## Sun Mar 16 09:31:52 2025
## emapper-2.1.9
## /home/zhangkaihang/.conda/envs/eggnog-mapper/bin/emapper.py -i /home/zhangkaihang/metadata_analysis/metawrap/paddysoil/4paddy/bin4gtdbtk/DYD2_bin.10.fa -m mmseqs --itype genome -o DYD2_bin.10 --output_dir /home/zhangkaihang/metadata_analysis/eggnog-mapper/paddysoil/4paddy/DYD2_bin.10 --cpu 8
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
DYD2_k127_104275_7	562983.HMPREF0433_00276	8.651e-07	59.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,4HATN@91061|Bacilli,3WEPR@539002|Bacillales incertae sedis	91061|Bacilli	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
DYD2_k127_104275_6	43354.JOIJ01000021_gene662	2.806e-23	108.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4DZ4U@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DYD2_k127_104275_8	502558.EGYY_14170	6.619e-06	57.0	COG1426@1|root,COG1426@2|Bacteria,2HUY0@201174|Actinobacteria,4CVYX@84998|Coriobacteriia	84998|Coriobacteriia	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
DYD2_k127_104275_1	1246474.ANBE01000051_gene1144	2.927e-180	592.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4EGSR@85012|Streptosporangiales	201174|Actinobacteria	D	Ftsk_gamma	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
DYD2_k127_104275_4	1172185.KB911514_gene4296	5.364e-81	300.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4FX3X@85025|Nocardiaceae	201174|Actinobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
DYD2_k127_104275_0	1313172.YM304_25950	4.034e-186	595.0	COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria,4CMUK@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
DYD2_k127_104275_5	1089544.KB912942_gene3413	3.543e-77	271.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4DYC5@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
DYD2_k127_104275_2	1394178.AWOO02000010_gene4176	2.424e-116	388.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4EHPV@85012|Streptosporangiales	201174|Actinobacteria	S	Insulinase (Peptidase family M16)	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DYD2_k127_104275_3	1121877.JQKF01000004_gene1119	4.8e-115	381.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CMSF@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,S1
DYD2_k127_1042964_1	1184609.KILIM_067_00250	1.169e-22	108.0	COG2385@1|root,COG2385@2|Bacteria,2HFHM@201174|Actinobacteria,4F69I@85018|Dermatophilaceae	201174|Actinobacteria	D	Stage II sporulation protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIID
DYD2_k127_1042964_0	1380347.JNII01000005_gene3925	0.0	1401.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4ES42@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
DYD2_k127_1057555_1	1382359.JIAL01000001_gene1008	7.633e-67	235.0	COG1691@1|root,COG1691@2|Bacteria,3Y3BX@57723|Acidobacteria,2JI0G@204432|Acidobacteriia	204432|Acidobacteriia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
DYD2_k127_1057555_9	351607.Acel_2106	6.204e-17	93.0	COG1196@1|root,COG1196@2|Bacteria,2IMXX@201174|Actinobacteria,4ET89@85013|Frankiales	201174|Actinobacteria	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
DYD2_k127_1057555_2	1237500.ANBA01000027_gene1995	1.648e-66	237.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4EGK0@85012|Streptosporangiales	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
DYD2_k127_1057555_0	1146883.BLASA_0258	1.088e-126	426.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4EREN@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
DYD2_k127_1057555_4	1123366.TH3_17749	1.791e-50	188.0	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2JSWH@204441|Rhodospirillales	204441|Rhodospirillales	M	COG1247 Sortase and related acyltransferases	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
DYD2_k127_1057555_3	1415780.JPOG01000001_gene1140	4.58e-52	194.0	2C75R@1|root,2ZCK5@2|Bacteria,1NMP7@1224|Proteobacteria,1SHMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
DYD2_k127_1057555_6	675635.Psed_5849	5.871e-30	129.0	COG0644@1|root,COG0644@2|Bacteria,2HZIE@201174|Actinobacteria,4EBY4@85010|Pseudonocardiales	201174|Actinobacteria	C	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1057555_8	1206731.BAGB01000047_gene5503	7.958e-20	101.0	COG2267@1|root,COG2267@2|Bacteria,2HVC1@201174|Actinobacteria,4FX8V@85025|Nocardiaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
DYD2_k127_1057555_7	1380354.JIAN01000005_gene2600	6.303e-27	120.0	COG1401@1|root,COG1401@2|Bacteria,2IAXR@201174|Actinobacteria	201174|Actinobacteria	V	restriction endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1057555_5	864069.MicloDRAFT_00010740	4.809e-37	146.0	COG0454@1|root,COG0456@2|Bacteria,1QUB5@1224|Proteobacteria	1224|Proteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
DYD2_k127_1057555_10	5465.ENH87257	0.0009063	51.0	COG1404@1|root,KOG4266@2759|Eukaryota,38HI5@33154|Opisthokonta,3NWUG@4751|Fungi,3QQXB@4890|Ascomycota,211HI@147550|Sordariomycetes,1EV98@1028384|Glomerellales	4751|Fungi	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8,fn3_5
DYD2_k127_108077_6	1122603.ATVI01000009_gene2618	5.009e-10	69.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X3FB@135614|Xanthomonadales	135614|Xanthomonadales	NU	twitching motility protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
DYD2_k127_108077_0	1122182.KB903818_gene1992	4.333e-181	578.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4DB2D@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
DYD2_k127_108077_3	909613.UO65_3405	5.862e-99	343.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4DYYV@85010|Pseudonocardiales	201174|Actinobacteria	F	PFAM AIR synthase related protein	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DYD2_k127_108077_5	1121380.JNIW01000015_gene2586	2.085e-18	89.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
DYD2_k127_108077_2	103733.JNYO01000004_gene7571	1.03e-102	353.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4DXDX@85010|Pseudonocardiales	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DYD2_k127_108077_1	58123.JOFJ01000022_gene3613	1.644e-121	405.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4EFPJ@85012|Streptosporangiales	201174|Actinobacteria	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
DYD2_k127_108077_4	83332.Rv2497c	7.548e-40	152.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,234HF@1762|Mycobacteriaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
DYD2_k127_1143968_0	525904.Tter_2639	3.486e-53	194.0	COG5637@1|root,COG5637@2|Bacteria,2NRUC@2323|unclassified Bacteria	2|Bacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
DYD2_k127_1143968_1	222534.KB893705_gene5860	2.214e-25	118.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4EXBT@85013|Frankiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DYD2_k127_1168036_2	98439.AJLL01000098_gene1986	3.927e-62	219.0	COG0388@1|root,COG0388@2|Bacteria,1G2G2@1117|Cyanobacteria,1JKGB@1189|Stigonemataceae	1117|Cyanobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DYD2_k127_1168036_4	1230476.C207_00117	3.08e-38	154.0	COG1024@1|root,COG1024@2|Bacteria,1R6CV@1224|Proteobacteria,2TSB3@28211|Alphaproteobacteria,3JZ57@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
DYD2_k127_1168036_10	745411.B3C1_16104	7.64e-05	51.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,1S5Y3@1236|Gammaproteobacteria,1J6RX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG2030 Acyl dehydratase	phaJ	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
DYD2_k127_1168036_1	479432.Sros_6623	5.057e-112	376.0	COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,4EKB6@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_1168036_0	1038859.AXAU01000058_gene4132	6.209e-116	388.0	COG0251@1|root,COG0251@2|Bacteria,1NDYI@1224|Proteobacteria,2VD5Y@28211|Alphaproteobacteria,3K0TA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
DYD2_k127_1168036_6	35754.JNYJ01000043_gene4416	2.993e-34	140.0	2CBRB@1|root,33SV2@2|Bacteria,2IJ64@201174|Actinobacteria,4DK0U@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1168036_7	406818.XBJ1_2777	2.914e-27	115.0	2DX5J@1|root,343FP@2|Bacteria,1P0N1@1224|Proteobacteria,1SRUZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1168036_9	196162.Noca_4098	3.846e-17	90.0	2AE7Y@1|root,3141Y@2|Bacteria,2HDMT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1168036_3	1451261.AS96_07885	1.388e-41	162.0	COG5398@1|root,COG5398@2|Bacteria,2H90I@201174|Actinobacteria,4FNVY@85023|Microbacteriaceae	201174|Actinobacteria	P	Heme oxygenase	hmuO	-	1.14.15.20	ko:K21480	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R11579	RC01270	ko00000,ko00001,ko01000	-	-	-	Heme_oxygenase
DYD2_k127_1168036_5	68570.DC74_6853	1.885e-34	145.0	COG0596@1|root,COG0596@2|Bacteria,2IDI0@201174|Actinobacteria	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
DYD2_k127_1168036_8	1122214.AQWH01000004_gene972	8.653e-19	89.0	COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,2UFFG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DYD2_k127_1170748_4	1283299.AUKG01000001_gene2458	8.127e-07	56.0	28TIQ@1|root,2ZFSJ@2|Bacteria,2I6IR@201174|Actinobacteria,4CSHG@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1170748_0	649638.Trad_0358	4.208e-103	345.0	COG0479@1|root,COG0479@2|Bacteria,1WIEW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
DYD2_k127_1170748_1	203124.Tery_0369	1.136e-59	214.0	COG5424@1|root,COG5424@2|Bacteria,1G23M@1117|Cyanobacteria,1H8T4@1150|Oscillatoriales	1117|Cyanobacteria	H	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
DYD2_k127_1170748_2	1463909.KL585973_gene86	1.605e-25	114.0	COG1487@1|root,COG1487@2|Bacteria,2ISD3@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_1170748_3	469383.Cwoe_0460	3.289e-12	72.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
DYD2_k127_1205346_2	1379270.AUXF01000005_gene665	2.547e-71	259.0	COG0564@1|root,COG0564@2|Bacteria,1ZSXN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DYD2_k127_1205346_3	266940.Krad_3189	1.161e-27	123.0	COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria	201174|Actinobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
DYD2_k127_1205346_4	2002.JOEQ01000006_gene1300	1.565e-20	103.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4EJJN@85012|Streptosporangiales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
DYD2_k127_1205346_0	525904.Tter_0977	9.126e-197	628.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
DYD2_k127_1205346_1	525904.Tter_0977	6.649e-89	310.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
DYD2_k127_1205346_5	1131269.AQVV01000009_gene1137	7.044e-08	56.0	COG0012@1|root,COG0012@2|Bacteria	2|Bacteria	J	GTP binding	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
DYD2_k127_1269835_2	1155714.KB891988_gene1593	5.648e-16	79.0	COG1598@1|root,COG1598@2|Bacteria,2GSPM@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1269835_1	562970.Btus_2959	8.586e-18	86.0	COG1724@1|root,COG1724@2|Bacteria,1VIGY@1239|Firmicutes	1239|Firmicutes	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
DYD2_k127_1269835_0	518766.Rmar_1140	1.003e-53	202.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_1295371_4	1122239.AULS01000003_gene2671	1.929e-44	168.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria,4FNKR@85023|Microbacteriaceae	201174|Actinobacteria	NOU	Type IV leader peptidase family	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
DYD2_k127_1295371_9	1385521.N803_10435	1.201e-11	69.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4FHPI@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DYD2_k127_1295371_2	351607.Acel_1313	7.492e-73	258.0	COG4972@1|root,COG4972@2|Bacteria,2IBNF@201174|Actinobacteria,4ET6Y@85013|Frankiales	201174|Actinobacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
DYD2_k127_1295371_8	1121428.DESHY_60054___1	4.473e-12	75.0	COG3166@1|root,COG3166@2|Bacteria,1VEGW@1239|Firmicutes,24R7P@186801|Clostridia,2632U@186807|Peptococcaceae	186801|Clostridia	NU	PFAM Fimbrial assembly family protein	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
DYD2_k127_1295371_10	351607.Acel_1311	2.523e-07	62.0	COG3167@1|root,COG3167@2|Bacteria,2HUWV@201174|Actinobacteria,4EX01@85013|Frankiales	201174|Actinobacteria	NU	carbon utilization	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1295371_0	1121946.AUAX01000008_gene7204	8.981e-137	447.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4DAFR@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
DYD2_k127_1295371_6	1286171.EAL2_c15020	9.29e-29	123.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,25WIY@186806|Eubacteriaceae	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
DYD2_k127_1295371_3	1489678.RDMS_07550	3.838e-72	256.0	COG0337@1|root,COG0337@2|Bacteria,1WIQK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
DYD2_k127_1295371_5	765420.OSCT_2298	8.207e-31	126.0	COG0757@1|root,COG0757@2|Bacteria,2G6N1@200795|Chloroflexi,3775Y@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
DYD2_k127_1295371_1	591158.SSMG_02242	1.202e-85	299.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the peptidase M24B family	pepQ	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
DYD2_k127_1295371_7	1292373.H640_04183	1.135e-22	106.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4DPJT@85009|Propionibacteriales	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
DYD2_k127_1318804_15	298654.FraEuI1c_6924	0.0007191	49.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria,4EWI4@85013|Frankiales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
DYD2_k127_1318804_6	1907.SGLAU_31405	5.367e-43	168.0	COG2267@1|root,COG2267@2|Bacteria,2I39T@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	bpoC	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
DYD2_k127_1318804_10	935866.JAER01000005_gene75	3.709e-23	111.0	COG1670@1|root,COG1670@2|Bacteria,2ISSE@201174|Actinobacteria,4DWJT@85009|Propionibacteriales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DYD2_k127_1318804_16	1996.JOFO01000003_gene6151	0.0009609	51.0	COG0454@1|root,COG0456@2|Bacteria,2IFM6@201174|Actinobacteria,4EJGH@85012|Streptosporangiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Condensation
DYD2_k127_1318804_13	349741.Amuc_0362	5.027e-09	64.0	2ERYI@1|root,33JHP@2|Bacteria,46WPE@74201|Verrucomicrobia,2IUEZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1318804_1	106370.Francci3_3881	4.69e-124	406.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4ES7R@85013|Frankiales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
DYD2_k127_1318804_9	867903.ThesuDRAFT_01152	3.116e-25	108.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,24NEC@186801|Clostridia,3WDRA@538999|Clostridiales incertae sedis	186801|Clostridia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DYD2_k127_1318804_7	1295642.H839_09313	3.129e-37	149.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,4HJDZ@91061|Bacilli,1WFPG@129337|Geobacillus	91061|Bacilli	S	SdpI/YhfL protein family	yvaZ	GO:0008150,GO:0009636,GO:0042221,GO:0050896	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
DYD2_k127_1318804_0	525909.Afer_0305	3.948e-154	496.0	COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria,4CMRQ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_1318804_4	526225.Gobs_4251	2.007e-50	186.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria,4ESNE@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DYD2_k127_1318804_5	1236976.JCM16418_3729	2.139e-46	179.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H9V0@91061|Bacilli,26SQY@186822|Paenibacillaceae	91061|Bacilli	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
DYD2_k127_1318804_11	1122927.KB895413_gene1972	1.223e-21	104.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H9V0@91061|Bacilli,26SQY@186822|Paenibacillaceae	91061|Bacilli	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
DYD2_k127_1318804_3	278957.ABEA03000021_gene1720	4.197e-53	198.0	COG0566@1|root,COG0566@2|Bacteria,46TF9@74201|Verrucomicrobia,3K7VA@414999|Opitutae	414999|Opitutae	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
DYD2_k127_1318804_12	1123023.JIAI01000002_gene5888	9.104e-17	91.0	COG2755@1|root,COG2755@2|Bacteria,2GMVS@201174|Actinobacteria,4E0HC@85010|Pseudonocardiales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DYD2_k127_1318804_2	1463856.JOHY01000008_gene894	1.65e-55	197.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria	201174|Actinobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
DYD2_k127_1320519_0	1123024.AUII01000010_gene715	1.966e-09	70.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4E5U9@85010|Pseudonocardiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
DYD2_k127_1320519_1	933115.GPDM_04129	0.0003366	51.0	COG3227@1|root,COG3227@2|Bacteria,1TSGU@1239|Firmicutes,4HC7W@91061|Bacilli	91061|Bacilli	E	Peptidase M36	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PepSY,Peptidase_M36
DYD2_k127_1325215_1	1379270.AUXF01000001_gene2403	5.959e-51	190.0	COG0596@1|root,COG0596@2|Bacteria,1ZU90@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
DYD2_k127_1325215_0	356851.JOAN01000013_gene5808	7.301e-74	258.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4D9RZ@85008|Micromonosporales	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DYD2_k127_1326770_9	1128421.JAGA01000002_gene230	2.095e-21	94.0	COG1129@1|root,COG1129@2|Bacteria,2NS56@2323|unclassified Bacteria	2|Bacteria	G	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,ECF-ribofla_trS
DYD2_k127_1326770_3	479434.Sthe_0926	2.833e-90	309.0	COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi,27XTB@189775|Thermomicrobia	189775|Thermomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
DYD2_k127_1326770_5	316274.Haur_2902	9.731e-53	197.0	COG1122@1|root,COG1122@2|Bacteria,2G6FK@200795|Chloroflexi,37779@32061|Chloroflexia	32061|Chloroflexia	P	ECF transporter, substrate-specific component	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF_trnsprt
DYD2_k127_1326770_7	525904.Tter_1833	1.378e-28	117.0	COG2151@1|root,COG2151@2|Bacteria,2NPUI@2323|unclassified Bacteria	2|Bacteria	S	Pfam:DUF59	yitW	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
DYD2_k127_1326770_0	1206101.AZXC01000002_gene6154	8.375e-225	704.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria	201174|Actinobacteria	O	assembly protein sufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
DYD2_k127_1326770_4	525904.Tter_1697	9.485e-60	222.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
DYD2_k127_1326770_8	208439.AJAP_05080	2.261e-27	113.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4E5WK@85010|Pseudonocardiales	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
DYD2_k127_1326770_2	1379698.RBG1_1C00001G0735	3.46e-92	310.0	COG0396@1|root,COG0396@2|Bacteria,2NNYE@2323|unclassified Bacteria	2|Bacteria	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
DYD2_k127_1326770_1	485913.Krac_8822	1.077e-141	471.0	COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
DYD2_k127_1326770_6	263358.VAB18032_22370	1.824e-36	145.0	COG4447@1|root,COG4447@2|Bacteria,2I4PF@201174|Actinobacteria,4DC47@85008|Micromonosporales	201174|Actinobacteria	E	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
DYD2_k127_1364083_3	1528106.JRJE01000032_gene3206	8.634e-07	59.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JRKY@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
DYD2_k127_1364083_2	1120934.KB894403_gene393	1.466e-13	81.0	COG2346@1|root,COG2346@2|Bacteria,2I95U@201174|Actinobacteria,4ECXX@85010|Pseudonocardiales	201174|Actinobacteria	S	COG2346, Truncated hemoglobins	-	-	-	-	-	-	-	-	-	-	-	-	Bac_globin,Fer4_19,zf-CDGSH
DYD2_k127_1364083_0	1121405.dsmv_3342	3.387e-23	106.0	COG1487@1|root,COG1487@2|Bacteria,1NAWB@1224|Proteobacteria,42ZRS@68525|delta/epsilon subdivisions,2WV1Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
DYD2_k127_1364083_4	330214.NIDE0652	5.947e-06	51.0	2EC1X@1|root,33GB5@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	-
DYD2_k127_1364083_1	211165.AJLN01000120_gene768	6.54e-17	86.0	COG2402@1|root,COG2402@2|Bacteria,1GKCJ@1117|Cyanobacteria,1JMED@1189|Stigonemataceae	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_1365486_2	357808.RoseRS_4114	2.434e-17	92.0	COG3356@1|root,COG3356@2|Bacteria,2G7ZP@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1365486_0	1192034.CAP_4201	1.043e-59	229.0	COG3356@1|root,COG3356@2|Bacteria,1Q66U@1224|Proteobacteria,4358C@68525|delta/epsilon subdivisions,2WZJF@28221|Deltaproteobacteria,2Z29I@29|Myxococcales	28221|Deltaproteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
DYD2_k127_1365486_1	937777.Deipe_2571	2.319e-25	109.0	COG1286@1|root,COG2340@1|root,COG1286@2|Bacteria,COG2340@2|Bacteria,1WK37@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
DYD2_k127_1422484_6	1382306.JNIM01000001_gene274	1.722e-11	64.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G6X3@200795|Chloroflexi	200795|Chloroflexi	H	NAD synthase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
DYD2_k127_1422484_1	1267533.KB906740_gene199	5.689e-85	291.0	COG0413@1|root,COG0413@2|Bacteria,3Y3GX@57723|Acidobacteria,2JI6Y@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
DYD2_k127_1422484_4	1121877.JQKF01000001_gene1342	3.497e-33	140.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,4CNRB@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
DYD2_k127_1422484_5	864702.OsccyDRAFT_3217	1.584e-21	109.0	COG0454@1|root,COG0456@2|Bacteria,1G407@1117|Cyanobacteria,1H9GX@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_1422484_2	42256.RradSPS_2320	1.514e-68	241.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4CTQB@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
DYD2_k127_1422484_3	469383.Cwoe_0961	9.884e-59	216.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CRTX@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
DYD2_k127_1422484_0	469383.Cwoe_0960	2.222e-134	438.0	COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4CPSQ@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_1470091_3	298654.FraEuI1c_7163	1.284e-13	74.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4ESST@85013|Frankiales	201174|Actinobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
DYD2_k127_1470091_2	525909.Afer_0043	5.189e-20	91.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4CN8W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
DYD2_k127_1470091_0	1299327.I546_5036	7.323e-43	162.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,232AP@1762|Mycobacteriaceae	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
DYD2_k127_1470091_1	545697.HMPREF0216_00119	2.083e-24	105.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,36JK5@31979|Clostridiaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
DYD2_k127_1470091_4	1202768.JROF01000031_gene2095	3.81e-08	61.0	COG3794@1|root,arCOG02917@2157|Archaea	2157|Archaea	C	blue (type 1) copper	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
DYD2_k127_1472240_0	1120936.KB907219_gene3239	5.985e-165	542.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4EH6A@85012|Streptosporangiales	201174|Actinobacteria	L	DSHCT	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
DYD2_k127_1472240_4	402881.Plav_1670	1.984e-35	147.0	COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,2U7IG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
DYD2_k127_1472240_2	1120936.KB907209_gene1507	9.078e-94	321.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,4EFU2@85012|Streptosporangiales	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
DYD2_k127_1472240_1	235985.BBPN01000020_gene6477	4.041e-138	449.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,2NHRD@228398|Streptacidiphilus	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_1472240_3	1288484.APCS01000018_gene1983	1.036e-37	155.0	COG0419@1|root,COG0419@2|Bacteria,1WJ38@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	ATPase involved in DNA repair	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
DYD2_k127_1490724_2	1206741.BAFX01000084_gene6270	1.265e-44	179.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1490724_3	390989.JOEG01000012_gene3296	4.197e-11	75.0	COG1862@1|root,COG1862@2|Bacteria,2IQSP@201174|Actinobacteria,4DFMC@85008|Micromonosporales	201174|Actinobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
DYD2_k127_1490724_0	1713.JOFV01000007_gene2990	2.911e-84	298.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4F1XH@85016|Cellulomonadaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
DYD2_k127_1490724_1	351607.Acel_1340	4.428e-76	271.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4ERCU@85013|Frankiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
DYD2_k127_1501674_0	391625.PPSIR1_19974	1.882e-25	112.0	COG3070@1|root,COG3070@2|Bacteria,1QEQQ@1224|Proteobacteria,4318J@68525|delta/epsilon subdivisions,2WWGX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
DYD2_k127_1501674_2	1187851.A33M_0456	8.167e-16	81.0	COG2329@1|root,COG2329@2|Bacteria,1NDM8@1224|Proteobacteria,2UG48@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ydhR
DYD2_k127_1504696_2	263358.VAB18032_20665	1.091e-31	127.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4DA1E@85008|Micromonosporales	201174|Actinobacteria	S	MmgE PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
DYD2_k127_1504696_0	512565.AMIS_57430	2.883e-183	584.0	COG0044@1|root,COG0044@2|Bacteria,2GKEC@201174|Actinobacteria,4DAQD@85008|Micromonosporales	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.2,3.5.2.3,3.5.2.5	ko:K01464,ko:K01465,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00051,M00546	R01993,R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
DYD2_k127_1504696_1	2002.JOEQ01000005_gene3805	3.669e-81	278.0	COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,4EP9K@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
DYD2_k127_151957_0	1289387.AUKW01000023_gene2970	7.098e-80	284.0	COG0613@1|root,COG0613@2|Bacteria,2IDTP@201174|Actinobacteria	201174|Actinobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
DYD2_k127_151957_1	1120949.KB903294_gene4655	1.2e-24	115.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	MEDS,STAS,STAS_2
DYD2_k127_1558804_3	1121939.L861_19245	5.106e-43	161.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1SZ0M@1236|Gammaproteobacteria,1XKZK@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
DYD2_k127_1558804_0	983917.RGE_08940	2.623e-60	213.0	COG1670@1|root,COG1670@2|Bacteria,1RKKE@1224|Proteobacteria,2VWB1@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DYD2_k127_1558804_2	246197.MXAN_1194	1.54e-52	198.0	COG2162@1|root,COG2162@2|Bacteria,1RDF3@1224|Proteobacteria,42UY1@68525|delta/epsilon subdivisions,2WSDJ@28221|Deltaproteobacteria,2YVZI@29|Myxococcales	28221|Deltaproteobacteria	Q	Belongs to the arylamine N-acetyltransferase family	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
DYD2_k127_1558804_1	861299.J421_0701	1.003e-52	191.0	COG0563@1|root,COG0563@2|Bacteria	2|Bacteria	F	adenylate kinase activity	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_18,ADK,ADK_lid
DYD2_k127_1562415_0	926550.CLDAP_09440	8.005e-151	486.0	COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DYD2_k127_1562415_1	502025.Hoch_0876	7.461e-13	79.0	COG3591@1|root,COG3591@2|Bacteria,1NP6U@1224|Proteobacteria,437JH@68525|delta/epsilon subdivisions,2X2TH@28221|Deltaproteobacteria,2YXUB@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
DYD2_k127_1594667_3	1150399.AQYK01000001_gene273	1.138e-48	184.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4FMCU@85023|Microbacteriaceae	201174|Actinobacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
DYD2_k127_1594667_0	593907.Celgi_0241	1.057e-74	270.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4F0PR@85016|Cellulomonadaceae	201174|Actinobacteria	O	ResB-like family	resB	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
DYD2_k127_1594667_1	326424.FRAAL1004	1.366e-71	254.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4ESE9@85013|Frankiales	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
DYD2_k127_1594667_2	67315.JOBD01000039_gene4836	3.847e-49	186.0	COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_1599006_1	479432.Sros_6513	6.896e-108	367.0	COG2133@1|root,COG2133@2|Bacteria,2I9ZW@201174|Actinobacteria,4EQ0V@85012|Streptosporangiales	201174|Actinobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,Laminin_G_3
DYD2_k127_1599006_0	1192868.CAIU01000036_gene4343	5.308e-113	376.0	COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2TT7U@28211|Alphaproteobacteria,43H78@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
DYD2_k127_1599006_2	867845.KI911784_gene1835	1.035e-36	143.0	COG3877@1|root,COG3877@2|Bacteria,2G734@200795|Chloroflexi,375SX@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
DYD2_k127_1599006_3	926554.KI912637_gene3323	7.478e-15	80.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
DYD2_k127_159971_2	1206741.BAFX01000084_gene6270	5.236e-41	168.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_159971_1	1206101.AZXC01000021_gene2175	8.245e-86	304.0	COG2866@1|root,COG2866@2|Bacteria,2GN49@201174|Actinobacteria	201174|Actinobacteria	E	carboxypeptidase	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14
DYD2_k127_159971_0	1048339.KB913029_gene1452	1.151e-89	299.0	COG0566@1|root,COG0566@2|Bacteria,2GM1A@201174|Actinobacteria,4ERY0@85013|Frankiales	201174|Actinobacteria	J	SpoU rRNA Methylase family	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
DYD2_k127_1628505_2	1292020.H483_0106970	6.081e-31	129.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
DYD2_k127_1628505_1	1047013.AQSP01000139_gene2393	8.865e-64	224.0	COG1704@1|root,COG1704@2|Bacteria,2NPIW@2323|unclassified Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DYD2_k127_1628505_0	1313172.YM304_19800	1.176e-87	300.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CNA7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
DYD2_k127_1628505_3	1168065.DOK_17735	1.228e-14	82.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,DUF2048,Peptidase_S9
DYD2_k127_1648032_0	1123320.KB889574_gene5695	1.399e-140	452.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
DYD2_k127_1648032_3	649747.HMPREF0083_00499	8.424e-15	83.0	2C5TN@1|root,30GQP@2|Bacteria,1V4GH@1239|Firmicutes,4HJ3A@91061|Bacilli,27365@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1648032_6	477641.MODMU_2087	1.224e-06	55.0	COG0766@1|root,COG1396@1|root,COG0766@2|Bacteria,COG1396@2|Bacteria,2GJPW@201174|Actinobacteria,4ERJ6@85013|Frankiales	201174|Actinobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
DYD2_k127_1648032_1	485913.Krac_7969	5.305e-140	457.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	patA	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K05830,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00031,M00763,M00845	R01155,R02283,R04475,R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DYD2_k127_1648032_5	526227.Mesil_2780	2.129e-09	64.0	COG3794@1|root,COG3794@2|Bacteria,1WKPV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
DYD2_k127_1648032_4	1071085.KK033115_gene2340	1.42e-13	84.0	COG3794@1|root,arCOG02921@2157|Archaea,2XZ0D@28890|Euryarchaeota,23WZS@183963|Halobacteria	183963|Halobacteria	C	COG3794 Plastocyanin	hcp4	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,TAT_signal
DYD2_k127_1648032_2	1121354.AQUV01000001_gene1322	4.151e-72	248.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,22KCY@1653|Corynebacteriaceae	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DYD2_k127_1651606_3	1122201.AUAZ01000001_gene2223	9.687e-26	107.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,1RQIK@1236|Gammaproteobacteria,46C5D@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	mhpB	-	-	-	-	-	-	-	-	-	-	-	LigB
DYD2_k127_1651606_2	1906.SFRA_04115	2.391e-28	122.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	GO:0000988,GO:0000990,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
DYD2_k127_1651606_0	266117.Rxyl_2540	1.11e-193	625.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CPJ8@84995|Rubrobacteria	84995|Rubrobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
DYD2_k127_1651606_1	1242864.D187_005109	3.594e-69	250.0	COG0477@1|root,COG2814@2|Bacteria,1QRUM@1224|Proteobacteria,42MFJ@68525|delta/epsilon subdivisions,2X2AQ@28221|Deltaproteobacteria,2Z25Q@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
DYD2_k127_1651606_4	1499968.TCA2_4165	0.000633	51.0	COG1575@1|root,COG1575@2|Bacteria,1U4PK@1239|Firmicutes,4I6NH@91061|Bacilli,26TX8@186822|Paenibacillaceae	91061|Bacilli	H	Ubiquinone biosynthesis protein UbiA	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
DYD2_k127_1669290_3	656024.FsymDg_1229	1.667e-07	63.0	2DWSS@1|root,341Q8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1669290_0	106370.Francci3_3165	2.839e-56	215.0	COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria,4ESHT@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
DYD2_k127_1669290_2	1157490.EL26_21855	1.495e-36	153.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4HA3R@91061|Bacilli,278GC@186823|Alicyclobacillaceae	91061|Bacilli	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	nagD	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
DYD2_k127_1669290_4	1116369.KB890024_gene3076	1.098e-06	61.0	COG0394@1|root,COG1246@1|root,COG0394@2|Bacteria,COG1246@2|Bacteria,1MWYQ@1224|Proteobacteria,2TU1U@28211|Alphaproteobacteria,43NQK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Low molecular weight phosphatase family	arsC1	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DYD2_k127_1669290_1	1121033.AUCF01000009_gene1133	3.464e-51	190.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2JRGA@204441|Rhodospirillales	204441|Rhodospirillales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
DYD2_k127_1706011_5	511051.CSE_10910	4.892e-38	154.0	COG2316@1|root,COG2316@2|Bacteria	2|Bacteria	J	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
DYD2_k127_1706011_2	357808.RoseRS_3857	1.718e-153	512.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi,37597@32061|Chloroflexia	32061|Chloroflexia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
DYD2_k127_1706011_4	1214101.BN159_2577	6.428e-55	200.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria	201174|Actinobacteria	P	PFAM TrkA-N domain protein	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DYD2_k127_1706011_3	685727.REQ_20380	3.51e-63	228.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4FX3G@85025|Nocardiaceae	201174|Actinobacteria	P	TrkA-C domain	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
DYD2_k127_1706011_7	298655.KI912266_gene5274	1.384e-10	66.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria,4ETC1@85013|Frankiales	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1706011_0	469371.Tbis_0223	1.791e-254	806.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4DY9J@85010|Pseudonocardiales	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
DYD2_k127_1706011_6	935866.JAER01000014_gene1736	1.032e-31	137.0	COG1316@1|root,COG1316@2|Bacteria,2IAW9@201174|Actinobacteria,4DTHV@85009|Propionibacteriales	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
DYD2_k127_1706011_1	58123.JOFJ01000002_gene2447	7.258e-236	752.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4EG7V@85012|Streptosporangiales	201174|Actinobacteria	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
DYD2_k127_1712738_4	1144275.COCOR_06368	2.127e-20	98.0	COG4552@1|root,COG4552@2|Bacteria,1NBTH@1224|Proteobacteria,42W5G@68525|delta/epsilon subdivisions,2WXK2@28221|Deltaproteobacteria,2YW0Z@29|Myxococcales	28221|Deltaproteobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
DYD2_k127_1712738_0	1382359.JIAL01000001_gene577	1.09e-200	641.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
DYD2_k127_1712738_1	344747.PM8797T_26625	4.868e-90	312.0	COG1611@1|root,COG1611@2|Bacteria,2IXIR@203682|Planctomycetes	203682|Planctomycetes	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
DYD2_k127_1712738_2	1160718.SU9_24457	2.397e-30	124.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DYD2_k127_1712738_3	1283299.AUKG01000002_gene3739	1.685e-21	98.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,2HQTG@201174|Actinobacteria,4CSIS@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_172716_1	1185876.BN8_01058	1.253e-05	57.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
DYD2_k127_172716_0	1343740.M271_47790	4.331e-60	216.0	COG1063@1|root,COG1063@2|Bacteria,2GNFX@201174|Actinobacteria	201174|Actinobacteria	E	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
DYD2_k127_1750851_0	929556.Solca_0753	2.076e-115	377.0	COG0500@1|root,COG2226@2|Bacteria,4NFRD@976|Bacteroidetes,1IVKT@117747|Sphingobacteriia	976|Bacteroidetes	Q	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DYD2_k127_1750851_2	443218.AS9A_2587	1.365e-58	218.0	COG0824@1|root,COG0824@2|Bacteria,2IMQK@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1750851_9	1380391.JIAS01000015_gene215	6.042e-12	76.0	COG0515@1|root,COG0515@2|Bacteria,1QZ10@1224|Proteobacteria	1224|Proteobacteria	KLT	Domain of unknown function (DUF4328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4328
DYD2_k127_1750851_6	243231.GSU0630	1.128e-31	141.0	COG0500@1|root,COG2226@2|Bacteria,1N73D@1224|Proteobacteria,42XDU@68525|delta/epsilon subdivisions,2WRMM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DYD2_k127_1750851_1	318424.EU78_24315	4.585e-68	247.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,23559@1762|Mycobacteriaceae	201174|Actinobacteria	M	UDP-glucose 4-epimerase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
DYD2_k127_1750851_5	278963.ATWD01000001_gene3503	1.395e-35	151.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_1750851_3	269799.Gmet_2888	1.038e-56	220.0	COG2244@1|root,COG2244@2|Bacteria,1RHFX@1224|Proteobacteria,42TXE@68525|delta/epsilon subdivisions,2WSBE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3
DYD2_k127_1750851_8	1385935.N836_33000	2.383e-25	117.0	COG0500@1|root,COG2226@2|Bacteria,1GQNU@1117|Cyanobacteria,1HHXR@1150|Oscillatoriales	1117|Cyanobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
DYD2_k127_1750851_4	886293.Sinac_2960	7.651e-36	148.0	COG0463@1|root,COG0463@2|Bacteria,2J550@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_1750851_7	269799.Gmet_2886	4.301e-28	124.0	COG2227@1|root,COG2227@2|Bacteria,1QY93@1224|Proteobacteria,42VQY@68525|delta/epsilon subdivisions,2WRC2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
DYD2_k127_1750851_10	931276.Cspa_c45510	0.0001373	49.0	COG0110@1|root,COG0110@2|Bacteria,1TPKX@1239|Firmicutes,249X2@186801|Clostridia,36DHA@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (Isoleucine patch superfamily)	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
DYD2_k127_1770894_0	561175.KB894096_gene834	2.405e-193	619.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria,4EH14@85012|Streptosporangiales	201174|Actinobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
DYD2_k127_1770894_3	246194.CHY_1567	8.011e-48	178.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,42I9V@68295|Thermoanaerobacterales	186801|Clostridia	L	Methylpurine-DNA glycosylase (MPG)	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
DYD2_k127_1770894_2	1229780.BN381_290106	1.724e-116	403.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,3UW69@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
DYD2_k127_1770894_1	357808.RoseRS_2069	1.839e-129	426.0	COG0162@1|root,COG0162@2|Bacteria,2G64J@200795|Chloroflexi,375RR@32061|Chloroflexia	32061|Chloroflexia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
DYD2_k127_1770894_4	1304865.JAGF01000001_gene3980	1.2e-10	70.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
DYD2_k127_1794468_2	479433.Caci_6551	5.266e-19	93.0	COG0454@1|root,COG0456@2|Bacteria,2ISWJ@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_1794468_0	414684.RC1_0226	2.305e-230	724.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,2JZIB@204441|Rhodospirillales	204441|Rhodospirillales	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
DYD2_k127_1794468_1	861208.AGROH133_15140	2.8e-59	215.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2V825@28211|Alphaproteobacteria,4BG91@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
DYD2_k127_1794468_3	110319.CF8_0498	7.811e-08	64.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CBM_6,Cytochrom_C,LVIVD,Laminin_G_3,NPCBM,PA,PKD,RicinB_lectin_2,Ricin_B_lectin
DYD2_k127_1802583_3	1146883.BLASA_2953	3.855e-75	264.0	COG0745@1|root,COG0745@2|Bacteria,2GJRR@201174|Actinobacteria,4ESGE@85013|Frankiales	201174|Actinobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DYD2_k127_1802583_1	110319.CF8_0231	3.942e-117	396.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4DNTA@85009|Propionibacteriales	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1,Thioredoxin_4
DYD2_k127_1802583_6	743719.PaelaDRAFT_4449	9.425e-28	130.0	COG1409@1|root,COG1621@1|root,COG4632@1|root,COG5492@1|root,COG1409@2|Bacteria,COG1621@2|Bacteria,COG4632@2|Bacteria,COG5492@2|Bacteria,1UI3P@1239|Firmicutes,4HJMZ@91061|Bacilli,27713@186822|Paenibacillaceae	91061|Bacilli	GN	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Metallophos,NAGPA,Pur_ac_phosph_N,SLH
DYD2_k127_1802583_4	512565.AMIS_60630	1.343e-51	192.0	COG2120@1|root,COG2120@2|Bacteria,2IDT2@201174|Actinobacteria,4DGNW@85008|Micromonosporales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
DYD2_k127_1802583_2	68219.JNXI01000002_gene3959	2.039e-75	261.0	2EYIJ@1|root,33RSC@2|Bacteria,2IPA3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1802583_0	1415780.JPOG01000001_gene3335	1.261e-195	627.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria,1X7J4@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
DYD2_k127_1802583_7	1179773.BN6_44050	1.543e-18	97.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4E10P@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
DYD2_k127_18093_2	1120936.KB907208_gene1214	8.377e-11	73.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4EJ41@85012|Streptosporangiales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
DYD2_k127_18093_0	1121926.AXWO01000003_gene648	9.788e-49	186.0	COG0559@1|root,COG0559@2|Bacteria,2GNXY@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DYD2_k127_18093_1	1110502.TMO_3065	4.245e-41	172.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TT26@28211|Alphaproteobacteria,2JPYZ@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DYD2_k127_1831106_8	936455.KI421499_gene1549	7.506e-10	65.0	COG0454@1|root,COG0456@2|Bacteria,1R6DW@1224|Proteobacteria,2U3QR@28211|Alphaproteobacteria,3JRBT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DYD2_k127_1831106_2	452863.Achl_2921	3.712e-59	213.0	2EQ8K@1|root,33HUV@2|Bacteria,2H13Z@201174|Actinobacteria	201174|Actinobacteria	S	Camelysin metallo-endopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M73
DYD2_k127_1831106_4	1380356.JNIK01000013_gene4097	2.601e-29	125.0	COG0681@1|root,COG0681@2|Bacteria,2IIF5@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DYD2_k127_1831106_6	1280390.CBQR020000036_gene820	7.43e-14	78.0	COG4409@1|root,COG5297@1|root,COG4409@2|Bacteria,COG5297@2|Bacteria,1V1T2@1239|Firmicutes,4HUDU@91061|Bacilli,26S1Z@186822|Paenibacillaceae	1239|Firmicutes	G	Belongs to the glycosyl hydrolase family 6	-	GO:0005575,GO:0005576	3.2.1.176,3.2.1.4	ko:K01179,ko:K20829	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH48,GH5,GH9	-	CBM_3,CBM_X2,Dockerin_1,Glyco_hydro_48,Glyco_hydro_9
DYD2_k127_1831106_0	1463821.JOGR01000011_gene2108	1.096e-79	273.0	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4EZKW@85014|Glycomycetales	201174|Actinobacteria	S	KR domain	sdh	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.381	ko:K16066	ko00240,ko00260,ko01100,map00240,map00260,map01100	-	R09289,R10851,R10852	RC00087,RC00525,RC03288	ko00000,ko00001,ko01000	-	-	-	adh_short
DYD2_k127_1831106_3	5911.EAS04801	2.004e-41	160.0	COG0235@1|root,COG1791@1|root,KOG2107@2759|Eukaryota,KOG2631@2759|Eukaryota,3ZDSW@5878|Ciliophora	5878|Ciliophora	G	Class II Aldolase and Adducin N-terminal domain	-	-	1.13.11.53,1.13.11.54	ko:K08967	ko00270,ko01100,map00270,map01100	M00034	R07363,R07364	RC01866,RC02018,RC02118	ko00000,ko00001,ko00002,ko01000	-	-	-	ARD,Aldolase_II
DYD2_k127_1831106_9	1286093.C266_07131	9.812e-07	60.0	COG1917@1|root,COG1917@2|Bacteria,1QWV7@1224|Proteobacteria,2WG74@28216|Betaproteobacteria,1KIAR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ARD/ARD' family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DYD2_k127_1831106_5	743525.TSC_c03990	3.64e-22	101.0	COG1569@1|root,COG1569@2|Bacteria,1WJX8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
DYD2_k127_1831106_7	472759.Nhal_0622	7.4e-11	65.0	2EK4T@1|root,33DV8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1831106_1	756067.MicvaDRAFT_3420	5.931e-70	259.0	COG0823@1|root,COG2931@1|root,COG0823@2|Bacteria,COG2931@2|Bacteria,1G554@1117|Cyanobacteria,1HF7I@1150|Oscillatoriales	1117|Cyanobacteria	QU	PFAM Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PD40
DYD2_k127_1837351_0	1121423.JONT01000026_gene903	3.244e-155	517.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,260CD@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
DYD2_k127_1837351_1	868595.Desca_0165	2.009e-79	275.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,260RP@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
DYD2_k127_1837351_2	1303518.CCALI_00718	3.096e-33	131.0	COG0157@1|root,COG0157@2|Bacteria	2|Bacteria	H	quinolinate catabolic process	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1988,iHN637.CLJU_RS12010,iLJ478.TM1645	QRPTase_C,QRPTase_N
DYD2_k127_1864001_0	525909.Afer_0395	2.615e-237	746.0	COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4CMTM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DYD2_k127_1864001_1	1123023.JIAI01000015_gene3279	5.733e-208	652.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4DZDG@85010|Pseudonocardiales	201174|Actinobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DYD2_k127_1864001_7	351607.Acel_0305	1.352e-48	175.0	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4ESVR@85013|Frankiales	201174|Actinobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
DYD2_k127_1864001_3	1123322.KB904651_gene466	1.084e-81	278.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
DYD2_k127_1864001_6	1313172.YM304_08260	1.519e-60	220.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4CN29@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
DYD2_k127_1864001_9	710111.FraQA3DRAFT_3871	2.358e-31	126.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4ET1Y@85013|Frankiales	201174|Actinobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
DYD2_k127_1864001_2	1125718.HMPREF1318_1152	3.293e-130	422.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4D3TJ@85005|Actinomycetales	201174|Actinobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
DYD2_k127_1864001_8	446470.Snas_1189	5.345e-37	141.0	COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4EYW7@85014|Glycomycetales	201174|Actinobacteria	J	Ribosomal protein S19	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
DYD2_k127_1864001_10	1221537.B807_472	1.801e-29	123.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,4HIK2@91061|Bacilli,3F6K6@33958|Lactobacillaceae	91061|Bacilli	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
DYD2_k127_1864001_4	1108045.GORHZ_078_00160	6.993e-78	280.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4GB87@85026|Gordoniaceae	201174|Actinobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
DYD2_k127_1864001_5	1348908.KI518578_gene658	3.298e-68	233.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,4HFPN@91061|Bacilli,1ZFMZ@1386|Bacillus	91061|Bacilli	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
DYD2_k127_1864001_11	935948.KE386495_gene1504	2.993e-12	67.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,42H7J@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
DYD2_k127_1911606_0	1499967.BAYZ01000069_gene1888	7.084e-170	545.0	COG0442@1|root,COG0442@2|Bacteria,2NNKF@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
DYD2_k127_1911606_4	749414.SBI_01628	2.324e-100	339.0	COG0668@1|root,COG0668@2|Bacteria,2GZI1@201174|Actinobacteria	201174|Actinobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
DYD2_k127_1911606_1	1064537.AGSO01000009_gene2243	9.485e-125	420.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4FDIV@85020|Dermabacteraceae	201174|Actinobacteria	I	GcpE protein	ispG	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
DYD2_k127_1911606_6	1121926.AXWO01000025_gene3879	2.684e-70	252.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4EXNF@85014|Glycomycetales	201174|Actinobacteria	M	Peptidase family M50	rip1	GO:0008150,GO:0040007	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
DYD2_k127_1911606_3	1122175.ATXU01000001_gene977	2.23e-105	354.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4FK72@85023|Microbacteriaceae	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
DYD2_k127_1911606_9	1095767.CAHD01000227_gene1024	8.069e-36	147.0	COG0575@1|root,COG0575@2|Bacteria,2I7ZA@201174|Actinobacteria,4F10G@85016|Cellulomonadaceae	201174|Actinobacteria	I	PFAM phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
DYD2_k127_1911606_7	351607.Acel_1539	6.191e-61	215.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4ESC9@85013|Frankiales	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
DYD2_k127_1911606_5	1120936.KB907226_gene2851	1.101e-90	305.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4EG3D@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DYD2_k127_1911606_8	935948.KE386494_gene260	2.504e-57	210.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,42EMG@68295|Thermoanaerobacterales	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
DYD2_k127_1911606_2	994479.GL877878_gene414	2.109e-105	350.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4DZ1Y@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
DYD2_k127_1918155_3	477974.Daud_1182	5.831e-63	235.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,260K3@186807|Peptococcaceae	186801|Clostridia	E	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
DYD2_k127_1918155_6	1121877.JQKF01000026_gene2431	6.802e-38	147.0	COG4401@1|root,COG4401@2|Bacteria,2IHWT@201174|Actinobacteria,4CNUX@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Chorismate mutase type I	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
DYD2_k127_1918155_2	2074.JNYD01000001_gene5838	2.241e-70	249.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4DXJJ@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
DYD2_k127_1918155_5	469371.Tbis_1492	1.207e-46	173.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4DZVG@85010|Pseudonocardiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
DYD2_k127_1918155_4	1229780.BN381_290072	8.891e-53	196.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,3UWJ9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
DYD2_k127_1918155_8	1089551.KE386572_gene2663	1.915e-16	87.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2TRIF@28211|Alphaproteobacteria,4BS33@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase M50	MA20_27160	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
DYD2_k127_1918155_7	1463881.KL591011_gene2900	8.015e-19	92.0	2E3JK@1|root,32YHZ@2|Bacteria,2GS0Y@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1918155_0	390989.JOEG01000035_gene1758	1.468e-100	338.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4DAR4@85008|Micromonosporales	201174|Actinobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
DYD2_k127_1918155_9	552811.Dehly_0108	5.29e-15	82.0	COG1734@1|root,COG1734@2|Bacteria,2GAUG@200795|Chloroflexi,34DDM@301297|Dehalococcoidia	301297|Dehalococcoidia	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
DYD2_k127_1918155_1	1123023.JIAI01000030_gene4403	3.707e-82	282.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DYBT@85010|Pseudonocardiales	201174|Actinobacteria	L	Tyrosine recombinase XerD	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
DYD2_k127_1933932_2	1121382.JQKG01000004_gene3992	1.258e-62	230.0	COG4124@1|root,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_26
DYD2_k127_1933932_7	402777.KB235904_gene3871	2.808e-16	87.0	COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H781@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_1933932_9	1089553.Tph_c20790	1.438e-09	69.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1V33I@1239|Firmicutes	1239|Firmicutes	IM	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.7.74,2.7.8.34	ko:K07281,ko:K07291	ko00562,map00562	-	R09669,R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,NTP_transf_3
DYD2_k127_1933932_0	1457393.AZ09_12835	1.556e-93	323.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,2JQBA@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the pyruvate kinase family	ttuE	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
DYD2_k127_1933932_4	2074.JNYD01000012_gene178	7.083e-50	187.0	COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4E191@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the UPF0234 family	trpF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
DYD2_k127_1933932_8	204669.Acid345_1407	1.27e-11	73.0	COG2340@1|root,COG2340@2|Bacteria,3Y4KF@57723|Acidobacteria,2JJCG@204432|Acidobacteriia	204432|Acidobacteriia	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
DYD2_k127_1933932_5	935863.AWZR01000013_gene1503	2.236e-35	146.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
DYD2_k127_1933932_1	1380390.JIAT01000012_gene3217	1.497e-80	272.0	COG3576@1|root,COG3576@2|Bacteria,2GP9M@201174|Actinobacteria,4CSSB@84995|Rubrobacteria	84995|Rubrobacteria	S	Pfam:Pyridox_oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
DYD2_k127_1933932_3	1122603.ATVI01000006_gene83	2.06e-62	228.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	SGL,VCBS
DYD2_k127_1933932_6	1382356.JQMP01000003_gene1535	2.784e-22	109.0	COG1565@1|root,COG1565@2|Bacteria,2G8NS@200795|Chloroflexi,27Y3B@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
DYD2_k127_1935624_0	1380355.JNIJ01000002_gene4170	4.925e-29	128.0	COG0454@1|root,COG0456@2|Bacteria,1RDNX@1224|Proteobacteria,2U70R@28211|Alphaproteobacteria,3JYM0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DYD2_k127_1935624_1	1123024.AUII01000008_gene1831	4.457e-21	106.0	COG2755@1|root,COG2755@2|Bacteria,2GR6W@201174|Actinobacteria,4DZQ1@85010|Pseudonocardiales	201174|Actinobacteria	E	O-octanoyltransferase activity	octT	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008374,GO:0009987,GO:0016020,GO:0016043,GO:0016414,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0040007,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051262,GO:0065003,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DYD2_k127_1936206_3	1446473.JHWH01000009_gene322	4.976e-10	68.0	COG0785@1|root,COG0785@2|Bacteria,1RBAA@1224|Proteobacteria,2U6KU@28211|Alphaproteobacteria,2PWJY@265|Paracoccus	28211|Alphaproteobacteria	O	Cytochrome C biogenesis protein	mauF	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1936206_2	196490.AUEZ01000115_gene1203	5.853e-25	111.0	COG0526@1|root,COG0526@2|Bacteria,1R3WA@1224|Proteobacteria,2U3RM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	methylamine dehydrogenase accessory protein MauD	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_2
DYD2_k127_1936206_1	1144275.COCOR_03695	1.32e-38	165.0	COG3055@1|root,COG3055@2|Bacteria,1QA41@1224|Proteobacteria,43DXI@68525|delta/epsilon subdivisions,2X90U@28221|Deltaproteobacteria,2Z1C1@29|Myxococcales	28221|Deltaproteobacteria	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1936206_0	479432.Sros_8404	6.587e-102	341.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4EFRE@85012|Streptosporangiales	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	mcl1	-	4.1.3.34,5.4.99.63	ko:K01644,ko:K14447	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R09292	RC00067,RC01118,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
DYD2_k127_1936206_4	436308.Nmar_1660	0.0001625	53.0	arCOG08113@1|root,arCOG08113@2157|Archaea	2157|Archaea	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1943810_4	646529.Desaci_3207	4.38e-30	123.0	COG2359@1|root,COG2359@2|Bacteria,1V6G8@1239|Firmicutes,24MXY@186801|Clostridia,26255@186807|Peptococcaceae	186801|Clostridia	S	PFAM Stage V sporulation protein S	spoVS	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
DYD2_k127_1943810_0	861299.J421_3703	2.992e-137	445.0	COG3185@1|root,COG3185@2|Bacteria,1ZT62@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
DYD2_k127_1943810_1	1267535.KB906767_gene335	6.902e-120	397.0	COG3508@1|root,COG3508@2|Bacteria,3Y38R@57723|Acidobacteria	57723|Acidobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
DYD2_k127_1943810_2	1048339.KB913029_gene3302	5.567e-82	282.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4ES7X@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
DYD2_k127_1943810_6	1122138.AQUZ01000025_gene2783	3.637e-11	68.0	COG2172@1|root,COG2172@2|Bacteria,2IFG9@201174|Actinobacteria,4DSGA@85009|Propionibacteriales	201174|Actinobacteria	T	anti-sigma regulatory factor	rsbW	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
DYD2_k127_1943810_5	263358.VAB18032_06335	6.443e-30	123.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4DE05@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
DYD2_k127_1943810_3	1380390.JIAT01000009_gene2233	4.924e-67	255.0	COG0642@1|root,COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,2GKEF@201174|Actinobacteria,4CU1G@84995|Rubrobacteria	84995|Rubrobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,PAS_9,SpoIIE
DYD2_k127_1946327_1	1380347.JNII01000005_gene3745	8.828e-34	148.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_1946327_0	469383.Cwoe_2565	5.397e-282	885.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CR1R@84995|Rubrobacteria	84995|Rubrobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
DYD2_k127_1946327_3	383372.Rcas_4228	1.303e-07	63.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,Response_reg
DYD2_k127_1946327_2	1120949.KB903306_gene7471	5.149e-29	130.0	COG0642@1|root,COG2205@2|Bacteria,2I2XR@201174|Actinobacteria,4DH19@85008|Micromonosporales	201174|Actinobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9
DYD2_k127_1950752_4	316274.Haur_3861	2.065e-26	125.0	2DBZC@1|root,32TYH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_3,RicinB_lectin_2
DYD2_k127_1950752_5	35754.JNYJ01000011_gene777	2.025e-23	117.0	COG4833@1|root,COG4833@2|Bacteria	2|Bacteria	G	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92,Lipase_GDSL_2,RicinB_lectin_2,Ricin_B_lectin
DYD2_k127_1950752_1	1341151.ASZU01000008_gene1395	1.771e-60	224.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,27B9F@186824|Thermoactinomycetaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DYD2_k127_1950752_2	420324.KI912069_gene6385	1.166e-40	163.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
DYD2_k127_1950752_0	68223.JNZY01000052_gene358	5.281e-91	313.0	COG0477@1|root,COG2814@2|Bacteria,2ID9K@201174|Actinobacteria	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_1950752_3	1123319.AUBE01000015_gene5674	6.15e-35	151.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_1991071_6	497964.CfE428DRAFT_5098	6.758e-05	55.0	COG1075@1|root,COG1404@1|root,COG3055@1|root,COG3391@1|root,COG1075@2|Bacteria,COG1404@2|Bacteria,COG3055@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	1.1.3.6,3.2.1.4	ko:K01179,ko:K03333,ko:K12287	ko00500,ko00984,ko01100,ko01120,map00500,map00984,map01100,map01120	-	R01459,R06200,R11307,R11308	RC00146	ko00000,ko00001,ko01000,ko02044	-	GH5,GH9	-	Kelch_1,Laminin_G_3,Malectin
DYD2_k127_1991071_2	1289387.AUKW01000003_gene2702	4.904e-50	196.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1991071_0	455632.SGR_2373	8.631e-127	418.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4185V@629295|Streptomyces griseus group	201174|Actinobacteria	D	Iron-sulfur cluster assembly protein	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
DYD2_k127_1991071_3	1386969.AWTB01000117_gene166	3.931e-14	79.0	COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2GM2U@201174|Actinobacteria,4GDB4@85026|Gordoniaceae	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain (presumed)	bmrU	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
DYD2_k127_1991071_5	1123325.JHUV01000008_gene787	2.358e-07	59.0	COG1826@1|root,COG1826@2|Bacteria,2G4BU@200783|Aquificae	200783|Aquificae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	-	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
DYD2_k127_1991071_1	1172188.KB911829_gene4433	5.417e-58	218.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4FEHF@85021|Intrasporangiaceae	201174|Actinobacteria	O	PDZ domain (Also known as DHR or GLGF)	degP	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
DYD2_k127_1991071_7	1229780.BN381_210111	8.109e-05	53.0	2C8AG@1|root,33SQR@2|Bacteria,2H3BF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1991071_4	1501391.LG35_06060	1.994e-13	72.0	COG5496@1|root,COG5496@2|Bacteria,4NR7G@976|Bacteroidetes,2FUCR@200643|Bacteroidia,22VHP@171550|Rikenellaceae	976|Bacteroidetes	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_200697_0	471852.Tcur_0242	2.153e-221	706.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4EH4E@85012|Streptosporangiales	201174|Actinobacteria	C	4Fe-4S dicluster domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
DYD2_k127_2013040_3	1121403.AUCV01000030_gene2788	2.032e-12	75.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
DYD2_k127_2013040_1	1382306.JNIM01000001_gene3511	2.476e-74	266.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
DYD2_k127_2013040_0	928724.SacglDRAFT_01393	2.926e-269	841.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4DX6U@85010|Pseudonocardiales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
DYD2_k127_2013040_2	662755.CRES_0654	1.051e-18	93.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,22NVQ@1653|Corynebacteriaceae	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
DYD2_k127_2026183_2	436229.JOEH01000002_gene3412	4.13e-05	53.0	COG1225@1|root,COG1225@2|Bacteria,2GQGH@201174|Actinobacteria	201174|Actinobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	MauE
DYD2_k127_2026183_0	43759.JNWK01000010_gene4709	1.845e-20	106.0	COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,2GKNI@201174|Actinobacteria	201174|Actinobacteria	Q	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF5122,HemolysinCabind
DYD2_k127_2026183_1	4529.ORUFI01G07430.1	2.552e-07	62.0	arCOG05967@1|root,2QSXK@2759|Eukaryota,37JS6@33090|Viridiplantae,3GBKD@35493|Streptophyta,3M4U3@4447|Liliopsida,3I5SY@38820|Poales	35493|Streptophyta	S	Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A	-	-	-	-	-	-	-	-	-	-	-	-	PNGaseA
DYD2_k127_2060898_2	479432.Sros_6625	6.109e-39	153.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4EGPF@85012|Streptosporangiales	201174|Actinobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
DYD2_k127_2060898_0	512565.AMIS_57110	3.821e-182	578.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DHP2@85008|Micromonosporales	201174|Actinobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
DYD2_k127_2060898_1	479432.Sros_6336	1.513e-74	254.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4EK0J@85012|Streptosporangiales	201174|Actinobacteria	I	MaoC like domain	-	-	4.2.1.56	ko:K18290	ko00660,map00660	-	R02491	RC00730	ko00000,ko00001,ko01000	-	-	-	MaoC_dehydratas
DYD2_k127_2060898_3	1151117.AJLF01000001_gene985	1.004e-13	77.0	COG1487@1|root,arCOG02225@2157|Archaea,2Y6G6@28890|Euryarchaeota,244G3@183968|Thermococci	183968|Thermococci	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_2062770_2	32049.SYNPCC7002_A1130	0.0001924	46.0	COG1364@1|root,COG1364@2|Bacteria,1G1H7@1117|Cyanobacteria,1GZ07@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.argJ	ArgJ
DYD2_k127_2062770_1	1121430.JMLG01000002_gene1072	7.151e-91	312.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,2602H@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DYD2_k127_2062770_0	264732.Moth_1750	3.881e-168	552.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,42F4K@68295|Thermoanaerobacterales	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
DYD2_k127_206901_2	1121272.KB903261_gene6326	1.132e-05	51.0	COG2172@1|root,COG2172@2|Bacteria,2GQJD@201174|Actinobacteria,4DM9Q@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
DYD2_k127_206901_0	246194.CHY_1492	8.048e-148	478.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,42ERE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_206901_1	1121472.AQWN01000003_gene1420	2.407e-75	262.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,260JZ@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
DYD2_k127_2083750_4	987059.RBXJA2T_16217	5.017e-120	402.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,1KJ0W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
DYD2_k127_2083750_3	1380390.JIAT01000009_gene1316	1.423e-120	408.0	COG0028@1|root,COG0028@2|Bacteria,2GKQM@201174|Actinobacteria,4CR18@84995|Rubrobacteria	84995|Rubrobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DYD2_k127_2083750_12	443144.GM21_2451	6.666e-06	57.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,fn3
DYD2_k127_2083750_1	1380347.JNII01000008_gene4263	1.056e-169	546.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4EREP@85013|Frankiales	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
DYD2_k127_2083750_8	1283283.ATXA01000006_gene1810	1.33e-60	219.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4ERE5@85013|Frankiales	201174|Actinobacteria	O	Clp domain protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DYD2_k127_2083750_6	1380370.JIBA01000013_gene1157	1.325e-83	284.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4FEIG@85021|Intrasporangiaceae	201174|Actinobacteria	I	1-acyl-sn-glycerol-3-phosphate acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
DYD2_k127_2083750_7	68570.DC74_2608	4.195e-67	239.0	COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria	201174|Actinobacteria	S	Esterase	yvaK	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
DYD2_k127_2083750_5	477641.MODMU_3515	5.901e-94	316.0	COG1915@1|root,COG1915@2|Bacteria,2GMEZ@201174|Actinobacteria,4EUTP@85013|Frankiales	201174|Actinobacteria	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
DYD2_k127_2083750_10	390989.JOEG01000021_gene2644	2.681e-47	171.0	COG1915@1|root,COG1915@2|Bacteria,2GMEZ@201174|Actinobacteria	201174|Actinobacteria	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
DYD2_k127_2083750_9	1158762.KB898042_gene932	1.925e-60	219.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria,1X09I@135613|Chromatiales	135613|Chromatiales	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DYD2_k127_2083750_0	391623.TERMP_00992	2.422e-171	548.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
DYD2_k127_2083750_11	156978.CIMIT_11380	5.569e-12	68.0	COG2608@1|root,COG2608@2|Bacteria,2I1G4@201174|Actinobacteria,22P6Z@1653|Corynebacteriaceae	201174|Actinobacteria	P	COG2608 Copper chaperone	-	-	-	-	-	-	-	-	-	-	-	-	HMA
DYD2_k127_2083750_2	1150599.MPHLEI_26332	3.23e-158	512.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,232VV@1762|Mycobacteriaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DYD2_k127_2142834_7	945713.IALB_0011	3.887e-22	102.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DYD2_k127_2142834_0	525904.Tter_0881	4.543e-288	898.0	COG0365@1|root,COG0365@2|Bacteria,2NNSQ@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
DYD2_k127_2142834_5	1122622.ATWJ01000013_gene189	2.536e-45	174.0	2B9NF@1|root,3230S@2|Bacteria,2IGF5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	-
DYD2_k127_2142834_6	1385520.N802_06270	9.738e-28	124.0	COG4711@1|root,COG4711@2|Bacteria,2HBCQ@201174|Actinobacteria	201174|Actinobacteria	S	Putative integral membrane protein (DUF2391)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2391
DYD2_k127_2142834_3	469383.Cwoe_2070	1.115e-89	306.0	28INB@1|root,2Z8NQ@2|Bacteria,2GM2K@201174|Actinobacteria	201174|Actinobacteria	S	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
DYD2_k127_2142834_1	869210.Marky_1475	7.772e-122	404.0	COG2265@1|root,COG2265@2|Bacteria,1WI5R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
DYD2_k127_2142834_4	1120936.KB907216_gene3712	3.602e-56	207.0	COG5637@1|root,COG5637@2|Bacteria,2GMK7@201174|Actinobacteria,4EIPW@85012|Streptosporangiales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
DYD2_k127_2142834_8	1265310.CCBD010000069_gene466	2.031e-18	91.0	2BG9C@1|root,32A6J@2|Bacteria,2GPNJ@201174|Actinobacteria,23AWE@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2142834_2	977880.RALTA_B2106	1.011e-109	364.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,2VI3B@28216|Betaproteobacteria,1K0AG@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA Topoisomerase	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
DYD2_k127_2147034_5	450380.JPSY01000001_gene51	2.043e-18	87.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4FMFN@85023|Microbacteriaceae	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
DYD2_k127_2147034_1	266117.Rxyl_0836	8.063e-110	367.0	COG0075@1|root,COG0075@2|Bacteria,2GM5F@201174|Actinobacteria,4CQFE@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase, class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
DYD2_k127_2147034_6	1205680.CAKO01000040_gene813	7.836e-11	68.0	COG1872@1|root,COG1872@2|Bacteria,1NGWG@1224|Proteobacteria,2UKJF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
DYD2_k127_2147034_4	760568.Desku_0244	5.077e-34	138.0	COG1525@1|root,COG1525@2|Bacteria,1VASF@1239|Firmicutes,24G14@186801|Clostridia,261ZZ@186807|Peptococcaceae	186801|Clostridia	L	PFAM nuclease (SNase	nucH	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	Ada_Zn_binding,SNase
DYD2_k127_2147034_7	1452536.JARE01000030_gene1067	2.544e-07	57.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria,4FQEB@85023|Microbacteriaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
DYD2_k127_2147034_8	1288083.AUKR01000009_gene1954	0.0002488	47.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
DYD2_k127_2147034_0	404589.Anae109_1879	2.205e-145	471.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2YU99@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
DYD2_k127_2147034_3	1123320.KB889714_gene8123	9.766e-69	237.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria	201174|Actinobacteria	E	Acetolactate synthase	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
DYD2_k127_2147034_2	1121877.JQKF01000003_gene1461	7.892e-97	323.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CMWQ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DYD2_k127_2151311_2	2754.EH55_10330	6.057e-39	147.0	COG0537@1|root,COG0537@2|Bacteria,3TB29@508458|Synergistetes	508458|Synergistetes	FG	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
DYD2_k127_2151311_1	1267535.KB906767_gene3817	1.832e-39	154.0	COG5611@1|root,COG5611@2|Bacteria	2|Bacteria	S	PIN domain	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_2151311_0	1303518.CCALI_02875	8.432e-194	626.0	COG0480@1|root,COG0480@2|Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DYD2_k127_2154582_2	1121939.L861_19245	3.402e-64	226.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1SZ0M@1236|Gammaproteobacteria,1XKZK@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
DYD2_k127_2154582_0	195250.CM001776_gene1129	4.995e-159	517.0	COG1012@1|root,COG1012@2|Bacteria,1G2U1@1117|Cyanobacteria,1GYU6@1129|Synechococcus	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
DYD2_k127_2154582_1	383372.Rcas_3505	4.658e-67	233.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DYD2_k127_2158046_0	1229780.BN381_160033	1.656e-168	540.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,3UWBE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
DYD2_k127_2158046_1	1123320.KB889574_gene5620	2.026e-110	374.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
DYD2_k127_2158046_2	1121422.AUMW01000007_gene3132	4.945e-83	286.0	COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,24ACH@186801|Clostridia,260X8@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
DYD2_k127_2158046_4	768706.Desor_3194	1.17e-21	108.0	COG0739@1|root,COG0739@2|Bacteria,1TQMQ@1239|Firmicutes,24B3J@186801|Clostridia,261N2@186807|Peptococcaceae	186801|Clostridia	M	PFAM Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
DYD2_k127_2158046_3	196162.Noca_3118	1.005e-39	151.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4DR34@85009|Propionibacteriales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
DYD2_k127_2161535_0	1112204.GPOL_c13270	5.963e-33	139.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,4GBC5@85026|Gordoniaceae	201174|Actinobacteria	EGP	MFS/sugar transport protein	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DYD2_k127_2161535_1	1206730.BAGA01000070_gene1628	6.595e-09	66.0	COG2267@1|root,COG2267@2|Bacteria,2GNJU@201174|Actinobacteria,4G07R@85025|Nocardiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
DYD2_k127_2161535_2	525904.Tter_0441	4.835e-05	51.0	COG2385@1|root,COG2385@2|Bacteria,2NRF5@2323|unclassified Bacteria	2|Bacteria	D	Stage II sporulation protein	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Amidase_2,Amidase_3,ChW,SpoIID
DYD2_k127_2168786_4	1305732.JAGG01000001_gene225	2.719e-25	110.0	COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,4FP3G@85023|Microbacteriaceae	201174|Actinobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
DYD2_k127_2168786_3	263358.VAB18032_02730	7.312e-33	138.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4DABD@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
DYD2_k127_2168786_0	1408436.JHXY01000012_gene1737	2.376e-78	270.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,25URM@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
DYD2_k127_2168786_1	1274374.CBLK010000047_gene2001	3.777e-46	169.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,4HIV1@91061|Bacilli,26XCJ@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
DYD2_k127_2168786_2	1121363.KB902185_gene298	1.897e-35	145.0	COG0157@1|root,COG0157@2|Bacteria,2GV9P@201174|Actinobacteria,22RB0@1653|Corynebacteriaceae	201174|Actinobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
DYD2_k127_2174719_0	1205910.B005_0061	0.0	1287.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4EGV8@85012|Streptosporangiales	201174|Actinobacteria	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
DYD2_k127_2174719_2	1463820.JOGW01000004_gene4574	1.194e-50	199.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria	201174|Actinobacteria	C	electron transfer subunit	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
DYD2_k127_2174719_1	1121422.AUMW01000022_gene1587	3.515e-90	306.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,260Y3@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DYD2_k127_2174719_3	1111479.AXAR01000004_gene2084	6.052e-48	182.0	COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,4HAJ2@91061|Bacilli,278CH@186823|Alicyclobacillaceae	91061|Bacilli	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
DYD2_k127_2174719_4	290317.Cpha266_2571	3.917e-43	171.0	COG0461@1|root,COG0461@2|Bacteria,1FDU8@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
DYD2_k127_2174719_5	553207.HMPREF0299_6486	2.709e-25	113.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,22NIS@1653|Corynebacteriaceae	201174|Actinobacteria	J	integration host factor	mihF	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2180159_0	1125863.JAFN01000001_gene244	9.81e-119	401.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ABC transporter	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DYD2_k127_2180159_5	316057.RPD_0463	4.738e-24	108.0	COG0432@1|root,COG0432@2|Bacteria,1Q3WU@1224|Proteobacteria,2U9MM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
DYD2_k127_2180159_2	1148.1001789	9.159e-78	285.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria,1H61N@1142|Synechocystis	1117|Cyanobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS_3,PAS_9
DYD2_k127_2180159_3	1380390.JIAT01000010_gene3626	6.006e-62	226.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4CPZ3@84995|Rubrobacteria	84995|Rubrobacteria	G	Inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
DYD2_k127_2180159_4	500153.JOEK01000014_gene5678	1.396e-28	124.0	COG2050@1|root,COG2050@2|Bacteria,2IKTU@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_2180159_6	1227495.C487_11851	3.175e-09	61.0	COG3360@1|root,arCOG04561@2157|Archaea,2XZVN@28890|Euryarchaeota,23Y3V@183963|Halobacteria	183963|Halobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
DYD2_k127_2180159_1	469371.Tbis_0176	4.95e-80	274.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4DZBP@85010|Pseudonocardiales	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DYD2_k127_2227343_0	1288079.AUKN01000001_gene4071	1.972e-40	164.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
DYD2_k127_2227343_2	1009370.ALO_12746	9.391e-08	60.0	COG3172@1|root,COG3172@2|Bacteria,1VQ43@1239|Firmicutes	1239|Firmicutes	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
DYD2_k127_2227343_1	391625.PPSIR1_13375	2.505e-12	77.0	COG3356@1|root,COG3356@2|Bacteria,1Q66U@1224|Proteobacteria,4358C@68525|delta/epsilon subdivisions,2WZJF@28221|Deltaproteobacteria,2Z29I@29|Myxococcales	28221|Deltaproteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
DYD2_k127_2227586_3	321327.CYA_0300	5.429e-21	93.0	COG1977@1|root,COG1977@2|Bacteria,1G86C@1117|Cyanobacteria,1H152@1129|Synechococcus	1117|Cyanobacteria	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DYD2_k127_2227586_2	264732.Moth_1653	1.886e-28	119.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,42GCN@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM transcriptional regulator, Rrf2 family	cymR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
DYD2_k127_2227586_0	469383.Cwoe_5791	5.86e-78	274.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4CPSB@84995|Rubrobacteria	84995|Rubrobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DYD2_k127_2227586_4	926569.ANT_02840	5.437e-11	71.0	COG2931@1|root,COG2931@2|Bacteria,2G9JH@200795|Chloroflexi	200795|Chloroflexi	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
DYD2_k127_2227586_1	1380390.JIAT01000010_gene3955	9.804e-35	150.0	COG0681@1|root,COG0681@2|Bacteria,2IDET@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF5305,Peptidase_S24
DYD2_k127_2234134_1	469371.Tbis_1120	9.939e-168	543.0	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria	201174|Actinobacteria	M	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
DYD2_k127_2234134_3	471857.Svir_27810	1.107e-19	95.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,4E4K7@85010|Pseudonocardiales	201174|Actinobacteria	S	Modulates RecA activity	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
DYD2_k127_2234134_2	909613.UO65_6440	2.016e-160	515.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4DZ5K@85010|Pseudonocardiales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
DYD2_k127_2234134_4	1499967.BAYZ01000181_gene4488	2.385e-10	73.0	COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
DYD2_k127_2234134_0	1380390.JIAT01000013_gene145	5.417e-176	591.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
DYD2_k127_2254584_2	1283299.AUKG01000002_gene4966	4.323e-112	375.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria	84995|Rubrobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
DYD2_k127_2254584_3	1172188.KB911820_gene2550	1.146e-39	158.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,4FFYF@85021|Intrasporangiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
DYD2_k127_2254584_1	292459.STH1810	1.719e-130	443.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18870	Orn_Arg_deC_N,Orn_DAP_Arg_deC
DYD2_k127_2254584_0	351607.Acel_0628	4.225e-143	472.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4ERR2@85013|Frankiales	201174|Actinobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DYD2_k127_2254584_4	106370.Francci3_3728	2.019e-34	138.0	COG0745@1|root,COG0745@2|Bacteria,2I2Z1@201174|Actinobacteria,4ETFB@85013|Frankiales	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_2254584_5	1267535.KB906767_gene4941	4.15e-17	94.0	COG1595@1|root,COG1595@2|Bacteria,3Y5K8@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_2266056_2	1133850.SHJG_7339	5.226e-07	60.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C
DYD2_k127_2266056_1	1219045.BV98_002860	3.945e-62	229.0	COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,2KCQ7@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
DYD2_k127_2266056_0	555793.WSK_3610	5.806e-98	327.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K4UJ@204457|Sphingomonadales	204457|Sphingomonadales	C	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_2312495_10	1200792.AKYF01000027_gene420	7.909e-36	149.0	COG0438@1|root,COG0438@2|Bacteria,1TT92@1239|Firmicutes,4HCQ5@91061|Bacilli,26ZTA@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_2312495_3	396014.BF93_17960	3.238e-89	309.0	COG0438@1|root,COG0438@2|Bacteria,2IMDW@201174|Actinobacteria	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
DYD2_k127_2312495_7	1211579.PP4_39750	3.704e-52	203.0	COG0438@1|root,COG0438@2|Bacteria,1MYJ6@1224|Proteobacteria,1S89E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_2312495_9	557598.LHK_02787	8.84e-41	167.0	COG0438@1|root,COG0438@2|Bacteria,1MYJ6@1224|Proteobacteria,2WF2I@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2312495_6	367299.JOEE01000003_gene2998	5.364e-53	214.0	COG2385@1|root,COG5479@1|root,COG2385@2|Bacteria,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4FJZJ@85021|Intrasporangiaceae	201174|Actinobacteria	DM	Stage II sporulation protein	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,FG-GAP
DYD2_k127_2312495_4	591157.SSLG_04020	1.477e-82	284.0	COG0377@1|root,COG0377@2|Bacteria,2GJP5@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB2	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
DYD2_k127_2312495_8	1394178.AWOO02000003_gene2834	2.321e-42	162.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria,4EIQ6@85012|Streptosporangiales	201174|Actinobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
DYD2_k127_2312495_1	479435.Kfla_6453	1.802e-128	430.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4DSY9@85009|Propionibacteriales	201174|Actinobacteria	C	Belongs to the complex I 49 kDa subunit family	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
DYD2_k127_2312495_2	479433.Caci_0848	7.745e-116	381.0	COG1005@1|root,COG1005@2|Bacteria,2GN3R@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH2	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
DYD2_k127_2312495_5	1160718.SU9_16512	1.42e-74	261.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
DYD2_k127_2312495_11	1463881.KL591014_gene715	1.476e-33	137.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
DYD2_k127_2312495_12	1449347.JQLN01000005_gene5323	5.563e-25	118.0	COG0713@1|root,COG0713@2|Bacteria,2IHNW@201174|Actinobacteria,2M386@2063|Kitasatospora	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
DYD2_k127_2312495_0	266117.Rxyl_1627	3.06e-149	496.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CPCM@84995|Rubrobacteria	84995|Rubrobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
DYD2_k127_231421_1	867903.ThesuDRAFT_01667	9.516e-60	214.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,3WCDX@538999|Clostridiales incertae sedis	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
DYD2_k127_231421_4	1128111.HMPREF0870_00574	6.012e-33	132.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4H4A5@909932|Negativicutes	909932|Negativicutes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
DYD2_k127_231421_2	1313172.YM304_19370	6.39e-52	191.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4CN5M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
DYD2_k127_231421_5	477641.MODMU_2667	2.592e-24	110.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4ESCD@85013|Frankiales	201174|Actinobacteria	K	SMART regulatory protein, MerR	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
DYD2_k127_231421_6	656024.FsymDg_3124	1.03e-11	71.0	2E49S@1|root,32RRE@2|Bacteria,2I83P@201174|Actinobacteria,4ETFD@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
DYD2_k127_231421_3	1246995.AFR_37065	1.87e-42	171.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4D8V8@85008|Micromonosporales	201174|Actinobacteria	I	enoyl-CoA hydratase	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
DYD2_k127_231421_0	644283.Micau_4490	4.257e-114	381.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4D8ZI@85008|Micromonosporales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
DYD2_k127_2334702_1	1121866.AUGK01000004_gene80	8.12e-65	240.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4CUGG@84998|Coriobacteriia	84998|Coriobacteriia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
DYD2_k127_2334702_0	656024.FsymDg_1644	8.332e-118	390.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4ERX9@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
DYD2_k127_2334702_2	1206741.BAFX01000118_gene7378	6.853e-32	140.0	COG0515@1|root,COG3055@1|root,COG0515@2|Bacteria,COG3055@2|Bacteria,2HEN9@201174|Actinobacteria,4FVW7@85025|Nocardiaceae	201174|Actinobacteria	KLT	Galactose oxidase, central domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Kelch_1,Pkinase
DYD2_k127_2351804_1	1122925.KB895409_gene1852	5.309e-27	128.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,26T15@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like
DYD2_k127_2351804_0	1120948.KB903246_gene3198	1.895e-40	159.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4DYAZ@85010|Pseudonocardiales	201174|Actinobacteria	T	Belongs to the peptidase S16 family	lon	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
DYD2_k127_2433582_3	330214.NIDE3382	3.052e-13	73.0	2ECCV@1|root,336B4@2|Bacteria,3J18G@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2433582_1	35754.JNYJ01000007_gene2855	3.851e-27	122.0	2DPD0@1|root,331J4@2|Bacteria,2IFZU@201174|Actinobacteria,4DCU1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2433582_0	1445613.JALM01000010_gene2284	2.27e-47	177.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4E2X5@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM AhpC TSA family	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
DYD2_k127_2433582_2	1177154.Y5S_00900	3.501e-25	119.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1XPNY@135619|Oceanospirillales	135619|Oceanospirillales	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
DYD2_k127_245574_1	1041139.KB902635_gene3847	7.694e-05	53.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
DYD2_k127_245574_0	1229780.BN381_10243	2.191e-216	711.0	COG0410@1|root,COG0411@1|root,COG0410@2|Bacteria,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DYD2_k127_252217_1	2002.JOEQ01000003_gene2428	2.68e-24	103.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4EGP6@85012|Streptosporangiales	201174|Actinobacteria	O	Clp amino terminal domain, pathogenicity island component	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
DYD2_k127_252217_0	1415780.JPOG01000001_gene2311	6.573e-169	549.0	28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,1RP4W@1236|Gammaproteobacteria,1X5NC@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2567819_0	298655.KI912267_gene6625	1.216e-138	460.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4ERJ5@85013|Frankiales	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
DYD2_k127_2567819_1	1283287.KB822577_gene3218	1.9e-68	255.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DTUR@85009|Propionibacteriales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
DYD2_k127_2567819_2	1211815.CBYP010000020_gene1746	3.281e-12	79.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_4,PAS_9,Peripla_BP_3
DYD2_k127_2596066_1	33876.JNXY01000033_gene2195	2.813e-06	54.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4DDIS@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
DYD2_k127_2596066_0	68170.KL590535_gene3736	7.235e-39	152.0	COG3439@1|root,COG3439@2|Bacteria,2IKVF@201174|Actinobacteria,4E4ZR@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
DYD2_k127_263589_0	1035308.AQYY01000001_gene2439	3.636e-92	318.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,260C9@186807|Peptococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DYD2_k127_263589_1	1313172.YM304_21500	2.477e-31	141.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Beta_helix,Flg_new,HYR
DYD2_k127_2674136_9	1449068.JMLQ01000014_gene4267	6.49e-13	82.0	COG3764@1|root,COG3764@2|Bacteria,2I91T@201174|Actinobacteria,4FZ24@85025|Nocardiaceae	201174|Actinobacteria	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
DYD2_k127_2674136_3	1123024.AUII01000052_gene3914	4.182e-67	235.0	COG0500@1|root,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria,4EEKA@85010|Pseudonocardiales	201174|Actinobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
DYD2_k127_2674136_4	469383.Cwoe_5547	3.347e-60	214.0	COG1719@1|root,COG1719@2|Bacteria	2|Bacteria	KT	4-vinyl reductase, 4VR	-	-	-	-	-	-	-	-	-	-	-	-	HNOB
DYD2_k127_2674136_6	134676.ACPL_4605	2.439e-43	169.0	COG0642@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2GZZR@201174|Actinobacteria,4DGR5@85008|Micromonosporales	201174|Actinobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9
DYD2_k127_2674136_0	196162.Noca_2108	1.354e-284	894.0	COG2936@1|root,COG2936@2|Bacteria,2IAA6@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_2674136_8	1121272.KB903250_gene3064	6.026e-14	75.0	COG5398@1|root,COG5398@2|Bacteria,2H90I@201174|Actinobacteria,4DDZX@85008|Micromonosporales	201174|Actinobacteria	P	Heme oxygenase	hmuO	-	1.14.15.20	ko:K21480	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R11579	RC01270	ko00000,ko00001,ko01000	-	-	-	Heme_oxygenase
DYD2_k127_2674136_5	710686.Mycsm_03411	1.239e-46	177.0	28SI0@1|root,2ZEUB@2|Bacteria,2GNT0@201174|Actinobacteria,23A83@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867
DYD2_k127_2674136_1	1380390.JIAT01000014_gene6208	2.909e-224	713.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,NB-ARC,Response_reg,TIR_2,TPR_10,TPR_12
DYD2_k127_2674136_2	1123024.AUII01000016_gene1274	8.392e-206	647.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4DZ4D@85010|Pseudonocardiales	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
DYD2_k127_2674136_7	1068978.AMETH_4234	2.038e-38	148.0	COG1977@1|root,COG1977@2|Bacteria,2IQJJ@201174|Actinobacteria,4E613@85010|Pseudonocardiales	201174|Actinobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
DYD2_k127_2675968_1	1048339.KB913029_gene3712	2.888e-117	382.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
DYD2_k127_2675968_0	656024.FsymDg_4517	2.554e-149	483.0	COG1373@1|root,COG1373@2|Bacteria,2GK1Q@201174|Actinobacteria	201174|Actinobacteria	J	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
DYD2_k127_2675968_2	1906.SFRA_32250	1.074e-75	264.0	COG1741@1|root,COG1741@2|Bacteria,2GM9P@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
DYD2_k127_2675968_3	1125863.JAFN01000001_gene2884	1.579e-23	103.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Cold-shock protein, DNA-binding	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
DYD2_k127_2675968_4	1068980.ARVW01000001_gene6829	4.147e-09	63.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4E03N@85010|Pseudonocardiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_2701553_0	1440053.JOEI01000004_gene3802	7.565e-08	65.0	COG5640@1|root,COG5640@2|Bacteria,2GN4T@201174|Actinobacteria	201174|Actinobacteria	O	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,VCBS
DYD2_k127_2702982_3	656024.FsymDg_3117	7.351e-116	394.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
DYD2_k127_2702982_0	1122939.ATUD01000023_gene3961	1.341e-133	443.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CP75@84995|Rubrobacteria	84995|Rubrobacteria	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DYD2_k127_2702982_4	266940.Krad_3203	6.314e-100	342.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DYD2_k127_2702982_2	1211815.CBYP010000010_gene3718	5.807e-117	386.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4ERUH@85013|Frankiales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
DYD2_k127_2702982_6	365528.KB891102_gene4419	3.802e-74	270.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4ERI0@85013|Frankiales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
DYD2_k127_2702982_5	1122611.KB903978_gene3345	1.018e-81	291.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4EI9C@85012|Streptosporangiales	201174|Actinobacteria	D	Cell cycle protein	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
DYD2_k127_2702982_7	66377.JOBH01000009_gene4938	4.139e-70	255.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
DYD2_k127_2702982_1	477641.MODMU_3454	4.274e-123	411.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4ERUC@85013|Frankiales	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
DYD2_k127_2702982_8	1120971.AUCA01000030_gene30	1.559e-55	205.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,2785S@186823|Alicyclobacillaceae	91061|Bacilli	M	Cell wall formation	murB	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
DYD2_k127_2702982_9	1283287.KB822576_gene3773	9.468e-10	70.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4DRPK@85009|Propionibacteriales	201174|Actinobacteria	D	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
DYD2_k127_2708856_1	1322246.BN4_12377	5.982e-24	111.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2M9B2@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
DYD2_k127_2708856_0	913865.DOT_4404	3.524e-99	333.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2615C@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM Ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
DYD2_k127_2712076_0	266117.Rxyl_0583	1.124e-179	570.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,4CRM0@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
DYD2_k127_2712076_5	1906.SFRA_11050	7.527e-13	71.0	2DU71@1|root,33P6J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2712076_1	1463934.JOCF01000047_gene998	2.22e-88	308.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria	201174|Actinobacteria	Q	Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
DYD2_k127_2712076_6	1227352.C173_05921	3.72e-07	60.0	2E9CG@1|root,333K5@2|Bacteria,1V87Y@1239|Firmicutes,4HIGZ@91061|Bacilli,26ZX6@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIMP
DYD2_k127_2712076_2	401526.TcarDRAFT_0360	8.564e-80	283.0	COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,4H2JX@909932|Negativicutes	909932|Negativicutes	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
DYD2_k127_2712076_3	298654.FraEuI1c_1783	1.513e-40	153.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4ESRR@85013|Frankiales	201174|Actinobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
DYD2_k127_2712076_4	1282876.BAOK01000002_gene356	1.293e-38	153.0	COG3217@1|root,COG3217@2|Bacteria,1N1P0@1224|Proteobacteria,2UH9P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MOSC domain containing protein	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
DYD2_k127_2712702_0	1306174.JODP01000016_gene7073	3.381e-150	503.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
DYD2_k127_2712702_3	1386089.N865_20610	3.319e-08	61.0	COG1366@1|root,COG1366@2|Bacteria,2HWZB@201174|Actinobacteria,4FHCU@85021|Intrasporangiaceae	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
DYD2_k127_2712702_1	1227739.Hsw_2747	9.905e-16	84.0	COG2318@1|root,COG2318@2|Bacteria,4NNQI@976|Bacteroidetes,47QCG@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
DYD2_k127_2712702_2	649747.HMPREF0083_00287	6.143e-11	70.0	COG2318@1|root,COG2318@2|Bacteria,1V8HE@1239|Firmicutes,4HJ3X@91061|Bacilli,272R9@186822|Paenibacillaceae	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
DYD2_k127_2739355_0	1379270.AUXF01000005_gene495	1.864e-19	94.0	COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
DYD2_k127_2739355_1	31964.CMS0722	1.592e-17	89.0	COG0607@1|root,COG0607@2|Bacteria,2IQIP@201174|Actinobacteria,4FQF3@85023|Microbacteriaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
DYD2_k127_2739355_2	110319.CF8_0498	1.666e-13	79.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CBM_6,Cytochrom_C,LVIVD,Laminin_G_3,NPCBM,PA,PKD,RicinB_lectin_2,Ricin_B_lectin
DYD2_k127_277315_3	1278078.G419_14934	1.02e-18	96.0	COG1073@1|root,COG1073@2|Bacteria,2IFI1@201174|Actinobacteria,4FX9G@85025|Nocardiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
DYD2_k127_277315_0	1112204.GPOL_c13270	1.955e-54	207.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,4GBC5@85026|Gordoniaceae	201174|Actinobacteria	EGP	MFS/sugar transport protein	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DYD2_k127_277315_2	928724.SacglDRAFT_00703	2.062e-23	104.0	COG3427@1|root,COG3427@2|Bacteria,2II8Y@201174|Actinobacteria,4E5GT@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
DYD2_k127_277315_1	1111479.AXAR01000007_gene970	2.259e-41	160.0	COG2151@1|root,COG2151@2|Bacteria,1V3QG@1239|Firmicutes,4HHST@91061|Bacilli,279W6@186823|Alicyclobacillaceae	91061|Bacilli	S	Iron-sulfur cluster assembly protein	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
DYD2_k127_277315_4	1333523.L593_02405	3.363e-18	91.0	COG3396@1|root,arCOG04786@2157|Archaea,2XUT6@28890|Euryarchaeota,23T4K@183963|Halobacteria	183963|Halobacteria	Q	Phenylacetate-CoA oxygenase	paaC	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
DYD2_k127_2792223_2	479432.Sros_0536	9.258e-43	165.0	2EBHZ@1|root,335IE@2|Bacteria,2GNMR@201174|Actinobacteria,4EIF8@85012|Streptosporangiales	201174|Actinobacteria	S	Phosphatase	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	-	-	-	-	-	-	-	-	-	-	Phosphatase
DYD2_k127_2792223_1	471852.Tcur_4452	7.635e-119	395.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4EGFY@85012|Streptosporangiales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
DYD2_k127_2792223_0	643473.KB235930_gene2822	2.371e-177	572.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,1HMNK@1161|Nostocales	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79	ko:K00128,ko:K00135,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DYD2_k127_2792223_3	709986.Deima_1123	2.917e-09	60.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DYD2_k127_280119_3	1236902.ANAS01000019_gene4113	2.043e-49	193.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4EIHA@85012|Streptosporangiales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
DYD2_k127_280119_2	1121422.AUMW01000035_gene2650	8.533e-73	253.0	COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,249VX@186801|Clostridia,260BB@186807|Peptococcaceae	186801|Clostridia	K	RNA polymerase sigma factor, sigma-70 family	sigH	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	GerE,Sigma70_r2,Sigma70_r4_2
DYD2_k127_280119_0	1382306.JNIM01000001_gene3513	3.995e-153	494.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DYD2_k127_280119_4	2002.JOEQ01000052_gene8361	1.449e-23	102.0	2CUM0@1|root,32SVJ@2|Bacteria,2IQG7@201174|Actinobacteria,4EK6A@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3263
DYD2_k127_280119_6	1487921.DP68_08410	0.0002749	50.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,36FHF@31979|Clostridiaceae	186801|Clostridia	K	cell envelope-related function transcriptional attenuator	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
DYD2_k127_280119_1	1283299.AUKG01000006_gene752	3.672e-87	299.0	COG0438@1|root,COG0438@2|Bacteria,2I005@201174|Actinobacteria,4CR8E@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_280119_5	1236902.ANAS01000005_gene4580	8.773e-19	94.0	COG1877@1|root,COG1877@2|Bacteria,2GMKW@201174|Actinobacteria,4EII2@85012|Streptosporangiales	201174|Actinobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
DYD2_k127_2810335_1	40571.JOEA01000005_gene4000	2.341e-84	286.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4E1QJ@85010|Pseudonocardiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
DYD2_k127_2810335_0	1123321.KB905814_gene2045	2.997e-110	381.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DYD2_k127_2859537_1	337191.KTR9_3311	6.927e-60	216.0	COG0500@1|root,COG2226@2|Bacteria,2HX2T@201174|Actinobacteria,4GC8H@85026|Gordoniaceae	201174|Actinobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DYD2_k127_2859537_0	1122138.AQUZ01000108_gene8363	1.056e-95	320.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4DNJS@85009|Propionibacteriales	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
DYD2_k127_2859537_2	479432.Sros_6378	0.0003231	53.0	COG3391@1|root,COG3391@2|Bacteria,2HF6F@201174|Actinobacteria,4EPN7@85012|Streptosporangiales	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2886572_1	1122132.AQYH01000007_gene1825	4.282e-28	121.0	COG0494@1|root,COG0494@2|Bacteria,1RM2Y@1224|Proteobacteria,2UAF2@28211|Alphaproteobacteria,4BFSH@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_2886572_2	91464.S7335_2861	2.815e-16	78.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1GZDZ@1129|Synechococcus	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
DYD2_k127_2886572_0	1192034.CAP_4583	3.553e-201	649.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2YU7A@29|Myxococcales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
DYD2_k127_2890126_1	1220583.GOACH_03_05060	9.047e-13	81.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4GD92@85026|Gordoniaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
DYD2_k127_2890126_0	1463854.JOHT01000012_gene4575	4.036e-212	690.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria	201174|Actinobacteria	T	UPF0182 protein	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
DYD2_k127_2914376_1	690850.Desaf_0734	1.48e-45	182.0	COG0438@1|root,COG0438@2|Bacteria,1PERD@1224|Proteobacteria,42VK8@68525|delta/epsilon subdivisions,2WSBY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_2914376_0	357808.RoseRS_1135	1.707e-86	300.0	COG0673@1|root,COG0673@2|Bacteria,2G6Y0@200795|Chloroflexi,376NR@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DYD2_k127_2914376_2	888439.HMPREF9240_00708	5.692e-12	70.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,4D3DD@85005|Actinomycetales	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	wecC	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DYD2_k127_2945305_3	110319.CF8_1483	1.438e-70	265.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4DPUK@85009|Propionibacteriales	201174|Actinobacteria	Q	Multicopper oxidase	cotA	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
DYD2_k127_2945305_5	644282.Deba_2816	6.593e-42	164.0	2FCUT@1|root,344XR@2|Bacteria,1P20K@1224|Proteobacteria,4320S@68525|delta/epsilon subdivisions,2WWIJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2945305_0	1463856.JOHY01000008_gene915	1.656e-234	731.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
DYD2_k127_2945305_1	744980.TRICHSKD4_3508	1.282e-199	673.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Hint_2
DYD2_k127_2945305_2	1089553.Tph_c16140	7.973e-71	252.0	COG3502@1|root,COG3502@2|Bacteria,1TQW1@1239|Firmicutes,24952@186801|Clostridia,42F42@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
DYD2_k127_2945305_6	1095767.CAHD01000208_gene140	1.177e-21	107.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4F0RH@85016|Cellulomonadaceae	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
DYD2_k127_2945305_4	298655.KI912266_gene3646	5.811e-56	210.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4ESDG@85013|Frankiales	201174|Actinobacteria	K	WYL domain	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
DYD2_k127_2956503_0	1229203.KI301992_gene1995	4.015e-234	744.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,3UWC5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
DYD2_k127_2956503_1	67257.JODR01000029_gene3026	2.849e-17	94.0	COG5479@1|root,COG5479@2|Bacteria,2GMJR@201174|Actinobacteria	201174|Actinobacteria	M	Protein of unknown function (DUF3152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3152
DYD2_k127_2977982_3	1229203.KI301992_gene1794	6.636e-14	82.0	2F0KN@1|root,33TPA@2|Bacteria,2H2B7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2977982_0	1157637.KB892110_gene4315	2.662e-150	484.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_2977982_2	356851.JOAN01000024_gene4509	1.268e-19	102.0	29V0V@1|root,30GDY@2|Bacteria,2ICUU@201174|Actinobacteria,4DDYB@85008|Micromonosporales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
DYD2_k127_2977982_1	1121272.KB903293_gene7258	4.462e-43	164.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4D9AA@85008|Micromonosporales	201174|Actinobacteria	I	Maoc domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
DYD2_k127_3020363_1	1146883.BLASA_1057	1.588e-48	192.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4EVZ3@85013|Frankiales	201174|Actinobacteria	T	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
DYD2_k127_3020363_0	1385518.N798_16405	8.948e-123	406.0	COG0664@1|root,COG0664@2|Bacteria,2ID3H@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
DYD2_k127_3029802_1	110319.CF8_0498	3.792e-32	142.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CBM_6,Cytochrom_C,LVIVD,Laminin_G_3,NPCBM,PA,PKD,RicinB_lectin_2,Ricin_B_lectin
DYD2_k127_3029802_0	2002.JOEQ01000006_gene1466	2.348e-152	493.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4EHP0@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
DYD2_k127_303710_3	543632.JOJL01000009_gene5974	3.45e-53	211.0	2EZ1U@1|root,33S89@2|Bacteria,2I9C0@201174|Actinobacteria,4DIFA@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
DYD2_k127_303710_5	1122138.AQUZ01000044_gene4530	5.517e-05	54.0	2CCSB@1|root,33USJ@2|Bacteria,2IPHH@201174|Actinobacteria,4DUGV@85009|Propionibacteriales	201174|Actinobacteria	S	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
DYD2_k127_303710_4	1463895.JODA01000033_gene3072	2.605e-17	90.0	2C1B5@1|root,3404V@2|Bacteria,2IQAF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
DYD2_k127_303710_2	1122138.AQUZ01000044_gene4532	4.641e-127	426.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4DPSR@85009|Propionibacteriales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DYD2_k127_303710_0	1157638.KB892165_gene3609	1.483e-205	655.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DYD2_k127_303710_1	526225.Gobs_4765	3.474e-156	507.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,4ERE3@85013|Frankiales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DYD2_k127_3063316_10	861299.J421_0272	9.365e-19	91.0	COG2197@1|root,COG2197@2|Bacteria,1ZTJ5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DYD2_k127_3063316_8	1120950.KB892707_gene4709	2.603e-27	128.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
DYD2_k127_3063316_9	345341.KUTG_04140	1.837e-24	111.0	2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3063316_4	1078020.KEK_05942	6.623e-34	135.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,234GG@1762|Mycobacteriaceae	201174|Actinobacteria	GL	Ribonuclease	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
DYD2_k127_3063316_3	1288079.AUKN01000003_gene3882	2.21e-41	162.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria	201174|Actinobacteria	S	Zn-ribbon protein, possibly nucleic acid-binding	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
DYD2_k127_3063316_6	292459.STH2528	2.803e-30	126.0	COG1595@1|root,COG1595@2|Bacteria,1VD37@1239|Firmicutes,25BCE@186801|Clostridia	186801|Clostridia	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
DYD2_k127_3063316_5	479433.Caci_4867	1.119e-33	138.0	COG5592@1|root,COG5592@2|Bacteria,2IGW0@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
DYD2_k127_3063316_7	1048339.KB913029_gene4039	1.003e-27	130.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3063316_1	1894.JOER01000036_gene3141	1.168e-52	192.0	COG1683@1|root,COG1683@2|Bacteria,2IJAV@201174|Actinobacteria	201174|Actinobacteria	F	Protein of unknown function (DUF523)	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF523,PNP_UDP_1
DYD2_k127_3063316_11	298654.FraEuI1c_1851	1.959e-16	81.0	2E5NJ@1|root,330DC@2|Bacteria,2IREF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3063316_2	909613.UO65_3289	4.021e-46	175.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4E2X5@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM AhpC TSA family	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
DYD2_k127_3063316_0	557599.MKAN_18365	2.022e-64	235.0	COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria,23F02@1762|Mycobacteriaceae	201174|Actinobacteria	E	oxidoreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
DYD2_k127_3103252_3	1370121.AUWS01000026_gene3148	1.835e-106	359.0	COG1921@1|root,COG1921@2|Bacteria,2HFGK@201174|Actinobacteria,23416@1762|Mycobacteriaceae	201174|Actinobacteria	E	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
DYD2_k127_3103252_15	1043205.AFYF01000021_gene822	4.198e-20	102.0	COG0454@1|root,COG0456@2|Bacteria,2I2E3@201174|Actinobacteria	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_3103252_13	935839.JAGJ01000008_gene1689	5.069e-28	126.0	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria,4F5ZQ@85017|Promicromonosporaceae	201174|Actinobacteria	M	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_3103252_2	2045.KR76_07185	4.426e-114	390.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4DP4G@85009|Propionibacteriales	201174|Actinobacteria	J	Elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
DYD2_k127_3103252_9	2002.JOEQ01000043_gene5972	6.2e-42	166.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4EJ25@85012|Streptosporangiales	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
DYD2_k127_3103252_16	1385521.N803_09810	5.093e-14	75.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria,4FHQA@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
DYD2_k127_3103252_14	1385519.N801_18770	3.454e-22	98.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,4FH9Q@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
DYD2_k127_3103252_11	479434.Sthe_1855	2.08e-35	151.0	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi,27XU8@189775|Thermomicrobia	189775|Thermomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
DYD2_k127_3103252_7	1869.MB27_38605	8.818e-55	212.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4DAB7@85008|Micromonosporales	201174|Actinobacteria	P	Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
DYD2_k127_3103252_5	1120934.KB894418_gene2022	1.307e-87	314.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4E064@85010|Pseudonocardiales	201174|Actinobacteria	D	PFAM Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
DYD2_k127_3103252_1	1009370.ALO_05048	7.085e-117	406.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H6ME@909932|Negativicutes	909932|Negativicutes	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
DYD2_k127_3103252_10	1123251.ATWM01000007_gene2339	1.856e-37	147.0	COG1610@1|root,COG1610@2|Bacteria,2IFFJ@201174|Actinobacteria,4FGNG@85021|Intrasporangiaceae	201174|Actinobacteria	S	GatB YqeY domain-containing protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
DYD2_k127_3103252_6	644283.Micau_5929	9.795e-66	239.0	COG1408@1|root,COG1408@2|Bacteria,2GJHT@201174|Actinobacteria,4D9XH@85008|Micromonosporales	201174|Actinobacteria	S	Metallophosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
DYD2_k127_3103252_4	1254432.SCE1572_09945	1.184e-100	350.0	COG5555@1|root,COG5555@2|Bacteria,1QX82@1224|Proteobacteria,43CYG@68525|delta/epsilon subdivisions,2X86M@28221|Deltaproteobacteria,2Z3M6@29|Myxococcales	28221|Deltaproteobacteria	N	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP
DYD2_k127_3103252_12	1128421.JAGA01000002_gene1074	6.552e-32	139.0	28HWT@1|root,2Z82P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Xpo1
DYD2_k127_3103252_0	926550.CLDAP_10980	3.378e-194	615.0	COG3033@1|root,COG3033@2|Bacteria,2G7YV@200795|Chloroflexi	200795|Chloroflexi	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tpl	-	4.1.99.1,4.1.99.2	ko:K01667,ko:K01668	ko00350,ko00380,map00350,map00380	-	R00673,R00728	RC00209,RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
DYD2_k127_3103252_17	671143.DAMO_2720	2.324e-06	57.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
DYD2_k127_3103252_18	1122139.KB907873_gene2739	1.778e-05	53.0	COG4691@1|root,COG4691@2|Bacteria,1N8BI@1224|Proteobacteria,1SDUR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Plasmid stability protein	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	Arc
DYD2_k127_3103252_8	298654.FraEuI1c_6805	1.092e-52	191.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria,4ESXG@85013|Frankiales	201174|Actinobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
DYD2_k127_3115717_5	1128421.JAGA01000003_gene2765	6.046e-41	161.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_3115717_3	1380354.JIAN01000006_gene1024	4.875e-62	221.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria	201174|Actinobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
DYD2_k127_3115717_4	1463853.JOHW01000018_gene5009	4.525e-50	197.0	COG1928@1|root,COG1928@2|Bacteria,2I2H1@201174|Actinobacteria	201174|Actinobacteria	O	PFAM glycosyl transferase family 39	pmt	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_4TMC
DYD2_k127_3115717_2	1386089.N865_09815	3.633e-65	234.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4FF19@85021|Intrasporangiaceae	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
DYD2_k127_3115717_8	1415779.JOMH01000001_gene281	5.176e-11	74.0	2EUZU@1|root,33NF1@2|Bacteria,1NK8D@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3115717_6	1415775.U729_801	1.022e-21	97.0	COG2002@1|root,COG2002@2|Bacteria,1VA3H@1239|Firmicutes,24MN7@186801|Clostridia,36KGI@31979|Clostridiaceae	186801|Clostridia	K	AbrB family	NPD5_2057	-	-	ko:K06284	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin
DYD2_k127_3115717_0	1120950.KB892810_gene7206	1.547e-184	594.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4DNQ0@85009|Propionibacteriales	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
DYD2_k127_3115717_1	1313172.YM304_33030	1.469e-66	252.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4CN2X@84992|Acidimicrobiia	84992|Acidimicrobiia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
DYD2_k127_3115717_7	106370.Francci3_1730	5.109e-12	76.0	COG1652@1|root,COG3629@1|root,COG1652@2|Bacteria,COG3629@2|Bacteria,2I8YV@201174|Actinobacteria	201174|Actinobacteria	NU	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,LysM,Trans_reg_C
DYD2_k127_3124848_0	1120936.KB907210_gene5949	1.25e-108	359.0	COG1073@1|root,COG1073@2|Bacteria,2I52S@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3124848_3	298654.FraEuI1c_0431	1.41e-22	102.0	COG2261@1|root,COG2261@2|Bacteria,2GS37@201174|Actinobacteria,4ETMQ@85013|Frankiales	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
DYD2_k127_3124848_1	219305.MCAG_01184	1.891e-67	238.0	COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria,4DDA7@85008|Micromonosporales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3124848_5	1121382.JQKG01000011_gene644	2.42e-12	78.0	2CA4F@1|root,33DCB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3124848_4	272942.RCAP_rcc02256	9.058e-22	98.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,1FBWS@1060|Rhodobacter	28211|Alphaproteobacteria	K	Two component transcriptional regulator, winged helix family	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DYD2_k127_3124848_2	266117.Rxyl_2663	2.479e-40	169.0	COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,2I2Y1@201174|Actinobacteria,4CU6E@84995|Rubrobacteria	201174|Actinobacteria	T	PFAM response regulator receiver ATP-binding region, ATPase-like histidine kinase A-like Hpt PAS fold-3 PAS fold-4 PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg
DYD2_k127_3148458_0	1415779.JOMH01000001_gene2126	3.058e-145	475.0	COG5276@1|root,COG5276@2|Bacteria,1R8ZW@1224|Proteobacteria,1S0TP@1236|Gammaproteobacteria,1X52T@135614|Xanthomonadales	135614|Xanthomonadales	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_3148458_3	1713.JOFV01000001_gene2049	1.368e-18	95.0	2E01T@1|root,32VQY@2|Bacteria,2IIWX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3148458_1	406552.NJ7G_3312	3.136e-113	381.0	COG0277@1|root,arCOG00340@2157|Archaea,2Y85H@28890|Euryarchaeota,24157@183963|Halobacteria	183963|Halobacteria	C	COG0277 FAD FMN-containing dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
DYD2_k127_3148458_2	196162.Noca_3592	3.361e-22	104.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4DRF9@85009|Propionibacteriales	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
DYD2_k127_3152548_0	1298880.AUEV01000014_gene3780	1.846e-97	328.0	COG2185@1|root,COG2185@2|Bacteria,2I2N3@201174|Actinobacteria	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	meaA	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
DYD2_k127_3152548_2	1003195.SCAT_2056	2.062e-42	162.0	COG1607@1|root,COG1607@2|Bacteria,2GK6X@201174|Actinobacteria	201174|Actinobacteria	I	Acyl-CoA hydrolase	-	-	3.1.2.23	ko:K01075,ko:K10806	ko00130,ko00362,ko01040,ko01100,ko01110,ko01120,map00130,map00362,map01040,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
DYD2_k127_3152548_1	591157.SSLG_04152	8.952e-53	203.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria	201174|Actinobacteria	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
DYD2_k127_3152548_3	326424.FRAAL1228	1.552e-08	62.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4ET4A@85013|Frankiales	201174|Actinobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DYD2_k127_3182328_0	471852.Tcur_1582	6.334e-275	864.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4EFUG@85012|Streptosporangiales	201174|Actinobacteria	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
DYD2_k127_3182328_1	477641.MODMU_5190	9.46e-69	248.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4EUP4@85013|Frankiales	201174|Actinobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
DYD2_k127_3182328_2	1385518.N798_14080	1.026e-17	90.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4FGC5@85021|Intrasporangiaceae	201174|Actinobacteria	L	COG1555 DNA uptake protein and related DNA-binding	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
DYD2_k127_3204173_2	1385515.N791_10880	7.014e-38	149.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,1RNYZ@1236|Gammaproteobacteria,1XAHH@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
DYD2_k127_3204173_3	28444.JODQ01000017_gene6543	1.233e-37	156.0	COG2380@1|root,COG2380@2|Bacteria,2I8F9@201174|Actinobacteria,4EI5H@85012|Streptosporangiales	201174|Actinobacteria	S	COGs COG2380 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3204173_0	512565.AMIS_67940	2.384e-177	578.0	COG0433@1|root,COG0433@2|Bacteria,2I0H5@201174|Actinobacteria,4D9TP@85008|Micromonosporales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_3204173_1	287986.DV20_15915	8.749e-70	257.0	COG0420@1|root,COG0420@2|Bacteria,2GK9R@201174|Actinobacteria,4DYUN@85010|Pseudonocardiales	201174|Actinobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
DYD2_k127_3234446_2	1380390.JIAT01000013_gene221	2.22e-85	293.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4CREI@84995|Rubrobacteria	84995|Rubrobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DYD2_k127_3234446_3	1380356.JNIK01000003_gene1236	5.165e-32	131.0	COG1672@1|root,COG1672@2|Bacteria,2IGAA@201174|Actinobacteria,4ET1R@85013|Frankiales	201174|Actinobacteria	S	Electron transfer DM13	-	-	-	-	-	-	-	-	-	-	-	-	DM13
DYD2_k127_3234446_1	1380347.JNII01000010_gene2475	1.334e-115	381.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4ES9F@85013|Frankiales	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
DYD2_k127_3234446_0	298653.Franean1_5970	1.097e-128	418.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4ESBM@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
DYD2_k127_3259163_0	1037409.BJ6T_56240	3.045e-141	464.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,3JTK8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc,Hydrolase_4,Trans_reg_C
DYD2_k127_3259163_1	1444309.JAQG01000004_gene3592	3.834e-22	103.0	COG2318@1|root,COG2318@2|Bacteria,1VW3T@1239|Firmicutes,4HWQI@91061|Bacilli,26Y17@186822|Paenibacillaceae	91061|Bacilli	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
DYD2_k127_3259163_2	208439.AJAP_20125	1.812e-18	89.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4E163@85010|Pseudonocardiales	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
DYD2_k127_3370613_2	479434.Sthe_0300	1.031e-67	242.0	COG1008@1|root,COG1008@2|Bacteria,2G5VU@200795|Chloroflexi,27XEU@189775|Thermomicrobia	189775|Thermomicrobia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
DYD2_k127_3370613_0	1120948.KB903217_gene1466	1.611e-163	535.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4DZ3C@85010|Pseudonocardiales	201174|Actinobacteria	CP	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
DYD2_k127_3370613_5	106370.Francci3_0548	8.188e-35	135.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4ET3I@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
DYD2_k127_3370613_4	365528.KB891252_gene5632	5.436e-39	151.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4ESIY@85013|Frankiales	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
DYD2_k127_3370613_3	1121272.KB903293_gene7396	2.04e-64	225.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4DATK@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
DYD2_k127_3370613_1	1449048.JQKU01000036_gene2954	3.552e-112	373.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,232KR@1762|Mycobacteriaceae	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	Fer4,NADHdh
DYD2_k127_3408028_2	525368.HMPREF0591_5107	8.602e-51	181.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,239CP@1762|Mycobacteriaceae	201174|Actinobacteria	C	ferredoxin	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4
DYD2_k127_3408028_3	1519464.HY22_00570	1.761e-27	121.0	COG2945@1|root,COG2945@2|Bacteria,1FF3C@1090|Chlorobi	1090|Chlorobi	S	Dienelactone hydrolase family	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_3408028_4	1435356.Y013_14200	7.729e-05	48.0	COG0454@1|root,COG0456@2|Bacteria,2H5WU@201174|Actinobacteria,4FUVF@85025|Nocardiaceae	201174|Actinobacteria	K	FR47-like protein	-	-	2.3.1.1	ko:K22476	ko00220,ko01210,ko01230,map00220,map01210,map01230	-	R00259	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,FR47
DYD2_k127_3408028_0	479432.Sros_8442	4.845e-128	426.0	COG0215@1|root,COG0215@2|Bacteria,2IDHB@201174|Actinobacteria,4EN5K@85012|Streptosporangiales	201174|Actinobacteria	J	tRNA synthetases class I (C) catalytic domain	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
DYD2_k127_3408028_1	1111479.AXAR01000005_gene458	2.186e-68	241.0	COG1063@1|root,COG1063@2|Bacteria,1TPIW@1239|Firmicutes,4HB2G@91061|Bacilli,278YF@186823|Alicyclobacillaceae	91061|Bacilli	E	Alcohol dehydrogenase GroES-associated	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
DYD2_k127_3416205_2	1033730.CAHG01000006_gene1002	7.887e-69	246.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4DNQY@85009|Propionibacteriales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
DYD2_k127_3416205_4	429009.Adeg_2060	9.992e-64	237.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,42F58@68295|Thermoanaerobacterales	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
DYD2_k127_3416205_3	1048339.KB913029_gene2249	1.972e-65	229.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4ESNA@85013|Frankiales	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DYD2_k127_3416205_0	298654.FraEuI1c_0306	1.059e-240	759.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4ERQQ@85013|Frankiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
DYD2_k127_3416205_5	471857.Svir_35640	1.113e-53	198.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4DXVF@85010|Pseudonocardiales	201174|Actinobacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
DYD2_k127_3416205_1	1123368.AUIS01000012_gene773	3.423e-81	280.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,2NBTN@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
DYD2_k127_3416205_6	397948.Cmaq_0517	1.44e-17	87.0	COG0801@1|root,arCOG07203@2157|Archaea	2157|Archaea	H	Dihydroneopterin aldolase	-	-	-	-	-	-	-	-	-	-	-	-	FolB,HPPK
DYD2_k127_3447308_10	478741.JAFS01000002_gene223	0.0001465	48.0	COG1005@1|root,COG1005@2|Bacteria,46SIJ@74201|Verrucomicrobia,37G2P@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
DYD2_k127_3447308_1	351607.Acel_0273	2.048e-181	594.0	COG0243@1|root,COG1034@1|root,COG0243@2|Bacteria,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4ES5W@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM NADH-quinone oxidoreductase, chain G	nuoG	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
DYD2_k127_3447308_2	28042.GU90_05700	1.68e-149	485.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4E01D@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
DYD2_k127_3447308_7	298655.KI912266_gene371	2.898e-48	182.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4ESCP@85013|Frankiales	201174|Actinobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
DYD2_k127_3447308_0	211114.JOEF01000002_gene4187	2.888e-188	602.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4DZ6H@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
DYD2_k127_3447308_8	1380347.JNII01000010_gene2320	5.55e-36	147.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4ESFW@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
DYD2_k127_3447308_5	1380347.JNII01000010_gene2319	9.772e-83	276.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4ERM4@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
DYD2_k127_3447308_9	316067.Geob_0462	1.226e-31	130.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42W9X@68525|delta/epsilon subdivisions,2WSEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA-1	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
DYD2_k127_3447308_3	298654.FraEuI1c_6275	5.904e-143	472.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4ERPF@85013|Frankiales	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
DYD2_k127_3447308_4	469383.Cwoe_5890	7.332e-98	333.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4CR71@84995|Rubrobacteria	84995|Rubrobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DYD2_k127_3447308_6	1380390.JIAT01000009_gene1883	1.631e-56	224.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4CPPP@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DYD2_k127_346389_0	316274.Haur_4476	8.478e-140	460.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2G5VK@200795|Chloroflexi,37589@32061|Chloroflexia	32061|Chloroflexia	E	glutamate synthase, alpha subunit domain protein	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
DYD2_k127_346389_1	469383.Cwoe_4727	1.349e-105	356.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CRSZ@84995|Rubrobacteria	84995|Rubrobacteria	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
DYD2_k127_346389_2	500153.JOEK01000017_gene3282	1.118e-90	312.0	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
DYD2_k127_346389_3	1137268.AZXF01000006_gene1956	4.262e-80	291.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4EGFJ@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_346389_5	1238182.C882_3222	5.514e-09	59.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,2JPU6@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
DYD2_k127_346389_4	1038867.AXAY01000037_gene381	2.41e-21	98.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,3JY1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0093)	MA20_24805	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
DYD2_k127_3488436_4	1123321.KB905815_gene3310	8.022e-12	70.0	COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria	201174|Actinobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0414c	TMP-TENI
DYD2_k127_3488436_5	1125863.JAFN01000001_gene748	1.523e-11	70.0	COG2022@1|root,COG2022@2|Bacteria,1QYPA@1224|Proteobacteria	1224|Proteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
DYD2_k127_3488436_1	497964.CfE428DRAFT_1577	9.277e-103	346.0	COG0502@1|root,COG0502@2|Bacteria,46SFX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin and Thiamin Synthesis associated domain	-	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
DYD2_k127_3488436_0	118005.AWNK01000001_gene1919	5.397e-107	353.0	COG2022@1|root,COG2022@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947	DAO,ThiG
DYD2_k127_3488436_6	1463936.JOJI01000020_gene342	9.946e-05	53.0	2FHY0@1|root,349R0@2|Bacteria,2H0P7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3488436_3	1121430.JMLG01000001_gene2374	1.061e-57	218.0	COG0702@1|root,COG0702@2|Bacteria,1TWZS@1239|Firmicutes,24EGR@186801|Clostridia,266V5@186807|Peptococcaceae	186801|Clostridia	M	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
DYD2_k127_3488436_2	525904.Tter_1683	7.079e-63	229.0	COG0515@1|root,COG3103@1|root,COG0515@2|Bacteria,COG4991@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K07282,ko:K12132,ko:K15539	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,SH3_3,SH3_4
DYD2_k127_3508178_3	742818.HMPREF9451_01575	1.113e-06	59.0	COG4907@1|root,COG4907@2|Bacteria,2HUJ8@201174|Actinobacteria,4CUWT@84998|Coriobacteriia	84998|Coriobacteriia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
DYD2_k127_3508178_1	235985.BBPN01000032_gene230	2.301e-84	284.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,2NE8F@228398|Streptacidiphilus	201174|Actinobacteria	L	RecR protein	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
DYD2_k127_3508178_0	635013.TherJR_0068	2.594e-106	366.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,2602Z@186807|Peptococcaceae	186801|Clostridia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
DYD2_k127_3508178_2	156889.Mmc1_2972	8.421e-08	55.0	COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_9
DYD2_k127_3518774_2	1415780.JPOG01000001_gene2311	3.416e-12	68.0	28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,1RP4W@1236|Gammaproteobacteria,1X5NC@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3518774_1	265729.GS18_0205520	8.774e-15	86.0	COG0584@1|root,COG0584@2|Bacteria,1UGF1@1239|Firmicutes,4H9QE@91061|Bacilli,1ZPVG@1386|Bacillus	91061|Bacilli	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	DUF1080,GDPD
DYD2_k127_3518774_0	913325.N799_12670	5.524e-101	334.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1X5FC@135614|Xanthomonadales	135614|Xanthomonadales	S	Extradiol ring-cleavage dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
DYD2_k127_3521099_1	561175.KB894093_gene3836	1.131e-24	114.0	COG2270@1|root,COG2270@2|Bacteria,2GK5A@201174|Actinobacteria,4EQZ9@85012|Streptosporangiales	201174|Actinobacteria	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_3521099_0	469371.Tbis_3568	3.892e-167	535.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4DYY3@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
DYD2_k127_3521099_2	710696.Intca_3622	1.657e-16	83.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria,4FGKN@85021|Intrasporangiaceae	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
DYD2_k127_3541182_1	1313172.YM304_10540	2.332e-40	154.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4CN5Y@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Ribose/Galactose Isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
DYD2_k127_3541182_3	1123504.JQKD01000051_gene693	2.749e-14	79.0	COG0394@1|root,COG0394@2|Bacteria,1N0DZ@1224|Proteobacteria,2VT1B@28216|Betaproteobacteria,4AF8C@80864|Comamonadaceae	28216|Betaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	epsP	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DYD2_k127_3541182_0	446466.Cfla_1063	6.907e-46	178.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4F0H6@85016|Cellulomonadaceae	201174|Actinobacteria	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
DYD2_k127_3541182_2	525909.Afer_1807	1.903e-24	107.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4CN5W@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Methyltransferase small domain	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
DYD2_k127_3586526_0	926569.ANT_26260	8.412e-61	234.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2G87D@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
DYD2_k127_3613147_0	1048339.KB913029_gene4307	3.619e-180	576.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4ERBS@85013|Frankiales	201174|Actinobacteria	S	peptidase U62, modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
DYD2_k127_3613147_1	471852.Tcur_2275	4.938e-116	391.0	COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria,4EGPS@85012|Streptosporangiales	201174|Actinobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
DYD2_k127_3613147_3	1410668.JNKC01000016_gene993	1.158e-05	48.0	2DES4@1|root,2ZP1M@2|Bacteria,1W3CF@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3613147_2	485913.Krac_5508	1.404e-23	108.0	COG2318@1|root,COG2318@2|Bacteria,2G92D@200795|Chloroflexi	2|Bacteria	S	SPTR D1C1B9 DinB family protein	dinB	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB
DYD2_k127_3616868_4	1240349.ANGC01000062_gene4322	7.73e-09	60.0	COG2208@1|root,COG2208@2|Bacteria,2GNG4@201174|Actinobacteria,4G57Z@85025|Nocardiaceae	201174|Actinobacteria	KT	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
DYD2_k127_3616868_5	1155714.KB891996_gene3632	6.472e-06	55.0	COG1366@1|root,COG1366@2|Bacteria,2II16@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
DYD2_k127_3616868_2	1068980.ARVW01000001_gene999	6.37e-43	173.0	COG2203@1|root,COG2203@2|Bacteria,2GQ2V@201174|Actinobacteria,4E62F@85010|Pseudonocardiales	201174|Actinobacteria	T	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR,GAF_2
DYD2_k127_3616868_1	1128421.JAGA01000002_gene1136	2.546e-51	187.0	COG5646@1|root,COG5646@2|Bacteria,2NQX2@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DYD2_k127_3616868_0	35754.JNYJ01000060_gene2493	1.828e-166	541.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4D8KQ@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
DYD2_k127_3616868_3	595536.ADVE02000001_gene1183	5.625e-18	100.0	COG1404@1|root,COG5549@1|root,COG1404@2|Bacteria,COG5549@2|Bacteria,1MU3S@1224|Proteobacteria,2U4GD@28211|Alphaproteobacteria,370TQ@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
DYD2_k127_3616868_6	1452535.JARD01000006_gene2948	0.0007713	53.0	COG3757@1|root,COG4932@1|root,COG3757@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	DUF1906,Glyco_hydro_92,Neocarzinostat
DYD2_k127_3635600_4	288705.RSal33209_1940	8.018e-45	165.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,1W7I4@1268|Micrococcaceae	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
DYD2_k127_3635600_0	1313172.YM304_29160	4.661e-116	379.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4CP57@84992|Acidimicrobiia	201174|Actinobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028,ko:K09972,ko:K10041	ko02010,map02010	M00228,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
DYD2_k127_3635600_2	383372.Rcas_1456	2.932e-78	287.0	COG0765@1|root,COG0765@2|Bacteria,2G845@200795|Chloroflexi,376Y4@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
DYD2_k127_3635600_3	357808.RoseRS_4004	3.41e-77	273.0	COG4597@1|root,COG4597@2|Bacteria,2G7PM@200795|Chloroflexi,376AX@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
DYD2_k127_3635600_1	1521187.JPIM01000057_gene2586	3.753e-107	359.0	COG0834@1|root,COG0834@2|Bacteria,2G7RH@200795|Chloroflexi,376Y9@32061|Chloroflexia	32061|Chloroflexia	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
DYD2_k127_365695_1	1142394.PSMK_28980	1.883e-28	117.0	COG0024@1|root,COG0024@2|Bacteria,2IXPX@203682|Planctomycetes	203682|Planctomycetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DYD2_k127_365695_4	1215915.BN193_03000	6.324e-13	77.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,4HJDZ@91061|Bacilli	91061|Bacilli	S	Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane	yvaZ	GO:0008150,GO:0009636,GO:0042221,GO:0050896	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
DYD2_k127_365695_2	867903.ThesuDRAFT_01152	4.88e-25	106.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,24NEC@186801|Clostridia,3WDRA@538999|Clostridiales incertae sedis	186801|Clostridia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DYD2_k127_365695_3	1173263.Syn7502_03353	2.413e-20	100.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
DYD2_k127_365695_0	670487.Ocepr_1481	2.419e-70	243.0	2DB7V@1|root,2Z7NX@2|Bacteria,1WM7S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3668753_2	269800.Tfu_2476	2.441e-52	189.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4EJ2F@85012|Streptosporangiales	201174|Actinobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
DYD2_k127_3668753_3	697281.Mahau_0659	2.371e-46	183.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,42FSF@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Peptidase M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
DYD2_k127_3668753_4	525909.Afer_1760	3.376e-46	179.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CN4Q@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
DYD2_k127_3668753_0	570268.ANBB01000035_gene2270	2.428e-99	328.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4EG9N@85012|Streptosporangiales	201174|Actinobacteria	D	ATPases associated with a variety of cellular activities	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
DYD2_k127_3668753_1	429009.Adeg_0470	6.718e-80	276.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,42ET8@68295|Thermoanaerobacterales	186801|Clostridia	G	Transketolase, central region	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
DYD2_k127_3668753_5	643648.Slip_1874	1.075e-20	93.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42K2N@68298|Syntrophomonadaceae	186801|Clostridia	G	XFP N-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
DYD2_k127_3674524_0	326424.FRAAL4607	2.933e-285	889.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4ERJA@85013|Frankiales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
DYD2_k127_3674524_1	316274.Haur_2846	6.002e-108	359.0	COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,37738@32061|Chloroflexia	200795|Chloroflexi	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
DYD2_k127_3674524_2	1229780.BN381_130287	1.588e-90	306.0	COG1121@1|root,COG1121@2|Bacteria,2GN95@201174|Actinobacteria,3UXDF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.35	ko:K09820,ko:K11710,ko:K19973	ko02010,map02010	M00243,M00319,M00792	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.15	-	-	ABC_tran
DYD2_k127_3674524_3	316274.Haur_2844	3.059e-80	277.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,376AB@32061|Chloroflexia	200795|Chloroflexi	P	ABC-3 protein	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
DYD2_k127_3674524_4	66875.JODY01000027_gene5371	3.257e-36	145.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
DYD2_k127_3674524_5	525904.Tter_2687	9.045e-34	132.0	COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DYD2_k127_3683228_5	35754.JNYJ01000037_gene4630	1.38e-18	94.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4DAIZ@85008|Micromonosporales	201174|Actinobacteria	G	Starch synthase catalytic domain	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3683228_0	1121272.KB903257_gene5483	1.498e-97	325.0	2EWQK@1|root,33Q2D@2|Bacteria,2IJ4T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3683228_1	1120934.KB894408_gene4901	1.584e-93	325.0	COG1543@1|root,COG1543@2|Bacteria,2GKTI@201174|Actinobacteria,4DZYG@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
DYD2_k127_3683228_3	446462.Amir_6056	9.429e-59	214.0	COG2227@1|root,COG2227@2|Bacteria,2GMMX@201174|Actinobacteria,4DXPQ@85010|Pseudonocardiales	201174|Actinobacteria	H	PFAM Methyltransferase domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
DYD2_k127_3683228_2	326424.FRAAL6833	1.047e-80	284.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4ESHI@85013|Frankiales	201174|Actinobacteria	E	PFAM extracellular solute-binding protein family 1	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
DYD2_k127_3683228_4	1396141.BATP01000060_gene4701	3.701e-31	140.0	COG1541@1|root,COG1541@2|Bacteria,46UTU@74201|Verrucomicrobia,2ITXN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
DYD2_k127_3712729_3	1246995.AFR_38325	4.087e-27	111.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4D94T@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
DYD2_k127_3712729_2	1283283.ATXA01000002_gene2711	9.081e-40	162.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria,4ERD1@85013|Frankiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
DYD2_k127_3712729_0	1313172.YM304_09040	5.331e-126	411.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CMUQ@84992|Acidimicrobiia	201174|Actinobacteria	D	Cell division protein FtsA	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
DYD2_k127_3712729_1	543632.JOJL01000020_gene554	1.998e-45	183.0	COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria,4DAEM@85008|Micromonosporales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	mycP	-	-	ko:K14645,ko:K14743	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
DYD2_k127_3712729_4	1304865.JAGF01000001_gene2105	3.375e-05	50.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4F128@85016|Cellulomonadaceae	201174|Actinobacteria	T	Lon protease (S16) C-terminal proteolytic domain	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
DYD2_k127_3715814_1	1121430.JMLG01000012_gene1976	4.557e-60	220.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,260M6@186807|Peptococcaceae	186801|Clostridia	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
DYD2_k127_3715814_3	656024.FsymDg_4529	7.601e-25	109.0	2CQNK@1|root,32SMG@2|Bacteria,2IIJ7@201174|Actinobacteria,4ET55@85013|Frankiales	201174|Actinobacteria	S	Family of unknown function (DUF5318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5318
DYD2_k127_3715814_2	1123321.KB905820_gene5550	2.759e-32	132.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
DYD2_k127_3715814_0	1120934.KB894421_gene2583	1.244e-115	379.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4DYY3@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
DYD2_k127_3726361_3	909613.UO65_5333	2.367e-28	117.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4E15A@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_3726361_2	1288079.AUKN01000019_gene2729	2.589e-95	330.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
DYD2_k127_3726361_4	222534.KB893670_gene3690	0.000124	52.0	2C4RB@1|root,2ZVRN@2|Bacteria,2HAZK@201174|Actinobacteria,4EWZ7@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3726361_1	298653.Franean1_0915	2.258e-97	324.0	COG1192@1|root,COG1192@2|Bacteria,2GNEQ@201174|Actinobacteria,4EUFG@85013|Frankiales	201174|Actinobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
DYD2_k127_3726361_0	234267.Acid_3616	5.419e-164	524.0	COG0436@1|root,COG0436@2|Bacteria,3Y2TF@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_3738102_0	357808.RoseRS_0010	9.206e-53	205.0	COG0823@1|root,COG0823@2|Bacteria,2G8T5@200795|Chloroflexi,376FH@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
DYD2_k127_3738102_2	1380763.BG53_07330	1.781e-24	107.0	COG5628@1|root,COG5628@2|Bacteria,1VAGU@1239|Firmicutes,4HHK0@91061|Bacilli,26QQ8@186822|Paenibacillaceae	91061|Bacilli	S	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_3738102_3	512565.AMIS_31290	2.002e-18	95.0	COG0662@1|root,COG0662@2|Bacteria,2IEY0@201174|Actinobacteria,4DDRC@85008|Micromonosporales	201174|Actinobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
DYD2_k127_3738102_1	1089455.MOPEL_096_00660	3.812e-50	194.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4F6PP@85018|Dermatophilaceae	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
DYD2_k127_3761212_1	42256.RradSPS_0696	4.247e-90	299.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CP9K@84995|Rubrobacteria	84995|Rubrobacteria	F	IMP dehydrogenase GMP reductase	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
DYD2_k127_3761212_2	1048983.EL17_14975	2.761e-15	88.0	COG1913@1|root,COG1913@2|Bacteria,4NJFJ@976|Bacteroidetes,47Q85@768503|Cytophagia	976|Bacteroidetes	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
DYD2_k127_3761212_0	710111.FraQA3DRAFT_3806	5.539e-117	383.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4ERBR@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
DYD2_k127_3769792_1	298653.Franean1_2161	5.435e-65	233.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4ERX0@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
DYD2_k127_3769792_2	298655.KI912266_gene3604	4.184e-11	74.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_3769792_0	338966.Ppro_3385	4.7e-138	462.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
DYD2_k127_3769792_3	757424.Hsero_1991	7.137e-05	51.0	COG3206@1|root,COG3206@2|Bacteria,1RK0N@1224|Proteobacteria,2VHPS@28216|Betaproteobacteria,47233@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Chain length determinant protein	epsF	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
DYD2_k127_3780697_1	1172188.KB911821_gene1249	2.195e-69	252.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4FEQ2@85021|Intrasporangiaceae	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
DYD2_k127_3780697_0	1123023.JIAI01000002_gene5226	2.891e-154	498.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4DXJ9@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
DYD2_k127_3780697_3	1122611.KB903955_gene5461	4.848e-06	55.0	COG2172@1|root,COG2172@2|Bacteria,2IIBX@201174|Actinobacteria,4EQAS@85012|Streptosporangiales	201174|Actinobacteria	T	sigma factor antagonist activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
DYD2_k127_3780697_2	390989.JOEG01000003_gene4476	7.34e-44	167.0	COG1295@1|root,COG1295@2|Bacteria,2HSM4@201174|Actinobacteria,4DFKR@85008|Micromonosporales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
DYD2_k127_3798700_6	351607.Acel_1339	2.142e-54	195.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4ESW6@85013|Frankiales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
DYD2_k127_3798700_0	1313172.YM304_19960	1.292e-243	773.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CMVH@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
DYD2_k127_3798700_7	292459.STH2430	1.22e-44	167.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
DYD2_k127_3798700_5	235985.BBPN01000027_gene1581	1.304e-54	201.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,2NEWS@228398|Streptacidiphilus	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
DYD2_k127_3798700_4	349161.Dred_0756	2.543e-103	357.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,26071@186807|Peptococcaceae	186801|Clostridia	J	tRNA synthetase class II core domain (G, H, P, S and T)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
DYD2_k127_3798700_2	1121468.AUBR01000003_gene626	8.419e-194	621.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,42EM9@68295|Thermoanaerobacterales	186801|Clostridia	J	L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
DYD2_k127_3798700_3	1120949.KB903350_gene8254	1.493e-116	392.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4D9FJ@85008|Micromonosporales	201174|Actinobacteria	L	ATPase related to the helicase subunit of the Holliday junction resolvase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
DYD2_k127_3798700_1	1273538.G159_10350	5.759e-203	660.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,26DYV@186818|Planococcaceae	91061|Bacilli	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DYD2_k127_3809391_1	1463864.JOGO01000027_gene5698	8.903e-109	369.0	COG0204@1|root,COG0204@2|Bacteria,2GJKH@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
DYD2_k127_3809391_0	656024.FsymDg_4059	3.055e-119	395.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4ERGC@85013|Frankiales	201174|Actinobacteria	M	PFAM NAD-dependent epimerase dehydratase	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0501	Epimerase
DYD2_k127_3809391_2	222534.KB893739_gene1430	9.054e-72	251.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria	201174|Actinobacteria	S	transferase activity, transferring alkyl or aryl (other than methyl) groups	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
DYD2_k127_3809391_4	1027371.GOALK_050_02500	2.456e-10	66.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4GESB@85026|Gordoniaceae	201174|Actinobacteria	K	Helix-turn-helix domain	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DYD2_k127_3809391_3	1463881.KL591013_gene1216	9.643e-38	148.0	2EBHZ@1|root,335IE@2|Bacteria,2GNMR@201174|Actinobacteria	201174|Actinobacteria	S	Phosphatase	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	-	-	-	-	-	-	-	-	-	-	Phosphatase
DYD2_k127_381528_1	1122609.AUGT01000005_gene1621	3.386e-94	323.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4DNUG@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
DYD2_k127_381528_0	1120950.KB892766_gene5096	1.833e-120	399.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4DNZK@85009|Propionibacteriales	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
DYD2_k127_381528_2	1068978.AMETH_1778	7.642e-31	124.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4E5NQ@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
DYD2_k127_381528_3	68260.JOAY01000004_gene4726	2.291e-28	121.0	COG1595@1|root,COG1595@2|Bacteria,2IC8V@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_3823732_0	28444.JODQ01000014_gene6775	2.522e-170	550.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4EGGE@85012|Streptosporangiales	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
DYD2_k127_3846507_0	1048339.KB913029_gene2651	4.032e-15	88.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DYD2_k127_3846507_1	298655.KI912266_gene6040	0.0002344	52.0	COG0411@1|root,COG0559@1|root,COG4177@1|root,COG0411@2|Bacteria,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
DYD2_k127_3883429_4	1128421.JAGA01000002_gene1308	4.09e-36	142.0	COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria	2|Bacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DYD2_k127_3883429_8	1380347.JNII01000008_gene4383	0.0003037	48.0	COG3847@1|root,COG3847@2|Bacteria,2GX2Y@201174|Actinobacteria	201174|Actinobacteria	U	PFAM Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
DYD2_k127_3883429_6	367299.JOEE01000003_gene2952	1.514e-07	56.0	COG3847@1|root,COG3847@2|Bacteria,2GX2Y@201174|Actinobacteria,4FI4I@85021|Intrasporangiaceae	201174|Actinobacteria	U	Flp/Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
DYD2_k127_3883429_7	1121946.AUAX01000006_gene3408	6.756e-06	54.0	COG4961@1|root,COG4961@2|Bacteria,2HWWQ@201174|Actinobacteria,4DKKI@85008|Micromonosporales	201174|Actinobacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
DYD2_k127_3883429_5	1077972.ARGLB_085_03380	3.279e-20	100.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria,1WBDP@1268|Micrococcaceae	201174|Actinobacteria	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
DYD2_k127_3883429_1	351607.Acel_0975	8.433e-74	262.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,4EVMD@85013|Frankiales	201174|Actinobacteria	D	Evidence 2b Function of strongly homologous gene	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
DYD2_k127_3883429_0	110319.CF8_2739	7.354e-186	591.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4DPMF@85009|Propionibacteriales	201174|Actinobacteria	U	Type II/IV secretion system protein	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DYD2_k127_3883429_3	1306174.JODP01000009_gene6554	1.263e-59	222.0	COG4965@1|root,COG4965@2|Bacteria,2H577@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
DYD2_k127_3883429_2	1298863.AUEP01000018_gene3825	1.431e-72	256.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4DR34@85009|Propionibacteriales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
DYD2_k127_3890906_4	234267.Acid_4526	0.0001191	50.0	COG0577@1|root,COG0577@2|Bacteria,3Y36E@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
DYD2_k127_3890906_3	485913.Krac_5098	2.033e-29	121.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
DYD2_k127_3890906_1	28444.JODQ01000008_gene1022	3.864e-40	151.0	COG0640@1|root,COG0640@2|Bacteria,2IM1K@201174|Actinobacteria,4EJG2@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DYD2_k127_3890906_2	1123024.AUII01000005_gene2194	1.91e-31	135.0	COG3832@1|root,COG3832@2|Bacteria,2I8ND@201174|Actinobacteria,4E380@85010|Pseudonocardiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
DYD2_k127_3890906_0	1123321.KB905813_gene951	3.639e-68	250.0	COG0654@1|root,COG0654@2|Bacteria,2I901@201174|Actinobacteria	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Trp_halogenase
DYD2_k127_3923541_0	1128421.JAGA01000004_gene2680	1.144e-129	429.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria	2|Bacteria	Q	phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,Hydrolase_3
DYD2_k127_3923541_1	99598.Cal7507_6086	1.082e-71	246.0	COG3548@1|root,COG3548@2|Bacteria,1GKP7@1117|Cyanobacteria,1HRK3@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
DYD2_k127_3923541_2	471852.Tcur_3942	3.157e-17	85.0	COG0745@1|root,COG0745@2|Bacteria,2I2Z1@201174|Actinobacteria,4EJHI@85012|Streptosporangiales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_393158_3	1463845.JOIG01000002_gene2365	1.184e-41	158.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria	201174|Actinobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
DYD2_k127_393158_0	264732.Moth_0915	6.804e-88	302.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
DYD2_k127_393158_2	1232443.BAIA02000106_gene3180	3.394e-56	207.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,268XI@186813|unclassified Clostridiales	186801|Clostridia	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
DYD2_k127_393158_1	266940.Krad_2984	1.392e-67	246.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
DYD2_k127_393158_4	1206730.BAGA01000091_gene401	1.57e-41	161.0	COG0242@1|root,COG0242@2|Bacteria,2INYK@201174|Actinobacteria,4FU5X@85025|Nocardiaceae	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
DYD2_k127_393158_5	1048339.KB913029_gene3997	1.104e-27	125.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4ERHY@85013|Frankiales	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
DYD2_k127_3958945_0	644282.Deba_1628	2.762e-148	490.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DYD2_k127_3958945_1	1123024.AUII01000004_gene1602	9.902e-84	298.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4DXM8@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferases group 1	pimB	GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3958945_2	67352.JODS01000002_gene1294	1.088e-43	166.0	COG0501@1|root,COG0501@2|Bacteria,2GRBS@201174|Actinobacteria	201174|Actinobacteria	O	PFAM peptidase M48 Ste24p	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
DYD2_k127_3962044_1	2045.KR76_16195	9.374e-24	110.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4DN9G@85009|Propionibacteriales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
DYD2_k127_3962044_0	1449353.JQMQ01000005_gene2960	1.001e-56	211.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,2NF0X@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DYD2_k127_3962044_2	574087.Acear_0068	1.618e-15	82.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24I20@186801|Clostridia	186801|Clostridia	M	PFAM Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
DYD2_k127_3962044_3	33178.CADATEAP00005809	4.574e-07	60.0	COG0664@1|root,KOG1113@2759|Eukaryota,38GS1@33154|Opisthokonta,3NU9Z@4751|Fungi,3QKI5@4890|Ascomycota,20B0K@147545|Eurotiomycetes,3S7XK@5042|Eurotiales	4751|Fungi	T	cAMP-dependent protein kinase regulatory subunit	PKAR	GO:0000003,GO:0000166,GO:0000228,GO:0000785,GO:0000790,GO:0001932,GO:0001933,GO:0002831,GO:0002832,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005886,GO:0005952,GO:0006469,GO:0006950,GO:0006979,GO:0007154,GO:0008104,GO:0008150,GO:0008277,GO:0008603,GO:0009266,GO:0009267,GO:0009405,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009653,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010563,GO:0010570,GO:0010605,GO:0010639,GO:0010646,GO:0010648,GO:0016020,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0019954,GO:0022603,GO:0023051,GO:0023057,GO:0030154,GO:0030234,GO:0030291,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0030551,GO:0030552,GO:0030554,GO:0031279,GO:0031281,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032268,GO:0032269,GO:0032386,GO:0032388,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032880,GO:0032991,GO:0033036,GO:0033043,GO:0033157,GO:0033554,GO:0033673,GO:0034305,GO:0034599,GO:0034605,GO:0034613,GO:0036094,GO:0036170,GO:0036180,GO:0040007,GO:0040008,GO:0042173,GO:0042221,GO:0042325,GO:0042326,GO:0042594,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0043934,GO:0043936,GO:0043937,GO:0043938,GO:0043943,GO:0043945,GO:0043949,GO:0043951,GO:0044092,GO:0044093,GO:0044182,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045595,GO:0045597,GO:0045744,GO:0045761,GO:0045762,GO:0045786,GO:0045859,GO:0045881,GO:0045926,GO:0045936,GO:0046578,GO:0046580,GO:0046822,GO:0046824,GO:0046825,GO:0046827,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051056,GO:0051058,GO:0051094,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051246,GO:0051248,GO:0051338,GO:0051339,GO:0051348,GO:0051349,GO:0051445,GO:0051447,GO:0051641,GO:0051704,GO:0051716,GO:0051726,GO:0051783,GO:0051784,GO:0060255,GO:0060258,GO:0060341,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070727,GO:0070887,GO:0071496,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0080134,GO:0090087,GO:0090316,GO:0097159,GO:0097271,GO:0097367,GO:0098772,GO:0106070,GO:0106072,GO:0110033,GO:0110034,GO:1900428,GO:1900429,GO:1900434,GO:1900435,GO:1900443,GO:1900444,GO:1901265,GO:1901363,GO:1902531,GO:1902532,GO:1902659,GO:1902660,GO:1903664,GO:1903666,GO:1903827,GO:1903829,GO:1904951,GO:2000241,GO:2000242,GO:2000479,GO:2000480	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	RIIa,cNMP_binding
DYD2_k127_3963693_2	768671.ThimaDRAFT_2715	1.446e-76	263.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
DYD2_k127_3963693_0	1229780.BN381_290121	6.233e-118	395.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,3UW6N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DYD2_k127_3963693_3	596151.DesfrDRAFT_3402	3.212e-22	100.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42PHH@68525|delta/epsilon subdivisions,2WV9C@28221|Deltaproteobacteria,2M8TF@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS,PAS_4,Response_reg
DYD2_k127_3963693_1	351607.Acel_1259	9.439e-90	304.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4ERRI@85013|Frankiales	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DYD2_k127_3986187_3	397278.JOJN01000006_gene976	2.48e-10	61.0	COG1024@1|root,COG1024@2|Bacteria,2I7QX@201174|Actinobacteria,4DRJV@85009|Propionibacteriales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
DYD2_k127_3986187_2	1079986.JH164855_gene513	3.008e-11	74.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,MDMPI_N,Pentapeptide
DYD2_k127_3986187_1	1226994.AMZB01000128_gene4302	2.843e-15	82.0	COG2050@1|root,COG2050@2|Bacteria,1MYE0@1224|Proteobacteria,1S2CT@1236|Gammaproteobacteria,1YGE5@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	Domain of unknown function (DUF4442)	entH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
DYD2_k127_3986187_0	465541.ATCJ01000005_gene5238	1.285e-42	163.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria	201174|Actinobacteria	S	metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
DYD2_k127_3987940_0	33876.JNXY01000004_gene1782	1.741e-83	286.0	COG0175@1|root,COG0175@2|Bacteria,2IJTF@201174|Actinobacteria,4DJ6U@85008|Micromonosporales	201174|Actinobacteria	EH	sulfate reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3991983_1	1415166.NONO_c38250	0.0003415	46.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4FW27@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249	ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_3991983_0	795797.C497_02257	2.201e-47	192.0	COG2936@1|root,arCOG07590@2157|Archaea	2157|Archaea	S	acyl esterases	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_4005877_2	500153.JOEK01000007_gene4372	7.478e-20	102.0	COG3572@1|root,COG3572@2|Bacteria,2GJPI@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine	egtA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
DYD2_k127_4005877_1	1037409.BJ6T_56240	4.155e-135	443.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,3JTK8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc,Hydrolase_4,Trans_reg_C
DYD2_k127_4005877_0	1122622.ATWJ01000001_gene2549	2.292e-147	485.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4FF74@85021|Intrasporangiaceae	201174|Actinobacteria	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DYD2_k127_4005877_3	1894.JOER01000022_gene3932	3.182e-09	58.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria	201174|Actinobacteria	D	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
DYD2_k127_4032286_2	562970.Btus_0141	1.057e-26	110.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,4HAK4@91061|Bacilli,278Y0@186823|Alicyclobacillaceae	91061|Bacilli	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DYD2_k127_4032286_1	1193181.BN10_840001	1.157e-44	172.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4FEG8@85021|Intrasporangiaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
DYD2_k127_4032286_0	397278.JOJN01000002_gene264	1.331e-45	168.0	COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4DQS8@85009|Propionibacteriales	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
DYD2_k127_4032286_3	204669.Acid345_4088	0.0002154	52.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,CBM_35,DUF1080,PKD
DYD2_k127_4034577_0	471852.Tcur_3039	2.565e-132	431.0	COG2876@1|root,COG2876@2|Bacteria,2I3UA@201174|Actinobacteria,4EI1I@85012|Streptosporangiales	201174|Actinobacteria	E	NeuB family	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
DYD2_k127_4034577_1	1125863.JAFN01000001_gene1993	3.21e-51	188.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
DYD2_k127_4036652_0	656024.FsymDg_0011	1.59e-274	867.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4ERIW@85013|Frankiales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3
DYD2_k127_4036652_1	1081644.IMCC13023_02600	2.135e-228	727.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4FMXF@85023|Microbacteriaceae	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DYD2_k127_4036652_8	414996.IL38_01650	2.041e-13	78.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4097V@622450|Actinopolysporales	201174|Actinobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
DYD2_k127_4036652_4	590998.Celf_0004	7.259e-70	250.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4F1WA@85016|Cellulomonadaceae	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
DYD2_k127_4036652_3	1313172.YM304_00020	7.929e-80	279.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CN18@84992|Acidimicrobiia	84992|Acidimicrobiia	L	DNA polymerase III beta subunit	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
DYD2_k127_4036652_2	298654.FraEuI1c_0001	2.786e-142	471.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4ES24@85013|Frankiales	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
DYD2_k127_4036652_9	521096.Tpau_4243	1.38e-11	67.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
DYD2_k127_4036652_10	1122609.AUGT01000019_gene335	1.047e-09	66.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
DYD2_k127_4036652_6	352165.HMPREF7215_2676	7.206e-19	89.0	COG0759@1|root,COG0759@2|Bacteria,3TBI4@508458|Synergistetes	508458|Synergistetes	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
DYD2_k127_4036652_7	1321781.HMPREF1985_00188	2.239e-17	95.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,4H3YP@909932|Negativicutes	909932|Negativicutes	U	Membrane protein insertase, YidC Oxa1 family	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
DYD2_k127_4036652_5	408672.NBCG_00559	5.55e-32	132.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4DQRW@85009|Propionibacteriales	201174|Actinobacteria	S	Putative single-stranded nucleic acids-binding domain	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
DYD2_k127_4041269_0	1121468.AUBR01000017_gene2394	0.0	1059.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42EPB@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
DYD2_k127_4041269_9	316274.Haur_3703	1.083e-27	124.0	COG2802@1|root,COG2802@2|Bacteria,2G76N@200795|Chloroflexi,375N5@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase S16 lon domain protein	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
DYD2_k127_4041269_2	445975.COLSTE_00525	2.021e-103	351.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4CURH@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
DYD2_k127_4041269_4	1313172.YM304_22610	9.372e-80	284.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4CMYU@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_4041269_6	351607.Acel_1060	8.185e-63	225.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4ESDH@85013|Frankiales	201174|Actinobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
DYD2_k127_4041269_5	1210046.B277_05421	1.154e-70	250.0	COG0106@1|root,COG0118@1|root,COG0106@2|Bacteria,COG0118@2|Bacteria,2GJ4V@201174|Actinobacteria,4FEZV@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5- (5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DYD2_k127_4041269_3	477974.Daud_1622	1.658e-97	324.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,260VM@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05755	His_biosynth
DYD2_k127_4041269_8	1128421.JAGA01000002_gene55	1.112e-32	143.0	COG2227@1|root,COG2227@2|Bacteria,2NRDG@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
DYD2_k127_4041269_7	445975.COLSTE_00519	1.901e-48	178.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4CW3C@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
DYD2_k127_4041269_1	1120934.KB894423_gene2681	1.141e-148	484.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4DYDE@85010|Pseudonocardiales	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
DYD2_k127_4070655_3	1089551.KE386572_gene4570	1.022e-37	157.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U0KM@28211|Alphaproteobacteria,4BSBD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DYD2_k127_4070655_6	591167.Sfla_3110	4.542e-24	119.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria	201174|Actinobacteria	P	Copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
DYD2_k127_4070655_7	1382356.JQMP01000003_gene1492	3.275e-22	105.0	arCOG08811@1|root,32UTS@2|Bacteria,2G8VM@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4070655_1	1394178.AWOO02000022_gene7188	1.406e-102	352.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4EFFI@85012|Streptosporangiales	201174|Actinobacteria	S	Reductase C-terminal	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
DYD2_k127_4070655_2	1132442.KB889752_gene2637	2.628e-39	151.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,1ZFQ8@1386|Bacillus	91061|Bacilli	C	COG0822 NifU homolog involved in Fe-S cluster formation	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
DYD2_k127_4070655_4	1380356.JNIK01000006_gene1535	1.624e-37	152.0	COG0705@1|root,COG3063@1|root,COG0705@2|Bacteria,COG3063@2|Bacteria,2GJYG@201174|Actinobacteria,4ESUX@85013|Frankiales	201174|Actinobacteria	NU	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
DYD2_k127_4070655_5	526225.Gobs_4536	3.42e-25	116.0	COG0789@1|root,COG0789@2|Bacteria,2INKP@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind
DYD2_k127_4070655_0	263358.VAB18032_22370	2.682e-167	543.0	COG4447@1|root,COG4447@2|Bacteria,2I4PF@201174|Actinobacteria,4DC47@85008|Micromonosporales	201174|Actinobacteria	E	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
DYD2_k127_4073308_0	1229780.BN381_130019	4.66e-94	319.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,3UWF7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DYD2_k127_4073308_1	316278.SynRCC307_1240	1.817e-77	267.0	COG0047@1|root,COG0047@2|Bacteria,1G18Q@1117|Cyanobacteria,1GYZF@1129|Synechococcus	1117|Cyanobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
DYD2_k127_4073308_3	1117108.PAALTS15_03942	5.738e-18	87.0	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,26Z31@186822|Paenibacillaceae	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
DYD2_k127_4073308_2	882.DVU_0795	3.7e-33	129.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2M95X@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
DYD2_k127_4098582_7	1408433.JHXV01000006_gene2765	2.616e-10	68.0	COG2272@1|root,COG2272@2|Bacteria,4PI06@976|Bacteroidetes,1IG13@117743|Flavobacteriia,2PB7F@246874|Cryomorphaceae	976|Bacteroidetes	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	COesterase
DYD2_k127_4098582_0	1033802.SSPSH_003175	3.994e-97	341.0	COG3055@1|root,COG3055@2|Bacteria,1QE0Q@1224|Proteobacteria,1RYPR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1929,Kelch_4
DYD2_k127_4098582_3	1122138.AQUZ01000014_gene7003	3.541e-44	178.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4DN2Y@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
DYD2_k127_4098582_1	1282361.ABAC402_17145	8.659e-56	214.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,P_proprotein,Peptidase_S8
DYD2_k127_4098582_6	1211815.CBYP010000036_gene2245	1.928e-10	68.0	COG2050@1|root,COG2050@2|Bacteria,2IR9T@201174|Actinobacteria	201174|Actinobacteria	Q	phenylacetic acid degradation-related	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_4098582_2	266940.Krad_1610	1.046e-44	182.0	COG2199@1|root,COG3706@2|Bacteria,2IHK9@201174|Actinobacteria	201174|Actinobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
DYD2_k127_4110650_2	1121430.JMLG01000006_gene1724	3.452e-95	327.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,26066@186807|Peptococcaceae	186801|Clostridia	KLT	PFAM Protein kinase domain	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DYD2_k127_4110650_1	1095772.CAHH01000015_gene1046	8.329e-98	337.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria	201174|Actinobacteria	M	penicillin-binding protein	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
DYD2_k127_4110650_0	1229780.BN381_70018	2.859e-102	356.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,3UWBG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Cell cycle protein	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
DYD2_k127_4110650_6	1034345.CAEM01000002_gene1191	3.626e-60	223.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CUGE@84998|Coriobacteriia	84998|Coriobacteriia	T	phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	BofC_C,PP2C,PP2C_2
DYD2_k127_4110650_9	469371.Tbis_0050	7.727e-33	132.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4E2PP@85010|Pseudonocardiales	201174|Actinobacteria	T	(FHA) domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
DYD2_k127_4110650_7	1229780.BN381_70015	3.62e-41	160.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,3UWPZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
DYD2_k127_4110650_4	675635.Psed_6017	1.731e-74	265.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4E1ST@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
DYD2_k127_4110650_11	743719.PaelaDRAFT_0809	3.131e-25	112.0	COG0494@1|root,COG0494@2|Bacteria,1UMYB@1239|Firmicutes,4IU37@91061|Bacilli,26XP1@186822|Paenibacillaceae	91061|Bacilli	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_4110650_12	1137271.AZUM01000007_gene3261	2.194e-20	102.0	COG2227@1|root,COG2227@2|Bacteria,2GMMX@201174|Actinobacteria,4DXPQ@85010|Pseudonocardiales	201174|Actinobacteria	H	PFAM Methyltransferase domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
DYD2_k127_4110650_5	634956.Geoth_2346	7.159e-73	262.0	COG1960@1|root,COG1960@2|Bacteria,1TR1Y@1239|Firmicutes,4HC1N@91061|Bacilli,1WFNZ@129337|Geobacillus	91061|Bacilli	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_4110650_10	1146883.BLASA_3891	2.66e-25	117.0	COG2852@1|root,COG2852@2|Bacteria	2|Bacteria	L	Protein conserved in bacteria	ycjD	-	-	-	-	-	-	-	-	-	-	-	DUF559
DYD2_k127_4110650_8	1382356.JQMP01000003_gene1673	7.945e-39	158.0	COG2141@1|root,COG2141@2|Bacteria,2G869@200795|Chloroflexi,27XFF@189775|Thermomicrobia	189775|Thermomicrobia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_4110650_3	653045.Strvi_4998	9.877e-88	306.0	COG1063@1|root,COG1063@2|Bacteria,2GNFX@201174|Actinobacteria	201174|Actinobacteria	E	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
DYD2_k127_4124060_3	525904.Tter_2859	6.34e-102	366.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2NQCZ@2323|unclassified Bacteria	2|Bacteria	K	NB-ARC domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,HTH_31,NB-ARC,Pkinase,TPR_10,TPR_12,Trans_reg_C
DYD2_k127_4124060_7	710687.KI912270_gene713	2.304e-59	212.0	COG1716@1|root,COG1716@2|Bacteria,2HPF7@201174|Actinobacteria,2351W@1762|Mycobacteriaceae	201174|Actinobacteria	T	Fha domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,FHA
DYD2_k127_4124060_2	1313172.YM304_22760	1.031e-102	345.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria	201174|Actinobacteria	P	membrane protein terC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
DYD2_k127_4124060_5	926569.ANT_27550	4.248e-66	235.0	COG5032@1|root,COG5032@2|Bacteria,2G6FZ@200795|Chloroflexi	200795|Chloroflexi	BDLTU	phosphatidylinositol kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	PI3_PI4_kinase
DYD2_k127_4124060_11	926550.CLDAP_03430	5.858e-26	118.0	298YA@1|root,2ZW25@2|Bacteria,2G6UQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
DYD2_k127_4124060_8	765420.OSCT_0512	3.463e-56	203.0	COG0406@1|root,COG0406@2|Bacteria,2G73Q@200795|Chloroflexi,37737@32061|Chloroflexia	32061|Chloroflexia	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
DYD2_k127_4124060_0	562970.Btus_0347	2.436e-289	897.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,4HC0P@91061|Bacilli,278VK@186823|Alicyclobacillaceae	91061|Bacilli	H	ThiC-associated domain	thiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU08790	ThiC-associated,ThiC_Rad_SAM
DYD2_k127_4124060_4	530564.Psta_0358	1.169e-84	296.0	COG4398@1|root,COG4398@2|Bacteria,2IXYT@203682|Planctomycetes	203682|Planctomycetes	S	PFAM FIST C domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
DYD2_k127_4124060_1	931627.MycrhDRAFT_6458	1.5e-109	360.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,236CB@1762|Mycobacteriaceae	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_4124060_10	1206101.AZXC01000021_gene2176	3.621e-32	142.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_4124060_9	1394178.AWOO02000011_gene3932	3.712e-33	139.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4EIK2@85012|Streptosporangiales	201174|Actinobacteria	M	Sortase family	srtB	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
DYD2_k127_4124060_6	525909.Afer_1783	8.21e-61	216.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4CN01@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
DYD2_k127_4124060_13	40571.JOEA01000009_gene3300	5.581e-05	52.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,4E5AT@85010|Pseudonocardiales	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
DYD2_k127_4124060_12	1305732.JAGG01000001_gene987	3.834e-05	49.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4FNQ0@85023|Microbacteriaceae	201174|Actinobacteria	CO	Redoxin	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
DYD2_k127_4125687_4	1122182.KB903825_gene394	3.929e-08	59.0	COG2304@1|root,COG4257@1|root,COG2304@2|Bacteria,COG4257@2|Bacteria,2IDJM@201174|Actinobacteria,4DEGK@85008|Micromonosporales	201174|Actinobacteria	V	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HYR,VWA
DYD2_k127_4125687_1	997346.HMPREF9374_2869	6.336e-90	313.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,27B7R@186824|Thermoactinomycetaceae	91061|Bacilli	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DYD2_k127_4125687_2	1125863.JAFN01000001_gene3315	5.749e-61	217.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
DYD2_k127_4125687_0	222534.KB893739_gene1323	8.063e-151	488.0	COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4ERNA@85013|Frankiales	201174|Actinobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
DYD2_k127_4125687_3	479432.Sros_1105	4.65e-36	139.0	COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4EIUJ@85012|Streptosporangiales	201174|Actinobacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
DYD2_k127_4138709_1	521011.Mpal_1389	4.85e-33	142.0	COG3391@1|root,arCOG02545@1|root,arCOG02545@2157|Archaea,arCOG03563@2157|Archaea	2157|Archaea	P	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,NHL,NosD,PKD
DYD2_k127_4138709_0	585531.HMPREF0063_11828	5.213e-39	169.0	2F0KN@1|root,33TPA@2|Bacteria,2H2B7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4152346_1	1341151.ASZU01000008_gene1617	6.377e-44	181.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,27BIZ@186824|Thermoactinomycetaceae	91061|Bacilli	O	Subtilase family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
DYD2_k127_4152346_3	525904.Tter_1129	8.808e-05	53.0	COG3415@1|root,COG3415@2|Bacteria,2NPY9@2323|unclassified Bacteria	2|Bacteria	L	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,DUF3105,HTH_Tnp_IS630
DYD2_k127_4152346_0	266117.Rxyl_0961	3.134e-61	220.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
DYD2_k127_4152346_2	383372.Rcas_3979	7.948e-27	113.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi,376XW@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM LPPG domain	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
DYD2_k127_4161631_8	1304275.C41B8_12424	9.283e-21	93.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the class I fructose-bisphosphate aldolase family	alf1	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
DYD2_k127_4161631_10	1961.JOAK01000003_gene1503	4.199e-13	80.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
DYD2_k127_4161631_3	1961.JOAK01000003_gene1504	7.103e-71	251.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_4161631_6	1232410.KI421426_gene1402	7.182e-33	137.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,42TAG@68525|delta/epsilon subdivisions,2WPRH@28221|Deltaproteobacteria,43SJK@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_4161631_7	697281.Mahau_0484	1.116e-24	113.0	COG0365@1|root,COG1956@1|root,COG0365@2|Bacteria,COG1956@2|Bacteria,1TQTI@1239|Firmicutes,25AZ5@186801|Clostridia,42FPZ@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM AMP-dependent synthetase	-	-	6.2.1.1,6.2.1.2	ko:K01895,ko:K01896	ko00010,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01176,R01354	RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
DYD2_k127_4161631_2	1121926.AXWO01000003_gene647	1.467e-72	264.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
DYD2_k127_4161631_4	1121926.AXWO01000003_gene648	1.654e-65	234.0	COG0559@1|root,COG0559@2|Bacteria,2GNXY@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DYD2_k127_4161631_1	196162.Noca_2112	7.721e-78	274.0	COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
DYD2_k127_4161631_0	196162.Noca_2111	1.323e-86	293.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
DYD2_k127_4161631_5	1121448.DGI_3139	1.751e-60	218.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2M9W9@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DYD2_k127_4161631_11	10224.XP_006813604.1	0.000171	44.0	COG1304@1|root,KOG0538@2759|Eukaryota,38BCT@33154|Opisthokonta,3BA92@33208|Metazoa,3CU9T@33213|Bilateria	33208|Metazoa	C	very-long-chain-(S)-2-hydroxy-acid oxidase activity	HAO1	GO:0000166,GO:0001561,GO:0003674,GO:0003824,GO:0003973,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006066,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0008891,GO:0009056,GO:0009062,GO:0009441,GO:0009987,GO:0010181,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016614,GO:0016623,GO:0016899,GO:0016903,GO:0017144,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031974,GO:0032553,GO:0032787,GO:0033036,GO:0033365,GO:0034308,GO:0034310,GO:0034440,GO:0034613,GO:0034641,GO:0036094,GO:0042579,GO:0042737,GO:0042886,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046164,GO:0046296,GO:0046395,GO:0046907,GO:0047969,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055114,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K11517	ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00630,map01100,map01110,map01120,map01130,map01200,map04146	M00532	R00475	RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
DYD2_k127_4196010_0	1380347.JNII01000005_gene3420	5.494e-66	243.0	COG2172@1|root,COG2172@2|Bacteria,2GKU6@201174|Actinobacteria,4ESWM@85013|Frankiales	201174|Actinobacteria	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,MEDS
DYD2_k127_4196010_1	266117.Rxyl_2919	2.196e-50	201.0	COG2202@1|root,COG2203@1|root,COG2208@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKEF@201174|Actinobacteria,4CU1G@84995|Rubrobacteria	84995|Rubrobacteria	T	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,PAS_9,SpoIIE
DYD2_k127_4199089_0	1304275.C41B8_12424	1.426e-131	429.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the class I fructose-bisphosphate aldolase family	alf1	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
DYD2_k127_4199089_3	62928.azo3368	6.454e-27	117.0	COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,2VUIX@28216|Betaproteobacteria,2KX48@206389|Rhodocyclales	206389|Rhodocyclales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4199089_1	1122138.AQUZ01000015_gene6845	2.29e-70	255.0	COG0477@1|root,COG2814@2|Bacteria,2I8HS@201174|Actinobacteria,4DVK7@85009|Propionibacteriales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
DYD2_k127_4199089_2	665571.STHERM_c11820	1.301e-58	214.0	COG1028@1|root,COG1028@2|Bacteria	665571.STHERM_c11820|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
DYD2_k127_4211865_4	1048339.KB913029_gene2687	8.702e-11	73.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4211865_3	1415780.JPOG01000001_gene1140	2.389e-14	84.0	2C75R@1|root,2ZCK5@2|Bacteria,1NMP7@1224|Proteobacteria,1SHMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
DYD2_k127_4211865_0	58344.JOEL01000017_gene5948	8.545e-170	545.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria	201174|Actinobacteria	J	tRNA nucleotidyltransferase poly(A) polymerase	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
DYD2_k127_4211865_2	194867.ALBQ01000028_gene2359	1.077e-23	110.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2U6BE@28211|Alphaproteobacteria,2K4NC@204457|Sphingomonadales	204457|Sphingomonadales	S	enzyme related to lactoylglutathione lyase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
DYD2_k127_4211865_1	469383.Cwoe_1085	3.213e-29	120.0	COG0524@1|root,COG0524@2|Bacteria,2H514@201174|Actinobacteria,4CT2F@84995|Rubrobacteria	84995|Rubrobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
DYD2_k127_4234624_0	471857.Svir_04460	1.394e-125	415.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4DXC8@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DYD2_k127_4234624_1	645991.Sgly_0487	1.528e-57	207.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,2608Z@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DYD2_k127_4235175_9	1380354.JIAN01000008_gene3362	2.524e-20	107.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
DYD2_k127_4235175_11	222534.KB893714_gene1659	1.625e-12	69.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4EST1@85013|Frankiales	201174|Actinobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DYD2_k127_4235175_14	1168065.DOK_04818	6.016e-08	57.0	COG5276@1|root,COG5276@2|Bacteria,1R8ZW@1224|Proteobacteria,1S0TP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_4235175_10	243231.GSU0055	9.139e-15	81.0	COG3668@1|root,COG3668@2|Bacteria,1N97P@1224|Proteobacteria,42VMQ@68525|delta/epsilon subdivisions,2WSAV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
DYD2_k127_4235175_7	1223545.GS4_19_00610	1.382e-29	131.0	2EK7R@1|root,33DY3@2|Bacteria,2IPS3@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4238)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4238
DYD2_k127_4235175_8	1121877.JQKF01000093_gene2619	2.719e-25	110.0	COG4453@1|root,COG4453@2|Bacteria,2IT03@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1778)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1778
DYD2_k127_4235175_4	397278.JOJN01000007_gene3186	4.057e-58	210.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
DYD2_k127_4235175_1	67275.JOAP01000072_gene6532	3.415e-103	372.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
DYD2_k127_4235175_12	537007.BLAHAN_05129	2.602e-09	65.0	COG1813@1|root,COG1813@2|Bacteria,1UI13@1239|Firmicutes,25NNM@186801|Clostridia,3Y1Z4@572511|Blautia	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
DYD2_k127_4235175_15	1124991.MU9_75	1.016e-05	52.0	COG4679@1|root,COG4679@2|Bacteria	2|Bacteria	K	PFAM Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
DYD2_k127_4235175_18	356851.JOAN01000012_gene5091	0.0007338	47.0	COG4584@1|root,COG4584@2|Bacteria,2HKD7@201174|Actinobacteria,4DIH3@85008|Micromonosporales	201174|Actinobacteria	L	Helix-turn-helix domain of resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,rve
DYD2_k127_4235175_17	243164.DET1552	4.269e-05	48.0	COG1961@1|root,COG1961@2|Bacteria,2G7BH@200795|Chloroflexi,34DMJ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
DYD2_k127_4235175_13	1280946.HY29_12015	3.703e-08	67.0	COG3356@1|root,COG3356@2|Bacteria,1RJI0@1224|Proteobacteria,2UHQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Neutral alkaline nonlysosomal ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
DYD2_k127_4235175_6	316274.Haur_1630	7.682e-49	183.0	COG2258@1|root,COG2258@2|Bacteria	2|Bacteria	C	MOSC domain	yuaD	-	-	-	-	-	-	-	-	-	-	-	MOSC
DYD2_k127_4235175_0	1229780.BN381_100026	1.164e-145	488.0	COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,3UX0X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA helicase	helD	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C_2,Viral_helicase1
DYD2_k127_4235175_5	1128421.JAGA01000002_gene1417	3.612e-57	205.0	COG2178@1|root,COG2178@2|Bacteria,2NR1U@2323|unclassified Bacteria	2|Bacteria	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_4235175_2	443906.CMM_2446	1.717e-89	304.0	COG1210@1|root,COG1210@2|Bacteria,2I2EW@201174|Actinobacteria,4FKKH@85023|Microbacteriaceae	201174|Actinobacteria	M	Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DYD2_k127_4235175_3	351607.Acel_0165	8.691e-87	303.0	COG2199@1|root,COG2203@1|root,COG5000@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG5000@2|Bacteria,2IA4H@201174|Actinobacteria	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HAMP
DYD2_k127_4235175_16	1157490.EL26_19950	3.383e-05	49.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,27A2H@186823|Alicyclobacillaceae	91061|Bacilli	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
DYD2_k127_4245842_0	526225.Gobs_1720	2.632e-139	458.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4EURN@85013|Frankiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.9	ko:K00128,ko:K00131	ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00135,M00308,M00633	R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DYD2_k127_4245842_4	797209.ZOD2009_16563	7.405e-22	101.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2XXT7@28890|Euryarchaeota,23WEB@183963|Halobacteria	183963|Halobacteria	S	flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
DYD2_k127_4245842_3	1306174.JODP01000001_gene5160	2.429e-33	136.0	COG3877@1|root,COG3877@2|Bacteria,2IT3M@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
DYD2_k127_4245842_5	479435.Kfla_5620	1.874e-16	89.0	2B5R0@1|root,31YKI@2|Bacteria,2IPMA@201174|Actinobacteria,4DR93@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4245842_1	40571.JOEA01000005_gene4000	2.19e-133	448.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4E1QJ@85010|Pseudonocardiales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
DYD2_k127_4245842_2	1463825.JNXC01000008_gene1277	2.572e-98	339.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DZEF@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DYD2_k127_4263087_2	1120950.KB892709_gene4047	9.587e-32	139.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DTSS@85009|Propionibacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
DYD2_k127_4263087_1	1229780.BN381_100221	4.522e-34	135.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
DYD2_k127_4263087_0	1380354.JIAN01000006_gene886	2.587e-46	178.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4F23Y@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
DYD2_k127_4263087_3	743718.Isova_1960	1.338e-13	74.0	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria,4F3EE@85017|Promicromonosporaceae	201174|Actinobacteria	P	ABC transporter	mntB	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
DYD2_k127_4272145_0	1121472.AQWN01000006_gene1706	2.781e-292	921.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25ZYN@186807|Peptococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
DYD2_k127_4272145_4	1123023.JIAI01000012_gene9102	9.686e-90	314.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4DXFC@85010|Pseudonocardiales	201174|Actinobacteria	H	PFAM Mur ligase family, glutamate ligase domain	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
DYD2_k127_4272145_5	469371.Tbis_2469	4.291e-48	178.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4E3I2@85010|Pseudonocardiales	201174|Actinobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
DYD2_k127_4272145_7	1128421.JAGA01000002_gene375	2.576e-40	160.0	COG2003@1|root,COG2003@2|Bacteria,2NPI9@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
DYD2_k127_4272145_6	1254432.SCE1572_49140	1.13e-42	169.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,42PEY@68525|delta/epsilon subdivisions,2WJJ3@28221|Deltaproteobacteria,2YUIV@29|Myxococcales	28221|Deltaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
DYD2_k127_4272145_1	298654.FraEuI1c_1957	3.868e-169	536.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4ES3S@85013|Frankiales	201174|Actinobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
DYD2_k127_4272145_8	1223523.H340_24440	1.064e-33	143.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria	201174|Actinobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
DYD2_k127_4272145_9	298654.FraEuI1c_1959	3.288e-08	63.0	COG2891@1|root,COG2891@2|Bacteria,2GN0I@201174|Actinobacteria,4EWK3@85013|Frankiales	201174|Actinobacteria	M	rod shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
DYD2_k127_4272145_2	471852.Tcur_1542	3.427e-123	425.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4EHIA@85012|Streptosporangiales	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	FTSW_RODA_SPOVE,PBP_dimer,Transpeptidase
DYD2_k127_4272145_3	561175.KB894104_gene1145	7.447e-92	317.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4EFT6@85012|Streptosporangiales	201174|Actinobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
DYD2_k127_4288988_2	1380347.JNII01000006_gene1491	1.7e-20	98.0	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4ERVD@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS1	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
DYD2_k127_4288988_0	471852.Tcur_3224	8.026e-201	635.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4EI01@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
DYD2_k127_4288988_1	446468.Ndas_0745	1.793e-76	264.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4EFG5@85012|Streptosporangiales	201174|Actinobacteria	G	PEP-utilising enzyme, TIM barrel domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DYD2_k127_4301332_0	477641.MODMU_4483	3.301e-129	421.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4ERXY@85013|Frankiales	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
DYD2_k127_4301332_2	101510.RHA1_ro02743	8.761e-09	67.0	COG0741@1|root,COG0791@1|root,COG0741@2|Bacteria,COG0791@2|Bacteria,2GP5E@201174|Actinobacteria,4FX1K@85025|Nocardiaceae	201174|Actinobacteria	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,Peptidase_M23,SLT,SLT_2
DYD2_k127_4301332_3	1196323.ALKF01000176_gene3041	0.0002927	53.0	COG2866@1|root,COG3291@1|root,COG4724@1|root,COG2866@2|Bacteria,COG3291@2|Bacteria,COG4724@2|Bacteria,1TPGB@1239|Firmicutes,4HDJJ@91061|Bacilli,26RF7@186822|Paenibacillaceae	91061|Bacilli	G	endo-beta-N-acetylglucosaminidase	-	-	3.2.1.96	ko:K01227	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	-	-	Big_3,F5_F8_type_C,FIVAR,G5,Glyco_hydro_85,Gram_pos_anchor,PKD,YSIRK_signal
DYD2_k127_4301332_1	580340.Tlie_0700	7.515e-09	61.0	COG1030@1|root,COG1030@2|Bacteria,3TAG8@508458|Synergistetes	508458|Synergistetes	O	Membrane-bound serine protease (ClpP class)	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
DYD2_k127_432260_0	1382356.JQMP01000003_gene1584	7.626e-113	376.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
DYD2_k127_432260_1	2074.JNYD01000003_gene3462	6.022e-72	264.0	COG1073@1|root,COG1073@2|Bacteria,2IASV@201174|Actinobacteria,4E960@85010|Pseudonocardiales	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Peptidase_S9
DYD2_k127_4322695_3	36809.MAB_0427	2.118e-49	180.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,23ETB@1762|Mycobacteriaceae	201174|Actinobacteria	P	ABC transporter	dppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
DYD2_k127_4322695_2	1033734.CAET01000065_gene2260	5.214e-76	267.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,1ZC1H@1386|Bacillus	91061|Bacilli	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppC3	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DYD2_k127_4322695_1	1157632.AQWQ01000004_gene1412	7.116e-116	384.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	oppD1	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DYD2_k127_4322695_0	326427.Cagg_2964	2.84e-133	433.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3754I@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DYD2_k127_4322695_4	263358.VAB18032_00315	1.065e-09	71.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4D9S4@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DYD2_k127_4322695_5	1176165.CAJD01000015_gene1034	7.168e-06	48.0	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria,4FABV@85019|Brevibacteriaceae	201174|Actinobacteria	U	Preprotein translocase SecG subunit	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
DYD2_k127_4359104_6	28042.GU90_05300	1.209e-13	78.0	COG1841@1|root,COG1841@2|Bacteria,2GQV0@201174|Actinobacteria,4E6SV@85010|Pseudonocardiales	201174|Actinobacteria	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
DYD2_k127_4359104_1	656024.FsymDg_3944	3.022e-69	239.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4ES1E@85013|Frankiales	201174|Actinobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
DYD2_k127_4359104_3	1423734.JCM14202_1965	4.864e-36	140.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,3F6KN@33958|Lactobacillaceae	91061|Bacilli	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
DYD2_k127_4359104_0	1380390.JIAT01000011_gene2603	1.346e-70	243.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4CQ44@84995|Rubrobacteria	84995|Rubrobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
DYD2_k127_4359104_2	479433.Caci_0945	9.415e-55	194.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
DYD2_k127_4359104_4	396014.BF93_14460	6.413e-26	110.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4FD57@85020|Dermabacteraceae	201174|Actinobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
DYD2_k127_4359104_5	1158318.ATXC01000001_gene1262	4.093e-14	72.0	COG0094@1|root,COG0094@2|Bacteria,2G3N4@200783|Aquificae	200783|Aquificae	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
DYD2_k127_4395302_9	469383.Cwoe_1320	1.392e-08	55.0	COG0267@1|root,COG0267@2|Bacteria,2GQFG@201174|Actinobacteria,4CQU8@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
DYD2_k127_4395302_1	439235.Dalk_3912	2.552e-66	236.0	COG1028@1|root,COG1028@2|Bacteria,1MXFZ@1224|Proteobacteria,42Z2P@68525|delta/epsilon subdivisions,2WUJP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DYD2_k127_4395302_6	1463825.JNXC01000001_gene6121	1.153e-40	163.0	COG2030@1|root,COG2030@2|Bacteria,2GMVC@201174|Actinobacteria,4E3JC@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the UPF0336 family	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
DYD2_k127_4395302_5	1120936.KB907214_gene4504	1.323e-41	164.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4EIIF@85012|Streptosporangiales	201174|Actinobacteria	I	MaoC like domain	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
DYD2_k127_4395302_4	1382306.JNIM01000001_gene1358	5.33e-48	187.0	COG0215@1|root,COG1216@1|root,COG0215@2|Bacteria,COG1216@2|Bacteria,2G5Z0@200795|Chloroflexi	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
DYD2_k127_4395302_7	1229780.BN381_610018	5.557e-30	126.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,3UXIW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_4395302_10	370438.PTH_2794	1.215e-05	55.0	COG5662@1|root,COG5662@2|Bacteria,1VC8Y@1239|Firmicutes,24NRN@186801|Clostridia,263EZ@186807|Peptococcaceae	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
DYD2_k127_4395302_8	685727.REQ_36870	4.294e-10	66.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria,4G1M8@85025|Nocardiaceae	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
DYD2_k127_4395302_0	1229780.BN381_350058	5.716e-71	251.0	COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,3UWJ1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusG
DYD2_k127_4395302_2	188626.HMPREF0321_1192	1.042e-63	222.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,1ZVWM@145357|Dermacoccaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
DYD2_k127_4395302_3	446466.Cfla_2675	1.141e-57	205.0	COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4F0Y8@85016|Cellulomonadaceae	201174|Actinobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DYD2_k127_4398315_1	1048339.KB913029_gene4043	5.148e-26	124.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4398315_0	1151126.AQYI01000005_gene2492	5.052e-89	310.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4FKJM@85023|Microbacteriaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_4398315_2	1120950.KB892707_gene4878	8.819e-25	118.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4DNDP@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_4398315_3	585530.HMPREF0183_0440	6.029e-12	79.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4F8CJ@85019|Brevibacteriaceae	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
DYD2_k127_4399083_2	1128421.JAGA01000002_gene1152	1.233e-44	184.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2NR6B@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DYD2_k127_4399083_0	42256.RradSPS_0735	2.91e-75	260.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CPWA@84995|Rubrobacteria	84995|Rubrobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_4399083_1	1313172.YM304_02670	7.997e-52	188.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4CN9M@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
DYD2_k127_4399083_4	134676.ACPL_2958	1.631e-26	112.0	COG0745@1|root,COG0745@2|Bacteria	134676.ACPL_2958|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4399083_3	512565.AMIS_65160	4.511e-43	162.0	COG0467@1|root,COG0467@2|Bacteria,2I58C@201174|Actinobacteria,4DH7N@85008|Micromonosporales	201174|Actinobacteria	T	Circadian clock protein KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
DYD2_k127_4401040_3	1202532.FF52_10998	4.273e-05	55.0	COG1345@1|root,COG2911@1|root,COG3209@1|root,COG3386@1|root,COG4447@1|root,COG1345@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3386@2|Bacteria,COG4447@2|Bacteria,4NFVP@976|Bacteroidetes,1HY1K@117743|Flavobacteriia,2NSFX@237|Flavobacterium	976|Bacteroidetes	N	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	PA14
DYD2_k127_4401040_4	1288083.AUKR01000008_gene1706	4.66e-05	52.0	2FF8E@1|root,34769@2|Bacteria,2IQA2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4401040_2	1121377.KB906425_gene277	5.153e-16	93.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1WNI2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12
DYD2_k127_4401040_1	1157632.AQWQ01000016_gene3367	2.957e-32	145.0	COG3629@1|root,COG3629@2|Bacteria,2IBMM@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
DYD2_k127_4401040_0	1294143.H681_08090	5.483e-116	386.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,1S1BV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
DYD2_k127_4431089_2	633147.Olsu_0986	1.891e-25	109.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CVKY@84998|Coriobacteriia	84998|Coriobacteriia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
DYD2_k127_4431089_3	1203605.HMPREF1531_02085	4.341e-21	95.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4DRNP@85009|Propionibacteriales	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
DYD2_k127_4431089_1	760568.Desku_1307	8.185e-113	379.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25ZXR@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
DYD2_k127_4431089_0	1133850.SHJG_2901	3.007e-173	551.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
DYD2_k127_4431089_4	521096.Tpau_2574	6.935e-14	84.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
DYD2_k127_4457887_1	397278.JOJN01000003_gene1692	1.664e-29	132.0	COG0741@1|root,COG0791@1|root,COG0741@2|Bacteria,COG0791@2|Bacteria,2IF18@201174|Actinobacteria,4DN6C@85009|Propionibacteriales	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
DYD2_k127_4457887_2	525909.Afer_0819	2.336e-05	54.0	2CD9C@1|root,2ZWAS@2|Bacteria,2GYGD@201174|Actinobacteria,4CNXP@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4457887_0	397278.JOJN01000006_gene976	8.734e-79	271.0	COG1024@1|root,COG1024@2|Bacteria,2I7QX@201174|Actinobacteria,4DRJV@85009|Propionibacteriales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
DYD2_k127_4463582_3	649747.HMPREF0083_00365	2.664e-29	123.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H9TV@91061|Bacilli,26RBP@186822|Paenibacillaceae	91061|Bacilli	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
DYD2_k127_4463582_8	1313172.YM304_04050	6.278e-08	64.0	2FE68@1|root,34663@2|Bacteria,2H83B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4463582_7	765420.OSCT_2991	1.304e-09	69.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria	2|Bacteria	C	Cytochrome c	qcrC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0098822,GO:1901363,GO:1901564	1.8.2.2	ko:K00406,ko:K03889,ko:K17222,ko:K19713	ko00190,ko00920,ko01100,ko01120,ko02020,map00190,map00920,map01100,map01120,map02020	M00151,M00156,M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cytochrome_CBB3
DYD2_k127_4463582_2	1229780.BN381_450009	3.844e-44	169.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria	201174|Actinobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
DYD2_k127_4463582_1	1313172.YM304_04020	4.769e-55	207.0	COG1290@1|root,COG1290@2|Bacteria,2H1Y8@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
DYD2_k127_4463582_0	1313172.YM304_04010	4.146e-117	381.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome b/b6/petB	-	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
DYD2_k127_4463582_6	1229780.BN381_450012	1.68e-17	89.0	COG1143@1|root,COG1143@2|Bacteria,2H4NQ@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
DYD2_k127_4463582_5	1385515.N791_08070	7.611e-19	94.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,1SASG@1236|Gammaproteobacteria,1X798@135614|Xanthomonadales	135614|Xanthomonadales	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
DYD2_k127_4463582_4	1048339.KB913029_gene166	1.02e-21	109.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4ET99@85013|Frankiales	201174|Actinobacteria	CO	Alkyl hydroperoxide reductase Thiol specific antioxidant	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
DYD2_k127_4466006_2	1122239.AULS01000003_gene2690	2.912e-13	76.0	COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,4FR7S@85023|Microbacteriaceae	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
DYD2_k127_4466006_0	414996.IL38_04435	5.395e-127	417.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,408VE@622450|Actinopolysporales	201174|Actinobacteria	C	NADH dehydrogenase	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
DYD2_k127_4466006_1	471853.Bcav_3221	1.125e-48	177.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
DYD2_k127_4504216_9	58123.JOFJ01000025_gene3391	5.871e-17	88.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
DYD2_k127_4504216_5	1380370.JIBA01000003_gene2733	1.254e-58	227.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria,4FFVW@85021|Intrasporangiaceae	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
DYD2_k127_4504216_0	471852.Tcur_1852	3.169e-180	584.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system protein e	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DYD2_k127_4504216_3	351607.Acel_0975	2.591e-62	231.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,4EVMD@85013|Frankiales	201174|Actinobacteria	D	Evidence 2b Function of strongly homologous gene	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
DYD2_k127_4504216_10	644966.Tmar_1210	4.378e-16	89.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,3WDPT@538999|Clostridiales incertae sedis	186801|Clostridia	U	TIGRFAM Flp pilus assembly protein CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
DYD2_k127_4504216_13	58123.JOFJ01000025_gene3386	1.972e-05	57.0	COG4961@1|root,COG4961@2|Bacteria,2I4JJ@201174|Actinobacteria	201174|Actinobacteria	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
DYD2_k127_4504216_16	1121946.AUAX01000006_gene3408	0.0006705	49.0	COG4961@1|root,COG4961@2|Bacteria,2HWWQ@201174|Actinobacteria,4DKKI@85008|Micromonosporales	201174|Actinobacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
DYD2_k127_4504216_12	1151119.KB895490_gene2183	3.562e-06	53.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Class_IIIsignal,Flp_Fap
DYD2_k127_4504216_7	479432.Sros_3331	5.902e-38	150.0	COG2197@1|root,COG2197@2|Bacteria,2IFE7@201174|Actinobacteria,4ENBQ@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DYD2_k127_4504216_15	1089545.KB913037_gene478	0.0001814	51.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4DYCS@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
DYD2_k127_4504216_2	309801.trd_1285	2.732e-66	241.0	COG0463@1|root,COG0463@2|Bacteria,2G5X5@200795|Chloroflexi,27XQE@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_4504216_11	867903.ThesuDRAFT_00380	6.718e-09	68.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1V33I@1239|Firmicutes	1239|Firmicutes	IM	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.7.74,2.7.8.34	ko:K07281,ko:K07291	ko00562,map00562	-	R09669,R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,NTP_transf_3
DYD2_k127_4504216_6	383372.Rcas_3942	3.244e-55	210.0	COG0438@1|root,COG0438@2|Bacteria,2G99J@200795|Chloroflexi,374RQ@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_4504216_1	1033730.CAHG01000014_gene1779	9.867e-95	347.0	COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
DYD2_k127_4504216_8	479434.Sthe_2271	1.166e-26	128.0	COG5305@1|root,COG5305@2|Bacteria,2G7AA@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DYD2_k127_4504216_4	436229.JOEH01000008_gene4097	3.182e-61	224.0	COG4124@1|root,COG4124@2|Bacteria,2GMW5@201174|Actinobacteria,2NMCQ@228398|Streptacidiphilus	201174|Actinobacteria	G	Glycosyl hydrolase family 26	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
DYD2_k127_4504216_14	1128421.JAGA01000002_gene757	0.0001448	54.0	COG2244@1|root,COG2244@2|Bacteria,2NPWA@2323|unclassified Bacteria	2|Bacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
DYD2_k127_4507741_7	1229203.KI301992_gene1794	3.971e-26	127.0	2F0KN@1|root,33TPA@2|Bacteria,2H2B7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4507741_5	1463854.JOHT01000015_gene5320	9.563e-42	163.0	COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria	201174|Actinobacteria	S	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
DYD2_k127_4507741_0	1120950.KB892771_gene1287	1.445e-112	377.0	COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4DPZ7@85009|Propionibacteriales	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
DYD2_k127_4507741_1	1380390.JIAT01000009_gene2069	1.139e-98	331.0	COG0697@1|root,COG0697@2|Bacteria,2I9E0@201174|Actinobacteria,4CPT5@84995|Rubrobacteria	84995|Rubrobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_4507741_2	526225.Gobs_2490	4.909e-89	302.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,4EUCQ@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
DYD2_k127_4507741_3	1146883.BLASA_2785	1.045e-84	295.0	COG0204@1|root,COG0204@2|Bacteria,2I8I4@201174|Actinobacteria,4EVF7@85013|Frankiales	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
DYD2_k127_4507741_8	525268.HMPREF0308_0111	1.095e-17	96.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,22MWQ@1653|Corynebacteriaceae	201174|Actinobacteria	P	ABC-type molybdate transport system periplasmic component	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
DYD2_k127_4507741_4	469383.Cwoe_3463	1.482e-66	244.0	COG0555@1|root,COG0555@2|Bacteria,2I4C5@201174|Actinobacteria,4CQ7S@84995|Rubrobacteria	84995|Rubrobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
DYD2_k127_4507741_6	443218.AS9A_2968	8.185e-33	129.0	COG2146@1|root,COG2146@2|Bacteria,2GVQV@201174|Actinobacteria,23EGB@1762|Mycobacteriaceae	201174|Actinobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
DYD2_k127_4515429_0	1461580.CCAS010000009_gene1253	3.501e-114	374.0	COG0235@1|root,COG0235@2|Bacteria,1TZDD@1239|Firmicutes,4HDVI@91061|Bacilli,1ZET4@1386|Bacillus	91061|Bacilli	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
DYD2_k127_4525774_1	749927.AMED_0475	3.144e-52	194.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4E2HU@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_4525774_0	1120950.KB892707_gene4920	1.206e-90	321.0	COG3875@1|root,COG3875@2|Bacteria,2IAM4@201174|Actinobacteria,4DPEW@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DYD2_k127_4534310_2	882082.SaccyDRAFT_2705	2.566e-101	335.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4DZ94@85010|Pseudonocardiales	2|Bacteria	E	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
DYD2_k127_4534310_4	479432.Sros_1729	8.619e-05	55.0	2DKXG@1|root,30RUJ@2|Bacteria,2GM9V@201174|Actinobacteria,4EIFQ@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3352
DYD2_k127_4534310_3	211114.JOEF01000043_gene6087	7.994e-18	97.0	COG2215@1|root,COG2215@2|Bacteria,2H0S3@201174|Actinobacteria,4E8I1@85010|Pseudonocardiales	201174|Actinobacteria	S	High-affinity nickel-transport protein	-	-	-	-	-	-	-	-	-	-	-	-	NicO
DYD2_k127_4534310_1	1048339.KB913029_gene3450	4.357e-159	520.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4ES0M@85013|Frankiales	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
DYD2_k127_4534310_0	1449353.JQMQ01000005_gene2094	3.417e-177	566.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,2NHY5@228398|Streptacidiphilus	201174|Actinobacteria	J	Amidase	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
DYD2_k127_4542064_2	1150864.MILUP08_40621	2.47e-08	67.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria,4DBAR@85008|Micromonosporales	201174|Actinobacteria	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
DYD2_k127_4542064_1	35754.JNYJ01000010_gene1693	1.428e-84	294.0	COG2208@1|root,COG2208@2|Bacteria,2GNG4@201174|Actinobacteria,4DB4U@85008|Micromonosporales	201174|Actinobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
DYD2_k127_4542064_0	457429.ABJI02000106_gene1220	1.284e-90	317.0	COG1470@1|root,COG3537@1|root,COG1470@2|Bacteria,COG3537@2|Bacteria,2GKYM@201174|Actinobacteria	201174|Actinobacteria	G	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92,NPCBM_assoc
DYD2_k127_4560223_1	1168065.DOK_04818	4.332e-146	478.0	COG5276@1|root,COG5276@2|Bacteria,1R8ZW@1224|Proteobacteria,1S0TP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_4560223_2	1408422.JHYF01000011_gene3399	5.507e-11	66.0	COG3478@1|root,COG3478@2|Bacteria,1VKSK@1239|Firmicutes,24WD3@186801|Clostridia	186801|Clostridia	S	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4560223_0	58123.JOFJ01000004_gene1835	2.866e-225	714.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4EGCZ@85012|Streptosporangiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DYD2_k127_4561802_0	1048339.KB913029_gene3712	2.437e-71	245.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
DYD2_k127_4561802_1	1048339.KB913029_gene4043	1.616e-19	102.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4562629_4	103733.JNYO01000042_gene6105	3.383e-05	49.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DYXD@85010|Pseudonocardiales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_4562629_0	2074.JNYD01000007_gene2100	3.001e-79	280.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria,4DY5S@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM YibE F-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
DYD2_k127_4562629_3	1123388.AQWU01000045_gene1644	3.042e-10	64.0	2A1Q0@1|root,30PYE@2|Bacteria,1WKGP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
DYD2_k127_4562629_2	1123386.AUIW01000001_gene314	5.681e-35	142.0	COG2402@1|root,COG2402@2|Bacteria,1WJXR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
DYD2_k127_4562629_1	1110697.NCAST_32_05440	1.185e-72	262.0	COG2220@1|root,COG2220@2|Bacteria,2IT2Z@201174|Actinobacteria,4FXF0@85025|Nocardiaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_3
DYD2_k127_4564826_1	1123242.JH636435_gene2022	9.468e-11	68.0	COG0354@1|root,COG0354@2|Bacteria,2IZWI@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
DYD2_k127_4564826_0	84531.JMTZ01000012_gene2935	3.653e-56	212.0	COG1404@1|root,COG1404@2|Bacteria,1REF1@1224|Proteobacteria	1224|Proteobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_M6,Peptidase_S8
DYD2_k127_4634189_0	1193181.BN10_890012	2.31e-69	242.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4FEWH@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_4634189_4	926550.CLDAP_37610	1.966e-28	127.0	COG5653@1|root,COG5653@2|Bacteria,2G6Z0@200795|Chloroflexi	200795|Chloroflexi	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
DYD2_k127_4634189_2	471852.Tcur_0663	1.607e-37	148.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4EJT0@85012|Streptosporangiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
DYD2_k127_4634189_1	446462.Amir_1460	2.042e-47	191.0	COG2936@1|root,COG2936@2|Bacteria,2GJ2K@201174|Actinobacteria,4DXFY@85010|Pseudonocardiales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_4634189_3	287986.DV20_01930	8.231e-35	140.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4DYR1@85010|Pseudonocardiales	201174|Actinobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
DYD2_k127_4634263_0	45157.CMQ436CT	8.088e-91	310.0	COG1304@1|root,KOG0538@2759|Eukaryota	2759|Eukaryota	C	very-long-chain-(S)-2-hydroxy-acid oxidase activity	GOX	GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0003674,GO:0003824,GO:0003973,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005777,GO:0005829,GO:0005840,GO:0005911,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008891,GO:0009058,GO:0009506,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009725,GO:0009735,GO:0009853,GO:0009987,GO:0010033,GO:0010109,GO:0010204,GO:0016020,GO:0016032,GO:0016491,GO:0016614,GO:0016899,GO:0016999,GO:0017000,GO:0017144,GO:0019048,GO:0019222,GO:0022626,GO:0023052,GO:0030054,GO:0031323,GO:0031347,GO:0031349,GO:0032991,GO:0035821,GO:0042221,GO:0042579,GO:0042742,GO:0042743,GO:0043094,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044003,GO:0044237,GO:0044249,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045088,GO:0045089,GO:0048046,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0055044,GO:0055114,GO:0065007,GO:0072593,GO:0080134,GO:0098542,GO:1903409,GO:1990904	1.1.3.15	ko:K11517,ko:K13344	ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00630,map01100,map01110,map01120,map01130,map01200,map04146	M00532	R00475	RC00042	ko00000,ko00001,ko00002,ko01000	3.A.20.1	-	-	FMN_dh
DYD2_k127_4634263_5	525904.Tter_0247	1.848e-11	75.0	COG3794@1|root,COG3794@2|Bacteria,2NRPQ@2323|unclassified Bacteria	2|Bacteria	C	blue (type 1) copper	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cupredoxin_1
DYD2_k127_4634263_3	1449044.JMLE01000001_gene4144	1.363e-40	169.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,1WANS@1268|Micrococcaceae	201174|Actinobacteria	S	Hydrolase of the alpha beta-hydrolase	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
DYD2_k127_4634263_4	1123024.AUII01000018_gene3821	2.93e-39	158.0	COG0500@1|root,COG2226@2|Bacteria,2HIHA@201174|Actinobacteria,4DY0M@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DYD2_k127_4634263_2	1429046.RR21198_5621	4.702e-63	240.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4FX0X@85025|Nocardiaceae	201174|Actinobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
DYD2_k127_4634263_1	648996.Theam_0136	1.458e-79	271.0	COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae	200783|Aquificae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
DYD2_k127_4644234_2	928724.SacglDRAFT_01027	3.738e-63	226.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4DXDQ@85010|Pseudonocardiales	201174|Actinobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
DYD2_k127_4644234_1	269800.Tfu_0651	3.461e-76	261.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4EGGX@85012|Streptosporangiales	201174|Actinobacteria	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
DYD2_k127_4644234_9	219305.MCAG_04247	5.983e-13	72.0	COG0333@1|root,COG0333@2|Bacteria,2GQP3@201174|Actinobacteria,4DFJS@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
DYD2_k127_4644234_6	882082.SaccyDRAFT_1094	1.409e-30	128.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,4E2ZT@85010|Pseudonocardiales	201174|Actinobacteria	S	metal-binding protein	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
DYD2_k127_4644234_8	944560.HMPREF9058_2066	5.372e-15	82.0	COG0711@1|root,COG0711@2|Bacteria,2GNBF@201174|Actinobacteria,4D4AE@85005|Actinomycetales	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4644234_4	208444.JNYY01000010_gene2650	2.954e-45	168.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4E33S@85010|Pseudonocardiales	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DYD2_k127_4644234_5	931627.MycrhDRAFT_1919	8.456e-32	132.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,239DU@1762|Mycobacteriaceae	201174|Actinobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
DYD2_k127_4644234_0	292459.STH1384	6.487e-174	570.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
DYD2_k127_4644234_7	471852.Tcur_3439	5.878e-25	104.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4EKE3@85012|Streptosporangiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
DYD2_k127_4644234_3	1121351.AUAP01000002_gene405	8.679e-50	188.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VHWQ@28216|Betaproteobacteria,2KPQE@206351|Neisseriales	206351|Neisseriales	H	Psort location Cytoplasmic, score	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
DYD2_k127_4656629_3	518766.Rmar_1854	2.071e-39	164.0	COG0438@1|root,COG0438@2|Bacteria,4NH7K@976|Bacteroidetes	976|Bacteroidetes	M	Pfam Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_4656629_1	1123065.ATWL01000023_gene3606	1.633e-50	199.0	COG0438@1|root,COG0438@2|Bacteria,2I3KI@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_4656629_2	1211579.PP4_39750	1.564e-45	183.0	COG0438@1|root,COG0438@2|Bacteria,1MYJ6@1224|Proteobacteria,1S89E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_4656629_0	562973.HMPREF0059_00460	2.471e-73	255.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4D3DP@85005|Actinomycetales	201174|Actinobacteria	GM	ABC transporter, ATP-binding protein	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
DYD2_k127_4656629_4	1239962.C943_01576	3.251e-28	124.0	COG1682@1|root,COG1682@2|Bacteria,4NF36@976|Bacteroidetes,47NFE@768503|Cytophagia	976|Bacteroidetes	GM	PFAM ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
DYD2_k127_4659953_14	871968.DESME_10540	3.384e-17	85.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,26058@186807|Peptococcaceae	186801|Clostridia	NU	secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DYD2_k127_4659953_12	118168.MC7420_7725	7.694e-25	121.0	COG0586@1|root,COG0586@2|Bacteria,1G184@1117|Cyanobacteria,1H7XY@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
DYD2_k127_4659953_16	1009370.ALO_03026	3.288e-10	66.0	COG0730@1|root,COG0730@2|Bacteria,1VAFU@1239|Firmicutes,4H5FP@909932|Negativicutes	909932|Negativicutes	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
DYD2_k127_4659953_15	1122238.AULR01000010_gene248	2.514e-12	77.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4FNYV@85023|Microbacteriaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
DYD2_k127_4659953_17	479432.Sros_9371	2.409e-08	67.0	COG3170@1|root,COG3170@2|Bacteria,2GN00@201174|Actinobacteria,4EFQZ@85012|Streptosporangiales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4659953_5	656024.FsymDg_4537	8.432e-75	277.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4ERF4@85013|Frankiales	201174|Actinobacteria	KLT	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	mviN	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
DYD2_k127_4659953_11	146922.JOFU01000005_gene7113	1.4e-25	123.0	COG0515@1|root,COG0515@2|Bacteria,2HMAN@201174|Actinobacteria	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
DYD2_k127_4659953_10	469371.Tbis_3576	3.981e-32	137.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4DXS2@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_4659953_2	1160137.KB907309_gene5991	2.353e-122	399.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4FU6S@85025|Nocardiaceae	201174|Actinobacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DYD2_k127_4659953_7	485913.Krac_4325	5.569e-72	258.0	COG4948@1|root,COG4948@2|Bacteria,2G7K9@200795|Chloroflexi	200795|Chloroflexi	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
DYD2_k127_4659953_0	365528.KB891215_gene2619	5.519e-279	881.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4ES10@85013|Frankiales	201174|Actinobacteria	E	PFAM Peptidase M1, membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
DYD2_k127_4659953_9	710685.MycrhN_1808	7.271e-40	150.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,239Y7@1762|Mycobacteriaceae	201174|Actinobacteria	O	belongs to the thioredoxin family	trxC	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DYD2_k127_4659953_6	1122138.AQUZ01000007_gene3174	4.76e-74	261.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria,4DN51@85009|Propionibacteriales	201174|Actinobacteria	M	Ami_3	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
DYD2_k127_4659953_19	1229780.BN381_330001	0.000229	51.0	COG1404@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4932@2|Bacteria,2IFXI@201174|Actinobacteria	201174|Actinobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
DYD2_k127_4659953_8	405948.SACE_7387	1.427e-44	171.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4DXW4@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_4659953_1	485915.Dret_1928	5.821e-170	542.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2M8VQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_4659953_4	298653.Franean1_7332	3.996e-85	294.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4ERK5@85013|Frankiales	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
DYD2_k127_4659953_3	1121335.Clst_0008	8.896e-95	318.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WGTZ@541000|Ruminococcaceae	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
DYD2_k127_4659953_13	1081644.IMCC13023_02520	1.59e-19	96.0	COG0357@1|root,COG0357@2|Bacteria,2GM9Z@201174|Actinobacteria,4FKMS@85023|Microbacteriaceae	201174|Actinobacteria	M	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
DYD2_k127_4659953_18	997346.HMPREF9374_2511	6.473e-08	55.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,4HHHU@91061|Bacilli,27C5J@186824|Thermoactinomycetaceae	91061|Bacilli	S	Jag_N	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
DYD2_k127_4676580_3	1463934.JOCF01000030_gene4959	2.806e-06	58.0	2E6WZ@1|root,331GF@2|Bacteria,2IFC6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4676580_2	1429916.X566_02455	2.14e-30	125.0	COG1051@1|root,COG1051@2|Bacteria,1N1KH@1224|Proteobacteria,2UDI2@28211|Alphaproteobacteria,3JYZ5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	MA20_42070	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_4676580_1	1125779.HMPREF1219_01993	2.813e-56	205.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,22K7D@1653|Corynebacteriaceae	201174|Actinobacteria	G	Archaeal fructose-16-bisphosphatase and related enzymes of inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008934,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016053,GO:0016137,GO:0016138,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
DYD2_k127_4676580_0	1463895.JODA01000018_gene5927	6.783e-122	402.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	mmgC	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_4741903_0	1382356.JQMP01000001_gene827	1.449e-70	245.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27Y34@189775|Thermomicrobia	189775|Thermomicrobia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DYD2_k127_4741903_1	1157635.KB892001_gene2589	2.159e-67	239.0	COG0204@1|root,COG0204@2|Bacteria,2GKM6@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	plsC1	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
DYD2_k127_4741903_2	1048339.KB913029_gene3185	4.645e-32	128.0	COG2159@1|root,COG2159@2|Bacteria,2H94T@201174|Actinobacteria,4EWGY@85013|Frankiales	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_474920_6	469371.Tbis_3304	7.814e-05	47.0	COG1877@1|root,COG1877@2|Bacteria,2GMKW@201174|Actinobacteria,4EAVY@85010|Pseudonocardiales	201174|Actinobacteria	G	Trehalose-phosphatase	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
DYD2_k127_474920_0	1246474.ANBE01000003_gene1971	4.507e-115	386.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4EGDH@85012|Streptosporangiales	201174|Actinobacteria	G	Glycosyltransferase family 20	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
DYD2_k127_474920_5	293826.Amet_2457	4.177e-38	159.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EAC@31979|Clostridiaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
DYD2_k127_474920_4	469383.Cwoe_4496	3.92e-38	155.0	COG0704@1|root,COG0704@2|Bacteria,2HGEG@201174|Actinobacteria,4CPTJ@84995|Rubrobacteria	84995|Rubrobacteria	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DYD2_k127_474920_1	1288083.AUKR01000017_gene2573	7.018e-112	372.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DYD2_k127_474920_3	555079.Toce_0356	2.604e-91	316.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,42F9B@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DYD2_k127_474920_2	1146883.BLASA_4537	2.501e-100	334.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DYD2_k127_4751953_0	1244869.H261_01547	2.575e-123	397.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria,2JWSB@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
DYD2_k127_4751953_1	351627.Csac_0881	3.423e-103	346.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,42ES6@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
DYD2_k127_4751953_2	222534.KB893783_gene5309	2.688e-36	155.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4ERCW@85013|Frankiales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
DYD2_k127_4758655_4	1122214.AQWH01000003_gene4097	4.291e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_4758655_0	1137271.AZUM01000013_gene4368	6.776e-204	665.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4DY13@85010|Pseudonocardiales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
DYD2_k127_4758655_1	266940.Krad_1135	6.86e-189	610.0	COG0465@1|root,COG0465@2|Bacteria,2I9X7@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the AAA ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
DYD2_k127_4758655_3	1500257.JQNM01000003_gene5303	4.361e-101	363.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
DYD2_k127_4758655_2	35754.JNYJ01000044_gene4354	1.147e-134	445.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4DHP7@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
DYD2_k127_476080_4	1144275.COCOR_05364	6.062e-06	57.0	COG5549@1|root,COG5549@2|Bacteria,1PBXR@1224|Proteobacteria,43864@68525|delta/epsilon subdivisions,2X0VV@28221|Deltaproteobacteria,2YVXH@29|Myxococcales	28221|Deltaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
DYD2_k127_476080_3	926569.ANT_04910	3.325e-25	110.0	COG1765@1|root,COG1765@2|Bacteria,2G978@200795|Chloroflexi	200795|Chloroflexi	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
DYD2_k127_476080_1	2074.JNYD01000003_gene3655	7.875e-98	331.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4DXZ6@85010|Pseudonocardiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
DYD2_k127_476080_0	28444.JODQ01000001_gene2321	2.369e-146	477.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4EH93@85012|Streptosporangiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
DYD2_k127_476080_2	1120797.KB908256_gene2068	1.148e-31	125.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,233UW@1762|Mycobacteriaceae	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DYD2_k127_4763490_4	1304875.JAFZ01000001_gene1089	4.417e-08	64.0	COG2721@1|root,COG2721@2|Bacteria,3TAQD@508458|Synergistetes	508458|Synergistetes	G	D-galactarate dehydratase altronate hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	GD_AH_C
DYD2_k127_4763490_2	298655.KI912267_gene7140	1.12e-17	95.0	COG0577@1|root,COG0577@2|Bacteria,2GWZR@201174|Actinobacteria	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
DYD2_k127_4763490_3	1463895.JODA01000014_gene1479	1.686e-11	78.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2GN4X@201174|Actinobacteria	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DYD2_k127_4763490_1	28444.JODQ01000001_gene2422	8.143e-88	297.0	COG1136@1|root,COG1136@2|Bacteria,2IDE8@201174|Actinobacteria	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_4763490_0	1380356.JNIK01000014_gene3473	7.41e-151	488.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GJRI@201174|Actinobacteria,4EU4G@85013|Frankiales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
DYD2_k127_4801026_8	1283283.ATXA01000004_gene4267	2.525e-08	55.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4ERQ7@85013|Frankiales	201174|Actinobacteria	T	PFAM PhoH family protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
DYD2_k127_4801026_6	1380393.JHVP01000006_gene3882	3.362e-25	112.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4ESS6@85013|Frankiales	201174|Actinobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
DYD2_k127_4801026_1	1121877.JQKF01000022_gene2275	1.31e-93	322.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4CP58@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
DYD2_k127_4801026_2	349520.PPE_03176	1.403e-85	295.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,26SJF@186822|Paenibacillaceae	91061|Bacilli	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
DYD2_k127_4801026_5	469371.Tbis_1176	1.169e-59	214.0	COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4DYII@85010|Pseudonocardiales	201174|Actinobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
DYD2_k127_4801026_3	1121355.KB903379_gene675	2.607e-66	234.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,22JXS@1653|Corynebacteriaceae	201174|Actinobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110	-	R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
DYD2_k127_4801026_0	710686.Mycsm_00144	2.485e-100	347.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae	201174|Actinobacteria	IT	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
DYD2_k127_4801026_4	1210045.ALNP01000017_gene1730	7.166e-61	213.0	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS2	-	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
DYD2_k127_4813844_1	525909.Afer_0459	5.737e-87	292.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
DYD2_k127_4813844_2	1109445.AGSX01000108_gene1216	9.363e-47	173.0	COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1Z08C@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	Sodium sulfate symporter family	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
DYD2_k127_4813844_0	96561.Dole_1094	5.032e-112	374.0	COG0471@1|root,COG0490@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MMR4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp,TrkA_C
DYD2_k127_4813844_3	298655.KI912267_gene7582	1.634e-22	103.0	COG2149@1|root,COG2149@2|Bacteria,2GQU9@201174|Actinobacteria,4EWT6@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
DYD2_k127_4813844_4	525909.Afer_0459	8.18e-21	94.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
DYD2_k127_4820767_3	68219.JNXI01000019_gene7517	2.74e-137	447.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE25	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_4820767_7	1121957.ATVL01000006_gene3095	6.603e-36	142.0	COG3296@1|root,COG3296@2|Bacteria,4NQGV@976|Bacteroidetes,47S3T@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870,SHOCT
DYD2_k127_4820767_0	1238182.C882_0318	1.944e-199	629.0	COG0604@1|root,COG2905@1|root,COG0604@2|Bacteria,COG2905@2|Bacteria,1MXIK@1224|Proteobacteria,2TQPR@28211|Alphaproteobacteria,2JPMR@204441|Rhodospirillales	28211|Alphaproteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	ccrA	-	1.1.1.1,1.3.1.85	ko:K00001,ko:K14446	ko00010,ko00071,ko00350,ko00625,ko00626,ko00630,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00630,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220	M00373	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R09291	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC02481	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DYD2_k127_4820767_5	861299.J421_0915	3.269e-79	283.0	COG0612@1|root,COG0612@2|Bacteria,1ZT9J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DYD2_k127_4820767_4	861299.J421_0916	1.448e-106	368.0	COG0612@1|root,COG0612@2|Bacteria,1ZSVK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DYD2_k127_4820767_2	1121877.JQKF01000011_gene378	3.875e-148	479.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_4820767_6	28444.JODQ01000011_gene3448	2.413e-47	173.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4EJNV@85012|Streptosporangiales	201174|Actinobacteria	E	Glyoxalase-like domain	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
DYD2_k127_4820767_8	1047013.AQSP01000132_gene1720	1.439e-11	76.0	COG0392@1|root,COG0392@2|Bacteria,2NPJC@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
DYD2_k127_4820767_1	525909.Afer_0231	1.096e-177	565.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMPB@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
DYD2_k127_4833408_2	1394178.AWOO02000020_gene7377	3.708e-28	119.0	COG0491@1|root,COG0491@2|Bacteria,2I9GW@201174|Actinobacteria,4EGY5@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DYD2_k127_4833408_1	300852.55772717	5.02e-74	256.0	COG0410@1|root,COG0410@2|Bacteria,1WJM5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type branched-chain amino acid transport systems ATPase component	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DYD2_k127_4833408_0	1120973.AQXL01000133_gene1770	3.673e-83	308.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1UVX8@1239|Firmicutes,4I2Q1@91061|Bacilli,2790H@186823|Alicyclobacillaceae	91061|Bacilli	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DYD2_k127_4854682_0	1122622.ATWJ01000002_gene800	2.121e-116	399.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
DYD2_k127_4854682_1	1278073.MYSTI_03841	6.848e-12	71.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	proV	-	3.6.3.32	ko:K02000,ko:K05847	ko02010,map02010	M00208,M00209	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS,cNMP_binding
DYD2_k127_4854682_2	414684.RC1_2443	5.612e-10	70.0	COG0025@1|root,COG2905@1|root,COG0025@2|Bacteria,COG2905@2|Bacteria,1MW5T@1224|Proteobacteria,2TSHB@28211|Alphaproteobacteria,2JQD0@204441|Rhodospirillales	204441|Rhodospirillales	PT	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,cNMP_binding
DYD2_k127_4854682_3	44056.XP_009041144.1	3.482e-09	64.0	COG2072@1|root,KOG1399@2759|Eukaryota	2759|Eukaryota	P	N,N-dimethylaniline monooxygenase activity	-	-	1.14.13.8	ko:K00485	ko00982,ko01120,map00982,map01120	-	R08266	RC02233	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
DYD2_k127_4854857_1	479434.Sthe_1582	8.043e-90	310.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia	189775|Thermomicrobia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
DYD2_k127_4854857_0	1007103.AFHW01000140_gene3949	4.934e-202	646.0	COG0843@1|root,COG0843@2|Bacteria,1TP2U@1239|Firmicutes,4HA4X@91061|Bacilli,26SFP@186822|Paenibacillaceae	91061|Bacilli	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
DYD2_k127_4854857_2	536019.Mesop_4405	3.41e-26	109.0	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_9
DYD2_k127_485785_0	1192034.CAP_4201	1.42e-30	132.0	COG3356@1|root,COG3356@2|Bacteria,1Q66U@1224|Proteobacteria,4358C@68525|delta/epsilon subdivisions,2WZJF@28221|Deltaproteobacteria,2Z29I@29|Myxococcales	28221|Deltaproteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
DYD2_k127_4858080_2	65497.JODV01000003_gene4510	1.336e-77	272.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4E04X@85010|Pseudonocardiales	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	sucB	GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008289,GO:0009405,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0030312,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0043177,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051704,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DYD2_k127_4858080_3	867903.ThesuDRAFT_01205	9.002e-61	219.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia	186801|Clostridia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
DYD2_k127_4858080_0	469371.Tbis_1266	2.179e-113	375.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4DZPM@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
DYD2_k127_4858080_4	675635.Psed_2382	2.452e-08	60.0	COG1366@1|root,COG1366@2|Bacteria,2GQY5@201174|Actinobacteria,4E6VT@85010|Pseudonocardiales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
DYD2_k127_4858080_1	35754.JNYJ01000074_gene2562	3.806e-81	302.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria	201174|Actinobacteria	T	protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c_2,SpoIIE
DYD2_k127_4867172_3	196162.Noca_4889	2.197e-53	193.0	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria	2|Bacteria	S	DsrE/DsrF-like family	-	-	-	ko:K06039,ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE
DYD2_k127_4867172_5	196162.Noca_4890	3.842e-37	149.0	COG0425@1|root,COG0425@2|Bacteria,2GSNH@201174|Actinobacteria	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
DYD2_k127_4867172_2	1123024.AUII01000010_gene679	1.104e-84	286.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,2I98A@201174|Actinobacteria,4E0T5@85010|Pseudonocardiales	201174|Actinobacteria	KP	PFAM Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
DYD2_k127_4867172_1	1214101.BN159_4295	2.808e-102	352.0	COG0491@1|root,COG2897@1|root,COG0491@2|Bacteria,COG2897@2|Bacteria,2GN50@201174|Actinobacteria	201174|Actinobacteria	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
DYD2_k127_4867172_0	1123024.AUII01000010_gene684	1.056e-167	546.0	COG0477@1|root,COG2814@2|Bacteria,2GNBV@201174|Actinobacteria,4E2F7@85010|Pseudonocardiales	201174|Actinobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_4867172_4	298653.Franean1_5788	1.32e-38	145.0	COG2514@1|root,COG2514@2|Bacteria,2GUZK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
DYD2_k127_4894684_0	1003195.SCAT_4858	8.575e-165	526.0	COG2185@1|root,COG2185@2|Bacteria,2I2N3@201174|Actinobacteria	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	meaA	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
DYD2_k127_4894684_4	710696.Intca_0768	7.09e-18	91.0	2AWFS@1|root,31NC1@2|Bacteria,2IMS0@201174|Actinobacteria,4FH76@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4894684_5	351607.Acel_0515	1.144e-13	78.0	2BM3X@1|root,33KY1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4894684_3	1223523.H340_04578	1.369e-62	222.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DYD2_k127_4894684_2	351607.Acel_0516	5.678e-74	273.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria,4EXC4@85013|Frankiales	201174|Actinobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	devS	GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07682	ko02020,map02020	M00482	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HATPase_c_2,HisKA_3
DYD2_k127_4894684_1	1385520.N802_02245	2.938e-82	287.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4FEPZ@85021|Intrasporangiaceae	201174|Actinobacteria	I	Dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_4900511_2	1382356.JQMP01000003_gene2542	7.048e-127	418.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi,27XRP@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DYD2_k127_4900511_1	1380356.JNIK01000004_gene129	2.13e-130	428.0	COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria,4ERDN@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
DYD2_k127_4900511_4	1160718.SU9_18498	6.312e-57	211.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DYD2_k127_4900511_5	298653.Franean1_5899	2.665e-54	201.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4ERZQ@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133,5.1.3.13	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
DYD2_k127_4900511_0	1179773.BN6_57850	3.368e-143	460.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4E22V@85010|Pseudonocardiales	201174|Actinobacteria	M	GDP-mannose 4,6 dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
DYD2_k127_4900511_3	28444.JODQ01000018_gene7288	1.057e-97	329.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4EFVB@85012|Streptosporangiales	201174|Actinobacteria	M	Nucleotidyl transferase	strD	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DYD2_k127_4935008_2	1128421.JAGA01000003_gene2765	2.337e-08	61.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_4935008_0	1128421.JAGA01000003_gene2765	2.325e-53	205.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_4935008_1	1120949.KB903294_gene3899	4.502e-41	169.0	COG2936@1|root,COG2936@2|Bacteria,2GJ2K@201174|Actinobacteria,4DC1G@85008|Micromonosporales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	pepX	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_4936900_0	68219.JNXI01000002_gene3946	3.831e-82	284.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
DYD2_k127_4936900_1	203119.Cthe_3199	2.93e-38	157.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,3WN23@541000|Ruminococcaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
DYD2_k127_4955102_4	58123.JOFJ01000006_gene105	6.806e-23	102.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4EH9Z@85012|Streptosporangiales	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
DYD2_k127_4955102_3	1496688.ER33_06230	3.902e-37	145.0	COG3453@1|root,COG3453@2|Bacteria,1G6UU@1117|Cyanobacteria	1117|Cyanobacteria	S	phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
DYD2_k127_4955102_2	1122921.KB898187_gene4510	6.843e-38	151.0	COG2318@1|root,COG2318@2|Bacteria,1VM9M@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
DYD2_k127_4955102_1	477641.MODMU_1730	1.663e-109	362.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4ETQ9@85013|Frankiales	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
DYD2_k127_4955102_6	479434.Sthe_0370	1.636e-05	57.0	2DW90@1|root,33Z49@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1706)	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4955102_0	469371.Tbis_2456	3.72e-160	520.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4DZ1E@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2427c	Aldedh
DYD2_k127_4955102_5	1401064.HMPREF2129_06220	9.301e-14	73.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,22KVR@1653|Corynebacteriaceae	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
DYD2_k127_4966751_2	67352.JODS01000021_gene3805	4.134e-77	268.0	COG0477@1|root,COG0477@2|Bacteria,2GKFJ@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_3
DYD2_k127_4966751_1	1238182.C882_1307	1.163e-116	381.0	COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,2JT9Q@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
DYD2_k127_4966751_5	1121923.GPUN_0885	1.183e-08	63.0	COG1403@1|root,COG1403@2|Bacteria,1PF6V@1224|Proteobacteria,1SIBH@1236|Gammaproteobacteria,46C0I@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
DYD2_k127_4966751_0	43354.JOIJ01000005_gene2299	3.846e-129	425.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4DYE8@85010|Pseudonocardiales	201174|Actinobacteria	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
DYD2_k127_4966751_4	2045.KR76_15770	1.473e-26	116.0	COG1595@1|root,COG1595@2|Bacteria,2GP81@201174|Actinobacteria,4DRAR@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	sigE	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_4966751_3	68194.JNXR01000006_gene3675	6.937e-36	140.0	2DBVK@1|root,2ZBBH@2|Bacteria,2H5Z5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4970044_4	1150864.MILUP08_46746	7.344e-51	191.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria,4DD6R@85008|Micromonosporales	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
DYD2_k127_4970044_6	1150398.JIBJ01000002_gene1062	1.009e-09	69.0	COG0586@1|root,COG0586@2|Bacteria,2IA3P@201174|Actinobacteria	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DYD2_k127_4970044_1	298653.Franean1_1858	8.569e-109	371.0	COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2GM2U@201174|Actinobacteria,4ES4W@85013|Frankiales	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
DYD2_k127_4970044_0	469383.Cwoe_4727	8.286e-114	380.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CRSZ@84995|Rubrobacteria	84995|Rubrobacteria	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
DYD2_k127_4970044_5	864702.OsccyDRAFT_4243	9.498e-39	156.0	COG4191@1|root,COG4191@2|Bacteria,1G5TB@1117|Cyanobacteria,1HB2V@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4970044_2	2074.JNYD01000042_gene2208	1.735e-86	313.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria,4DZ97@85010|Pseudonocardiales	201174|Actinobacteria	T	Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c_2,SpoIIE
DYD2_k127_4970044_7	1068978.AMETH_1274	1.913e-08	63.0	COG1366@1|root,COG1366@2|Bacteria,2GQY5@201174|Actinobacteria,4E6VT@85010|Pseudonocardiales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS,STAS_2
DYD2_k127_4970044_3	1229780.BN381_90064	1.496e-58	208.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,3UX2T@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Molybdenum Cofactor Synthesis C	moaA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
DYD2_k127_4991083_2	37919.EP51_18215	1.18e-13	73.0	COG3620@1|root,COG3620@2|Bacteria,2GTMF@201174|Actinobacteria,4G46P@85025|Nocardiaceae	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
DYD2_k127_4991083_1	2074.JNYD01000016_gene4234	4.446e-37	143.0	2A6ZD@1|root,30VUF@2|Bacteria,2HA63@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4991083_0	196162.Noca_3341	1.963e-64	225.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
DYD2_k127_4994168_1	1968.JOEV01000044_gene2219	3.652e-28	123.0	COG1547@1|root,COG1547@2|Bacteria,2IHUS@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
DYD2_k127_4994168_3	1184607.AUCHE_05_05450	1.825e-08	62.0	COG2867@1|root,COG2867@2|Bacteria,2IIBS@201174|Actinobacteria	201174|Actinobacteria	I	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4994168_2	1379698.RBG1_1C00001G0843	1.723e-23	111.0	COG1011@1|root,COG1011@2|Bacteria,2NQ1K@2323|unclassified Bacteria	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
DYD2_k127_4994168_0	711393.AYRX01000022_gene1161	7.705e-34	136.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria	201174|Actinobacteria	I	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
DYD2_k127_5033720_3	511062.GU3_06290	9.718e-14	77.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Membrane-bound serine protease (ClpP class)	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
DYD2_k127_5033720_1	926569.ANT_29010	2.337e-96	323.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi	200795|Chloroflexi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DYD2_k127_5033720_2	387093.SUN_0927	1.39e-42	164.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42RKH@68525|delta/epsilon subdivisions	1224|Proteobacteria	Q	PFAM isochorismatase hydrolase	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
DYD2_k127_5033720_0	367299.JOEE01000004_gene1091	8.196e-147	471.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4FFIE@85021|Intrasporangiaceae	201174|Actinobacteria	E	Acetolactate synthase	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DYD2_k127_505538_2	338966.Ppro_3066	4.764e-72	255.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,43UB6@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
DYD2_k127_505538_0	264732.Moth_2052	2.886e-143	467.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,42FJ7@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
DYD2_k127_505538_3	298653.Franean1_0207	9.014e-43	163.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4ESMK@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
DYD2_k127_505538_1	582899.Hden_2591	1.238e-72	251.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,3N6I7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
DYD2_k127_5057244_1	596151.DesfrDRAFT_2590	3.72e-45	174.0	COG0279@1|root,COG2605@1|root,COG0279@2|Bacteria,COG2605@2|Bacteria,1QWU7@1224|Proteobacteria,42QI3@68525|delta/epsilon subdivisions,2X8DE@28221|Deltaproteobacteria,2MGSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,SIS_2
DYD2_k127_5057244_3	926569.ANT_19990	1.102e-05	49.0	COG2605@1|root,COG2605@2|Bacteria,2G5TF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM GHMP kinase	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DYD2_k127_5057244_2	383372.Rcas_0448	2.927e-38	151.0	COG0241@1|root,COG0241@2|Bacteria,2G6V8@200795|Chloroflexi,375WG@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM histidinol-phosphate phosphatase family protein	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
DYD2_k127_5057244_0	237368.SCABRO_02713	3.668e-47	179.0	COG0279@1|root,COG0279@2|Bacteria,2IZ19@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoheptose isomerase	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
DYD2_k127_5066202_5	1183438.GKIL_3498	2.447e-22	105.0	COG4552@1|root,COG4552@2|Bacteria,1G1E1@1117|Cyanobacteria	1117|Cyanobacteria	S	acetyltransferase involved in intracellular survival and related	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
DYD2_k127_5066202_7	935548.KI912159_gene6126	2.413e-08	64.0	COG4454@1|root,COG4454@2|Bacteria,1N1PE@1224|Proteobacteria,2UCWF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SoxE
DYD2_k127_5066202_2	1123389.ATXJ01000002_gene1559	1.136e-82	286.0	COG0136@1|root,COG0136@2|Bacteria,1WIMU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DYD2_k127_5066202_1	1121877.JQKF01000011_gene381	4.037e-142	469.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CMX1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
DYD2_k127_5066202_3	66874.JOFS01000049_gene3200	3.561e-42	173.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_5066202_4	196162.Noca_4889	2.444e-36	141.0	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria	2|Bacteria	S	DsrE/DsrF-like family	-	-	-	ko:K06039,ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE
DYD2_k127_5066202_0	1394178.AWOO02000016_gene6866	6.169e-219	691.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG41@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
DYD2_k127_5066202_6	134676.ACPL_4389	5.405e-10	62.0	COG2306@1|root,COG2306@2|Bacteria,2GJP9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF402
DYD2_k127_5078571_0	1278073.MYSTI_01001	4.247e-32	128.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2YUFW@29|Myxococcales	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
DYD2_k127_5105294_2	215803.DB30_1747	3.948e-34	149.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	MA20_04930	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_5105294_1	512565.AMIS_71480	1.369e-180	583.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DA3Q@85008|Micromonosporales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DYD2_k127_5105294_0	219305.MCAG_01071	4.173e-188	611.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4D8JC@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DYD2_k127_5125066_2	1449049.JONW01000005_gene1128	3.701e-26	123.0	COG0613@1|root,COG0613@2|Bacteria,1MXJ5@1224|Proteobacteria,2U1RY@28211|Alphaproteobacteria,2KF71@204458|Caulobacterales	204458|Caulobacterales	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5125066_0	1463825.JNXC01000002_gene4477	8.691e-109	358.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4DYS9@85010|Pseudonocardiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DYD2_k127_5125066_1	446462.Amir_1477	2.95e-96	320.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DXJD@85010|Pseudonocardiales	201174|Actinobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DYD2_k127_5130809_2	1286171.EAL2_808p04380	3.499e-21	105.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,25VZ9@186806|Eubacteriaceae	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
DYD2_k127_5130809_1	882082.SaccyDRAFT_0967	1.356e-38	167.0	KOG2232@1|root,2Z84X@2|Bacteria,2GS3B@201174|Actinobacteria,4DZG2@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Neutral alkaline non-lysosomal ceramidase	-	GO:0001676,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006665,GO:0006670,GO:0006672,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009987,GO:0016042,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0017040,GO:0019751,GO:0019752,GO:0030148,GO:0030149,GO:0030312,GO:0032787,GO:0034311,GO:0034312,GO:0034641,GO:0042759,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046165,GO:0046173,GO:0046394,GO:0046466,GO:0046467,GO:0046512,GO:0046514,GO:0046519,GO:0046520,GO:0071704,GO:0071944,GO:0072330,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901617	3.5.1.23	ko:K12349	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00099	R01494	RC00064,RC00328	ko00000,ko00001,ko00002,ko01000	-	-	-	Ceramidase_alk,Ceramidse_alk_C
DYD2_k127_5130809_0	936455.KI421499_gene2446	6.666e-81	286.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TWR2@28211|Alphaproteobacteria,3JVDD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_5130809_3	208439.AJAP_16315	7.444e-12	70.0	COG0346@1|root,COG0346@2|Bacteria,2IM7G@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
DYD2_k127_5148990_10	760568.Desku_2105	2.515e-27	125.0	COG1404@1|root,COG3934@1|root,COG4733@1|root,COG1404@2|Bacteria,COG3934@2|Bacteria,COG4733@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,260VW@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651,ko:K13274,ko:K13276,ko:K13277	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
DYD2_k127_5148990_4	1206101.AZXC01000015_gene4987	4.708e-67	243.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria	201174|Actinobacteria	FP	Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
DYD2_k127_5148990_8	1205910.B005_2861	3.486e-46	173.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4EIPC@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
DYD2_k127_5148990_9	1308866.J416_04526	1.294e-28	119.0	COG1098@1|root,COG1098@2|Bacteria,1V6FE@1239|Firmicutes,4HIKM@91061|Bacilli,470XK@74385|Gracilibacillus	91061|Bacilli	J	Ribosomal protein S1-like RNA-binding domain	yabR	-	-	ko:K07571	-	-	-	-	ko00000	-	-	-	S1
DYD2_k127_5148990_13	643648.Slip_0117	0.0003791	49.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
DYD2_k127_5148990_0	349161.Dred_2987	3.169e-178	567.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,2600A@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DYD2_k127_5148990_3	926560.KE387026_gene4276	1.167e-70	249.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
DYD2_k127_5148990_2	867903.ThesuDRAFT_00861	3.036e-101	342.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WCSJ@538999|Clostridiales incertae sedis	186801|Clostridia	P	Carbohydrate ABC transporter ATP-binding protein, CUT1 family	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
DYD2_k127_5148990_1	1313172.YM304_07580	5.296e-116	387.0	COG1653@1|root,COG1653@2|Bacteria,2HFKE@201174|Actinobacteria,4CP2S@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
DYD2_k127_5148990_5	1136417.AZWE01000028_gene2558	5.577e-62	223.0	COG0395@1|root,COG0395@2|Bacteria,2IPUK@201174|Actinobacteria,4DER9@85008|Micromonosporales	201174|Actinobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
DYD2_k127_5148990_7	1120958.AULD01000006_gene519	3.142e-55	207.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4FNXD@85023|Microbacteriaceae	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
DYD2_k127_5148990_12	765912.Thimo_0436	6.572e-14	83.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales	135613|Chromatiales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
DYD2_k127_5148990_6	1184609.KILIM_001_00290	1.41e-61	219.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4F616@85018|Dermatophilaceae	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
DYD2_k127_5162486_2	1121920.AUAU01000011_gene197	1.204e-43	164.0	COG1372@1|root,COG1573@1|root,COG1372@2|Bacteria,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DYD2_k127_5162486_1	561175.KB894093_gene4300	2.231e-45	178.0	COG2267@1|root,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria,4EFMQ@85012|Streptosporangiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
DYD2_k127_5162486_0	760568.Desku_1293	5.064e-92	317.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
DYD2_k127_5162486_3	1382358.JHVN01000006_gene160	5.829e-11	66.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,4HBZC@91061|Bacilli,21WX0@150247|Anoxybacillus	91061|Bacilli	G	YjeF-related protein N-terminus	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
DYD2_k127_5170954_3	58344.JOEL01000016_gene5915	3.284e-05	48.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_5170954_0	469371.Tbis_1326	3.796e-143	461.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4DXGU@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DYD2_k127_5170954_1	656024.FsymDg_0477	1.077e-20	102.0	2E1PK@1|root,32X02@2|Bacteria,2GUS8@201174|Actinobacteria,4EWBT@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF1353
DYD2_k127_5170954_2	329726.AM1_4443	4.761e-06	53.0	2DS32@1|root,33EAN@2|Bacteria	2|Bacteria	S	Tissue inhibitor of metalloproteinase	-	-	-	-	-	-	-	-	-	-	-	-	TIMP
DYD2_k127_5220786_10	1283283.ATXA01000002_gene2533	1.591e-32	128.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4ERQC@85013|Frankiales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
DYD2_k127_5220786_0	756499.Desde_3246	2.038e-148	488.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,2610F@186807|Peptococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
DYD2_k127_5220786_3	67275.JOAP01000007_gene4333	8.106e-59	211.0	COG4894@1|root,COG4894@2|Bacteria,2GMU8@201174|Actinobacteria	201174|Actinobacteria	S	Scramblase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,Scramblase
DYD2_k127_5220786_11	891968.Anamo_1553	5.919e-32	126.0	COG0228@1|root,COG0228@2|Bacteria,3TBDH@508458|Synergistetes	508458|Synergistetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
DYD2_k127_5220786_13	223184.AS25_09150	6.245e-14	77.0	COG1837@1|root,COG1837@2|Bacteria,2IQ4C@201174|Actinobacteria,1W9RJ@1268|Micrococcaceae	201174|Actinobacteria	S	Belongs to the UPF0109 family	-	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
DYD2_k127_5220786_8	1150864.MILUP08_41482	5.512e-38	153.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4DD1W@85008|Micromonosporales	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
DYD2_k127_5220786_2	118173.KB235914_gene4032	2.678e-76	269.0	COG0336@1|root,COG0336@2|Bacteria,1G0C1@1117|Cyanobacteria,1H7SD@1150|Oscillatoriales	1117|Cyanobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228,4.6.1.12	ko:K00554,ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	YgbB,tRNA_m1G_MT
DYD2_k127_5220786_6	1294265.JCM21738_272	1.79e-44	169.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,1ZGDK@1386|Bacillus	91061|Bacilli	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
DYD2_k127_5220786_5	477641.MODMU_4414	2.542e-45	175.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4ESKU@85013|Frankiales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
DYD2_k127_5220786_7	298653.Franean1_1153	2.552e-41	167.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4ESKU@85013|Frankiales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
DYD2_k127_5220786_4	446470.Snas_2189	1.978e-56	206.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4EYH1@85014|Glycomycetales	201174|Actinobacteria	L	Ribonuclease HII	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
DYD2_k127_5220786_9	1176165.CAJD01000013_gene806	1.257e-36	141.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4FA03@85019|Brevibacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
DYD2_k127_5220786_12	593907.Celgi_2104	1.901e-21	98.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4F2QP@85016|Cellulomonadaceae	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
DYD2_k127_5220786_1	197221.22294316	2.423e-124	409.0	COG0606@1|root,COG0606@2|Bacteria,1G0K1@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM Magnesium chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
DYD2_k127_5228139_0	767029.HMPREF9154_0546	1.536e-67	243.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2GKDT@201174|Actinobacteria,4DPGX@85009|Propionibacteriales	201174|Actinobacteria	CO	Thioredoxin-like	dipZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD
DYD2_k127_5230284_1	1463858.JOHR01000014_gene5107	1.125e-19	91.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	mcl1	-	4.1.3.34,5.4.99.63	ko:K01644,ko:K14447	ko00630,ko01120,ko01200,ko02020,map00630,map01120,map01200,map02020	M00373	R00362,R09292	RC00067,RC01118,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
DYD2_k127_5230284_0	266117.Rxyl_1110	3.39e-157	506.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4CPBI@84995|Rubrobacteria	84995|Rubrobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
DYD2_k127_5249906_0	675635.Psed_1710	1.255e-40	155.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4DX5C@85010|Pseudonocardiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_5249906_1	222534.KB893711_gene5005	2.531e-18	90.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4ERSX@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	pimB	GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_5254178_0	1229780.BN381_10093	4.296e-43	165.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,3UWA6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
DYD2_k127_5264979_0	351607.Acel_1508	4.472e-126	414.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4ERV5@85013|Frankiales	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
DYD2_k127_5264979_4	1150599.MPHLEI_08239	2.813e-31	127.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,239X2@1762|Mycobacteriaceae	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
DYD2_k127_5264979_6	267608.RSp1180	0.0008031	52.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VNQS@28216|Betaproteobacteria,1K4ZC@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3,HemolysinCabind
DYD2_k127_5264979_2	1123024.AUII01000001_gene2869	7.934e-82	282.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4DZQA@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
DYD2_k127_5264979_3	43354.JOIJ01000002_gene4397	8.989e-73	254.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4DZ6C@85010|Pseudonocardiales	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
DYD2_k127_5264979_1	2002.JOEQ01000001_gene4822	4.042e-96	325.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4EHHU@85012|Streptosporangiales	201174|Actinobacteria	S	DHH family	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
DYD2_k127_5264979_5	796942.HMPREF9623_00241	0.0003431	49.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
DYD2_k127_5274170_3	469383.Cwoe_4154	1.467e-31	134.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,2I8FG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5274170_0	222534.KB893670_gene3828	2.688e-89	304.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria,4ES37@85013|Frankiales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
DYD2_k127_5274170_1	285535.JOEY01000016_gene3479	1.426e-74	257.0	COG1309@1|root,COG1309@2|Bacteria,2GMBW@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	icaR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DYD2_k127_5274170_2	525904.Tter_2415	1.579e-61	220.0	COG2843@1|root,COG2843@2|Bacteria	2|Bacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	CarboxypepD_reg,PGA_cap,Peptidase_M15_4
DYD2_k127_5335484_1	66429.JOFL01000016_gene40	2.737e-35	155.0	COG2936@1|root,COG2936@2|Bacteria,2GJ2K@201174|Actinobacteria	201174|Actinobacteria	E	dipeptidyl-peptidase	pepX	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_5335484_0	1313172.YM304_09460	6.067e-97	328.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4CNZW@84992|Acidimicrobiia	201174|Actinobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
DYD2_k127_5336659_0	436229.JOEH01000006_gene2934	3.351e-127	434.0	COG4585@1|root,COG4585@2|Bacteria,2GMMU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
DYD2_k127_5336659_1	675635.Psed_3522	4.447e-36	140.0	COG2197@1|root,COG2197@2|Bacteria,2INZX@201174|Actinobacteria	201174|Actinobacteria	T	Pfam Response regulator receiver	-	-	-	ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
DYD2_k127_5356996_0	443144.GM21_4054	4.182e-42	165.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions	1224|Proteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
DYD2_k127_5356996_1	1232410.KI421428_gene1086	1.286e-29	128.0	COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,42R2M@68525|delta/epsilon subdivisions,2WMWP@28221|Deltaproteobacteria,43SFC@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT,ACT_6
DYD2_k127_5356996_2	1397528.Q671_09895	1.315e-14	78.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,1SB4C@1236|Gammaproteobacteria,1XQ58@135619|Oceanospirillales	135619|Oceanospirillales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
DYD2_k127_5366431_3	319795.Dgeo_1916	1.865e-30	128.0	COG3396@1|root,COG3396@2|Bacteria,1WI5D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM Phenylacetate-CoA oxygenase, PaaI subunit	paaC	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
DYD2_k127_5366431_5	1120972.AUMH01000001_gene1174	2.885e-07	58.0	COG3460@1|root,COG3460@2|Bacteria,1V6J5@1239|Firmicutes,4HM2N@91061|Bacilli,27A6Q@186823|Alicyclobacillaceae	91061|Bacilli	Q	Phenylacetic acid degradation B	-	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
DYD2_k127_5366431_0	869210.Marky_1366	1.152e-125	409.0	COG3396@1|root,COG3396@2|Bacteria,1WI17@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
DYD2_k127_5366431_1	867903.ThesuDRAFT_00737	9.734e-74	263.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,24HM8@186801|Clostridia,3WDT7@538999|Clostridiales incertae sedis	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_5366431_4	882083.SacmaDRAFT_5179	7.807e-12	69.0	COG3224@1|root,COG3224@2|Bacteria,2GQKQ@201174|Actinobacteria,4E6EH@85010|Pseudonocardiales	201174|Actinobacteria	S	EthD domain	-	-	-	-	-	-	-	-	-	-	-	-	EthD
DYD2_k127_5366431_2	1120936.KB907210_gene5885	2.276e-58	215.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4EHZN@85012|Streptosporangiales	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
DYD2_k127_5371700_3	543632.JOJL01000037_gene6377	6.814e-10	60.0	COG0566@1|root,COG0566@2|Bacteria,2GM1A@201174|Actinobacteria,4DB7B@85008|Micromonosporales	201174|Actinobacteria	J	tRNA rRNA methyltransferase	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
DYD2_k127_5371700_2	4555.Si005184m	1.182e-14	86.0	arCOG05967@1|root,2QSXK@2759|Eukaryota,37JS6@33090|Viridiplantae,3GBKD@35493|Streptophyta,3KTX3@4447|Liliopsida,3IFU9@38820|Poales	35493|Streptophyta	S	Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A	-	-	-	-	-	-	-	-	-	-	-	-	PNGaseA
DYD2_k127_5371700_0	1223545.GS4_37_00030	7.201e-42	162.0	COG0537@1|root,COG0537@2|Bacteria,2IKWU@201174|Actinobacteria,4GDYM@85026|Gordoniaceae	201174|Actinobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
DYD2_k127_5371700_1	298655.KI912266_gene5070	1.432e-31	138.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
DYD2_k127_5378480_1	2074.JNYD01000019_gene2459	1.686e-55	206.0	COG2141@1|root,COG2141@2|Bacteria,2GN4N@201174|Actinobacteria,4E0Y2@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_5378480_2	867845.KI911784_gene2352	6.638e-43	166.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,375NK@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
DYD2_k127_5378480_0	1120936.KB907223_gene2453	3.599e-58	228.0	COG1506@1|root,COG1506@2|Bacteria,2I5V8@201174|Actinobacteria,4ER80@85012|Streptosporangiales	201174|Actinobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	Peptidase_S15
DYD2_k127_5386808_3	525904.Tter_2031	1.494e-14	79.0	2ESUF@1|root,33KCV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5386808_1	1169161.KB897726_gene1525	1.705e-21	104.0	COG1633@1|root,COG1633@2|Bacteria,2I2E1@201174|Actinobacteria	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
DYD2_k127_5386808_0	1089553.Tph_c06550	2.246e-45	183.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,42FSF@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Peptidase M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
DYD2_k127_5386808_2	1307834.BARL01000005_gene2669	1.182e-19	91.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2JPGY@204441|Rhodospirillales	204441|Rhodospirillales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
DYD2_k127_5394663_1	875328.JDM601_1418	5.28e-99	334.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,234HF@1762|Mycobacteriaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
DYD2_k127_5394663_4	547163.BN979_03911	0.0002146	51.0	COG2856@1|root,COG2856@2|Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_M78
DYD2_k127_5394663_0	1267535.KB906767_gene4059	2.742e-127	422.0	COG0677@1|root,COG0677@2|Bacteria,3Y30B@57723|Acidobacteria,2JIIN@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DYD2_k127_5394663_2	1121468.AUBR01000058_gene875	2.069e-94	320.0	COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,24ETR@186801|Clostridia,42FP9@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	ldh	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DYD2_k127_5394663_3	1283283.ATXA01000023_gene236	3.215e-23	100.0	COG2452@1|root,COG2452@2|Bacteria,2GQJ9@201174|Actinobacteria	201174|Actinobacteria	L	TIGRFAM DNA binding domain protein, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DYD2_k127_5411878_2	471852.Tcur_4797	5.419e-46	185.0	COG1506@1|root,COG1506@2|Bacteria,2I5V8@201174|Actinobacteria,4ER80@85012|Streptosporangiales	201174|Actinobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	Peptidase_S15
DYD2_k127_5411878_0	42256.RradSPS_1289	8.448e-92	310.0	COG0003@1|root,COG0003@2|Bacteria,2GISZ@201174|Actinobacteria,4CPDY@84995|Rubrobacteria	84995|Rubrobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
DYD2_k127_5411878_5	768706.Desor_2782	9.957e-31	124.0	COG0003@1|root,COG0071@1|root,COG0003@2|Bacteria,COG0071@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,260AD@186807|Peptococcaceae	186801|Clostridia	OP	TIGRFAM arsenite-activated ATPase ArsA	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
DYD2_k127_5411878_1	478801.Ksed_16120	6.606e-73	255.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,1ZWC6@145357|Dermacoccaceae	201174|Actinobacteria	GK	ROK family	glkA	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
DYD2_k127_5411878_3	1168065.DOK_17735	1.604e-41	166.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,DUF2048,Peptidase_S9
DYD2_k127_5411878_4	1370120.AUWR01000040_gene65	9.207e-40	156.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,232VV@1762|Mycobacteriaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DYD2_k127_541871_3	479433.Caci_5608	9.463e-20	88.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
DYD2_k127_541871_1	1380390.JIAT01000015_gene5680	1.574e-118	392.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4CPN6@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
DYD2_k127_541871_2	1229780.BN381_80403	1.442e-93	313.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,3UWH0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
DYD2_k127_541871_0	247490.KSU1_C0456	8.359e-124	412.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
DYD2_k127_541871_4	492774.JQMB01000003_gene2496	2.837e-10	72.0	COG0747@1|root,COG0747@2|Bacteria,1N5F5@1224|Proteobacteria,2U19W@28211|Alphaproteobacteria,4BDF8@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13889	ko02010,map02010	M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.11	-	-	SBP_bac_5
DYD2_k127_5429307_8	1385518.N798_14415	5.132e-58	208.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4FFW9@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
DYD2_k127_5429307_0	1121422.AUMW01000014_gene1329	7.795e-165	526.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,2602X@186807|Peptococcaceae	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_5429307_9	656024.FsymDg_2816	4.937e-55	208.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4ERZA@85013|Frankiales	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
DYD2_k127_5429307_2	1907.SGLAU_08135	1.222e-132	450.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
DYD2_k127_5429307_1	1380387.JADM01000004_gene2815	5.242e-163	529.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria,1XIZK@135619|Oceanospirillales	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	aidB	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_5429307_6	1123320.KB889675_gene3796	4.188e-65	228.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
DYD2_k127_5429307_7	44060.JODL01000003_gene2814	1.512e-61	229.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Extracellular ligand-binding receptor	braC	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DYD2_k127_5429307_4	469371.Tbis_1470	3.149e-93	315.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4DYKY@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DYD2_k127_5429307_5	457429.ABJI02000622_gene4120	1.316e-80	286.0	COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
DYD2_k127_5429307_3	1120936.KB907210_gene5644	5.714e-95	318.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4EIB3@85012|Streptosporangiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DYD2_k127_5429307_10	1449355.JQNR01000003_gene162	2.549e-51	186.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DYD2_k127_5430171_4	479435.Kfla_1524	2.8e-64	229.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DQ5C@85009|Propionibacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DYD2_k127_5430171_9	1121378.KB899748_gene3513	1.797e-10	64.0	COG0025@1|root,COG0025@2|Bacteria	2|Bacteria	P	sodium:proton antiporter activity	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
DYD2_k127_5430171_10	33876.JNXY01000037_gene8039	2.315e-10	70.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4DGT4@85008|Micromonosporales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
DYD2_k127_5430171_8	33876.JNXY01000039_gene6634	5.834e-17	91.0	COG4965@1|root,COG4965@2|Bacteria,2H577@201174|Actinobacteria,4DIW9@85008|Micromonosporales	201174|Actinobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
DYD2_k127_5430171_1	743718.Isova_0098	1.48e-102	347.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4F59S@85017|Promicromonosporaceae	201174|Actinobacteria	U	Type II/IV secretion system protein	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DYD2_k127_5430171_11	1172186.KB911465_gene4509	8.65e-08	63.0	COG0455@1|root,COG0455@2|Bacteria,2GIVN@201174|Actinobacteria,2340I@1762|Mycobacteriaceae	201174|Actinobacteria	D	bacterial-type flagellum organization	cpaE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CbiA
DYD2_k127_5430171_6	1472716.KBK24_0132785	1.438e-39	160.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2VHCH@28216|Betaproteobacteria,1JZUF@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DYD2_k127_5430171_5	266117.Rxyl_1743	5.914e-56	209.0	COG0842@1|root,COG0842@2|Bacteria,2IPQ3@201174|Actinobacteria,4CT8V@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DYD2_k127_5430171_2	1283299.AUKG01000002_gene5111	6.391e-96	327.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4CP6S@84995|Rubrobacteria	84995|Rubrobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DYD2_k127_5430171_7	929712.KI912613_gene2704	3.725e-21	102.0	COG1309@1|root,COG1309@2|Bacteria,2GWF1@201174|Actinobacteria,4CQGJ@84995|Rubrobacteria	84995|Rubrobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DYD2_k127_5430171_3	1048339.KB913029_gene1205	4.406e-85	296.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4ERXM@85013|Frankiales	201174|Actinobacteria	E	haloacid dehalogenase-like hydrolase	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
DYD2_k127_5430171_0	502025.Hoch_4258	8.466e-193	623.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,437TW@68525|delta/epsilon subdivisions,2X33B@28221|Deltaproteobacteria,2YU23@29|Myxococcales	28221|Deltaproteobacteria	EU	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
DYD2_k127_544373_1	211114.JOEF01000031_gene1877	1.632e-46	177.0	COG1309@1|root,COG1309@2|Bacteria,2I0Y2@201174|Actinobacteria,4E2PJ@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DYD2_k127_544373_5	1037409.BJ6T_21430	3.108e-26	118.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,3JR1Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	MA20_04530	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DYD2_k127_544373_0	2002.JOEQ01000005_gene3813	7.194e-201	646.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG8G@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
DYD2_k127_544373_2	927677.ALVU02000001_gene1908	1.384e-42	179.0	COG2211@1|root,COG2211@2|Bacteria,1G0JI@1117|Cyanobacteria,1H578@1142|Synechocystis	1117|Cyanobacteria	G	PUCC protein	pucC	-	-	ko:K08226	-	-	-	-	ko00000,ko02000	2.A.1.41	-	-	PUCC
DYD2_k127_544373_4	1229780.BN381_10243	3.397e-34	152.0	COG0410@1|root,COG0411@1|root,COG0410@2|Bacteria,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
DYD2_k127_544373_3	1048339.KB913029_gene1969	2.178e-41	169.0	COG0410@1|root,COG0411@1|root,COG0410@2|Bacteria,COG0411@2|Bacteria,2H3P9@201174|Actinobacteria,4EXEI@85013|Frankiales	201174|Actinobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
DYD2_k127_5444655_3	1379698.RBG1_1C00001G1061	3.308e-96	321.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
DYD2_k127_5444655_1	1210045.ALNP01000026_gene743	3.467e-109	372.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
DYD2_k127_5444655_5	298654.FraEuI1c_6260	1.058e-76	268.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4ERU8@85013|Frankiales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
DYD2_k127_5444655_0	326427.Cagg_1972	4.788e-121	398.0	COG0381@1|root,COG0381@2|Bacteria,2G7S6@200795|Chloroflexi,375NM@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.23	ko:K13019	ko00520,map00520	-	R09600	RC00290	ko00000,ko00001,ko01000,ko01005	-	-	-	Epimerase_2
DYD2_k127_5444655_6	408672.NBCG_05255	1.885e-52	198.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,4DQG8@85009|Propionibacteriales	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	wbpD	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
DYD2_k127_5444655_2	304371.MCP_0764	8.357e-97	329.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,2N9FX@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
DYD2_k127_5444655_4	1382306.JNIM01000001_gene1459	6.979e-96	324.0	COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi	200795|Chloroflexi	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DYD2_k127_5447897_1	562970.Btus_2368	1.734e-75	256.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,278TC@186823|Alicyclobacillaceae	91061|Bacilli	C	Citrate synthase, C-terminal domain	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
DYD2_k127_5447897_2	349161.Dred_0447	1.196e-17	94.0	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,25ESC@186801|Clostridia,267BX@186807|Peptococcaceae	186801|Clostridia	S	pfam cbs	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DYD2_k127_5447897_0	1110697.NCAST_34_01140	2.016e-124	406.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4FU82@85025|Nocardiaceae	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
DYD2_k127_5447897_3	1146883.BLASA_0999	3.656e-15	85.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD
DYD2_k127_5451600_0	795797.C497_02257	7.11e-14	75.0	COG2936@1|root,arCOG07590@2157|Archaea	2157|Archaea	S	acyl esterases	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_5451600_1	317619.ANKN01000034_gene2499	3.047e-06	55.0	COG2402@1|root,COG2402@2|Bacteria,1G7CA@1117|Cyanobacteria	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_5451600_2	1312954.KI914868_gene141	2.3e-05	51.0	2CFSP@1|root,31CCI@2|Bacteria,2IFDM@201174|Actinobacteria,1WBDK@1268|Micrococcaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
DYD2_k127_5501394_1	351607.Acel_0417	5.754e-63	240.0	COG3858@1|root,COG5479@1|root,COG3858@2|Bacteria,COG5479@2|Bacteria,2GNDB@201174|Actinobacteria,4ESE3@85013|Frankiales	201174|Actinobacteria	M	Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme.	csp	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LGFP
DYD2_k127_5501394_0	246194.CHY_2199	7.284e-89	305.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
DYD2_k127_5501394_2	1128421.JAGA01000003_gene2765	6.173e-18	95.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_5513314_3	1394178.AWOO02000057_gene731	5.002e-17	91.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4EFVQ@85012|Streptosporangiales	201174|Actinobacteria	O	Trypsin-like peptidase domain	sprI	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
DYD2_k127_5513314_2	748247.AZKH_2969	1.92e-68	239.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2VJ9S@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
DYD2_k127_5513314_4	883.DvMF_0607	5.564e-12	75.0	COG0454@1|root,COG0456@2|Bacteria,1NGUX@1224|Proteobacteria,43ADU@68525|delta/epsilon subdivisions,2X5TS@28221|Deltaproteobacteria,2MFAH@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5513314_1	1122611.KB903974_gene2885	1.401e-69	263.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4EHIV@85012|Streptosporangiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
DYD2_k127_5513314_0	487521.OCU_09290	6.85e-160	534.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,232ZK@1762|Mycobacteriaceae	201174|Actinobacteria	L	DNA ligase	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
DYD2_k127_5529943_3	765420.OSCT_2785	1.017e-56	206.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi,3750N@32061|Chloroflexia	32061|Chloroflexia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
DYD2_k127_5529943_2	1209989.TepiRe1_0932	5.086e-98	335.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia	186801|Clostridia	E	PFAM Cys Met metabolism	megL	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
DYD2_k127_5529943_1	463191.SSEG_08380	3.383e-102	344.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria	201174|Actinobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
DYD2_k127_5529943_5	65497.JODV01000001_gene3535	2.284e-41	161.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria,4DXRJ@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
DYD2_k127_5529943_6	679197.HMPREF9336_00683	3.497e-18	93.0	COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria	201174|Actinobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
DYD2_k127_5529943_10	1394178.AWOO02000025_gene5002	8.24e-11	64.0	COG1920@1|root,COG1920@2|Bacteria,2GQPF@201174|Actinobacteria,4EKJA@85012|Streptosporangiales	201174|Actinobacteria	S	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5529943_11	665571.STHERM_c06940	5.062e-07	57.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
DYD2_k127_5529943_7	404589.Anae109_2598	2.135e-16	85.0	COG0745@1|root,COG0745@2|Bacteria,1NBDV@1224|Proteobacteria,42UVC@68525|delta/epsilon subdivisions,2WQ45@28221|Deltaproteobacteria,2Z1WY@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_5529943_0	1048339.KB913029_gene3185	6.851e-149	491.0	COG2159@1|root,COG2159@2|Bacteria,2H94T@201174|Actinobacteria,4EWGY@85013|Frankiales	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5529943_9	1380390.JIAT01000009_gene991	9.902e-13	70.0	COG3794@1|root,COG3794@2|Bacteria,2HQ6D@201174|Actinobacteria,4CRPC@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5529943_4	1380390.JIAT01000009_gene991	5.742e-44	180.0	COG3794@1|root,COG3794@2|Bacteria,2HQ6D@201174|Actinobacteria,4CRPC@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5529943_8	1179773.BN6_42600	5.383e-16	89.0	COG1520@1|root,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria,4E0XU@85010|Pseudonocardiales	201174|Actinobacteria	S	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
DYD2_k127_5574938_0	68194.JNXR01000007_gene4205	1.41e-146	477.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
DYD2_k127_5574938_1	326427.Cagg_0670	6.25e-25	116.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	200795|Chloroflexi	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
DYD2_k127_559060_1	858619.CVAR_0203	1.847e-39	160.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,22JP8@1653|Corynebacteriaceae	201174|Actinobacteria	K	function transcriptional attenuator common domain protein	lytR2	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
DYD2_k127_559060_0	1449355.JQNR01000005_gene2198	3.484e-44	168.0	COG1607@1|root,COG1607@2|Bacteria,2GK6X@201174|Actinobacteria	201174|Actinobacteria	I	Acyl-CoA hydrolase	-	-	3.1.2.23	ko:K01075,ko:K10806	ko00130,ko00362,ko01040,ko01100,ko01110,ko01120,map00130,map00362,map01040,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
DYD2_k127_559060_3	29581.BW37_00870	0.0006267	51.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,2WBDI@28216|Betaproteobacteria,475K6@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
DYD2_k127_559060_2	1089552.KI911559_gene526	3.062e-13	70.0	COG2185@1|root,COG2185@2|Bacteria,1QU3N@1224|Proteobacteria,2TVY1@28211|Alphaproteobacteria,2JPZR@204441|Rhodospirillales	204441|Rhodospirillales	I	Methylmalonyl-CoA mutase	-	-	5.4.99.63	ko:K14447	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09292	RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
DYD2_k127_5594482_2	68194.JNXR01000010_gene5433	2.204e-46	174.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
DYD2_k127_5594482_1	1382306.JNIM01000001_gene533	2.948e-86	308.0	COG3173@1|root,COG3173@2|Bacteria,2G5RM@200795|Chloroflexi	200795|Chloroflexi	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
DYD2_k127_5594482_0	1027292.HMPREF9372_1142	2.806e-159	509.0	COG1960@1|root,COG1960@2|Bacteria,1UK89@1239|Firmicutes,4HAR5@91061|Bacilli,26CTP@186818|Planococcaceae	91061|Bacilli	I	Acyl-CoA dehydrogenase, middle domain	bbsG	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_5594786_11	741091.Rahaq_0060	2.348e-26	120.0	COG0454@1|root,COG0456@2|Bacteria,1N6BV@1224|Proteobacteria,1SAMT@1236|Gammaproteobacteria,3FF0F@34037|Rahnella	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_5594786_1	62928.azo2987	1.31e-54	198.0	COG0262@1|root,COG0262@2|Bacteria,1RH02@1224|Proteobacteria,2VQ3W@28216|Betaproteobacteria	28216|Betaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
DYD2_k127_5594786_10	296591.Bpro_4771	3.88e-31	125.0	2DQ44@1|root,334NC@2|Bacteria,1NCSR@1224|Proteobacteria,2VUY0@28216|Betaproteobacteria,4AF7Q@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
DYD2_k127_5594786_0	887898.HMPREF0551_1085	9.854e-81	274.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VUIT@28216|Betaproteobacteria,1KFF2@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
DYD2_k127_5594786_13	1123242.JH636434_gene5335	1.454e-20	95.0	COG3502@1|root,COG3502@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF952)	-	-	2.3.2.29,2.5.1.18,3.8.1.2	ko:K00799,ko:K01560,ko:K21420	ko00361,ko00480,ko00625,ko00980,ko00982,ko00983,ko01100,ko01120,ko01524,ko05200,ko05204,ko05225,ko05418,map00361,map00480,map00625,map00980,map00982,map00983,map01100,map01120,map01524,map05200,map05204,map05225,map05418	-	R03522,R05287,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11547,R11548,R11905	RC00004,RC00064,RC00069,RC00697,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	DUF952,GST_C_2,GST_N_3
DYD2_k127_5594786_7	525904.Tter_2726	5.136e-43	160.0	2EBEI@1|root,335F5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5594786_6	861299.J421_0147	1.519e-44	166.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
DYD2_k127_5594786_14	649638.Trad_1760	1.311e-13	80.0	29XYR@1|root,30JRD@2|Bacteria,1WNBY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
DYD2_k127_5594786_2	1120950.KB892831_gene5056	4.051e-52	195.0	COG3173@1|root,COG3173@2|Bacteria,2H16C@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	2.7.1.163	ko:K18817	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	APH
DYD2_k127_5594786_3	1303518.CCALI_02419	8.928e-52	204.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	remC	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_5594786_9	395019.Bmul_5443	5.141e-35	146.0	COG1216@1|root,COG1216@2|Bacteria,1MXMZ@1224|Proteobacteria,2VMGC@28216|Betaproteobacteria,1KII8@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Pfam Glycosyl transferase family 2	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_2_3,Glycos_transf_2
DYD2_k127_5594786_8	1121406.JAEX01000018_gene2811	6.433e-39	162.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,42WA6@68525|delta/epsilon subdivisions,2WRYV@28221|Deltaproteobacteria,2MD0F@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,SPASM
DYD2_k127_5594786_4	324602.Caur_0991	2.616e-49	192.0	COG0438@1|root,COG0438@2|Bacteria,2G5QJ@200795|Chloroflexi,3756M@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_5594786_5	479434.Sthe_0245	3.968e-49	192.0	COG0438@1|root,COG0438@2|Bacteria,2G6I1@200795|Chloroflexi,27XSJ@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
DYD2_k127_5594786_12	1283299.AUKG01000001_gene2264	4.18e-23	106.0	COG0438@1|root,COG0438@2|Bacteria,2IBSQ@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_5598008_3	1229172.JQFA01000002_gene4824	1.526e-32	145.0	COG2385@1|root,COG2385@2|Bacteria,1G2FP@1117|Cyanobacteria,1H8UJ@1150|Oscillatoriales	1117|Cyanobacteria	D	PFAM Stage II sporulation protein	spoIID	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
DYD2_k127_5598008_1	1536774.H70357_29815	6.009e-65	233.0	COG0697@1|root,COG0697@2|Bacteria,1UZ6C@1239|Firmicutes,4HKQT@91061|Bacilli,26WER@186822|Paenibacillaceae	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_5598008_0	1229780.BN381_310078	1.783e-121	400.0	COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,2GRHK@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_9,FrhB_FdhB_C,FrhB_FdhB_N
DYD2_k127_5598008_2	525904.Tter_2442	8.038e-44	164.0	COG0667@1|root,COG0667@2|Bacteria,2NP23@2323|unclassified Bacteria	2|Bacteria	C	Aldo/keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
DYD2_k127_5601697_3	1122611.KB903978_gene3337	3.147e-26	113.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4EITQ@85012|Streptosporangiales	201174|Actinobacteria	K	MraZ protein, putative antitoxin-like	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
DYD2_k127_5601697_0	1150864.MILUP08_45731	3.106e-50	187.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4D9I4@85008|Micromonosporales	201174|Actinobacteria	L	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
DYD2_k127_5601697_5	1122994.AUFR01000015_gene1824	1.787e-16	87.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4DPQ2@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
DYD2_k127_5601697_4	1205910.B005_3783	2.919e-17	89.0	2E49S@1|root,32Z5G@2|Bacteria,2IHN1@201174|Actinobacteria,4EJ6C@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
DYD2_k127_5601697_1	1415756.JQMY01000001_gene1898	2.768e-49	188.0	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria,2PCY9@252301|Oceanicola	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	MA20_16345	-	-	-	-	-	-	-	-	-	-	-	ECH_1
DYD2_k127_5601697_2	1274.HX89_06230	6.505e-32	131.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,1ZVU5@145357|Dermacoccaceae	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
DYD2_k127_5609746_6	309801.trd_1386	3.828e-45	173.0	2DPD0@1|root,331J4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5609746_7	28444.JODQ01000004_gene6220	9.141e-23	113.0	COG5276@1|root,COG5276@2|Bacteria,2IDWW@201174|Actinobacteria,4EH21@85012|Streptosporangiales	2|Bacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_5609746_0	479434.Sthe_2199	7.922e-245	777.0	COG2409@1|root,COG2409@2|Bacteria,2G6XZ@200795|Chloroflexi,27XX9@189775|Thermomicrobia	200795|Chloroflexi	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
DYD2_k127_5609746_3	987059.RBXJA2T_04813	4.72e-80	275.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1KJNR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
DYD2_k127_5609746_1	1123072.AUDH01000006_gene3332	3.328e-154	502.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2JPE6@204441|Rhodospirillales	204441|Rhodospirillales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
DYD2_k127_5609746_5	1120948.KB903217_gene1650	1.983e-51	188.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4DY8H@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
DYD2_k127_5609746_2	469383.Cwoe_3130	4.737e-94	321.0	2912K@1|root,2ZNQ4@2|Bacteria,2IGRH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5609746_4	469383.Cwoe_3131	7.716e-67	231.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
DYD2_k127_5614937_0	391037.Sare_3007	3.489e-178	573.0	COG3408@1|root,COG3408@2|Bacteria,2H31J@201174|Actinobacteria	201174|Actinobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5621784_0	416348.Hlac_2646	7.075e-27	114.0	COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota,23UGI@183963|Halobacteria	183963|Halobacteria	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
DYD2_k127_5621784_2	875328.JDM601_3382	7.155e-19	90.0	COG2337@1|root,COG2337@2|Bacteria,2IMGQ@201174|Actinobacteria,23B5D@1762|Mycobacteriaceae	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
DYD2_k127_5621784_1	2074.JNYD01000008_gene1157	1.228e-20	103.0	COG2227@1|root,COG2227@2|Bacteria,2GMMX@201174|Actinobacteria,4DXPQ@85010|Pseudonocardiales	201174|Actinobacteria	H	PFAM Methyltransferase domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
DYD2_k127_5635844_0	1283299.AUKG01000002_gene5166	3.156e-34	144.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CRHY@84995|Rubrobacteria	84995|Rubrobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4
DYD2_k127_5635844_2	1298863.AUEP01000010_gene4406	9.297e-27	115.0	COG0642@1|root,COG2197@1|root,COG2197@2|Bacteria,COG2205@2|Bacteria,2IB5N@201174|Actinobacteria,4DTB4@85009|Propionibacteriales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DYD2_k127_5635844_1	298654.FraEuI1c_1984	2.173e-31	131.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4ESRQ@85013|Frankiales	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
DYD2_k127_5635844_3	1121468.AUBR01000011_gene2520	2.641e-07	62.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,42F9G@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
DYD2_k127_5676234_1	512565.AMIS_21790	2.866e-85	295.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4DBND@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DYD2_k127_5676234_0	392499.Swit_1745	3.905e-164	530.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales	204457|Sphingomonadales	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
DYD2_k127_568395_0	1123024.AUII01000021_gene69	4.199e-159	512.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
DYD2_k127_568395_3	448385.sce5829	1.35e-51	193.0	COG0500@1|root,COG2226@2|Bacteria,1R51W@1224|Proteobacteria,43AS2@68525|delta/epsilon subdivisions,2X666@28221|Deltaproteobacteria,2Z27D@29|Myxococcales	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DYD2_k127_568395_1	1179773.BN6_34870	8.014e-68	241.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4E0A8@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	ko:K18471	ko00640,map00640	-	R10718	RC00739	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
DYD2_k127_568395_2	1120936.KB907210_gene5889	2.535e-60	219.0	COG3340@1|root,COG3340@2|Bacteria,2GZK5@201174|Actinobacteria,4EH0V@85012|Streptosporangiales	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
DYD2_k127_568395_4	479433.Caci_8755	1.957e-34	145.0	COG0318@1|root,COG0318@2|Bacteria,2I91U@201174|Actinobacteria	201174|Actinobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
DYD2_k127_5691194_1	1121441.AUCX01000018_gene1481	3.988e-30	121.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria,2MCF7@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
DYD2_k127_5691194_0	1313172.YM304_15360	5.775e-85	289.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4CN0C@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GlcNAc-PI de-N-acetylase	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
DYD2_k127_5691194_3	1051646.VITU9109_01992	1.407e-22	104.0	COG1714@1|root,COG1714@2|Bacteria,1NPQA@1224|Proteobacteria,1TC4Q@1236|Gammaproteobacteria,1XZKZ@135623|Vibrionales	135623|Vibrionales	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
DYD2_k127_5691194_2	1273125.Rrhod_1068	1.487e-26	119.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4FU6G@85025|Nocardiaceae	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
DYD2_k127_5694319_2	935866.JAER01000037_gene582	4.971e-58	210.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4DNWF@85009|Propionibacteriales	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
DYD2_k127_5694319_3	1123258.AQXZ01000009_gene1473	5.894e-52	194.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4FWYC@85025|Nocardiaceae	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
DYD2_k127_5694319_4	574087.Acear_0089	3.615e-35	143.0	COG1825@1|root,COG1825@2|Bacteria,1VA38@1239|Firmicutes,24N24@186801|Clostridia,3WBPT@53433|Halanaerobiales	186801|Clostridia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
DYD2_k127_5694319_1	525909.Afer_1597	3.045e-114	378.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4CMVQ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
DYD2_k127_5694319_0	469371.Tbis_3155	2.288e-130	430.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4DZZ7@85010|Pseudonocardiales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
DYD2_k127_5694319_5	58123.JOFJ01000029_gene1110	3.926e-13	77.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_8
DYD2_k127_5694915_2	465515.Mlut_19040	1.26e-14	79.0	COG3860@1|root,COG3860@2|Bacteria,2HTN1@201174|Actinobacteria,1WBVK@1268|Micrococcaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087
DYD2_k127_5694915_1	479434.Sthe_2903	4.772e-78	273.0	COG2025@1|root,COG2025@2|Bacteria,2G6PP@200795|Chloroflexi,27XU4@189775|Thermomicrobia	189775|Thermomicrobia	C	Electron transfer flavoprotein	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
DYD2_k127_5694915_0	1313172.YM304_09910	6.961e-83	282.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4CMXI@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
DYD2_k127_5694915_3	266117.Rxyl_1184	2.707e-10	67.0	COG3871@1|root,COG3871@2|Bacteria,2I2TZ@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
DYD2_k127_5695841_0	1116232.AHBF01000099_gene7260	1.121e-114	389.0	28IUR@1|root,2Z8TE@2|Bacteria,2I9P5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5701639_6	1123023.JIAI01000002_gene5480	4.652e-20	96.0	COG1481@1|root,COG1481@2|Bacteria,2GJZU@201174|Actinobacteria,4E12N@85010|Pseudonocardiales	201174|Actinobacteria	K	May be required for sporulation	whiA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
DYD2_k127_5701639_4	1123258.AQXZ01000018_gene1233	4.187e-52	198.0	COG0391@1|root,COG0391@2|Bacteria,2GJBW@201174|Actinobacteria,4FUHS@85025|Nocardiaceae	201174|Actinobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
DYD2_k127_5701639_3	1120936.KB907219_gene3093	1.756e-77	270.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4EGVC@85012|Streptosporangiales	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
DYD2_k127_5701639_2	469371.Tbis_1997	4.677e-202	646.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4DZ3F@85010|Pseudonocardiales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
DYD2_k127_5701639_0	469383.Cwoe_2882	0.0	1200.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4CPHN@84995|Rubrobacteria	84995|Rubrobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
DYD2_k127_5701639_7	1522072.IL54_2251	9.523e-18	91.0	COG2146@1|root,COG2146@2|Bacteria,1PEZF@1224|Proteobacteria,2U24J@28211|Alphaproteobacteria,2K8AI@204457|Sphingomonadales	204457|Sphingomonadales	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU,Rieske
DYD2_k127_5701639_5	1151118.KB895791_gene1917	1.078e-35	141.0	COG0644@1|root,COG1853@1|root,COG0644@2|Bacteria,COG1853@2|Bacteria,2GN9I@201174|Actinobacteria	201174|Actinobacteria	C	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DYD2_k127_5701639_1	448385.sce8137	4.519e-314	985.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42M33@68525|delta/epsilon subdivisions,2WJGS@28221|Deltaproteobacteria,2YU96@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
DYD2_k127_570886_2	350054.Mflv_3575	2.066e-19	94.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,235QN@1762|Mycobacteriaceae	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
DYD2_k127_570886_1	1869.MB27_39760	6.027e-45	174.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria,4D9YH@85008|Micromonosporales	201174|Actinobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
DYD2_k127_570886_3	351607.Acel_1209	3.628e-14	81.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
DYD2_k127_570886_0	1157490.EL26_00540	2.536e-129	432.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli,278ZE@186823|Alicyclobacillaceae	91061|Bacilli	IQ	PFAM AMP-dependent synthetase and ligase	lcfB_2	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DYD2_k127_5711506_7	1150599.MPHLEI_00592	4.247e-28	126.0	COG3631@1|root,COG3631@2|Bacteria,2IHRM@201174|Actinobacteria,2397K@1762|Mycobacteriaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
DYD2_k127_5711506_5	649638.Trad_2776	1.491e-38	154.0	COG3346@1|root,COG3346@2|Bacteria	2|Bacteria	S	mitochondrial respiratory chain complex IV assembly	surf1	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
DYD2_k127_5711506_2	1121946.AUAX01000009_gene4293	1.33e-142	466.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4D8CZ@85008|Micromonosporales	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
DYD2_k127_5711506_1	235985.BBPN01000053_gene7861	4.214e-154	493.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,2NG3I@228398|Streptacidiphilus	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_5711506_4	500153.JOEK01000002_gene313	1.21e-54	203.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DYD2_k127_5711506_0	717605.Theco_3327	2.385e-187	611.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,4HDVV@91061|Bacilli,26TT1@186822|Paenibacillaceae	91061|Bacilli	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
DYD2_k127_5711506_3	42256.RradSPS_1600	2.681e-84	289.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	CP_0969	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
DYD2_k127_5711506_6	42256.RradSPS_1599	1.99e-33	143.0	COG2403@1|root,COG2403@2|Bacteria,2H3G5@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	-
DYD2_k127_5772317_0	2002.JOEQ01000026_gene364	3.802e-78	278.0	COG5276@1|root,COG5276@2|Bacteria,2IDWW@201174|Actinobacteria,4EH21@85012|Streptosporangiales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_5772317_1	479434.Sthe_3186	1.307e-08	66.0	2EMH0@1|root,33F5M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
DYD2_k127_5775796_7	351607.Acel_0538	1.02e-57	206.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4ES6T@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase sigma factor	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_5775796_15	570268.ANBB01000024_gene5517	4.365e-07	57.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4EKIJ@85012|Streptosporangiales	201174|Actinobacteria	K	Putative zinc-finger	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
DYD2_k127_5775796_8	1048339.KB913029_gene3284	1.667e-51	199.0	COG2206@1|root,COG2206@2|Bacteria,2GJB1@201174|Actinobacteria,4EUK3@85013|Frankiales	201174|Actinobacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
DYD2_k127_5775796_4	351607.Acel_0546	1.27e-67	251.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4ETB2@85013|Frankiales	201174|Actinobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
DYD2_k127_5775796_16	1172188.KB911821_gene1956	3.31e-06	54.0	COG2452@1|root,COG2452@2|Bacteria,2GQJ9@201174|Actinobacteria,4FI4Q@85021|Intrasporangiaceae	201174|Actinobacteria	L	Helix-turn-helix domain	bldC	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DYD2_k127_5775796_17	138119.DSY0509	3.952e-06	58.0	2DMAW@1|root,32EM1@2|Bacteria,1UPNC@1239|Firmicutes,25HJQ@186801|Clostridia,2627W@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5775796_6	246197.MXAN_2712	9.193e-63	224.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,42RTA@68525|delta/epsilon subdivisions,2WNCA@28221|Deltaproteobacteria,2YV29@29|Myxococcales	28221|Deltaproteobacteria	I	enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
DYD2_k127_5775796_0	1283299.AUKG01000001_gene2768	5.206e-203	647.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CS0R@84995|Rubrobacteria	84995|Rubrobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
DYD2_k127_5775796_9	1229780.BN381_450060	7.235e-34	134.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,3UWVF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ATP-dependent Clp protease adaptor protein ClpS	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
DYD2_k127_5775796_13	1123320.KB889677_gene2771	9.799e-16	86.0	2E4AX@1|root,32Z6K@2|Bacteria,2GW4T@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
DYD2_k127_5775796_2	469383.Cwoe_1594	2.298e-108	357.0	COG3246@1|root,COG3246@2|Bacteria,2I9EQ@201174|Actinobacteria,4CT4T@84995|Rubrobacteria	84995|Rubrobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
DYD2_k127_5775796_12	1869.MB27_13065	1.246e-23	101.0	COG4770@1|root,COG4770@2|Bacteria,2I2DF@201174|Actinobacteria,4DFRH@85008|Micromonosporales	201174|Actinobacteria	I	Biotin lipoyl attachment domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
DYD2_k127_5775796_1	2002.JOEQ01000048_gene7423	9.902e-132	437.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4EG9F@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
DYD2_k127_5775796_10	351607.Acel_0560	2.942e-31	126.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,4ET35@85013|Frankiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
DYD2_k127_5775796_11	743718.Isova_0358	1.427e-27	121.0	COG0584@1|root,COG0584@2|Bacteria,2GNM5@201174|Actinobacteria,4F46D@85017|Promicromonosporaceae	201174|Actinobacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
DYD2_k127_5775796_5	1123320.KB889737_gene5367	3.645e-63	228.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
DYD2_k127_5775796_3	1313172.YM304_30860	5.927e-94	333.0	COG2936@1|root,COG2936@2|Bacteria,2IAA6@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_5818248_3	103690.17134151	6.988e-23	100.0	28PWG@1|root,2ZCGU@2|Bacteria,1G5G3@1117|Cyanobacteria,1HN4X@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3598
DYD2_k127_5818248_4	63737.Npun_R5421	2.82e-22	98.0	28PWG@1|root,2ZCGU@2|Bacteria,1G5G3@1117|Cyanobacteria,1HN4X@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3598
DYD2_k127_5818248_1	485913.Krac_2686	1.103e-71	258.0	KOG1110@1|root,2Z8YY@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1838)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1838
DYD2_k127_5818248_2	1265310.CCBD010000045_gene839	1.075e-40	164.0	COG2114@1|root,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria,234SY@1762|Mycobacteriaceae	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
DYD2_k127_5818248_0	710686.Mycsm_01630	7.978e-86	298.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,235VP@1762|Mycobacteriaceae	201174|Actinobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
DYD2_k127_5818248_5	646529.Desaci_1714	1.123e-08	67.0	COG0791@1|root,COG3583@1|root,COG0791@2|Bacteria,COG3583@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,25ZYR@186807|Peptococcaceae	186801|Clostridia	M	Cell wall-associated hydrolase, invasion-associated protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	G5,LysM,NLPC_P60
DYD2_k127_5818248_6	1297617.JPJD01000074_gene1632	3.332e-07	62.0	COG2340@1|root,COG5263@1|root,COG2340@2|Bacteria,COG5263@2|Bacteria	2|Bacteria	S	dextransucrase activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
DYD2_k127_5820504_1	1430440.MGMSRv2_2029	3.556e-35	139.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,2JPMK@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
DYD2_k127_5820504_0	1380347.JNII01000008_gene4351	7.211e-173	552.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4ERGV@85013|Frankiales	201174|Actinobacteria	E	PFAM Glutamine synthetase, catalytic	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DYD2_k127_5827084_3	58123.JOFJ01000006_gene137	5.373e-188	595.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4EGY4@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DYD2_k127_5827084_7	28042.GU90_18485	3.821e-80	280.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4DZ4G@85010|Pseudonocardiales	201174|Actinobacteria	M	UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
DYD2_k127_5827084_17	1188256.BASI01000001_gene276	1.06e-09	62.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,2UFJJ@28211|Alphaproteobacteria,3FEA3@34008|Rhodovulum	28211|Alphaproteobacteria	U	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
DYD2_k127_5827084_9	1123320.KB889571_gene5468	3.963e-61	220.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
DYD2_k127_5827084_14	525909.Afer_1800	4.727e-21	94.0	COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4CNBJ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
DYD2_k127_5827084_13	1068978.AMETH_0578	3.048e-22	104.0	COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4E2Q8@85010|Pseudonocardiales	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
DYD2_k127_5827084_10	1313172.YM304_10630	3.168e-41	160.0	COG0712@1|root,COG0712@2|Bacteria,2HGFG@201174|Actinobacteria,4CND3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
DYD2_k127_5827084_2	298654.FraEuI1c_0938	1.85e-213	674.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4ERF0@85013|Frankiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
DYD2_k127_5827084_8	471857.Svir_29560	1.212e-74	260.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4DXM0@85010|Pseudonocardiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
DYD2_k127_5827084_1	1048339.KB913029_gene3398	6.162e-218	685.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4ES4I@85013|Frankiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
DYD2_k127_5827084_15	1408254.T458_05750	3.634e-14	82.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,4HKHS@91061|Bacilli,26Y3T@186822|Paenibacillaceae	91061|Bacilli	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
DYD2_k127_5827084_4	1120950.KB892745_gene2885	1.135e-136	450.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4DND6@85009|Propionibacteriales	201174|Actinobacteria	M	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
DYD2_k127_5827084_16	768704.Desmer_3023	2.599e-11	75.0	COG1266@1|root,COG1266@2|Bacteria,1V4WD@1239|Firmicutes,24P4C@186801|Clostridia,261SJ@186807|Peptococcaceae	186801|Clostridia	S	PFAM CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DYD2_k127_5827084_11	1463903.JOIZ01000003_gene1743	9.457e-39	152.0	COG3255@1|root,COG3255@2|Bacteria	2|Bacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
DYD2_k127_5827084_12	2045.KR76_07585	4.93e-38	153.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4DNGF@85009|Propionibacteriales	201174|Actinobacteria	S	NADPH-dependent F420 reductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
DYD2_k127_5827084_6	926566.Terro_4363	1.975e-96	332.0	COG0258@1|root,COG0258@2|Bacteria,3Y2FG@57723|Acidobacteria,2JME1@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
DYD2_k127_5827084_5	1205910.B005_3230	3.291e-104	347.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4EHVD@85012|Streptosporangiales	201174|Actinobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
DYD2_k127_5827084_0	33876.JNXY01000008_gene8462	3.765e-240	765.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4DC8C@85008|Micromonosporales	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	icmA	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
DYD2_k127_5827084_18	644282.Deba_2770	2.482e-08	62.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42PPG@68525|delta/epsilon subdivisions,2WJGF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
DYD2_k127_5841131_2	1128421.JAGA01000003_gene2765	2.625e-18	94.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_5841131_0	1158318.ATXC01000001_gene1139	2.181e-110	374.0	COG1186@1|root,COG1186@2|Bacteria,2G3P3@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
DYD2_k127_5841131_1	264732.Moth_0236	4.601e-75	264.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
DYD2_k127_5847395_1	1122182.KB903834_gene5995	2.332e-120	392.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4DAXK@85008|Micromonosporales	201174|Actinobacteria	EK	Cystathionine beta-synthase	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
DYD2_k127_5847395_0	2074.JNYD01000005_gene3298	1.056e-158	514.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4DX61@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Cys Met metabolism	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
DYD2_k127_5847395_2	1313172.YM304_23520	5.878e-108	359.0	COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,4CMU1@84992|Acidimicrobiia	84992|Acidimicrobiia	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
DYD2_k127_590303_2	1121272.KB903251_gene859	6.585e-96	338.0	COG2304@1|root,COG4257@1|root,COG2304@2|Bacteria,COG4257@2|Bacteria,2IDJM@201174|Actinobacteria,4DEGK@85008|Micromonosporales	201174|Actinobacteria	V	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HYR,VWA
DYD2_k127_590303_0	1385520.N802_13870	2.232e-147	481.0	COG0151@1|root,COG0151@2|Bacteria,2I62N@201174|Actinobacteria,4FE38@85021|Intrasporangiaceae	201174|Actinobacteria	F	Belongs to the GarS family	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_590303_3	306281.AJLK01000207_gene5884	1.344e-26	120.0	COG4447@1|root,COG4447@2|Bacteria,1G13Q@1117|Cyanobacteria,1JJR7@1189|Stigonemataceae	1117|Cyanobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
DYD2_k127_590303_1	379066.GAU_0382	2.441e-145	492.0	COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
DYD2_k127_590303_4	931627.MycrhDRAFT_2269	1.096e-18	92.0	COG3915@1|root,COG3915@2|Bacteria,2H48S@201174|Actinobacteria,23DG6@1762|Mycobacteriaceae	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
DYD2_k127_5922619_2	351016.RAZWK3B_14034	1.344e-24	111.0	COG3647@1|root,COG3647@2|Bacteria,1RGJN@1224|Proteobacteria,2U80P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5922619_0	469383.Cwoe_2869	1.513e-62	232.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,2GNP7@201174|Actinobacteria,4CSP9@84995|Rubrobacteria	84995|Rubrobacteria	I	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit	-	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
DYD2_k127_5922619_1	1116232.AHBF01000018_gene3751	1.138e-59	208.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria	201174|Actinobacteria	I	Methylmalonyl-CoA mutase	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
DYD2_k127_5925223_1	1121920.AUAU01000011_gene197	3.324e-62	225.0	COG1372@1|root,COG1573@1|root,COG1372@2|Bacteria,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria	57723|Acidobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DYD2_k127_5925223_4	479435.Kfla_6039	3.966e-31	128.0	COG0454@1|root,COG0802@1|root,COG0456@2|Bacteria,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4DPK9@85009|Propionibacteriales	201174|Actinobacteria	K	Threonylcarbamoyl adenosine biosynthesis protein TsaE	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
DYD2_k127_5925223_6	1123288.SOV_1c03410	7.083e-17	90.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4H47Z@909932|Negativicutes	909932|Negativicutes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
DYD2_k127_5925223_3	1313172.YM304_08950	5.384e-32	138.0	COG0454@1|root,COG0456@2|Bacteria,2HGCA@201174|Actinobacteria,4CNAC@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DYD2_k127_5925223_0	1121428.DESHY_160202___1	3.568e-103	345.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,260QV@186807|Peptococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
DYD2_k127_5925223_5	1192034.CAP_8672	3.484e-20	95.0	COG2905@1|root,COG3202@1|root,COG2905@2|Bacteria,COG3202@2|Bacteria,1RERN@1224|Proteobacteria	1224|Proteobacteria	T	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
DYD2_k127_5925223_2	561175.KB894099_gene5067	1.048e-37	144.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4EJRJ@85012|Streptosporangiales	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
DYD2_k127_5932426_2	35754.JNYJ01000024_gene9152	1.934e-149	488.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4D931@85008|Micromonosporales	201174|Actinobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
DYD2_k127_5932426_16	498761.HM1_1757	5.503e-30	124.0	COG1945@1|root,COG1945@2|Bacteria,1V3K6@1239|Firmicutes,24HBN@186801|Clostridia	186801|Clostridia	S	PFAM Pyruvoyl-dependent arginine decarboxylase	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
DYD2_k127_5932426_15	309801.trd_0217	1.694e-30	126.0	COG1586@1|root,COG1586@2|Bacteria,2GA45@200795|Chloroflexi,27Z61@189775|Thermomicrobia	189775|Thermomicrobia	F	S-adenosylmethionine decarboxylase	-	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
DYD2_k127_5932426_7	570967.JMLV01000010_gene1152	2.607e-70	249.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,2TQZ3@28211|Alphaproteobacteria,2JRG9@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
DYD2_k127_5932426_9	458233.MCCL_1664	4.292e-50	188.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,4HA7S@91061|Bacilli,4GZKW@90964|Staphylococcaceae	91061|Bacilli	E	Arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DYD2_k127_5932426_11	1122603.ATVI01000006_gene119	1.654e-37	165.0	COG2373@1|root,COG4409@1|root,COG4625@1|root,COG2373@2|Bacteria,COG4409@2|Bacteria,COG4625@2|Bacteria,1PHJD@1224|Proteobacteria,1T8MC@1236|Gammaproteobacteria,1XAXM@135614|Xanthomonadales	135614|Xanthomonadales	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5932426_5	234267.Acid_4124	8.795e-82	310.0	COG1470@1|root,COG2931@1|root,COG1470@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,CarboxypepD_reg,DUF11,DUF5122,Kelch_1,NPCBM_assoc,VCBS
DYD2_k127_5932426_10	1003195.SCAT_3420	2.659e-46	177.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_5932426_21	1150864.MILUP08_46472	1.285e-08	66.0	COG3170@1|root,COG3170@2|Bacteria,2GJWK@201174|Actinobacteria,4DC1I@85008|Micromonosporales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5932426_20	1211815.CBYP010000015_gene2782	8.546e-09	65.0	2FG3N@1|root,34806@2|Bacteria,2I9A7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
DYD2_k127_5932426_12	40571.JOEA01000023_gene7265	1.079e-34	144.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DXNB@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
DYD2_k127_5932426_4	222534.KB893705_gene5865	3.619e-82	288.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4ERZF@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
DYD2_k127_5932426_0	1463864.JOGO01000007_gene613	4.349e-244	767.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria	201174|Actinobacteria	O	AAA ATPase forming ring-shaped complexes	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
DYD2_k127_5932426_1	298654.FraEuI1c_3753	1.093e-177	571.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4ERN8@85013|Frankiales	201174|Actinobacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
DYD2_k127_5932426_8	1150864.MILUP08_43052	7.778e-66	230.0	COG0406@1|root,COG0406@2|Bacteria,2IAPP@201174|Actinobacteria,4DDEI@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
DYD2_k127_5932426_19	711393.AYRX01000024_gene1495	1.998e-09	61.0	2E9C2@1|root,333JS@2|Bacteria,2IQ5V@201174|Actinobacteria	201174|Actinobacteria	S	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
DYD2_k127_5932426_14	1146883.BLASA_2675	7.71e-31	126.0	2EFG7@1|root,3398W@2|Bacteria,2ID0P@201174|Actinobacteria	201174|Actinobacteria	L	Recombination endonuclease VII	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_7
DYD2_k127_5932426_17	219305.MCAG_05502	2.566e-24	107.0	2EFG7@1|root,3398W@2|Bacteria,2ID0P@201174|Actinobacteria,4DGI7@85008|Micromonosporales	201174|Actinobacteria	L	Recombination endonuclease VII	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_7
DYD2_k127_5932426_3	525909.Afer_0910	2.932e-88	299.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4CMX8@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DYD2_k127_5932426_6	1385521.N803_08115	2.067e-76	263.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4FFJS@85021|Intrasporangiaceae	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DYD2_k127_5932426_13	29495.EA26_03490	1.812e-33	143.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1XSP4@135623|Vibrionales	135623|Vibrionales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
DYD2_k127_5932426_18	110319.CF8_1483	7.303e-24	105.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4DPUK@85009|Propionibacteriales	201174|Actinobacteria	Q	Multicopper oxidase	cotA	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
DYD2_k127_5949768_6	1122611.KB903996_gene7518	8.648e-18	84.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,4EJXS@85012|Streptosporangiales	201174|Actinobacteria	H	ThiS family	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DYD2_k127_5949768_0	1123023.JIAI01000003_gene2679	1.755e-128	418.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4DX6P@85010|Pseudonocardiales	201174|Actinobacteria	E	Cysteine synthase	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113	ko:K21148	ko04122,map04122	-	R10610	RC03225	ko00000,ko00001,ko01000	-	-	-	PALP
DYD2_k127_5949768_2	397278.JOJN01000007_gene3121	2.574e-77	268.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4DP8J@85009|Propionibacteriales	201174|Actinobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
DYD2_k127_5949768_5	1944.JOAZ01000015_gene4539	1.002e-40	167.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,41C75@629295|Streptomyces griseus group	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DYD2_k127_5949768_1	1120999.JONM01000006_gene2461	1.699e-79	274.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,2KPPZ@206351|Neisseriales	206351|Neisseriales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
DYD2_k127_5949768_4	309801.trd_0741	1.655e-44	169.0	COG0127@1|root,COG0127@2|Bacteria,2G6GK@200795|Chloroflexi,27YEQ@189775|Thermomicrobia	189775|Thermomicrobia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
DYD2_k127_5949768_3	1128421.JAGA01000003_gene2765	1.12e-67	249.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_5961807_0	1121422.AUMW01000020_gene1732	4.024e-143	464.0	COG1960@1|root,COG1960@2|Bacteria,1UYXJ@1239|Firmicutes,25BWS@186801|Clostridia,264HJ@186807|Peptococcaceae	186801|Clostridia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_5961807_1	1297742.A176_04464	5.46e-110	366.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42Q1R@68525|delta/epsilon subdivisions,2WM4U@28221|Deltaproteobacteria,2YWW8@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249,ko:K11731	ko00071,ko00280,ko00281,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00281,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R08089	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC01893	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_5968145_1	43759.JNWK01000011_gene6265	1.941e-63	225.0	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria	201174|Actinobacteria	I	Pfam SNARE associated Golgi protein	yqjA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
DYD2_k127_5968145_3	43989.cce_2860	7.952e-22	100.0	COG2337@1|root,COG2337@2|Bacteria,1GKIE@1117|Cyanobacteria,3KK5N@43988|Cyanothece	1117|Cyanobacteria	L	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
DYD2_k127_5968145_2	561175.KB894093_gene3554	2.968e-59	222.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria,4EG3M@85012|Streptosporangiales	201174|Actinobacteria	L	DNA polymerase III, delta subunit	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
DYD2_k127_5968145_0	1048339.KB913029_gene1193	9.493e-126	432.0	COG0125@1|root,COG0477@1|root,COG0125@2|Bacteria,COG0477@2|Bacteria,2GNTI@201174|Actinobacteria,4ES48@85013|Frankiales	201174|Actinobacteria	EFGP	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
DYD2_k127_5968145_4	1120950.KB892773_gene1083	2.615e-08	65.0	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4DT8Y@85009|Propionibacteriales	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5971052_0	234267.Acid_5391	1.206e-144	470.0	COG2609@1|root,COG2609@2|Bacteria,3Y2M3@57723|Acidobacteria	57723|Acidobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
DYD2_k127_5971052_4	1068978.AMETH_5925	1.315e-07	64.0	2E9GJ@1|root,333PP@2|Bacteria,2HC60@201174|Actinobacteria	201174|Actinobacteria	S	Lysyl oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Lysyl_oxidase
DYD2_k127_5971052_2	469383.Cwoe_1595	9.407e-114	378.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4CU2K@84995|Rubrobacteria	84995|Rubrobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
DYD2_k127_5971052_3	1348663.KCH_22140	4.951e-20	91.0	2ES7R@1|root,33JSG@2|Bacteria,2IQ6C@201174|Actinobacteria,2M3MC@2063|Kitasatospora	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5971052_1	749927.AMED_2206	1.934e-115	393.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,4E0J9@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
DYD2_k127_5972516_0	525264.HMPREF0305_10326	8.492e-122	398.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,22JJZ@1653|Corynebacteriaceae	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
DYD2_k127_5972516_3	316274.Haur_2516	1.787e-32	134.0	COG0632@1|root,COG0632@2|Bacteria,2G6V7@200795|Chloroflexi,3774D@32061|Chloroflexia	32061|Chloroflexia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
DYD2_k127_5972516_2	326427.Cagg_2595	3.387e-40	156.0	COG0817@1|root,COG0817@2|Bacteria,2G6MA@200795|Chloroflexi,375KP@32061|Chloroflexia	32061|Chloroflexia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
DYD2_k127_5972516_1	356851.JOAN01000028_gene548	5.947e-53	197.0	COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4D90V@85008|Micromonosporales	201174|Actinobacteria	DT	Serine threonine protein kinase involved in cell cycle control	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
DYD2_k127_5972516_4	234267.Acid_3360	5.521e-06	58.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Flg_new,Laminin_G_3,PSII_BNR,SLH,Sortilin-Vps10,fn3
DYD2_k127_5981935_0	1380390.JIAT01000010_gene3955	3.375e-58	222.0	COG0681@1|root,COG0681@2|Bacteria,2IDET@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF5305,Peptidase_S24
DYD2_k127_5981935_1	926569.ANT_02840	3.199e-15	82.0	COG2931@1|root,COG2931@2|Bacteria,2G9JH@200795|Chloroflexi	200795|Chloroflexi	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
DYD2_k127_6003308_3	479434.Sthe_2158	6.748e-82	282.0	COG1233@1|root,COG1233@2|Bacteria,2G5SE@200795|Chloroflexi,27Y46@189775|Thermomicrobia	189775|Thermomicrobia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
DYD2_k127_6003308_5	1283299.AUKG01000002_gene4021	4.789e-61	231.0	COG1024@1|root,COG1024@2|Bacteria,2GJ63@201174|Actinobacteria,4CS7T@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
DYD2_k127_6003308_7	1382356.JQMP01000001_gene1284	2.375e-20	99.0	COG5349@1|root,COG5349@2|Bacteria,2G7FQ@200795|Chloroflexi,27ZAC@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
DYD2_k127_6003308_4	1415166.NONO_c51110	8.621e-78	277.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4FTWX@85025|Nocardiaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	acoD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
DYD2_k127_6003308_1	330214.NIDE2204	2.513e-102	344.0	COG1023@1|root,COG1023@2|Bacteria	2|Bacteria	G	D-gluconate metabolic process	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
DYD2_k127_6003308_0	326427.Cagg_3190	5.258e-138	458.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
DYD2_k127_6003308_6	706587.Desti_2107	7.774e-50	198.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,42SY1@68525|delta/epsilon subdivisions,2WPQ7@28221|Deltaproteobacteria,2MSBX@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
DYD2_k127_6003308_2	1463825.JNXC01000008_gene1277	1.298e-93	311.0	COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DZEF@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DYD2_k127_6011225_0	1128421.JAGA01000003_gene3714	3.341e-78	269.0	COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria	2|Bacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
DYD2_k127_6011225_3	1489678.RDMS_00100	8.267e-26	111.0	COG0789@1|root,COG0789@2|Bacteria,1WJ4G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM MerR family regulatory protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
DYD2_k127_6011225_1	1385519.N801_06055	1.29e-66	238.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4FECM@85021|Intrasporangiaceae	201174|Actinobacteria	O	molecular chaperone	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DYD2_k127_6011225_2	986075.CathTA2_2226	4.455e-29	123.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
DYD2_k127_6023858_2	2045.KR76_15715	9.256e-05	55.0	COG1277@1|root,COG1277@2|Bacteria,2GVAC@201174|Actinobacteria,4DSDI@85009|Propionibacteriales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
DYD2_k127_6023858_0	1121272.KB903272_gene166	3.98e-82	284.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4DAX5@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_6023858_1	1306406.ASHX01000002_gene4811	3.988e-54	201.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
DYD2_k127_6051967_6	1404245.CGLY_08935	1.077e-38	155.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,22JTV@1653|Corynebacteriaceae	201174|Actinobacteria	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
DYD2_k127_6051967_3	1168059.KB899087_gene954	9.457e-90	306.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,3EYYC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
DYD2_k127_6051967_4	65497.JODV01000008_gene246	8.842e-89	303.0	COG1801@1|root,COG1801@2|Bacteria,2HNT3@201174|Actinobacteria,4E0DV@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
DYD2_k127_6051967_2	561175.KB894094_gene1484	6.611e-105	361.0	COG2303@1|root,COG2303@2|Bacteria,2IDQ8@201174|Actinobacteria	201174|Actinobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
DYD2_k127_6051967_8	1184609.KILIM_052_00250	1.134e-09	65.0	COG0784@1|root,COG0784@2|Bacteria,2II71@201174|Actinobacteria,4F6ZE@85018|Dermatophilaceae	201174|Actinobacteria	T	cheY-homologous receiver domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_6051967_5	264201.pc0796	9.066e-55	205.0	COG0580@1|root,COG0580@2|Bacteria,2JGJ6@204428|Chlamydiae	204428|Chlamydiae	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	-	-	-	-	-	-	-	-	-	MIP
DYD2_k127_6051967_7	717231.Flexsi_1638	1.711e-38	148.0	COG3152@1|root,COG3152@2|Bacteria,2GGNJ@200930|Deferribacteres	200930|Deferribacteres	S	Protein of unknown function (DUF805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF805
DYD2_k127_6051967_1	1120950.KB892779_gene945	5.93e-152	487.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4DQ3H@85009|Propionibacteriales	201174|Actinobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
DYD2_k127_6051967_0	1449353.JQMQ01000005_gene3463	1.734e-227	715.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,2NEUH@228398|Streptacidiphilus	201174|Actinobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
DYD2_k127_6063595_2	566461.SSFG_04341	4.415e-49	182.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
DYD2_k127_6063595_0	65497.JODV01000006_gene847	2.461e-311	974.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4DX6M@85010|Pseudonocardiales	201174|Actinobacteria	H	Elongator protein 3, MiaB family, Radical SAM	fbiC	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
DYD2_k127_6063595_4	570268.ANBB01000033_gene2204	7.081e-07	63.0	COG1196@1|root,COG1196@2|Bacteria,2IHES@201174|Actinobacteria,4EIK4@85012|Streptosporangiales	201174|Actinobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6063595_3	1074488.AGBX01000007_gene2040	5.269e-32	126.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4FCXW@85020|Dermabacteraceae	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
DYD2_k127_6063595_1	1463895.JODA01000022_gene7749	2.222e-68	258.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
DYD2_k127_6079628_0	1313421.JHBV01000021_gene4856	5.707e-49	179.0	COG3631@1|root,COG3631@2|Bacteria,4NQGX@976|Bacteroidetes,1IYJ8@117747|Sphingobacteriia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
DYD2_k127_6079628_1	43354.JOIJ01000010_gene2463	1.063e-47	173.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4E0GA@85010|Pseudonocardiales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
DYD2_k127_6082453_2	1177181.T9A_02749	1.174e-38	156.0	COG2813@1|root,COG2813@2|Bacteria,1MXE9@1224|Proteobacteria,1RQCH@1236|Gammaproteobacteria,1XK72@135619|Oceanospirillales	135619|Oceanospirillales	J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle	rsmC	-	2.1.1.172	ko:K00564	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS,MTS_N
DYD2_k127_6082453_3	1463820.JOGW01000002_gene6471	1.059e-15	79.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
DYD2_k127_6082453_1	926550.CLDAP_37690	1.658e-45	171.0	COG1898@1|root,COG1898@2|Bacteria,2G7AS@200795|Chloroflexi	200795|Chloroflexi	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
DYD2_k127_6082453_0	644283.Micau_2921	0.0	1070.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DB0D@85008|Micromonosporales	201174|Actinobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
DYD2_k127_6083442_8	68260.JOAY01000056_gene5436	6.001e-14	82.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
DYD2_k127_6083442_3	929712.KI912613_gene3469	2.104e-50	189.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4CQ7R@84995|Rubrobacteria	84995|Rubrobacteria	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
DYD2_k127_6083442_5	1120936.KB907219_gene3070	7.061e-45	176.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4EH46@85012|Streptosporangiales	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
DYD2_k127_6083442_2	58123.JOFJ01000006_gene95	2.838e-127	421.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4EHB1@85012|Streptosporangiales	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
DYD2_k127_6083442_7	479431.Namu_4070	5.177e-22	108.0	2D1T0@1|root,32TBA@2|Bacteria,2I8E5@201174|Actinobacteria,4ET7I@85013|Frankiales	201174|Actinobacteria	S	Copper transport outer membrane protein, MctB	mctB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796	-	-	-	-	-	-	-	-	-	-	MctB
DYD2_k127_6083442_4	1121428.DESHY_60112___1	6.246e-45	176.0	COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,25E7R@186801|Clostridia,266RZ@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_6083442_6	446468.Ndas_3022	2.413e-26	121.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria,4EG6C@85012|Streptosporangiales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6083442_0	1313172.YM304_24900	2.214e-226	713.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4CMQD@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
DYD2_k127_6083442_1	469371.Tbis_0822	8.083e-134	436.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4DYAJ@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the AlaDH PNT family	ald	GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
DYD2_k127_6095323_2	224324.aq_608	2.15e-15	79.0	COG0498@1|root,COG0498@2|Bacteria,2G4SE@200783|Aquificae	200783|Aquificae	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC_1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_6095323_1	1211815.CBYP010000028_gene1041	3.642e-52	195.0	COG0561@1|root,COG0561@2|Bacteria,2IRCG@201174|Actinobacteria,4EUX0@85013|Frankiales	201174|Actinobacteria	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
DYD2_k127_6095323_0	390989.JOEG01000009_gene957	8.616e-55	207.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4DB1E@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
DYD2_k127_6100781_1	1380390.JIAT01000013_gene145	8.641e-32	139.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
DYD2_k127_6100781_0	298655.KI912267_gene6642	1.681e-102	346.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4ERZM@85013|Frankiales	201174|Actinobacteria	S	Belongs to the CinA family	cinA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
DYD2_k127_6107549_1	266940.Krad_1890	6.88e-67	242.0	COG0815@1|root,COG0815@2|Bacteria,2GJ9F@201174|Actinobacteria	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	GO:0000030,GO:0003674,GO:0003824,GO:0004582,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0070085,GO:0071704,GO:0071944,GO:0075136,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	iNJ661.Rv2051c	CN_hydrolase
DYD2_k127_6107549_0	1121926.AXWO01000027_gene345	2.145e-71	255.0	COG1215@1|root,COG1215@2|Bacteria,2I2PK@201174|Actinobacteria,4EZ2N@85014|Glycomycetales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
DYD2_k127_6107549_2	1306990.BARG01000025_gene2905	8.793e-53	199.0	COG0665@1|root,COG0665@2|Bacteria,2I9WR@201174|Actinobacteria	201174|Actinobacteria	E	Sarcosine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
DYD2_k127_6107549_3	58123.JOFJ01000013_gene4926	2.294e-34	142.0	COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EHHD@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_6109202_5	1125863.JAFN01000001_gene1462	6.735e-67	232.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
DYD2_k127_6109202_6	660470.Theba_2354	1.851e-51	191.0	COG3437@1|root,COG5000@1|root,COG3437@2|Bacteria,COG5000@2|Bacteria,2GCQ2@200918|Thermotogae	200918|Thermotogae	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5,Response_reg
DYD2_k127_6109202_8	465541.ATCJ01000005_gene7136	1.574e-28	119.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DYD2_k127_6109202_7	1120934.KB894451_gene2938	1.355e-29	127.0	2DP8R@1|root,32UKH@2|Bacteria,2IFBP@201174|Actinobacteria,4E378@85010|Pseudonocardiales	201174|Actinobacteria	-	-	amfC	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6109202_3	1048834.TC41_0182	5.471e-120	403.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HEG0@91061|Bacilli,27ANS@186823|Alicyclobacillaceae	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DYD2_k127_6109202_4	1283299.AUKG01000004_gene1030	6.519e-104	360.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CPH0@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC transporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
DYD2_k127_6109202_0	1120950.KB892773_gene1095	1.959e-207	663.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DPXV@85009|Propionibacteriales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DYD2_k127_6109202_9	1313172.YM304_31920	3.518e-19	97.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
DYD2_k127_6109202_2	1144275.COCOR_04995	3.37e-123	416.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42Q1R@68525|delta/epsilon subdivisions,2WM4U@28221|Deltaproteobacteria,2YWW8@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249,ko:K11731	ko00071,ko00280,ko00281,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00281,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R08089	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC01893	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_6109202_1	1121422.AUMW01000020_gene1732	1.531e-141	462.0	COG1960@1|root,COG1960@2|Bacteria,1UYXJ@1239|Firmicutes,25BWS@186801|Clostridia,264HJ@186807|Peptococcaceae	186801|Clostridia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_6109202_10	1206741.BAFX01000084_gene6270	1.813e-09	70.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6115446_2	1123023.JIAI01000015_gene3199	2.629e-21	104.0	2DHRC@1|root,32U9K@2|Bacteria,2II2K@201174|Actinobacteria,4E4I1@85010|Pseudonocardiales	201174|Actinobacteria	S	Family of unknown function (DUF5319)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5319
DYD2_k127_6115446_1	2002.JOEQ01000005_gene3792	1.762e-76	273.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria	201174|Actinobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
DYD2_k127_6115446_0	1110697.NCAST_13_00330	2.036e-83	285.0	COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4FV5H@85025|Nocardiaceae	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006066,GO:0006629,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0030283,GO:0032502,GO:0033764,GO:0033993,GO:0042221,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044594,GO:0046983,GO:0048545,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:1901360,GO:1901615,GO:1902652	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_6135497_3	1123237.Salmuc_03544	2.684e-06	51.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
DYD2_k127_6135497_1	875328.JDM601_3382	4.098e-22	103.0	COG2337@1|root,COG2337@2|Bacteria,2IMGQ@201174|Actinobacteria,23B5D@1762|Mycobacteriaceae	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
DYD2_k127_6135497_2	266940.Krad_2256	1.279e-16	86.0	COG0454@1|root,COG0456@2|Bacteria,2H0M6@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_6135497_0	351607.Acel_2115	4.204e-270	844.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4ERTY@85013|Frankiales	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
DYD2_k127_6140890_3	1120950.KB892741_gene2674	7.415e-142	462.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4DPA7@85009|Propionibacteriales	201174|Actinobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
DYD2_k127_6140890_9	1380347.JNII01000005_gene3893	1.631e-51	200.0	COG1073@1|root,COG1073@2|Bacteria,2IBGB@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6140890_2	264732.Moth_2255	1.348e-175	565.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,42EXZ@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DYD2_k127_6140890_11	1035308.AQYY01000002_gene481	4.451e-24	119.0	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,24JSE@186801|Clostridia,2620V@186807|Peptococcaceae	186801|Clostridia	G	PFAM Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
DYD2_k127_6140890_7	1380390.JIAT01000010_gene4495	2.21e-57	205.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4CQ8R@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
DYD2_k127_6140890_0	469383.Cwoe_3550	1.403e-210	663.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4CPQW@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
DYD2_k127_6140890_8	469383.Cwoe_3551	8.189e-56	202.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,2GN0H@201174|Actinobacteria,4CQKX@84995|Rubrobacteria	84995|Rubrobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
DYD2_k127_6140890_10	58123.JOFJ01000012_gene5388	3.414e-41	163.0	2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
DYD2_k127_6140890_5	479432.Sros_8042	5.215e-128	418.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4EH4W@85012|Streptosporangiales	201174|Actinobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DYD2_k127_6140890_1	106370.Francci3_3628	9.883e-179	574.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4ERX1@85013|Frankiales	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DYD2_k127_6140890_6	1177594.MIC448_10006	2.613e-84	294.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4FKZX@85023|Microbacteriaceae	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	fahA	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
DYD2_k127_6140890_4	1120950.KB892741_gene2686	2.698e-129	431.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4DPQP@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
DYD2_k127_6141948_8	1134413.ANNK01000031_gene1421	6.855e-11	72.0	COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,1ZDI1@1386|Bacillus	91061|Bacilli	M	COG3103 SH3 domain protein	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1,SH3_3,SH3_4,SH3_8,SLH
DYD2_k127_6141948_0	880072.Desac_1040	2.147e-174	557.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DYD2_k127_6141948_2	1464048.JNZS01000002_gene370	9.137e-62	220.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4D9JD@85008|Micromonosporales	201174|Actinobacteria	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
DYD2_k127_6141948_9	47716.JOFH01000031_gene7313	1.08e-07	62.0	2DR5D@1|root,33A8R@2|Bacteria,2GP44@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2993)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2993
DYD2_k127_6141948_6	882086.SacxiDRAFT_1842	6.874e-15	83.0	COG2345@1|root,COG2345@2|Bacteria,2IAWJ@201174|Actinobacteria,4E5TR@85010|Pseudonocardiales	201174|Actinobacteria	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR
DYD2_k127_6141948_7	1380347.JNII01000010_gene2524	2.66e-11	69.0	2AN8T@1|root,31D6V@2|Bacteria,2IHRU@201174|Actinobacteria,4EXIX@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
DYD2_k127_6141948_5	1157640.AQWO01000002_gene4177	2.263e-16	87.0	COG0526@1|root,COG0526@2|Bacteria,2IKMI@201174|Actinobacteria	201174|Actinobacteria	CO	Thioredoxin	thiX	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
DYD2_k127_6141948_1	644282.Deba_3251	2.067e-111	374.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2WJE6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_6141948_4	1380356.JNIK01000016_gene3583	1.866e-32	138.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,4ESPK@85013|Frankiales	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
DYD2_k127_6141948_3	1117379.BABA_12101	4.48e-42	164.0	COG2267@1|root,COG2267@2|Bacteria,1UKWC@1239|Firmicutes,4ITKP@91061|Bacilli	91061|Bacilli	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
DYD2_k127_6259671_2	491916.RHECIAT_PC0000419	3.719e-13	74.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,4BBEP@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
DYD2_k127_6259671_3	1380390.JIAT01000009_gene400	3.312e-06	54.0	COG2227@1|root,COG2227@2|Bacteria,2GMMX@201174|Actinobacteria,4CP67@84995|Rubrobacteria	84995|Rubrobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
DYD2_k127_6259671_0	1089545.KB913037_gene2265	4.188e-149	486.0	COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria,4DZ44@85010|Pseudonocardiales	201174|Actinobacteria	Q	Retinal pigment epithelial membrane protein	-	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
DYD2_k127_6259671_1	1229780.BN381_290057	2.788e-88	298.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,3UXH6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_6260621_0	1121438.JNJA01000001_gene2112	1.127e-60	221.0	COG0279@1|root,COG2605@1|root,COG0279@2|Bacteria,COG2605@2|Bacteria,1QWU7@1224|Proteobacteria,42QI3@68525|delta/epsilon subdivisions,2X8DE@28221|Deltaproteobacteria,2MGSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,SIS_2
DYD2_k127_6260621_1	383372.Rcas_0448	5.639e-47	180.0	COG0241@1|root,COG0241@2|Bacteria,2G6V8@200795|Chloroflexi,375WG@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM histidinol-phosphate phosphatase family protein	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
DYD2_k127_6260621_2	237368.SCABRO_02713	2.485e-41	167.0	COG0279@1|root,COG0279@2|Bacteria,2IZ19@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoheptose isomerase	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
DYD2_k127_6260621_3	518766.Rmar_1140	3.25e-06	59.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_6270175_0	1445613.JALM01000005_gene1145	3.356e-164	527.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4DX5C@85010|Pseudonocardiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_6270175_1	1122611.KB903996_gene7555	2.965e-74	259.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria,4EP82@85012|Streptosporangiales	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DYD2_k127_6270175_2	471852.Tcur_3898	5.261e-17	92.0	2E3EP@1|root,32YDP@2|Bacteria,2GQST@201174|Actinobacteria,4EKFS@85012|Streptosporangiales	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6297913_1	1183438.GKIL_0112	2.061e-66	247.0	COG0475@1|root,COG0475@2|Bacteria,1G03Z@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM Sodium hydrogen exchanger family	kefB	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
DYD2_k127_6297913_2	29581.BW37_00671	5.643e-05	54.0	COG0745@1|root,COG0745@2|Bacteria,1MUNV@1224|Proteobacteria,2VPU3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
DYD2_k127_6297913_0	1173022.Cri9333_4608	3.806e-148	484.0	COG0004@1|root,COG0004@2|Bacteria,1G0S8@1117|Cyanobacteria,1H6WR@1150|Oscillatoriales	1117|Cyanobacteria	U	ammonium transporteR	amt1	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DYD2_k127_6304756_8	298655.KI912266_gene5070	3.624e-28	130.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
DYD2_k127_6304756_9	1122137.AQXF01000004_gene1838	1.129e-22	112.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
DYD2_k127_6304756_7	309799.DICTH_1305	2.436e-34	141.0	COG1544@1|root,COG1544@2|Bacteria	2|Bacteria	J	regulation of translation	raiA	-	-	ko:K03733,ko:K05808,ko:K05809	-	-	-	-	ko00000,ko03009,ko03036	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
DYD2_k127_6304756_4	298654.FraEuI1c_6044	1.161e-90	303.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4ERMX@85013|Frankiales	201174|Actinobacteria	K	Response regulator receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
DYD2_k127_6304756_6	1229780.BN381_100035	1.156e-36	152.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria,3UWQY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Helix-turn-helix diphteria tox regulatory element	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
DYD2_k127_6304756_2	1278073.MYSTI_00745	1.515e-102	343.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,42NKM@68525|delta/epsilon subdivisions,2WM4Z@28221|Deltaproteobacteria,2YZ1V@29|Myxococcales	28221|Deltaproteobacteria	P	Bacterial extracellular solute-binding protein	futA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
DYD2_k127_6304756_0	266117.Rxyl_1174	1.242e-138	463.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
DYD2_k127_6304756_3	479434.Sthe_3206	2.97e-91	314.0	COG3842@1|root,COG3842@2|Bacteria,2G5P8@200795|Chloroflexi,27Z2U@189775|Thermomicrobia	189775|Thermomicrobia	E	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
DYD2_k127_6304756_5	661478.OP10G_0909	5.164e-72	248.0	COG0020@1|root,COG0020@2|Bacteria	2|Bacteria	I	transferase activity, transferring alkyl or aryl (other than methyl) groups	uppS2	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
DYD2_k127_6304756_1	446466.Cfla_2325	1.298e-118	393.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4F0HT@85016|Cellulomonadaceae	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
DYD2_k127_6315076_0	1541065.JRFE01000022_gene3884	4.281e-63	234.0	COG0744@1|root,COG0744@2|Bacteria,1G1XF@1117|Cyanobacteria,3VIDV@52604|Pleurocapsales	1117|Cyanobacteria	M	PFAM Penicillin binding protein transpeptidase domain	mrcB	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
DYD2_k127_6315076_1	479431.Namu_1150	2.372e-32	144.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria	201174|Actinobacteria	J	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,GT87,Mannosyl_trans
DYD2_k127_6324081_6	1122130.AUHN01000008_gene1581	3.447e-15	76.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria	201174|Actinobacteria	NOU	Peptidase A24A, prepilin type IV	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
DYD2_k127_6324081_9	396595.TK90_0212	0.0002859	50.0	COG4966@1|root,COG4966@2|Bacteria,1NHI1@1224|Proteobacteria,1SH60@1236|Gammaproteobacteria,1X2H1@135613|Chromatiales	135613|Chromatiales	NU	Type IV Pilus-assembly protein W	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
DYD2_k127_6324081_8	717606.PaecuDRAFT_2136	3.729e-09	69.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
DYD2_k127_6324081_7	1121877.JQKF01000024_gene2394	1.591e-11	71.0	COG4969@1|root,COG4969@2|Bacteria,2I7DS@201174|Actinobacteria	201174|Actinobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
DYD2_k127_6324081_2	351607.Acel_1320	1.643e-123	415.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4ERP7@85013|Frankiales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	tapC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
DYD2_k127_6324081_1	351607.Acel_1321	5.965e-146	479.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria,4ES1W@85013|Frankiales	201174|Actinobacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
DYD2_k127_6324081_0	1304865.JAGF01000001_gene3210	1.796e-209	665.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
DYD2_k127_6324081_4	1313172.YM304_20320	3.463e-46	181.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4CN43@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
DYD2_k127_6324081_3	42256.RradSPS_1365	1.492e-56	213.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4CQ8A@84995|Rubrobacteria	84995|Rubrobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
DYD2_k127_6324081_5	1382304.JNIL01000001_gene947	7.24e-17	85.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,4HH04@91061|Bacilli,278JB@186823|Alicyclobacillaceae	91061|Bacilli	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
DYD2_k127_6355247_1	443218.AS9A_4283	3.898e-16	82.0	COG2050@1|root,COG2050@2|Bacteria,2GKY1@201174|Actinobacteria,238HG@1762|Mycobacteriaceae	201174|Actinobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_6355247_0	391625.PPSIR1_41739	6.307e-18	98.0	COG3356@1|root,COG3356@2|Bacteria,1Q66U@1224|Proteobacteria,4358C@68525|delta/epsilon subdivisions,2WZJF@28221|Deltaproteobacteria,2Z29I@29|Myxococcales	28221|Deltaproteobacteria	S	Neutral/alkaline non-lysosomal ceramidase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
DYD2_k127_63578_0	1463841.JOIR01000003_gene5709	2.15e-147	475.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
DYD2_k127_63578_3	292459.STH1225	4.713e-41	162.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia	186801|Clostridia	L	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
DYD2_k127_63578_2	443143.GM18_2574	1.799e-41	161.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,43TVQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
DYD2_k127_63578_4	1122939.ATUD01000019_gene1540	1.11e-27	118.0	COG1799@1|root,COG1799@2|Bacteria,2GNVH@201174|Actinobacteria,4CQ0C@84995|Rubrobacteria	84995|Rubrobacteria	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
DYD2_k127_63578_5	1121933.AUHH01000025_gene3099	1.088e-12	70.0	COG0762@1|root,COG0762@2|Bacteria,2GQI1@201174|Actinobacteria,4DSEJ@85009|Propionibacteriales	201174|Actinobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
DYD2_k127_63578_6	1304880.JAGB01000001_gene585	1.649e-07	59.0	COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia	186801|Clostridia	D	PFAM DivIVA family protein	divIVA	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
DYD2_k127_63578_1	1122217.KB899585_gene216	1.813e-52	194.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H2Z8@909932|Negativicutes	909932|Negativicutes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
DYD2_k127_6371806_1	1394178.AWOO02000020_gene7377	9.968e-80	277.0	COG0491@1|root,COG0491@2|Bacteria,2I9GW@201174|Actinobacteria,4EGY5@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DYD2_k127_6371806_3	1121946.AUAX01000019_gene7777	6.252e-26	117.0	COG3340@1|root,COG3340@2|Bacteria,2ISWE@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
DYD2_k127_6371806_4	365528.KB891223_gene1295	0.0007594	51.0	COG0457@1|root,COG0457@2|Bacteria,2GKX5@201174|Actinobacteria,4ESUY@85013|Frankiales	201174|Actinobacteria	S	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
DYD2_k127_6371806_2	1869.MB27_13970	3.372e-43	177.0	COG0642@1|root,COG2205@2|Bacteria,2I2UR@201174|Actinobacteria,4DH72@85008|Micromonosporales	201174|Actinobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DYD2_k127_6371806_0	1380354.JIAN01000009_gene3700	1.046e-113	377.0	COG1215@1|root,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
DYD2_k127_6379255_0	351607.Acel_0073	5.535e-73	254.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4EXEW@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_6379255_1	525904.Tter_0922	3.554e-38	154.0	COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria	2|Bacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
DYD2_k127_6379255_2	345341.KUTG_07675	4.822e-24	108.0	COG1670@1|root,COG1670@2|Bacteria,2HNQA@201174|Actinobacteria,4E74E@85010|Pseudonocardiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DYD2_k127_6379255_3	1157637.KB892101_gene2503	1.168e-19	98.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
DYD2_k127_6386673_0	253839.SSNG_01152	5.581e-24	109.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria	201174|Actinobacteria	M	Acetyltransferase (isoleucine patch	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
DYD2_k127_6386673_1	1392493.JIAB01000001_gene1722	2.824e-15	83.0	COG0110@1|root,COG0110@2|Bacteria,1VFFY@1239|Firmicutes	1239|Firmicutes	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
DYD2_k127_639198_2	1894.JOER01000017_gene4885	2.889e-24	116.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	1.1.3.9	ko:K04618	ko00052,map00052	-	R01098	RC00194	ko00000,ko00001,ko01000	-	-	-	DUF4082,RicinB_lectin_2
DYD2_k127_639198_3	269799.Gmet_2298	3.289e-21	105.0	COG1466@1|root,COG1466@2|Bacteria,1RHE9@1224|Proteobacteria,42SNR@68525|delta/epsilon subdivisions,2WP96@28221|Deltaproteobacteria,43TIV@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
DYD2_k127_639198_1	66429.JOFL01000001_gene4646	1.975e-26	125.0	COG3509@1|root,COG3509@2|Bacteria,2I4GT@201174|Actinobacteria	201174|Actinobacteria	Q	Ricin-type beta-trefoil	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_3,RicinB_lectin_2
DYD2_k127_639198_0	1463821.JOGR01000006_gene2592	9.734e-62	229.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4EY1T@85014|Glycomycetales	201174|Actinobacteria	S	Competence protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
DYD2_k127_639524_0	105425.BBPL01000100_gene1216	4.045e-165	537.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,2NFYU@228398|Streptacidiphilus	201174|Actinobacteria	D	Ftsk_gamma	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
DYD2_k127_639524_1	1095727.HMPREF1117_0342	6.541e-06	53.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4HI2E@91061|Bacilli	91061|Bacilli	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
DYD2_k127_6406860_4	1298863.AUEP01000010_gene4408	0.0001305	53.0	2EB70@1|root,3357M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6406860_0	1128421.JAGA01000002_gene1074	2.285e-97	333.0	28HWT@1|root,2Z82P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Xpo1
DYD2_k127_6406860_3	1382356.JQMP01000003_gene1636	2.766e-05	53.0	2APF3@1|root,31EHT@2|Bacteria,2G97G@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
DYD2_k127_6406860_1	1380347.JNII01000008_gene4121	6.964e-42	167.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4ESQB@85013|Frankiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
DYD2_k127_6406860_2	1288079.AUKN01000007_gene1863	2.46e-13	79.0	COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria	201174|Actinobacteria	K	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
DYD2_k127_6421767_1	1283299.AUKG01000001_gene1499	6.317e-38	146.0	COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria,4CQ70@84995|Rubrobacteria	84995|Rubrobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
DYD2_k127_6421767_3	292459.STH1026	9.38e-29	121.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia	186801|Clostridia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
DYD2_k127_6421767_4	316274.Haur_4759	3.559e-21	104.0	COG0526@1|root,COG0526@2|Bacteria,2GACV@200795|Chloroflexi,375FU@32061|Chloroflexia	32061|Chloroflexia	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
DYD2_k127_6421767_2	1121946.AUAX01000019_gene7777	2.276e-36	149.0	COG3340@1|root,COG3340@2|Bacteria,2ISWE@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
DYD2_k127_6421767_5	1449353.JQMQ01000005_gene4804	7.623e-08	61.0	2ERD0@1|root,33IYN@2|Bacteria,2GXC0@201174|Actinobacteria,2NJ2I@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6421767_0	1380347.JNII01000008_gene4226	1.995e-56	214.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4ERJ2@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
DYD2_k127_6421932_2	1089545.KB913037_gene5374	5.102e-05	52.0	COG2072@1|root,COG2072@2|Bacteria,2GNGX@201174|Actinobacteria,4E165@85010|Pseudonocardiales	201174|Actinobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
DYD2_k127_6421932_1	258052.JNYV01000003_gene4776	2.155e-25	111.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria,2M2YG@2063|Kitasatospora	201174|Actinobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
DYD2_k127_6421932_3	1229780.BN381_70025	0.0004679	46.0	28YVQ@1|root,2ZKNY@2|Bacteria,2HCMJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6421932_0	1206729.BAFZ01000124_gene3916	2.886e-87	294.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FVYV@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the thiolase family	fadA3	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_643415_1	909613.UO65_5101	7.064e-134	440.0	COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4E0R9@85010|Pseudonocardiales	201174|Actinobacteria	S	protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
DYD2_k127_643415_2	1463855.JOHV01000036_gene5798	2.732e-105	347.0	COG1878@1|root,COG1878@2|Bacteria,2GUSA@201174|Actinobacteria	201174|Actinobacteria	S	cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
DYD2_k127_643415_0	675635.Psed_4198	7.242e-176	561.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DZ1Z@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
DYD2_k127_643415_3	479432.Sros_6619	1.599e-95	320.0	COG0803@1|root,COG0803@2|Bacteria,2IAV8@201174|Actinobacteria,4EQ9A@85012|Streptosporangiales	201174|Actinobacteria	P	Domain of unknown function (DUF4437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4437
DYD2_k127_643415_4	1151117.AJLF01000001_gene985	1.544e-14	79.0	COG1487@1|root,arCOG02225@2157|Archaea,2Y6G6@28890|Euryarchaeota,244G3@183968|Thermococci	183968|Thermococci	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_644502_3	457570.Nther_2116	7.86e-21	102.0	COG3764@1|root,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
DYD2_k127_644502_2	1448389.BAVQ01000022_gene1613	1.477e-35	140.0	COG3467@1|root,COG3467@2|Bacteria,2IFJS@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
DYD2_k127_644502_5	290399.Arth_2921	4.291e-05	52.0	COG4961@1|root,COG4961@2|Bacteria,2GSXX@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
DYD2_k127_644502_4	644283.Micau_0224	2.704e-18	88.0	COG2452@1|root,COG2452@2|Bacteria,2GQJ9@201174|Actinobacteria,4DEVR@85008|Micromonosporales	201174|Actinobacteria	L	Helix-turn-helix domain	bldC	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DYD2_k127_644502_1	1408254.T458_17925	6.242e-96	323.0	COG0119@1|root,COG0119@2|Bacteria,1TQG3@1239|Firmicutes,4HA1U@91061|Bacilli,26TCB@186822|Paenibacillaceae	91061|Bacilli	E	Hydroxymethylglutaryl-CoA lyase	yngG	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
DYD2_k127_644502_0	292459.STH1579	8.712e-228	715.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,24BNG@186801|Clostridia	186801|Clostridia	I	Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
DYD2_k127_6449701_0	1089455.MOPEL_029_01240	1.801e-34	135.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4F69G@85018|Dermatophilaceae	201174|Actinobacteria	E	Glutamine synthetase, catalytic domain	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DYD2_k127_6449701_1	512565.AMIS_18740	1.229e-25	112.0	COG1595@1|root,COG1595@2|Bacteria,2IKUV@201174|Actinobacteria,4DDZM@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_6449701_2	76636.JOEC01000003_gene1727	4.026e-12	74.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4FMIE@85023|Microbacteriaceae	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
DYD2_k127_6464800_2	1380356.JNIK01000014_gene3476	2.627e-63	244.0	COG0577@1|root,COG0577@2|Bacteria,2GWZR@201174|Actinobacteria,4EVD8@85013|Frankiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
DYD2_k127_6464800_6	1162668.LFE_1399	1.219e-05	52.0	COG2331@1|root,COG2331@2|Bacteria,3J0V8@40117|Nitrospirae	40117|Nitrospirae	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
DYD2_k127_6464800_4	574087.Acear_0296	2.309e-23	104.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia,3WASA@53433|Halanaerobiales	186801|Clostridia	S	PFAM Uncharacterised BCR, COG1937	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
DYD2_k127_6464800_0	1121936.AUHI01000015_gene171	8.371e-179	578.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli	91061|Bacilli	IQ	Activates fatty acids by binding to coenzyme A	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
DYD2_k127_6464800_3	1122138.AQUZ01000078_gene6114	4.964e-27	116.0	COG3832@1|root,COG3832@2|Bacteria,2GSCI@201174|Actinobacteria,4DSI9@85009|Propionibacteriales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
DYD2_k127_6464800_1	1382306.JNIM01000001_gene2647	6.879e-72	247.0	COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi	200795|Chloroflexi	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DYD2_k127_6464800_5	411470.RUMGNA_03490	8.009e-17	87.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3XZC8@572511|Blautia	186801|Clostridia	KLT	Psort location CytoplasmicMembrane, score	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
DYD2_k127_6477433_1	348780.NP_4164A	6.208e-27	125.0	COG1506@1|root,arCOG01646@2157|Archaea,2Y7PF@28890|Euryarchaeota,23UFR@183963|Halobacteria	183963|Halobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S15,Peptidase_S9
DYD2_k127_6477433_0	1122609.AUGT01000026_gene61	7.139e-211	671.0	COG2355@1|root,COG2355@2|Bacteria,2HZ6F@201174|Actinobacteria,4DPCY@85009|Propionibacteriales	201174|Actinobacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6478614_2	243231.GSU0567	1.833e-72	255.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria,43SFH@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
DYD2_k127_6478614_0	1048339.KB913029_gene3185	1.728e-126	426.0	COG2159@1|root,COG2159@2|Bacteria,2H94T@201174|Actinobacteria,4EWGY@85013|Frankiales	201174|Actinobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6478614_1	675635.Psed_1114	2.436e-106	371.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4DXMZ@85010|Pseudonocardiales	201174|Actinobacteria	L	helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
DYD2_k127_6489215_5	877455.Metbo_1369	7.794e-26	115.0	COG2403@1|root,arCOG01230@2157|Archaea,2XVKW@28890|Euryarchaeota,23PAK@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	-
DYD2_k127_6489215_3	869210.Marky_1499	8.761e-60	226.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	AAA_33,ATP-cone
DYD2_k127_6489215_0	1288083.AUKR01000002_gene4563	3.547e-150	496.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
DYD2_k127_6489215_4	411471.SUBVAR_05136	1.871e-29	118.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
DYD2_k127_6489215_2	1449126.JQKL01000005_gene842	4.469e-73	261.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,2683Y@186813|unclassified Clostridiales	186801|Clostridia	S	Protein of unknown function (DUF1385)	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
DYD2_k127_6489215_1	858215.Thexy_2197	2.044e-89	303.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
DYD2_k127_650434_0	68219.JNXI01000003_gene4425	1.249e-184	584.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	paaJ	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_650434_1	997346.HMPREF9374_3357	9.616e-171	569.0	COG2366@1|root,COG2366@2|Bacteria,1VTGK@1239|Firmicutes,4HUFQ@91061|Bacilli	91061|Bacilli	S	Penicillin amidase	-	-	-	-	-	-	-	-	-	-	-	-	Penicil_amidase
DYD2_k127_650434_2	1304865.JAGF01000001_gene1043	7.246e-17	94.0	COG3119@1|root,COG3119@2|Bacteria,2H59R@201174|Actinobacteria,4F222@85016|Cellulomonadaceae	201174|Actinobacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_650485_1	649638.Trad_2776	3.147e-28	118.0	COG3346@1|root,COG3346@2|Bacteria	2|Bacteria	S	mitochondrial respiratory chain complex IV assembly	surf1	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
DYD2_k127_650485_0	1229780.BN381_240011	1.086e-87	302.0	COG0258@1|root,COG0258@2|Bacteria,2H2A3@201174|Actinobacteria	201174|Actinobacteria	L	5'-3' exonuclease, C-terminal SAM fold	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
DYD2_k127_650485_2	1128421.JAGA01000003_gene2765	7.182e-22	109.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_6514140_4	1150864.MILUP08_46074	1.474e-76	273.0	COG0612@1|root,COG0612@2|Bacteria,2GKAT@201174|Actinobacteria,4DBWR@85008|Micromonosporales	201174|Actinobacteria	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DYD2_k127_6514140_2	1123023.JIAI01000003_gene2883	5.82e-129	425.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4DYFI@85010|Pseudonocardiales	201174|Actinobacteria	S	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
DYD2_k127_6514140_3	1313172.YM304_09460	5.981e-84	297.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4CNZW@84992|Acidimicrobiia	201174|Actinobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
DYD2_k127_6514140_1	335543.Sfum_0727	2.969e-139	479.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2MRAX@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter Family	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
DYD2_k127_6514140_5	1121928.AUHE01000002_gene439	5.83e-46	168.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,4GE59@85026|Gordoniaceae	201174|Actinobacteria	K	Nitrogen regulatory protein P-II	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
DYD2_k127_6514140_7	485913.Krac_2293	5.361e-08	62.0	COG3340@1|root,COG3340@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
DYD2_k127_6514140_0	469383.Cwoe_2194	3.243e-156	502.0	COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria,4CSWE@84995|Rubrobacteria	84995|Rubrobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
DYD2_k127_6514140_6	1440053.JOEI01000011_gene4668	8.537e-19	96.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
DYD2_k127_6516555_1	188626.HMPREF0321_2775	9.566e-14	70.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,1ZVDE@145357|Dermacoccaceae	201174|Actinobacteria	I	Thiolase, C-terminal domain	fadA4	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_6516555_0	1122138.AQUZ01000015_gene6845	1.439e-79	280.0	COG0477@1|root,COG2814@2|Bacteria,2I8HS@201174|Actinobacteria,4DVK7@85009|Propionibacteriales	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
DYD2_k127_6516555_2	7739.XP_002588815.1	4.343e-06	58.0	COG0457@1|root,KOG0548@2759|Eukaryota,38GAN@33154|Opisthokonta,3BEXQ@33208|Metazoa,3CSRU@33213|Bilateria	33208|Metazoa	O	regulation of mitotic cell cycle	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,DED,TPR_10,TPR_12,TPR_2,TPR_7,TPR_8
DYD2_k127_6528675_8	1125863.JAFN01000001_gene1869	8.088e-24	107.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
DYD2_k127_6528675_1	1033738.CAEP01000041_gene817	2.777e-121	399.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,4HAVN@91061|Bacilli,26DG1@186818|Planococcaceae	91061|Bacilli	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
DYD2_k127_6528675_3	436229.JOEH01000040_gene6437	3.253e-73	267.0	COG0642@1|root,COG2205@2|Bacteria,2GMB9@201174|Actinobacteria,2NFV4@228398|Streptacidiphilus	201174|Actinobacteria	T	PAS fold	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
DYD2_k127_6528675_10	882083.SacmaDRAFT_3492	1.448e-14	84.0	COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4DX6V@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	tsnR	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
DYD2_k127_6528675_5	543632.JOJL01000026_gene2434	2.288e-45	168.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4DDFK@85008|Micromonosporales	201174|Actinobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
DYD2_k127_6528675_9	526225.Gobs_3038	3.878e-16	81.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4ETHR@85013|Frankiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
DYD2_k127_6528675_4	469371.Tbis_2042	4.968e-69	238.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4DYUF@85010|Pseudonocardiales	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
DYD2_k127_6528675_7	404589.Anae109_2532	5.489e-25	105.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2Z1SJ@29|Myxococcales	28221|Deltaproteobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
DYD2_k127_6528675_2	471852.Tcur_2993	1.524e-101	339.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4EGFE@85012|Streptosporangiales	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
DYD2_k127_6528675_6	408672.NBCG_02645	2.26e-31	134.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria,4DQTS@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
DYD2_k127_6528675_0	1089553.Tph_c14030	4.169e-153	494.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,42FC2@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
DYD2_k127_6540025_2	932213.SPM24T3_04007	0.0005924	53.0	COG3210@1|root,COG3420@1|root,COG4932@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,1QUXB@1224|Proteobacteria,1T24R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
DYD2_k127_6540025_1	593105.S7A_06540	0.0004501	53.0	COG2373@1|root,COG2911@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,3VXVZ@53335|Pantoea	1236|Gammaproteobacteria	M	PFAM FecR protein	yeeJ	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
DYD2_k127_6540025_3	105425.BBPL01000012_gene1910	0.0008796	48.0	2E3V5@1|root,34A4T@2|Bacteria,2HP36@201174|Actinobacteria,2NJEZ@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6540025_0	351607.Acel_0801	2e-323	1007.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DYD2_k127_6565381_7	103733.JNYO01000044_gene6638	1.574e-28	122.0	COG1595@1|root,COG1595@2|Bacteria,2IC8V@201174|Actinobacteria,4E48R@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_6565381_5	469371.Tbis_1395	3.291e-57	224.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4E181@85010|Pseudonocardiales	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
DYD2_k127_6565381_6	1122182.KB903833_gene5254	2.359e-32	141.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4DB81@85008|Micromonosporales	201174|Actinobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_6565381_3	479433.Caci_8515	1.671e-109	363.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_6565381_0	1048339.KB913029_gene998	2.557e-139	452.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4ES7N@85013|Frankiales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA2	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_6565381_1	1037409.BJ6T_56240	1.581e-133	440.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,3JTK8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc,Hydrolase_4,Trans_reg_C
DYD2_k127_6565381_4	1463825.JNXC01000010_gene2755	3.593e-63	228.0	COG0189@1|root,COG0189@2|Bacteria,2HI2Z@201174|Actinobacteria,4DXM1@85010|Pseudonocardiales	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
DYD2_k127_6565381_2	196162.Noca_2748	4.817e-117	392.0	COG0613@1|root,COG0613@2|Bacteria,2IDTP@201174|Actinobacteria	201174|Actinobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
DYD2_k127_6570735_1	700508.D174_05460	3.359e-18	97.0	COG5340@1|root,COG5340@2|Bacteria,2I4J9@201174|Actinobacteria,23F94@1762|Mycobacteriaceae	201174|Actinobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
DYD2_k127_6570735_0	1278078.G419_10171	6.495e-111	362.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4FUIR@85025|Nocardiaceae	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
DYD2_k127_6587188_0	1449069.JMLO01000003_gene4078	7.255e-90	307.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4FWCQ@85025|Nocardiaceae	201174|Actinobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
DYD2_k127_6587188_1	66429.JOFL01000021_gene5702	1.914e-85	293.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
DYD2_k127_6587188_3	42256.RradSPS_2482	8.623e-24	115.0	2BIEE@1|root,30G98@2|Bacteria,2I86Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6587188_2	710111.FraQA3DRAFT_4233	2.754e-75	259.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria,4ESKD@85013|Frankiales	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
DYD2_k127_6588872_2	324602.Caur_1594	1.484e-14	86.0	COG0438@1|root,COG0438@2|Bacteria,2G6AR@200795|Chloroflexi,376SQ@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_6588872_0	1144275.COCOR_00974	1.368e-32	146.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2YTU8@29|Myxococcales	28221|Deltaproteobacteria	D	protein involved in exopolysaccharide biosynthesis	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
DYD2_k127_6588872_4	164757.Mjls_1310	0.00014	49.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,234DY@1762|Mycobacteriaceae	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
DYD2_k127_6588872_3	590998.Celf_2275	1.057e-08	64.0	COG0789@1|root,COG0789@2|Bacteria,2I3PS@201174|Actinobacteria	201174|Actinobacteria	K	TIGRFAM DNA binding domain protein, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DYD2_k127_6588872_1	591159.ACEZ01000204_gene6390	8.8e-19	98.0	COG3409@1|root,COG3591@1|root,COG3409@2|Bacteria,COG3591@2|Bacteria,2IDIJ@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
DYD2_k127_6704642_2	1123023.JIAI01000006_gene141	1.53e-21	96.0	COG0500@1|root,COG2226@2|Bacteria,2HIHA@201174|Actinobacteria,4DY0M@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DYD2_k127_6704642_1	1445613.JALM01000006_gene573	2.433e-66	233.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria,4DZBZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
DYD2_k127_6704642_0	1089553.Tph_c09080	7.919e-84	289.0	COG0297@1|root,COG0297@2|Bacteria,1UHYC@1239|Firmicutes,24ANR@186801|Clostridia,42FS8@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Glycosyl transferase, group 1	-	-	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_6718659_1	399549.Msed_0592	2.401e-05	57.0	COG1361@1|root,arCOG02089@2157|Archaea,2XR0S@28889|Crenarchaeota	28889|Crenarchaeota	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6718659_0	1869.MB27_35525	5.82e-31	135.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4D8TU@85008|Micromonosporales	201174|Actinobacteria	V	MacB-like periplasmic core domain	yknZ	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
DYD2_k127_672850_4	1050202.KB913024_gene1305	6.822e-05	54.0	COG0515@1|root,COG0515@2|Bacteria,2GJTV@201174|Actinobacteria,409NI@622450|Actinopolysporales	201174|Actinobacteria	KLT	Protein kinase domain	pkaE	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
DYD2_k127_672850_2	318424.EU78_04450	1.05e-56	205.0	COG1716@1|root,COG1716@2|Bacteria,2HPF7@201174|Actinobacteria,2351W@1762|Mycobacteriaceae	201174|Actinobacteria	T	Fha domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,FHA
DYD2_k127_672850_1	1128421.JAGA01000003_gene2765	1.25e-61	231.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
DYD2_k127_672850_5	469383.Cwoe_1816	0.0007044	46.0	COG0438@1|root,COG0438@2|Bacteria,2GR58@201174|Actinobacteria,4CPE6@84995|Rubrobacteria	84995|Rubrobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_672850_0	1120950.KB892756_gene6665	1.956e-73	252.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4DQ2S@85009|Propionibacteriales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DYD2_k127_672850_3	1394178.AWOO02000014_gene7811	1.551e-20	92.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4EJI6@85012|Streptosporangiales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
DYD2_k127_674976_0	1048339.KB913029_gene4038	4.631e-76	276.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria,4EUV2@85013|Frankiales	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
DYD2_k127_71291_3	1121877.JQKF01000024_gene2404	1.147e-42	158.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CMZZ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
DYD2_k127_71291_4	1177594.MIC448_390074	3.254e-20	96.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4FNSQ@85023|Microbacteriaceae	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
DYD2_k127_71291_2	1123320.KB889665_gene1430	1.98e-60	215.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
DYD2_k127_71291_0	477641.MODMU_3324	9.638e-120	398.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4ES0C@85013|Frankiales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DYD2_k127_71291_1	196162.Noca_2429	2.571e-81	279.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4DMZJ@85009|Propionibacteriales	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
DYD2_k127_71537_0	886293.Sinac_1689	8.76e-115	374.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
DYD2_k127_71537_1	479434.Sthe_2381	4.135e-73	256.0	COG0365@1|root,COG0365@2|Bacteria,2G830@200795|Chloroflexi,27XH3@189775|Thermomicrobia	189775|Thermomicrobia	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
DYD2_k127_71537_5	391616.OA238_c11750	0.0008715	51.0	COG3794@1|root,COG3794@2|Bacteria,1NM0N@1224|Proteobacteria,2UKBR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
DYD2_k127_71537_3	163908.KB235896_gene3036	2.125e-36	145.0	COG4122@1|root,COG4122@2|Bacteria,1G8BJ@1117|Cyanobacteria	1117|Cyanobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
DYD2_k127_71537_4	545695.TREAZ_0858	2.222e-23	111.0	COG2227@1|root,COG2227@2|Bacteria,2J6CB@203691|Spirochaetes	203691|Spirochaetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
DYD2_k127_71537_2	670487.Ocepr_0952	3.116e-48	175.0	COG0114@1|root,COG0114@2|Bacteria,1WJ9Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
DYD2_k127_729345_1	1122612.AUBA01000026_gene3165	3.603e-06	59.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,2K5WP@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
DYD2_k127_729345_0	1394178.AWOO02000009_gene4304	2.768e-08	65.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4EG2X@85012|Streptosporangiales	201174|Actinobacteria	EH	Thiamine pyrophosphate enzyme, central domain	ilvB2	GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.2.1.6,4.1.1.7	ko:K01576,ko:K01652	ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648	RC00027,RC00106,RC00595,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DYD2_k127_742222_0	43354.JOIJ01000002_gene4135	1.182e-73	258.0	COG0204@1|root,COG0204@2|Bacteria,2GKM6@201174|Actinobacteria,4E09D@85010|Pseudonocardiales	201174|Actinobacteria	I	Phosphate acyltransferases	plsC1	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
DYD2_k127_742222_2	429009.Adeg_0989	4.279e-25	116.0	COG1341@1|root,COG1341@2|Bacteria	2|Bacteria	S	polynucleotide 5'-hydroxyl-kinase activity	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
DYD2_k127_742222_3	1121355.KB903376_gene920	2.325e-13	72.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,22P4W@1653|Corynebacteriaceae	201174|Actinobacteria	K	DNA binding domain, excisionase family	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
DYD2_k127_742222_1	1449353.JQMQ01000005_gene4150	2.157e-28	119.0	2EWNZ@1|root,33Q0W@2|Bacteria,2GJYE@201174|Actinobacteria,2NES4@228398|Streptacidiphilus	201174|Actinobacteria	S	Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphatase
DYD2_k127_761567_1	246197.MXAN_5479	1.774e-14	74.0	COG0110@1|root,COG0110@2|Bacteria,1RA2T@1224|Proteobacteria,42T5H@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
DYD2_k127_761567_0	1183438.GKIL_3469	8.682e-35	146.0	COG1216@1|root,COG1216@2|Bacteria,1G2HS@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferase, family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
DYD2_k127_763011_3	479435.Kfla_1652	3.297e-41	161.0	COG1011@1|root,COG1011@2|Bacteria,2I8XE@201174|Actinobacteria,4DV7B@85009|Propionibacteriales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025,ko:K18569	ko00332,ko01130,map00332,map01130	-	R10748	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
DYD2_k127_763011_4	1121877.JQKF01000003_gene1451	1.417e-24	115.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4CN6V@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
DYD2_k127_763011_1	1137269.AZWL01000005_gene2437	3.059e-66	231.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	cypB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
DYD2_k127_763011_2	67352.JODS01000025_gene3139	3.051e-46	178.0	COG2141@1|root,COG2141@2|Bacteria,2HVKH@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_763011_0	926569.ANT_11950	1.037e-130	434.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi	200795|Chloroflexi	H	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
DYD2_k127_763011_5	867845.KI911784_gene3008	4.046e-05	47.0	COG0318@1|root,COG0318@2|Bacteria,2G5K4@200795|Chloroflexi,3758A@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
DYD2_k127_763680_3	867903.ThesuDRAFT_00213	7.552e-19	96.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,3WCHZ@538999|Clostridiales incertae sedis	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
DYD2_k127_763680_0	643648.Slip_0897	2.083e-97	329.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42JJA@68298|Syntrophomonadaceae	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
DYD2_k127_763680_2	754252.PFREUD_18020	5.095e-23	103.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria	201174|Actinobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
DYD2_k127_763680_1	335541.Swol_1864	8.989e-27	116.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,42K57@68298|Syntrophomonadaceae	186801|Clostridia	H	5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
DYD2_k127_783764_0	1184609.KILIM_008_00150	6.034e-72	246.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4F7J7@85018|Dermatophilaceae	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
DYD2_k127_783764_3	1237500.ANBA01000012_gene5195	4.487e-48	188.0	COG0477@1|root,COG2814@2|Bacteria,2I3P4@201174|Actinobacteria,4EGM4@85012|Streptosporangiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_783764_1	1229780.BN381_50095	4.507e-61	221.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria	201174|Actinobacteria	K	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
DYD2_k127_783764_2	1116472.MGMO_45c00700	1.702e-48	182.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,1XEI4@135618|Methylococcales	135618|Methylococcales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
DYD2_k127_802046_0	298653.Franean1_7308	6.18e-137	449.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4ERFB@85013|Frankiales	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
DYD2_k127_802046_1	1042877.GQS_06370	2.373e-24	113.0	COG0697@1|root,arCOG00271@2157|Archaea,2Y0E3@28890|Euryarchaeota,243J7@183968|Thermococci	183968|Thermococci	G	Drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_82953_3	1121101.HMPREF1532_03733	0.0001946	54.0	COG1361@1|root,COG1520@1|root,COG4870@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG4870@2|Bacteria,4NVQ3@976|Bacteroidetes,2G321@200643|Bacteroidia,4ATRZ@815|Bacteroidaceae	976|Bacteroidetes	MO	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25,VCBS
DYD2_k127_82953_0	37919.EP51_23975	1.783e-34	146.0	COG3835@1|root,COG3835@2|Bacteria,2IH2D@201174|Actinobacteria,4FZXX@85025|Nocardiaceae	201174|Actinobacteria	KT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
DYD2_k127_82953_2	1123320.KB889566_gene5765	2.533e-05	48.0	COG3835@1|root,COG3835@2|Bacteria,2IH2D@201174|Actinobacteria	201174|Actinobacteria	KT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
DYD2_k127_82953_1	1283299.AUKG01000001_gene1656	1.229e-06	61.0	COG1073@1|root,COG1073@2|Bacteria,2IBGB@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_846794_2	1048339.KB913029_gene1087	2.255e-08	59.0	2E73B@1|root,331MU@2|Bacteria,2IFR6@201174|Actinobacteria	1048339.KB913029_gene1087|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_846794_0	675635.Psed_3999	7.865e-71	250.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4DY08@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_849685_10	1282360.ABAC460_15060	5.836e-18	93.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_849685_8	419947.MRA_3732	1.802e-30	132.0	COG1848@1|root,COG1848@2|Bacteria,2IPKR@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
DYD2_k127_849685_11	419947.MRA_3733	2.398e-10	64.0	2A15A@1|root,30PB5@2|Bacteria,2HCF1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_849685_0	234267.Acid_5780	5.784e-160	555.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_8,Trans_reg_C
DYD2_k127_849685_3	667014.Thein_0743	4.405e-76	262.0	COG0217@1|root,COG0217@2|Bacteria,2GHCG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
DYD2_k127_849685_6	749414.SBI_02400	5.003e-56	201.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
DYD2_k127_849685_1	1120950.KB892708_gene4269	1.732e-138	446.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4DNEB@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
DYD2_k127_849685_2	1313172.YM304_19800	1.11e-82	288.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4CNA7@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
DYD2_k127_849685_5	1047013.AQSP01000139_gene2393	2.557e-59	222.0	COG1704@1|root,COG1704@2|Bacteria,2NPIW@2323|unclassified Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DYD2_k127_849685_4	1172186.KB911467_gene1995	2.066e-69	250.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,235A2@1762|Mycobacteriaceae	201174|Actinobacteria	M	GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
DYD2_k127_849685_7	1121926.AXWO01000013_gene2105	2.031e-52	197.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4EYCM@85014|Glycomycetales	201174|Actinobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
DYD2_k127_849685_9	1313172.YM304_19750	1.248e-26	117.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CN1P@84992|Acidimicrobiia	84992|Acidimicrobiia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DYD2_k127_897829_3	35754.JNYJ01000062_gene1481	2.387e-24	105.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4DCS2@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
DYD2_k127_897829_0	1027371.GOALK_108_00080	7.501e-183	578.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4GCU4@85026|Gordoniaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_897829_2	479432.Sros_6630	9.84e-30	133.0	COG1545@1|root,COG1545@2|Bacteria,2GTB8@201174|Actinobacteria	201174|Actinobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
DYD2_k127_897829_1	479432.Sros_6629	2.722e-160	515.0	COG0183@1|root,COG0183@2|Bacteria,2GKH4@201174|Actinobacteria,4EIRT@85012|Streptosporangiales	201174|Actinobacteria	I	Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
DYD2_k127_921314_0	1048339.KB913029_gene4038	1.75e-57	222.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria,4EUV2@85013|Frankiales	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
DYD2_k127_921314_2	1048339.KB913029_gene4039	7.796e-13	80.0	2FACV@1|root,342M7@2|Bacteria,2H6AW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_921314_1	1206741.BAFX01000043_gene3191	2.286e-41	158.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4FZ49@85025|Nocardiaceae	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
DYD2_k127_923792_0	656024.FsymDg_2435	1.278e-25	115.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria,4ET6R@85013|Frankiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
DYD2_k127_923792_1	591158.SSMG_06426	1.373e-13	76.0	2C7XW@1|root,32RR4@2|Bacteria,2IQ5R@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3499
DYD2_k127_923792_2	1382306.JNIM01000001_gene1584	1.391e-11	74.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
DYD2_k127_923792_3	1127134.NOCYR_0944	0.0001684	50.0	2F0NR@1|root,33TR6@2|Bacteria,2GUJF@201174|Actinobacteria,4G0W4@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_924595_2	471852.Tcur_2297	6.22e-91	309.0	COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4EFUB@85012|Streptosporangiales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DYD2_k127_924595_1	350058.Mvan_0435	2.841e-118	389.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,233DE@1762|Mycobacteriaceae	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DYD2_k127_924595_0	1449353.JQMQ01000005_gene2106	3.716e-139	451.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,2NEE4@228398|Streptacidiphilus	201174|Actinobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DYD2_k127_98661_7	351607.Acel_1202	5.811e-19	90.0	2BZPH@1|root,33EX8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_98661_1	710111.FraQA3DRAFT_5145	0.0	1097.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4ES4C@85013|Frankiales	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
DYD2_k127_98661_4	591159.ACEZ01000207_gene6946	9.158e-55	207.0	COG1846@1|root,COG1846@2|Bacteria,2GMDI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_98661_5	1449346.JQMO01000002_gene929	5.163e-47	181.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,2M0NW@2063|Kitasatospora	201174|Actinobacteria	L	Formamidopyrimidine-DNA glycosylase N-terminal domain	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
DYD2_k127_98661_0	469371.Tbis_2890	0.0	1320.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4DYC3@85010|Pseudonocardiales	201174|Actinobacteria	C	Dehydrogenase E1 component	kgd	-	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
DYD2_k127_98661_2	500635.MITSMUL_03546	4.267e-120	413.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H360@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding Protein	pbpD	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
DYD2_k127_98661_3	350058.Mvan_2384	4.816e-113	379.0	COG0596@1|root,COG0596@2|Bacteria,2GKJB@201174|Actinobacteria,23F6M@1762|Mycobacteriaceae	201174|Actinobacteria	S	Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons	dhmA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
DYD2_k127_98661_6	1380356.JNIK01000015_gene2514	1.983e-19	96.0	COG3103@1|root,COG5479@1|root,COG4991@2|Bacteria,COG5479@2|Bacteria,2GN2D@201174|Actinobacteria,4EX5K@85013|Frankiales	201174|Actinobacteria	M	LGFP repeat	-	-	-	-	-	-	-	-	-	-	-	-	LGFP
DYD2_k127_998104_11	1246995.AFR_21060	4.178e-24	109.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4DAQQ@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
DYD2_k127_998104_0	1382306.JNIM01000001_gene1224	1.705e-212	689.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2G65W@200795|Chloroflexi	200795|Chloroflexi	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
DYD2_k127_998104_7	298653.Franean1_4998	2.843e-40	153.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4ESYX@85013|Frankiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
DYD2_k127_998104_6	471852.Tcur_2434	2.786e-42	160.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4EJ30@85012|Streptosporangiales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
DYD2_k127_998104_8	351607.Acel_1225	9.909e-40	160.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4ESMT@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MerR	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
DYD2_k127_998104_3	42256.RradSPS_1974	8.006e-62	219.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4CPVX@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
DYD2_k127_998104_4	351607.Acel_1224	1.457e-46	173.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4ESIT@85013|Frankiales	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
DYD2_k127_998104_5	1312959.KI914655_gene687	4.707e-43	162.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,1W7XU@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
DYD2_k127_998104_9	671143.DAMO_2813	2.008e-35	141.0	COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria	2|Bacteria	F	Cytidylate kinase-like family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
DYD2_k127_998104_12	316274.Haur_0199	1.29e-23	108.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	dinB	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB
DYD2_k127_998104_2	530564.Psta_4671	1.897e-121	410.0	COG0403@1|root,COG0403@2|Bacteria,2IXNG@203682|Planctomycetes	203682|Planctomycetes	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
DYD2_k127_998104_1	1123252.ATZF01000001_gene1298	2.824e-181	581.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,4HB80@91061|Bacilli,27BIK@186824|Thermoactinomycetaceae	91061|Bacilli	E	Glycine cleavage system P-protein	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
DYD2_k127_998104_10	479432.Sros_2015	4.587e-26	112.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria,4EP3S@85012|Streptosporangiales	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
DYD2_k127_998104_13	1435356.Y013_12475	1.507e-09	63.0	COG2141@1|root,COG2141@2|Bacteria,2GN4N@201174|Actinobacteria,4G8SR@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
## 1999 queries scanned
## Total time (seconds): 13.524263143539429
## Rate: 147.81 q/s