## Tue Oct 15 18:05:04 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/DTH3_bin.52.fa -m mmseqs --itype genome -o DTH3_bin.52 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/DTH3_bin.52 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
DTH3_k127_1006234_1	186497.PF1357	3.803e-49	178.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,243ND@183968|Thermococci	28890|Euryarchaeota	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
DTH3_k127_1006234_0	368408.Tpen_1719	2.473e-124	412.0	COG1004@1|root,arCOG00253@2157|Archaea,2XQ60@28889|Crenarchaeota	28889|Crenarchaeota	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DTH3_k127_1006234_2	479434.Sthe_1148	5.098e-38	151.0	COG0688@1|root,COG0688@2|Bacteria,2G9SQ@200795|Chloroflexi	200795|Chloroflexi	I	PFAM phosphatidylserine decarboxylase-related	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
DTH3_k127_1096342_3	1196031.ALEG01000008_gene5098	8.496e-17	88.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HJN1@91061|Bacilli,1ZFAP@1386|Bacillus	91061|Bacilli	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	stoA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
DTH3_k127_1096342_1	742735.HMPREF9467_00193	1.588e-23	110.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia	186801|Clostridia	IQ	Psort location Cytoplasmic, score	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DTH3_k127_1096342_0	1348908.KI518587_gene2918	6.112e-57	207.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1ZCDY@1386|Bacillus	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
DTH3_k127_1096342_2	1122223.KB890687_gene2892	1.688e-19	93.0	COG2905@1|root,COG2905@2|Bacteria,1WJV4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_1113776_0	720554.Clocl_1771	2.039e-100	331.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,3WGQE@541000|Ruminococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
DTH3_k127_1113776_4	1365176.N186_07220	2.591e-17	88.0	arCOG03871@1|root,arCOG03871@2157|Archaea,2XRGZ@28889|Crenarchaeota	28889|Crenarchaeota	N	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1113776_2	558152.IQ37_06995	6.476e-51	192.0	COG1073@1|root,COG1073@2|Bacteria,4PFZM@976|Bacteroidetes,1IISB@117743|Flavobacteriia,3ZS27@59732|Chryseobacterium	976|Bacteroidetes	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1113776_5	273075.Ta0785	2.534e-16	87.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y1QQ@28890|Euryarchaeota,242HN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
DTH3_k127_1113776_1	2325.TKV_c18760	3.583e-92	313.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
DTH3_k127_1113776_3	646529.Desaci_1421	3.099e-43	162.0	COG3370@1|root,COG3370@2|Bacteria,1VC7H@1239|Firmicutes,24PJC@186801|Clostridia,265XN@186807|Peptococcaceae	186801|Clostridia	S	PFAM DsrE DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
DTH3_k127_1113923_10	272844.PAB2103	3.634e-41	157.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,243UY@183968|Thermococci	183968|Thermococci	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
DTH3_k127_1113923_13	368408.Tpen_0312	1.464e-38	151.0	COG0521@1|root,arCOG00214@2157|Archaea,2XQH2@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM molybdenum cofactor synthesis domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
DTH3_k127_1113923_6	439481.Aboo_1203	4.68e-84	288.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,3F33B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
DTH3_k127_1113923_2	391623.TERMP_00216	4.361e-172	558.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
DTH3_k127_1113923_3	289376.THEYE_A0111	6.349e-170	542.0	COG0499@1|root,COG0499@2|Bacteria,3J0AH@40117|Nitrospirae	40117|Nitrospirae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
DTH3_k127_1113923_7	1041930.Mtc_1045	6.546e-75	265.0	arCOG01186@1|root,arCOG01186@2157|Archaea	2157|Archaea	G	Mn2 dependent serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
DTH3_k127_1113923_9	1041930.Mtc_1046	3.555e-47	176.0	COG0529@1|root,arCOG01040@2157|Archaea,2XU4H@28890|Euryarchaeota,2NBDX@224756|Methanomicrobia	224756|Methanomicrobia	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
DTH3_k127_1113923_17	933262.AXAM01000005_gene2471	1.122e-26	113.0	COG1545@1|root,COG1545@2|Bacteria,1NPAR@1224|Proteobacteria,42WW8@68525|delta/epsilon subdivisions,2WSYD@28221|Deltaproteobacteria,2MM8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
DTH3_k127_1113923_12	930945.SiRe_1200	7.14e-39	155.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
DTH3_k127_1113923_20	1184251.TCELL_0036	1.615e-17	91.0	arCOG04054@1|root,arCOG04054@2157|Archaea,2XPUY@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRC
DTH3_k127_1113923_18	1006006.Mcup_0109	6.943e-25	114.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1113923_5	1459636.NTE_03020	5.859e-121	399.0	COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota	651137|Thaumarchaeota	D	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,MIT,Vps4_C
DTH3_k127_1113923_22	1536770.R50345_03650	9.634e-07	57.0	COG1522@1|root,COG1522@2|Bacteria,1V45K@1239|Firmicutes,4HH2H@91061|Bacilli,26YRG@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	lrpB	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
DTH3_k127_1113923_8	1408323.JQKK01000007_gene696	5.047e-48	182.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,27IAJ@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH3_k127_1113923_14	1163730.FFONT_0132	3.182e-29	124.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
DTH3_k127_1113923_19	399550.Smar_1276	5.451e-21	100.0	arCOG04054@1|root,arCOG04054@2157|Archaea,2XPUY@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRC
DTH3_k127_1113923_4	1379698.RBG1_1C00001G1833	1.056e-121	403.0	COG1379@1|root,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
DTH3_k127_1113923_1	1459636.NTE_01640	9.492e-197	623.0	COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
DTH3_k127_1113923_15	1229909.NSED_05155	4.646e-28	115.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
DTH3_k127_1113923_16	1220534.B655_0542	2.527e-27	119.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,23P32@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
DTH3_k127_1113923_21	1459636.NTE_00679	4.237e-11	65.0	arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1113923_0	1365176.N186_05140	1.883e-220	699.0	COG0441@1|root,arCOG00401@2157|Archaea,2XQ02@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
DTH3_k127_1113923_11	342949.PNA2_0706	1.797e-39	157.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DTH3_k127_1119239_0	1094980.Mpsy_2824	1.366e-53	213.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,arCOG02349@1|root,arCOG02352@1|root,arCOG02376@1|root,arCOG04001@1|root,arCOG02349@2157|Archaea,arCOG02352@2157|Archaea,arCOG02357@2157|Archaea,arCOG02376@2157|Archaea,arCOG02391@2157|Archaea,arCOG02591@2157|Archaea,arCOG04001@2157|Archaea,arCOG06918@2157|Archaea,2Y82D@28890|Euryarchaeota,2NBNN@224756|Methanomicrobia	2157|Archaea	T	Histidine Phosphotransfer domain	-	-	-	ko:K03413,ko:K07662,ko:K07667,ko:K11443	ko01503,ko02020,ko02024,ko02030,ko04112,map01503,map02020,map02024,map02030,map04112	M00447,M00454,M00506,M00511,M00727,M00728	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
DTH3_k127_116150_14	985053.VMUT_1216	0.0001682	46.0	COG1460@1|root,arCOG01016@2157|Archaea,2XRD2@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
DTH3_k127_116150_5	374847.Kcr_0368	1.367e-59	218.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
DTH3_k127_116150_16	1245469.S58_68130	0.0006157	48.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2TVHI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome D1 heme domain	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
DTH3_k127_116150_8	469381.Dpep_1537	1.261e-36	144.0	COG4732@1|root,COG4732@2|Bacteria,3TB6R@508458|Synergistetes	508458|Synergistetes	S	TIGRFAM thiW protein	thiW	-	-	-	-	-	-	-	-	-	-	-	ThiW
DTH3_k127_116150_10	1121403.AUCV01000015_gene4723	1.978e-17	90.0	COG1341@1|root,COG1341@2|Bacteria	2|Bacteria	S	polynucleotide 5'-hydroxyl-kinase activity	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
DTH3_k127_116150_13	573063.Metin_0350	9.376e-06	56.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_116150_1	357808.RoseRS_2771	3.644e-124	411.0	COG1457@1|root,COG1457@2|Bacteria,2G9KC@200795|Chloroflexi,376PN@32061|Chloroflexia	32061|Chloroflexia	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
DTH3_k127_116150_0	374847.Kcr_0867	4.579e-152	493.0	COG0351@1|root,arCOG00020@2157|Archaea	2157|Archaea	H	Phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K21219,ko:K21220	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
DTH3_k127_116150_11	485913.Krac_1305	1.197e-16	83.0	COG1308@1|root,COG1308@2|Bacteria	2|Bacteria	K	protein transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
DTH3_k127_116150_4	457570.Nther_2188	1.748e-75	274.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
DTH3_k127_116150_2	572478.Vdis_0369	1.551e-89	302.0	COG1830@1|root,arCOG04044@2157|Archaea,2XPUI@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	fba	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
DTH3_k127_116150_9	333138.LQ50_21220	1.329e-17	95.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1TR2P@1239|Firmicutes,4HAQN@91061|Bacilli,1ZS1A@1386|Bacillus	91061|Bacilli	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glycos_transf_2,Polysacc_deac_1
DTH3_k127_116150_6	1499967.BAYZ01000177_gene5729	4.793e-49	185.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
DTH3_k127_116150_15	479433.Caci_1445	0.0002994	52.0	COG3325@1|root,COG3325@2|Bacteria,2I2ZC@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 18	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_4_9,Glyco_hydro_18
DTH3_k127_116150_7	1459636.NTE_00462	4.179e-44	170.0	COG0455@1|root,arCOG00589@2157|Archaea	2157|Archaea	D	COG0455 ATPases involved in chromosome partitioning	-	-	-	ko:K03496,ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
DTH3_k127_116150_12	224325.AF_0529	1.311e-07	58.0	arCOG07522@1|root,arCOG07522@2157|Archaea,2Y1I3@28890|Euryarchaeota,247FV@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_116150_3	1121403.AUCV01000039_gene4362	1.187e-86	295.0	COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2MN1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
DTH3_k127_1175871_6	694429.Pyrfu_1064	4.164e-22	107.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_1175871_4	370438.PTH_1653	2.571e-29	119.0	COG1254@1|root,COG1254@2|Bacteria,1VC7N@1239|Firmicutes,259HS@186801|Clostridia,2633Z@186807|Peptococcaceae	186801|Clostridia	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
DTH3_k127_1175871_7	521011.Mpal_2600	7.306e-18	91.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
DTH3_k127_1175871_1	304371.MCP_0975	6.296e-36	138.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y72M@28890|Euryarchaeota,2NB71@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
DTH3_k127_1175871_5	304371.MCP_0976	3.467e-28	115.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y25G@28890|Euryarchaeota	28890|Euryarchaeota	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
DTH3_k127_1175871_0	304371.MCP_0977	5.053e-50	179.0	COG4802@1|root,arCOG01099@2157|Archaea,2Y47M@28890|Euryarchaeota,2NB0P@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
DTH3_k127_1175871_2	304371.MCP_0978	1.035e-31	128.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y74T@28890|Euryarchaeota,2NBB7@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
DTH3_k127_1175871_3	237368.SCABRO_01833	3.558e-30	136.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	2.7.8.20	ko:K01002,ko:K20534	ko01100,map01100	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	GT87,Glycos_transf_2
DTH3_k127_119686_1	877455.Metbo_0294	2.366e-22	102.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23PS9@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_119686_2	926690.KE386573_gene340	2.021e-12	73.0	COG1917@1|root,arCOG02999@2157|Archaea,2XZ2S@28890|Euryarchaeota,23X15@183963|Halobacteria	183963|Halobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DTH3_k127_119686_0	521045.Kole_0198	8.026e-33	136.0	COG1814@1|root,COG1814@2|Bacteria,2GDXP@200918|Thermotogae	200918|Thermotogae	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
DTH3_k127_1198790_3	374847.Kcr_0835	5.286e-55	203.0	COG1478@1|root,arCOG02714@2157|Archaea	2157|Archaea	E	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	GO:0003674,GO:0003824,GO:0016874,GO:0016879,GO:0016881,GO:0052618	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
DTH3_k127_1198790_1	1229909.NSED_09600	3.462e-171	547.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DTH3_k127_1198790_0	272844.PAB1172	2.758e-198	629.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
DTH3_k127_1198790_2	591019.Shell_1353	3.099e-135	444.0	COG0403@1|root,arCOG00077@2157|Archaea,2XQ1W@28889|Crenarchaeota	28889|Crenarchaeota	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
DTH3_k127_1266590_6	1220534.B655_1656	6.264e-27	116.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23P4J@183925|Methanobacteria	183925|Methanobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DTH3_k127_1266590_3	401526.TcarDRAFT_2161	6.345e-58	206.0	COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,4H44P@909932|Negativicutes	909932|Negativicutes	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
DTH3_k127_1266590_1	634498.mru_2187	1.54e-107	363.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,23NKJ@183925|Methanobacteria	183925|Methanobacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
DTH3_k127_1266590_0	573063.Metin_0709	2.704e-116	387.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23QFZ@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
DTH3_k127_1266590_4	269797.Mbar_A0718	1.927e-38	148.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
DTH3_k127_1266590_2	1459636.NTE_01473	1.838e-107	356.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
DTH3_k127_1266590_5	224719.Abm4_1269	2.259e-30	123.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23PKF@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
DTH3_k127_1266590_8	1280.SAXN108_2806	6.547e-08	64.0	COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,4HGH2@91061|Bacilli,4H1ED@90964|Staphylococcaceae	91061|Bacilli	S	Maltose acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2,Mac
DTH3_k127_1266590_7	572478.Vdis_0458	6.038e-23	109.0	COG0463@1|root,arCOG01385@2157|Archaea	2157|Archaea	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH3_k127_1316188_5	566466.NOR53_2807	1.051e-06	60.0	arCOG09742@1|root,2ZBGR@2|Bacteria,1R9H3@1224|Proteobacteria,1S2HM@1236|Gammaproteobacteria,1J9ND@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1316188_4	164757.Mjls_4463	1.553e-15	83.0	COG3467@1|root,COG3467@2|Bacteria,2IK9H@201174|Actinobacteria,239SR@1762|Mycobacteriaceae	201174|Actinobacteria	S	pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
DTH3_k127_1316188_1	868131.MSWAN_0446	9.789e-43	161.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.1,2.3.1.178	ko:K06718,ko:K22477	ko00220,ko00260,ko01100,ko01120,ko01210,ko01230,map00220,map00260,map01100,map01120,map01210,map01230	M00028,M00033	R00259,R06978	RC00004,RC00064,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
DTH3_k127_1316188_0	243274.THEMA_05620	2.099e-54	201.0	COG1028@1|root,COG1028@2|Bacteria,2GCDH@200918|Thermotogae	200918|Thermotogae	IQ	Short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DTH3_k127_1316188_2	410358.Mlab_1687	1.949e-37	147.0	arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
DTH3_k127_1316188_3	1291050.JAGE01000002_gene3569	5.059e-36	140.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,3WHBS@541000|Ruminococcaceae	186801|Clostridia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
DTH3_k127_1323321_2	488538.SAR116_0390	5.256e-43	166.0	COG0258@1|root,COG0258@2|Bacteria,1MYSI@1224|Proteobacteria,2U60N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	5'-3' exonuclease, N-terminal resolvase-like domain	-	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc_N
DTH3_k127_1323321_0	166318.Syn8016DRAFT_0844	2.366e-91	315.0	COG0749@1|root,COG0749@2|Bacteria	166318.Syn8016DRAFT_0844|-	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1323321_1	352165.HMPREF7215_2560	1.65e-43	164.0	COG0749@1|root,COG0749@2|Bacteria	2|Bacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	-	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_pol_A,RNase_H_2
DTH3_k127_1370744_4	517417.Cpar_1002	2.684e-42	167.0	COG0433@1|root,COG1340@1|root,COG0433@2|Bacteria,COG1340@2|Bacteria,1FEIF@1090|Chlorobi	1090|Chlorobi	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
DTH3_k127_1370744_0	1449126.JQKL01000004_gene620	5.667e-140	456.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2689E@186813|unclassified Clostridiales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
DTH3_k127_1370744_3	335543.Sfum_0345	1.415e-48	186.0	COG2306@1|root,COG2306@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF402)	-	-	-	ko:K07586,ko:K09145	-	-	-	-	ko00000	-	-	-	DUF402
DTH3_k127_1370744_1	118163.Ple7327_0425	1.805e-130	428.0	COG0436@1|root,COG0436@2|Bacteria,1GHX7@1117|Cyanobacteria,3VM7E@52604|Pleurocapsales	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
DTH3_k127_1370744_2	386456.JQKN01000014_gene3125	4.858e-96	327.0	COG2423@1|root,arCOG01035@2157|Archaea,2XTTC@28890|Euryarchaeota,23PUF@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	ala	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
DTH3_k127_1370744_5	368408.Tpen_0195	1.446e-38	158.0	COG5623@1|root,arCOG04127@2157|Archaea,2XPVW@28889|Crenarchaeota	28889|Crenarchaeota	A	PFAM Molybdopterin guanine dinucleotide synthesis protein B	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
DTH3_k127_1370744_7	69781.S7Z6F4	5.392e-14	81.0	COG0468@1|root,KOG1564@2759|Eukaryota,38E66@33154|Opisthokonta,3NY37@4751|Fungi,3QRB4@4890|Ascomycota,20CPK@147545|Eurotiomycetes,3S7GU@5042|Eurotiales	4751|Fungi	L	DNA repair protein	rhp57	GO:0000003,GO:0000150,GO:0000217,GO:0000280,GO:0000400,GO:0000707,GO:0000722,GO:0000723,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0022414,GO:0022607,GO:0030491,GO:0032200,GO:0032991,GO:0033061,GO:0033062,GO:0033063,GO:0033170,GO:0033554,GO:0034622,GO:0034641,GO:0035825,GO:0035861,GO:0042148,GO:0042592,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0045003,GO:0046483,GO:0046982,GO:0046983,GO:0048285,GO:0050896,GO:0051276,GO:0051321,GO:0051716,GO:0060249,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090734,GO:0090735,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046	-	ko:K10880,ko:K10958	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	Rad51
DTH3_k127_1370744_6	426368.MmarC7_0973	2.165e-34	137.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,23QZ6@183939|Methanococci	183939|Methanococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
DTH3_k127_1512580_3	572478.Vdis_0027	4.083e-56	208.0	COG2262@1|root,arCOG00353@2157|Archaea,2XQ0E@28889|Crenarchaeota	28889|Crenarchaeota	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
DTH3_k127_1512580_2	436308.Nmar_1146	9.766e-96	327.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	2157|Archaea	O	Trypsin-like serine protease with C-terminal PDZ domain	degP	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
DTH3_k127_1512580_1	555079.Toce_0910	2.393e-122	403.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42ESV@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DTH3_k127_1512580_0	224719.Abm4_1617	2.846e-204	647.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,23NSE@183925|Methanobacteria	183925|Methanobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DTH3_k127_1533545_1	309799.DICTH_1155	3.235e-75	260.0	COG1045@1|root,COG1045@2|Bacteria	2|Bacteria	E	serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS02865,iYO844.BSU00930	Hexapep,SATase_N
DTH3_k127_1533545_2	1094980.Mpsy_0709	7.418e-30	129.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,2N9E7@224756|Methanomicrobia	224756|Methanomicrobia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DTH3_k127_1533545_3	1232437.KL661967_gene5056	2.582e-15	82.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,2MKAT@213118|Desulfobacterales	28221|Deltaproteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
DTH3_k127_1533545_0	1365176.N186_02690	6.134e-147	481.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
DTH3_k127_1648922_1	178306.PAE2159	4.756e-63	233.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
DTH3_k127_1648922_2	1087448.Eab7_2253	3.367e-17	91.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,4HE7X@91061|Bacilli,3WFN6@539002|Bacillales incertae sedis	91061|Bacilli	S	haloacid dehalogenase-like hydrolase	ppaX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH3_k127_1648922_0	694429.Pyrfu_1705	7.214e-180	577.0	COG0423@1|root,arCOG00405@2157|Archaea,2XPSF@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
DTH3_k127_1650530_6	426355.Mrad2831_5859	6.207e-21	95.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VEXG@28211|Alphaproteobacteria,1JU4A@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH3_k127_1650530_4	751944.HALDL1_10280	8.79e-66	233.0	COG0411@1|root,arCOG00926@2157|Archaea	751944.HALDL1_10280|-	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	-
DTH3_k127_1650530_3	913865.DOT_4546	1.693e-68	239.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,264ZY@186807|Peptococcaceae	186801|Clostridia	E	ABC transporter, ATP-binding protein	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DTH3_k127_1650530_5	1519464.HY22_10255	9.469e-22	104.0	COG0671@1|root,COG0671@2|Bacteria,1FE3Y@1090|Chlorobi	1090|Chlorobi	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
DTH3_k127_1650530_2	698769.JFBD01000019_gene1982	2.037e-69	242.0	COG1878@1|root,COG1878@2|Bacteria,1UZ93@1239|Firmicutes,4IRAF@91061|Bacilli	91061|Bacilli	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DTH3_k127_1650530_7	604354.TSIB_2058	4.582e-12	76.0	arCOG10658@1|root,arCOG10658@2157|Archaea,2Y6VU@28890|Euryarchaeota,2459U@183968|Thermococci	183968|Thermococci	S	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1650530_0	456442.Mboo_1047	3.49e-261	809.0	COG5310@1|root,arCOG05182@2157|Archaea,2Y2E8@28890|Euryarchaeota,2NAFG@224756|Methanomicrobia	224756|Methanomicrobia	Q	Saccharopine dehydrogenase C-terminal domain	-	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2685	Sacchrp_dh_C,Sacchrp_dh_NADP
DTH3_k127_1650530_1	521011.Mpal_2447	2.513e-84	284.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
DTH3_k127_1716728_1	177437.HRM2_03300	0.0001268	44.0	COG0296@1|root,COG0296@2|Bacteria,1NIZI@1224|Proteobacteria,42WYM@68525|delta/epsilon subdivisions,2WSNX@28221|Deltaproteobacteria,2MMER@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Glycogen recognition site of AMP-activated protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
DTH3_k127_175734_10	1128398.Curi_c10450	2.07e-19	91.0	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,24QZK@186801|Clostridia,269ID@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
DTH3_k127_175734_9	1500281.JQKZ01000048_gene3634	1.139e-26	118.0	COG0509@1|root,COG0509@2|Bacteria,4NQ35@976|Bacteroidetes,1I1X5@117743|Flavobacteriia,3ZTST@59732|Chryseobacterium	976|Bacteroidetes	E	Glycine cleavage H-protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
DTH3_k127_175734_13	648996.Theam_1473	7.529e-15	82.0	COG1999@1|root,COG1999@2|Bacteria	2|Bacteria	M	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
DTH3_k127_175734_16	1095727.HMPREF1117_0216	1.466e-05	55.0	COG0785@1|root,COG0785@2|Bacteria,1V440@1239|Firmicutes,4HG5C@91061|Bacilli	91061|Bacilli	O	cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
DTH3_k127_175734_15	748449.Halha_1190	1.718e-11	75.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia	186801|Clostridia	M	RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat
DTH3_k127_175734_3	521011.Mpal_2572	5.064e-56	205.0	COG4063@1|root,arCOG03221@2157|Archaea	2157|Archaea	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrA-2	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
DTH3_k127_175734_12	591157.SSLG_04267	1.594e-16	84.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
DTH3_k127_175734_1	868131.MSWAN_0077	4.36e-65	235.0	COG0798@1|root,arCOG02190@2157|Archaea,2XTQC@28890|Euryarchaeota,23P72@183925|Methanobacteria	183925|Methanobacteria	P	Bile acid sodium symporter	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
DTH3_k127_175734_7	643648.Slip_2188	4.814e-32	130.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,42K4C@68298|Syntrophomonadaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	DGC,GCV_H
DTH3_k127_175734_8	1031288.AXAA01000034_gene2179	2.073e-27	116.0	COG4273@1|root,COG4273@2|Bacteria,1VBRH@1239|Firmicutes,24N2C@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
DTH3_k127_175734_6	1131462.DCF50_p230	2.932e-34	135.0	COG4273@1|root,COG4273@2|Bacteria,1UPTR@1239|Firmicutes,25HNZ@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
DTH3_k127_175734_5	643648.Slip_2185	2.089e-42	160.0	COG1764@1|root,COG1764@2|Bacteria,1VYMJ@1239|Firmicutes,2538T@186801|Clostridia	186801|Clostridia	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
DTH3_k127_175734_0	1047013.AQSP01000109_gene2441	8.85e-106	349.0	COG0500@1|root,COG2226@2|Bacteria,2NP8K@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
DTH3_k127_175734_4	234267.Acid_2668	2.401e-50	192.0	COG0407@1|root,COG0407@2|Bacteria,3Y8YA@57723|Acidobacteria	57723|Acidobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH3_k127_175734_14	536227.CcarbDRAFT_5298	6.382e-12	71.0	2EI58@1|root,33BWK@2|Bacteria,1USZY@1239|Firmicutes,250KH@186801|Clostridia,36RQ0@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_175734_2	768706.Desor_1142	8.986e-64	225.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,2659T@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM methyltransferase cognate corrinoid proteins, Methanosarcina family	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
DTH3_k127_175734_11	192952.MM_2048	1.053e-17	87.0	COG5598@1|root,arCOG03405@2157|Archaea,2Y3FW@28890|Euryarchaeota,2NAQ9@224756|Methanomicrobia	224756|Methanomicrobia	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
DTH3_k127_1811514_6	1280673.AUJJ01000018_gene997	3.281e-13	78.0	COG0778@1|root,COG0778@2|Bacteria,1V9VR@1239|Firmicutes,24Q35@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DTH3_k127_1811514_0	660470.Theba_2261	2.166e-71	243.0	2DH26@1|root,2ZY4Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
DTH3_k127_1811514_1	357808.RoseRS_3668	6.484e-59	208.0	COG0350@1|root,COG0350@2|Bacteria	2|Bacteria	L	methylated-DNA-[protein]-cysteine S-methyltransferase activity	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
DTH3_k127_1811514_3	1267535.KB906767_gene7	2.301e-48	195.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria	57723|Acidobacteria	S	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8,UnbV_ASPIC,VCBS
DTH3_k127_1811514_4	221288.JH992901_gene3767	2.381e-41	167.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DTH3_k127_1811514_2	269797.Mbar_A2814	9.71e-59	207.0	COG1881@1|root,arCOG04702@2157|Archaea,2XXMX@28890|Euryarchaeota,2N9VT@224756|Methanomicrobia	224756|Methanomicrobia	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
DTH3_k127_1811514_5	1196323.ALKF01000147_gene1285	6.566e-20	92.0	COG3708@1|root,COG3708@2|Bacteria,1V30G@1239|Firmicutes,4HGJD@91061|Bacilli,26X9S@186822|Paenibacillaceae	91061|Bacilli	K	Bacterial transcription activator, effector binding domain	yobU	-	-	-	-	-	-	-	-	-	-	-	Cass2,GyrI-like,Zn_ribbon_2
DTH3_k127_1843841_3	374847.Kcr_1466	5.496e-39	151.0	COG2101@1|root,arCOG01764@2157|Archaea	2157|Archaea	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
DTH3_k127_1843841_4	478749.BRYFOR_07299	1.49e-36	152.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia	186801|Clostridia	E	Psort location Cytoplasmic, score	ydjJ	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH3_k127_1843841_0	342949.PNA2_1115	1.852e-56	211.0	COG0297@1|root,COG0438@1|root,arCOG01403@2157|Archaea,arCOG01420@2157|Archaea,2XVAJ@28890|Euryarchaeota,243HN@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DTH3_k127_1843841_5	351160.RCIX210	3.774e-13	81.0	COG5542@1|root,arCOG10055@2157|Archaea	2157|Archaea	S	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
DTH3_k127_1843841_1	1365176.N186_02200	6.22e-49	180.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
DTH3_k127_1843841_2	399550.Smar_0812	5.692e-46	171.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
DTH3_k127_1844506_0	523845.AQXV01000055_gene15	1.236e-96	331.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,23QBS@183939|Methanococci	183939|Methanococci	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2b
DTH3_k127_1844506_1	768672.Desfe_1430	4.257e-52	191.0	COG1890@1|root,arCOG04186@2157|Archaea,2XPNX@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
DTH3_k127_1844506_2	562970.Btus_0198	2.298e-20	94.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,4HB16@91061|Bacilli,277WG@186823|Alicyclobacillaceae	91061|Bacilli	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS11275	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DTH3_k127_1849304_4	397948.Cmaq_1310	5.932e-16	79.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
DTH3_k127_1849304_0	1056495.Calag_0321	1.111e-99	338.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
DTH3_k127_1849304_2	573064.Mefer_0665	2.164e-86	295.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23QC5@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DTH3_k127_1849304_3	1303518.CCALI_02180	5.722e-19	94.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DTH3_k127_1849304_1	391623.TERMP_00481	1.163e-88	303.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
DTH3_k127_1849304_5	1459636.NTE_01448	3.278e-10	67.0	arCOG08765@1|root,arCOG08765@2157|Archaea	1459636.NTE_01448|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1851422_2	415426.Hbut_0543	1.209e-42	159.0	COG1358@1|root,arCOG01751@2157|Archaea,2XQH4@28889|Crenarchaeota	28889|Crenarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
DTH3_k127_1851422_3	591019.Shell_1641	2.702e-27	112.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
DTH3_k127_1851422_4	273063.STK_02804	6.946e-18	84.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
DTH3_k127_1851422_1	589924.Ferp_0618	4.259e-45	169.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
DTH3_k127_1851422_0	694429.Pyrfu_1882	1.771e-189	608.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
DTH3_k127_1862555_2	338966.Ppro_0597	1.782e-18	88.0	COG1143@1|root,COG1143@2|Bacteria,1RK71@1224|Proteobacteria,42Y1X@68525|delta/epsilon subdivisions,2WQB3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K14091	-	-	-	-	ko00000	-	-	-	ETF_QO,Fer4,Fer4_7
DTH3_k127_1862555_4	326427.Cagg_1625	3.812e-06	51.0	COG0839@1|root,COG0839@2|Bacteria,2G777@200795|Chloroflexi,375K1@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
DTH3_k127_1862555_3	593117.TGAM_0041	7.521e-15	79.0	COG1006@1|root,arCOG03072@2157|Archaea,2XXR9@28890|Euryarchaeota,24499@183968|Thermococci	183968|Thermococci	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
DTH3_k127_1862555_0	1449063.JMLS01000022_gene6443	8.587e-120	407.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,4H9YR@91061|Bacilli,26SE0@186822|Paenibacillaceae	91061|Bacilli	CP	Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
DTH3_k127_1862555_1	329726.AM1_2126	7.831e-32	134.0	COG1008@1|root,COG1008@2|Bacteria,1G0VB@1117|Cyanobacteria	1117|Cyanobacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ndhD2	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhD2	Oxidored_q5_N,Proton_antipo_M
DTH3_k127_1885485_3	1042877.GQS_10135	4.272e-41	161.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,243IC@183968|Thermococci	183968|Thermococci	E	Glutamine amidotransferase domain	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
DTH3_k127_1885485_1	1054217.TALC_01492	4.046e-122	402.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,241W7@183967|Thermoplasmata	183967|Thermoplasmata	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
DTH3_k127_1885485_0	1236689.MMALV_11490	5.624e-124	406.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,3F2F1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
DTH3_k127_1885485_4	868131.MSWAN_0444	4.741e-27	114.0	COG0375@1|root,arCOG04426@2157|Archaea,2XZI2@28890|Euryarchaeota,23P60@183925|Methanobacteria	183925|Methanobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
DTH3_k127_1885485_2	579137.Metvu_0183	3.504e-64	227.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,23QIT@183939|Methanococci	183939|Methanococci	O	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
DTH3_k127_1919863_27	436308.Nmar_0581	5.071e-06	50.0	COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
DTH3_k127_1919863_16	452637.Oter_2385	1.503e-25	112.0	COG1694@1|root,COG1694@2|Bacteria,46W6C@74201|Verrucomicrobia,3K875@414999|Opitutae	414999|Opitutae	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
DTH3_k127_1919863_6	573064.Mefer_0922	8.44e-109	380.0	COG1328@1|root,arCOG03714@1|root,arCOG03714@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,23Q3Z@183939|Methanococci	183939|Methanococci	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,NRDD
DTH3_k127_1919863_5	529709.PYCH_07500	7.592e-110	363.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DTH3_k127_1919863_3	665571.STHERM_c07830	6.047e-146	471.0	COG2021@1|root,COG2021@2|Bacteria,2JA6P@203691|Spirochaetes	203691|Spirochaetes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
DTH3_k127_1919863_12	1041930.Mtc_0455	2.303e-48	177.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2N9RS@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
DTH3_k127_1919863_21	386456.JQKN01000007_gene3350	2.729e-13	74.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y1TB@28890|Euryarchaeota,23P7Q@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	ahaF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
DTH3_k127_1919863_9	436114.SYO3AOP1_1258	1.683e-71	246.0	COG0605@1|root,COG0605@2|Bacteria,2G4HC@200783|Aquificae	200783|Aquificae	C	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
DTH3_k127_1919863_8	386456.JQKN01000003_gene421	3.889e-84	289.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23NZS@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
DTH3_k127_1919863_4	868131.MSWAN_0958	2.528e-120	393.0	COG2037@1|root,arCOG02695@2157|Archaea,2XUV2@28890|Euryarchaeota,23NJN@183925|Methanobacteria	183925|Methanobacteria	C	Formylmethanofuran-tetrahydromethanopterin formyltransferase	ftr1	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
DTH3_k127_1919863_7	868131.MSWAN_0957	3.141e-87	300.0	COG4030@1|root,arCOG01161@2157|Archaea,2XWWH@28890|Euryarchaeota,23NXN@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF2961)	ehaR	-	-	ko:K14109	-	-	-	-	ko00000	-	-	-	-
DTH3_k127_1919863_10	304371.MCP_2597	5.14e-70	255.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
DTH3_k127_1919863_11	1519464.HY22_13825	1.125e-68	244.0	COG0345@1|root,COG0345@2|Bacteria,1FE2A@1090|Chlorobi	1090|Chlorobi	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
DTH3_k127_1919863_26	56110.Oscil6304_0132	1.053e-06	54.0	COG0425@1|root,COG0425@2|Bacteria,1G7QS@1117|Cyanobacteria,1HC2F@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
DTH3_k127_1919863_22	269799.Gmet_3453	1.543e-11	76.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,42V4B@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Sulphur transport	soxT	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
DTH3_k127_1919863_25	478801.Ksed_00550	1.31e-09	65.0	COG2391@1|root,COG2391@2|Bacteria,2GNSI@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp,TusA
DTH3_k127_1919863_17	269797.Mbar_A0578	5.591e-23	112.0	COG0348@1|root,arCOG02772@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
DTH3_k127_1919863_23	5911.EAR97143	3.878e-10	70.0	COG1310@1|root,KOG1555@2759|Eukaryota,3ZCWI@5878|Ciliophora	5878|Ciliophora	O	Prokaryotic homologs of the JAB domain	-	-	-	ko:K03030	ko03050,ko05169,map03050,map05169	M00341	-	-	ko00000,ko00001,ko00002,ko01002,ko03051,ko04121	-	-	-	JAB,MitMem_reg
DTH3_k127_1919863_19	436308.Nmar_0544	2.138e-21	99.0	COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DTH3_k127_1919863_2	593750.Metfor_1721	0.0	1073.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,2N9CY@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	-	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
DTH3_k127_1919863_13	351160.LRC458	2.16e-47	176.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota,2NA4Z@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
DTH3_k127_1919863_24	264732.Moth_1233	1.067e-09	66.0	COG4708@1|root,COG4708@2|Bacteria,1V9YK@1239|Firmicutes,24N9H@186801|Clostridia,42GUX@68295|Thermoanaerobacterales	186801|Clostridia	S	QueT transporter	queT	-	-	-	-	-	-	-	-	-	-	-	QueT
DTH3_k127_1919863_18	523850.TON_0216	5.576e-22	97.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,244K3@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
DTH3_k127_1919863_1	1459636.NTE_02750	0.0	1302.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
DTH3_k127_1919863_0	1459636.NTE_02749	0.0	1425.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
DTH3_k127_1919863_20	415426.Hbut_1576	3.445e-21	96.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
DTH3_k127_1919863_14	1163730.FFONT_0598	1.783e-39	151.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
DTH3_k127_1919863_15	573064.Mefer_1275	4.722e-34	136.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,23Q6M@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
DTH3_k127_1953272_5	342949.PNA2_1380	3.452e-14	75.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,2447N@183968|Thermococci	183968|Thermococci	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
DTH3_k127_1953272_2	1220534.B655_0054	1.613e-84	297.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,23NQR@183925|Methanobacteria	183925|Methanobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
DTH3_k127_1953272_4	1459636.NTE_03282	4.215e-31	129.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_1953272_0	386456.JQKN01000001_gene2034	2.982e-108	376.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,23NMS@183925|Methanobacteria	183925|Methanobacteria	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
DTH3_k127_1953272_6	195522.BD01_1581	5.854e-06	55.0	arCOG05775@1|root,arCOG05775@2157|Archaea,2XXSH@28890|Euryarchaeota,244BF@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_1953272_1	1343739.PAP_10275	1.941e-102	343.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
DTH3_k127_1953272_3	1345695.CLSA_c13120	1.421e-50	185.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DTH3_k127_2030630_0	485913.Krac_4630	9.803e-66	235.0	COG2084@1|root,COG2084@2|Bacteria,2G8J4@200795|Chloroflexi	200795|Chloroflexi	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
DTH3_k127_2031068_0	671143.DAMO_0611	3.924e-42	172.0	COG1216@1|root,COG1216@2|Bacteria,2NRAF@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	GT87
DTH3_k127_2062526_6	224325.AF_0566	1.468e-11	68.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y7D1@28890|Euryarchaeota,246J1@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
DTH3_k127_2062526_1	1408422.JHYF01000003_gene903	4.986e-44	170.0	COG1526@1|root,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,36HJU@31979|Clostridiaceae	186801|Clostridia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
DTH3_k127_2062526_3	243164.DET0395	2.563e-26	116.0	COG0637@1|root,COG1214@1|root,COG0637@2|Bacteria,COG1214@2|Bacteria,2G6ZZ@200795|Chloroflexi,34D2B@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Glycoprotease family	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Peptidase_M22
DTH3_k127_2062526_0	565033.GACE_1086	2.75e-60	209.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,2467Y@183980|Archaeoglobi	183980|Archaeoglobi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
DTH3_k127_2062526_4	521011.Mpal_1670	2.821e-16	80.0	COG0425@1|root,arCOG02062@2157|Archaea	2157|Archaea	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	TusA
DTH3_k127_2062526_7	522772.Dacet_2830	4.774e-08	55.0	COG0537@1|root,COG0537@2|Bacteria,2GFI1@200930|Deferribacteres	200930|Deferribacteres	FG	Protein similar to CwfJ C-terminus 1	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
DTH3_k127_2062526_5	861299.J421_3199	5.421e-14	77.0	COG0824@1|root,COG0824@2|Bacteria,1ZTY3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
DTH3_k127_2062526_2	304371.MCP_2644	2.245e-38	149.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2NB5B@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_6
DTH3_k127_2131124_3	525904.Tter_2623	3.699e-88	301.0	COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria	2|Bacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	fbiC	-	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,Radical_SAM
DTH3_k127_2131124_8	573063.Metin_1271	7.001e-61	218.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,23QM6@183939|Methanococci	183939|Methanococci	H	PFAM bifunctional deaminase-reductase domain protein	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C,Toprim_2
DTH3_k127_2131124_5	1459636.NTE_03546	1.003e-71	257.0	COG0402@1|root,arCOG00692@2157|Archaea,41S61@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
DTH3_k127_2131124_7	877455.Metbo_2437	1.756e-68	242.0	COG2429@1|root,arCOG04202@2157|Archaea,2XSWH@28890|Euryarchaeota,23NUD@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity	gch3	-	3.5.4.29	ko:K08096	ko00740,ko01100,map00740,map01100	-	R07306	RC01790	ko00000,ko00001,ko01000	-	-	-	GCH_III
DTH3_k127_2131124_11	323259.Mhun_3201	1.119e-26	114.0	COG0745@1|root,arCOG02595@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
DTH3_k127_2131124_6	1379698.RBG1_1C00001G1718	1.481e-68	247.0	COG0438@1|root,COG0438@2|Bacteria,2NNZH@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
DTH3_k127_2131124_4	518766.Rmar_2615	1.051e-73	258.0	COG2152@1|root,COG2152@2|Bacteria,4NG7B@976|Bacteroidetes	976|Bacteroidetes	G	PFAM glycosidase, PH1107-related	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
DTH3_k127_2131124_2	518766.Rmar_1363	3.08e-100	346.0	COG0438@1|root,COG0438@2|Bacteria,4NEW7@976|Bacteroidetes	976|Bacteroidetes	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DTH3_k127_2131124_13	204536.SULAZ_1315	2.524e-11	76.0	COG0517@1|root,COG2199@1|root,COG2905@1|root,COG0517@2|Bacteria,COG2905@2|Bacteria,COG3706@2|Bacteria,2G47E@200783|Aquificae	200783|Aquificae	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GGDEF
DTH3_k127_2131124_1	1487923.DP73_14175	3.554e-107	357.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,261Z4@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH3_k127_2131124_0	1231391.AMZF01000037_gene583	3.922e-110	364.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2VI5X@28216|Betaproteobacteria,3T6F3@506|Alcaligenaceae	28216|Betaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DTH3_k127_2131124_10	694429.Pyrfu_1064	7.499e-47	185.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_2131124_12	391603.FBALC1_14667	8.485e-21	97.0	COG5580@1|root,COG5580@2|Bacteria,4PK53@976|Bacteroidetes,1I3SX@117743|Flavobacteriia	976|Bacteroidetes	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
DTH3_k127_2131124_9	350688.Clos_0456	6.693e-50	184.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,36DF4@31979|Clostridiaceae	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DTH3_k127_2167379_2	1349785.BAUG01000036_gene1991	0.000958	45.0	COG3266@1|root,COG4886@1|root,COG3266@2|Bacteria,COG4886@2|Bacteria,4NMJ3@976|Bacteroidetes,1I2GQ@117743|Flavobacteriia	976|Bacteroidetes	P	leucine- rich repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LRR_4
DTH3_k127_2167379_1	311424.DhcVS_1244	1.45e-17	92.0	2EHX5@1|root,33BNR@2|Bacteria,2GATV@200795|Chloroflexi,34DBX@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_2167379_0	386456.JQKN01000002_gene2753	6.033e-23	111.0	COG0392@1|root,arCOG00899@2157|Archaea,2XTI1@28890|Euryarchaeota,23NKG@183925|Methanobacteria	183925|Methanobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
DTH3_k127_2168383_1	1459636.NTE_02288	6.836e-91	312.0	COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF1512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
DTH3_k127_2168383_2	391623.TERMP_00696	1.348e-75	263.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DTH3_k127_2168383_0	1459636.NTE_01984	3.508e-152	490.0	COG0012@1|root,arCOG00357@2157|Archaea,41S8X@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
DTH3_k127_217027_4	1041930.Mtc_1553	1.368e-32	137.0	COG2968@1|root,arCOG04715@2157|Archaea,2XZAZ@28890|Euryarchaeota,2N9TF@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
DTH3_k127_217027_1	304371.MCP_1481	7.158e-111	365.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_217027_3	589924.Ferp_1683	3.872e-44	177.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_217027_2	589924.Ferp_1339	1.607e-85	293.0	COG0109@1|root,arCOG00479@2157|Archaea,2XUEM@28890|Euryarchaeota,247C6@183980|Archaeoglobi	183980|Archaeoglobi	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
DTH3_k127_217027_0	589924.Ferp_1340	4.871e-234	730.0	COG3256@1|root,arCOG04703@2157|Archaea,2XU3H@28890|Euryarchaeota	28890|Euryarchaeota	P	COG3256 Nitric oxide reductase large subunit	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
DTH3_k127_218922_1	589924.Ferp_1664	2.777e-37	141.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,245NJ@183980|Archaeoglobi	183980|Archaeoglobi	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DTH3_k127_218922_2	589924.Ferp_1663	5.498e-33	130.0	arCOG10225@1|root,arCOG10225@2157|Archaea,2XZRF@28890|Euryarchaeota,246F4@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_218922_0	693661.Arcve_2086	5.968e-95	323.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,24602@183980|Archaeoglobi	183980|Archaeoglobi	E	Imidazole acetol-phosphate transaminase	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH3_k127_2212693_9	401526.TcarDRAFT_0297	1.6e-39	156.0	COG2045@1|root,COG2045@2|Bacteria,1V56I@1239|Firmicutes,4H464@909932|Negativicutes	909932|Negativicutes	H	Belongs to the ComB family	comB	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
DTH3_k127_2212693_1	386456.JQKN01000002_gene2571	1.745e-145	475.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23NK2@183925|Methanobacteria	183925|Methanobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DTH3_k127_2212693_6	1459636.NTE_00618	1.852e-70	243.0	COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
DTH3_k127_2212693_15	490899.DKAM_0885	6.491e-08	61.0	COG0681@1|root,arCOG01739@2157|Archaea	2157|Archaea	U	Signal peptidase	-	GO:0003674,GO:0003824,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:0140096,GO:1901564	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DTH3_k127_2212693_13	536227.CcarbDRAFT_5112	1.056e-13	76.0	COG1695@1|root,COG1695@2|Bacteria,1VA94@1239|Firmicutes,24PWU@186801|Clostridia,36KKH@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
DTH3_k127_2212693_5	1385511.N783_02050	2.243e-80	279.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HD08@91061|Bacilli,2Y9HK@289201|Pontibacillus	91061|Bacilli	E	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH3_k127_2212693_2	484770.UFO1_3738	2.225e-117	389.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,4H3IP@909932|Negativicutes	909932|Negativicutes	H	Belongs to the PdxA family	-	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
DTH3_k127_2212693_4	748449.Halha_1188	2.516e-86	301.0	COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes,24AJF@186801|Clostridia,3WBXK@53433|Halanaerobiales	186801|Clostridia	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
DTH3_k127_2212693_10	273116.14325081	1.613e-36	145.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,241XY@183967|Thermoplasmata	183967|Thermoplasmata	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
DTH3_k127_2212693_7	1094508.Tsac_0624	8.363e-55	203.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,42EZG@68295|Thermoanaerobacterales	186801|Clostridia	M	Transferase hexapeptide repeat	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DTH3_k127_2212693_14	926554.KI912653_gene4149	1.249e-10	74.0	2EZGX@1|root,2ZBAK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_2212693_11	502558.EGYY_10820	7.271e-27	124.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria,4CVYU@84998|Coriobacteriia	84998|Coriobacteriia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DTH3_k127_2212693_8	1459636.NTE_00615	6.819e-47	176.0	COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
DTH3_k127_2212693_12	1410676.JNKL01000013_gene1940	2.73e-23	114.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1Y3K1@135624|Aeromonadales	135624|Aeromonadales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
DTH3_k127_2212693_3	693661.Arcve_0243	2.172e-90	314.0	COG0303@1|root,arCOG00217@2157|Archaea,2Y7W9@28890|Euryarchaeota,247I1@183980|Archaeoglobi	183980|Archaeoglobi	H	Molybdenum cofactor synthesis domain protein	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
DTH3_k127_2212693_0	397948.Cmaq_0710	1.985e-201	644.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH3_k127_2212693_16	1232447.BAHW02000003_gene93	0.0004391	44.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia	186801|Clostridia	G	L-ribulose-5-phosphate 4-epimerase	-	-	4.1.2.17,5.1.3.4	ko:K01628,ko:K03077	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R02262,R05850	RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
DTH3_k127_226664_0	439481.Aboo_0302	4.827e-175	568.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
DTH3_k127_226664_1	1054217.TALC_00961	1.083e-43	166.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242GA@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
DTH3_k127_226664_2	1122915.AUGY01000010_gene4593	7.835e-15	85.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,4H9PI@91061|Bacilli,26UBU@186822|Paenibacillaceae	91061|Bacilli	E	Ethanolamine utilization protein EutJ	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
DTH3_k127_2297932_1	237368.SCABRO_00336	2.516e-45	175.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
DTH3_k127_2297932_0	479434.Sthe_1716	1.42e-120	390.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,27Y0U@189775|Thermomicrobia	189775|Thermomicrobia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
DTH3_k127_2325519_1	635013.TherJR_1577	1.706e-54	196.0	COG1592@1|root,COG1592@2|Bacteria,1V1MI@1239|Firmicutes,24GXJ@186801|Clostridia,261NV@186807|Peptococcaceae	186801|Clostridia	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH3_k127_2325519_0	1347086.CCBA010000025_gene3148	1.465e-69	247.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,1ZDWB@1386|Bacillus	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DTH3_k127_2350489_13	930945.SiRe_1294	5.467e-16	83.0	COG0092@1|root,arCOG04097@2157|Archaea,2XPVQ@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
DTH3_k127_2350489_16	1041930.Mtc_1329	6.051e-09	59.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,2NA4R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
DTH3_k127_2350489_11	868131.MSWAN_1462	1.827e-22	99.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
DTH3_k127_2350489_7	521011.Mpal_0451	3.097e-35	137.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
DTH3_k127_2350489_4	1459636.NTE_01827	4.804e-51	184.0	COG0093@1|root,arCOG04095@2157|Archaea,41SHG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
DTH3_k127_2350489_9	633148.Tagg_0858	1.765e-25	109.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
DTH3_k127_2350489_0	591019.Shell_1432	1.535e-72	252.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
DTH3_k127_2350489_3	1459636.NTE_01824	2.553e-55	198.0	COG0094@1|root,arCOG04092@2157|Archaea,41SJP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
DTH3_k127_2350489_15	72558.CBQ73293	4.221e-13	73.0	COG0199@1|root,KOG3506@2759|Eukaryota,3A8G0@33154|Opisthokonta,3P6KV@4751|Fungi,3V2GP@5204|Basidiomycota,3N1KM@452284|Ustilaginomycotina	4751|Fungi	J	Ribosomal protein S14p/S29e	RPS29	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02980	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
DTH3_k127_2350489_5	342949.PNA2_0366	3.268e-49	180.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
DTH3_k127_2350489_6	529709.PYCH_01540	1.221e-46	176.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,243D5@183968|Thermococci	183968|Thermococci	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
DTH3_k127_2350489_10	673860.AciM339_1115	7.098e-25	110.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,3F2PV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
DTH3_k127_2350489_8	647113.Metok_0784	1.748e-31	129.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23QT2@183939|Methanococci	183939|Methanococci	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
DTH3_k127_2350489_2	604354.TSIB_0308	4.414e-59	211.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,243VI@183968|Thermococci	183968|Thermococci	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
DTH3_k127_2350489_1	768679.TTX_1410	3.731e-69	241.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
DTH3_k127_2350489_14	673860.AciM339_1119	2.713e-15	82.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,3F2NM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein L30p/L7e	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
DTH3_k127_2350489_12	985053.VMUT_1762	7.719e-21	95.0	COG0200@1|root,arCOG00779@2157|Archaea,2XQH0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
DTH3_k127_2454768_0	573063.Metin_1333	2.467e-150	495.0	COG1933@1|root,arCOG03147@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,23Q0E@183939|Methanococci	183939|Methanococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
DTH3_k127_2482092_1	438753.AZC_3598	3.454e-62	222.0	COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QT52@1224|Proteobacteria,2TVNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Toprim-like	-	-	3.6.4.12	ko:K17680	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	DnaB_C,Toprim_2
DTH3_k127_2482092_3	910314.HMPREF9220_0739	2.957e-28	117.0	2E0FP@1|root,32W1T@2|Bacteria	2|Bacteria	L	Phage endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Phage_endo_I
DTH3_k127_2482092_2	585423.KR49_06890	6.023e-51	187.0	2AIUU@1|root,319C0@2|Bacteria,1GH80@1117|Cyanobacteria,1H3NS@1129|Synechococcus	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_2482092_0	1121459.AQXE01000001_gene2774	3.49e-89	322.0	COG5108@1|root,COG5108@2|Bacteria,1PIWB@1224|Proteobacteria,42YXG@68525|delta/epsilon subdivisions,2WU1V@28221|Deltaproteobacteria,2M9ED@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	RNA_pol,RPOL_N
DTH3_k127_2482092_4	457398.HMPREF0326_02680	2.129e-11	67.0	COG0582@1|root,COG0582@2|Bacteria,1N45B@1224|Proteobacteria,42QTV@68525|delta/epsilon subdivisions,2WUDT@28221|Deltaproteobacteria,2MHBM@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
DTH3_k127_2560973_2	768706.Desor_0834	8.286e-50	184.0	COG0778@1|root,COG0778@2|Bacteria,1V9PC@1239|Firmicutes,24M6A@186801|Clostridia,266UE@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DTH3_k127_2560973_3	903814.ELI_3642	1.071e-37	151.0	COG2122@1|root,COG2122@2|Bacteria,1TQ6A@1239|Firmicutes,249KT@186801|Clostridia,25YHZ@186806|Eubacteriaceae	186801|Clostridia	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
DTH3_k127_2560973_4	224325.AF_1185	1.513e-27	117.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,246EW@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
DTH3_k127_2560973_0	1041930.Mtc_0355	9.702e-182	581.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
DTH3_k127_2560973_5	178306.PAE0463	7.452e-10	70.0	arCOG07689@1|root,arCOG07689@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_2560973_1	304371.MCP_0226	8.623e-54	194.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
DTH3_k127_2590050_0	555079.Toce_2133	1.106e-98	328.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
DTH3_k127_2590050_5	309799.DICTH_1604	1.185e-48	187.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH3_k127_2590050_3	1232437.KL662043_gene2211	7.674e-54	198.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,43BR3@68525|delta/epsilon subdivisions,2X720@28221|Deltaproteobacteria,2MK1P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
DTH3_k127_2590050_4	865861.AZSU01000001_gene549	2.924e-51	188.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24FZI@186801|Clostridia,36IEF@31979|Clostridiaceae	186801|Clostridia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
DTH3_k127_2590050_1	216596.pRL80025	9.012e-88	319.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,4BME9@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
DTH3_k127_2590050_2	767817.Desgi_0753	1.962e-70	251.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
DTH3_k127_2590050_6	269797.Mbar_A0578	3.287e-24	116.0	COG0348@1|root,arCOG02772@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
DTH3_k127_2700639_0	439481.Aboo_1160	1.584e-249	788.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,3F2JF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
DTH3_k127_2785726_0	410359.Pcal_2009	2.879e-80	280.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
DTH3_k127_2785726_1	309799.DICTH_1221	2.799e-25	109.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
DTH3_k127_284009_1	591019.Shell_1444	5.272e-73	253.0	COG0090@1|root,arCOG04067@2157|Archaea,2XPW8@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
DTH3_k127_284009_3	342949.PNA2_0380	1.65e-23	102.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
DTH3_k127_284009_0	1220534.B655_1959	1.587e-74	258.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
DTH3_k127_284009_2	523845.AQXV01000031_gene1139	3.717e-62	219.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,23QD1@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
DTH3_k127_2927440_1	936455.KI421499_gene4986	1.074e-20	104.0	COG0438@1|root,COG0438@2|Bacteria,1Q7RK@1224|Proteobacteria,2VDX3@28211|Alphaproteobacteria,3K4ZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_2927440_0	589924.Ferp_2404	1.197e-63	228.0	arCOG03850@1|root,arCOG03850@2157|Archaea,2XYUB@28890|Euryarchaeota	28890|Euryarchaeota	S	Cephalosporin hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
DTH3_k127_2927440_2	1121451.DESAM_22201	8.59e-07	55.0	COG0438@1|root,COG0438@2|Bacteria,1NF2Z@1224|Proteobacteria,42V61@68525|delta/epsilon subdivisions,2WS5P@28221|Deltaproteobacteria,2M8T0@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1
DTH3_k127_2955607_0	1229909.NSED_05285	3.993e-135	447.0	COG4962@1|root,arCOG01817@2157|Archaea,41T25@651137|Thaumarchaeota	651137|Thaumarchaeota	N	COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DTH3_k127_3004327_1	485913.Krac_2942	1.358e-52	190.0	COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DTH3_k127_3004327_2	523845.AQXV01000026_gene1469	1.879e-41	167.0	arCOG02545@1|root,arCOG02545@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
DTH3_k127_3004327_3	1232410.KI421413_gene576	2.012e-11	74.0	COG0655@1|root,COG0655@2|Bacteria,1RKK7@1224|Proteobacteria,42T1X@68525|delta/epsilon subdivisions,2WPCQ@28221|Deltaproteobacteria,43V03@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DTH3_k127_3004327_0	273063.STK_06230	1.671e-226	726.0	COG0308@1|root,arCOG02969@2157|Archaea,2XRK6@28889|Crenarchaeota	28889|Crenarchaeota	E	peptide catabolic process	ape2	-	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
DTH3_k127_3013648_9	192952.MM_0073	1.274e-53	196.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
DTH3_k127_3013648_2	693661.Arcve_0786	2.785e-144	468.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
DTH3_k127_3013648_1	368408.Tpen_0093	1.771e-155	506.0	COG0213@1|root,arCOG02013@2157|Archaea,2XPZT@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	-	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	CDC48_N,Glycos_trans_3N,Glycos_transf_3,PYNP_C
DTH3_k127_3013648_4	1343739.PAP_04815	5.106e-102	342.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2434J@183968|Thermococci	183968|Thermococci	J	Belongs to the eIF-2B alpha beta delta subunits family	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
DTH3_k127_3013648_7	387631.Asulf_01857	6.947e-60	224.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_3013648_13	272844.PAB1229	0.0007856	46.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y3PS@28890|Euryarchaeota,243P1@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DTH3_k127_3013648_0	1125863.JAFN01000001_gene1482	1.7e-249	779.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
DTH3_k127_3013648_3	247490.KSU1_D0929	7.805e-104	349.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	nirK	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,Cytochrom_C,Cytochrome_CBB3
DTH3_k127_3013648_6	523845.AQXV01000046_gene840	2.669e-64	235.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,23QRP@183939|Methanococci	183939|Methanococci	E	PFAM aminotransferase class V	-	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	-	-	-	-	-	-	-	-	-	Aminotran_5
DTH3_k127_3013648_10	1230343.CANP01000029_gene2243	2.295e-46	181.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,1RXJG@1236|Gammaproteobacteria,1JFMJ@118969|Legionellales	118969|Legionellales	M	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
DTH3_k127_3013648_11	1459636.NTE_00644	1.546e-26	115.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3013648_5	349124.Hhal_0116	7.308e-91	308.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
DTH3_k127_3013648_8	1220534.B655_2215	1.018e-54	205.0	COG1035@1|root,arCOG02651@2157|Archaea,2XUH6@28890|Euryarchaeota,23NWU@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit	frhB1	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N
DTH3_k127_3013648_12	679926.Mpet_0592	6.433e-07	61.0	COG1941@1|root,arCOG02473@2157|Archaea,2XUXH@28890|Euryarchaeota,2N9H2@224756|Methanomicrobia	224756|Methanomicrobia	C	NADH ubiquinone oxidoreductase 20 kDa subunit	frhG-1	-	1.12.98.1	ko:K00443	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Oxidored_q6
DTH3_k127_3045968_1	768706.Desor_4420	8.774e-06	49.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24CK1@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
DTH3_k127_3045968_0	368408.Tpen_0002	3.144e-133	434.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
DTH3_k127_3061603_0	1459636.NTE_00103	1.005e-78	276.0	COG0550@1|root,arCOG01527@2157|Archaea,41TBA@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	-
DTH3_k127_3061603_1	448385.sce8608	7.843e-74	264.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
DTH3_k127_3061603_2	588596.U9UBM1	1.129e-09	63.0	COG0463@1|root,KOG2978@2759|Eukaryota,38E12@33154|Opisthokonta,3NUQC@4751|Fungi	4751|Fungi	M	dolichol-phosphate mannosyltransferase	DPM1	GO:0000030,GO:0003674,GO:0003824,GO:0004582,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006488,GO:0006490,GO:0006493,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0031984,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0097502,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
DTH3_k127_3065255_0	604354.TSIB_1807	8.056e-158	513.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,2430Z@183968|Thermococci	183968|Thermococci	K	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
DTH3_k127_3065255_1	1128421.JAGA01000001_gene2396	1.537e-63	232.0	COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
DTH3_k127_3074059_0	340099.Teth39_0287	3.235e-127	419.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH3_k127_3074059_1	1499967.BAYZ01000171_gene5541	6.169e-104	347.0	COG2084@1|root,COG2084@2|Bacteria,2NQRW@2323|unclassified Bacteria	2|Bacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	iNRG857_1313.NRG857_15520	NAD_binding_11,NAD_binding_2
DTH3_k127_3074059_2	883078.HMPREF9695_03131	4.157e-48	184.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2TRWV@28211|Alphaproteobacteria,3JVAV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_3134581_13	273063.STK_04590	1.655e-25	108.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
DTH3_k127_3134581_0	1183377.Py04_1586	8.972e-149	482.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
DTH3_k127_3134581_1	1220534.B655_2454	3.434e-81	281.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
DTH3_k127_3134581_9	1365176.N186_03075	4.58e-41	157.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
DTH3_k127_3134581_6	868131.MSWAN_0315	7.543e-46	176.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
DTH3_k127_3134581_15	439481.Aboo_0130	1.098e-17	90.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,3F2SW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	PIN domain of ribonuclease	nob1	GO:0000469,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0030490,GO:0030684,GO:0030688,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1990904	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
DTH3_k127_3134581_3	186497.PF1862	1.528e-57	207.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,242KI@183968|Thermococci	183968|Thermococci	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
DTH3_k127_3134581_4	246969.TAM4_2323	6.794e-49	184.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,242SR@183968|Thermococci	183968|Thermococci	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
DTH3_k127_3134581_10	573063.Metin_0266	9.195e-37	148.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23QQD@183939|Methanococci	183939|Methanococci	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
DTH3_k127_3134581_8	523845.AQXV01000053_gene665	3.209e-44	166.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
DTH3_k127_3134581_2	877455.Metbo_0198	6.54e-69	246.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23NUP@183925|Methanobacteria	183925|Methanobacteria	J	Diphthamide	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
DTH3_k127_3134581_7	1183377.Py04_0367	2.011e-44	169.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
DTH3_k127_3134581_12	192952.MM_1879	3.657e-27	119.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,2N9T0@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
DTH3_k127_3134581_16	386456.JQKN01000012_gene988	7.626e-15	78.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
DTH3_k127_3134581_14	69014.TK1166	1.225e-19	94.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
DTH3_k127_3134581_5	679926.Mpet_1691	7.475e-48	178.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
DTH3_k127_3134581_11	453591.Igni_0852	2.84e-27	114.0	COG1594@1|root,arCOG00579@2157|Archaea,2XQQ6@28889|Crenarchaeota	28889|Crenarchaeota	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	tfs	GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
DTH3_k127_3135087_2	456442.Mboo_1370	4.927e-06	49.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,2N93F@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0200	CdhD
DTH3_k127_3135087_0	593750.Metfor_1717	6.932e-172	553.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
DTH3_k127_3135087_1	1229909.NSED_07320	1.296e-95	325.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
DTH3_k127_3140234_2	1459636.NTE_02727	1.449e-18	98.0	COG1630@1|root,arCOG00367@2157|Archaea	2157|Archaea	S	PFAM NurA domain	-	-	-	-	-	-	-	-	-	-	-	-	NurA
DTH3_k127_3140234_0	1459636.NTE_02728	1.279e-116	391.0	COG0433@1|root,arCOG00280@2157|Archaea	2157|Archaea	I	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
DTH3_k127_3140234_1	439481.Aboo_0831	2.271e-70	248.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,3F2KR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
DTH3_k127_3140234_3	1131266.ARWQ01000004_gene1491	7.156e-10	62.0	COG4919@1|root,arCOG04293@2157|Archaea,41SVI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
DTH3_k127_3140234_4	1392493.JIAB01000001_gene1664	0.0003405	46.0	2CEVT@1|root,32D74@2|Bacteria,1UDXG@1239|Firmicutes,25IRN@186801|Clostridia,27SKQ@186928|unclassified Lachnospiraceae	186801|Clostridia	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3167276_0	387631.Asulf_00417	4.288e-157	503.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,245NS@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
DTH3_k127_3167276_1	593117.TGAM_1921	8.721e-55	195.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,243D7@183968|Thermococci	183968|Thermococci	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
DTH3_k127_3167276_3	1123252.ATZF01000018_gene1635	0.0001115	53.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,4HWJ1@91061|Bacilli,27CIP@186824|Thermoactinomycetaceae	91061|Bacilli	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
DTH3_k127_3167276_2	192952.MM_1321	2.834e-29	119.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,2N97E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
DTH3_k127_3179551_8	1459636.NTE_01903	2.37e-24	108.0	COG3620@1|root,arCOG00608@2157|Archaea,41SJR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
DTH3_k127_3179551_7	215803.DB30_8850	9.918e-28	123.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,42UUC@68525|delta/epsilon subdivisions,2WQFQ@28221|Deltaproteobacteria,2YX9U@29|Myxococcales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DTH3_k127_3179551_9	368407.Memar_1123	2.387e-09	62.0	arCOG04002@1|root,arCOG04002@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405,IF2_N
DTH3_k127_3179551_1	768706.Desor_4420	1.05e-108	368.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24CK1@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
DTH3_k127_3179551_5	1089553.Tph_c27670	2.353e-59	212.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548,ko:K14084	ko00270,ko00450,ko00670,ko00680,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map01100,map01110,map01120,map01200,map01230	M00017,M00563	R00946,R09124,R09365	RC00035,RC00113,RC00732,RC01241,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
DTH3_k127_3179551_0	1265505.ATUG01000002_gene2462	1.921e-111	368.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2MPC0@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M19
DTH3_k127_3179551_3	589924.Ferp_1610	1.768e-83	291.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,246RQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
DTH3_k127_3179551_4	323259.Mhun_1311	7.612e-83	280.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota,2NBII@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH3_k127_3179551_6	693661.Arcve_0342	8.89e-49	180.0	COG4739@1|root,arCOG04483@2157|Archaea,2XYZT@28890|Euryarchaeota,24725@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148,FeS
DTH3_k127_3179551_2	589924.Ferp_1490	3.886e-92	313.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246RE@183980|Archaeoglobi	183980|Archaeoglobi	C	acetyl coenzyme A synthetase	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
DTH3_k127_3188690_2	436308.Nmar_0246	7.26e-16	78.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
DTH3_k127_3188690_3	401526.TcarDRAFT_2535	5.548e-06	51.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,4H2M1@909932|Negativicutes	909932|Negativicutes	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DTH3_k127_3188690_0	1163730.FFONT_0918	7.89e-89	309.0	COG0677@1|root,arCOG00252@2157|Archaea,2XQDG@28889|Crenarchaeota	28889|Crenarchaeota	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DTH3_k127_3188690_1	1459636.NTE_02312	4.576e-54	203.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
DTH3_k127_3210353_0	868131.MSWAN_1950	8.455e-79	279.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
DTH3_k127_3210353_1	221288.JH992901_gene3767	1.341e-35	148.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DTH3_k127_3255997_3	388467.A19Y_0119	1.554e-05	50.0	COG1977@1|root,COG1977@2|Bacteria,1G86C@1117|Cyanobacteria,1HC6T@1150|Oscillatoriales	1117|Cyanobacteria	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DTH3_k127_3255997_2	439235.Dalk_0703	2.664e-30	124.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,42TYZ@68525|delta/epsilon subdivisions,2WQSE@28221|Deltaproteobacteria,2MQ1Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
DTH3_k127_3255997_0	697303.Thewi_0375	5.342e-188	605.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH3_k127_3255997_1	593750.Metfor_1104	1.255e-112	365.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
DTH3_k127_326253_1	1365176.N186_07280	1.866e-42	165.0	COG0842@1|root,arCOG01467@2157|Archaea,2XQAJ@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DTH3_k127_326253_0	368408.Tpen_1222	1.57e-93	317.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPRD@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DTH3_k127_3306416_10	69014.TK1596	0.0001307	48.0	COG2811@1|root,arCOG03363@2157|Archaea,2Y4S2@28890|Euryarchaeota,245JU@183968|Thermococci	183968|Thermococci	C	H subunit	-	-	-	ko:K02107	ko00190,map00190	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V-ATPase_G_2
DTH3_k127_3306416_9	5111.M1W558	6.177e-05	53.0	COG1390@1|root,KOG1664@2759|Eukaryota,38FW0@33154|Opisthokonta,3NXSD@4751|Fungi,3QPPF@4890|Ascomycota,2139N@147550|Sordariomycetes,3TD6X@5125|Hypocreales,3FZPR@34397|Clavicipitaceae	4751|Fungi	C	ATP synthase (E/31 kDa) subunit	VMA4	GO:0000221,GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015988,GO:0015991,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016471,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0031090,GO:0031224,GO:0032991,GO:0033176,GO:0033178,GO:0033180,GO:0034220,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045851,GO:0046961,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0090662,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098796,GO:0098805,GO:0098852,GO:0099131,GO:0099132,GO:1902600	-	ko:K02150	ko00190,ko01100,ko04145,ko04150,ko04721,ko04966,ko05110,ko05120,ko05323,map00190,map01100,map04145,map04150,map04721,map04966,map05110,map05120,map05323	M00160	-	-	ko00000,ko00001,ko00002	3.A.2.2	-	-	vATP-synt_E
DTH3_k127_3306416_0	1343739.PAP_09425	4.201e-201	643.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3
DTH3_k127_3306416_1	368408.Tpen_0341	4.807e-195	618.0	COG1156@1|root,arCOG00865@2157|Archaea,2XPKW@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DTH3_k127_3306416_6	760011.Spico_0755	1.588e-14	81.0	COG1394@1|root,COG1394@2|Bacteria,2J5V1@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
DTH3_k127_3306416_5	373903.Hore_19450	6.382e-20	102.0	COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia	186801|Clostridia	C	Archaeal vacuolar-type H -ATPase subunit C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DTH3_k127_3306416_7	1499967.BAYZ01000009_gene5287	6.365e-13	74.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
DTH3_k127_3306416_3	1365176.N186_02695	1.463e-54	214.0	COG1269@1|root,arCOG04138@2157|Archaea,2XQ7V@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DTH3_k127_3306416_8	529709.PYCH_06310	1.297e-07	59.0	COG0440@1|root,arCOG00811@2157|Archaea,2XY7D@28890|Euryarchaeota,2449W@183968|Thermococci	183968|Thermococci	E	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DTH3_k127_3306416_2	546271.Selsp_1453	1.292e-57	207.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H408@909932|Negativicutes	909932|Negativicutes	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
DTH3_k127_3306416_4	1382359.JIAL01000001_gene418	5.146e-21	98.0	COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria,2JJWU@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DTH3_k127_332236_1	368408.Tpen_1817	2.505e-97	322.0	COG2414@1|root,arCOG00706@2157|Archaea,2XPT1@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH3_k127_332236_4	667014.Thein_2107	1.898e-49	181.0	COG0437@1|root,COG0437@2|Bacteria,2GIJ6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DTH3_k127_332236_9	70601.3257171	9.761e-10	65.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,243ZZ@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator	tfx	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
DTH3_k127_332236_0	591019.Shell_1559	7.268e-196	625.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPYR@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsB	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
DTH3_k127_332236_10	234267.Acid_7022	4.132e-07	64.0	COG5555@1|root,COG5555@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DTH3_k127_332236_6	374847.Kcr_0936	1.669e-26	128.0	arCOG08038@1|root,arCOG08038@2157|Archaea	2157|Archaea	S	protein secretion by the type IV secretion system	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_332236_3	697303.Thewi_2114	4.055e-53	194.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
DTH3_k127_332236_2	1232453.BAIF02000027_gene4189	2.993e-61	227.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24BVD@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH3_k127_332236_11	877455.Metbo_1600	1.815e-06	61.0	arCOG02487@1|root,arCOG02555@1|root,arCOG03270@1|root,arCOG02487@2157|Archaea,arCOG02555@2157|Archaea,arCOG03270@2157|Archaea,2Y7UE@28890|Euryarchaeota,23PA5@183925|Methanobacteria	183925|Methanobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
DTH3_k127_332236_5	530564.Psta_4146	5.455e-31	137.0	COG0476@1|root,COG0476@2|Bacteria,2IY9K@203682|Planctomycetes	203682|Planctomycetes	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
DTH3_k127_332236_8	162425.CADANIAP00001467	1.611e-10	69.0	COG5078@1|root,KOG0423@2759|Eukaryota,38F8H@33154|Opisthokonta,3P325@4751|Fungi,3QUXJ@4890|Ascomycota,20C80@147545|Eurotiomycetes,3S4XP@5042|Eurotiales	4751|Fungi	O	Belongs to the ubiquitin-conjugating enzyme family	-	-	2.3.2.23	ko:K10583	ko04120,map04120	-	-	-	ko00000,ko00001,ko01000,ko04121	-	-	-	UQ_con
DTH3_k127_332236_7	1267534.KB906756_gene645	4.806e-20	102.0	COG1470@1|root,COG3391@1|root,COG4934@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,COG4934@2|Bacteria,3Y62V@57723|Acidobacteria,2JKVU@204432|Acidobacteriia	204432|Acidobacteriia	O	PFAM Peptidase S53, propeptide	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ
DTH3_k127_3323292_10	706587.Desti_0460	3.954e-09	59.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2X727@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
DTH3_k127_3323292_11	63737.Npun_R0694	1.147e-05	49.0	COG0631@1|root,COG0631@2|Bacteria,1FZZK@1117|Cyanobacteria,1HJGG@1161|Nostocales	1117|Cyanobacteria	T	PFAM protein phosphatase 2C	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	DZR,PP2C_2
DTH3_k127_3323292_8	1448860.BBJO01000009_gene694	6.808e-13	81.0	COG2304@1|root,arCOG02902@2157|Archaea,2XZJD@28890|Euryarchaeota,23X73@183963|Halobacteria	183963|Halobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
DTH3_k127_3323292_1	1459636.NTE_02780	1.531e-89	310.0	COG1641@1|root,arCOG02701@2157|Archaea,41SDC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
DTH3_k127_3323292_12	697281.Mahau_1555	4.083e-05	55.0	2EIBY@1|root,33C3A@2|Bacteria,1VQ1V@1239|Firmicutes,24FGH@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3323292_0	913865.DOT_1406	5.742e-99	340.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,263IU@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
DTH3_k127_3323292_6	273068.TTE1310	7.115e-44	166.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,42GHZ@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05505	NUDIX
DTH3_k127_3323292_2	56780.SYN_00463	3.449e-89	300.0	COG0500@1|root,COG2226@2|Bacteria,1QU24@1224|Proteobacteria,43BNY@68525|delta/epsilon subdivisions,2X70A@28221|Deltaproteobacteria,2MRB0@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
DTH3_k127_3323292_4	387631.Asulf_01274	1.593e-67	233.0	COG1720@1|root,arCOG00761@2157|Archaea,2XY3D@28890|Euryarchaeota,246RS@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
DTH3_k127_3323292_3	1365176.N186_08845	7.669e-77	274.0	COG0531@1|root,arCOG00009@2157|Archaea,2XQNU@28889|Crenarchaeota	28889|Crenarchaeota	E	Spore germination protein	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
DTH3_k127_3323292_7	1121405.dsmv_3770	1.629e-40	154.0	COG1342@1|root,COG1342@2|Bacteria,1N80T@1224|Proteobacteria,42TAM@68525|delta/epsilon subdivisions,2WP9H@28221|Deltaproteobacteria,2MK4A@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function  DUF134	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
DTH3_k127_3323292_5	1262449.CP6013_2899	8.797e-58	212.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,36FI5@31979|Clostridiaceae	186801|Clostridia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.291,1.1.1.31	ko:K00020,ko:K19647	ko00280,ko00760,ko01100,ko01120,map00280,map00760,map01100,map01120	-	R05066,R07985	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
DTH3_k127_3323292_9	1365176.N186_05755	4.276e-12	71.0	COG1826@1|root,arCOG02694@2157|Archaea,2XRB5@28889|Crenarchaeota	28889|Crenarchaeota	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
DTH3_k127_3339568_0	558169.AGAV01000018_gene3462	1.794e-60	220.0	COG0388@1|root,COG0388@2|Bacteria,1TQR9@1239|Firmicutes,4HDUI@91061|Bacilli	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DTH3_k127_3339568_1	909663.KI867150_gene2911	2.881e-45	177.0	COG0006@1|root,COG0006@2|Bacteria,1QNPN@1224|Proteobacteria,431BA@68525|delta/epsilon subdivisions,2WW9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
DTH3_k127_3444794_0	368408.Tpen_0325	1.75e-285	900.0	COG0525@1|root,arCOG00808@2157|Archaea,2XPW9@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
DTH3_k127_3444794_8	439481.Aboo_0810	4.445e-64	230.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota,3F2JB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DTH3_k127_3444794_12	1131266.ARWQ01000006_gene246	4.797e-11	74.0	arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DTH3_k127_3444794_2	515635.Dtur_0921	1.461e-150	486.0	COG1812@1|root,COG1812@2|Bacteria	2|Bacteria	E	S-adenosylmethionine synthetase (AdoMet synthetase)	metK-2	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
DTH3_k127_3444794_9	1499967.BAYZ01000076_gene805	2.834e-40	155.0	2DS8H@1|root,32USH@2|Bacteria	2|Bacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
DTH3_k127_3444794_6	1379698.RBG1_1C00001G0892	4.779e-88	301.0	COG1062@1|root,COG1062@2|Bacteria	2|Bacteria	C	S-(hydroxymethyl)glutathione dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
DTH3_k127_3444794_7	706587.Desti_2480	1.563e-80	276.0	COG4912@1|root,COG4912@2|Bacteria,1RGVM@1224|Proteobacteria,42ZZV@68525|delta/epsilon subdivisions,2WVCM@28221|Deltaproteobacteria,2MRS8@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
DTH3_k127_3444794_4	304371.MCP_2481	7.412e-133	432.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
DTH3_k127_3444794_5	374847.Kcr_0400	3.728e-110	367.0	COG1759@1|root,arCOG04346@2157|Archaea	2157|Archaea	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
DTH3_k127_3444794_10	1220534.B655_1291	5.541e-40	154.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DTH3_k127_3444794_13	247156.NFA_51250	3.141e-06	53.0	COG0346@1|root,COG0346@2|Bacteria,2IG0S@201174|Actinobacteria,4G0ZN@85025|Nocardiaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
DTH3_k127_3444794_3	572546.Arcpr_1849	1.051e-139	456.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,246RP@183980|Archaeoglobi	183980|Archaeoglobi	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
DTH3_k127_3444794_1	1121405.dsmv_2802	4.151e-151	482.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MJ7T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
DTH3_k127_3444794_11	591019.Shell_1403	2.347e-25	112.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH3_k127_3491825_1	1343739.PAP_00375	1.371e-68	240.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7NF@28890|Euryarchaeota,242VD@183968|Thermococci	183968|Thermococci	G	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
DTH3_k127_3491825_2	387631.Asulf_00545	2.487e-66	233.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota,24708@183980|Archaeoglobi	183980|Archaeoglobi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
DTH3_k127_3491825_4	1408303.JNJJ01000056_gene1932	2.235e-18	100.0	COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,4HG0Q@91061|Bacilli,1ZBKR@1386|Bacillus	91061|Bacilli	P	COG0725 ABC-type molybdate transport system, periplasmic component	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
DTH3_k127_3491825_0	387631.Asulf_00546	3.889e-74	272.0	COG2998@1|root,arCOG00229@2157|Archaea,2XUR9@28890|Euryarchaeota,246XU@183980|Archaeoglobi	183980|Archaeoglobi	P	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
DTH3_k127_3491825_3	123214.PERMA_1932	9.907e-21	97.0	COG2005@1|root,COG2005@2|Bacteria	2|Bacteria	P	Transcriptional regulator	modE	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	-	ko:K02019,ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000,ko03000	3.A.1.6.2,3.A.1.6.4	-	-	HTH_1,TOBE
DTH3_k127_3492888_1	573064.Mefer_1486	1.256e-20	96.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
DTH3_k127_3492888_0	1094980.Mpsy_1639	2.127e-115	381.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
DTH3_k127_3510224_4	368408.Tpen_0870	1.133e-08	61.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSEQ@28889|Crenarchaeota	28889|Crenarchaeota	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3510224_0	436308.Nmar_1428	6.453e-33	134.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
DTH3_k127_3510224_3	1220534.B655_0136	6.053e-09	64.0	COG1617@1|root,arCOG02197@2157|Archaea,2Y789@28890|Euryarchaeota,23P8E@183925|Methanobacteria	183925|Methanobacteria	S	Kinase binding protein CGI-121	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
DTH3_k127_3510224_1	399549.Msed_2121	8.991e-30	129.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
DTH3_k127_3510224_2	240292.Ava_4069	1.131e-17	92.0	COG1011@1|root,COG1011@2|Bacteria,1GAP5@1117|Cyanobacteria,1HQCC@1161|Nostocales	1117|Cyanobacteria	S	HAD-hyrolase-like	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH3_k127_3573105_3	1041930.Mtc_1790	6.901e-148	478.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
DTH3_k127_3573105_8	224325.AF_2298	2.624e-79	274.0	COG1467@1|root,arCOG04110@2157|Archaea,2Y7DK@28890|Euryarchaeota,246SV@183980|Archaeoglobi	183980|Archaeoglobi	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3573105_4	247490.KSU1_C1332	6.984e-145	466.0	COG1180@1|root,COG1180@2|Bacteria,2IYWA@203682|Planctomycetes	203682|Planctomycetes	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
DTH3_k127_3573105_15	933801.Ahos_1963	9.636e-10	63.0	COG1146@1|root,arCOG04548@2157|Archaea	2157|Archaea	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
DTH3_k127_3573105_10	192952.MM_0209	3.471e-52	189.0	COG1793@1|root,arCOG05256@2157|Archaea,2XY7Z@28890|Euryarchaeota,2N9V7@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA polymerase Ligase (LigD)	-	-	-	-	-	-	-	-	-	-	-	-	LigD_N
DTH3_k127_3573105_9	795359.TOPB45_0617	2.1e-78	267.0	COG0177@1|root,COG0177@2|Bacteria,2GH3R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
DTH3_k127_3573105_12	1094980.Mpsy_1303	1.563e-36	142.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DTH3_k127_3573105_7	768706.Desor_3968	9.916e-80	279.0	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,25CCC@186801|Clostridia,264Q5@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the peptidase M24B family	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
DTH3_k127_3573105_11	671065.MetMK1DRAFT_00021910	2.181e-38	153.0	COG1011@1|root,arCOG02291@2157|Archaea	2157|Archaea	S	hydrolase (HAD superfamily)	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH3_k127_3573105_13	568768.CM001975_gene1537	3.653e-22	106.0	COG0778@1|root,COG0778@2|Bacteria,1NIJ8@1224|Proteobacteria,1RMRT@1236|Gammaproteobacteria,2JBYT@204037|Dickeya	1236|Gammaproteobacteria	C	Nitroreductase family	nfsA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016651,GO:0016657,GO:0032553,GO:0034567,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.5.1.38	ko:K10678,ko:K19285	ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120	-	R05706,R08014,R08017,R08042	RC00126,RC00250	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
DTH3_k127_3573105_2	519442.Huta_1371	1.788e-153	496.0	COG0014@1|root,arCOG01253@2157|Archaea,2XU44@28890|Euryarchaeota,23U59@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DTH3_k127_3573105_6	1094980.Mpsy_1152	1.48e-122	403.0	COG0263@1|root,arCOG00864@2157|Archaea,2XV1I@28890|Euryarchaeota,2NAAX@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
DTH3_k127_3573105_5	304371.MCP_1164	1.784e-136	443.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,2NAB8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
DTH3_k127_3573105_14	1250278.JQNQ01000001_gene2559	1.099e-13	82.0	COG3408@1|root,COG3408@2|Bacteria,4NGZM@976|Bacteroidetes,1I02Y@117743|Flavobacteriia	976|Bacteroidetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100,S6PP
DTH3_k127_3573105_0	635013.TherJR_2732	0.0	1193.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
DTH3_k127_3573105_1	246194.CHY_0258	1.964e-195	621.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,42F1Y@68295|Thermoanaerobacterales	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
DTH3_k127_3608132_2	1284708.HMPREF1634_06555	1.109e-13	83.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3WCXH@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
DTH3_k127_3608132_1	584708.Apau_0522	1.977e-17	87.0	COG4696@1|root,COG4696@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	XK27_03185	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	Acetyltransf_3,Hydrolase_3,PRA-PH
DTH3_k127_3608132_3	546273.VEIDISOL_00707	5.406e-13	72.0	29XKP@1|root,30JBV@2|Bacteria,1U4VG@1239|Firmicutes,4H69V@909932|Negativicutes	909932|Negativicutes	S	Protein of unknwon function (DUF3310)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3310
DTH3_k127_3608132_0	160488.PP_2276	5.569e-22	99.0	COG0258@1|root,COG0258@2|Bacteria,1MYSI@1224|Proteobacteria,1SQ55@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	5'-3' exonuclease, N-terminal resolvase-like domain	-	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc_N
DTH3_k127_362215_2	529507.PMI3146	5.042e-30	121.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,1RW9F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,HTH_32,rve,rve_3
DTH3_k127_362215_0	1197906.CAJQ02000043_gene2017	1.963e-140	459.0	COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,2TVAN@28211|Alphaproteobacteria,3K5GG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
DTH3_k127_362215_1	520709.F985_04056	8.11e-83	283.0	COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,1RW9F@1236|Gammaproteobacteria,3NJTA@468|Moraxellaceae	1236|Gammaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,HTH_32,rve,rve_3
DTH3_k127_362215_3	42565.FP66_03700	4.851e-05	46.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,1XPZB@135619|Oceanospirillales	135619|Oceanospirillales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3626190_3	439235.Dalk_2440	1.26e-55	198.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42NS5@68525|delta/epsilon subdivisions,2WNQ5@28221|Deltaproteobacteria,2MJ7B@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
DTH3_k127_3626190_0	1499967.BAYZ01000119_gene3222	1.25e-169	543.0	COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria	2|Bacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DTH3_k127_3626190_2	1123229.AUBC01000010_gene3368	2.319e-68	246.0	COG1748@1|root,COG1748@2|Bacteria,1QXB2@1224|Proteobacteria	1224|Proteobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3626190_4	1151117.AJLF01000001_gene1091	1.086e-20	95.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
DTH3_k127_3626190_1	351160.RCIX2726	1.319e-141	471.0	COG1948@1|root,arCOG02284@2157|Archaea,2XT7B@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM Beta propeller domain	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Beta_propel,Inhibitor_I42
DTH3_k127_3626190_5	323259.Mhun_1458	1.581e-12	76.0	arCOG06510@1|root,arCOG06510@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
DTH3_k127_3630901_0	1365176.N186_02080	8.698e-121	404.0	COG5253@1|root,arCOG04169@2157|Archaea,2XPYG@28889|Crenarchaeota	28889|Crenarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
DTH3_k127_3630901_5	1459636.NTE_02792	6.615e-05	51.0	COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
DTH3_k127_3630901_2	694429.Pyrfu_1686	2.744e-38	150.0	COG1102@1|root,arCOG01037@2157|Archaea,2XQ8J@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
DTH3_k127_3630901_3	273057.SSO5763	2.981e-25	108.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
DTH3_k127_3630901_4	490899.DKAM_1147	2.129e-19	90.0	COG0130@1|root,arCOG00987@2157|Archaea,2XPWX@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
DTH3_k127_3630901_1	368408.Tpen_0461	2.244e-85	290.0	COG0130@1|root,arCOG00987@2157|Archaea,2XPWX@28889|Crenarchaeota	28889|Crenarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
DTH3_k127_3646697_0	1121342.AUCO01000002_gene824	3.042e-07	64.0	2CC4I@1|root,2Z8PZ@2|Bacteria,1TQTT@1239|Firmicutes,24AJ3@186801|Clostridia,36F6T@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3674281_8	579137.Metvu_0280	7.517e-33	134.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
DTH3_k127_3674281_0	338966.Ppro_3524	3.915e-111	370.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions,2WJ4E@28221|Deltaproteobacteria,43TGG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
DTH3_k127_3674281_4	246194.CHY_1831	1.313e-60	220.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,42JFJ@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
DTH3_k127_3674281_10	634956.Geoth_1883	2.512e-24	112.0	COG1143@1|root,COG1143@2|Bacteria,1UCGF@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S dicluster domain	-	-	-	ko:K12143	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_7
DTH3_k127_3674281_5	926569.ANT_22050	5.692e-49	183.0	COG3260@1|root,COG3260@2|Bacteria,2G8XX@200795|Chloroflexi	200795|Chloroflexi	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	echC	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
DTH3_k127_3674281_3	589924.Ferp_1683	2.604e-61	228.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_3674281_7	675635.Psed_3734	3.367e-48	184.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4E4VX@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH3_k127_3674281_6	1158318.ATXC01000001_gene306	2.206e-48	185.0	COG4177@1|root,COG4177@2|Bacteria,2G5A3@200783|Aquificae	200783|Aquificae	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH3_k127_3674281_2	374847.Kcr_0826	2.208e-70	245.0	COG0411@1|root,arCOG00926@2157|Archaea	2157|Archaea	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DTH3_k127_3674281_1	374847.Kcr_0825	3.703e-72	250.0	COG0410@1|root,arCOG00924@2157|Archaea	2157|Archaea	E	ABC-type branched-chain amino acid transport systems ATPase component	livF5	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DTH3_k127_3674281_9	1120985.AUMI01000021_gene2791	8.961e-32	130.0	COG1661@1|root,COG1661@2|Bacteria,1VIGP@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DUF296)	-	-	-	-	-	-	-	-	-	-	-	-	DUF296
DTH3_k127_3700405_1	1131266.ARWQ01000003_gene1564	2.206e-69	245.0	COG0463@1|root,arCOG00894@2157|Archaea,41T1Z@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH3_k127_3700405_0	368408.Tpen_1720	6.369e-83	284.0	COG1210@1|root,arCOG00665@2157|Archaea	2157|Archaea	M	PFAM Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DTH3_k127_3710306_4	682795.AciX8_2221	3.092e-37	158.0	COG3506@1|root,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1349,Peptidase_S8,fn3
DTH3_k127_3710306_6	633148.Tagg_1147	8e-17	89.0	COG1475@1|root,arCOG01875@2157|Archaea,2XR7V@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM ParB domain protein nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
DTH3_k127_3710306_2	415426.Hbut_1101	5.182e-53	196.0	COG1637@1|root,arCOG01304@2157|Archaea,2XQ7Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
DTH3_k127_3710306_7	1229909.NSED_00125	2.435e-13	72.0	COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
DTH3_k127_3710306_1	694429.Pyrfu_0799	1.056e-68	243.0	COG0478@1|root,arCOG01181@2157|Archaea,2XPM0@28889|Crenarchaeota	28889|Crenarchaeota	T	RIO-like serine threonine protein kinase fused to N-terminal HTH domain	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
DTH3_k127_3710306_5	768672.Desfe_0755	7.279e-32	134.0	COG4720@1|root,arCOG05752@2157|Archaea,2XQ9C@28889|Crenarchaeota	28889|Crenarchaeota	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
DTH3_k127_3710306_0	246194.CHY_0125	5.418e-194	619.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
DTH3_k127_3710306_3	572546.Arcpr_0484	1.066e-45	168.0	COG0104@1|root,arCOG04387@2157|Archaea,2XT59@28890|Euryarchaeota,245QH@183980|Archaeoglobi	183980|Archaeoglobi	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DTH3_k127_3728609_1	645991.Sgly_1017	1.081e-64	228.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,261IU@186807|Peptococcaceae	186801|Clostridia	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
DTH3_k127_3728609_3	1365176.N186_05125	3.207e-21	100.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3728609_4	1121451.DESAM_20790	1.536e-15	85.0	COG0546@1|root,COG0546@2|Bacteria,1N2ZG@1224|Proteobacteria,42TKG@68525|delta/epsilon subdivisions,2WQ3W@28221|Deltaproteobacteria,2MBDT@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DTH3_k127_3728609_2	374847.Kcr_1470	8.839e-46	181.0	COG1819@1|root,arCOG01393@2157|Archaea	2157|Archaea	CG	Glycosyltransferase 28 domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_trans_1_3
DTH3_k127_3728609_0	246969.TAM4_1600	9.644e-66	230.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
DTH3_k127_3733401_1	453591.Igni_0272	2.013e-16	83.0	COG1383@1|root,arCOG01885@2157|Archaea,2XR16@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
DTH3_k127_3733401_0	633148.Tagg_1147	5.739e-29	123.0	COG1475@1|root,arCOG01875@2157|Archaea,2XR7V@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM ParB domain protein nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
DTH3_k127_3812322_0	1365176.N186_02980	6.9e-110	373.0	COG0417@1|root,arCOG00328@2157|Archaea,2XPM8@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM DNA polymerase (pol2)	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
DTH3_k127_3812322_2	573063.Metin_1263	6.443e-22	103.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,23QXI@183939|Methanococci	183939|Methanococci	K	PFAM GCN5-related N-acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DTH3_k127_3812322_1	1459636.NTE_02936	3.783e-53	192.0	COG0100@1|root,arCOG04240@2157|Archaea,41SII@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
DTH3_k127_3844361_2	436308.Nmar_1322	1.073e-18	90.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
DTH3_k127_3844361_1	1121035.AUCH01000012_gene3023	1.034e-23	112.0	COG0501@1|root,COG0501@2|Bacteria,1NG7Y@1224|Proteobacteria	1224|Proteobacteria	E	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
DTH3_k127_3844361_0	1268072.PSAB_13605	1.083e-74	261.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,270SS@186822|Paenibacillaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
DTH3_k127_3858186_7	1160137.KB907307_gene1402	1.231e-39	157.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria,4G0CR@85025|Nocardiaceae	201174|Actinobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
DTH3_k127_3858186_0	436308.Nmar_0067	5.763e-266	848.0	COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
DTH3_k127_3858186_12	1229909.NSED_07725	3.957e-11	69.0	arCOG01841@1|root,arCOG01841@2157|Archaea,41SPP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3858186_10	985053.VMUT_2051	3.239e-26	111.0	COG1324@1|root,arCOG04231@2157|Archaea,2XR9J@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
DTH3_k127_3858186_11	547559.Nmag_1532	6.547e-16	83.0	COG1310@1|root,arCOG01138@2157|Archaea,2XXA9@28890|Euryarchaeota,23VWD@183963|Halobacteria	183963|Halobacteria	S	metal-dependent protease of the PAD1 JAB1 superfamily	jamm1	-	3.4.19.15	ko:K20110	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Prok-JAB
DTH3_k127_3858186_5	1459636.NTE_00019	1.527e-56	215.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
DTH3_k127_3858186_13	416348.Hlac_3545	1.162e-08	67.0	COG0517@1|root,arCOG00601@2157|Archaea,2XVRW@28890|Euryarchaeota,23S35@183963|Halobacteria	183963|Halobacteria	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_3858186_2	1281779.H009_16621	8.481e-71	253.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,4BAI9@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	potA-1	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
DTH3_k127_3858186_3	351160.RCIX1623	4.102e-69	243.0	COG0555@1|root,arCOG00164@2157|Archaea,2XVJ4@28890|Euryarchaeota,2N9S1@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
DTH3_k127_3858186_8	351160.RCIX1621	1.442e-39	158.0	COG0725@1|root,arCOG00219@2157|Archaea,2XWT8@28890|Euryarchaeota,2N9WQ@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
DTH3_k127_3858186_4	374847.Kcr_0043	2.036e-58	214.0	COG0611@1|root,arCOG00638@2157|Archaea	2157|Archaea	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DTH3_k127_3858186_1	374847.Kcr_0960	4.583e-71	247.0	COG0013@1|root,arCOG01254@2157|Archaea	2157|Archaea	J	Related to alanyl-tRNA synthetase HxxxH domain	alaXM	GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2092	tRNA-synt_2c,tRNA_SAD
DTH3_k127_3858186_9	1459636.NTE_01018	1.085e-34	135.0	COG3432@1|root,arCOG01063@2157|Archaea,41T7S@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
DTH3_k127_3858186_6	374847.Kcr_0825	1.122e-47	174.0	COG0410@1|root,arCOG00924@2157|Archaea	2157|Archaea	E	ABC-type branched-chain amino acid transport systems ATPase component	livF5	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DTH3_k127_3868121_8	873517.HMPREF1977_0237	0.0007057	48.0	COG4319@1|root,COG4319@2|Bacteria,4NTW4@976|Bacteroidetes,1I4CG@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
DTH3_k127_3868121_5	933801.Ahos_0533	2.285e-23	102.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
DTH3_k127_3868121_6	1365176.N186_04575	8.435e-18	87.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
DTH3_k127_3868121_4	237368.SCABRO_00982	7.387e-34	140.0	COG2014@1|root,COG2014@2|Bacteria	2|Bacteria	F	Putative heavy-metal chelation	-	-	-	ko:K09138	-	-	-	-	ko00000	-	-	-	DUF364,DUF4213
DTH3_k127_3868121_2	1459636.NTE_01556	7.95e-67	233.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH3_k127_3868121_7	471854.Dfer_0576	6.342e-15	85.0	COG0454@1|root,COG0456@2|Bacteria,4NT7Q@976|Bacteroidetes,47VTT@768503|Cytophagia	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DTH3_k127_3868121_3	589924.Ferp_0844	2.811e-59	229.0	COG1138@1|root,arCOG06807@1|root,arCOG00270@2157|Archaea,arCOG06807@2157|Archaea,2XUDS@28890|Euryarchaeota,245X5@183980|Archaeoglobi	183980|Archaeoglobi	O	c-type cytochrome biogenesis protein CcmF	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
DTH3_k127_3868121_0	234267.Acid_1940	2.315e-140	454.0	COG3386@1|root,COG3386@2|Bacteria,3Y6YH@57723|Acidobacteria	57723|Acidobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
DTH3_k127_3868121_1	593750.Metfor_1453	2.992e-81	276.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	-	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
DTH3_k127_3868942_7	1237149.C900_02118	1.143e-31	135.0	COG1266@1|root,COG1266@2|Bacteria,4NVAP@976|Bacteroidetes,47SVF@768503|Cytophagia	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DTH3_k127_3868942_8	644968.DFW101_3710	1.017e-25	121.0	COG2006@1|root,COG2006@2|Bacteria,1N7GG@1224|Proteobacteria,42VMY@68525|delta/epsilon subdivisions,2WRZG@28221|Deltaproteobacteria,2M964@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
DTH3_k127_3868942_3	909663.KI867150_gene1492	7.274e-73	254.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2MRWV@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Bacitracin resistance protein BacA	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
DTH3_k127_3868942_11	1459636.NTE_02126	1.682e-11	74.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
DTH3_k127_3868942_4	268739.Nmlp_2863	2.127e-55	209.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,23SNU@183963|Halobacteria	183963|Halobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
DTH3_k127_3868942_2	521011.Mpal_0788	5.306e-73	250.0	COG1704@1|root,arCOG04574@2157|Archaea,2XX6E@28890|Euryarchaeota,2N9YK@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DTH3_k127_3868942_1	521011.Mpal_0789	6.779e-135	450.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,2NA0A@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
DTH3_k127_3868942_9	221360.RS9917_03533	4.331e-24	117.0	COG1215@1|root,COG1215@2|Bacteria,1G3BH@1117|Cyanobacteria,1GZ24@1129|Synechococcus	1117|Cyanobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
DTH3_k127_3868942_10	761193.Runsl_0031	5.28e-14	80.0	COG0463@1|root,COG0560@1|root,COG0463@2|Bacteria,COG0560@2|Bacteria,4NHAG@976|Bacteroidetes,47RYN@768503|Cytophagia	976|Bacteroidetes	EM	Putative Phosphatase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	ACT_6,HAD
DTH3_k127_3868942_6	1041930.Mtc_1078	4.881e-44	175.0	COG0438@1|root,arCOG01410@2157|Archaea,2Y8CA@28890|Euryarchaeota,2NBP9@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DTH3_k127_3868942_5	1459636.NTE_02630	3.112e-46	171.0	COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
DTH3_k127_3868942_0	693661.Arcve_1684	3.82e-158	505.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,245NJ@183980|Archaeoglobi	183980|Archaeoglobi	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DTH3_k127_3963100_9	436308.Nmar_0581	9.762e-22	97.0	COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
DTH3_k127_3963100_1	1499967.BAYZ01000038_gene2261	1.374e-108	355.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
DTH3_k127_3963100_10	1123234.AUKI01000015_gene2271	4.359e-11	64.0	2DH32@1|root,2ZY7U@2|Bacteria,4NVQB@976|Bacteroidetes,1I56B@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3963100_4	368408.Tpen_1050	2.833e-46	176.0	arCOG09435@1|root,arCOG09435@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_3963100_2	877455.Metbo_0069	1.458e-68	248.0	COG4012@1|root,arCOG04365@2157|Archaea,2XUWU@28890|Euryarchaeota,23PCC@183925|Methanobacteria	183925|Methanobacteria	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
DTH3_k127_3963100_7	289376.THEYE_A1926	2.698e-31	127.0	COG3118@1|root,COG3118@2|Bacteria,3J0P6@40117|Nitrospirae	40117|Nitrospirae	O	Thioredoxin-like domain	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DTH3_k127_3963100_11	387631.Asulf_02068	2.954e-07	61.0	COG1378@1|root,arCOG02038@2157|Archaea	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
DTH3_k127_3963100_8	522772.Dacet_2045	3.68e-22	102.0	COG1833@1|root,COG1833@2|Bacteria,2GGIN@200930|Deferribacteres	200930|Deferribacteres	S	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
DTH3_k127_3963100_3	1184251.TCELL_0842	4.257e-62	230.0	COG1109@1|root,COG1208@1|root,arCOG00666@2157|Archaea,arCOG00767@2157|Archaea,2XRVU@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
DTH3_k127_3963100_0	694429.Pyrfu_1421	3.427e-128	424.0	COG1109@1|root,arCOG00767@2157|Archaea,2XPXR@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DTH3_k127_3963100_6	374847.Kcr_1445	6.116e-33	139.0	COG0472@1|root,arCOG03199@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
DTH3_k127_4032968_1	304371.MCP_0982	4.666e-07	62.0	COG2319@1|root,arCOG02491@2157|Archaea,2Y226@28890|Euryarchaeota,2NB3Y@224756|Methanomicrobia	224756|Methanomicrobia	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
DTH3_k127_4032968_0	1459636.NTE_00871	4.151e-66	233.0	COG1801@1|root,arCOG04291@2157|Archaea,41T6J@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
DTH3_k127_403710_4	1123487.KB892840_gene57	9.515e-28	118.0	COG0651@1|root,COG1008@1|root,COG0651@2|Bacteria,COG1008@2|Bacteria,1QU5Z@1224|Proteobacteria,2VPQP@28216|Betaproteobacteria,2KYXK@206389|Rhodocyclales	206389|Rhodocyclales	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
DTH3_k127_403710_3	1183377.Py04_0975	1.383e-28	121.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0IM@28890|Euryarchaeota,2448E@183968|Thermococci	183968|Thermococci	O	Hydrogenase maturation protease	-	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
DTH3_k127_403710_2	570952.ATVH01000011_gene104	1.343e-32	134.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,2JPR6@204441|Rhodospirillales	204441|Rhodospirillales	H	Probable molybdopterin binding domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
DTH3_k127_403710_1	641107.CDLVIII_1029	7.462e-72	252.0	COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,36E0K@31979|Clostridiaceae	186801|Clostridia	S	Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3
DTH3_k127_403710_0	370438.PTH_1550	1.715e-102	343.0	COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,263EU@186807|Peptococcaceae	186801|Clostridia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
DTH3_k127_4044502_1	342949.PNA2_0186	4.881e-25	108.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,244AW@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
DTH3_k127_4044502_0	415426.Hbut_1592	3.706e-60	215.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
DTH3_k127_4044502_2	1131266.ARWQ01000001_gene1084	2.137e-15	81.0	arCOG05529@1|root,arCOG05529@2157|Archaea,41SSJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	dsDNA_bind
DTH3_k127_4067586_1	485916.Dtox_0814	2.67e-100	338.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,2603F@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
DTH3_k127_4067586_4	269799.Gmet_2233	1.597e-30	132.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,42R8E@68525|delta/epsilon subdivisions,2WN6V@28221|Deltaproteobacteria,43TY5@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH3_k127_4067586_6	693661.Arcve_0343	7.532e-27	126.0	COG0607@1|root,arCOG02021@2157|Archaea,2XY1R@28890|Euryarchaeota,246BX@183980|Archaeoglobi	183980|Archaeoglobi	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
DTH3_k127_4067586_3	386456.JQKN01000012_gene1046	2.344e-35	141.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DTH3_k127_4067586_0	1304284.L21TH_1732	2.846e-132	436.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,36DQZ@31979|Clostridiaceae	186801|Clostridia	J	metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
DTH3_k127_4067586_5	177437.HRM2_10530	1.784e-28	119.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MK26@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
DTH3_k127_4067586_2	926692.AZYG01000040_gene1505	8.317e-55	219.0	COG0507@1|root,COG1112@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,1TR8E@1239|Firmicutes,24B4D@186801|Clostridia,3WACJ@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DbpA
DTH3_k127_4067586_8	1382306.JNIM01000001_gene3928	3.2e-16	87.0	COG0420@1|root,COG0420@2|Bacteria,2G60M@200795|Chloroflexi	200795|Chloroflexi	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
DTH3_k127_4078631_1	342949.PNA2_0706	8.031e-35	142.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DTH3_k127_4078631_3	192952.MM_2919	9.198e-27	112.0	COG0599@1|root,arCOG02151@2157|Archaea,2Y0W0@28890|Euryarchaeota,2NB47@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
DTH3_k127_4078631_2	693661.Arcve_0808	2.133e-32	138.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,245QK@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
DTH3_k127_4078631_5	1123023.JIAI01000003_gene2633	3.902e-07	61.0	COG2141@1|root,COG2141@2|Bacteria,2HFD0@201174|Actinobacteria,4EBDZ@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DTH3_k127_4078631_0	694429.Pyrfu_1064	7.068e-47	186.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_4078631_6	880073.Calab_2318	3.804e-05	53.0	COG0500@1|root,COG2226@2|Bacteria,2NR2G@2323|unclassified Bacteria	2|Bacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
DTH3_k127_4078631_4	234267.Acid_6287	1.277e-17	94.0	COG1404@1|root,COG1470@1|root,COG3506@1|root,COG1404@2|Bacteria,COG1470@2|Bacteria,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	-	-	-	-	-	-	-	-	-	-	-	-	ASH,DUF11,DUF1349,Peptidase_S8,fn3
DTH3_k127_4088716_1	304371.MCP_1411	3.868e-33	133.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
DTH3_k127_4088716_0	374847.Kcr_1603	2.181e-132	438.0	COG0016@1|root,arCOG00410@2157|Archaea	2157|Archaea	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
DTH3_k127_4088716_2	387631.Asulf_00452	1.726e-14	75.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
DTH3_k127_4128611_2	118161.KB235919_gene6110	9.916e-42	167.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DTH3_k127_4128611_3	1396141.BATP01000003_gene4975	5.791e-08	66.0	COG1361@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,46WJ7@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
DTH3_k127_4128611_0	665952.HMPREF1015_02918	1.655e-182	586.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,4HDD6@91061|Bacilli,1ZD48@1386|Bacillus	91061|Bacilli	Q	multicopper oxidases	cotA	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
DTH3_k127_4128611_1	521011.Mpal_1668	2.799e-53	194.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
DTH3_k127_4228577_7	572546.Arcpr_0239	5.554e-30	122.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,24658@183980|Archaeoglobi	183980|Archaeoglobi	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
DTH3_k127_4228577_9	930945.SiRe_1648	6.695e-25	107.0	COG2118@1|root,arCOG04179@2157|Archaea,2XQYZ@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the PDCD5 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
DTH3_k127_4228577_12	342949.PNA2_1157	1.013e-10	64.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota,244NC@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
DTH3_k127_4228577_10	1220534.B655_1851	7.981e-18	87.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23P8C@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the ribosomal protein L31e family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
DTH3_k127_4228577_2	224325.AF_1199	4.575e-84	290.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
DTH3_k127_4228577_1	944480.ATUV01000001_gene603	5.011e-89	301.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2M734@213113|Desulfurellales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
DTH3_k127_4228577_0	1183377.Py04_1720	5.215e-104	355.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
DTH3_k127_4228577_11	1041930.Mtc_1091	4.601e-17	81.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
DTH3_k127_4228577_3	246194.CHY_0702	3.849e-83	282.0	COG1878@1|root,COG1878@2|Bacteria,1UZ93@1239|Firmicutes,25CZD@186801|Clostridia	186801|Clostridia	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DTH3_k127_4228577_8	536227.CcarbDRAFT_4097	3.314e-27	125.0	COG0348@1|root,COG0348@2|Bacteria,1VVUA@1239|Firmicutes,24C27@186801|Clostridia,36FBA@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_5
DTH3_k127_4228577_5	767817.Desgi_0753	3.644e-59	215.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
DTH3_k127_4228577_4	1232443.BAIA02000071_gene559	3.261e-78	290.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,26828@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
DTH3_k127_4228577_6	1125863.JAFN01000001_gene1570	1.68e-44	171.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42S8R@68525|delta/epsilon subdivisions,2WNW6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
DTH3_k127_4228577_13	68170.KL590472_gene6600	0.0006611	48.0	COG3631@1|root,COG3631@2|Bacteria,2II1M@201174|Actinobacteria,4EF08@85010|Pseudonocardiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
DTH3_k127_429692_0	525904.Tter_0300	1.251e-46	174.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DTH3_k127_429692_1	255470.cbdbA646	1.457e-40	164.0	COG4585@1|root,COG4585@2|Bacteria,2G8PE@200795|Chloroflexi,34CQA@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
DTH3_k127_429692_2	56780.SYN_01193	2.662e-13	72.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1R45R@1224|Proteobacteria,42MDG@68525|delta/epsilon subdivisions,2WKTC@28221|Deltaproteobacteria,2MQTM@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_4304510_1	42256.RradSPS_0871	1.007e-79	273.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
DTH3_k127_4304510_2	1125973.JNLC01000011_gene655	4.714e-69	246.0	COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2TUEU@28211|Alphaproteobacteria,3JU0Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	-	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
DTH3_k127_4304510_0	1229909.NSED_05405	4.744e-243	777.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
DTH3_k127_432011_1	1457250.BBMO01000002_gene2540	1.497e-59	227.0	COG1199@1|root,arCOG00770@2157|Archaea,2XSWZ@28890|Euryarchaeota,23S1B@183963|Halobacteria	183963|Halobacteria	K	COG1199 Rad3-related DNA helicases	-	-	-	-	-	-	-	-	-	-	-	-	DEAD_2,Helicase_C_2
DTH3_k127_432011_0	706587.Desti_1702	4.905e-75	256.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,42U4J@68525|delta/epsilon subdivisions,2WQ0R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
DTH3_k127_4331841_6	911008.GLAD_02810	1.698e-85	295.0	COG2220@1|root,COG2220@2|Bacteria,1N50Z@1224|Proteobacteria,1RRU3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions	ulaG	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	iYL1228.KPN_04585	Lactamase_B_2,Lactamase_B_3
DTH3_k127_4331841_17	1459636.NTE_01676	1.859e-33	142.0	arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_4331841_12	1121374.KB891575_gene861	8.154e-47	172.0	COG3193@1|root,COG3193@2|Bacteria,1RB2H@1224|Proteobacteria,1S5K1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein possibly involved in utilization of glycolate and propanediol	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
DTH3_k127_4331841_9	1220534.B655_1477	1.272e-61	221.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,23NZ9@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
DTH3_k127_4331841_18	323259.Mhun_2898	3.173e-29	121.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2N9UH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
DTH3_k127_4331841_20	673860.AciM339_1029	4.181e-21	98.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,3F2SC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
DTH3_k127_4331841_16	877455.Metbo_0811	1.119e-35	140.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
DTH3_k127_4331841_19	1365176.N186_02290	2.671e-26	109.0	COG1644@1|root,arCOG04244@2157|Archaea,2XR60@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
DTH3_k127_4331841_1	634498.mru_0914	2.141e-116	387.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23NP2@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DTH3_k127_4331841_8	591019.Shell_1647	9.859e-72	248.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
DTH3_k127_4331841_5	694429.Pyrfu_0913	7.727e-86	292.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
DTH3_k127_4331841_10	1365176.N186_05790	5.751e-53	199.0	COG1577@1|root,arCOG01028@2157|Archaea,2XQ8U@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
DTH3_k127_4331841_4	868131.MSWAN_1425	1.119e-103	349.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
DTH3_k127_4331841_0	1041930.Mtc_0274	9.284e-176	559.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota	28890|Euryarchaeota	I	Belongs to the HMG-CoA reductase family	hmgA-1	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
DTH3_k127_4331841_14	1056495.Calag_0209	3.057e-44	172.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQNM@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
DTH3_k127_4331841_7	272844.PAB0735	2.742e-74	257.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
DTH3_k127_4331841_15	1220534.B655_2010	1.021e-41	174.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23NN7@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
DTH3_k127_4331841_2	523850.TON_1047	2.589e-108	361.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,243PT@183968|Thermococci	183968|Thermococci	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
DTH3_k127_4331841_21	1045009.AFXQ01000001_gene2327	3.565e-08	57.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,1W9QU@1268|Micrococcaceae	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
DTH3_k127_4331841_22	933801.Ahos_0782	5.842e-05	50.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
DTH3_k127_4331841_13	589924.Ferp_1277	2.929e-44	167.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,24673@183980|Archaeoglobi	183980|Archaeoglobi	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036222,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
DTH3_k127_4331841_11	529709.PYCH_18600	4.204e-50	185.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
DTH3_k127_4331841_3	1131266.ARWQ01000001_gene1205	4.035e-106	354.0	COG0533@1|root,arCOG01183@2157|Archaea,41SDX@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37	kae1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
DTH3_k127_4402090_0	706587.Desti_4075	2.725e-83	285.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
DTH3_k127_4402090_1	1453503.AU05_08550	1.23e-05	52.0	COG0500@1|root,COG2226@2|Bacteria,1NJBJ@1224|Proteobacteria,1SZHB@1236|Gammaproteobacteria,1YDHS@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DTH3_k127_4435634_2	415426.Hbut_1089	1.058e-10	72.0	COG1340@1|root,arCOG01159@2157|Archaea,2XQW7@28889|Crenarchaeota	28889|Crenarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_4435634_0	436308.Nmar_1416	2.522e-86	292.0	COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
DTH3_k127_4435634_1	411489.CLOL250_00215	3.019e-20	93.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,36ECC@31979|Clostridiaceae	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DTH3_k127_4485961_11	439235.Dalk_0251	0.000729	44.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria,2MPWN@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
DTH3_k127_4485961_8	269797.Mbar_A0578	4.108e-29	131.0	COG0348@1|root,arCOG02772@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
DTH3_k127_4485961_9	1183377.Py04_0340	9.487e-25	110.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,243SX@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
DTH3_k127_4485961_0	986075.CathTA2_1446	4.634e-122	403.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HC4S@91061|Bacilli	91061|Bacilli	C	carnitine dehydratase	amacr	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
DTH3_k127_4485961_1	387631.Asulf_00867	1.175e-111	377.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246RE@183980|Archaeoglobi	183980|Archaeoglobi	C	acetyl coenzyme A synthetase	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
DTH3_k127_4485961_3	1343739.PAP_10190	2.5e-94	317.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243F9@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DTH3_k127_4485961_5	765177.Desmu_0799	1.187e-80	277.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DTH3_k127_4485961_2	580340.Tlie_0352	2.514e-99	349.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DTH3_k127_4485961_4	572547.Amico_1778	1.344e-85	294.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DTH3_k127_4485961_7	272844.PAB1195	6.511e-73	267.0	COG1173@1|root,arCOG00749@2157|Archaea,2Y86R@28890|Euryarchaeota,243AT@183968|Thermococci	183968|Thermococci	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DTH3_k127_4485961_6	592015.HMPREF1705_00648	1.758e-73	256.0	COG0095@1|root,COG0095@2|Bacteria,3TBDG@508458|Synergistetes	508458|Synergistetes	H	PFAM Biotin lipoate A B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
DTH3_k127_4485961_10	754252.PFREUD_10520	0.0005693	43.0	COG0095@1|root,COG0095@2|Bacteria,2GJV5@201174|Actinobacteria,4DP41@85009|Propionibacteriales	201174|Actinobacteria	H	Biotin/lipoate A/B protein ligase family	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
DTH3_k127_4566030_1	1131462.DCF50_p2384	6.641e-57	209.0	COG1600@1|root,COG1600@2|Bacteria,1V0B5@1239|Firmicutes,24FDD@186801|Clostridia,262G9@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM reductive dehalogenase	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4_16
DTH3_k127_4566030_3	289376.THEYE_A2013	4.639e-19	92.0	2E88U@1|root,332MT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_4566030_4	1250232.JQNJ01000001_gene3235	3.943e-15	83.0	COG5403@1|root,COG5403@2|Bacteria,4NEX0@976|Bacteroidetes,1HYHW@117743|Flavobacteriia	976|Bacteroidetes	S	PFAM Bacterial protein of	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
DTH3_k127_4566030_2	69014.TK1007	1.096e-34	148.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,245MW@183968|Thermococci	183968|Thermococci	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH3_k127_4566030_0	521011.Mpal_1530	2.706e-64	226.0	COG5423@1|root,arCOG04361@2157|Archaea,2Y00P@28890|Euryarchaeota,2N9Y9@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
DTH3_k127_4584680_4	70601.3256517	1.793e-08	58.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota,2436Y@183968|Thermococci	183968|Thermococci	P	ABC-type cobalt transport system, permease	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
DTH3_k127_4584680_2	666510.ASAC_0386	1.771e-33	139.0	COG1948@1|root,arCOG04206@2157|Archaea,2XQJU@28889|Crenarchaeota	28889|Crenarchaeota	L	ERCC4 domain protein	-	-	-	ko:K10848	ko03420,ko03460,map03420,map03460	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	ERCC4,HHH_5
DTH3_k127_4584680_0	399550.Smar_0385	1.836e-63	223.0	COG0794@1|root,arCOG00068@2157|Archaea,2XQ7R@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM sugar isomerase (SIS)	hxlB	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
DTH3_k127_4584680_1	529709.PYCH_00170	2.361e-56	204.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,242TE@183968|Thermococci	183968|Thermococci	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
DTH3_k127_4584680_3	1184251.TCELL_0419	9.06e-21	93.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DTH3_k127_4671022_4	56780.SYN_00305	8.451e-25	113.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MQFF@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
DTH3_k127_4671022_2	1089553.Tph_c23980	3.825e-34	140.0	COG0684@1|root,COG0684@2|Bacteria,1UZ9U@1239|Firmicutes,24ADH@186801|Clostridia,42G1P@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Dimethylmenaquinone methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
DTH3_k127_4671022_7	1123236.KB899386_gene1842	1.339e-08	65.0	COG0697@1|root,COG0697@2|Bacteria,1R4G2@1224|Proteobacteria,1S08Y@1236|Gammaproteobacteria,465ET@72275|Alteromonadaceae	1236|Gammaproteobacteria	EG	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DTH3_k127_4671022_1	96561.Dole_0563	1.483e-37	148.0	2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,2MNMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
DTH3_k127_4671022_3	648996.Theam_1284	2.035e-29	125.0	COG1611@1|root,COG1611@2|Bacteria,2G4BX@200783|Aquificae	200783|Aquificae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
DTH3_k127_4671022_0	192952.MM_0946	4.613e-72	247.0	COG1853@1|root,arCOG02016@2157|Archaea,2XYAJ@28890|Euryarchaeota,2N9RF@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DTH3_k127_4671022_6	255470.cbdbA1365	2.204e-13	83.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
DTH3_k127_4671022_5	243233.MCA2192	1.416e-22	111.0	COG4346@1|root,COG4346@2|Bacteria	2|Bacteria	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT,PMT_2,PMT_4TMC
DTH3_k127_4710502_4	555079.Toce_0156	2.212e-158	508.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,42EKQ@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
DTH3_k127_4710502_13	1459636.NTE_00733	2.339e-84	288.0	COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
DTH3_k127_4710502_21	1459636.NTE_01583	1.168e-14	76.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
DTH3_k127_4710502_19	1459636.NTE_00737	1.016e-37	146.0	COG1522@1|root,arCOG01580@2157|Archaea,41SNE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
DTH3_k127_4710502_22	436308.Nmar_1287	2.71e-11	66.0	arCOG01588@1|root,arCOG01588@2157|Archaea,41SVX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
DTH3_k127_4710502_11	1459636.NTE_01582	2.37e-89	302.0	COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
DTH3_k127_4710502_8	1131266.ARWQ01000004_gene1453	9.571e-133	431.0	COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DTH3_k127_4710502_14	1131266.ARWQ01000004_gene1454	1.338e-83	285.0	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
DTH3_k127_4710502_9	1459636.NTE_00736	1.191e-130	428.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH3_k127_4710502_12	1459636.NTE_01581	2.27e-88	304.0	COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine	lysK	-	-	ko:K05831	ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230	M00031,M00763	R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002	-	-	-	M20_dimer,Peptidase_M20
DTH3_k127_4710502_6	933801.Ahos_1431	2.124e-146	477.0	COG0119@1|root,arCOG02092@2157|Archaea,2XQ53@28889|Crenarchaeota	28889|Crenarchaeota	E	Homocitrate synthase	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	AsnC_trans_reg,HMGL-like
DTH3_k127_4710502_0	1459636.NTE_02178	1.182e-209	666.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DTH3_k127_4710502_17	386456.JQKN01000015_gene2928	3.179e-53	192.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,23P3W@183925|Methanobacteria	183925|Methanobacteria	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DTH3_k127_4710502_7	342949.PNA2_1345	6.921e-134	434.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,242YF@183968|Thermococci	183968|Thermococci	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
DTH3_k127_4710502_5	386456.JQKN01000008_gene1469	5.525e-149	484.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23NPF@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	aksD	-	4.2.1.114	ko:K16792	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
DTH3_k127_4710502_16	1304880.JAGB01000004_gene1484	6.111e-56	199.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
DTH3_k127_4710502_2	289376.THEYE_A0114	9.836e-178	562.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH3_k127_4710502_23	511062.GU3_06935	1.373e-08	58.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1T1N6@1236|Gammaproteobacteria,1Y53V@135624|Aeromonadales	135624|Aeromonadales	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH3_k127_4710502_1	1459636.NTE_02176	1.291e-188	601.0	COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DTH3_k127_4710502_3	1047013.AQSP01000140_gene2452	1.932e-163	521.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
DTH3_k127_4710502_18	1048983.EL17_10360	5.098e-47	178.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,4NERE@976|Bacteroidetes,47KYT@768503|Cytophagia	976|Bacteroidetes	E	Belongs to the PRA-CH family	hisI	-	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
DTH3_k127_4710502_10	579137.Metvu_0824	5.575e-102	339.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,23Q2Q@183939|Methanococci	183939|Methanococci	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DTH3_k127_4710502_15	644281.MFS40622_0754	1.595e-58	212.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,23QJK@183939|Methanococci	183939|Methanococci	E	TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DTH3_k127_4710502_20	859657.RPSI07_0551	8.15e-28	114.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,1K0YG@119060|Burkholderiaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DTH3_k127_4741747_1	323259.Mhun_1587	5.064e-10	64.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DTH3_k127_4741747_3	930945.SiRe_1557	4.313e-05	48.0	COG1996@1|root,arCOG04341@2157|Archaea	2157|Archaea	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
DTH3_k127_4741747_0	1056495.Calag_0487	7.346e-42	165.0	COG2520@1|root,arCOG00033@2157|Archaea,2XPMY@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
DTH3_k127_4741747_2	1365176.N186_02675	1.183e-06	53.0	arCOG07440@1|root,arCOG07440@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_4743246_0	1220534.B655_1721	1.926e-82	287.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
DTH3_k127_4743246_3	1365176.N186_06370	1.252e-33	137.0	COG1618@1|root,arCOG01034@2157|Archaea,2XR6D@28889|Crenarchaeota	28889|Crenarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
DTH3_k127_4743246_2	1183377.Py04_1540	2.689e-46	174.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
DTH3_k127_4743246_4	868131.MSWAN_1978	2.956e-08	61.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
DTH3_k127_4743246_1	694429.Pyrfu_0791	8.693e-55	196.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
DTH3_k127_4748120_2	368407.Memar_0776	4.1e-28	130.0	arCOG03383@1|root,arCOG03383@2157|Archaea,2Y7A4@28890|Euryarchaeota,2NB4Y@224756|Methanomicrobia	224756|Methanomicrobia	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DTH3_k127_4748120_0	1382358.JHVN01000002_gene2168	2.546e-65	231.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,21W76@150247|Anoxybacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
DTH3_k127_4748120_1	290315.Clim_2455	7.814e-56	212.0	COG4412@1|root,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	ina	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Peptidase_M6
DTH3_k127_4748120_3	368408.Tpen_0332	9.181e-06	51.0	arCOG03119@1|root,arCOG03119@2157|Archaea,2XQUD@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DTH3_k127_4763427_0	1123371.ATXH01000003_gene1893	5.257e-61	218.0	COG1926@1|root,COG1926@2|Bacteria	2|Bacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
DTH3_k127_4763427_4	134676.ACPL_6512	1.626e-28	129.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4DAJ5@85008|Micromonosporales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
DTH3_k127_4763427_1	1321778.HMPREF1982_02017	1.312e-56	208.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,26800@186813|unclassified Clostridiales	186801|Clostridia	T	Serine/threonine phosphatases, family 2C, catalytic domain	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
DTH3_k127_4763427_3	1382306.JNIM01000001_gene2771	4.496e-29	130.0	COG0515@1|root,COG1840@1|root,COG0515@2|Bacteria,COG1840@2|Bacteria,2G850@200795|Chloroflexi	2|Bacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11,SBP_bac_6
DTH3_k127_4763427_5	765420.OSCT_2679	1.22e-06	57.0	COG1716@1|root,COG1716@2|Bacteria,2GAM0@200795|Chloroflexi,376PS@32061|Chloroflexia	32061|Chloroflexia	T	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DZR,FHA
DTH3_k127_4763427_2	1448860.BBJO01000002_gene2128	8.091e-31	136.0	COG2304@1|root,arCOG02900@2157|Archaea,2XTZ0@28890|Euryarchaeota,23SRA@183963|Halobacteria	183963|Halobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
DTH3_k127_4763427_6	218284.CCDN010000001_gene445	0.0005313	51.0	COG4932@1|root,COG4932@2|Bacteria,1TQBI@1239|Firmicutes,4HBAT@91061|Bacilli,1ZD6Z@1386|Bacillus	91061|Bacilli	M	cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cna_B,Collagen_bind,Gram_pos_anchor,MucBP
DTH3_k127_4777592_5	525904.Tter_2722	6.164e-23	101.0	COG0640@1|root,COG0640@2|Bacteria,2NQ74@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
DTH3_k127_4777592_2	374847.Kcr_1538	1.122e-51	187.0	COG2210@1|root,arCOG02064@2157|Archaea	2157|Archaea	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
DTH3_k127_4777592_6	1408303.JNJJ01000016_gene213	3.167e-19	89.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,4HA11@91061|Bacilli,1ZATE@1386|Bacillus	91061|Bacilli	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
DTH3_k127_4777592_3	1449126.JQKL01000042_gene1027	6.287e-33	137.0	COG2181@1|root,COG2181@2|Bacteria,1V6BS@1239|Firmicutes,249A5@186801|Clostridia	186801|Clostridia	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
DTH3_k127_4777592_1	246194.CHY_2406	6.93e-100	342.0	COG0247@1|root,COG0247@2|Bacteria,1UZQ0@1239|Firmicutes,24E5H@186801|Clostridia,42F8Q@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17
DTH3_k127_4777592_7	1232410.KI421424_gene1760	1.789e-09	66.0	COG2010@1|root,COG2010@2|Bacteria,1QYFZ@1224|Proteobacteria,43CC3@68525|delta/epsilon subdivisions,2WQTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_4777592_4	314230.DSM3645_11122	1.055e-23	104.0	COG1917@1|root,COG1917@2|Bacteria,2J1N5@203682|Planctomycetes	203682|Planctomycetes	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_4777592_0	1459636.NTE_00800	3.141e-240	758.0	COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DTH3_k127_4779534_6	1220534.B655_1007	6.098e-82	289.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,23NKX@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the aspartokinase family	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
DTH3_k127_4779534_3	589924.Ferp_1128	4.818e-123	403.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,245UR@183980|Archaeoglobi	183980|Archaeoglobi	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DTH3_k127_4779534_5	573063.Metin_0016	3.606e-90	303.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,23QJD@183939|Methanococci	183939|Methanococci	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
DTH3_k127_4779534_7	573063.Metin_0931	8.111e-79	275.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,23QQQ@183939|Methanococci	183939|Methanococci	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
DTH3_k127_4779534_8	255470.cbdbA430	1.782e-34	141.0	COG0710@1|root,COG0710@2|Bacteria,2GBUG@200795|Chloroflexi,34CTN@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
DTH3_k127_4779534_4	203119.Cthe_3086	2.629e-116	389.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WG99@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
DTH3_k127_4779534_2	720554.Clocl_1829	3.615e-130	426.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,3WG94@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
DTH3_k127_4779534_10	1121396.KB893099_gene4285	1.62e-08	59.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2MIFU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
DTH3_k127_4779534_9	453591.Igni_0892	8.103e-28	124.0	COG0722@1|root,COG1605@1|root,arCOG00245@2157|Archaea,arCOG02098@2157|Archaea,2XQJX@28889|Crenarchaeota	28889|Crenarchaeota	E	chorismate mutase	tyrA	-	1.3.1.12,5.4.99.5	ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R01715,R01728	RC00125,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
DTH3_k127_4779534_0	694429.Pyrfu_0957	5.071e-200	641.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
DTH3_k127_4779534_1	694429.Pyrfu_0958	2.629e-133	437.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
DTH3_k127_4860233_1	204669.Acid345_1544	1.976e-44	178.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249,GO:0055114	5.4.99.9	ko:K01854,ko:K21779	ko00052,ko00333,ko00520,ko01130,map00052,map00333,map00520,map01130	M00837	R00505,R09009,R11661	RC00317,RC02396	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
DTH3_k127_4860233_0	304371.MCP_1161	4.541e-73	253.0	COG1018@1|root,arCOG02200@2157|Archaea,2XVD3@28890|Euryarchaeota,2N9JH@224756|Methanomicrobia	224756|Methanomicrobia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
DTH3_k127_486363_0	589924.Ferp_1735	1.821e-45	176.0	COG0269@1|root,arCOG00104@2157|Archaea	2157|Archaea	G	Formaldehyde-activating enzyme (Fae)	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
DTH3_k127_486363_1	1321782.HMPREF1986_01486	3.184e-10	71.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,2PQRI@265975|Oribacterium	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
DTH3_k127_4940412_0	1094980.Mpsy_2737	3.347e-187	593.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N95A@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
DTH3_k127_4940412_3	323259.Mhun_0330	4.659e-65	230.0	COG0411@1|root,arCOG00925@2157|Archaea,2XU75@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	livG-6	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DTH3_k127_4940412_2	1499967.BAYZ01000159_gene528	2.64e-72	250.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DTH3_k127_4940412_1	593750.Metfor_1700	1.969e-77	269.0	COG4177@1|root,arCOG01274@2157|Archaea,2XVR5@28890|Euryarchaeota	28890|Euryarchaeota	E	Branched-chain amino acid transport system permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH3_k127_4940412_4	593750.Metfor_1699	4.72e-27	111.0	COG0559@1|root,arCOG01270@2157|Archaea,2XUY9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0559 Branched-chain amino acid ABC-type transport system, permease components	livH5	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH3_k127_4973215_0	1183377.Py04_1145	3.867e-15	88.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,242NP@183968|Thermococci	183968|Thermococci	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
DTH3_k127_499560_4	374847.Kcr_0525	2.084e-23	102.0	COG0475@1|root,arCOG01953@2157|Archaea	2157|Archaea	P	Sodium hydrogen exchanger	napA	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
DTH3_k127_499560_2	644282.Deba_0147	1.162e-61	226.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WPU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
DTH3_k127_499560_7	1349820.M707_09050	7.265e-08	61.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_3,Flavodoxin_5
DTH3_k127_499560_5	1151119.KB895497_gene3408	7.601e-10	66.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DTH3_k127_499560_8	255470.cbdbA1147	3.464e-06	56.0	2A4HG@1|root,30T3R@2|Bacteria,2GAZU@200795|Chloroflexi,34DNN@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_499560_1	706587.Desti_2694	2.265e-125	410.0	COG0057@1|root,COG0057@2|Bacteria,1N2N1@1224|Proteobacteria	1224|Proteobacteria	G	Glyceraldehyde-3-phosphate dehydrogenase	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
DTH3_k127_499560_0	56780.SYN_02589	0.0	1655.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
DTH3_k127_499560_6	57918.XP_004298734.1	5.931e-09	61.0	COG2217@1|root,KOG0207@2759|Eukaryota,37HKS@33090|Viridiplantae,3G7MY@35493|Streptophyta,4JJ7G@91835|fabids	35493|Streptophyta	P	Copper-transporting ATPase	-	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0010035,GO:0010038,GO:0010273,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061687,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:0099132,GO:1990169	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DTH3_k127_499560_3	1459636.NTE_02696	1.908e-52	187.0	COG2217@1|root,COG3350@1|root,arCOG01576@2157|Archaea,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iAF692.Mbar_A1889	E1-E2_ATPase,HMA,Hydrolase,YHS
DTH3_k127_5004672_0	1094980.Mpsy_2704	2.099e-144	478.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
DTH3_k127_5004672_1	1183377.Py04_0766	1.334e-133	439.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
DTH3_k127_5004672_2	555088.DealDRAFT_1207	5.486e-07	57.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia	186801|Clostridia	E	Asparagine synthase, glutamine-hydrolyzing	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7,NAD_synthase
DTH3_k127_5037837_1	404589.Anae109_3519	9.183e-11	68.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
DTH3_k127_5037837_0	96561.Dole_2553	7.469e-120	391.0	COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,42TWC@68525|delta/epsilon subdivisions,2WQ80@28221|Deltaproteobacteria,2MMHB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
DTH3_k127_5061798_1	347834.RHE_CH00946	3.451e-89	304.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,4BBCA@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
DTH3_k127_5061798_0	795359.TOPB45_1251	1.53e-172	553.0	COG1350@1|root,COG1350@2|Bacteria,2GHCP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH3_k127_5061798_2	868131.MSWAN_0589	1.02e-38	151.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,23P42@183925|Methanobacteria	183925|Methanobacteria	K	regulator of amino acid metabolism, contains ACT domain	trpY	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
DTH3_k127_5063429_4	1131266.ARWQ01000005_gene818	4.032e-18	87.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
DTH3_k127_5063429_3	1054217.TALC_01282	2.761e-28	121.0	COG1945@1|root,arCOG04490@2157|Archaea	2157|Archaea	S	Pyruvoyl-dependent arginine decarboxylase	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2039	PvlArgDC
DTH3_k127_5063429_6	5762.XP_002674029.1	5.586e-11	67.0	COG5133@1|root,KOG3381@2759|Eukaryota	2759|Eukaryota	B	chromosome segregation	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0051186,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0106035,GO:1901564	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
DTH3_k127_5063429_2	273063.STK_04060	2.014e-33	134.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
DTH3_k127_5063429_0	391623.TERMP_00599	8.868e-197	624.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
DTH3_k127_5063429_1	1379698.RBG1_1C00001G1620	2.083e-49	191.0	COG2222@1|root,COG2222@2|Bacteria,2NQVV@2323|unclassified Bacteria	2|Bacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	pgi	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
DTH3_k127_5063429_5	634498.mru_0850	2.988e-15	78.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota,23NTH@183925|Methanobacteria	183925|Methanobacteria	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
DTH3_k127_5076505_0	272844.PAB2427	1.139e-107	362.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,242YE@183968|Thermococci	183968|Thermococci	J	Phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
DTH3_k127_5076505_2	323098.Nwi_0760	8.063e-31	127.0	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,2TVD8@28211|Alphaproteobacteria,3K5GX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
DTH3_k127_5076505_1	289376.THEYE_A1153	1.867e-50	181.0	COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
DTH3_k127_5097589_3	1089553.Tph_c08410	4.634e-34	136.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,42EXT@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
DTH3_k127_5097589_2	1459636.NTE_02630	7.328e-37	144.0	COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
DTH3_k127_5097589_1	269797.Mbar_A0624	5.254e-71	255.0	COG0119@1|root,arCOG02093@2157|Archaea,2XVVR@28890|Euryarchaeota,2N9C3@224756|Methanomicrobia	224756|Methanomicrobia	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
DTH3_k127_5097589_0	391623.TERMP_00777	6.212e-89	306.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,242QN@183968|Thermococci	183968|Thermococci	O	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
DTH3_k127_5097589_4	1267533.KB906734_gene3891	3.857e-15	81.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
DTH3_k127_5107419_1	1123489.AUAN01000009_gene285	9.159e-05	48.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,4H46W@909932|Negativicutes	909932|Negativicutes	G	Belongs to the phosphoglycerate mutase family	-	-	3.1.3.3	ko:K22305	ko00260,ko00680,ko01100,ko01120,ko01130,map00260,map00680,map01100,map01120,map01130	-	R00582	RC00017	ko00000,ko00001,ko01000	-	-	-	His_Phos_1
DTH3_k127_5107419_0	1125863.JAFN01000001_gene2345	3.464e-35	145.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,43CC6@68525|delta/epsilon subdivisions,2X7N2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
DTH3_k127_5115416_6	589924.Ferp_1125	3.624e-44	174.0	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,2461Y@183980|Archaeoglobi	183980|Archaeoglobi	P	Chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
DTH3_k127_5115416_12	1229909.NSED_03690	9.605e-24	105.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
DTH3_k127_5115416_3	269797.Mbar_A0560	3.353e-88	303.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NA7S@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	-	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
DTH3_k127_5115416_0	696281.Desru_1188	2.34e-150	484.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia	186801|Clostridia	C	domain protein	norV	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
DTH3_k127_5115416_2	660470.Theba_0060	3.411e-89	313.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DTH3_k127_5115416_17	869210.Marky_2134	1.22e-07	59.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
DTH3_k127_5115416_7	926569.ANT_26550	2.297e-39	156.0	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
DTH3_k127_5115416_8	1162668.LFE_1240	1.748e-36	144.0	COG1765@1|root,COG1765@2|Bacteria	1162668.LFE_1240|-	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5115416_19	593750.Metfor_2439	0.0002197	47.0	arCOG03911@1|root,arCOG03911@2157|Archaea	2157|Archaea	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
DTH3_k127_5115416_13	269797.Mbar_A1859	2.88e-21	97.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZVP@28890|Euryarchaeota,2NA27@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
DTH3_k127_5115416_16	1122129.AUEF01000010_gene1607	1.789e-11	76.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,4GWWE@90964|Staphylococcaceae	91061|Bacilli	EGP	Major facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DTH3_k127_5115416_18	399550.Smar_1074	6.916e-06	54.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
DTH3_k127_5115416_11	877455.Metbo_2019	1.03e-26	113.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
DTH3_k127_5115416_15	643648.Slip_1684	1.31e-12	71.0	2ED1S@1|root,336YP@2|Bacteria,1VJRI@1239|Firmicutes,24UCF@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5115416_4	1229909.NSED_01090	3.812e-84	295.0	COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
DTH3_k127_5115416_14	342949.PNA2_0910	4.595e-20	97.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,243N3@183968|Thermococci	183968|Thermococci	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
DTH3_k127_5115416_1	1459636.NTE_00969	2.037e-101	342.0	COG0182@1|root,arCOG01123@2157|Archaea,41SF9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
DTH3_k127_5115416_5	1183377.Py04_1582	4.081e-58	211.0	COG0503@1|root,arCOG00031@2157|Archaea,2XTD2@28890|Euryarchaeota,242RK@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	2.4.2.7	ko:K00759,ko:K09685	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko03000,ko04147	-	-	-	HTH_3,Pribosyltran
DTH3_k127_5115416_10	521011.Mpal_0292	8.583e-27	115.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y071@28890|Euryarchaeota	28890|Euryarchaeota	F	Deoxycytidine triphosphate deaminase	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
DTH3_k127_5115416_9	330214.NIDE3885	1.763e-27	115.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	ycaO	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	OsmC,YcaO
DTH3_k127_5117840_12	269797.Mbar_A2696	1.553e-08	57.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
DTH3_k127_5117840_4	485913.Krac_2085	2.672e-68	246.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
DTH3_k127_5117840_8	368407.Memar_0729	5.092e-36	139.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,2N9T3@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
DTH3_k127_5117840_0	1459636.NTE_02856	4.789e-187	593.0	COG5256@1|root,arCOG01561@2157|Archaea,41SD2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DTH3_k127_5117840_3	694429.Pyrfu_0228	7.389e-72	248.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
DTH3_k127_5117840_2	186497.PF1758	2.168e-79	276.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
DTH3_k127_5117840_7	1042877.GQS_06845	1.362e-50	194.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
DTH3_k127_5117840_5	391623.TERMP_00311	3.146e-64	233.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
DTH3_k127_5117840_13	192952.MM_2352	7.034e-06	51.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y49G@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5117840_6	1220534.B655_0165	9.073e-55	199.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,23NRI@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DTH3_k127_5117840_10	243231.GSU0773	1.407e-18	98.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH3_k127_5117840_1	386456.JQKN01000002_gene2748	1.248e-127	420.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,23NWK@183925|Methanobacteria	183925|Methanobacteria	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
DTH3_k127_5117840_9	1131266.ARWQ01000002_gene524	2.657e-29	124.0	COG1896@1|root,arCOG04311@2157|Archaea,41SQE@651137|Thaumarchaeota	651137|Thaumarchaeota	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
DTH3_k127_5117840_11	5932.XP_004034759.1	2.456e-10	66.0	COG1310@1|root,KOG1555@2759|Eukaryota,3ZCWI@5878|Ciliophora	5878|Ciliophora	O	Prokaryotic homologs of the JAB domain	-	-	-	ko:K03030	ko03050,ko05169,map03050,map05169	M00341	-	-	ko00000,ko00001,ko00002,ko01002,ko03051,ko04121	-	-	-	JAB,MitMem_reg
DTH3_k127_5137991_11	579137.Metvu_1603	5.684e-05	46.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,23R6Q@183939|Methanococci	183939|Methanococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
DTH3_k127_5137991_1	1365176.N186_04140	7.259e-137	449.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH3_k127_5137991_8	485916.Dtox_2805	8.844e-15	79.0	COG3448@1|root,COG3448@2|Bacteria,1UJ4A@1239|Firmicutes,25EVN@186801|Clostridia,267DA@186807|Peptococcaceae	186801|Clostridia	T	pfam cbs	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_5137991_6	443144.GM21_2836	1.877e-50	187.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,42SKH@68525|delta/epsilon subdivisions,2X60F@28221|Deltaproteobacteria,43UA2@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	[2Fe-2S] binding domain	pcmS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
DTH3_k127_5137991_2	216596.pRL80025	1.441e-95	342.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,4BME9@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5
DTH3_k127_5137991_3	767817.Desgi_0753	2.264e-59	216.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
DTH3_k127_5137991_9	1504822.CCNO01000011_gene54	7.287e-14	83.0	COG1775@1|root,COG1775@2|Bacteria,2NRF8@2323|unclassified Bacteria	2|Bacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
DTH3_k127_5137991_4	1321778.HMPREF1982_01001	1.566e-57	215.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia	186801|Clostridia	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
DTH3_k127_5137991_5	309799.DICTH_1431	2.411e-57	207.0	COG1139@1|root,COG1139@2|Bacteria	2|Bacteria	C	lactate oxidation	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
DTH3_k127_5137991_7	1131266.ARWQ01000001_gene1248	9.792e-32	128.0	arCOG08723@1|root,arCOG08723@2157|Archaea,41SPX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5137991_0	269799.Gmet_1297	5.813e-137	449.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,43SXK@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
DTH3_k127_5154461_1	1158318.ATXC01000001_gene402	3.824e-22	111.0	COG1269@1|root,COG1269@2|Bacteria,2G4GB@200783|Aquificae	200783|Aquificae	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DTH3_k127_5154461_3	1183377.Py04_0330	1.162e-12	76.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,243A6@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
DTH3_k127_5154461_0	868131.MSWAN_2243	1.86e-213	686.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
DTH3_k127_5154461_2	1236689.MMALV_14480	6.769e-18	85.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,3F2UW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
DTH3_k127_517537_4	1459636.NTE_01764	3.144e-53	192.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
DTH3_k127_517537_2	765177.Desmu_0797	2.503e-61	230.0	COG3425@1|root,arCOG01767@2157|Archaea,2XPKK@28889|Crenarchaeota	28889|Crenarchaeota	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C,HMG_CoA_synt_N,Thiolase_N
DTH3_k127_517537_1	1459636.NTE_00642	3.115e-99	330.0	COG0005@1|root,arCOG01327@2157|Archaea,41SDR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
DTH3_k127_517537_3	342949.PNA2_0786	1.601e-59	213.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,24312@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
DTH3_k127_517537_0	1321778.HMPREF1982_02819	3.745e-112	372.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,267RC@186813|unclassified Clostridiales	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
DTH3_k127_5236895_8	596151.DesfrDRAFT_1708	7.867e-07	57.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MBG2@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Universal stress protein	usp-2	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
DTH3_k127_5236895_0	589924.Ferp_0178	2.79e-84	292.0	COG1250@1|root,arCOG00251@2157|Archaea,2Y3BN@28890|Euryarchaeota,246SW@183980|Archaeoglobi	183980|Archaeoglobi	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
DTH3_k127_5236895_4	1499967.BAYZ01000139_gene119	8.024e-15	80.0	COG0346@1|root,COG0346@2|Bacteria,2NPRH@2323|unclassified Bacteria	2|Bacteria	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
DTH3_k127_5236895_6	399550.Smar_0669	2.284e-10	66.0	arCOG12413@1|root,arCOG12413@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5236895_1	316067.Geob_2830	1.369e-50	188.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WMNK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
DTH3_k127_5236895_2	931626.Awo_c22960	6.661e-33	139.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,25X3Z@186806|Eubacteriaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
DTH3_k127_5236895_3	342451.SSP1377	2.826e-30	134.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,4H9KQ@91061|Bacilli,4GY66@90964|Staphylococcaceae	91061|Bacilli	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004425,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
DTH3_k127_5236895_5	224324.aq_436	1.802e-10	63.0	COG1985@1|root,COG1985@2|Bacteria,2G3K5@200783|Aquificae	200783|Aquificae	H	PFAM bifunctional deaminase-reductase domain protein	ribD2	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.193	ko:K00082	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R03458	RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
DTH3_k127_5284520_6	410359.Pcal_1867	2.906e-12	70.0	COG3780@1|root,arCOG03156@2157|Archaea	2157|Archaea	L	ATPase involved in replication control Cdc46 Mcm family	-	-	2.7.7.7	ko:K02319,ko:K07332,ko:K07500,ko:K10726	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko02035,ko02044,ko03032	-	-	-	HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB,T2SSE
DTH3_k127_5284520_5	936155.HFELIS_16070	2.61e-14	74.0	2AICC@1|root,318TJ@2|Bacteria,1Q0XM@1224|Proteobacteria,431XH@68525|delta/epsilon subdivisions,2YSDI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5284520_8	1235793.C809_00001	0.0009967	46.0	2AU0F@1|root,31JKB@2|Bacteria,1V6XX@1239|Firmicutes,24KKM@186801|Clostridia	186801|Clostridia	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5284520_0	556261.HMPREF0240_00553	5.38e-57	212.0	COG0407@1|root,COG0407@2|Bacteria,1UGIQ@1239|Firmicutes,25P0U@186801|Clostridia,36RQW@31979|Clostridiaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH3_k127_5284520_2	1232437.KL662056_gene5461	7.154e-43	164.0	COG5012@1|root,COG5012@2|Bacteria,1PXIE@1224|Proteobacteria,42Q68@68525|delta/epsilon subdivisions,2WMEP@28221|Deltaproteobacteria,2MHPQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
DTH3_k127_5284520_4	273057.SSO1111	7.439e-35	138.0	COG1832@1|root,arCOG04227@2157|Archaea,2XQW5@28889|Crenarchaeota	28889|Crenarchaeota	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
DTH3_k127_5284520_3	515635.Dtur_0011	3.88e-40	153.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
DTH3_k127_5284520_1	332101.JIBU02000018_gene2248	6.52e-52	189.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,36DR1@31979|Clostridiaceae	186801|Clostridia	I	acyl-CoA dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DTH3_k127_5292347_7	1094980.Mpsy_1832	5.566e-35	137.0	COG0118@1|root,arCOG00089@2157|Archaea,2XTJ7@28890|Euryarchaeota,2N9N4@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DTH3_k127_5292347_4	436308.Nmar_1555	1.506e-55	200.0	COG0131@1|root,arCOG04398@2157|Archaea,41SGY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
DTH3_k127_5292347_8	1071085.KK033114_gene302	3.546e-25	119.0	COG0546@1|root,arCOG04692@2157|Archaea,2XUI7@28890|Euryarchaeota,23SAI@183963|Halobacteria	183963|Halobacteria	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
DTH3_k127_5292347_3	1304880.JAGB01000001_gene290	2.223e-63	232.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH3_k127_5292347_0	1220534.B655_1543	1.134e-113	381.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,23NVT@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
DTH3_k127_5292347_2	2325.TKV_c10850	1.262e-73	257.0	COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,42FE8@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
DTH3_k127_5292347_6	572478.Vdis_1974	9.158e-41	156.0	COG0184@1|root,arCOG04185@2157|Archaea,2XQ88@28889|Crenarchaeota	28889|Crenarchaeota	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
DTH3_k127_5292347_5	258594.RPA0225	1.934e-44	169.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2UC22@28211|Alphaproteobacteria,3JZIX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
DTH3_k127_5292347_1	673860.AciM339_1443	3.202e-92	321.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
DTH3_k127_5292347_9	1094980.Mpsy_2683	1.675e-12	71.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
DTH3_k127_5294097_2	545694.TREPR_2621	0.0004308	46.0	COG2848@1|root,COG2848@2|Bacteria,2J5GV@203691|Spirochaetes	203691|Spirochaetes	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
DTH3_k127_5294097_1	453591.Igni_1108	2.474e-104	354.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
DTH3_k127_5294097_0	1121090.KB894716_gene2762	2.912e-131	428.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,1ZBWV@1386|Bacillus	91061|Bacilli	C	isocitrate	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH3_k127_5294174_4	374847.Kcr_0387	8.907e-10	63.0	arCOG03119@1|root,arCOG03119@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DTH3_k127_5294174_3	1133849.O3I_024320	1.6e-18	86.0	COG3422@1|root,COG3422@2|Bacteria,2I1EE@201174|Actinobacteria,4G4W9@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF1508)	-	-	-	ko:K09946	-	-	-	-	ko00000	-	-	-	DUF1508
DTH3_k127_5294174_0	273057.SSO0469	9.109e-67	251.0	COG0433@1|root,arCOG00283@2157|Archaea,2XST3@28889|Crenarchaeota	28889|Crenarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
DTH3_k127_5294174_1	1121346.KB899821_gene2714	1.101e-59	214.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H9MA@91061|Bacilli,26QSG@186822|Paenibacillaceae	91061|Bacilli	I	3-hydroxyisobutyrate dehydrogenase	hopR	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2,PilZ
DTH3_k127_5343604_0	555079.Toce_0030	1.929e-44	168.0	COG0535@1|root,COG0535@2|Bacteria,1V3MC@1239|Firmicutes,24I1P@186801|Clostridia,42J5X@68295|Thermoanaerobacterales	186801|Clostridia	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
DTH3_k127_5343604_1	391623.TERMP_01864	6.983e-19	95.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,244YZ@183968|Thermococci	183968|Thermococci	L	Rad50 zinc hook motif	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_21,Rad50_zn_hook
DTH3_k127_534547_3	1094980.Mpsy_1848	2.412e-77	262.0	arCOG03571@1|root,arCOG03571@2157|Archaea,2Y1FB@28890|Euryarchaeota,2NAR3@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
DTH3_k127_534547_1	671065.MetMK1DRAFT_00013130	2.646e-155	506.0	COG1892@1|root,arCOG04435@2157|Archaea,2XQ6V@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppcA	GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0008964,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase_2
DTH3_k127_534547_2	1379698.RBG1_1C00001G1029	9.757e-147	475.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DTH3_k127_534547_0	521674.Plim_2046	8.605e-318	987.0	COG0542@1|root,COG0542@2|Bacteria,2IWYZ@203682|Planctomycetes	203682|Planctomycetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
DTH3_k127_5374614_1	342949.PNA2_0630	3.807e-69	242.0	COG2159@1|root,arCOG01931@2157|Archaea,2XV9F@28890|Euryarchaeota,243R6@183968|Thermococci	183968|Thermococci	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DTH3_k127_5374614_3	1121344.JHZO01000006_gene1788	1.934e-08	63.0	COG4720@1|root,COG4720@2|Bacteria,1V1E7@1239|Firmicutes,25CJR@186801|Clostridia,3WK3A@541000|Ruminococcaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
DTH3_k127_5374614_2	1229909.NSED_03350	1.146e-37	151.0	COG0388@1|root,arCOG00062@2157|Archaea	2157|Archaea	H	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
DTH3_k127_5374614_0	1042877.GQS_00940	2.657e-109	367.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
DTH3_k127_5374614_4	1192759.AKIB01000005_gene133	0.0009174	44.0	COG2336@1|root,COG2336@2|Bacteria,1N7UD@1224|Proteobacteria,2UFHF@28211|Alphaproteobacteria,2K729@204457|Sphingomonadales	204457|Sphingomonadales	T	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
DTH3_k127_5413862_17	192952.MM_1763	0.0004591	45.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,2N9PA@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DTH3_k127_5413862_2	1365176.N186_04385	4.983e-82	285.0	COG0142@1|root,arCOG01726@2157|Archaea,2XPZM@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the FPP GGPP synthase family	fgs	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
DTH3_k127_5413862_8	185453.XP_006833696.1	2.577e-31	126.0	COG1990@1|root,KOG3282@2759|Eukaryota,3A5QT@33154|Opisthokonta,3BSXK@33208|Metazoa,3D9MM@33213|Bilateria,48QWJ@7711|Chordata,49MGJ@7742|Vertebrata,3JPW6@40674|Mammalia,358T4@311790|Afrotheria	33208|Metazoa	S	Peptidyl-tRNA hydrolase PTH2	PTRH2	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0010941,GO:0010942,GO:0016787,GO:0016788,GO:0019222,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0052689,GO:0060255,GO:0060548,GO:0065007,GO:0140098,GO:0140101,GO:2000209,GO:2000210,GO:2000811	3.1.1.29	ko:K04794,ko:K18177	ko04714,map04714	-	-	-	ko00000,ko00001,ko01000,ko03012,ko03029	-	-	-	PTH2
DTH3_k127_5413862_7	195522.BD01_0986	2.196e-50	187.0	COG1409@1|root,arCOG01153@2157|Archaea,2XWZF@28890|Euryarchaeota,242KP@183968|Thermococci	183968|Thermococci	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DTH3_k127_5413862_12	694429.Pyrfu_0825	9.598e-16	84.0	COG1325@1|root,arCOG01042@2157|Archaea,2XQSI@28889|Crenarchaeota	28889|Crenarchaeota	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
DTH3_k127_5413862_13	1220534.B655_1256	1.028e-11	74.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,23P4P@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
DTH3_k127_5413862_16	1227500.C494_17533	4.291e-05	52.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,23VN6@183963|Halobacteria	183963|Halobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
DTH3_k127_5413862_3	647113.Metok_0269	2.002e-74	257.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23QEI@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
DTH3_k127_5413862_4	1459636.NTE_01339	1.148e-71	249.0	COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
DTH3_k127_5413862_5	694429.Pyrfu_1743	4.434e-57	207.0	COG1097@1|root,arCOG00678@2157|Archaea,2XQE2@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1,KH_6
DTH3_k127_5413862_0	391623.TERMP_00163	2.006e-90	304.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
DTH3_k127_5413862_1	1151117.AJLF01000002_gene83	3.476e-87	296.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
DTH3_k127_5413862_11	604354.TSIB_1345	7.545e-17	85.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
DTH3_k127_5413862_14	453591.Igni_0794	1.146e-06	57.0	COG2136@1|root,arCOG03247@2157|Archaea,2XQKN@28889|Crenarchaeota	28889|Crenarchaeota	J	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
DTH3_k127_5413862_15	1220534.B655_1246	2.23e-06	53.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y1HA@28890|Euryarchaeota,23P8R@183925|Methanobacteria	183925|Methanobacteria	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
DTH3_k127_5413862_10	1459636.NTE_01347	5.198e-22	100.0	COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
DTH3_k127_5413862_9	591019.Shell_1603	5.316e-31	134.0	COG0618@1|root,arCOG01565@2157|Archaea,2XQUB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
DTH3_k127_5413862_6	368408.Tpen_0714	8.347e-52	188.0	COG1122@1|root,arCOG00188@2157|Archaea	2157|Archaea	P	PFAM ABC transporter related	phnG	-	2.7.8.37	ko:K03529,ko:K06166,ko:K16786,ko:K16787	ko00440,ko02010,map00440,map02010	M00582	R10185	RC00005,RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko03036	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,PhnG,SMC_N,SMC_hinge
DTH3_k127_5450879_0	589865.DaAHT2_0922	1.913e-50	196.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,43BSZ@68525|delta/epsilon subdivisions,2WME9@28221|Deltaproteobacteria,2MMBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
DTH3_k127_5450879_1	593750.Metfor_0592	0.0001516	48.0	arCOG06510@1|root,arCOG06510@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
DTH3_k127_5578818_2	272844.PAB2123	2.555e-36	139.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,24405@183968|Thermococci	183968|Thermococci	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
DTH3_k127_5578818_3	399549.Msed_2053	1.1e-11	71.0	arCOG05900@1|root,arCOG05900@2157|Archaea,2XRDZ@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
DTH3_k127_5578818_0	1365176.N186_03390	2.063e-41	158.0	COG0091@1|root,arCOG04098@2157|Archaea,2XQCP@28889|Crenarchaeota	28889|Crenarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
DTH3_k127_5578818_1	1151117.AJLF01000002_gene49	9.16e-40	150.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
DTH3_k127_5615072_5	1120950.KB892746_gene3486	1.456e-07	57.0	COG0070@1|root,COG4733@1|root,COG0070@2|Bacteria,COG4733@2|Bacteria,2IB5W@201174|Actinobacteria	201174|Actinobacteria	E	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_5615072_1	697303.Thewi_0294	1.133e-97	331.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia,42EZ9@68295|Thermoanaerobacterales	186801|Clostridia	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
DTH3_k127_5615072_2	345219.Bcoa_2272	2.553e-36	141.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,1ZGG0@1386|Bacillus	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
DTH3_k127_5615072_3	1408428.JNJP01000024_gene3773	4.395e-24	111.0	COG2159@1|root,COG2159@2|Bacteria,1PWNH@1224|Proteobacteria,43EMG@68525|delta/epsilon subdivisions,2X128@28221|Deltaproteobacteria,2ME1X@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
DTH3_k127_5615072_0	340099.Teth39_0287	3.257e-128	421.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH3_k127_5615072_4	1232443.BAIA02000153_gene1732	3.788e-08	63.0	COG1082@1|root,COG1082@2|Bacteria,1UUVZ@1239|Firmicutes,24E3D@186801|Clostridia	186801|Clostridia	L	COG COG1082 Sugar phosphate isomerases epimerases	-	-	-	ko:K10709	-	-	-	-	ko00000	-	-	-	AP_endonuc_2
DTH3_k127_5701562_1	368408.Tpen_0712	2.823e-42	162.0	COG0619@1|root,arCOG02250@2157|Archaea	2157|Archaea	P	PFAM Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
DTH3_k127_5701562_0	368408.Tpen_0713	4.453e-80	275.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
DTH3_k127_5701562_2	1262449.CP6013_0878	2.416e-17	85.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,36F0E@31979|Clostridiaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
DTH3_k127_5715283_1	933801.Ahos_1245	3.324e-59	214.0	COG0462@1|root,arCOG00067@2157|Archaea,2XQE3@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
DTH3_k127_5715283_2	1220534.B655_0134	2.368e-49	190.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
DTH3_k127_5715283_0	269797.Mbar_A1789	2.847e-80	278.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
DTH3_k127_5715283_4	444157.Tneu_0685	3.289e-12	72.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
DTH3_k127_5715283_3	529709.PYCH_09240	1.66e-43	165.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2433T@183968|Thermococci	183968|Thermococci	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
DTH3_k127_5801718_0	269799.Gmet_2041	1.898e-30	135.0	COG0707@1|root,COG1819@1|root,COG0707@2|Bacteria,COG1819@2|Bacteria,1MW1K@1224|Proteobacteria,42Q6U@68525|delta/epsilon subdivisions,2WMIT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CG	PFAM UDP-glucuronosyl UDP-glucosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
DTH3_k127_5831510_2	1459636.NTE_01319	1.239e-100	333.0	arCOG00517@1|root,arCOG00517@2157|Archaea	2157|Archaea	P	COG0607 Rhodanese-related sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
DTH3_k127_5831510_1	247490.KSU1_C0538	2.41e-145	466.0	COG1741@1|root,COG1741@2|Bacteria,2IXVU@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
DTH3_k127_5831510_6	1038859.AXAU01000011_gene2414	1.803e-27	115.0	COG3070@1|root,COG3070@2|Bacteria,1P6Z6@1224|Proteobacteria	1224|Proteobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
DTH3_k127_5831510_7	1034943.BN1094_02354	2.318e-15	80.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,1S5VV@1236|Gammaproteobacteria,1JF0R@118969|Legionellales	118969|Legionellales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DTH3_k127_5831510_4	1343739.PAP_00210	4.723e-41	159.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XWRG@28890|Euryarchaeota,244Y6@183968|Thermococci	183968|Thermococci	Q	O-methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
DTH3_k127_5831510_10	521460.Athe_0413	3.044e-06	58.0	2DBCH@1|root,2Z8DH@2|Bacteria,1UZYN@1239|Firmicutes,24B0Q@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
DTH3_k127_5831510_3	589865.DaAHT2_1598	2.009e-41	160.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MKYF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
DTH3_k127_5831510_9	693661.Arcve_1058	5.507e-11	66.0	COG1280@1|root,arCOG01947@2157|Archaea,2XXV9@28890|Euryarchaeota,246CA@183980|Archaeoglobi	183980|Archaeoglobi	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
DTH3_k127_5831510_5	1499967.BAYZ01000033_gene1105	1.409e-35	141.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DTH3_k127_5831510_0	521011.Mpal_1433	0.0	1298.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2N97B@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DTH3_k127_5831510_8	387631.Asulf_01857	2.958e-13	74.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_5865285_1	469381.Dpep_1855	1.455e-59	231.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DTH3_k127_5865285_0	1499967.BAYZ01000132_gene305	2.412e-71	252.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DTH3_k127_5865285_2	1234664.AMRO01000054_gene18	0.0006581	50.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,1WFUZ@129337|Geobacillus	91061|Bacilli	P	N-terminal TM domain of oligopeptide transport permease C	dppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DTH3_k127_5911864_4	311424.DhcVS_1238	4.604e-18	91.0	COG0350@1|root,COG0350@2|Bacteria,2G6TT@200795|Chloroflexi,34DBJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
DTH3_k127_5911864_1	933801.Ahos_0777	4.78e-51	186.0	COG1056@1|root,arCOG00972@2157|Archaea,2XQI1@28889|Crenarchaeota	28889|Crenarchaeota	F	nicotinamide-nucleotide adenylyltransferase	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
DTH3_k127_5911864_0	999630.TUZN_1856	1.123e-59	219.0	COG1912@1|root,arCOG04309@2157|Archaea,2XQIS@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
DTH3_k127_5911864_2	195522.BD01_0455	1.105e-41	161.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXMZ@28890|Euryarchaeota,245B2@183968|Thermococci	183968|Thermococci	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
DTH3_k127_5911864_3	572546.Arcpr_0223	3.745e-25	110.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,245TM@183980|Archaeoglobi	183980|Archaeoglobi	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
DTH3_k127_5931165_4	70601.3258234	2.961e-79	294.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DTH3_k127_5931165_12	268739.Nmlp_1668	0.00026	51.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,23TJC@183963|Halobacteria	183963|Halobacteria	L	chromosome segregation and condensation protein ScpA	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
DTH3_k127_5931165_8	529709.PYCH_12850	4.18e-26	115.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,242WQ@183968|Thermococci	183968|Thermococci	K	Segregation and condensation complex subunit ScpB	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
DTH3_k127_5931165_7	644281.MFS40622_1507	2.418e-29	122.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23R0Z@183939|Methanococci	183939|Methanococci	J	PFAM ribosomal protein S8E	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
DTH3_k127_5931165_9	1220534.B655_2369	1.622e-13	74.0	COG1400@1|root,arCOG01217@2157|Archaea,2XYV0@28890|Euryarchaeota,23P73@183925|Methanobacteria	183925|Methanobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
DTH3_k127_5931165_0	693661.Arcve_0242	4.315e-194	625.0	COG0303@1|root,COG1910@1|root,arCOG00217@2157|Archaea,arCOG00230@2157|Archaea,2XT2V@28890|Euryarchaeota,245ZM@183980|Archaeoglobi	183980|Archaeoglobi	H	Molybdenum cofactor synthesis domain protein	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
DTH3_k127_5931165_10	186497.PF1791	3.194e-13	72.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,244GS@183968|Thermococci	183968|Thermococci	J	H ACA RNA-protein complex	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
DTH3_k127_5931165_2	1236689.MMALV_00330	1.577e-111	368.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,3F2FH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
DTH3_k127_5931165_3	933262.AXAM01000005_gene2470	1.31e-109	367.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria,2MK14@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DTH3_k127_5931165_5	98439.AJLL01000100_gene502	1.234e-58	210.0	COG1839@1|root,COG1839@2|Bacteria,1G575@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
DTH3_k127_5931165_1	868131.MSWAN_1000	6.662e-152	494.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,23NUS@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
DTH3_k127_5931165_11	1365176.N186_02870	1.525e-11	69.0	COG1522@1|root,arCOG04153@2157|Archaea,2XR1T@28889|Crenarchaeota	28889|Crenarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC,HTH_24,MarR
DTH3_k127_5931165_6	416348.Hlac_0434	1.786e-47	177.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,23T6V@183963|Halobacteria	183963|Halobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rrmJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,TRAM
DTH3_k127_59687_7	6500.XP_005111686.1	0.0001312	50.0	KOG2649@1|root,KOG2649@2759|Eukaryota,38R1Y@33154|Opisthokonta,3BD7D@33208|Metazoa,3CSIH@33213|Bilateria	33208|Metazoa	S	metallocarboxypeptidase activity	CPM	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009653,GO:0009986,GO:0009987,GO:0010467,GO:0016020,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0032502,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044421,GO:0044464,GO:0048856,GO:0051604,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.17.12	ko:K01296	-	-	-	-	ko00000,ko00537,ko01000,ko01002	-	-	-	CarboxypepD_reg,Peptidase_M14
DTH3_k127_59687_6	536233.CLO_0797	2.3e-10	69.0	COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,36GKK@31979|Clostridiaceae	186801|Clostridia	E	Vitamin B12 dependent methionine synthase activation	metH2	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
DTH3_k127_59687_5	521045.Kole_0994	7.808e-34	145.0	COG3875@1|root,COG3875@2|Bacteria,2GD6T@200918|Thermotogae	200918|Thermotogae	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DTH3_k127_59687_2	224325.AF_0009	5.244e-66	236.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2474P@183980|Archaeoglobi	183980|Archaeoglobi	H	Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
DTH3_k127_59687_3	1268072.PSAB_12505	9.276e-62	221.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,26SBQ@186822|Paenibacillaceae	91061|Bacilli	IQ	short-chain	-	-	1.1.1.47,1.1.1.53,1.1.1.69	ko:K00034,ko:K00038,ko:K00046	ko00030,ko00140,ko01100,ko01120,ko01200,map00030,map00140,map01100,map01120,map01200	-	R01520,R01521,R04831,R04834,R04844,R04847	RC00066,RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
DTH3_k127_59687_0	1307436.PBF_16399	1.346e-111	374.0	COG0001@1|root,COG0001@2|Bacteria,1TRD7@1239|Firmicutes,4HA12@91061|Bacilli,1ZCDI@1386|Bacillus	91061|Bacilli	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH3_k127_59687_4	1097668.BYI23_C008760	4.217e-60	220.0	COG2421@1|root,COG2421@2|Bacteria,1N12N@1224|Proteobacteria,2VW2M@28216|Betaproteobacteria,1KGSG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Acetamidase/Formamidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
DTH3_k127_59687_1	768704.Desmer_0567	9.238e-67	235.0	COG1028@1|root,COG1028@2|Bacteria,1TZY6@1239|Firmicutes,248QZ@186801|Clostridia,2616V@186807|Peptococcaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	fabG5	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DTH3_k127_6006548_8	1121413.JMKT01000011_gene2391	5.864e-13	70.0	COG4231@1|root,COG4231@2|Bacteria,1N6WI@1224|Proteobacteria,42V3I@68525|delta/epsilon subdivisions,2WRKA@28221|Deltaproteobacteria,2MD6W@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DTH3_k127_6006548_3	1408303.JNJJ01000046_gene980	1.906e-106	358.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4IMZ2@91061|Bacilli,1ZM9X@1386|Bacillus	91061|Bacilli	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
DTH3_k127_6006548_1	218284.CCDN010000001_gene315	1.66e-109	367.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli,1ZDIH@1386|Bacillus	91061|Bacilli	S	amidohydrolase	hmrA	-	-	ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
DTH3_k127_6006548_7	1499967.BAYZ01000009_gene5283	3.342e-21	93.0	COG1773@1|root,COG1773@2|Bacteria,2NS28@2323|unclassified Bacteria	2|Bacteria	C	Rubredoxin	rub	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
DTH3_k127_6006548_4	515635.Dtur_0260	1.265e-48	180.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
DTH3_k127_6006548_6	985053.VMUT_0348	1.136e-28	119.0	COG1144@1|root,arCOG01604@2157|Archaea,2XQU1@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
DTH3_k127_6006548_0	926561.KB900617_gene2305	4.057e-120	399.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,3WAF8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
DTH3_k127_6006548_2	368408.Tpen_0574	4.722e-107	355.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
DTH3_k127_6006548_5	1121422.AUMW01000002_gene2121	4.065e-37	143.0	COG1917@1|root,COG1917@2|Bacteria,1UHAE@1239|Firmicutes,24C81@186801|Clostridia	186801|Clostridia	S	Cupin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DTH3_k127_6006548_9	573061.Clocel_3701	4.605e-09	60.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,36F0E@31979|Clostridiaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
DTH3_k127_6007648_2	192952.MM_0813	2.29e-97	325.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota,2NANV@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
DTH3_k127_6007648_1	37659.JNLN01000001_gene1543	7.556e-180	574.0	COG0415@1|root,COG0415@2|Bacteria,1UDZT@1239|Firmicutes,249FJ@186801|Clostridia,36FVA@31979|Clostridiaceae	186801|Clostridia	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase
DTH3_k127_6007648_5	351160.LRC349	5.248e-26	113.0	COG3467@1|root,arCOG00520@2157|Archaea,2XXWD@28890|Euryarchaeota,2NAW4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
DTH3_k127_6007648_9	1380347.JNII01000007_gene681	7.481e-06	56.0	COG2314@1|root,COG2314@2|Bacteria	2|Bacteria	J	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,DUF4190,DUF4352
DTH3_k127_6007648_4	565033.GACE_1086	4.554e-38	147.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,2467Y@183980|Archaeoglobi	183980|Archaeoglobi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
DTH3_k127_6007648_8	985053.VMUT_1519	1.908e-13	75.0	COG1917@1|root,arCOG02999@2157|Archaea	2157|Archaea	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DTH3_k127_6007648_10	926569.ANT_15990	8.774e-06	50.0	COG0550@1|root,COG0550@2|Bacteria,2G5ZR@200795|Chloroflexi	200795|Chloroflexi	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
DTH3_k127_6007648_3	1163730.FFONT_0663	2.424e-67	238.0	COG5014@1|root,arCOG05120@2157|Archaea,2XPWW@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
DTH3_k127_6007648_0	374847.Kcr_0911	3.086e-201	641.0	COG0129@1|root,arCOG04045@2157|Archaea	2157|Archaea	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
DTH3_k127_6007648_6	1120949.KB903317_gene1617	7.377e-25	106.0	COG3324@1|root,COG3324@2|Bacteria,2IRXF@201174|Actinobacteria,4DEWK@85008|Micromonosporales	201174|Actinobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
DTH3_k127_6007648_7	1304885.AUEY01000002_gene433	5.606e-19	88.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MHUJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Periplasmic sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_3,Response_reg
DTH3_k127_6022482_1	1459636.NTE_03282	2.004e-32	132.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_6022482_0	877455.Metbo_0295	3.88e-34	141.0	COG0517@1|root,arCOG00602@2157|Archaea,2XYM5@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_6022482_2	368407.Memar_1796	3.407e-26	111.0	COG0517@1|root,arCOG00600@2157|Archaea,2XX02@28890|Euryarchaeota,2N9I1@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_6054333_0	589924.Ferp_1748	1.016e-141	467.0	COG0633@1|root,COG3894@1|root,arCOG02035@2157|Archaea,arCOG02842@2157|Archaea,2XVBE@28890|Euryarchaeota,246NQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
DTH3_k127_6054333_1	1459636.NTE_01645	1.273e-87	301.0	COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
DTH3_k127_6054333_2	1459636.NTE_00653	4.891e-35	143.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
DTH3_k127_6067023_0	311424.DhcVS_1132	2.919e-44	170.0	COG2197@1|root,COG2197@2|Bacteria,2G6K0@200795|Chloroflexi,34D88@301297|Dehalococcoidia	301297|Dehalococcoidia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DTH3_k127_6067023_1	1242864.D187_009177	5.467e-16	83.0	COG3055@1|root,COG5492@1|root,COG3055@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	ligA1	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF3494
DTH3_k127_6083663_1	1232437.KL662042_gene2024	8.459e-10	68.0	COG4122@1|root,COG5423@1|root,COG4122@2|Bacteria,COG5423@2|Bacteria,1QWN3@1224|Proteobacteria,42Q2N@68525|delta/epsilon subdivisions,2WM7P@28221|Deltaproteobacteria,2MIYM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284,Dimerisation2,Methyltransf_2
DTH3_k127_6083663_0	909663.KI867150_gene2777	5.149e-48	174.0	COG0582@1|root,COG0582@2|Bacteria,1RCN8@1224|Proteobacteria,42RD9@68525|delta/epsilon subdivisions,2WMVF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	viral genome integration into host DNA	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
DTH3_k127_6126546_0	237368.SCABRO_03612	1.724e-101	337.0	COG0656@1|root,COG0656@2|Bacteria,2IWVI@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Aldo keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DTH3_k127_6126546_1	1220534.B655_1291	8.129e-42	160.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
DTH3_k127_6126546_2	221288.JH992901_gene3767	2.543e-41	162.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DTH3_k127_6193111_0	1128421.JAGA01000002_gene1443	1.035e-119	393.0	COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria	2|Bacteria	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
DTH3_k127_6193111_4	666510.ASAC_0035	3.906e-07	55.0	arCOG05464@1|root,arCOG05464@2157|Archaea,2XR3S@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6193111_1	1209989.TepiRe1_0442	8.671e-69	244.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,42JCA@68295|Thermoanaerobacterales	186801|Clostridia	C	COGs COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase	-	-	1.1.1.291,1.1.1.31,1.1.1.60	ko:K00020,ko:K00042,ko:K19647	ko00280,ko00630,ko00760,ko01100,ko01120,map00280,map00630,map00760,map01100,map01120	-	R01745,R01747,R05066,R07985	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
DTH3_k127_6193111_2	1459636.NTE_03013	4.676e-64	228.0	COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
DTH3_k127_6193111_3	246969.TAM4_704	8.88e-40	156.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
DTH3_k127_6200700_1	1151117.AJLF01000001_gene704	4.353e-07	63.0	COG5617@1|root,arCOG07110@2157|Archaea,2Y38Y@28890|Euryarchaeota,24337@183968|Thermococci	183968|Thermococci	S	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related
DTH3_k127_6200700_0	1459636.NTE_00782	4.026e-40	165.0	COG1708@1|root,arCOG01186@1|root,arCOG01186@2157|Archaea,arCOG07292@2157|Archaea	2157|Archaea	G	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	APH,NTP_transf_2
DTH3_k127_6203266_1	1041930.Mtc_1413	1.348e-11	75.0	arCOG03442@1|root,arCOG03442@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6203266_0	1120960.ATXG01000011_gene3547	1.573e-13	83.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
DTH3_k127_6204391_0	1229909.NSED_05280	5.702e-08	64.0	arCOG06883@1|root,arCOG06883@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2334,DZR
DTH3_k127_6273536_2	572479.Hprae_2075	6.623e-34	147.0	2DFXS@1|root,2ZTMH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330,Kunitz_BPTI
DTH3_k127_6273536_3	1123008.KB905696_gene3060	1.749e-17	83.0	2EMYX@1|root,33FM2@2|Bacteria,4NY90@976|Bacteroidetes,2FZJV@200643|Bacteroidia,2314D@171551|Porphyromonadaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6273536_4	945713.IALB_2396	2.617e-06	57.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,Sortilin-Vps10
DTH3_k127_6273536_0	748280.NH8B_1377	0.0	1266.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,2KQCR@206351|Neisseriales	206351|Neisseriales	C	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
DTH3_k127_6273536_1	1379698.RBG1_1C00001G0658	3.832e-68	238.0	arCOG08955@1|root,2ZN6H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6292471_2	316067.Geob_0219	1.139e-14	77.0	COG1034@1|root,COG1034@2|Bacteria,1R9D1@1224|Proteobacteria,42PDV@68525|delta/epsilon subdivisions,2WIUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_7
DTH3_k127_6292471_3	986075.CathTA2_0465	1.429e-07	63.0	COG1633@1|root,COG1633@2|Bacteria,1V4ZN@1239|Firmicutes,4HH0Q@91061|Bacilli	91061|Bacilli	S	bacterioferritin	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
DTH3_k127_6292471_0	706587.Desti_1767	4.971e-209	658.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,2MRHI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
DTH3_k127_6408323_5	795666.MW7_3330	1.505e-29	121.0	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,2VZW4@28216|Betaproteobacteria,1K2DF@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
DTH3_k127_6408323_0	1382356.JQMP01000001_gene1157	1.995e-138	450.0	COG1060@1|root,COG1060@2|Bacteria,2GBD4@200795|Chloroflexi,27YV4@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
DTH3_k127_6408323_1	498761.HM1_2374	6.491e-111	370.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DTH3_k127_6408323_8	267377.MMP1032	3.769e-06	57.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
DTH3_k127_6408323_6	1041930.Mtc_1091	3.026e-19	87.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
DTH3_k127_6408323_3	1313421.JHBV01000005_gene4566	1.886e-50	191.0	COG0451@1|root,COG0451@2|Bacteria,4NE3U@976|Bacteroidetes,1IQ61@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM NAD dependent epimerase dehydratase family	tdh	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DTH3_k127_6408323_7	351160.RCIX2657	1.39e-15	87.0	COG1575@1|root,arCOG00480@2157|Archaea,2XXM6@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
DTH3_k127_6408323_2	391625.PPSIR1_26958	1e-51	195.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,42RJF@68525|delta/epsilon subdivisions,2WNGK@28221|Deltaproteobacteria,2Z0BU@29|Myxococcales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DTH3_k127_6408323_4	523850.TON_0889	2.571e-37	151.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MI@28890|Euryarchaeota,243IW@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DTH3_k127_6408323_9	572546.Arcpr_0277	2.215e-05	55.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,24693@183980|Archaeoglobi	183980|Archaeoglobi	N	Peptidase A24B, FlaK domain protein	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
DTH3_k127_6430467_1	309807.SRU_1457	1.212e-59	218.0	COG1335@1|root,COG1335@2|Bacteria,4NKPP@976|Bacteroidetes,1FIZM@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
DTH3_k127_6430467_2	589924.Ferp_1683	3.981e-46	183.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_6430467_4	604354.TSIB_0281	8.068e-22	108.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EI@28890|Euryarchaeota,242RF@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DTH3_k127_6430467_0	593750.Metfor_2107	5.439e-64	224.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota,2NAWN@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
DTH3_k127_6430467_3	386456.JQKN01000001_gene2349	9.928e-34	132.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
DTH3_k127_6524188_1	368407.Memar_0876	2.012e-111	369.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUJG@28890|Euryarchaeota,2N9IV@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DTH3_k127_6524188_2	1365176.N186_07110	2.984e-45	173.0	COG0013@1|root,arCOG01254@2157|Archaea,2XQGA@28889|Crenarchaeota	28889|Crenarchaeota	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
DTH3_k127_6524188_0	290315.Clim_1236	3.389e-215	679.0	COG0433@1|root,COG0433@2|Bacteria,1FEIF@1090|Chlorobi	1090|Chlorobi	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
DTH3_k127_6524992_0	1037409.BJ6T_21760	8.858e-62	221.0	2C2X7@1|root,31WBU@2|Bacteria,1P2EC@1224|Proteobacteria,2UV16@28211|Alphaproteobacteria,3JWR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
DTH3_k127_6524992_1	338966.Ppro_0395	2.183e-43	165.0	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,42XWP@68525|delta/epsilon subdivisions,2WSIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6587073_0	593750.Metfor_2049	9.267e-84	282.0	COG4294@1|root,arCOG01898@2157|Archaea,2XVT2@28890|Euryarchaeota	28890|Euryarchaeota	L	UV-endonuclease UvdE	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
DTH3_k127_6587073_1	1313304.CALK_2504	3.652e-19	93.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
DTH3_k127_6602494_0	1094980.Mpsy_2769	1.802e-115	381.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
DTH3_k127_6602494_1	909663.KI867150_gene853	6.941e-115	376.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,2MR5B@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
DTH3_k127_6602494_3	509191.AEDB02000076_gene1453	1.359e-08	66.0	COG5542@1|root,COG5542@2|Bacteria	2|Bacteria	O	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
DTH3_k127_6602494_2	1499967.BAYZ01000057_gene4700	4.131e-81	286.0	COG1541@1|root,COG1541@2|Bacteria,2NR9N@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
DTH3_k127_6602494_4	667014.Thein_0536	0.0002799	46.0	COG0688@1|root,COG0688@2|Bacteria,2GHHU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Phosphatidylserine decarboxylase	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
DTH3_k127_6612061_3	292459.STH1872	6.99e-37	142.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH3_k127_6612061_1	479434.Sthe_1506	4.729e-99	346.0	COG1574@1|root,COG1574@2|Bacteria,2GB76@200795|Chloroflexi,27XM1@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
DTH3_k127_6612061_0	645991.Sgly_1585	1.299e-165	540.0	COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,249N1@186801|Clostridia,260S4@186807|Peptococcaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
DTH3_k127_6612061_4	1382306.JNIM01000001_gene440	5.16e-19	96.0	COG0477@1|root,COG2814@2|Bacteria,2G97R@200795|Chloroflexi	200795|Chloroflexi	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH3_k127_6612061_2	1121342.AUCO01000016_gene2738	8.51e-41	158.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,36ETU@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
DTH3_k127_674797_4	443143.GM18_4304	6.131e-70	249.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
DTH3_k127_674797_2	56780.SYN_02058	3.021e-98	340.0	COG0348@1|root,COG1143@1|root,COG1245@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1245@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2MSKF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
DTH3_k127_674797_8	1165841.SULAR_02623	2.718e-26	112.0	COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2YPEG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	ADP-ribose pyrophosphatase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
DTH3_k127_674797_7	273057.SSO1591	1.897e-34	142.0	arCOG05339@1|root,arCOG05339@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_674797_3	1229909.NSED_02970	4.779e-75	260.0	COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Chlorophyllase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
DTH3_k127_674797_9	1054213.HMPREF9946_02468	3.361e-16	83.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,2JS47@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
DTH3_k127_674797_6	1094980.Mpsy_0942	9.351e-44	165.0	COG2119@1|root,arCOG03458@2157|Archaea,2XYST@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
DTH3_k127_674797_1	370438.PTH_0247	1.761e-137	444.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,260EI@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH3_k127_674797_0	1094980.Mpsy_0120	1.983e-210	660.0	COG2873@1|root,arCOG00061@2157|Archaea,2XSWM@28890|Euryarchaeota,2N9AN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
DTH3_k127_674797_5	1459636.NTE_01853	2.686e-64	230.0	COG0460@1|root,arCOG01351@2157|Archaea,41SAC@651137|Thaumarchaeota	651137|Thaumarchaeota	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
DTH3_k127_6844852_1	1291050.JAGE01000002_gene3569	9.009e-46	170.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,3WHBS@541000|Ruminococcaceae	186801|Clostridia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
DTH3_k127_6844852_0	192952.MM_0633	9.751e-72	258.0	arCOG05009@1|root,arCOG05009@2157|Archaea,2XZTV@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
DTH3_k127_6844852_2	1380408.AVGH01000005_gene2565	2.559e-24	108.0	COG0607@1|root,COG0607@2|Bacteria,1VES3@1239|Firmicutes,4HQN2@91061|Bacilli,21X2R@150247|Anoxybacillus	91061|Bacilli	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
DTH3_k127_6844852_4	365046.Rta_12870	3.857e-10	62.0	COG1942@1|root,COG1942@2|Bacteria,1N8I6@1224|Proteobacteria,2VW8C@28216|Betaproteobacteria,4AFEI@80864|Comamonadaceae	28216|Betaproteobacteria	G	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
DTH3_k127_6845010_3	1382306.JNIM01000001_gene1898	8.4e-20	97.0	COG1920@1|root,COG1920@2|Bacteria,2G76R@200795|Chloroflexi	200795|Chloroflexi	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
DTH3_k127_6845010_1	485913.Krac_0981	3.541e-92	312.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM LPPG domain protein containing protein	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
DTH3_k127_6845010_0	246969.TAM4_485	7.805e-166	541.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DTH3_k127_6927130_2	304371.MCP_1815	9.111e-49	182.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,2N9Z2@224756|Methanomicrobia	224756|Methanomicrobia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH3_k127_6927130_0	1071073.KI530551_gene3786	3.697e-67	242.0	COG1409@1|root,COG1409@2|Bacteria,1TPQQ@1239|Firmicutes,4HC2W@91061|Bacilli,1ZCF0@1386|Bacillus	91061|Bacilli	Q	Calcineurin-like phosphoesterase	yvnB	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,LTD,Metallophos,SLH,fn3
DTH3_k127_6927130_1	755731.Clo1100_3318	5.927e-56	213.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,36E8H@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
DTH3_k127_6927130_4	342949.PNA2_0630	0.0003189	45.0	COG2159@1|root,arCOG01931@2157|Archaea,2XV9F@28890|Euryarchaeota,243R6@183968|Thermococci	183968|Thermococci	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DTH3_k127_6927130_3	1396141.BATP01000003_gene4975	4.157e-23	116.0	COG1361@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,46WJ7@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
DTH3_k127_6952510_1	1094466.KQS_05650	4.682e-72	249.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,1HX5F@117743|Flavobacteriia,2NTN0@237|Flavobacterium	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
DTH3_k127_6952510_2	386456.JQKN01000004_gene198	1.505e-54	195.0	COG0229@1|root,arCOG02815@2157|Archaea,2XXVK@28890|Euryarchaeota	28890|Euryarchaeota	O	COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
DTH3_k127_6952510_3	96561.Dole_1005	9.318e-17	83.0	2CI6U@1|root,33N1H@2|Bacteria,1NQ5J@1224|Proteobacteria,42XMU@68525|delta/epsilon subdivisions,2WSUP@28221|Deltaproteobacteria,2MMAA@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6952510_0	756499.Desde_2069	3.184e-74	258.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
DTH3_k127_6974240_0	335543.Sfum_1184	6.245e-132	435.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6982567_1	525909.Afer_0450	5.969e-27	124.0	COG5650@1|root,COG5650@2|Bacteria,2I9AM@201174|Actinobacteria	201174|Actinobacteria	S	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_6982567_2	1163730.FFONT_0168	7.166e-10	72.0	COG0467@1|root,arCOG01171@2157|Archaea,2XPNC@28889|Crenarchaeota	28889|Crenarchaeota	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DTH3_k127_6982567_0	768672.Desfe_0142	1.347e-36	147.0	COG0467@1|root,arCOG01171@2157|Archaea,2XPNC@28889|Crenarchaeota	28889|Crenarchaeota	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DTH3_k127_719046_14	305700.B447_19054	5.363e-05	51.0	COG2457@1|root,COG2457@2|Bacteria,1RD0V@1224|Proteobacteria,2VS9E@28216|Betaproteobacteria,2KWHC@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
DTH3_k127_719046_5	1041930.Mtc_1505	8.076e-81	281.0	COG1907@1|root,arCOG01026@2157|Archaea,2XUFK@28890|Euryarchaeota,2N92U@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P)	-	-	2.4.2.54	ko:K06984	ko00790,map00790	-	R10337,R11102	-	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C
DTH3_k127_719046_4	351160.RCIX1510	2.409e-89	314.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,2N967@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
DTH3_k127_719046_13	1094980.Mpsy_2167	4.862e-07	60.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_719046_8	877455.Metbo_0053	2.383e-32	133.0	COG1280@1|root,arCOG01947@2157|Archaea,2XY47@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
DTH3_k127_719046_12	1365176.N186_09185	1.542e-08	67.0	arCOG03671@1|root,arCOG10888@1|root,arCOG03671@2157|Archaea,arCOG10888@2157|Archaea	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Thermopsin
DTH3_k127_719046_0	1459636.NTE_01192	1.458e-211	672.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
DTH3_k127_719046_2	694429.Pyrfu_0102	1.543e-203	647.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPYR@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsB	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
DTH3_k127_719046_11	399550.Smar_0944	1.396e-22	98.0	COG2126@1|root,arCOG04126@2157|Archaea,2XR4H@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl37e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
DTH3_k127_719046_10	1459636.NTE_02161	1.626e-23	101.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
DTH3_k127_719046_9	267377.MMP0055	4.235e-24	108.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,23QZV@183939|Methanococci	183939|Methanococci	J	PFAM PUA domain containing protein	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
DTH3_k127_719046_1	693661.Arcve_1165	2.564e-210	671.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,245T2@183980|Archaeoglobi	183980|Archaeoglobi	S	metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,RMMBL
DTH3_k127_719046_6	565033.GACE_1789	1.774e-60	216.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,245UT@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DTH3_k127_719046_7	1459636.NTE_02621	9.825e-60	215.0	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
DTH3_k127_719046_3	604354.TSIB_0686	6.777e-109	377.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
DTH3_k127_7260935_9	368408.Tpen_0621	1.122e-34	147.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
DTH3_k127_7260935_15	1131266.ARWQ01000006_gene249	3.972e-07	54.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
DTH3_k127_7260935_5	572547.Amico_1311	1.552e-65	237.0	COG4927@1|root,COG4927@2|Bacteria,3TB4S@508458|Synergistetes	508458|Synergistetes	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
DTH3_k127_7260935_16	877455.Metbo_1485	0.000611	46.0	COG0640@1|root,arCOG00731@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DTH3_k127_7260935_1	572546.Arcpr_1565	4.477e-297	948.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
DTH3_k127_7260935_17	555779.Dthio_PD2721	0.0006493	51.0	28K33@1|root,2Z9SC@2|Bacteria,1Q1U9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7260935_8	580331.Thit_0099	4.669e-38	152.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,42FZQ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM hydrolase, TatD family	yabD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
DTH3_k127_7260935_12	953739.SVEN_1801	1.412e-13	79.0	COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
DTH3_k127_7260935_14	985053.VMUT_1615	5.73e-10	63.0	COG4888@1|root,arCOG04136@2157|Archaea,2XRI7@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
DTH3_k127_7260935_6	457570.Nther_2211	6.666e-56	204.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia	186801|Clostridia	O	XanTHIne and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
DTH3_k127_7260935_11	572546.Arcpr_1468	3.564e-28	119.0	COG0171@1|root,COG1372@1|root,arCOG00069@2157|Archaea,arCOG03145@2157|Archaea,2XT7M@28890|Euryarchaeota,24632@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
DTH3_k127_7260935_10	985053.VMUT_0432	2.201e-30	124.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
DTH3_k127_7260935_7	1444306.JFZC01000012_gene2013	1.538e-55	204.0	COG0388@1|root,COG0388@2|Bacteria,1V4HM@1239|Firmicutes,4IQ6E@91061|Bacilli	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DTH3_k127_7260935_13	1459636.NTE_00083	1.598e-13	76.0	arCOG04038@1|root,arCOG04038@2157|Archaea,41SQU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7260935_0	880072.Desac_1143	0.0	1093.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DTH3_k127_7260935_3	593117.TGAM_0128	3.026e-118	394.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
DTH3_k127_7260935_4	1041930.Mtc_0452	7.426e-99	341.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
DTH3_k127_7260935_2	342949.PNA2_1872	6.157e-135	445.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DTH3_k127_7262058_5	357808.RoseRS_4534	8.72e-33	130.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,3756Y@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
DTH3_k127_7262058_0	1009370.ALO_11729	2.554e-109	367.0	COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,4H3EN@909932|Negativicutes	909932|Negativicutes	C	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DTH3_k127_7262058_3	903814.ELI_3312	7.972e-35	143.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,25VVJ@186806|Eubacteriaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
DTH3_k127_7262058_4	565033.GACE_1311	1.58e-34	143.0	COG2057@1|root,arCOG05316@2157|Archaea,2XW2C@28890|Euryarchaeota,246AI@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
DTH3_k127_7262058_2	224325.AF_1199	9.551e-56	205.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
DTH3_k127_7262058_1	867903.ThesuDRAFT_00399	2.862e-107	355.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WCH9@538999|Clostridiales incertae sedis	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DTH3_k127_7314763_2	604354.TSIB_0031	1.328e-47	177.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
DTH3_k127_7314763_1	456442.Mboo_0613	2.517e-51	197.0	COG0842@1|root,arCOG01467@2157|Archaea,2Y87M@28890|Euryarchaeota,2NBP0@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DTH3_k127_7314763_0	192952.MM_2455	2.577e-95	323.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DTH3_k127_7344315_0	1459636.NTE_02878	4.205e-180	579.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
DTH3_k127_7344315_1	453591.Igni_0637	1.562e-72	252.0	COG0519@1|root,arCOG00085@2157|Archaea,2XPVC@28889|Crenarchaeota	28889|Crenarchaeota	F	GMP synthase, glutamine-hydrolyzing	guaA	GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
DTH3_k127_7349137_12	589924.Ferp_0123	1.753e-22	99.0	COG0437@1|root,arCOG01500@2157|Archaea,2XU83@28890|Euryarchaeota,246KB@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
DTH3_k127_7349137_3	1230460.C495_04757	2.341e-90	313.0	COG5557@1|root,arCOG02025@2157|Archaea,2XTP4@28890|Euryarchaeota,23S4Z@183963|Halobacteria	183963|Halobacteria	C	Polysulphide reductase	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
DTH3_k127_7349137_16	797299.HALLA_20665	0.000307	45.0	arCOG10320@1|root,arCOG10320@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7349137_7	1220534.B655_0860	1.448e-44	176.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23NK4@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
DTH3_k127_7349137_15	1304888.ATWF01000002_gene508	6.735e-11	67.0	COG2332@1|root,COG2332@2|Bacteria,2GFT9@200930|Deferribacteres	200930|Deferribacteres	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
DTH3_k127_7349137_6	635013.TherJR_2276	7.393e-50	185.0	COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,24IWH@186801|Clostridia,264K0@186807|Peptococcaceae	186801|Clostridia	O	Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
DTH3_k127_7349137_10	589924.Ferp_0352	9.086e-26	115.0	COG2386@1|root,arCOG01328@2157|Archaea,2XTAS@28890|Euryarchaeota,2466T@183980|Archaeoglobi	183980|Archaeoglobi	O	ABC-type transport system involved in cytochrome c biogenesis permease component	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
DTH3_k127_7349137_9	1449080.JQMV01000003_gene2173	1.083e-43	167.0	COG4555@1|root,COG4555@2|Bacteria,1WIIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CP	ABC transporter	-	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
DTH3_k127_7349137_2	1459636.NTE_02820	1.192e-138	453.0	COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DTH3_k127_7349137_14	1094980.Mpsy_1324	1.263e-14	77.0	COG0721@1|root,arCOG02726@2157|Archaea,2XYQ0@28890|Euryarchaeota,2N9Z4@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
DTH3_k127_7349137_0	748449.Halha_2302	3.265e-167	539.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,3WA7Q@53433|Halanaerobiales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
DTH3_k127_7349137_1	415426.Hbut_0832	5.274e-147	479.0	COG0064@1|root,arCOG01718@2157|Archaea,2XQ1U@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
DTH3_k127_7349137_11	666510.ASAC_0761	2.984e-25	111.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
DTH3_k127_7349137_13	351160.RCIX2408	7.142e-22	101.0	COG0314@1|root,arCOG00533@2157|Archaea,2XVFP@28890|Euryarchaeota,2N9H4@224756|Methanomicrobia	224756|Methanomicrobia	H	MoaE protein	mobB	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,MobB
DTH3_k127_7349137_4	633148.Tagg_0998	3.336e-80	282.0	COG0144@1|root,arCOG00973@2157|Archaea,arCOG00975@2157|Archaea,2XPN6@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Fmu (Sun) domain protein	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,PUA
DTH3_k127_7349137_5	926692.AZYG01000086_gene736	9.01e-52	192.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,24D2S@186801|Clostridia,3WBYU@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
DTH3_k127_7349137_8	694429.Pyrfu_1064	2.615e-44	178.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_7359879_4	767817.Desgi_1425	7.049e-06	49.0	COG2271@1|root,COG2271@2|Bacteria,1UIF2@1239|Firmicutes,25EKE@186801|Clostridia,265TF@186807|Peptococcaceae	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH3_k127_7359879_0	525904.Tter_0750	3.043e-96	327.0	COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
DTH3_k127_7359879_2	195522.BD01_1077	3.525e-15	82.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,243RJ@183968|Thermococci	183968|Thermococci	O	Belongs to the small heat shock protein (HSP20) family	hsp20	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DTH3_k127_7359879_3	797302.Halru_2435	1.023e-14	84.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,23SEU@183963|Halobacteria	183963|Halobacteria	S	COG1938 Archaeal enzymes of ATP-grasp superfamily	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
DTH3_k127_7359879_1	1459636.NTE_00351	8.157e-28	124.0	COG1750@1|root,arCOG01937@2157|Archaea	2157|Archaea	S	Belongs to the peptidase S16 family	-	GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
DTH3_k127_7395810_1	1236689.MMALV_07510	1.304e-115	387.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,3F34R@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Archaeal Nre, N-terminal	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
DTH3_k127_7395810_4	446470.Snas_4283	0.0002965	53.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	phoA	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DTH3_k127_7395810_3	1459636.NTE_02437	8.223e-11	66.0	COG1552@1|root,arCOG04049@2157|Archaea,41T87@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	-	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
DTH3_k127_7395810_0	1459636.NTE_02820	1.322e-135	444.0	COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DTH3_k127_7395810_2	386456.JQKN01000019_gene1279	1.356e-23	106.0	COG0195@1|root,arCOG01761@2157|Archaea,2XWJU@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	KH_5
DTH3_k127_7399820_8	523850.TON_1343	2.203e-48	177.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,243RC@183968|Thermococci	183968|Thermococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
DTH3_k127_7399820_1	368408.Tpen_0497	1.307e-180	587.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
DTH3_k127_7399820_12	694429.Pyrfu_0369	1.378e-10	69.0	arCOG00552@1|root,arCOG00552@2157|Archaea,2XR6J@28889|Crenarchaeota	28889|Crenarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
DTH3_k127_7399820_7	589924.Ferp_1683	6.284e-59	221.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi	183980|Archaeoglobi	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_7399820_4	1009370.ALO_19767	6.984e-96	321.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,4H2FP@909932|Negativicutes	909932|Negativicutes	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	pyrK_1	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DTH3_k127_7399820_2	340099.Teth39_0216	1.073e-173	556.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
DTH3_k127_7399820_11	1229909.NSED_08180	1.684e-13	73.0	COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
DTH3_k127_7399820_0	697281.Mahau_0316	9.754e-195	616.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,42FA1@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DTH3_k127_7399820_3	933801.Ahos_0518	1.204e-113	375.0	COG0470@1|root,arCOG00469@2157|Archaea,2XPQ0@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rep_fac_C,RuvB_N
DTH3_k127_7399820_5	399550.Smar_1224	1.234e-90	312.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
DTH3_k127_7399820_14	1173024.KI912153_gene51	0.0001915	51.0	COG2405@1|root,COG2405@2|Bacteria,1G5DX@1117|Cyanobacteria	1117|Cyanobacteria	S	nucleic acid-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
DTH3_k127_7399820_13	1114856.C496_20020	7.181e-05	52.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2XYVJ@28890|Euryarchaeota,23WZG@183963|Halobacteria	183963|Halobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
DTH3_k127_7399820_9	436308.Nmar_1783	4.349e-40	158.0	COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Ser thr protein kinase	-	-	-	ko:K07176	-	-	-	-	ko00000	-	-	-	RIO1
DTH3_k127_7399820_6	868131.MSWAN_0911	4.871e-80	284.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23NVX@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
DTH3_k127_7399820_10	1123073.KB899245_gene96	1.043e-19	103.0	COG1361@1|root,COG3210@1|root,COG4733@1|root,COG5272@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria,COG5272@2|Bacteria	2|Bacteria	O	ubiquitin	-	-	-	ko:K02927,ko:K20276	ko02024,ko03010,map02024,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Autotransporter,Calx-beta,ubiquitin
DTH3_k127_7400096_4	673860.AciM339_0825	8.85e-38	148.0	COG2094@1|root,arCOG04295@2157|Archaea,2Y0AE@28890|Euryarchaeota,3F2UP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Belongs to the DNA glycosylase MPG family	mpg	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
DTH3_k127_7400096_11	1195246.AGRI_00815	4.097e-06	57.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,4663C@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
DTH3_k127_7400096_7	192952.MM_1639	4.21e-20	95.0	COG0110@1|root,arCOG01850@2157|Archaea,2XWH3@28890|Euryarchaeota,2NAQ8@224756|Methanomicrobia	224756|Methanomicrobia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
DTH3_k127_7400096_6	402880.MmarC5_0573	2.106e-20	104.0	COG1361@1|root,arCOG02079@2157|Archaea,2XV4F@28890|Euryarchaeota,23QFD@183939|Methanococci	183939|Methanococci	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7400096_1	868131.MSWAN_2252	2.03e-70	250.0	COG1131@1|root,arCOG00194@2157|Archaea,2XTJV@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DTH3_k127_7400096_10	903818.KI912268_gene1703	2.971e-11	75.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	ybhR	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DTH3_k127_7400096_8	1216966.BAUC01000005_gene1891	2.264e-17	94.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type multidrug transport system, permease component	ybhS	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
DTH3_k127_7400096_0	1286171.EAL2_808p06950	5.707e-121	400.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25VAD@186806|Eubacteriaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	aspC	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH3_k127_7400096_3	1232453.BAIF02000031_gene2557	1.869e-42	169.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH3_k127_7400096_2	368408.Tpen_1553	1.655e-62	224.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPVK@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran
DTH3_k127_7400096_5	667014.Thein_0487	1.035e-29	128.0	COG0555@1|root,COG0555@2|Bacteria,2GI4G@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
DTH3_k127_7400096_9	1365176.N186_02670	9.155e-17	89.0	arCOG03119@1|root,arCOG03119@2157|Archaea,2XQUD@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DTH3_k127_7400096_12	1122216.AUHW01000004_gene1626	1.595e-05	48.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,4H2RG@909932|Negativicutes	909932|Negativicutes	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
DTH3_k127_7446749_8	523845.AQXV01000051_gene1229	0.0002263	45.0	COG1531@1|root,arCOG01302@2157|Archaea,2Y015@28890|Euryarchaeota,23R8W@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
DTH3_k127_7446749_2	694429.Pyrfu_0204	1.406e-57	207.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQG7@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB1	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DTH3_k127_7446749_0	694429.Pyrfu_0840	1.031e-96	327.0	COG0731@1|root,arCOG04174@2157|Archaea,2XPM3@28889|Crenarchaeota	28889|Crenarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
DTH3_k127_7446749_5	1365176.N186_04700	1.188e-30	129.0	COG2178@1|root,arCOG04318@2157|Archaea,2XQKT@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
DTH3_k127_7446749_3	1196095.GAPWK_1534	1.916e-48	181.0	COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
DTH3_k127_7446749_4	589924.Ferp_0920	1.614e-42	165.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,245S3@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24
DTH3_k127_7446749_6	1220534.B655_2088	1.574e-25	111.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,23P3H@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
DTH3_k127_7446749_7	999630.TUZN_1850	4.961e-12	69.0	COG0615@1|root,COG1849@1|root,arCOG01222@2157|Archaea,arCOG01224@2157|Archaea,2XQ8K@28889|Crenarchaeota	28889|Crenarchaeota	M	TIGRFAM cytidyltransferase-related domain	-	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,DUF357
DTH3_k127_7446749_1	1041930.Mtc_2082	5.051e-67	237.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
DTH3_k127_7475224_12	1343739.PAP_07680	1.265e-56	208.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,24368@183968|Thermococci	183968|Thermococci	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
DTH3_k127_7475224_11	748727.CLJU_c37620	4.789e-64	226.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,36H5R@31979|Clostridiaceae	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS18525	MTHFR_C
DTH3_k127_7475224_8	1292035.H476_0413	2.415e-68	244.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,25R45@186804|Peptostreptococcaceae	186801|Clostridia	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
DTH3_k127_7475224_15	574087.Acear_0986	1.144e-50	189.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
DTH3_k127_7475224_25	1163730.FFONT_0808	3.354e-22	97.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
DTH3_k127_7475224_4	415426.Hbut_1178	4.174e-131	442.0	COG0018@1|root,arCOG00487@2157|Archaea,2XPXC@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DTH3_k127_7475224_20	1410624.JNKK01000001_gene590	1.262e-30	134.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,27IWA@186928|unclassified Lachnospiraceae	186801|Clostridia	K	ParB-like nuclease domain	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
DTH3_k127_7475224_16	1459636.NTE_03146	2.342e-44	168.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DTH3_k127_7475224_22	411468.CLOSCI_02828	2.845e-28	126.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,21YNG@1506553|Lachnoclostridium	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
DTH3_k127_7475224_2	868131.MSWAN_0996	8.15e-159	510.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,23NPK@183925|Methanobacteria	183925|Methanobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DTH3_k127_7475224_26	419665.Maeo_0931	5.071e-18	95.0	COG0620@1|root,arCOG01876@2157|Archaea,2XUCW@28890|Euryarchaeota,23QKE@183939|Methanococci	183939|Methanococci	E	PFAM Methionine synthase, vitamin-B12 independent	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
DTH3_k127_7475224_29	797209.ZOD2009_04637	8.485e-06	58.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVSG@28890|Euryarchaeota,23TS7@183963|Halobacteria	183963|Halobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
DTH3_k127_7475224_19	386456.JQKN01000005_gene515	8.819e-32	133.0	COG0746@1|root,arCOG01872@2157|Archaea,2XWJR@28890|Euryarchaeota,23PNI@183925|Methanobacteria	183925|Methanobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
DTH3_k127_7475224_27	1365176.N186_05755	2.088e-12	70.0	COG1826@1|root,arCOG02694@2157|Archaea,2XRB5@28889|Crenarchaeota	28889|Crenarchaeota	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
DTH3_k127_7475224_14	1220534.B655_0360	5.623e-51	192.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23NZ1@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
DTH3_k127_7475224_9	368408.Tpen_0880	1.145e-66	234.0	COG0149@1|root,arCOG01087@2157|Archaea,2XPYA@28889|Crenarchaeota	28889|Crenarchaeota	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
DTH3_k127_7475224_1	368408.Tpen_0196	7.147e-163	519.0	COG1980@1|root,arCOG04180@2157|Archaea,2XPV4@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	GO:0000287,GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016830,GO:0016832,GO:0019203,GO:0019318,GO:0019319,GO:0019362,GO:0019637,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0046483,GO:0046496,GO:0046872,GO:0050308,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901360,GO:1901564,GO:1901576	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
DTH3_k127_7475224_3	858215.Thexy_0814	8.875e-133	434.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,42F8D@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
DTH3_k127_7475224_17	1459636.NTE_03124	9.599e-41	164.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
DTH3_k127_7475224_5	374847.Kcr_1277	4.178e-128	424.0	COG2379@1|root,arCOG04170@2157|Archaea	2157|Archaea	G	Glycerate kinase	gck	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
DTH3_k127_7475224_6	374847.Kcr_1548	2.086e-115	381.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
DTH3_k127_7475224_10	401526.TcarDRAFT_2288	1.148e-64	229.0	COG1145@1|root,COG1145@2|Bacteria,1UIDU@1239|Firmicutes,4H7FN@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7475224_13	401526.TcarDRAFT_2289	4.497e-55	199.0	2AV93@1|root,31M00@2|Bacteria,1V94N@1239|Firmicutes,4H7KF@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7475224_21	374847.Kcr_0276	5.724e-30	125.0	COG1142@1|root,arCOG01502@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	porF	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_9
DTH3_k127_7475224_30	768672.Desfe_0694	1.43e-05	51.0	COG1977@1|root,arCOG00536@2157|Archaea,2XRHB@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DTH3_k127_7475224_0	1449126.JQKL01000016_gene2854	5.851e-196	629.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH3_k127_7475224_24	529709.PYCH_02430	3.143e-22	109.0	COG4346@1|root,arCOG00561@2157|Archaea,2XVUT@28890|Euryarchaeota,243GE@183968|Thermococci	183968|Thermococci	O	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT
DTH3_k127_7475224_23	1047013.AQSP01000047_gene2587	1.627e-23	106.0	COG0143@1|root,COG0143@2|Bacteria,2NNTX@2323|unclassified Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
DTH3_k127_7475224_28	224324.aq_1607	2.53e-06	56.0	COG0717@1|root,COG0717@2|Bacteria,2G4WK@200783|Aquificae	200783|Aquificae	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
DTH3_k127_7475224_31	572478.Vdis_0993	0.0007529	49.0	arCOG06011@1|root,arCOG06011@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
DTH3_k127_7475224_7	368408.Tpen_0574	1.816e-105	352.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
DTH3_k127_7475224_18	1219084.AP014508_gene1142	1.476e-40	158.0	COG0674@1|root,COG0674@2|Bacteria,2GC9T@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
DTH3_k127_7504445_0	350688.Clos_1108	4.45e-20	100.0	COG0535@1|root,COG0535@2|Bacteria,1V0CR@1239|Firmicutes,24BIB@186801|Clostridia,36G4D@31979|Clostridiaceae	186801|Clostridia	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
DTH3_k127_7504445_1	485913.Krac_10107	2.798e-19	97.0	COG2120@1|root,COG2120@2|Bacteria,2G6YU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
DTH3_k127_7504445_2	339860.Msp_0606	0.0001292	54.0	arCOG02487@1|root,arCOG02547@1|root,arCOG03671@1|root,arCOG02487@2157|Archaea,arCOG02547@2157|Archaea,arCOG03671@2157|Archaea	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,CarboxypepD_reg,Thermopsin
DTH3_k127_7527202_0	1382306.JNIM01000001_gene2320	7.668e-142	469.0	COG1123@1|root,COG4172@2|Bacteria,2GBJ7@200795|Chloroflexi	2|Bacteria	P	COGs COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase	-	-	3.6.3.24	ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16784,ko:K16786,ko:K16787	ko02010,ko02024,map02010,map02024	M00239,M00440,M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5	-	-	ABC_tran
DTH3_k127_7527202_2	1382306.JNIM01000001_gene2321	7.158e-36	147.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
DTH3_k127_7527202_1	768710.DesyoDRAFT_4824	1.924e-45	177.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24CK1@186801|Clostridia,25ZYG@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
DTH3_k127_7558219_0	159749.K0T6C5	1.105e-320	1013.0	COG2801@1|root,KOG0017@2759|Eukaryota,2XF4I@2836|Bacillariophyta	159749.K0T6C5|-	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7596303_5	28532.XP_010542602.1	1.197e-16	83.0	COG1269@1|root,KOG2189@2759|Eukaryota,37IDS@33090|Viridiplantae,3G7Z9@35493|Streptophyta,3HY5E@3699|Brassicales	35493|Streptophyta	C	Essential component of the vacuolar proton pump (V- ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase	-	GO:0000139,GO:0000325,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005773,GO:0005774,GO:0005794,GO:0005798,GO:0005802,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012505,GO:0012506,GO:0012510,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016043,GO:0016462,GO:0016469,GO:0016471,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022607,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030133,GO:0030135,GO:0030136,GO:0030140,GO:0030641,GO:0030658,GO:0030659,GO:0030660,GO:0030662,GO:0030665,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032588,GO:0032991,GO:0033176,GO:0034220,GO:0034622,GO:0034641,GO:0034654,GO:0036442,GO:0042470,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048770,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065003,GO:0065007,GO:0065008,GO:0070070,GO:0070071,GO:0070072,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0097708,GO:0098588,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098791,GO:0098796,GO:0098805,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02154	ko00190,ko01100,ko04142,ko04145,ko04721,ko04966,ko05110,ko05120,ko05152,ko05165,ko05323,map00190,map01100,map04142,map04145,map04721,map04966,map05110,map05120,map05152,map05165,map05323	M00160	-	-	ko00000,ko00001,ko00002,ko04147	3.A.2.2	-	-	V_ATPase_I
DTH3_k127_7596303_8	1499967.BAYZ01000009_gene5287	4.012e-06	53.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
DTH3_k127_7596303_6	339860.Msp_1137	7.737e-13	80.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,23NMG@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DTH3_k127_7596303_7	342949.PNA2_0834	3.25e-06	59.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2432C@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
DTH3_k127_7596303_3	255470.cbdbA1054	3.624e-78	269.0	COG0070@1|root,COG0070@2|Bacteria,2GAN8@200795|Chloroflexi,34CUP@301297|Dehalococcoidia	301297|Dehalococcoidia	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
DTH3_k127_7596303_0	387631.Asulf_00011	6.221e-229	720.0	COG0069@1|root,arCOG00619@2157|Archaea,2Y7H6@28890|Euryarchaeota,245Q2@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Glu_syn_central,Glu_synthase
DTH3_k127_7596303_1	552811.Dehly_0989	5.112e-153	491.0	COG0067@1|root,COG0067@2|Bacteria,2GAS0@200795|Chloroflexi,34D79@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2
DTH3_k127_7596303_2	552811.Dehly_0990	7.091e-114	381.0	COG1251@1|root,COG1251@2|Bacteria,2G6YZ@200795|Chloroflexi,34D0M@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
DTH3_k127_7596303_4	552811.Dehly_0992	9.271e-53	192.0	COG1142@1|root,COG1142@2|Bacteria,2GAMK@200795|Chloroflexi,34CSF@301297|Dehalococcoidia	301297|Dehalococcoidia	C	4Fe-4S dicluster domain	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4,Fer4_11
DTH3_k127_7596303_9	1487953.JMKF01000078_gene4100	0.0004585	44.0	COG0028@1|root,COG0028@2|Bacteria,1G17K@1117|Cyanobacteria,1H7E4@1150|Oscillatoriales	1117|Cyanobacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N,zinc_ribbon_2
DTH3_k127_7639821_3	593750.Metfor_1718	1.661e-107	359.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,2N93F@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0200	CdhD
DTH3_k127_7639821_1	593750.Metfor_1719	7.011e-195	617.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	cdhC	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
DTH3_k127_7639821_9	1220534.B655_0325	6.342e-73	254.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota	28890|Euryarchaeota	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
DTH3_k127_7639821_11	671143.DAMO_0462	2.321e-62	225.0	COG0189@1|root,COG0189@2|Bacteria,2NNM4@2323|unclassified Bacteria	2|Bacteria	HJ	Belongs to the RimK family	-	-	6.3.2.43	ko:K05827,ko:K05844	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	GSH-S_N,RimK
DTH3_k127_7639821_13	386456.JQKN01000001_gene2134	2.109e-40	161.0	COG4071@1|root,arCOG02715@2157|Archaea,2XUMN@28890|Euryarchaeota,23NY6@183925|Methanobacteria	183925|Methanobacteria	H	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
DTH3_k127_7639821_10	877455.Metbo_1082	8.843e-63	227.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,23P0Y@183925|Methanobacteria	183925|Methanobacteria	H	ATP dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
DTH3_k127_7639821_12	386456.JQKN01000016_gene901	1.848e-41	166.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
DTH3_k127_7639821_4	573063.Metin_0870	2.938e-97	326.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,23Q6M@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
DTH3_k127_7639821_5	589924.Ferp_1018	1.429e-91	309.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
DTH3_k127_7639821_15	1105031.HMPREF1141_1232	1.174e-11	71.0	COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia,36K5V@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
DTH3_k127_7639821_8	697281.Mahau_0475	2.059e-74	259.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
DTH3_k127_7639821_6	868595.Desca_2548	5.395e-87	298.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
DTH3_k127_7639821_7	1286171.EAL2_c10130	7.338e-78	270.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,25V3K@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
DTH3_k127_7639821_14	323259.Mhun_1984	3.069e-25	110.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
DTH3_k127_7639821_2	644281.MFS40622_0826	1.061e-143	467.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,23Q0U@183939|Methanococci	183939|Methanococci	C	TIGRFAM formylmethanofuran dehydrogenase subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
DTH3_k127_7639821_0	573064.Mefer_0155	3.712e-196	626.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,23QNZ@183939|Methanococci	183939|Methanococci	C	PFAM Amidohydrolase 3	fwdA	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
DTH3_k127_7639821_16	368407.Memar_0370	6.788e-11	66.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2N9RN@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	fwdC-1	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
DTH3_k127_7641821_7	634498.mru_1734	4.461e-05	47.0	COG2457@1|root,arCOG04458@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
DTH3_k127_7641821_4	1343739.PAP_03140	3.364e-15	81.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
DTH3_k127_7641821_0	391623.TERMP_00503	6.154e-94	316.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
DTH3_k127_7641821_5	386456.JQKN01000002_gene2858	6.032e-15	80.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y0XZ@28890|Euryarchaeota,23P6V@183925|Methanobacteria	183925|Methanobacteria	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
DTH3_k127_7641821_6	342949.PNA2_1154	5.186e-08	58.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,244JC@183968|Thermococci	183968|Thermococci	J	rRNA binding	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
DTH3_k127_7641821_2	1365176.N186_03345	2.532e-51	189.0	COG1976@1|root,arCOG04176@2157|Archaea,2XQJ0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
DTH3_k127_7641821_1	696369.KI912183_gene1363	8.649e-56	205.0	2DBZQ@1|root,2ZC2Y@2|Bacteria,1V2KN@1239|Firmicutes,24G8V@186801|Clostridia,261UW@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7641821_3	565033.GACE_0493	6.941e-43	167.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y7SU@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH3_k127_7667036_18	543526.Htur_2542	6.915e-09	62.0	COG1992@1|root,arCOG00021@2157|Archaea,2XTP7@28890|Euryarchaeota,23SNG@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN2	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
DTH3_k127_7667036_2	1121472.AQWN01000007_gene1075	1.022e-90	310.0	COG2309@1|root,COG2309@2|Bacteria,1UMYG@1239|Firmicutes,24BYI@186801|Clostridia,266UN@186807|Peptococcaceae	186801|Clostridia	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
DTH3_k127_7667036_0	868131.MSWAN_1972	2.852e-242	762.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,23NK7@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
DTH3_k127_7667036_1	342949.PNA2_0837	4.125e-226	707.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DTH3_k127_7667036_9	529709.PYCH_15760	7.332e-41	158.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,242NT@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
DTH3_k127_7667036_19	272557.APE_0198.1	3.122e-06	55.0	COG1308@1|root,arCOG04061@2157|Archaea,2XR2D@28889|Crenarchaeota	28889|Crenarchaeota	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
DTH3_k127_7667036_12	877455.Metbo_2057	2.398e-33	143.0	COG0842@1|root,arCOG01463@2157|Archaea,2XWB7@28890|Euryarchaeota,23PY9@183925|Methanobacteria	183925|Methanobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DTH3_k127_7667036_7	693661.Arcve_1732	2.955e-50	203.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DTH3_k127_7667036_17	1120949.KB903316_gene74	1.636e-10	74.0	COG1404@1|root,COG3506@1|root,COG1404@2|Bacteria,COG3506@2|Bacteria,2I8MD@201174|Actinobacteria,4DM2S@85008|Micromonosporales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8,SLH,fn3_5
DTH3_k127_7667036_13	572546.Arcpr_0261	1.607e-31	129.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2471G@183980|Archaeoglobi	183980|Archaeoglobi	O	PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
DTH3_k127_7667036_15	1094980.Mpsy_2073	6.819e-20	96.0	COG1813@1|root,arCOG01863@2157|Archaea,2XYZ0@28890|Euryarchaeota,2N9WA@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
DTH3_k127_7667036_5	415426.Hbut_1137	4.826e-53	192.0	COG1303@1|root,arCOG01857@2157|Archaea,2XQAA@28889|Crenarchaeota	28889|Crenarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
DTH3_k127_7667036_10	195522.BD01_1951	8.935e-40	154.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2438P@183968|Thermococci	183968|Thermococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
DTH3_k127_7667036_6	1089553.Tph_c27670	9.786e-52	190.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548,ko:K14084	ko00270,ko00450,ko00670,ko00680,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map01100,map01110,map01120,map01200,map01230	M00017,M00563	R00946,R09124,R09365	RC00035,RC00113,RC00732,RC01241,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
DTH3_k127_7667036_3	1282876.BAOK01000001_gene3616	4.572e-80	280.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,4BSFK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	MA20_31690	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
DTH3_k127_7667036_8	243232.MJ_0778	7.908e-43	163.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota,23R1B@183939|Methanococci	183939|Methanococci	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
DTH3_k127_7667036_11	391623.TERMP_01551	8.132e-35	143.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
DTH3_k127_7667036_14	410358.Mlab_0946	8.673e-28	122.0	arCOG02879@1|root,arCOG02879@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF4013)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4013
DTH3_k127_7667036_4	1229909.NSED_02900	4.399e-54	192.0	COG0432@1|root,arCOG04214@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
DTH3_k127_7667036_16	1122128.AUEE01000009_gene1446	4.83e-15	76.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,4GXQU@90964|Staphylococcaceae	91061|Bacilli	C	Isocitrate dehydrogenase NADP	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DTH3_k127_7678432_25	665571.STHERM_c15490	3.469e-07	58.0	2E8ZQ@1|root,33397@2|Bacteria,2J942@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7678432_3	555079.Toce_2249	1.445e-181	579.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,42FH5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
DTH3_k127_7678432_8	1459636.NTE_02880	7.241e-95	322.0	COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DTH3_k127_7678432_14	269797.Mbar_A3125	1.107e-46	172.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
DTH3_k127_7678432_4	868131.MSWAN_0509	1.05e-130	432.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23NJB@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
DTH3_k127_7678432_0	1449126.JQKL01000015_gene2926	2.491e-209	674.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,267K1@186813|unclassified Clostridiales	186801|Clostridia	F	AIR synthase related protein, C-terminal domain	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
DTH3_k127_7678432_11	192952.MM_2807	5.366e-79	269.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,2N9HC@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
DTH3_k127_7678432_22	1459636.NTE_01997	1.287e-18	89.0	COG1828@1|root,arCOG04462@2157|Archaea,41STY@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
DTH3_k127_7678432_13	1094980.Mpsy_0913	2.183e-51	192.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
DTH3_k127_7678432_24	1459636.NTE_02170	4.086e-08	60.0	COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7678432_2	247490.KSU1_D0718	3.467e-203	662.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
DTH3_k127_7678432_15	1047013.AQSP01000115_gene356	1.848e-42	179.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
DTH3_k127_7678432_9	593750.Metfor_2560	9.368e-93	313.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
DTH3_k127_7678432_17	342949.PNA2_1862	6.321e-35	137.0	COG0251@1|root,arCOG01630@2157|Archaea,2XXUZ@28890|Euryarchaeota,244C0@183968|Thermococci	183968|Thermococci	J	Endoribonuclease L-PSP	-	GO:0003674,GO:0003824,GO:0016787,GO:0019239	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
DTH3_k127_7678432_19	1131266.ARWQ01000002_gene497	6.888e-29	117.0	COG0760@1|root,arCOG07441@2157|Archaea,41SSK@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
DTH3_k127_7678432_26	351160.RCIX663	0.0002209	47.0	COG1763@1|root,arCOG00532@2157|Archaea	2157|Archaea	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	2.8.1.12	ko:K03635,ko:K03753	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	FeS,MobB
DTH3_k127_7678432_23	591019.Shell_0769	7.311e-10	63.0	COG2388@1|root,arCOG03647@2157|Archaea,2XR3B@28889|Crenarchaeota	28889|Crenarchaeota	S	GCN5-related N-acetyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7678432_5	247490.KSU1_D0451	5.199e-121	398.0	COG1899@1|root,COG1899@2|Bacteria,2IY4N@203682|Planctomycetes	203682|Planctomycetes	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
DTH3_k127_7678432_12	1229909.NSED_09885	4.157e-63	225.0	COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
DTH3_k127_7678432_18	1094980.Mpsy_1791	1.42e-32	144.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
DTH3_k127_7678432_6	589924.Ferp_0652	7.13e-104	348.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
DTH3_k127_7678432_1	351160.RCIX231	9.282e-206	673.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
DTH3_k127_7678432_20	696281.Desru_1598	1.371e-26	114.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,262ZF@186807|Peptococcaceae	186801|Clostridia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DTH3_k127_7678432_10	478749.BRYFOR_08002	2.968e-84	291.0	COG2220@1|root,COG2220@2|Bacteria,1TSFV@1239|Firmicutes,249MG@186801|Clostridia	186801|Clostridia	S	Beta-lactamase superfamily domain	ulaG	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactamase_B_2,Lactamase_B_3
DTH3_k127_7678432_21	1365176.N186_07420	1.975e-21	100.0	COG2606@1|root,arCOG04332@2157|Archaea	2157|Archaea	S	YbaK prolyl-tRNA synthetase associated	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
DTH3_k127_7678432_7	391623.TERMP_00332	2.066e-102	348.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DTH3_k127_7678432_16	1184251.TCELL_0576	1.879e-37	142.0	COG1530@1|root,arCOG00321@2157|Archaea,2XQ33@28889|Crenarchaeota	28889|Crenarchaeota	L	peptidase U62, modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DTH3_k127_7694507_1	639282.DEFDS_1816	2.564e-136	445.0	COG0282@1|root,COG0282@2|Bacteria,2GF56@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
DTH3_k127_7694507_0	436308.Nmar_1407	3.668e-139	451.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
DTH3_k127_7694507_2	415426.Hbut_0960	1.501e-77	270.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
DTH3_k127_7760163_2	1365176.N186_05185	5.714e-38	154.0	COG1829@1|root,arCOG04263@2157|Archaea,2XQG1@28889|Crenarchaeota	28889|Crenarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
DTH3_k127_7760163_4	243164.DET1403	1.236e-16	93.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
DTH3_k127_7760163_6	195522.BD01_0509	7.657e-09	64.0	COG3363@1|root,arCOG04727@2157|Archaea,2XTEV@28890|Euryarchaeota,243RW@183968|Thermococci	183968|Thermococci	F	Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP	purO	-	3.5.4.10	ko:K11176	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R01127	RC00456	ko00000,ko00001,ko00002,ko01000	-	-	-	IMP_cyclohyd
DTH3_k127_7760163_1	457415.HMPREF1006_01226	3.259e-49	183.0	COG2109@1|root,COG2109@2|Bacteria,3TB75@508458|Synergistetes	508458|Synergistetes	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
DTH3_k127_7760163_3	436308.Nmar_0617	2.119e-34	138.0	COG2042@1|root,arCOG04733@2157|Archaea,41SMC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Ribosome biogenesis protein, C-terminal	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
DTH3_k127_7760163_0	933801.Ahos_2288	2.537e-145	477.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
DTH3_k127_7760163_5	1163730.FFONT_0808	6.372e-16	78.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
DTH3_k127_7837845_0	1089553.Tph_c23940	2.307e-77	270.0	COG0167@1|root,COG1149@1|root,COG0167@2|Bacteria,COG1149@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,42FY6@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1,1.3.98.1	ko:K00226,ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
DTH3_k127_7837845_1	1298920.KI911353_gene4460	1.455e-63	225.0	COG0500@1|root,COG2226@2|Bacteria,1UVHG@1239|Firmicutes,25KIB@186801|Clostridia,221KJ@1506553|Lachnoclostridium	186801|Clostridia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DTH3_k127_7879309_3	673860.AciM339_0625	1.565e-39	154.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2Y8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DTH3_k127_7879309_5	768679.TTX_1480	1.725e-14	77.0	COG4352@1|root,arCOG01013@2157|Archaea,2XRIE@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL13 family	rpl13e	-	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e,Ribosomal_L15e
DTH3_k127_7879309_2	591019.Shell_1617	3.707e-41	156.0	COG1632@1|root,arCOG04209@2157|Archaea,2XPQ8@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
DTH3_k127_7879309_4	195522.BD01_0968	3.043e-17	85.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
DTH3_k127_7879309_0	420247.Msm_0655	5.508e-111	372.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DTH3_k127_7879309_1	877455.Metbo_2292	7.727e-80	278.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23NRF@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DTH3_k127_7897456_0	1163671.JAGI01000003_gene514	1.604e-244	777.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,249KX@186801|Clostridia,36H4W@31979|Clostridiaceae	186801|Clostridia	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
DTH3_k127_7897456_3	580327.Tthe_1946	4.268e-57	205.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia	186801|Clostridia	P	domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DTH3_k127_7897456_4	1120746.CCNL01000010_gene1351	1.391e-25	111.0	COG0569@1|root,COG0569@2|Bacteria,2NPN3@2323|unclassified Bacteria	2|Bacteria	P	TrkA-C domain	trkA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DTH3_k127_7897456_5	1304885.AUEY01000026_gene3577	6.707e-07	57.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	gloA	-	3.2.2.1	ko:K01239,ko:K08234	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
DTH3_k127_7897456_2	696369.KI912183_gene1157	3.734e-85	296.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19954	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
DTH3_k127_7897456_1	1123371.ATXH01000001_gene1323	8.172e-129	432.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GH97@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Succinyl-CoA ligase like flavodoxin domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
DTH3_k127_7898306_0	224325.AF_1199	1.11e-129	421.0	COG1788@1|root,arCOG01987@2157|Archaea,2XVRA@28890|Euryarchaeota,246WP@183980|Archaeoglobi	183980|Archaeoglobi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
DTH3_k127_7898306_3	358396.C445_18396	1.669e-96	322.0	COG2057@1|root,arCOG05316@2157|Archaea,2XW2C@28890|Euryarchaeota,23U50@183963|Halobacteria	183963|Halobacteria	I	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
DTH3_k127_7898306_8	523850.TON_1386	2.515e-29	131.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EI@28890|Euryarchaeota,242RF@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DTH3_k127_7898306_2	710696.Intca_3130	3.284e-100	340.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FJQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
DTH3_k127_7898306_6	945713.IALB_2866	1.351e-49	180.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yiiD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K06323	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,YiiD_C
DTH3_k127_7898306_9	247490.KSU1_C0904	5.517e-17	88.0	COG0170@1|root,COG0560@1|root,COG0170@2|Bacteria,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	cdsA_1	-	3.1.3.3	ko:K01079,ko:K05967,ko:K07025	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD,NT5C
DTH3_k127_7898306_5	309801.trd_0142	1.488e-76	269.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
DTH3_k127_7898306_4	1459636.NTE_03061	7.414e-78	268.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DTH3_k127_7898306_1	304371.MCP_2633	2.177e-111	370.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DTH3_k127_7898306_7	386456.JQKN01000011_gene787	2.598e-38	148.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota	28890|Euryarchaeota	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
DTH3_k127_7906628_10	1192034.CAP_5784	6.516e-38	149.0	COG1216@1|root,COG1216@2|Bacteria,1QX3U@1224|Proteobacteria,42RP8@68525|delta/epsilon subdivisions,2WNF5@28221|Deltaproteobacteria,2Z30X@29|Myxococcales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
DTH3_k127_7906628_2	930945.SiRe_1558	7.266e-67	238.0	COG0010@1|root,arCOG01700@2157|Archaea,2XQGD@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DTH3_k127_7906628_12	1346791.M529_21955	6.988e-28	131.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria,2KEB5@204457|Sphingomonadales	204457|Sphingomonadales	QU	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3,PD40
DTH3_k127_7906628_6	1236689.MMALV_14890	1.824e-51	197.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y696@28890|Euryarchaeota,3F2WC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
DTH3_k127_7906628_1	646529.Desaci_0969	1.502e-115	388.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,262B7@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
DTH3_k127_7906628_11	309801.trd_0144	6.561e-28	117.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
DTH3_k127_7906628_8	304371.MCP_2637	1.753e-46	171.0	COG3260@1|root,arCOG01553@2157|Archaea,2Y8IV@28890|Euryarchaeota,2NAU2@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.12.7.2	ko:K18023	-	-	R00019	-	ko00000,ko01000	-	-	-	Oxidored_q6
DTH3_k127_7906628_13	304371.MCP_2638	1.992e-24	112.0	COG1143@1|root,arCOG01543@2157|Archaea	2157|Archaea	C	Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I)	ehbL	-	1.1.98.4,1.12.98.1,1.17.1.9,1.8.4.10,1.8.4.8,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00123,ko:K00390,ko:K00441,ko:K03388,ko:K14121,ko:K22174	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	M00176,M00356,M00357,M00563,M00567	R00519,R02021,R03025,R04540,R11928,R11931,R11943,R11944	RC00007,RC00011,RC02628,RC02796,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_4,Fer4_7,PAPS_reduct
DTH3_k127_7906628_3	351160.RCIX481	4.692e-60	220.0	COG1005@1|root,arCOG01546@2157|Archaea,2XT7N@28890|Euryarchaeota,2N9XC@224756|Methanomicrobia	224756|Methanomicrobia	C	Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	fpoH	-	1.5.98.3,1.6.5.3	ko:K00337,ko:K22163	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	NADHdh
DTH3_k127_7906628_0	1041930.Mtc_0483	1.008e-120	407.0	COG0852@1|root,COG3261@1|root,arCOG01547@2157|Archaea,arCOG01551@2157|Archaea,2Y7K6@28890|Euryarchaeota,2N9MK@224756|Methanomicrobia	224756|Methanomicrobia	C	Membrane bound hydrogenase subunit	-	-	1.12.7.2	ko:K18016	-	-	R00019	-	ko00000,ko01000	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
DTH3_k127_7906628_7	1041930.Mtc_0296	1.627e-46	186.0	COG1009@1|root,arCOG01539@2157|Archaea,2Y85E@28890|Euryarchaeota,2NAU9@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	-	ko:K05565,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
DTH3_k127_7906628_14	304371.MCP_2641	0.0002145	49.0	arCOG13258@1|root,arCOG13258@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_7906628_4	523845.AQXV01000047_gene768	5.019e-54	202.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q7G@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
DTH3_k127_7906628_9	304371.MCP_2644	6.482e-39	150.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2NB5B@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_6
DTH3_k127_7906628_5	720554.Clocl_2569	1.574e-52	196.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,3WGKM@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
DTH3_k127_7959985_1	693661.Arcve_1241	2.553e-34	139.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,245QB@183980|Archaeoglobi	183980|Archaeoglobi	N	PFAM type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DTH3_k127_7959985_0	1144275.COCOR_02785	1.262e-46	186.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,42RE9@68525|delta/epsilon subdivisions,2WNSX@28221|Deltaproteobacteria,2YU8K@29|Myxococcales	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
DTH3_k127_7959985_2	1104324.P186_2360	5.79e-07	61.0	COG4346@1|root,arCOG09770@1|root,arCOG00561@2157|Archaea,arCOG09770@2157|Archaea	2157|Archaea	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT,PMT_2
DTH3_k127_8010623_5	713587.THITH_11280	3.286e-30	124.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,1S28T@1236|Gammaproteobacteria,1WY61@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
DTH3_k127_8010623_0	1499967.BAYZ01000069_gene1853	0.0	1055.0	COG0474@1|root,COG0474@2|Bacteria,2NNSC@2323|unclassified Bacteria	2|Bacteria	P	Cation transporter/ATPase, N-terminus	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
DTH3_k127_8010623_1	1459636.NTE_00936	5.994e-166	533.0	COG0151@1|root,arCOG04415@2157|Archaea	2157|Archaea	F	Belongs to the GARS family	purD1	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C
DTH3_k127_8010623_2	926560.KE387027_gene654	8.11e-80	289.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1WKH0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EU	PFAM Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
DTH3_k127_8010623_7	640511.BC1002_6762	9.194e-16	83.0	COG0071@1|root,COG0071@2|Bacteria,1RH6E@1224|Proteobacteria,2VRIE@28216|Betaproteobacteria,1K4NJ@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DTH3_k127_8010623_8	1390370.O203_14825	2.448e-13	82.0	COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,1RNR4@1236|Gammaproteobacteria,1YDPS@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	benK	-	-	ko:K05548	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4,Sugar_tr
DTH3_k127_8010623_3	877455.Metbo_1245	5.432e-46	178.0	COG0053@1|root,arCOG01475@2157|Archaea,2Y8CZ@28890|Euryarchaeota	28890|Euryarchaeota	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,Nitro_FeMo-Co,ZT_dimer
DTH3_k127_8010623_4	1229485.AMYV01000086_gene2751	1.195e-33	132.0	COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,1SF1D@1236|Gammaproteobacteria,1JBJF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
DTH3_k127_8010623_6	246969.TAM4_642	3.326e-19	99.0	COG2512@1|root,arCOG00374@2157|Archaea,2Y30F@28890|Euryarchaeota,243E6@183968|Thermococci	183968|Thermococci	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,TrmB
DTH3_k127_8010623_9	415426.Hbut_1079	6.458e-10	60.0	COG2835@1|root,arCOG04124@2157|Archaea,2XQTG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
DTH3_k127_8012381_1	634497.HAH_1210	3.237e-24	116.0	COG0438@1|root,arCOG01403@2157|Archaea,2XX52@28890|Euryarchaeota,23WDF@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
DTH3_k127_8012381_0	926561.KB900623_gene1000	1.836e-30	122.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,3WBY3@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
DTH3_k127_8012381_2	243164.DET0567	8.849e-19	89.0	COG1837@1|root,COG1837@2|Bacteria,2G7DU@200795|Chloroflexi,34DG8@301297|Dehalococcoidia	301297|Dehalococcoidia	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
DTH3_k127_8142_14	386456.JQKN01000002_gene2765	3.855e-09	59.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
DTH3_k127_8142_8	999630.TUZN_0370	1.318e-42	161.0	COG0500@1|root,arCOG01631@2157|Archaea,2XQ7P@28889|Crenarchaeota	28889|Crenarchaeota	Q	RNA methylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	CMAS,DOT1,Methyltransf_25,Methyltransf_31,PrmA
DTH3_k127_8142_4	1459636.NTE_00077	7.814e-80	279.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
DTH3_k127_8142_1	1122216.AUHW01000001_gene726	2.742e-105	357.0	COG2271@1|root,COG2271@2|Bacteria,1UHSG@1239|Firmicutes,4H22F@909932|Negativicutes	909932|Negativicutes	G	Transporter, major facilitator family protein	naiP	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,MFS_4,Sugar_tr
DTH3_k127_8142_13	374847.Kcr_0944	2.04e-12	76.0	arCOG02103@1|root,arCOG02103@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
DTH3_k127_8142_0	574087.Acear_0770	3.079e-107	362.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,3WAET@53433|Halanaerobiales	186801|Clostridia	HP	PFAM ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
DTH3_k127_8142_2	574087.Acear_0769	1.143e-95	324.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WAHZ@53433|Halanaerobiales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
DTH3_k127_8142_6	868131.MSWAN_0360	1.065e-74	265.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,23NX3@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
DTH3_k127_8142_5	1121430.JMLG01000001_gene2091	3.585e-78	276.0	COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,260RS@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
DTH3_k127_8142_7	1131266.ARWQ01000009_gene957	4.725e-63	228.0	COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
DTH3_k127_8142_3	572478.Vdis_0591	5.972e-88	306.0	COG2038@1|root,arCOG04272@2157|Archaea,2XQ64@28889|Crenarchaeota	28889|Crenarchaeota	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	DBI_PRT
DTH3_k127_8142_12	1423321.AS29_20980	1.31e-17	95.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,4HA28@91061|Bacilli,1ZASR@1386|Bacillus	91061|Bacilli	HP	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components	yvrA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran,CbiZ
DTH3_k127_8142_11	269797.Mbar_A3455	6.924e-30	132.0	COG1267@1|root,arCOG01869@2157|Archaea,2XZTX@28890|Euryarchaeota,2NA1N@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Phosphatidylglycerophosphatase A	-	-	-	-	-	-	-	-	-	-	-	-	PgpA
DTH3_k127_8142_10	1220534.B655_0041	9.803e-33	136.0	COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,23P3E@183925|Methanobacteria	183925|Methanobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
DTH3_k127_8142_9	386456.JQKN01000013_gene3046	3.305e-34	139.0	COG2266@1|root,arCOG01871@2157|Archaea,2XZP4@28890|Euryarchaeota,23P5D@183925|Methanobacteria	183925|Methanobacteria	M	Cytidylyltransferase	cobY	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
DTH3_k127_8142_15	386456.JQKN01000008_gene1353	0.0003295	51.0	COG0457@1|root,COG1266@1|root,arCOG02769@2157|Archaea,arCOG03045@2157|Archaea,2XYZF@28890|Euryarchaeota	28890|Euryarchaeota	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi,TPR_12
DTH3_k127_8215678_4	644281.MFS40622_1443	1.972e-31	126.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,23QUS@183939|Methanococci	183939|Methanococci	C	TIGRFAM archaeoflavoprotein AfpA	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
DTH3_k127_8215678_3	521011.Mpal_2448	1.737e-50	187.0	COG0463@1|root,arCOG01381@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
DTH3_k127_8215678_1	868595.Desca_0924	1.664e-96	325.0	COG0535@1|root,COG0535@2|Bacteria,1TPZ4@1239|Firmicutes,249UR@186801|Clostridia,2606I@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
DTH3_k127_8215678_5	1104324.P186_2618	1.74e-29	130.0	COG0668@1|root,arCOG01568@2157|Archaea,2XQVK@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM MscS Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
DTH3_k127_8215678_0	1459636.NTE_00007	1.772e-183	599.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
DTH3_k127_8215678_7	880072.Desac_2172	8.974e-07	54.0	arCOG07300@1|root,2ZTGG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8215678_6	109760.SPPG_05895T0	6.53e-08	63.0	COG0468@1|root,KOG1434@2759|Eukaryota,39J83@33154|Opisthokonta,3NVB0@4751|Fungi	4751|Fungi	L	Belongs to the RecA family	-	GO:0000003,GO:0000018,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000709,GO:0000724,GO:0000725,GO:0000730,GO:0000793,GO:0000794,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006311,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007130,GO:0007131,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010520,GO:0010564,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022402,GO:0022414,GO:0022607,GO:0030554,GO:0031323,GO:0031974,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0033043,GO:0033554,GO:0034622,GO:0034641,GO:0035639,GO:0035822,GO:0035825,GO:0036094,GO:0040020,GO:0042148,GO:0042623,GO:0042802,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044877,GO:0045003,GO:0045132,GO:0045143,GO:0046483,GO:0048285,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051128,GO:0051171,GO:0051259,GO:0051260,GO:0051276,GO:0051321,GO:0051445,GO:0051716,GO:0051726,GO:0051783,GO:0060255,GO:0060631,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070192,GO:0070193,GO:0071704,GO:0071824,GO:0071840,GO:0080090,GO:0090304,GO:0090735,GO:0097159,GO:0097367,GO:0098813,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1903046,GO:1905334,GO:2000241	-	ko:K10872,ko:K14545	ko03008,ko04113,map03008,map04113	-	-	-	ko00000,ko00001,ko03009,ko03400	-	-	-	HHH_5,Rad51
DTH3_k127_8215678_2	415426.Hbut_0909	1.864e-76	271.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
DTH3_k127_8226724_0	1184251.TCELL_1236	9.518e-73	248.0	COG0674@1|root,arCOG01608@2157|Archaea,2XPUZ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
DTH3_k127_8226724_2	1365176.N186_03215	4.704e-31	123.0	COG1144@1|root,arCOG01605@2157|Archaea,2XR7D@28889|Crenarchaeota	28889|Crenarchaeota	C	oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
DTH3_k127_8226724_1	1121459.AQXE01000010_gene1976	6.092e-52	189.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2M92T@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
DTH3_k127_8226724_3	591019.Shell_1488	1.957e-15	81.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2XSGW@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8227536_3	572546.Arcpr_1848	2.674e-32	128.0	COG0410@1|root,arCOG00924@2157|Archaea,2XT1R@28890|Euryarchaeota,245VS@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DTH3_k127_8227536_0	374847.Kcr_0826	3.287e-70	245.0	COG0411@1|root,arCOG00926@2157|Archaea	2157|Archaea	E	COG0411 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DTH3_k127_8227536_1	572546.Arcpr_1846	4.747e-53	199.0	COG4177@1|root,arCOG01274@2157|Archaea,2XW08@28890|Euryarchaeota,2463K@183980|Archaeoglobi	183980|Archaeoglobi	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH3_k127_8227536_2	1037409.BJ6T_15790	2.549e-40	160.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,3JS3Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DTH3_k127_8277667_3	868131.MSWAN_1997	0.0008483	42.0	COG4912@1|root,arCOG05122@2157|Archaea,2Y8HF@28890|Euryarchaeota,23PXI@183925|Methanobacteria	183925|Methanobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
DTH3_k127_8277667_1	234267.Acid_1471	9.563e-67	237.0	COG0491@1|root,COG0491@2|Bacteria,3Y83W@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH3_k127_8277667_0	595494.Tola_1404	3.29e-104	343.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DTH3_k127_8277667_2	1121456.ATVA01000013_gene1127	1.176e-09	61.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2M8Q4@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DTH3_k127_8284585_1	311424.DhcVS_121	5.044e-80	279.0	COG1740@1|root,COG1740@2|Bacteria,2G6Y3@200795|Chloroflexi,34D71@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	hupS	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
DTH3_k127_8284585_5	304371.MCP_0374	4.927e-30	125.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0UT@28890|Euryarchaeota,2NB7J@224756|Methanomicrobia	224756|Methanomicrobia	C	Hydrogenase maturation protease	vhtD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
DTH3_k127_8284585_3	521045.Kole_1017	7.213e-46	180.0	COG0642@1|root,COG2205@2|Bacteria	521045.Kole_1017|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8284585_7	760568.Desku_1178	1.877e-24	114.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DTH3_k127_8284585_6	555079.Toce_0967	2.159e-27	116.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DTH3_k127_8284585_9	47716.JOFH01000029_gene3194	1.345e-18	98.0	COG0726@1|root,COG1215@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Polysacc_deac_1
DTH3_k127_8284585_11	404589.Anae109_2408	9.611e-08	60.0	28JYU@1|root,2Z9NZ@2|Bacteria,1N5J2@1224|Proteobacteria,42UJJ@68525|delta/epsilon subdivisions,2X7XY@28221|Deltaproteobacteria,2Z2S3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8284585_0	706587.Desti_3013	2.654e-88	316.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N9U@68525|delta/epsilon subdivisions,2WINY@28221|Deltaproteobacteria	1224|Proteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
DTH3_k127_8284585_8	713586.KB900536_gene1017	1.255e-22	114.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria,1WW9H@135613|Chromatiales	135613|Chromatiales	C	PFAM Nitrate reductase gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
DTH3_k127_8284585_2	386456.JQKN01000002_gene2815	5.698e-73	262.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,23PFJ@183925|Methanobacteria	183925|Methanobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
DTH3_k127_8284585_10	268739.Nmlp_2958	4.922e-16	88.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,23SVZ@183963|Halobacteria	183963|Halobacteria	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	ubiA2	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
DTH3_k127_8284585_4	224325.AF_0175	1.88e-35	143.0	COG0437@1|root,arCOG01500@2157|Archaea,2XU83@28890|Euryarchaeota,246KB@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
DTH3_k127_8304762_0	269797.Mbar_A1749	1.211e-60	220.0	COG3359@1|root,arCOG03130@2157|Archaea,2XUES@28890|Euryarchaeota,2NANN@224756|Methanomicrobia	224756|Methanomicrobia	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
DTH3_k127_8304762_4	1048339.KB913029_gene5053	1.794e-06	59.0	COG2931@1|root,COG2931@2|Bacteria,2GKS7@201174|Actinobacteria,4EX57@85013|Frankiales	201174|Actinobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind,Peptidase_M91,fn3
DTH3_k127_8304762_2	221288.JH992901_gene3767	2.78e-41	167.0	COG0823@1|root,COG0823@2|Bacteria,1G8I3@1117|Cyanobacteria	1117|Cyanobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
DTH3_k127_8304762_1	521011.Mpal_0243	9.926e-59	216.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y29P@28890|Euryarchaeota,2NA5X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8304762_3	1041930.Mtc_2314	1.181e-07	54.0	arCOG10829@1|root,arCOG10829@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8355071_1	192952.MM_1485	2.243e-12	70.0	COG1534@1|root,arCOG01346@2157|Archaea	2157|Archaea	J	RNA-binding protein containing KH domain possibly ribosomal protein	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
DTH3_k127_8355071_0	247490.KSU1_C0752	1.551e-111	377.0	COG1488@1|root,COG1488@2|Bacteria,2IXDA@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
DTH3_k127_8420318_0	255470.cbdbA943	7.203e-133	432.0	COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia	301297|Dehalococcoidia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
DTH3_k127_8420318_3	273057.SSO0425	5.667e-05	50.0	COG4901@1|root,arCOG04327@2157|Archaea,2XRD4@28889|Crenarchaeota	28889|Crenarchaeota	J	S25 ribosomal protein	rps25e	-	-	ko:K02975	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S25
DTH3_k127_8420318_2	868131.MSWAN_0689	2.719e-15	80.0	COG2164@1|root,arCOG04488@2157|Archaea,2XXU6@28890|Euryarchaeota	28890|Euryarchaeota	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
DTH3_k127_8420318_1	386456.JQKN01000013_gene3004	2.108e-102	345.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
DTH3_k127_8464994_1	263820.PTO0840	1.532e-65	226.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,241JG@183967|Thermoplasmata	183967|Thermoplasmata	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DTH3_k127_8464994_5	696369.KI912183_gene91	1.109e-25	114.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,26214@186807|Peptococcaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
DTH3_k127_8464994_6	222984.JNCS01000003_gene2970	2.27e-17	90.0	arCOG04522@1|root,arCOG04522@2157|Archaea,2XTU5@28890|Euryarchaeota,23U1D@183963|Halobacteria	183963|Halobacteria	O	cytochrome c biogenesis protein	dsbD	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
DTH3_k127_8464994_3	269797.Mbar_A1392	6.721e-59	218.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,2N925@224756|Methanomicrobia	224756|Methanomicrobia	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
DTH3_k127_8464994_4	224325.AF_1068	1.024e-31	129.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,246DZ@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
DTH3_k127_8464994_2	415426.Hbut_0632	3.811e-61	220.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
DTH3_k127_8464994_7	671065.MetMK1DRAFT_00033040	6.941e-05	51.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8464994_0	694429.Pyrfu_0109	9.57e-119	391.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
DTH3_k127_8483674_1	1343739.PAP_07680	2.765e-41	158.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,24368@183968|Thermococci	183968|Thermococci	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
DTH3_k127_8483674_0	387631.Asulf_01966	9.877e-88	299.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2460U@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
DTH3_k127_8483674_2	1293054.HSACCH_00536	6.738e-23	104.0	COG2218@1|root,COG2218@2|Bacteria	2|Bacteria	C	formylmethanofuran dehydrogenase activity	fhcC	GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
DTH3_k127_8561911_1	665942.HMPREF1022_03266	6.589e-52	193.0	COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,42YUP@68525|delta/epsilon subdivisions,2WTS1@28221|Deltaproteobacteria,2MAPB@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DNA polymerase A domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A
DTH3_k127_8561911_2	488538.SAR116_0391	7.271e-41	156.0	COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase family A	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_A
DTH3_k127_8561911_0	438753.AZC_3598	2.939e-82	282.0	COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QT52@1224|Proteobacteria,2TVNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Toprim-like	-	-	3.6.4.12	ko:K17680	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	DnaB_C,Toprim_2
DTH3_k127_8567801_1	593750.Metfor_2079	4.118e-72	245.0	COG1117@1|root,arCOG00231@2157|Archaea,2XTJK@28890|Euryarchaeota,2N93D@224756|Methanomicrobia	224756|Methanomicrobia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DTH3_k127_8567801_2	1459636.NTE_00042	6.418e-42	162.0	COG0704@1|root,arCOG00232@2157|Archaea,41T42@651137|Thaumarchaeota	651137|Thaumarchaeota	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DTH3_k127_8567801_3	694431.DESACE_07530	9.574e-35	147.0	COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,43BPJ@68525|delta/epsilon subdivisions,2WK2H@28221|Deltaproteobacteria,2M6U1@213113|Desulfurellales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
DTH3_k127_8567801_4	368408.Tpen_0662	8.566e-17	81.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
DTH3_k127_8567801_5	1056495.Calag_1447	1.399e-14	79.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
DTH3_k127_8567801_0	330779.Saci_0773	2.221e-280	878.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
DTH3_k127_8567801_6	1459636.NTE_01660	1.479e-05	50.0	arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8591662_2	177439.DP2153	4.125e-14	76.0	2CG94@1|root,337GB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8591662_3	926550.CLDAP_20390	1.295e-12	80.0	COG2146@1|root,COG2146@2|Bacteria,2G7AG@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
DTH3_k127_8591662_1	304371.MCP_1733	1.216e-46	184.0	COG0655@1|root,COG1592@1|root,arCOG01097@2157|Archaea,arCOG02578@2157|Archaea	2157|Archaea	P	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Rubrerythrin
DTH3_k127_8591662_0	340099.Teth39_0287	2.699e-87	296.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DTH3_k127_8593306_1	485913.Krac_8495	1.367e-64	236.0	COG1143@1|root,COG2006@1|root,COG1143@2|Bacteria,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4_17,FrhB_FdhB_C
DTH3_k127_8593306_2	224325.AF_0601	4.789e-27	123.0	COG0500@1|root,arCOG01400@2157|Archaea,2Y0KF@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
DTH3_k127_8593306_3	1403819.BATR01000181_gene6162	1.919e-24	116.0	COG0438@1|root,COG0438@2|Bacteria,46WHJ@74201|Verrucomicrobia,2IVEA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DTH3_k127_8593306_0	645991.Sgly_0859	6.189e-92	312.0	COG0535@1|root,COG0535@2|Bacteria,1UXWS@1239|Firmicutes,247NG@186801|Clostridia	186801|Clostridia	C	Radical SAM	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
DTH3_k127_8599824_3	521011.Mpal_1638	0.0001561	44.0	COG0310@1|root,arCOG02248@2157|Archaea,2XTXA@28890|Euryarchaeota,2NAQR@224756|Methanomicrobia	224756|Methanomicrobia	P	Cobalt uptake substrate-specific transmembrane region	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
DTH3_k127_8599824_1	386456.JQKN01000008_gene1364	2.156e-36	141.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	nikR1	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
DTH3_k127_8599824_0	237368.SCABRO_03425	4.374e-66	233.0	COG0463@1|root,COG0463@2|Bacteria,2IZV0@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DTH3_k127_8599824_2	944562.HMPREF9102_1391	6.766e-16	87.0	COG3222@1|root,COG3222@2|Bacteria,1VANQ@1239|Firmicutes,4IFMA@91061|Bacilli,3F6PB@33958|Lactobacillaceae	91061|Bacilli	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2064
DTH3_k127_8652831_0	868131.MSWAN_1961	3.822e-129	426.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,23NMB@183925|Methanobacteria	183925|Methanobacteria	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
DTH3_k127_8652831_2	693661.Arcve_1029	9.6e-10	67.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
DTH3_k127_8652831_1	868131.MSWAN_2069	2.297e-17	83.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
DTH3_k127_8684981_3	1192034.CAP_2724	1.041e-65	229.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2YV73@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
DTH3_k127_8684981_0	1041930.Mtc_2296	6.119e-268	855.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
DTH3_k127_8684981_1	529709.PYCH_13670	3.045e-243	782.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,243PB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DTH3_k127_8684981_9	933801.Ahos_1298	1.672e-19	91.0	COG2058@1|root,arCOG04287@2157|Archaea,2XQSC@28889|Crenarchaeota	28889|Crenarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
DTH3_k127_8684981_4	1459636.NTE_00712	6.238e-61	220.0	COG0244@1|root,arCOG04288@2157|Archaea,41S9R@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
DTH3_k127_8684981_6	1365176.N186_01960	5.183e-55	199.0	COG0081@1|root,arCOG04289@2157|Archaea,2XQ8W@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DTH3_k127_8684981_5	877455.Metbo_2250	5.622e-57	202.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23NZG@183925|Methanobacteria	183925|Methanobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
DTH3_k127_8684981_8	186497.PF1990	8.768e-36	142.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2441S@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
DTH3_k127_8684981_11	490899.DKAM_1106	8.203e-06	51.0	COG2443@1|root,arCOG02204@2157|Archaea,2XR4B@28889|Crenarchaeota	28889|Crenarchaeota	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
DTH3_k127_8684981_7	593117.TGAM_0482	3.259e-49	185.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
DTH3_k127_8684981_2	70601.3257134	5.388e-91	306.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,242ZT@183968|Thermococci	183968|Thermococci	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DTH3_k127_8684981_10	1449126.JQKL01000030_gene2493	1.331e-07	55.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,26827@186813|unclassified Clostridiales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DTH3_k127_8781799_1	1125863.JAFN01000001_gene957	2.997e-05	47.0	COG2445@1|root,COG2445@2|Bacteria,1NX6S@1224|Proteobacteria,430RY@68525|delta/epsilon subdivisions,2WVSE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
DTH3_k127_8781799_0	335543.Sfum_1184	3.316e-167	541.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8861960_1	410358.Mlab_0997	7.051e-41	158.0	COG1392@1|root,arCOG02640@2157|Archaea	2157|Archaea	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
DTH3_k127_8861960_0	883.DvMF_2992	3.753e-255	810.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
DTH3_k127_8878120_0	572478.Vdis_0027	1.898e-53	202.0	COG2262@1|root,arCOG00353@2157|Archaea,2XQ0E@28889|Crenarchaeota	28889|Crenarchaeota	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
DTH3_k127_8955966_4	579137.Metvu_1353	3.399e-05	52.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_8955966_2	1179773.BN6_58260	2.219e-16	93.0	COG2234@1|root,COG3979@1|root,COG2234@2|Bacteria,COG3979@2|Bacteria,2GIT0@201174|Actinobacteria,4EFDV@85010|Pseudonocardiales	201174|Actinobacteria	O	Peptidase family M28	-	-	3.4.11.24	ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,P_proprotein,Peptidase_M28,Peptidase_M4,Peptidase_M4_C
DTH3_k127_8955966_3	1121381.JNIV01000007_gene2221	1.341e-08	63.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
DTH3_k127_8955966_0	694429.Pyrfu_1064	3.792e-46	183.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_8955966_1	272844.PAB2112	3.321e-33	136.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
DTH3_k127_8964399_1	483218.BACPEC_02838	9.765e-15	80.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,267WX@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
DTH3_k127_8964399_0	391623.TERMP_00652	8.276e-78	270.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
DTH3_k127_9001965_1	1365176.N186_01615	5.292e-19	93.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
DTH3_k127_9001965_0	351160.RCIX1621	3.597e-31	133.0	COG0725@1|root,arCOG00219@2157|Archaea,2XWT8@28890|Euryarchaeota,2N9WQ@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
DTH3_k127_9069206_3	926561.KB900623_gene833	8.823e-68	235.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH3_k127_9069206_4	204669.Acid345_1869	1.201e-66	243.0	COG0577@1|root,COG0577@2|Bacteria,3Y36A@57723|Acidobacteria,2JIYT@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DTH3_k127_9069206_6	269799.Gmet_1554	2.817e-24	110.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria,43UZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
DTH3_k127_9069206_9	867845.KI911784_gene1245	2.168e-16	84.0	COG3682@1|root,COG3682@2|Bacteria,2GAQU@200795|Chloroflexi,37733@32061|Chloroflexia	32061|Chloroflexia	K	PFAM Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
DTH3_k127_9069206_10	697281.Mahau_0671	2.471e-05	55.0	COG4219@1|root,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,249NV@186801|Clostridia,42IB4@68295|Thermoanaerobacterales	186801|Clostridia	KT	BlaR1 peptidase M56	-	-	-	ko:K02172	ko01501,map01501	M00627	-	-	ko00000,ko00001,ko00002,ko01002,ko01504	-	-	-	DUF4309,NAGPA,Peptidase_M56,Transpeptidase
DTH3_k127_9069206_0	370438.PTH_0247	4.764e-141	454.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,260EI@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH3_k127_9069206_1	1229909.NSED_01215	8.648e-118	396.0	COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
DTH3_k127_9069206_8	240015.ACP_1678	2.481e-18	93.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria,2JJAP@204432|Acidobacteriia	204432|Acidobacteriia	CO	Glutathione peroxidase	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
DTH3_k127_9069206_2	945713.IALB_0863	3.707e-105	362.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	hao	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Multi-haem_cyto
DTH3_k127_9069206_7	456442.Mboo_2231	1.198e-21	100.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_9069206_5	1449126.JQKL01000002_gene1595	2e-60	213.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DTH3_k127_9075466_2	1128398.Curi_c20040	1.12e-127	418.0	COG3199@1|root,COG3199@2|Bacteria,1UAMM@1239|Firmicutes,249JW@186801|Clostridia,268BY@186813|unclassified Clostridiales	186801|Clostridia	S	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
DTH3_k127_9075466_0	865861.AZSU01000011_gene714	6.263e-205	649.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,36FTT@31979|Clostridiaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
DTH3_k127_9075466_1	865861.AZSU01000003_gene2200	1.962e-179	573.0	COG0403@1|root,COG0403@2|Bacteria,1TTB1@1239|Firmicutes,25D30@186801|Clostridia,36G4S@31979|Clostridiaceae	186801|Clostridia	E	Glycine cleavage system P-protein	-	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
DTH3_k127_9106211_0	1209989.TepiRe1_0613	2.599e-116	390.0	COG1152@1|root,COG1614@1|root,COG1152@2|Bacteria,COG1614@2|Bacteria,1TSWZ@1239|Firmicutes,248Y2@186801|Clostridia,42EW2@68295|Thermoanaerobacterales	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase complex beta subunit	cdhC	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
DTH3_k127_9106211_2	70601.3258125	3.452e-41	160.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,242TV@183968|Thermococci	183968|Thermococci	F	thymidylate kinase	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
DTH3_k127_9106211_1	1459636.NTE_01027	7.495e-67	236.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
DTH3_k127_915311_1	1131462.DCF50_p1758	9.917e-159	518.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DTH3_k127_915311_26	304371.MCP_2678	3.845e-33	139.0	arCOG04609@1|root,arCOG04609@2157|Archaea,2XVS1@28890|Euryarchaeota,2N9XU@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
DTH3_k127_915311_25	1343739.PAP_01610	4.618e-35	143.0	COG0170@1|root,arCOG01880@2157|Archaea,2XY6G@28890|Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	-
DTH3_k127_915311_21	880073.Calab_3225	6.651e-41	162.0	COG0170@1|root,COG1836@1|root,COG0170@2|Bacteria,COG1836@2|Bacteria,2NPNT@2323|unclassified Bacteria	2|Bacteria	I	Integral membrane protein DUF92	-	GO:0005575,GO:0016020	2.7.1.182,2.7.7.41	ko:K00981,ko:K18678	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799,R10659	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF92
DTH3_k127_915311_10	1379698.RBG1_1C00001G1876	1.003e-83	289.0	COG0301@1|root,COG0301@2|Bacteria,2NP8U@2323|unclassified Bacteria	2|Bacteria	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI,tRNA_Me_trans
DTH3_k127_915311_27	1365176.N186_09310	1.223e-20	93.0	COG1872@1|root,arCOG04058@2157|Archaea	2157|Archaea	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
DTH3_k127_915311_0	237368.SCABRO_00111	1.152e-275	864.0	COG1331@1|root,COG1331@2|Bacteria,2IX0N@203682|Planctomycetes	203682|Planctomycetes	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
DTH3_k127_915311_28	1449126.JQKL01000006_gene737	1.82e-20	103.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,26BAW@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
DTH3_k127_915311_6	1156937.MFUM_310051	1.019e-110	368.0	COG1064@1|root,COG1064@2|Bacteria,46VKT@74201|Verrucomicrobia,37H8I@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DTH3_k127_915311_13	868131.MSWAN_0032	6.856e-69	247.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,23PAX@183925|Methanobacteria	183925|Methanobacteria	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
DTH3_k127_915311_5	926550.CLDAP_20810	1.339e-127	417.0	COG0585@1|root,COG0585@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
DTH3_k127_915311_20	767817.Desgi_3267	7.796e-48	174.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,2503A@186801|Clostridia,267CF@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21,Fer4_6
DTH3_k127_915311_14	479434.Sthe_1763	8.578e-68	239.0	COG1024@1|root,COG1024@2|Bacteria,2G6BP@200795|Chloroflexi,27XR0@189775|Thermomicrobia	189775|Thermomicrobia	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
DTH3_k127_915311_9	1123288.SOV_1c09030	6.269e-86	294.0	COG1237@1|root,COG1237@2|Bacteria,1VDQ3@1239|Firmicutes	1239|Firmicutes	S	Beta-lactamase superfamily domain	dhpS	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DTH3_k127_915311_24	579137.Metvu_0459	3.265e-35	142.0	COG0705@1|root,arCOG01770@2157|Archaea,2Y895@28890|Euryarchaeota,23RKY@183939|Methanococci	183939|Methanococci	E	PFAM Rhomboid family protein	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid
DTH3_k127_915311_17	1121422.AUMW01000010_gene1062	2.304e-59	212.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,261T9@186807|Peptococcaceae	186801|Clostridia	S	PFAM Appr-1-p processing	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
DTH3_k127_915311_22	880073.Calab_2491	2.04e-39	161.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DTH3_k127_915311_4	1459636.NTE_01695	4.568e-134	436.0	COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota	651137|Thaumarchaeota	S	small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
DTH3_k127_915311_29	1122921.KB898194_gene841	2.171e-18	89.0	COG1917@1|root,COG1917@2|Bacteria,1V7FN@1239|Firmicutes,4IPSM@91061|Bacilli,26XMU@186822|Paenibacillaceae	91061|Bacilli	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DTH3_k127_915311_16	755731.Clo1100_2670	3.839e-60	213.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,36FKV@31979|Clostridiaceae	186801|Clostridia	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DTH3_k127_915311_12	485918.Cpin_5807	2.527e-69	239.0	COG0847@1|root,COG0847@2|Bacteria,4NJMP@976|Bacteroidetes,1IX24@117747|Sphingobacteriia	976|Bacteroidetes	L	Exonuclease RNase T and DNA polymerase III	-	-	-	-	-	-	-	-	-	-	-	-	DUF5051
DTH3_k127_915311_19	877455.Metbo_1675	2.425e-50	188.0	arCOG01151@1|root,arCOG01151@2157|Archaea	2157|Archaea	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
DTH3_k127_915311_8	456442.Mboo_1155	3.636e-95	322.0	arCOG06074@1|root,arCOG06074@2157|Archaea,2XXIH@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_915311_2	1220534.B655_1154	2.077e-137	460.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
DTH3_k127_915311_18	368407.Memar_1117	7.181e-59	212.0	COG3382@1|root,arCOG04250@2157|Archaea,2Y2KD@28890|Euryarchaeota,2NAIE@224756|Methanomicrobia	224756|Methanomicrobia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
DTH3_k127_915311_3	1209989.TepiRe1_1685	1.66e-135	449.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,42ER0@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
DTH3_k127_915311_11	477974.Daud_1317	1.339e-69	253.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,261KK@186807|Peptococcaceae	186801|Clostridia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
DTH3_k127_915311_23	1121468.AUBR01000054_gene1450	8.299e-38	153.0	COG0109@1|root,COG0109@2|Bacteria,1TPS1@1239|Firmicutes,249CW@186801|Clostridia,42HNV@68295|Thermoanaerobacterales	186801|Clostridia	O	UbiA prenyltransferase family	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
DTH3_k127_915311_15	192952.MM_1844	1.004e-67	246.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2N92Q@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
DTH3_k127_915311_31	765911.Thivi_2699	0.0004725	51.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria,1WW5S@135613|Chromatiales	135613|Chromatiales	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_915311_7	429009.Adeg_1787	1.931e-104	356.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,42FVY@68295|Thermoanaerobacterales	186801|Clostridia	C	hydrogenase large subunit	-	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
DTH3_k127_9162691_2	1121091.AUMP01000005_gene1651	2.917e-49	191.0	COG5002@1|root,COG5002@2|Bacteria,1VUBP@1239|Firmicutes,4HUPW@91061|Bacilli	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,MASE3,MHYT,PAS,PAS_3,PAS_4,PAS_9
DTH3_k127_9162691_1	309801.trd_A0012	1.129e-69	244.0	COG1028@1|root,COG1028@2|Bacteria,2G6SC@200795|Chloroflexi,27YY5@189775|Thermomicrobia	189775|Thermomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DTH3_k127_9162691_0	1449126.JQKL01000014_gene3030	8.442e-173	561.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH3_k127_9162691_3	399550.Smar_1242	1.372e-31	126.0	COG1042@1|root,arCOG01338@2157|Archaea,2XQ9M@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
DTH3_k127_9168979_6	1123371.ATXH01000002_gene380	8.775e-05	46.0	COG2414@1|root,COG2414@2|Bacteria,2GI9E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
DTH3_k127_9168979_3	521011.Mpal_1987	3.399e-36	147.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_9168979_5	1197130.BAFM01000024_gene2976	2.572e-07	61.0	COG0705@1|root,arCOG01768@2157|Archaea,2XTJH@28890|Euryarchaeota,23SS3@183963|Halobacteria	183963|Halobacteria	E	nucleic acid binding protein containing the AN1-type Zn-finger	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
DTH3_k127_9168979_1	1054217.TALC_00320	5.289e-103	346.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,241NP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
DTH3_k127_9168979_4	69014.TK1411	6.66e-10	66.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,2448C@183968|Thermococci	183968|Thermococci	L	UPF0292 protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
DTH3_k127_9168979_0	342949.PNA2_0292	6.463e-112	373.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
DTH3_k127_9168979_2	368408.Tpen_0393	5.121e-91	308.0	COG0417@1|root,arCOG00328@2157|Archaea,2XPM8@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM DNA polymerase (pol2)	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
DTH3_k127_924845_0	637390.AFOH01000136_gene1793	1.834e-54	197.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,1S2JM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NADPH-dependent F420 reductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
DTH3_k127_924845_1	37919.EP51_14165	1.453e-07	53.0	COG3422@1|root,COG3422@2|Bacteria	2|Bacteria	S	double-strand break repair	-	-	-	ko:K09946	-	-	-	-	ko00000	-	-	-	DUF1508
DTH3_k127_9279280_2	1232437.KL661958_gene2890	1.87e-54	197.0	COG1034@1|root,COG1034@2|Bacteria,1RK80@1224|Proteobacteria,43CTD@68525|delta/epsilon subdivisions,2X80Y@28221|Deltaproteobacteria,2MPQ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_7
DTH3_k127_9279280_0	1232437.KL661958_gene2889	3.459e-265	831.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	bamH	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DTH3_k127_9279280_3	316067.Geob_0233	6.114e-43	164.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42SIE@68525|delta/epsilon subdivisions,2WP8B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
DTH3_k127_9279280_4	1303518.CCALI_02450	6.676e-33	143.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DTH3_k127_9279280_8	1041930.Mtc_1892	0.0006524	42.0	COG0508@1|root,arCOG01706@2157|Archaea,2XTSS@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DTH3_k127_9279280_5	592015.HMPREF1705_01721	1.795e-10	66.0	28XQZ@1|root,2ZJMK@2|Bacteria,3TCGY@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_9279280_6	1536774.H70357_19720	8.313e-10	66.0	COG0346@1|root,COG0346@2|Bacteria,1V235@1239|Firmicutes,4HHQP@91061|Bacilli,26WSR@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
DTH3_k127_9279280_1	251221.35211855	4.526e-93	321.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
DTH3_k127_9279280_7	1121342.AUCO01000010_gene2337	7.194e-09	65.0	COG5650@1|root,COG5650@2|Bacteria,1TQVD@1239|Firmicutes,25CFN@186801|Clostridia,36DSE@31979|Clostridiaceae	186801|Clostridia	S	integral membrane protein	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2
DTH3_k127_9320416_3	1268072.PSAB_13605	3.213e-74	259.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,270SS@186822|Paenibacillaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
DTH3_k127_9320416_8	332101.JIBU02000004_gene85	2.603e-25	115.0	COG1073@1|root,COG1073@2|Bacteria,1V84C@1239|Firmicutes,24MJG@186801|Clostridia,36Q2H@31979|Clostridiaceae	186801|Clostridia	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
DTH3_k127_9320416_0	368408.Tpen_0750	1.01e-203	650.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
DTH3_k127_9320416_6	1123373.ATXI01000024_gene116	1.721e-50	185.0	COG0778@1|root,COG0778@2|Bacteria,2GHHZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DTH3_k127_9320416_2	1041930.Mtc_0381	2.638e-146	473.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
DTH3_k127_9320416_4	192952.MM_0471	7.308e-56	207.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
DTH3_k127_9320416_11	368408.Tpen_0482	3.531e-09	67.0	arCOG03727@1|root,arCOG03727@2157|Archaea	2157|Archaea	-	-	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Mrr_cat,NERD
DTH3_k127_9320416_5	1131266.ARWQ01000015_gene750	8.014e-52	198.0	COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
DTH3_k127_9320416_7	444157.Tneu_0025	7.276e-50	183.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DTH3_k127_9320416_9	374847.Kcr_0527	4.835e-20	101.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DTH3_k127_9320416_10	436308.Nmar_0932	1.013e-16	83.0	COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	-	ko:K03014	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
DTH3_k127_9320416_1	368408.Tpen_0291	1.447e-186	597.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPTW@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
DTH3_k127_9336202_6	693661.Arcve_0630	7.774e-09	56.0	COG3350@1|root,arCOG04507@2157|Archaea,2Y1MF@28890|Euryarchaeota	28890|Euryarchaeota	S	pfam yhs	-	-	-	-	-	-	-	-	-	-	-	-	YHS
DTH3_k127_9336202_3	247490.KSU1_C0456	4.216e-124	410.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
DTH3_k127_9336202_2	1459636.NTE_01678	6.591e-127	417.0	COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
DTH3_k127_9336202_7	1227499.C493_17556	1.31e-05	56.0	COG0697@1|root,arCOG00272@2157|Archaea,2XUQJ@28890|Euryarchaeota,23UUC@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DTH3_k127_9336202_5	742766.HMPREF9455_03265	1.254e-54	203.0	COG0152@1|root,COG0152@2|Bacteria,4NF1Z@976|Bacteroidetes,2FPKZ@200643|Bacteroidia,22WD6@171551|Porphyromonadaceae	976|Bacteroidetes	F	Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
DTH3_k127_9336202_4	391623.TERMP_01070	1.005e-112	374.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,243AA@183968|Thermococci	183968|Thermococci	J	required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
DTH3_k127_9336202_0	521011.Mpal_0225	1.987e-303	953.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
DTH3_k127_9336202_1	1304885.AUEY01000020_gene3515	3.019e-287	900.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
DTH3_k127_9348503_2	671143.DAMO_0386	2.621e-69	240.0	COG1048@1|root,COG1048@2|Bacteria,2NNWW@2323|unclassified Bacteria	2|Bacteria	C	Aconitase C-terminal domain	dmdA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
DTH3_k127_9348503_3	933801.Ahos_0200	9.625e-56	198.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQPI@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
DTH3_k127_9348503_1	431943.CKL_2501	1.453e-74	262.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
DTH3_k127_9348503_0	374847.Kcr_0479	2.489e-90	304.0	COG1691@1|root,arCOG02465@2157|Archaea	2157|Archaea	S	1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
DTH3_k127_9348503_4	368408.Tpen_1212	4.483e-52	191.0	COG5012@1|root,arCOG02028@2157|Archaea,2XRVB@28889|Crenarchaeota	28889|Crenarchaeota	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
DTH3_k127_9348503_5	632292.Calhy_0272	2.928e-49	191.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
DTH3_k127_9364268_1	868131.MSWAN_1930	3.713e-49	186.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota	28890|Euryarchaeota	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0200	CdhD
DTH3_k127_9364268_0	456442.Mboo_1369	5.961e-95	327.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
DTH3_k127_9367396_11	456442.Mboo_0955	3.261e-16	79.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUJG@28890|Euryarchaeota,2N9IV@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DTH3_k127_9367396_6	1408422.JHYF01000012_gene3081	1.088e-33	135.0	COG1522@1|root,COG1522@2|Bacteria,1V6TH@1239|Firmicutes,24JH9@186801|Clostridia,36JUP@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
DTH3_k127_9367396_10	349161.Dred_2158	5.979e-26	122.0	COG1522@1|root,COG1522@2|Bacteria,1V6TK@1239|Firmicutes,24KE6@186801|Clostridia,2627S@186807|Peptococcaceae	186801|Clostridia	K	SMART Transcription regulator, AsnC-type	nirD	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
DTH3_k127_9367396_7	386456.JQKN01000002_gene2388	3.5e-33	144.0	COG1587@1|root,arCOG02048@2157|Archaea,2XTA1@28890|Euryarchaeota,23NZX@183925|Methanobacteria	183925|Methanobacteria	H	synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
DTH3_k127_9367396_3	643648.Slip_1426	4.644e-80	274.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,42JPK@68298|Syntrophomonadaceae	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
DTH3_k127_9367396_2	1459636.NTE_01012	1.734e-82	284.0	COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
DTH3_k127_9367396_0	565033.GACE_0110	3.979e-142	462.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,245Z9@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DTH3_k127_9367396_1	429009.Adeg_1257	6.442e-126	411.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
DTH3_k127_9367396_4	1220534.B655_0419	1.302e-77	275.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,23NUA@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
DTH3_k127_9367396_9	868131.MSWAN_0201	1.176e-27	120.0	COG1648@1|root,arCOG01044@2157|Archaea,2XWMY@28890|Euryarchaeota,23P2N@183925|Methanobacteria	183925|Methanobacteria	H	synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7
DTH3_k127_9367396_8	374847.Kcr_0770	5.462e-30	127.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	HTH_AsnC-type
DTH3_k127_9367396_13	591019.Shell_0193	0.0001596	53.0	arCOG04155@1|root,arCOG04155@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_9367396_5	529709.PYCH_03610	2.395e-58	210.0	COG0639@1|root,arCOG01143@2157|Archaea,2XUDG@28890|Euryarchaeota,2435N@183968|Thermococci	183968|Thermococci	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
DTH3_k127_9367396_12	1459636.NTE_01027	8.125e-05	51.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
DTH3_k127_9380689_3	255470.cbdbA1365	4.691e-06	59.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
DTH3_k127_9380689_2	660470.Theba_0226	8.112e-08	64.0	COG1404@1|root,COG1520@1|root,COG4412@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG4412@2|Bacteria,2GED2@200918|Thermotogae	200918|Thermotogae	O	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_9380689_0	192952.MM_1737	4.363e-95	323.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2N9ER@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DTH3_k127_9380689_1	694429.Pyrfu_1064	5.322e-48	189.0	COG0683@1|root,arCOG01020@2157|Archaea,2XQM1@28889|Crenarchaeota	28889|Crenarchaeota	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DTH3_k127_9394264_4	1131266.ARWQ01000008_gene328	4.205e-14	77.0	COG0328@1|root,arCOG02942@2157|Archaea,41SWJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	RNase H	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
DTH3_k127_9394264_1	195522.BD01_0213	1.796e-73	254.0	COG1042@1|root,arCOG01338@2157|Archaea,2XXCA@28890|Euryarchaeota,2435P@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
DTH3_k127_9394264_2	1459636.NTE_02213	7.894e-55	201.0	COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
DTH3_k127_9394264_3	572478.Vdis_1330	5.184e-51	191.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
DTH3_k127_9394264_5	1392491.JIAE01000001_gene1155	8.419e-05	48.0	COG1996@1|root,COG1996@2|Bacteria,1UI9I@1239|Firmicutes,24IQ4@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_9394264_0	694429.Pyrfu_1762	5.194e-197	631.0	COG1245@1|root,arCOG00187@2157|Archaea,2XPQF@28889|Crenarchaeota	28889|Crenarchaeota	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,Fer4_6,RLI
DTH3_k127_952838_8	1160707.AJIK01000016_gene2745	7.174e-36	140.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,26F58@186818|Planococcaceae	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
DTH3_k127_952838_7	330214.NIDE2201	1.493e-40	158.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DTH3_k127_952838_12	247490.KSU1_D0453	7.705e-09	61.0	2EGSE@1|root,33AII@2|Bacteria,2J3TB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DTH3_k127_952838_0	368408.Tpen_0130	3.16e-309	981.0	COG0060@1|root,arCOG00807@2157|Archaea,2XPWM@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
DTH3_k127_952838_1	3641.EOY19667	6.017e-77	289.0	COG1287@1|root,KOG2292@2759|Eukaryota,37M0F@33090|Viridiplantae,3G8TE@35493|Streptophyta	35493|Streptophyta	O	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit	STT3B	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0071944,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
DTH3_k127_952838_5	224325.AF_0525	1.228e-49	188.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
DTH3_k127_952838_11	436308.Nmar_0076	4.284e-11	65.0	COG2260@1|root,arCOG00906@2157|Archaea,41SUI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
DTH3_k127_952838_3	272844.PAB0568	3.074e-55	202.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,243FV@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
DTH3_k127_952838_10	573063.Metin_0775	5.799e-15	78.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,23R97@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein S27E	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
DTH3_k127_952838_9	1459636.NTE_03120	8.018e-28	115.0	COG1631@1|root,arCOG04109@2157|Archaea,41SQZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
DTH3_k127_952838_13	1459636.NTE_00425	0.000241	51.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
DTH3_k127_952838_2	368408.Tpen_0622	1.037e-67	246.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
DTH3_k127_952838_4	192952.MM_1396	1.143e-51	196.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
DTH3_k127_952838_6	633148.Tagg_0042	1.09e-46	177.0	COG0592@1|root,arCOG00488@2157|Archaea,2XQCF@28889|Crenarchaeota	28889|Crenarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
DTH3_k127_979611_7	926550.CLDAP_01850	8.665e-42	163.0	COG1668@1|root,COG1668@2|Bacteria,2G76A@200795|Chloroflexi	200795|Chloroflexi	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
DTH3_k127_979611_3	1144275.COCOR_06077	1.878e-68	243.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42S2J@68525|delta/epsilon subdivisions,2X7BN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DTH3_k127_979611_0	1443122.Z958_00375	1.442e-110	363.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,36DM3@31979|Clostridiaceae	186801|Clostridia	C	Fe-S type, tartrate fumarate subfamily, alpha	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
DTH3_k127_979611_4	1118054.CAGW01000056_gene2099	1.596e-67	237.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,4IQVA@91061|Bacilli	91061|Bacilli	C	COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
DTH3_k127_979611_2	1347392.CCEZ01000043_gene137	1.323e-78	273.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,36EJD@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DTH3_k127_979611_8	1121422.AUMW01000008_gene502	3e-33	133.0	COG2050@1|root,COG2050@2|Bacteria,1VFHF@1239|Firmicutes,24QNY@186801|Clostridia,262QC@186807|Peptococcaceae	186801|Clostridia	Q	PFAM thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
DTH3_k127_979611_6	797209.ZOD2009_07809	2.433e-48	179.0	COG2041@1|root,arCOG00264@2157|Archaea,2XU2G@28890|Euryarchaeota,23SCW@183963|Halobacteria	183963|Halobacteria	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
DTH3_k127_979611_9	398511.BpOF4_07260	5.231e-13	78.0	COG0454@1|root,COG0456@2|Bacteria,1U521@1239|Firmicutes,4HBEJ@91061|Bacilli,1ZCHR@1386|Bacillus	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	ykwB	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DTH3_k127_979611_1	1459636.NTE_01332	2.794e-102	345.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DTH3_k127_979611_5	1047013.AQSP01000128_gene457	2.408e-56	205.0	COG2848@1|root,COG2848@2|Bacteria,2NPVH@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
DTH3_k127_990576_6	1151117.AJLF01000001_gene1091	2.184e-23	102.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
DTH3_k127_990576_9	933801.Ahos_0792	7.223e-09	59.0	COG1383@1|root,arCOG01885@2157|Archaea,2XRGM@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
DTH3_k127_990576_7	1183377.Py04_1713	1.533e-14	76.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
DTH3_k127_990576_4	399550.Smar_0791	9.904e-33	136.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
DTH3_k127_990576_5	1459636.NTE_03306	2.43e-25	111.0	COG1958@1|root,arCOG00999@2157|Archaea	2157|Archaea	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
DTH3_k127_990576_2	877455.Metbo_0211	8.123e-38	151.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,23P1D@183925|Methanobacteria	183925|Methanobacteria	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
DTH3_k127_990576_8	1154757.Q5C_00210	1.824e-10	64.0	COG1942@1|root,COG1942@2|Bacteria,1VKD5@1239|Firmicutes,4HRBS@91061|Bacilli,4AY5W@81850|Leuconostocaceae	91061|Bacilli	G	protein, 4-oxalocrotonate tautomerase homolog	dmpI	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0044237	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
DTH3_k127_990576_0	694429.Pyrfu_0098	1.22e-119	404.0	COG0343@1|root,arCOG00989@2157|Archaea,2XPSY@28889|Crenarchaeota	28889|Crenarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
DTH3_k127_990576_3	694429.Pyrfu_0097	9.708e-34	139.0	COG1938@1|root,arCOG00347@2157|Archaea,2XPV9@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
DTH3_k127_990576_1	1459636.NTE_03316	2.093e-115	386.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
## 1674 queries scanned
## Total time (seconds): 41.28770446777344
## Rate: 40.54 q/s