|Acidobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
DTH2_k127_7828153_2	456442.Mboo_0114	3.061e-28	117.0	COG3548@1|root,arCOG04887@2157|Archaea,2XUMU@28890|Euryarchaeota	28890|Euryarchaeota	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
DTH2_k127_7845738_0	521011.Mpal_2338	1.436e-112	372.0	COG0483@1|root,arCOG01349@2157|Archaea,2XUBB@28890|Euryarchaeota,2N9NZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
DTH2_k127_7845738_1	368407.Memar_0966	5.979e-54	192.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,2N9R5@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
DTH2_k127_7845738_2	368407.Memar_0964	1.026e-29	128.0	arCOG06912@1|root,arCOG06912@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_784784_3	593750.Metfor_2460	5.032e-41	156.0	COG0314@1|root,arCOG00534@2157|Archaea,2XZG1@28890|Euryarchaeota	28890|Euryarchaeota	H	Molybdopterin converting factor	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
DTH2_k127_784784_4	593750.Metfor_0808	8.282e-33	129.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DTH2_k127_784784_1	593750.Metfor_2458	3.79e-111	364.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1238	ThiF
DTH2_k127_784784_5	521011.Mpal_1213	2.33e-32	133.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y0ZB@28890|Euryarchaeota,2N9ZS@224756|Methanomicrobia	224756|Methanomicrobia	S	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	-
DTH2_k127_784784_2	593750.Metfor_2454	5.09e-90	315.0	COG1606@1|root,arCOG00043@2157|Archaea,2XV2X@28890|Euryarchaeota,2N9N2@224756|Methanomicrobia	224756|Methanomicrobia	S	PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase,QueC
DTH2_k127_784784_0	521011.Mpal_1941	1.753e-118	391.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2N94V@224756|Methanomicrobia	224756|Methanomicrobia	E	DegT/DnrJ/EryC1/StrS aminotransferase family	nifS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
DTH2_k127_7889854_0	593750.Metfor_2631	1.343e-77	263.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota	28890|Euryarchaeota	F	Belongs to the archaeal adenylate kinase family	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
DTH2_k127_7889854_2	456442.Mboo_0603	6.585e-16	82.0	arCOG01744@1|root,arCOG01744@2157|Archaea	2157|Archaea	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
DTH2_k127_7889854_1	679926.Mpet_2737	2.309e-26	118.0	COG2881@1|root,arCOG03630@2157|Archaea	2157|Archaea	S	PFAM Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
DTH2_k127_7899903_0	368407.Memar_1684	1.298e-188	598.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
DTH2_k127_7899903_2	70601.3257532	3.384e-34	139.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,242PR@183968|Thermococci	183968|Thermococci	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C1,TGT_C2
DTH2_k127_7899903_1	521011.Mpal_2534	1.436e-35	138.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,2NA0G@224756|Methanomicrobia	224756|Methanomicrobia	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
DTH2_k127_7899903_3	456442.Mboo_1831	1.611e-30	128.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,2N9MR@224756|Methanomicrobia	224756|Methanomicrobia	Q	PFAM tRNA methyltransferase complex GCD14 subunit	pimT	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,Methyltransf_31,PCMT
DTH2_k127_7922173_4	593750.Metfor_2520	3.612e-32	131.0	COG5427@1|root,arCOG00563@2157|Archaea,2XV1K@28890|Euryarchaeota,2NAMT@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
DTH2_k127_7922173_2	593750.Metfor_2521	1.333e-55	196.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2N9WX@224756|Methanomicrobia	224756|Methanomicrobia	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
DTH2_k127_7922173_3	593750.Metfor_2522	2.735e-33	128.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,2N9ZH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
DTH2_k127_7922173_5	694440.JOMF01000007_gene846	1.374e-29	120.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,2NA03@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
DTH2_k127_7922173_1	368407.Memar_0718	1.029e-62	218.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2N9MF@224756|Methanomicrobia	224756|Methanomicrobia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iAF692.Mbar_A3385	NDK
DTH2_k127_7922173_0	368407.Memar_0715	1.281e-72	254.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,2NA3A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DTH2_k127_7922173_6	521011.Mpal_1560	1.596e-18	89.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2N96D@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC-1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH2_k127_8002183_0	368407.Memar_0860	1.414e-148	494.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
DTH2_k127_8002183_1	456442.Mboo_1658	1.351e-113	374.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,2N9AW@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15,2.7.1.213,2.7.1.73	ko:K00852,ko:K22026	ko00030,ko00230,ko00240,map00030,map00230,map00240	-	R00513,R01051,R01131,R01228,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2903	PfkB
DTH2_k127_8002183_3	456442.Mboo_1659	2.454e-49	177.0	COG1885@1|root,arCOG02119@2157|Archaea,2XX3M@28890|Euryarchaeota,2N9T5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0212 family	-	-	-	ko:K09731	-	-	-	-	ko00000	-	-	-	DUF555
DTH2_k127_8002183_2	593750.Metfor_2413	1.899e-70	244.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota,2NAXX@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DTH2_k127_8002183_4	410358.Mlab_0579	1.062e-23	103.0	arCOG04481@1|root,arCOG04481@2157|Archaea,2Y0HE@28890|Euryarchaeota,2NA4C@224756|Methanomicrobia	224756|Methanomicrobia	S	Family of unknown function (DUF5350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5350
DTH2_k127_8023581_0	1192034.CAP_1258	1.02e-49	181.0	COG1208@1|root,COG1208@2|Bacteria,1R2NS@1224|Proteobacteria	1224|Proteobacteria	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
DTH2_k127_8023581_2	1047013.AQSP01000138_gene1042	2.137e-41	165.0	COG1089@1|root,COG1089@2|Bacteria,2NP6U@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	wcbK	-	1.1.1.281,4.2.1.47	ko:K01711,ko:K15856	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888,R03397,R03399	RC00182,RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
DTH2_k127_8023581_1	456442.Mboo_1736	8.315e-47	169.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,2N9CW@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
DTH2_k127_80638_2	456442.Mboo_0882	5.986e-21	93.0	COG0717@1|root,arCOG04048@2157|Archaea,2XTSH@28890|Euryarchaeota	28890|Euryarchaeota	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13,3.5.4.30	ko:K01494,ko:K09887	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325,R07307	RC00074,RC01825	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
DTH2_k127_80638_0	456442.Mboo_0861	5.638e-99	329.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,2N9I5@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
DTH2_k127_80638_1	323259.Mhun_1010	2.844e-89	298.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
DTH2_k127_8072978_1	368407.Memar_0397	1.208e-171	546.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,2N951@224756|Methanomicrobia	224756|Methanomicrobia	S	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
DTH2_k127_8072978_2	593750.Metfor_0388	3.249e-66	232.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,2N9JZ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
DTH2_k127_8072978_0	410358.Mlab_0756	7.92e-190	602.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH2_k127_8094278_2	368407.Memar_0510	1.544e-26	109.0	COG2875@1|root,arCOG00645@2157|Archaea,2XSZA@28890|Euryarchaeota,2N9G2@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0627	TP_methylase
DTH2_k127_8094278_0	368407.Memar_0511	3.317e-101	340.0	COG2073@1|root,arCOG00651@2157|Archaea,2XTVD@28890|Euryarchaeota,2N9TZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM cobalamin (vitamin B12) biosynthesis CbiG protein	-	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N
DTH2_k127_8094278_1	593750.Metfor_1475	2.7e-98	327.0	COG1010@1|root,arCOG00647@2157|Archaea,2XT45@28890|Euryarchaeota,2N9B8@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.131	ko:K05934	ko00860,ko01100,map00860,map01100	-	R05180,R05809	RC00003,RC01293,RC03471	ko00000,ko00001,ko01000	-	-	-	TP_methylase
DTH2_k127_8094278_3	269797.Mbar_A0630	5.943e-19	91.0	COG2082@1|root,arCOG02247@2157|Archaea,2XT0S@28890|Euryarchaeota,2N9MJ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Precorrin-8X methylmutase CbiC CobH	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0630	CbiC
DTH2_k127_8105514_0	868131.MSWAN_0024	5.775e-53	204.0	COG2710@1|root,arCOG00591@2157|Archaea,2XXZF@28890|Euryarchaeota	28890|Euryarchaeota	C	Nitrogenase component 1 type Oxidoreductase	-	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
DTH2_k127_8167571_1	593750.Metfor_1512	6.243e-86	289.0	COG2874@1|root,arCOG04148@2157|Archaea,2XUMD@28890|Euryarchaeota,2N9IB@224756|Methanomicrobia	224756|Methanomicrobia	N	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
DTH2_k127_8167571_0	368407.Memar_0949	1.595e-285	887.0	COG4962@1|root,arCOG01817@2157|Archaea,2XTDM@28890|Euryarchaeota,2N9CE@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DTH2_k127_8181184_3	616991.JPOO01000001_gene2930	7.414e-31	128.0	COG4315@1|root,COG4315@2|Bacteria,4NI3N@976|Bacteroidetes,1HYWK@117743|Flavobacteriia	976|Bacteroidetes	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
DTH2_k127_8181184_2	679926.Mpet_0317	8.114e-40	156.0	COG2426@1|root,arCOG01330@2157|Archaea,2Y4KG@28890|Euryarchaeota	28890|Euryarchaeota	S	Small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
DTH2_k127_8181184_1	368407.Memar_1314	7.408e-138	451.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,2N962@224756|Methanomicrobia	224756|Methanomicrobia	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
DTH2_k127_8181184_0	521011.Mpal_1009	2.073e-195	615.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DTH2_k127_8221898_0	521011.Mpal_0675	1.452e-155	512.0	COG2133@1|root,arCOG03441@1|root,arCOG02796@2157|Archaea,arCOG03441@2157|Archaea,2XT1Q@28890|Euryarchaeota	28890|Euryarchaeota	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,GSDH
DTH2_k127_8221898_1	368407.Memar_0067	7.2e-14	78.0	arCOG03505@1|root,arCOG03505@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2953)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2953
DTH2_k127_8277827_1	883.DvMF_1526	7.798e-24	107.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42QCN@68525|delta/epsilon subdivisions,2X5R7@28221|Deltaproteobacteria,2MGUN@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DTH2_k127_8277827_0	593750.Metfor_0948	1.573e-186	594.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9W@28890|Euryarchaeota,2NAP6@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
DTH2_k127_8290254_2	368407.Memar_2141	5.09e-103	345.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
DTH2_k127_8290254_4	323259.Mhun_2439	8.343e-56	208.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,2N9MQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
DTH2_k127_8290254_0	456442.Mboo_0122	7.561e-181	574.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,2N95C@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
DTH2_k127_8290254_1	456442.Mboo_0123	1.906e-159	511.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,2N98R@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
DTH2_k127_8290254_5	521011.Mpal_0513	1.11e-51	192.0	COG2430@1|root,arCOG01766@2157|Archaea,2XY9F@28890|Euryarchaeota,2N9PD@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF432)	-	-	-	ko:K09149	-	-	-	-	ko00000	-	-	-	DUF432
DTH2_k127_8290254_3	224325.AF_1546	6.996e-67	237.0	COG0668@1|root,arCOG01568@2157|Archaea,2XUHN@28890|Euryarchaeota,245QV@183980|Archaeoglobi	183980|Archaeoglobi	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
DTH2_k127_8290254_6	368407.Memar_2128	1.684e-13	73.0	arCOG07476@1|root,arCOG07476@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
DTH2_k127_8387760_1	593750.Metfor_0591	7.164e-58	211.0	COG2314@1|root,COG5635@1|root,arCOG02967@2157|Archaea,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
DTH2_k127_8387760_0	593750.Metfor_0591	2.708e-81	281.0	COG2314@1|root,COG5635@1|root,arCOG02967@2157|Archaea,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
DTH2_k127_8387760_2	456442.Mboo_1254	1.91e-34	141.0	arCOG07763@1|root,arCOG07763@2157|Archaea	2157|Archaea	L	DNA polymerase activity	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	-
DTH2_k127_8387760_4	456442.Mboo_0433	5.262e-12	75.0	arCOG07300@1|root,arCOG07300@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8387760_3	521011.Mpal_1185	9.89e-19	92.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
DTH2_k127_8469605_1	593750.Metfor_2097	2.34e-119	389.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,2N915@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
DTH2_k127_8469605_4	593750.Metfor_2096	6.261e-13	70.0	arCOG06113@1|root,arCOG06113@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K06193	ko01120,map01120	-	-	-	ko00000	-	-	-	TF_Zn_Ribbon
DTH2_k127_8469605_2	521011.Mpal_1964	1.005e-78	276.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,2N9K9@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0788	AA_kinase
DTH2_k127_8469605_3	456442.Mboo_0761	8.462e-68	238.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,2N9S3@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
DTH2_k127_8469605_0	593750.Metfor_2077	3.146e-142	458.0	COG0306@1|root,arCOG02267@2157|Archaea,2XSUU@28890|Euryarchaeota,2N9TT@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM phosphate transporter	pitA	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
DTH2_k127_8501268_0	368407.Memar_0157	2.424e-87	312.0	COG0642@1|root,COG3413@1|root,arCOG02336@1|root,arCOG06516@1|root,arCOG06712@1|root,arCOG02276@2157|Archaea,arCOG02336@2157|Archaea,arCOG02351@2157|Archaea,arCOG06516@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
DTH2_k127_8535230_3	368407.Memar_1300	1.592e-59	211.0	COG0722@1|root,arCOG00245@2157|Archaea,2XU8C@28890|Euryarchaeota,2N9HG@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
DTH2_k127_8535230_1	368407.Memar_1301	6.362e-134	441.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
DTH2_k127_8535230_2	456442.Mboo_1558	2.304e-129	417.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K11645,ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568,R08568	RC00438,RC00439,RC00603,RC00604,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
DTH2_k127_8535230_0	593750.Metfor_1589	6.505e-135	433.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N93C@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	-	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
DTH2_k127_8862224_0	290315.Clim_1318	1.138e-114	379.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Trypsin,Trypsin_2
DTH2_k127_8862224_1	593750.Metfor_1972	2.117e-54	198.0	COG0212@1|root,arCOG00474@2157|Archaea	2157|Archaea	H	5-formyltetrahydrofolate cycloligase	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
DTH2_k127_8869427_0	368407.Memar_0339	9.305e-164	531.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,2N9BJ@224756|Methanomicrobia	224756|Methanomicrobia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	aor-2	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH2_k127_8869427_1	323259.Mhun_3049	1.916e-150	485.0	COG0492@1|root,arCOG01297@2157|Archaea,2Y84N@28890|Euryarchaeota,2N9Q1@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB-1	-	1.8.1.9	ko:K00384,ko:K03387	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
DTH2_k127_8876642_6	234267.Acid_2249	1.032e-78	282.0	COG0451@1|root,COG0451@2|Bacteria,3Y397@57723|Acidobacteria	57723|Acidobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
DTH2_k127_8876642_7	696281.Desru_1967	1.745e-64	234.0	COG1208@1|root,COG1208@2|Bacteria,1TPII@1239|Firmicutes,249GT@186801|Clostridia,260FK@186807|Peptococcaceae	186801|Clostridia	JM	TIGRFAM Glucose-1-phosphate cytidylyltransferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
DTH2_k127_8876642_5	1437425.CSEC_0969	2.745e-113	375.0	COG0306@1|root,COG0306@2|Bacteria,2JH20@204428|Chlamydiae	204428|Chlamydiae	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
DTH2_k127_8876642_0	593750.Metfor_2114	1.578e-262	815.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
DTH2_k127_8876642_10	368407.Memar_0998	2.19e-23	102.0	arCOG03365@1|root,arCOG03365@2157|Archaea,2Y1W5@28890|Euryarchaeota,2NA3V@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8876642_3	368407.Memar_0999	7.251e-130	428.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,2N975@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the ATCase OTCase family	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DTH2_k127_8876642_2	368407.Memar_1000	8.949e-176	569.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
DTH2_k127_8876642_9	593750.Metfor_2118	6.64e-44	173.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,2N9UY@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
DTH2_k127_8876642_8	368407.Memar_1002	3.021e-54	197.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,2N9PZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
DTH2_k127_8876642_1	368407.Memar_1003	2.194e-236	739.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,2N91G@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
DTH2_k127_8876642_4	593750.Metfor_2122	1.266e-128	419.0	COG2423@1|root,arCOG01035@2157|Archaea,2XTTC@28890|Euryarchaeota,2N94J@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	ala	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
DTH2_k127_8876642_11	1116472.MGMO_1c00010	5.933e-17	92.0	COG0823@1|root,COG2815@1|root,COG3209@1|root,COG3291@1|root,COG0823@2|Bacteria,COG2815@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,1QXQ7@1224|Proteobacteria,1T3G4@1236|Gammaproteobacteria,1XGBG@135618|Methylococcales	135618|Methylococcales	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	REJ
DTH2_k127_8876734_3	593750.Metfor_1326	1.802e-32	127.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,2N90W@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
DTH2_k127_8876734_1	521011.Mpal_1017	6.91e-68	240.0	arCOG04998@1|root,arCOG04998@2157|Archaea,2XZR1@28890|Euryarchaeota,2N9VB@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8876734_2	593750.Metfor_1324	1.45e-57	203.0	COG4048@1|root,arCOG04902@2157|Archaea,2Y8FE@28890|Euryarchaeota,2N9Y6@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111
DTH2_k127_8876734_0	521011.Mpal_1015	1.424e-78	269.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,2N982@224756|Methanomicrobia	224756|Methanomicrobia	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
DTH2_k127_8916621_2	368407.Memar_1547	4.855e-29	124.0	arCOG06912@1|root,arCOG06912@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8916621_3	521011.Mpal_0973	4.187e-19	88.0	arCOG07469@1|root,arCOG07469@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8916621_1	593750.Metfor_1627	3.487e-37	142.0	arCOG02866@1|root,arCOG02866@2157|Archaea,2Y8JA@28890|Euryarchaeota,2NB6N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8916621_0	368407.Memar_1551	3.669e-136	437.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,2N92F@224756|Methanomicrobia	224756|Methanomicrobia	L	acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DnaJ_CXXCXGXG,S1,tRNA_anti-codon
DTH2_k127_8923123_0	368407.Memar_2354	4.036e-165	528.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTYM@28890|Euryarchaeota,2N9GI@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
DTH2_k127_8923123_1	368407.Memar_2355	4.694e-83	279.0	COG3390@1|root,arCOG02257@2157|Archaea,2XTM4@28890|Euryarchaeota,2N9JC@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
DTH2_k127_8941791_3	593750.Metfor_0133	2.917e-09	60.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,2NB15@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
DTH2_k127_8941791_1	456442.Mboo_0043	1.066e-70	244.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2N9QR@224756|Methanomicrobia	224756|Methanomicrobia	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH2_k127_8941791_0	521011.Mpal_0416	1.414e-184	596.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,2N91J@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine biosynthesis protein ThiC	thiC-1	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
DTH2_k127_8941791_2	593750.Metfor_0116	3.999e-50	182.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
DTH2_k127_8962972_0	368407.Memar_1468	1.657e-135	443.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota	28890|Euryarchaeota	M	involved in cell wall biogenesis	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
DTH2_k127_8962972_1	368407.Memar_1469	7.505e-42	160.0	arCOG00567@1|root,arCOG00567@2157|Archaea,2XVU1@28890|Euryarchaeota,2NA3X@224756|Methanomicrobia	224756|Methanomicrobia	M	glycosyl transferase, family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DTH2_k127_8970851_1	192952.MM_0383	4.066e-06	54.0	COG5658@1|root,arCOG04484@2157|Archaea,2XVWE@28890|Euryarchaeota,2NB7Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1648)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
DTH2_k127_8970851_0	368407.Memar_2193	5.917e-186	597.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,2N96P@224756|Methanomicrobia	224756|Methanomicrobia	E	Domain of unknown function (DUF3458_C) ARM repeats	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
DTH2_k127_8979728_2	593750.Metfor_1813	2.496e-05	49.0	arCOG09450@1|root,arCOG09450@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_8979728_0	368407.Memar_1462	2.043e-110	367.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
DTH2_k127_8979728_1	368407.Memar_1463	2.745e-110	361.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2N931@224756|Methanomicrobia	224756|Methanomicrobia	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
DTH2_k127_9028064_0	368407.Memar_2501	6.363e-157	503.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
DTH2_k127_9028064_3	593750.Metfor_0183	5.655e-68	235.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,2N9JJ@224756|Methanomicrobia	224756|Methanomicrobia	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
DTH2_k127_9028064_2	593750.Metfor_0184	2.425e-103	342.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
DTH2_k127_9028064_1	593750.Metfor_0185	4.054e-143	460.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,2N98T@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
DTH2_k127_9028159_1	456442.Mboo_1444	8.347e-74	253.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DTH2_k127_9028159_0	593750.Metfor_1684	8.061e-201	631.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,2N9B4@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DTH2_k127_9042332_1	456442.Mboo_2098	5.814e-27	118.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
DTH2_k127_9042332_0	593750.Metfor_0752	9.479e-169	534.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
DTH2_k127_9069770_4	593750.Metfor_2256	0.0006689	46.0	COG1366@1|root,arCOG06891@2157|Archaea,2Y5F7@28890|Euryarchaeota	28890|Euryarchaeota	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
DTH2_k127_9069770_0	593750.Metfor_2255	1.46e-143	475.0	COG2208@1|root,arCOG06893@2157|Archaea,2Y2MD@28890|Euryarchaeota	28890|Euryarchaeota	T	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,SpoIIE
DTH2_k127_9069770_3	411902.CLOBOL_00937	4.177e-18	89.0	COG2172@1|root,COG2172@2|Bacteria,1VAPM@1239|Firmicutes,24J9J@186801|Clostridia,22380@1506553|Lachnoclostridium	186801|Clostridia	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
DTH2_k127_9069770_2	368407.Memar_2012	2.547e-26	117.0	COG3377@1|root,arCOG04424@2157|Archaea,2Y6W5@28890|Euryarchaeota,2NA3P@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF1805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1805
DTH2_k127_9069770_1	368407.Memar_1689	6.919e-30	121.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,2N99Z@224756|Methanomicrobia	224756|Methanomicrobia	F	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
DTH2_k127_9110936_3	368407.Memar_0740	1.335e-43	164.0	COG4066@1|root,arCOG03215@2157|Archaea,2Y0A8@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0305 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2115
DTH2_k127_9110936_0	679926.Mpet_0680	2.229e-65	231.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYGC@28890|Euryarchaeota,2NAUV@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DTH2_k127_9110936_2	368407.Memar_0737	2.219e-55	201.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DTH2_k127_9110936_1	368407.Memar_0736	3.683e-56	198.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,2N9KA@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
DTH2_k127_9127943_1	1379281.AVAG01000035_gene1791	5.784e-75	260.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,42PD0@68525|delta/epsilon subdivisions,2WJV3@28221|Deltaproteobacteria,2MGJJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
DTH2_k127_9127943_0	593750.Metfor_2854	5.481e-174	555.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,2N9EX@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM SufBD protein	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
DTH2_k127_9127943_2	368407.Memar_2225	2.336e-21	97.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,2N9U4@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
DTH2_k127_9206018_3	368407.Memar_1447	5.356e-115	384.0	COG0079@1|root,arCOG04273@2157|Archaea,2XV1E@28890|Euryarchaeota,2N9D3@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,zf-like
DTH2_k127_9206018_4	368407.Memar_1448	2.248e-21	94.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	RHH_1
DTH2_k127_9206018_0	368407.Memar_1449	2.441e-186	592.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,2N934@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ-1	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
DTH2_k127_9206018_1	593750.Metfor_1768	5.534e-131	422.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,2N93Q@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9206018_2	368407.Memar_1451	3.51e-124	405.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2N948@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
DTH2_k127_9211275_1	593750.Metfor_1115	5.574e-36	139.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
DTH2_k127_9211275_0	368407.Memar_1957	2.182e-59	210.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,2N9RR@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM methyltransferase small	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
DTH2_k127_9211275_2	391623.TERMP_00629	3.711e-21	98.0	COG1708@1|root,arCOG02105@2157|Archaea,2XZBB@28890|Euryarchaeota	28890|Euryarchaeota	S	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
DTH2_k127_9211275_3	431943.CKL_1244	3.018e-07	56.0	COG2445@1|root,COG2445@2|Bacteria,1VF87@1239|Firmicutes,24HS2@186801|Clostridia,36IYH@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
DTH2_k127_9225381_2	456442.Mboo_0522	3.342e-27	117.0	arCOG03906@1|root,arCOG03906@2157|Archaea,2XUWK@28890|Euryarchaeota	28890|Euryarchaeota	DZ	Domain of unknown function (DUF3821)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3821
DTH2_k127_9225381_1	192952.MM_1902	9.009e-54	194.0	COG1247@1|root,arCOG00830@2157|Archaea,2XXA1@28890|Euryarchaeota,2NAY3@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
DTH2_k127_9225381_0	304371.MCP_2329	1.738e-68	244.0	arCOG01744@1|root,arCOG01744@2157|Archaea	2157|Archaea	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
DTH2_k127_9248495_2	368407.Memar_1020	6.356e-23	100.0	COG4866@1|root,arCOG05191@2157|Archaea	2157|Archaea	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
DTH2_k127_9248495_1	368407.Memar_1021	7.132e-43	164.0	COG0454@1|root,arCOG00839@2157|Archaea,2Y20T@28890|Euryarchaeota,2NA2S@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
DTH2_k127_9248495_3	416348.Hlac_1676	5.527e-05	51.0	arCOG09323@1|root,arCOG09323@2157|Archaea,2XY9B@28890|Euryarchaeota,23WEE@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH2_k127_9306384_2	521011.Mpal_0280	4.129e-24	112.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,2N9K7@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
DTH2_k127_9306384_0	456442.Mboo_0265	7.367e-73	252.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,2N9J8@224756|Methanomicrobia	224756|Methanomicrobia	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
DTH2_k127_9306384_1	368407.Memar_2208	3.282e-53	192.0	COG0720@1|root,arCOG02172@2157|Archaea,2XX1X@28890|Euryarchaeota,2NBDZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM 6-pyruvoyl tetrahydropterin synthase and	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
DTH2_k127_9306384_3	1123393.KB891316_gene1512	7.332e-16	81.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2VGZ7@28216|Betaproteobacteria,1KSQN@119069|Hydrogenophilales	119069|Hydrogenophilales	O	4Fe-4S single cluster domain	-	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
DTH2_k127_9341433_1	572546.Arcpr_1847	1.487e-27	113.0	COG0411@1|root,arCOG00926@2157|Archaea,2XU0T@28890|Euryarchaeota,245P6@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DTH2_k127_9341433_0	1173027.Mic7113_5146	2.456e-40	165.0	COG2203@1|root,COG3920@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3920@2|Bacteria,COG4191@2|Bacteria,1GPXH@1117|Cyanobacteria,1HHTQ@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	ETR1	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_3,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9
DTH2_k127_9392652_0	521011.Mpal_1199	3.399e-158	512.0	COG0557@1|root,arCOG04686@2157|Archaea,2XT2E@28890|Euryarchaeota,2NA9N@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
DTH2_k127_9392652_1	593750.Metfor_2229	2.155e-75	256.0	COG1600@1|root,arCOG02740@2157|Archaea,2Y2RT@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DTH2_k127_9418158_1	456442.Mboo_0249	1.252e-34	134.0	COG1287@1|root,arCOG02043@2157|Archaea,2XU8G@28890|Euryarchaeota,2N921@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
DTH2_k127_9418158_0	368407.Memar_2236	6.994e-115	379.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,2NAVM@224756|Methanomicrobia	224756|Methanomicrobia	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
DTH2_k127_9567862_1	368407.Memar_0819	4.85e-66	228.0	COG1712@1|root,arCOG00254@2157|Archaea,2XXKF@28890|Euryarchaeota,2N96R@224756|Methanomicrobia	224756|Methanomicrobia	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21,5.3.3.2	ko:K01823,ko:K06989	ko00760,ko00900,ko01100,ko01110,ko01130,map00760,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123,R07407,R07410	RC00455,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF108,NAD_binding_3
DTH2_k127_9567862_0	368407.Memar_0821	5.881e-85	290.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,2N950@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
DTH2_k127_9576193_8	368407.Memar_1800	2.998e-55	199.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
DTH2_k127_9576193_5	679926.Mpet_0749	2.69e-64	224.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,2N9QT@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
DTH2_k127_9576193_4	593750.Metfor_0484	8.576e-71	241.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,2N9RP@224756|Methanomicrobia	224756|Methanomicrobia	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
DTH2_k127_9576193_1	593750.Metfor_0485	1.403e-110	370.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
DTH2_k127_9576193_9	456442.Mboo_2221	3.008e-45	167.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2N9UH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
DTH2_k127_9576193_7	368407.Memar_1805	1.049e-55	198.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,2N9Q5@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
DTH2_k127_9576193_6	694440.JOMF01000005_gene38	1.228e-62	218.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2N9S9@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
DTH2_k127_9576193_10	694440.JOMF01000005_gene39	3.193e-30	121.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,2NA2D@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
DTH2_k127_9576193_12	368407.Memar_1808	7.243e-21	93.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,2NA2R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
DTH2_k127_9576193_0	456442.Mboo_2216	1.07e-182	578.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,2NAG2@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DTH2_k127_9576193_2	456442.Mboo_2215	1.688e-105	346.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,2N9BZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
DTH2_k127_9576193_3	368407.Memar_1811	9.479e-103	342.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,2N9H3@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
DTH2_k127_9576193_11	368407.Memar_1812	7.664e-27	110.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2N96Q@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DTH2_k127_9843919_6	694440.JOMF01000007_gene778	8.771e-41	152.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,2NB55@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM sigma-70 region 4 domain protein	-	-	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
DTH2_k127_9843919_0	521011.Mpal_0442	1.213e-146	471.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,2N98A@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
DTH2_k127_9843919_2	368407.Memar_0565	8.651e-101	333.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,2N9DG@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
DTH2_k127_9843919_7	521011.Mpal_0444	3.074e-31	126.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,2N9ZC@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
DTH2_k127_9843919_1	368407.Memar_0567	1.196e-114	373.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,2N99T@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
DTH2_k127_9843919_3	368407.Memar_0568	9.199e-62	214.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,2N9PW@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
DTH2_k127_9843919_5	368407.Memar_0569	1.076e-51	198.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,2N9UR@224756|Methanomicrobia	224756|Methanomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
DTH2_k127_9843919_4	456442.Mboo_0538	9.066e-52	186.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,2N95N@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
DTH2_k127_9945400_1	1089548.KI783301_gene1591	6.798e-33	132.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,4HAFT@91061|Bacilli,3WFCE@539002|Bacillales incertae sedis	91061|Bacilli	H	MoeA N-terminal region (domain I and II)	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
DTH2_k127_9945400_0	368407.Memar_0405	1.454e-220	698.0	COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,2N9DX@224756|Methanomicrobia	224756|Methanomicrobia	H	MoeA domain protein domain I and II	moeA-1	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
## 981 queries scanned
## Total time (seconds): 25.78209352493286
## Rate: 38.05 q/s