## Sun Mar 16 13:27:42 2025
## emapper-2.1.9
## /home/zhangkaihang/.conda/envs/eggnog-mapper/bin/emapper.py -i /home/zhangkaihang/metadata_analysis/metawrap/paddysoil/4paddy/bin4gtdbtk/DYD2_bin.46.fa -m mmseqs --itype genome -o DYD2_bin.46 --output_dir /home/zhangkaihang/metadata_analysis/eggnog-mapper/paddysoil/4paddy/DYD2_bin.46 --cpu 8
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
DYD2_k127_1018058_2	436308.Nmar_1009	0.0002154	52.0	arCOG10568@1|root,arCOG10568@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1018058_0	571166.KI421509_gene1518	1.962e-06	59.0	COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2U7B2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	putR	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
DYD2_k127_1018058_1	523791.Kkor_1812	0.0001097	54.0	COG3291@1|root,COG4412@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria,1PFDE@1224|Proteobacteria,1RWU9@1236|Gammaproteobacteria,1XNU8@135619|Oceanospirillales	135619|Oceanospirillales	M	PKD domain	-	-	3.2.1.91	ko:K09607,ko:K19668	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R02886,R11308	RC00799	ko00000,ko00001,ko01000,ko01002	-	GH6	-	PKD
DYD2_k127_1083954_4	673860.AciM339_0523	2.317e-73	274.0	COG0463@1|root,arCOG00894@2157|Archaea,2XUJ6@28890|Euryarchaeota,3F38U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_1083954_3	439481.Aboo_0519	1.675e-99	332.0	COG0463@1|root,arCOG01385@2157|Archaea,2XUEP@28890|Euryarchaeota,3F30S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	aglI	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_1083954_11	1124780.ANNU01000021_gene2983	8.541e-26	124.0	COG2244@1|root,COG2244@2|Bacteria,4PBQX@976|Bacteroidetes,47W6P@768503|Cytophagia	976|Bacteroidetes	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1083954_13	1229780.BN381_10222	1.22e-23	117.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	wbpZ	-	2.4.1.348,2.4.1.87	ko:K00743,ko:K12995	ko00601,map00601	-	R05978,R06169	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT4,GT6	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_1083954_20	797210.Halxa_2989	6.427e-12	73.0	COG1487@1|root,arCOG02219@2157|Archaea,2XX7I@28890|Euryarchaeota,23VMN@183963|Halobacteria	183963|Halobacteria	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_1083954_22	224325.AF_1478	1.42e-06	52.0	COG1753@1|root,arCOG02681@2157|Archaea	2157|Archaea	S	Possibly the antitoxin component of a	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
DYD2_k127_1083954_0	1041930.Mtc_1395	5.301e-243	757.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2N97D@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
DYD2_k127_1083954_14	331678.Cphamn1_0872	1.352e-21	102.0	COG2361@1|root,COG2361@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
DYD2_k127_1083954_16	65393.PCC7424_0998	7.195e-16	81.0	COG1669@1|root,COG1669@2|Bacteria,1G804@1117|Cyanobacteria,3KK82@43988|Cyanothece	1117|Cyanobacteria	L	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
DYD2_k127_1083954_21	1459636.NTE_00271	2.082e-11	70.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
DYD2_k127_1083954_23	397278.JOJN01000012_gene2144	1.508e-05	59.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
DYD2_k127_1083954_15	246197.MXAN_7458	1.399e-21	112.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	ko:K07114,ko:K07169,ko:K12065	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3,3.A.7.11.1	-	-	-
DYD2_k127_1083954_2	706587.Desti_0547	1.969e-118	395.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2MQ8E@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
DYD2_k127_1083954_1	693661.Arcve_1203	3.449e-120	412.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
DYD2_k127_1083954_5	439481.Aboo_0493	5.023e-53	196.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,3F2NN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	trm56	GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
DYD2_k127_1083954_9	1429916.X566_18685	5.7e-28	119.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria,3K67U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
DYD2_k127_1083954_7	1054217.TALC_01532	1.517e-34	138.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,241R5@183967|Thermoplasmata	183967|Thermoplasmata	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
DYD2_k127_1083954_25	1134445.AJJM01000033_gene3833	0.0006004	52.0	COG3595@1|root,COG3595@2|Bacteria,2I8IR@201174|Actinobacteria	201174|Actinobacteria	T	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
DYD2_k127_1083954_24	1136417.AZWE01000053_gene3990	0.0005863	49.0	COG0494@1|root,COG0494@2|Bacteria,2GS19@201174|Actinobacteria,4DFIG@85008|Micromonosporales	201174|Actinobacteria	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_1083954_18	130081.XP_005706286.1	6.026e-14	75.0	COG2154@1|root,KOG4073@2759|Eukaryota	2759|Eukaryota	H	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0008124,GO:0016829,GO:0016835,GO:0016836,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
DYD2_k127_1083954_6	1236689.MMALV_03070	6.999e-49	188.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,3F2TS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Calcineurin-like phosphoesterase superfamily domain	rpe	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
DYD2_k127_1083954_19	1038869.AXAN01000022_gene1901	3.023e-13	82.0	COG4409@1|root,COG4409@2|Bacteria,1Q513@1224|Proteobacteria,2WB3C@28216|Betaproteobacteria,1K536@119060|Burkholderiaceae	28216|Betaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1083954_10	351160.RCIX1292	6.184e-28	119.0	COG1695@1|root,arCOG00001@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DYD2_k127_1083954_12	304371.MCP_1786	1.86e-25	115.0	COG1714@1|root,arCOG03633@2157|Archaea	2157|Archaea	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
DYD2_k127_1083954_8	1144342.PMI40_02056	5.148e-30	138.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,476H0@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	UvrD-like helicase C-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
DYD2_k127_1132590_9	673860.AciM339_0768	3.656e-59	211.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,3F2MF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
DYD2_k127_1132590_2	1448860.BBJO01000055_gene82	1.367e-142	470.0	COG1012@1|root,arCOG01252@2157|Archaea,2XVV5@28890|Euryarchaeota,23U7E@183963|Halobacteria	183963|Halobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
DYD2_k127_1132590_13	1089548.KI783301_gene1259	1.817e-30	136.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4H9P6@91061|Bacilli,3WEEU@539002|Bacillales incertae sedis	91061|Bacilli	H	Lipoate--protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
DYD2_k127_1132590_14	565033.GACE_1930	1.34e-11	79.0	arCOG07536@1|root,arCOG07536@2157|Archaea,2Y13E@28890|Euryarchaeota,2474N@183980|Archaeoglobi	183980|Archaeoglobi	P	cobalamin transport	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1132590_6	349124.Hhal_0116	1.08e-94	319.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
DYD2_k127_1132590_4	673860.AciM339_0074	3.923e-122	404.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,3F2F9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Beta-Casp domain	epf1	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
DYD2_k127_1132590_1	234267.Acid_5088	2.06e-198	631.0	COG1012@1|root,COG1012@2|Bacteria,3Y3CY@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DYD2_k127_1132590_8	1382304.JNIL01000001_gene632	2.241e-80	287.0	COG4448@1|root,COG4448@2|Bacteria,1TRWI@1239|Firmicutes,4HAM1@91061|Bacilli,27A7C@186823|Alicyclobacillaceae	91061|Bacilli	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
DYD2_k127_1132590_11	1123368.AUIS01000006_gene626	3.85e-44	175.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation	ymdB	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231	-	-	-	-	-	-	-	-	-	-	Macro
DYD2_k127_1132590_0	867845.KI911784_gene1034	1.264e-242	768.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi,374UI@32061|Chloroflexia	32061|Chloroflexia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
DYD2_k127_1132590_7	351160.RRC285	6.18e-81	282.0	COG0598@1|root,arCOG02265@2157|Archaea	2157|Archaea	P	Mediates influx of magnesium ions	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DYD2_k127_1132590_10	795797.C497_10478	2.184e-55	211.0	COG0719@1|root,arCOG01715@2157|Archaea,2XU1H@28890|Euryarchaeota,23SSI@183963|Halobacteria	183963|Halobacteria	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB2	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
DYD2_k127_1132590_3	1457250.BBMO01000001_gene1665	2.088e-140	483.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,23T5E@183963|Halobacteria	183963|Halobacteria	E	COG0520 Selenocysteine lyase	sufS1	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
DYD2_k127_1132590_12	867903.ThesuDRAFT_00396	2.576e-35	153.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,3WCNM@538999|Clostridiales incertae sedis	186801|Clostridia	C	NifU-like N terminal domain	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
DYD2_k127_1132590_5	1120973.AQXL01000088_gene3235	8.338e-95	321.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,4HAD9@91061|Bacilli,277VM@186823|Alicyclobacillaceae	91061|Bacilli	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
DYD2_k127_1132590_16	362976.HQ_1571A	0.0005704	52.0	COG1238@1|root,arCOG03118@2157|Archaea,2XWI8@28890|Euryarchaeota,23VA4@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DYD2_k127_1132590_15	240292.Ava_2183	0.0005608	53.0	COG2319@1|root,COG4249@1|root,COG5635@1|root,COG2319@2|Bacteria,COG4249@2|Bacteria,COG5635@2|Bacteria,1FZVW@1117|Cyanobacteria,1HMS2@1161|Nostocales	1117|Cyanobacteria	T	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Pentapeptide,WD40
DYD2_k127_1151912_0	760568.Desku_3292	6.943e-169	545.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,2602C@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
DYD2_k127_1151912_4	694440.JOMF01000006_gene369	1.266e-28	125.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
DYD2_k127_1151912_3	1054217.TALC_01274	1.393e-53	203.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,241QV@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
DYD2_k127_1151912_2	1094980.Mpsy_1566	5.433e-65	234.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
DYD2_k127_1151912_1	246197.MXAN_3630	1.486e-82	287.0	COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria	1224|Proteobacteria	Q	polyketide synthase	-	-	-	ko:K04786	ko01053,map01053	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt
DYD2_k127_1169347_3	1094980.Mpsy_2686	8.701e-11	75.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
DYD2_k127_1169347_2	398511.BpOF4_18470	1.046e-15	90.0	COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,4HBJX@91061|Bacilli,1ZE6M@1386|Bacillus	91061|Bacilli	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_1169347_0	273116.14324238	2.996e-155	504.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2421R@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DYD2_k127_1169347_1	1054217.TALC_00915	5.407e-49	185.0	COG1986@1|root,arCOG01221@2157|Archaea,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota	28890|Euryarchaeota	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DYD2_k127_1203243_2	913325.N799_02615	4.025e-29	134.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales	135614|Xanthomonadales	KL	Helicase	yoaA	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,ResIII
DYD2_k127_1203243_4	1122223.KB890700_gene2106	0.0007585	46.0	COG2217@1|root,COG2217@2|Bacteria,1WJ55@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacS	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DYD2_k127_1203243_0	1122134.KB893650_gene158	2.968e-158	514.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1XH25@135619|Oceanospirillales	135619|Oceanospirillales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
DYD2_k127_1203243_3	572546.Arcpr_0076	8.707e-21	105.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DYD2_k127_1203243_1	1236689.MMALV_11680	1.863e-53	192.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y6XJ@28890|Euryarchaeota,3F2QT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	dUTPase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
DYD2_k127_1264472_0	525904.Tter_1414	4.233e-20	100.0	COG2802@1|root,COG2802@2|Bacteria,2NPRK@2323|unclassified Bacteria	2|Bacteria	S	ATP-dependent protease La (LON) substrate-binding domain	lonD	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
DYD2_k127_1264472_1	1144275.COCOR_02913	1.199e-12	80.0	COG5276@1|root,COG5276@2|Bacteria,1R5D5@1224|Proteobacteria	1224|Proteobacteria	O	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,LVIVD,P_proprotein
DYD2_k127_1264472_2	1144275.COCOR_07947	2.581e-11	76.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_1280058_7	931277.C448_04789	1.326e-26	124.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23TJ1@183963|Halobacteria	183963|Halobacteria	I	COG3425 3-hydroxy-3-methylglutaryl CoA synthase	acaA	-	2.3.3.10	ko:K01641,ko:K07068	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
DYD2_k127_1280058_1	1121430.JMLG01000002_gene1078	1.259e-120	399.0	COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24FFI@186801|Clostridia	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_1280058_5	595536.ADVE02000001_gene818	9.723e-40	163.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21,Methyltransf_25,Methyltransf_31,rRNA_methylase
DYD2_k127_1280058_4	190486.XAC0672	8.253e-49	186.0	COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,1S9D7@1236|Gammaproteobacteria,1X46I@135614|Xanthomonadales	135614|Xanthomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
DYD2_k127_1280058_10	240015.ACP_2256	0.0004568	49.0	2DIW1@1|root,32UBV@2|Bacteria,3Y5BC@57723|Acidobacteria,2JJSS@204432|Acidobacteriia	204432|Acidobacteriia	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
DYD2_k127_1280058_2	70601.3257651	1.345e-75	281.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,243FU@183968|Thermococci	183968|Thermococci	S	TatD related DNase	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
DYD2_k127_1280058_6	1118054.CAGW01000032_gene713	8.773e-34	147.0	COG3011@1|root,COG3011@2|Bacteria,1V7DJ@1239|Firmicutes,4HIUD@91061|Bacilli,26YKY@186822|Paenibacillaceae	91061|Bacilli	S	Thiol-disulfide oxidoreductase DCC	yuxK	-	-	-	-	-	-	-	-	-	-	-	DUF393
DYD2_k127_1280058_11	1288484.APCS01000025_gene2452	0.0006313	48.0	2CA4F@1|root,33DCB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1280058_3	224325.AF_0509	1.831e-52	196.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,245QR@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
DYD2_k127_1280058_0	1118054.CAGW01000043_gene1101	1.556e-135	441.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HAKV@91061|Bacilli,274FZ@186822|Paenibacillaceae	91061|Bacilli	I	Acyl-CoA dehydrogenase, middle domain	acdA	-	1.3.8.1,1.3.8.7	ko:K00248,ko:K00249	ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_1280058_9	797210.Halxa_1439	5.395e-05	55.0	COG0681@1|root,arCOG01739@2157|Archaea,2XU45@28890|Euryarchaeota,23U0G@183963|Halobacteria	183963|Halobacteria	U	COG0681 Signal peptidase I	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DYD2_k127_1280058_8	268739.Nmlp_1101	9.356e-09	63.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
DYD2_k127_1309272_13	673860.AciM339_1279	3.547e-12	78.0	arCOG05352@1|root,arCOG05352@2157|Archaea,2Y75N@28890|Euryarchaeota,3F3FP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1309272_7	673860.AciM339_1278	4.82e-34	147.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,3F2RP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5
DYD2_k127_1309272_6	69014.TK0927	3.787e-40	159.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,242SP@183968|Thermococci	183968|Thermococci	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
DYD2_k127_1309272_11	69014.TK1618	5.178e-14	82.0	COG0622@1|root,arCOG01141@2157|Archaea,2XX8V@28890|Euryarchaeota,2430D@183968|Thermococci	183968|Thermococci	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
DYD2_k127_1309272_12	2903.EOD39971	2.995e-13	73.0	COG0457@1|root,KOG0548@2759|Eukaryota	2759|Eukaryota	J	positive regulation of catalytic activity in other organism involved in symbiotic interaction	TTC28	GO:0000922,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005813,GO:0005815,GO:0005819,GO:0005856,GO:0007346,GO:0008150,GO:0015630,GO:0019899,GO:0019900,GO:0030496,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051233,GO:0051726,GO:0065007,GO:0072686,GO:0097431,GO:1990023	-	ko:K14861	-	-	-	-	ko00000,ko03009	-	-	-	CHAT,TPR_12,TPR_16,TPR_7,TPR_8
DYD2_k127_1309272_20	882083.SacmaDRAFT_4919	0.0006113	50.0	COG1846@1|root,COG1846@2|Bacteria,2GRCT@201174|Actinobacteria,4E6VZ@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
DYD2_k127_1309272_10	268739.Nmlp_1938	1.154e-16	92.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,23UR0@183963|Halobacteria	183963|Halobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24
DYD2_k127_1309272_16	1128421.JAGA01000002_gene1633	8.477e-09	64.0	arCOG08811@1|root,32UTS@2|Bacteria,2NR80@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1309272_9	28444.JODQ01000006_gene820	1.379e-24	119.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4EKXV@85012|Streptosporangiales	201174|Actinobacteria	P	CopC domain	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD
DYD2_k127_1309272_17	270374.MELB17_00490	2.753e-08	62.0	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
DYD2_k127_1309272_5	1396418.BATQ01000113_gene4631	1.286e-42	178.0	COG1723@1|root,COG1723@2|Bacteria	2|Bacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	yagE	-	-	-	-	-	-	-	-	-	-	-	DUF155
DYD2_k127_1309272_1	485915.Dret_1480	1.904e-93	326.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2M7YC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase domain protein	rhlE-2	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
DYD2_k127_1309272_4	555088.DealDRAFT_2172	3.225e-51	208.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC3@186801|Clostridia,42JJ8@68298|Syntrophomonadaceae	186801|Clostridia	H	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
DYD2_k127_1309272_3	264732.Moth_2108	8.574e-93	324.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,42FM5@68295|Thermoanaerobacterales	186801|Clostridia	EH	Anthranilate synthase component I, N terminal region	pabB	-	2.6.1.85,4.1.3.27	ko:K01657,ko:K01665,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
DYD2_k127_1309272_14	1045009.AFXQ01000007_gene2949	3.206e-11	72.0	COG1522@1|root,COG1522@2|Bacteria,2GMSR@201174|Actinobacteria,1W9BD@1268|Micrococcaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
DYD2_k127_1309272_0	1254432.SCE1572_44330	7.221e-103	349.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,42T5F@68525|delta/epsilon subdivisions,2WQVP@28221|Deltaproteobacteria,2YU42@29|Myxococcales	28221|Deltaproteobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.3.46	ko:K16422	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06633	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
DYD2_k127_1309272_8	47763.JNZA01000004_gene3694	3.52e-27	125.0	COG0477@1|root,COG2814@2|Bacteria,2GJU2@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
DYD2_k127_1309272_15	1346330.M472_21740	4.262e-11	71.0	COG2849@1|root,COG2849@2|Bacteria,4NMDX@976|Bacteroidetes,1IUCU@117747|Sphingobacteriia	976|Bacteroidetes	S	MORN repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2,TPR_1,TPR_16,TPR_2,TPR_8
DYD2_k127_1309272_18	246197.MXAN_3826	2.578e-07	60.0	COG0551@1|root,COG0551@2|Bacteria,1NU8S@1224|Proteobacteria	1224|Proteobacteria	L	Protein of unknown function (DUF1587)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt3,PSD2,PSD3,PSD4,PSD5
DYD2_k127_1309272_19	153721.MYP_525	1.307e-06	54.0	COG2304@1|root,COG2304@2|Bacteria,4NDUC@976|Bacteroidetes,47JUP@768503|Cytophagia	976|Bacteroidetes	S	PFAM von Willebrand factor type A	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
DYD2_k127_1327863_1	351160.RRC525	2.558e-73	270.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
DYD2_k127_1327863_2	479435.Kfla_6958	1.161e-53	202.0	COG0382@1|root,COG0382@2|Bacteria,2IJV5@201174|Actinobacteria	201174|Actinobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
DYD2_k127_1327863_4	693661.Arcve_0149	1.341e-18	94.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_1327863_6	1041930.Mtc_0976	2.654e-14	84.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,2N9ZM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_1327863_0	469382.Hbor_06050	4.533e-100	352.0	arCOG10180@1|root,arCOG10180@2157|Archaea,2XUY5@28890|Euryarchaeota,23U72@183963|Halobacteria	183963|Halobacteria	S	membrane-bound metal-dependent	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
DYD2_k127_1327863_7	68219.JNXI01000032_gene7052	6.989e-13	82.0	COG3794@1|root,COG3794@2|Bacteria,2GS7W@201174|Actinobacteria	201174|Actinobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
DYD2_k127_1327863_5	864069.MicloDRAFT_00051780	3.15e-18	99.0	COG3568@1|root,COG3568@2|Bacteria,1R977@1224|Proteobacteria,2U1NE@28211|Alphaproteobacteria,1JSZH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
DYD2_k127_1327863_3	1236689.MMALV_03850	7.623e-38	149.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,3F2SI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
DYD2_k127_1345615_7	518766.Rmar_0580	9.436e-30	128.0	COG0406@1|root,COG0406@2|Bacteria,4NFX5@976|Bacteroidetes,1FJ9S@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglycerate mutase family	gpm	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
DYD2_k127_1345615_2	1173028.ANKO01000174_gene2700	4.41e-109	372.0	COG4325@1|root,COG4325@2|Bacteria,1G2Y0@1117|Cyanobacteria,1H8XM@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
DYD2_k127_1345615_6	391735.Veis_0127	2.334e-30	126.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,2VRSQ@28216|Betaproteobacteria,4ADXN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
DYD2_k127_1345615_0	647113.Metok_0524	5.328e-289	914.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
DYD2_k127_1345615_1	693661.Arcve_1710	2.613e-113	389.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,245U4@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos
DYD2_k127_1345615_4	272569.rrnAC1776	6.214e-73	251.0	COG0717@1|root,arCOG04048@2157|Archaea,2XTSH@28890|Euryarchaeota,23S4X@183963|Halobacteria	183963|Halobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
DYD2_k127_1345615_8	208444.JNYY01000009_gene3587	2.596e-20	106.0	COG4409@1|root,COG4409@2|Bacteria,2IDDY@201174|Actinobacteria	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1345615_9	1226325.HMPREF1548_06681	7.292e-06	60.0	COG4640@1|root,COG4640@2|Bacteria,1V6VZ@1239|Firmicutes,24MGT@186801|Clostridia	186801|Clostridia	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zinc_ribbon_2
DYD2_k127_1345615_5	1267005.KB911260_gene3529	2.038e-55	214.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2TVQV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
DYD2_k127_1345615_3	867903.ThesuDRAFT_00075	8.166e-103	349.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,3WCHT@538999|Clostridiales incertae sedis	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
DYD2_k127_1386959_2	1356852.N008_14525	9.189e-07	52.0	28PB4@1|root,2ZC42@2|Bacteria,4NJ4V@976|Bacteroidetes,47QQM@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1386959_0	999630.TUZN_0880	6.464e-44	166.0	COG1881@1|root,arCOG04702@2157|Archaea,2XQN7@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
DYD2_k127_1388497_7	1172188.KB911824_gene3399	3.822e-39	166.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1388497_1	662479.C440_01470	4.076e-93	320.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUT0@28890|Euryarchaeota,23TBY@183963|Halobacteria	183963|Halobacteria	E	ABC-type multidrug transport system, ATPase component	trp5	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DYD2_k127_1388497_0	406552.NJ7G_3261	1.79e-106	367.0	COG1668@1|root,arCOG04450@2157|Archaea,2XTRJ@28890|Euryarchaeota,23TJ2@183963|Halobacteria	183963|Halobacteria	C	COG1668 ABC-type Na efflux pump, permease component	natB2	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,PrsW-protease
DYD2_k127_1388497_6	523841.HFX_1506	1.722e-41	178.0	COG1668@1|root,arCOG01470@2157|Archaea,2XU06@28890|Euryarchaeota,23T4E@183963|Halobacteria	183963|Halobacteria	C	COG1668 ABC-type Na efflux pump, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
DYD2_k127_1388497_9	1163407.UU7_04432	8.248e-33	142.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X5U0@135614|Xanthomonadales	135614|Xanthomonadales	T	c-di-gmp phosphodiesterase	pdeA	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,PAS_9
DYD2_k127_1388497_3	1489678.RDMS_12985	4.755e-79	275.0	COG1230@1|root,COG1230@2|Bacteria	2|Bacteria	P	cation diffusion facilitator family transporter	zitB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	iNRG857_1313.NRG857_03325,iPC815.YPO1129	Cation_efflux,ZT_dimer
DYD2_k127_1388497_2	1341151.ASZU01000010_gene1848	1.058e-86	298.0	COG3424@1|root,COG3424@2|Bacteria,1TPUK@1239|Firmicutes,4HBHH@91061|Bacilli,27B3Q@186824|Thermoactinomycetaceae	91061|Bacilli	Q	Chalcone and stilbene synthases, N-terminal domain	bcsA	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
DYD2_k127_1388497_8	67281.JNZZ01000019_gene123	1.248e-34	151.0	COG1755@1|root,COG1755@2|Bacteria,2IG52@201174|Actinobacteria,41AR5@629295|Streptomyces griseus group	201174|Actinobacteria	S	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	srsB	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
DYD2_k127_1388497_10	673860.AciM339_1207	3.889e-14	81.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75G@28890|Euryarchaeota,3F3FD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
DYD2_k127_1388497_4	272844.PAB0722	1.083e-66	257.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2431W@183968|Thermococci	183968|Thermococci	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
DYD2_k127_1388497_5	1033806.HTIA_1861	4.653e-43	177.0	COG0639@1|root,arCOG01143@2157|Archaea,2XUDG@28890|Euryarchaeota,23TZJ@183963|Halobacteria	183963|Halobacteria	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	rad24	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
DYD2_k127_1399604_0	1054217.TALC_00553	0.0	1170.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,241KM@183967|Thermoplasmata	183967|Thermoplasmata	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
DYD2_k127_1399604_5	521011.Mpal_0430	1.091e-10	74.0	COG0614@1|root,arCOG02527@1|root,arCOG02527@2157|Archaea,arCOG03611@2157|Archaea,2XZJV@28890|Euryarchaeota,2NA0Y@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1399604_2	330214.NIDE0254	7.279e-94	335.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DYD2_k127_1399604_4	1236689.MMALV_01570	1.41e-78	267.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,3F2J8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
DYD2_k127_1399604_1	1457250.BBMO01000001_gene924	3.432e-101	361.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota,23TPT@183963|Halobacteria	183963|Halobacteria	L	DNA polymerase elongation subunit (Family B)	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
DYD2_k127_1399604_7	797114.C475_19568	2.49e-08	67.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XXYB@28890|Euryarchaeota,23WG9@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1399604_3	290397.Adeh_2342	5.337e-87	303.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,42PNZ@68525|delta/epsilon subdivisions,2WM13@28221|Deltaproteobacteria,2YUDU@29|Myxococcales	28221|Deltaproteobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
DYD2_k127_1399604_6	1449351.RISW2_12265	1.211e-10	68.0	COG0589@1|root,COG0589@2|Bacteria,1RDMJ@1224|Proteobacteria,2U769@28211|Alphaproteobacteria,4KMMH@93682|Roseivivax	28211|Alphaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DYD2_k127_1399604_8	192952.MM_0231	6.066e-06	59.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y6YV@28890|Euryarchaeota,2NAUI@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1417472_9	1227484.C471_06208	5.534e-11	73.0	COG1961@1|root,arCOG03162@2157|Archaea,2XZU1@28890|Euryarchaeota,23Y7Y@183963|Halobacteria	183963|Halobacteria	L	resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
DYD2_k127_1417472_3	765913.ThidrDRAFT_1810	5.383e-49	203.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
DYD2_k127_1417472_0	693661.Arcve_2088	8.908e-142	496.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2462T@183980|Archaeoglobi	183980|Archaeoglobi	K	DEAD H associated domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
DYD2_k127_1417472_7	1457250.BBMO01000003_gene3100	4.746e-17	84.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,23WV5@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
DYD2_k127_1417472_4	386456.JQKN01000001_gene1765	6.778e-44	167.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,23PIV@183925|Methanobacteria	183925|Methanobacteria	Q	Ribosomal protein L11 methyltransferase (PrmA)	prmA	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
DYD2_k127_1417472_6	673860.AciM339_1005	9.209e-23	103.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2Y72T@28890|Euryarchaeota,3F3AH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1417472_8	693661.Arcve_1350	1.66e-16	87.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,246FC@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
DYD2_k127_1417472_5	192952.MM_2268	5.625e-31	126.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2N9SC@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription termination protein NusA	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
DYD2_k127_1417472_1	324602.Caur_2529	5.481e-88	307.0	COG1283@1|root,COG1283@2|Bacteria,2GABF@200795|Chloroflexi,374Y2@32061|Chloroflexia	32061|Chloroflexia	P	Na+/Pi-cotransporter	-	-	-	-	-	-	-	-	-	-	-	-	Na_Pi_cotrans
DYD2_k127_1417472_2	269797.Mbar_A0979	9.091e-83	297.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
DYD2_k127_1417472_10	870187.Thini_1555	4.465e-05	50.0	COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,1RBM1@1224|Proteobacteria	1224|Proteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_1435597_7	485913.Krac_9227	1.473e-48	191.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.9,4.1.1.19	ko:K00943,ko:K01585	ko00240,ko00330,ko01100,map00240,map00330,map01100	M00053,M00133	R00566,R02094,R02098	RC00002,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
DYD2_k127_1435597_2	485913.Krac_9228	4.535e-79	271.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
DYD2_k127_1435597_1	518766.Rmar_1244	5.582e-105	362.0	COG0248@1|root,COG0248@2|Bacteria,4NH03@976|Bacteroidetes,1FIST@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	FP	Ppx/GppA phosphatase family	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
DYD2_k127_1435597_17	324602.Caur_1815	4.091e-15	84.0	2EDP2@1|root,337IR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
DYD2_k127_1435597_0	673860.AciM339_0705	6.732e-109	364.0	COG0714@1|root,arCOG00434@2157|Archaea	2157|Archaea	S	ATPase associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_1435597_6	1168065.DOK_13939	3.236e-58	222.0	COG1344@1|root,COG1409@1|root,COG1344@2|Bacteria,COG1409@2|Bacteria,1NXRI@1224|Proteobacteria,1S1N6@1236|Gammaproteobacteria,1J9SF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Calcineurin-like phosphoesterase	-	-	3.1.3.2	ko:K14379	ko00740,ko01100,ko04142,ko04380,ko05323,map00740,map01100,map04142,map04380,map05323	-	R00548	RC00017	ko00000,ko00001,ko01000	-	-	-	Metallophos
DYD2_k127_1435597_8	1041930.Mtc_1975	8.47e-48	195.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2N9P3@224756|Methanomicrobia	224756|Methanomicrobia	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
DYD2_k127_1435597_4	118173.KB235914_gene1700	6.422e-71	265.0	COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria,1H7JB@1150|Oscillatoriales	1117|Cyanobacteria	P	Phosphate ABC transporter substrate-binding protein, PhoT family	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like,PBP_like_2
DYD2_k127_1435597_16	1033806.HTIA_2141	8.092e-16	91.0	COG1721@1|root,arCOG06437@1|root,arCOG02742@2157|Archaea,arCOG06437@2157|Archaea,2XTP9@28890|Euryarchaeota,23S9J@183963|Halobacteria	183963|Halobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
DYD2_k127_1435597_3	316274.Haur_2819	2.078e-72	281.0	COG3266@1|root,COG3266@2|Bacteria,2G7UN@200795|Chloroflexi,377BD@32061|Chloroflexia	32061|Chloroflexia	K	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1435597_21	1454010.JEOE01000005_gene1696	1.527e-06	64.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_1435597_19	397278.JOJN01000019_gene2333	4.864e-11	79.0	COG2132@1|root,COG2133@1|root,COG2982@1|root,COG3291@1|root,COG3401@1|root,COG4733@1|root,COG2132@2|Bacteria,COG2133@2|Bacteria,COG2982@2|Bacteria,COG3291@2|Bacteria,COG3401@2|Bacteria,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PA14
DYD2_k127_1435597_10	436308.Nmar_0479	1.202e-32	147.0	COG0226@1|root,arCOG00213@2157|Archaea,41SXU@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM phosphate ABC transporter	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
DYD2_k127_1435597_14	1487953.JMKF01000067_gene3885	4.597e-17	91.0	COG2062@1|root,COG2062@2|Bacteria,1G6QD@1117|Cyanobacteria,1HBRK@1150|Oscillatoriales	1117|Cyanobacteria	T	Phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
DYD2_k127_1435597_11	547559.Nmag_2552	2.564e-22	113.0	COG3408@1|root,arCOG03287@2157|Archaea,2XTVQ@28890|Euryarchaeota,23UN3@183963|Halobacteria	183963|Halobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1435597_9	644966.Tmar_1195	9.464e-40	171.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,3WD9P@538999|Clostridiales incertae sedis	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_1435597_13	448385.sce0969	2.599e-17	83.0	COG1409@1|root,COG1409@2|Bacteria,1R0BM@1224|Proteobacteria,43CTY@68525|delta/epsilon subdivisions,2X81I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1435597_18	448385.sce0969	2.005e-12	74.0	COG1409@1|root,COG1409@2|Bacteria,1R0BM@1224|Proteobacteria,43CTY@68525|delta/epsilon subdivisions,2X81I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1435597_12	1004785.AMBLS11_15780	6.147e-20	103.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,465UW@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD,Peptidase_S8
DYD2_k127_1435597_20	1122605.KB893643_gene795	5.807e-11	70.0	COG1913@1|root,COG1913@2|Bacteria,4NJFJ@976|Bacteroidetes	976|Bacteroidetes	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
DYD2_k127_1435597_5	273075.Ta0947	4.087e-70	249.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota	28890|Euryarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_1435597_15	530564.Psta_2436	3.651e-16	78.0	COG1530@1|root,COG1530@2|Bacteria,2IWSS@203682|Planctomycetes	203682|Planctomycetes	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
DYD2_k127_1449927_0	1254432.SCE1572_22865	1.824e-131	442.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1MWRF@1224|Proteobacteria,42T1Q@68525|delta/epsilon subdivisions,2X5JE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHAT,NB-ARC,Pkinase,TIR_2,TPR_12,TPR_16,TPR_2,TPR_4,TPR_7,TPR_8
DYD2_k127_1449927_3	269797.Mbar_A1866	5.293e-54	203.0	COG1712@1|root,arCOG00254@2157|Archaea,2XUNA@28890|Euryarchaeota,2NBJI@224756|Methanomicrobia	224756|Methanomicrobia	F	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
DYD2_k127_1449927_6	29540.C481_20031	9.935e-45	170.0	COG3358@1|root,arCOG04570@2157|Archaea,2XX3J@28890|Euryarchaeota,23VM5@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
DYD2_k127_1449927_7	1054217.TALC_00545	5.084e-42	161.0	COG0131@1|root,arCOG04398@2157|Archaea,2XT2K@28890|Euryarchaeota,242GZ@183967|Thermoplasmata	183967|Thermoplasmata	E	Imidazoleglycerol-phosphate dehydratase	-	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
DYD2_k127_1449927_4	1379270.AUXF01000002_gene1405	6.933e-46	184.0	COG0106@1|root,COG0106@2|Bacteria,1ZSZJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DYD2_k127_1449927_5	69014.TK0246	2.638e-45	186.0	COG0118@1|root,arCOG00089@2157|Archaea,2XTJ7@28890|Euryarchaeota,243V5@183968|Thermococci	183968|Thermococci	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
DYD2_k127_1449927_2	1144275.COCOR_03708	9.385e-61	233.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_1449927_1	877455.Metbo_1367	5.749e-87	297.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,23NVT@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
DYD2_k127_1460310_5	1341151.ASZU01000008_gene1530	1.765e-08	61.0	2DRIA@1|root,33BX1@2|Bacteria,1VY3D@1239|Firmicutes,4HX43@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1460310_6	1121933.AUHH01000003_gene1432	1.008e-05	57.0	COG0454@1|root,COG0456@2|Bacteria,2HZJQ@201174|Actinobacteria,4DRZ3@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DYD2_k127_1460310_1	1120971.AUCA01000049_gene794	1.98e-76	273.0	COG1783@1|root,COG1783@2|Bacteria,1VK0H@1239|Firmicutes,4HQ2H@91061|Bacilli	91061|Bacilli	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
DYD2_k127_1460310_3	1448860.BBJO01000030_gene173	1.036e-25	124.0	28HNA@1|root,2N5ND@2157|Archaea,2XW09@28890|Euryarchaeota,23UMS@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1460310_4	1217715.F994_02778	1.047e-23	110.0	2EPAR@1|root,33GXH@2|Bacteria,1N7YQ@1224|Proteobacteria,1STFM@1236|Gammaproteobacteria,3NJS2@468|Moraxellaceae	1236|Gammaproteobacteria	S	RyR domain	-	-	-	-	-	-	-	-	-	-	-	-	RyR
DYD2_k127_1460310_0	1313301.AUGC01000008_gene475	2.595e-142	474.0	COG0031@1|root,COG0031@2|Bacteria,4NDZ9@976|Bacteroidetes	976|Bacteroidetes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
DYD2_k127_1460310_2	450851.PHZ_c0778	1.304e-38	148.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2TR5R@28211|Alphaproteobacteria,2KG5S@204458|Caulobacterales	204458|Caulobacterales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
DYD2_k127_1475034_3	1343739.PAP_06530	2.174e-17	88.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
DYD2_k127_1475034_1	316274.Haur_3795	1.287e-51	190.0	COG1528@1|root,COG1528@2|Bacteria,2G8JG@200795|Chloroflexi,37728@32061|Chloroflexia	32061|Chloroflexia	C	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
DYD2_k127_1475034_4	1353537.TP2_15885	4.318e-15	86.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2XP6G@285107|Thioclava	28211|Alphaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
DYD2_k127_1475034_0	1121945.ATXS01000019_gene933	1.202e-81	294.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
DYD2_k127_1475034_2	265072.Mfla_1130	6.887e-34	150.0	COG0475@1|root,COG0475@2|Bacteria,1QTSD@1224|Proteobacteria,2WGUK@28216|Betaproteobacteria,2KNNW@206350|Nitrosomonadales	206350|Nitrosomonadales	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
DYD2_k127_1476114_2	351160.RCIX283	1.805e-18	92.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,2N98U@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
DYD2_k127_1476114_3	1094980.Mpsy_1797	4.216e-18	87.0	COG1745@1|root,arCOG02254@2157|Archaea,2XZ09@28890|Euryarchaeota,2NA4W@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0058	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
DYD2_k127_1476114_1	69014.TK2214	7.126e-25	112.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2432R@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
DYD2_k127_1476114_4	351160.RCIX280	2.294e-06	56.0	COG1255@1|root,arCOG04385@2157|Archaea,2XYWU@28890|Euryarchaeota,2NBE6@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0146 family	-	-	-	ko:K09713	-	-	-	-	ko00000	-	-	-	UPF0146
DYD2_k127_1476114_0	693661.Arcve_1074	7.819e-105	359.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,2462F@183980|Archaeoglobi	183980|Archaeoglobi	E	phosphoserine phosphatase SerB	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	ACT_6,HAD
DYD2_k127_1539896_1	368407.Memar_0091	2.172e-15	87.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_1539896_0	158189.SpiBuddy_0153	1.918e-23	110.0	COG2761@1|root,COG2761@2|Bacteria	2|Bacteria	Q	protein disulfide oxidoreductase activity	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_5
DYD2_k127_1553537_5	452637.Oter_1372	9.395e-15	75.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	ysfE	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
DYD2_k127_1553537_7	643648.Slip_0779	7.245e-10	68.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42JZR@68298|Syntrophomonadaceae	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DYD2_k127_1553537_1	316274.Haur_2243	8.51e-158	514.0	COG1271@1|root,COG1271@2|Bacteria,2G63Q@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome bd ubiquinol oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
DYD2_k127_1553537_2	644966.Tmar_0737	2.544e-103	347.0	COG1294@1|root,COG1294@2|Bacteria,1TPYX@1239|Firmicutes,24YZ7@186801|Clostridia	186801|Clostridia	C	Cytochrome bd terminal oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
DYD2_k127_1553537_6	685035.ADAE01000012_gene130	2.778e-10	73.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,2UFZ7@28211|Alphaproteobacteria,2K68T@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
DYD2_k127_1553537_9	1227484.C471_01097	0.0009201	45.0	arCOG08146@1|root,arCOG08146@2157|Archaea,2XZH2@28890|Euryarchaeota,23X8V@183963|Halobacteria	183963|Halobacteria	K	Putative antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
DYD2_k127_1553537_8	1451261.AS96_03215	3.769e-09	67.0	COG1487@1|root,COG1487@2|Bacteria,2IN9Z@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_1553537_0	1408823.AXUS01000037_gene2861	1.33e-181	582.0	COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,249IU@186801|Clostridia,25S39@186804|Peptostreptococcaceae	186801|Clostridia	O	assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
DYD2_k127_1553537_3	1278073.MYSTI_03625	4.793e-88	302.0	COG0665@1|root,COG0665@2|Bacteria,1NCJX@1224|Proteobacteria,431XD@68525|delta/epsilon subdivisions,2WWSZ@28221|Deltaproteobacteria,2YUQQ@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.3.3	ko:K00273	ko00260,ko00311,ko00330,ko00472,ko01100,ko01130,ko04146,map00260,map00311,map00330,map00472,map01100,map01130,map04146	-	R00366,R02457,R02894,R02923,R04221,R07400	RC00006,RC00018,RC00135	ko00000,ko00001,ko01000	-	-	-	DAO
DYD2_k127_1553537_4	439481.Aboo_0606	3.34e-62	218.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,3F2M8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
DYD2_k127_161206_1	410358.Mlab_1483	8.99e-47	174.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,2N9QY@224756|Methanomicrobia	224756|Methanomicrobia	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
DYD2_k127_161206_3	387631.Asulf_00073	1.912e-21	97.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,246BU@183980|Archaeoglobi	183980|Archaeoglobi	L	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
DYD2_k127_161206_4	195522.BD01_0846	2.506e-08	61.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota,244NC@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
DYD2_k127_161206_2	1236689.MMALV_08010	2.14e-24	104.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,3F2SS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the ribosomal protein L31e family	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
DYD2_k127_161206_0	1261545.MBE-HAL_0915	2.12e-57	209.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,23SZE@183963|Halobacteria	183963|Halobacteria	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
DYD2_k127_1631448_4	604354.TSIB_1862	2.271e-29	123.0	COG1720@1|root,arCOG00761@2157|Archaea,2XY3D@28890|Euryarchaeota,2440R@183968|Thermococci	183968|Thermococci	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
DYD2_k127_1631448_1	1094980.Mpsy_2726	5.611e-73	253.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
DYD2_k127_1631448_2	84531.JMTZ01000014_gene2827	1.684e-59	229.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X8D9@135614|Xanthomonadales	135614|Xanthomonadales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_1631448_0	309801.trd_A0395	2.37e-87	312.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi,27XHZ@189775|Thermomicrobia	189775|Thermomicrobia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
DYD2_k127_1631448_3	309801.trd_A0786	4.191e-36	158.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZW@200795|Chloroflexi,27YUJ@189775|Thermomicrobia	189775|Thermomicrobia	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
DYD2_k127_1631448_8	368407.Memar_1770	3.896e-05	54.0	COG1716@1|root,arCOG01694@2157|Archaea,2Y06S@28890|Euryarchaeota	28890|Euryarchaeota	K	FHA domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HTH_5
DYD2_k127_1631448_7	1120958.AULD01000006_gene165	2.254e-13	75.0	2C9IE@1|root,32UBS@2|Bacteria,2INT4@201174|Actinobacteria,4FNU6@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
DYD2_k127_1631448_6	979556.MTES_2246	5.234e-15	81.0	2C9IE@1|root,32UBS@2|Bacteria,2INT4@201174|Actinobacteria,4FNU6@85023|Microbacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
DYD2_k127_1631448_5	292459.STH892	4.216e-15	85.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.13,3.6.1.55,3.6.1.67	ko:K01515,ko:K03574,ko:K08310,ko:K19965	ko00230,ko00790,map00230,map00790	M00126	R01054,R04638	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	NUDIX
DYD2_k127_1754975_4	446469.Sked_04160	1.707e-24	106.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria	201174|Actinobacteria	H	ABC transporter, periplasmic binding protein, thiB subfamily	tbpA	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
DYD2_k127_1754975_2	765420.OSCT_0521	1.732e-95	332.0	COG1178@1|root,COG1178@2|Bacteria,2G63A@200795|Chloroflexi,3762R@32061|Chloroflexia	32061|Chloroflexia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
DYD2_k127_1754975_3	1463858.JOHR01000017_gene4602	5.726e-76	265.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	fbpC	-	-	ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
DYD2_k127_1754975_6	309798.COPRO5265_0509	0.0001958	47.0	COG0209@1|root,COG1645@1|root,COG0209@2|Bacteria,COG1645@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
DYD2_k127_1754975_5	240016.ABIZ01000001_gene866	1.528e-11	75.0	COG0625@1|root,COG0625@2|Bacteria,46SQB@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
DYD2_k127_1754975_1	1403819.BATR01000162_gene5348	3.255e-103	356.0	COG1253@1|root,COG1253@2|Bacteria,46SMD@74201|Verrucomicrobia,2IU23@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
DYD2_k127_1754975_0	439481.Aboo_0538	1.044e-131	432.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,3F2GD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	GTPase of unknown function C-terminal	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
DYD2_k127_1807832_3	1549858.MC45_04025	1.023e-31	145.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,2K1ER@204457|Sphingomonadales	204457|Sphingomonadales	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
DYD2_k127_1807832_1	1121406.JAEX01000012_gene704	7.697e-88	308.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2M7SQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DYD2_k127_1807832_2	357808.RoseRS_2395	7.804e-61	222.0	COG0451@1|root,COG0451@2|Bacteria,2G6ET@200795|Chloroflexi,375HU@32061|Chloroflexia	32061|Chloroflexia	M	short-chain dehydrogenase reductase SDR	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
DYD2_k127_1807832_4	351160.RCIX180	6.502e-07	61.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_1807832_0	351160.RCIX58	5.353e-293	923.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
DYD2_k127_1839053_0	1042877.GQS_01555	6.384e-121	396.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,243N7@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_1839053_1	1042877.GQS_01560	2.704e-34	148.0	COG1721@1|root,arCOG02742@2157|Archaea,2Y66Z@28890|Euryarchaeota,243NR@183968|Thermococci	183968|Thermococci	S	a von Willebrand factor type A (VWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_1842640_2	529709.PYCH_13920	3.893e-23	111.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
DYD2_k127_1842640_3	1463864.JOGO01000120_gene242	1.226e-07	63.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_6,Acetyltransf_7,Acetyltransf_9
DYD2_k127_1842640_0	448385.sce3666	1.979e-111	403.0	COG1028@1|root,COG1028@2|Bacteria,1MVKN@1224|Proteobacteria,433T9@68525|delta/epsilon subdivisions,2X3CY@28221|Deltaproteobacteria,2YTTY@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_1842640_1	570268.ANBB01000013_gene3127	9.133e-47	175.0	COG1309@1|root,COG1309@2|Bacteria,2IDS1@201174|Actinobacteria,4EPXA@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
DYD2_k127_1842640_4	583355.Caka_1937	0.0009943	52.0	COG3291@1|root,COG3591@1|root,COG3291@2|Bacteria,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_35,CBM_6,CHU_C,He_PIG,PKD,Trypsin_2
DYD2_k127_1871151_2	292459.STH2899	6.973e-51	195.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia	186801|Clostridia	E	PHP domain protein	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
DYD2_k127_1871151_0	580332.Slit_2174	1.288e-88	314.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VKNA@28216|Betaproteobacteria	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	aidB_1	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
DYD2_k127_1871151_5	521011.Mpal_1546	9.968e-05	53.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DYD2_k127_1871151_3	571166.KI421509_gene4310	5.254e-11	75.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_1871151_1	1094980.Mpsy_2333	3.468e-61	231.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
DYD2_k127_1885114_2	439481.Aboo_1397	1.342e-52	194.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,3F2KM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
DYD2_k127_1885114_3	351160.RCIX2580	5.938e-42	164.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
DYD2_k127_1885114_0	572546.Arcpr_1629	3.987e-148	486.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
DYD2_k127_1885114_4	304371.MCP_0211	8.598e-28	120.0	COG1321@1|root,arCOG02099@2157|Archaea,2XSWC@28890|Euryarchaeota,2N9TX@224756|Methanomicrobia	224756|Methanomicrobia	K	FeoA	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
DYD2_k127_1885114_1	521674.Plim_3436	9.23e-90	303.0	COG0190@1|root,COG0190@2|Bacteria,2IXS4@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
DYD2_k127_1885114_5	469382.Hbor_26970	5e-20	101.0	COG1326@1|root,arCOG02680@2157|Archaea,2XUFW@28890|Euryarchaeota,23T9W@183963|Halobacteria	183963|Halobacteria	S	archaeal Zn-finger protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1885114_6	999630.TUZN_0971	1.336e-09	62.0	COG0303@1|root,arCOG00217@2157|Archaea,2XPP4@28889|Crenarchaeota	28889|Crenarchaeota	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
DYD2_k127_1890872_1	1206101.AZXC01000021_gene2176	5.96e-38	161.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_1890872_2	573064.Mefer_1348	5.913e-09	68.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVMU@28890|Euryarchaeota,23QEP@183939|Methanococci	183939|Methanococci	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DYD2_k127_1890872_0	572478.Vdis_2025	2.76e-58	211.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
DYD2_k127_1947596_1	351160.LRC378	1.972e-68	259.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota,2NAQG@224756|Methanomicrobia	224756|Methanomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
DYD2_k127_1947596_0	351160.LRC377	5.318e-83	306.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
DYD2_k127_1947596_3	526227.Mesil_0637	3.528e-46	177.0	COG0500@1|root,COG2226@2|Bacteria,1WIUM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
DYD2_k127_1947596_5	319795.Dgeo_1965	1.235e-20	107.0	COG0805@1|root,COG0805@2|Bacteria,1WJCW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
DYD2_k127_1947596_6	926569.ANT_07500	0.0009261	52.0	COG1470@1|root,COG2374@1|root,COG1470@2|Bacteria,COG2374@2|Bacteria,2G82K@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Endonuclease exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_5,Exo_endo_phos,LTD
DYD2_k127_1947596_4	1172188.KB911824_gene3399	7.243e-35	151.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_1947596_2	326427.Cagg_2410	1.287e-56	206.0	COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi,377CS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
DYD2_k127_2035329_1	693661.Arcve_1345	1.29e-106	359.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2461M@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
DYD2_k127_2035329_0	670487.Ocepr_0872	3.666e-148	487.0	COG2986@1|root,COG2986@2|Bacteria,1WISU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Phenylalanine and histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
DYD2_k127_2035329_2	1218076.BAYB01000023_gene4054	6.03e-21	107.0	COG1670@1|root,COG1670@2|Bacteria,1PDMH@1224|Proteobacteria,2VS7P@28216|Betaproteobacteria,1KAEN@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DYD2_k127_2035329_4	679926.Mpet_0192	1.28e-05	56.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_2035329_3	368407.Memar_1756	3.616e-18	95.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24
DYD2_k127_2070842_1	673860.AciM339_1477	2.61e-69	250.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,3F2K5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
DYD2_k127_2070842_2	604354.TSIB_0576	1.829e-07	62.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,244PG@183968|Thermococci	183968|Thermococci	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
DYD2_k127_2070842_0	673860.AciM339_1479	5.309e-89	300.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,3F2GS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
DYD2_k127_2070842_3	1532557.JL37_00585	0.0002033	49.0	COG3177@1|root,COG3177@2|Bacteria,1MXWY@1224|Proteobacteria,2VMBH@28216|Betaproteobacteria,3T4ZB@506|Alcaligenaceae	28216|Betaproteobacteria	K	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
DYD2_k127_2072580_3	481448.Minf_1354	1.427e-43	177.0	COG1039@1|root,COG1039@2|Bacteria,46UTB@74201|Verrucomicrobia,37GU9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
DYD2_k127_2072580_0	1122939.ATUD01000011_gene2256	2.792e-111	368.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4CPFX@84995|Rubrobacteria	84995|Rubrobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_2072580_1	1348663.KCH_18540	7.697e-65	247.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,2M05I@2063|Kitasatospora	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992,ko:K18233	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC2_membrane
DYD2_k127_2072580_2	339860.Msp_0884	3.356e-50	184.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,23NZH@183925|Methanobacteria	183925|Methanobacteria	F	Belongs to the archaeal adenylate kinase family	adkA	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
DYD2_k127_2072580_7	673860.AciM339_1123	1.491e-25	115.0	COG1422@1|root,arCOG02673@2157|Archaea,2XZDK@28890|Euryarchaeota,3F2U5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
DYD2_k127_2072580_4	529709.PYCH_05270	4.043e-42	165.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,242RN@183968|Thermococci	183968|Thermococci	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
DYD2_k127_2072580_8	1449347.JQLN01000005_gene3577	3.956e-13	79.0	COG0745@1|root,COG0745@2|Bacteria,2I2Z1@201174|Actinobacteria,2M320@2063|Kitasatospora	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_2072580_6	309801.trd_0711	1.626e-31	133.0	COG0365@1|root,COG0365@2|Bacteria,2G5KE@200795|Chloroflexi,27XEK@189775|Thermomicrobia	189775|Thermomicrobia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
DYD2_k127_2072580_5	502025.Hoch_0011	5.089e-35	137.0	COG1051@1|root,COG1051@2|Bacteria,1N5QT@1224|Proteobacteria,433SX@68525|delta/epsilon subdivisions,2WXYA@28221|Deltaproteobacteria,2YVMP@29|Myxococcales	28221|Deltaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_2083407_4	1449126.JQKL01000061_gene1911	8.516e-18	89.0	COG0745@1|root,COG0745@2|Bacteria	1449126.JQKL01000061_gene1911|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2083407_0	445335.CBN_1329	5.644e-130	431.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	gapN	-	1.2.1.9	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DYD2_k127_2083407_3	523850.TON_0811	5.947e-18	98.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_2083407_1	511.JT27_13120	1.324e-47	198.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,3T8FK@506|Alcaligenaceae	28216|Betaproteobacteria	F	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,Mrr_cat,SNF2_N
DYD2_k127_2083407_2	192952.MM_1111	1.348e-41	161.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2N9Y8@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
DYD2_k127_2084203_3	1408322.JHYK01000001_gene1571	4.773e-07	57.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,27NNG@186928|unclassified Lachnospiraceae	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DYD2_k127_2084203_2	1123368.AUIS01000001_gene1912	6.607e-77	275.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RMUV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,CHASE5,CHASE8,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
DYD2_k127_2084203_1	439481.Aboo_0781	3.845e-88	299.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,3F2JX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
DYD2_k127_2084203_0	649638.Trad_1831	8.47e-91	306.0	COG2081@1|root,COG2081@2|Bacteria	2|Bacteria	N	HI0933 family	yhiN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DYD2_k127_2089100_16	869210.Marky_0886	2.541e-51	193.0	COG1409@1|root,COG1409@2|Bacteria,1WKV1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
DYD2_k127_2089100_34	335541.Swol_2124	0.0001757	54.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,2481K@186801|Clostridia,42JT5@68298|Syntrophomonadaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
DYD2_k127_2089100_15	670487.Ocepr_0187	1.836e-56	215.0	COG4948@1|root,COG4948@2|Bacteria,1WMNA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Mandelate racemase muconate lactonizing enzyme	ykfB	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
DYD2_k127_2089100_13	266117.Rxyl_2779	4.466e-66	239.0	COG3367@1|root,COG3367@2|Bacteria,2IBUZ@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
DYD2_k127_2089100_1	861299.J421_0859	1.047e-113	400.0	COG0346@1|root,COG0346@2|Bacteria,1ZTUT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
DYD2_k127_2089100_17	1122223.KB890699_gene592	8.289e-51	203.0	COG0400@1|root,COG0400@2|Bacteria,1WK7F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
DYD2_k127_2089100_26	523841.HFX_1666	2.393e-17	96.0	COG5485@1|root,arCOG06513@2157|Archaea,2XYRZ@28890|Euryarchaeota,23WU7@183963|Halobacteria	183963|Halobacteria	S	ester cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
DYD2_k127_2089100_30	1499967.BAYZ01000119_gene3228	1.963e-08	66.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DYD2_k127_2089100_0	324602.Caur_3339	3.317e-124	419.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia	32061|Chloroflexia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
DYD2_k127_2089100_3	1333523.L593_04990	7.229e-100	359.0	COG1287@1|root,arCOG02043@2157|Archaea,2XU8G@28890|Euryarchaeota,23SCX@183963|Halobacteria	183963|Halobacteria	S	membrane protein, required for N-linked glycosylation	aglB	GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0016740,GO:0016757,GO:0045229,GO:0045232,GO:0071840	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
DYD2_k127_2089100_28	1227495.C487_15910	9.225e-14	79.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,23V9I@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
DYD2_k127_2089100_21	266117.Rxyl_2930	2.457e-37	160.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_2089100_6	443255.SCLAV_5668	4.081e-92	320.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
DYD2_k127_2089100_32	406552.NJ7G_3736	7.819e-08	61.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,23UR0@183963|Halobacteria	183963|Halobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24
DYD2_k127_2089100_14	1054217.TALC_00307	4.666e-60	232.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,241SA@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
DYD2_k127_2089100_7	529709.PYCH_07580	2.52e-86	316.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,242MF@183968|Thermococci	183968|Thermococci	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
DYD2_k127_2089100_23	1136417.AZWE01000025_gene771	3.3e-34	145.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4DAHQ@85008|Micromonosporales	201174|Actinobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
DYD2_k127_2089100_12	84531.JMTZ01000014_gene2827	5.199e-73	268.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X8D9@135614|Xanthomonadales	135614|Xanthomonadales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_2089100_20	1236689.MMALV_08080	2.829e-38	152.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,3F2SU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
DYD2_k127_2089100_10	673860.AciM339_1060	1.165e-76	271.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,3F2WK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
DYD2_k127_2089100_8	1094980.Mpsy_2104	2.67e-80	285.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
DYD2_k127_2089100_29	273075.Ta1331	1.875e-12	70.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota,24232@183967|Thermoplasmata	183967|Thermoplasmata	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
DYD2_k127_2089100_4	673860.AciM339_1145	2.954e-92	334.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota,3F364@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	CoA binding domain	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
DYD2_k127_2089100_2	673860.AciM339_1144	4.407e-101	345.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,3F389@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	ATP-grasp domain	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
DYD2_k127_2089100_9	868131.MSWAN_2284	6.929e-78	275.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23NUP@183925|Methanobacteria	183925|Methanobacteria	J	Diphthamide	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
DYD2_k127_2089100_33	1173263.Syn7502_01435	1.019e-05	53.0	COG2002@1|root,COG2002@2|Bacteria,1GARU@1117|Cyanobacteria	1117|Cyanobacteria	K	TIGRFAM looped-hinge helix DNA binding domain, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
DYD2_k127_2089100_24	333138.LQ50_09605	5.986e-21	99.0	COG2337@1|root,COG2337@2|Bacteria,1V6CM@1239|Firmicutes,4HXXC@91061|Bacilli,1ZJRQ@1386|Bacillus	91061|Bacilli	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PemK_toxin
DYD2_k127_2089100_19	1121272.KB903253_gene6807	6.197e-45	178.0	COG0846@1|root,COG0846@2|Bacteria	2|Bacteria	K	NAD+ binding	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
DYD2_k127_2089100_18	573063.Metin_1083	4.039e-50	207.0	COG0503@1|root,arCOG00030@2157|Archaea,2XTWM@28890|Euryarchaeota,23Q0J@183939|Methanococci	183939|Methanococci	F	Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis	hpt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
DYD2_k127_2089100_5	1220534.B655_0046	3.683e-92	317.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,23PE2@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis	mfnA	-	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
DYD2_k127_2089100_11	693661.Arcve_0237	5.156e-76	267.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,246GU@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DYD2_k127_2089100_27	405948.SACE_2457	2.534e-15	89.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4E2RP@85010|Pseudonocardiales	201174|Actinobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DYD2_k127_2089100_22	365046.Rta_09290	1.237e-35	152.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,4AAH8@80864|Comamonadaceae	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
DYD2_k127_2089100_31	671143.DAMO_1233	6.09e-08	64.0	COG4083@1|root,COG4083@2|Bacteria	2|Bacteria	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	groEL	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
DYD2_k127_2104761_1	573064.Mefer_0041	1.502e-51	188.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,23QQ2@183939|Methanococci	183939|Methanococci	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	GO:0003674,GO:0003824,GO:0003861,GO:0016829,GO:0016835,GO:0016836	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
DYD2_k127_2104761_2	1395513.P343_05645	4.447e-07	61.0	COG1695@1|root,COG1695@2|Bacteria,1VAGB@1239|Firmicutes,4HKBS@91061|Bacilli	91061|Bacilli	K	transcriptional	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DYD2_k127_2104761_0	1041930.Mtc_0523	9.352e-92	319.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,2N9BR@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
DYD2_k127_2115976_4	1293048.CBMB010000003_gene888	4.189e-101	336.0	COG0183@1|root,arCOG01282@2157|Archaea,2XU9B@28890|Euryarchaeota,23TGK@183963|Halobacteria	183963|Halobacteria	I	Acetyl-CoA acetyltransferase	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_2115976_5	1123226.KB899301_gene2825	3.108e-79	280.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,26QNA@186822|Paenibacillaceae	91061|Bacilli	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
DYD2_k127_2115976_1	1227487.C474_12296	1.809e-129	424.0	COG1171@1|root,arCOG01431@2157|Archaea,2XT4W@28890|Euryarchaeota,23SNZ@183963|Halobacteria	183963|Halobacteria	E	Threonine dehydratase	ilvA1	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
DYD2_k127_2115976_6	268739.Nmlp_1060	6.467e-76	276.0	COG1701@1|root,arCOG04262@2157|Archaea,2XTAP@28890|Euryarchaeota,23TRA@183963|Halobacteria	183963|Halobacteria	S	protein conserved in archaea	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
DYD2_k127_2115976_2	693661.Arcve_0786	3.084e-121	404.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
DYD2_k127_2115976_0	192952.MM_0087	1.715e-161	524.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,2N9C6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,Molydop_binding,PYNP_C
DYD2_k127_2115976_7	1094980.Mpsy_0792	1.055e-50	196.0	COG3174@1|root,arCOG04203@2157|Archaea,2XT0W@28890|Euryarchaeota,2N9ST@224756|Methanomicrobia	224756|Methanomicrobia	P	MgtC family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
DYD2_k127_2115976_8	304371.MCP_1526	7.448e-20	105.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_2115976_3	186497.PF0418	3.119e-118	393.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,243N7@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_2150197_0	1048834.TC41_1412	1.46e-71	260.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,4HAB3@91061|Bacilli,278YI@186823|Alicyclobacillaceae	91061|Bacilli	L	Belongs to the DEAD box helicase family	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DYD2_k127_2150197_1	644966.Tmar_1357	3.318e-66	238.0	COG2041@1|root,COG2041@2|Bacteria,1UMMR@1239|Firmicutes,24QVC@186801|Clostridia	186801|Clostridia	S	PFAM Oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
DYD2_k127_2150197_2	1227352.C173_18646	3.287e-06	59.0	COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,4HAR9@91061|Bacilli,26SK7@186822|Paenibacillaceae	91061|Bacilli	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
DYD2_k127_2152575_4	1254432.SCE1572_48225	2.616e-208	670.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,43C6M@68525|delta/epsilon subdivisions,2X84I@28221|Deltaproteobacteria,2Z3KT@29|Myxococcales	28221|Deltaproteobacteria	Q	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
DYD2_k127_2152575_9	1242864.D187_006829	3.231e-147	516.0	COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria,43C6Z@68525|delta/epsilon subdivisions	1224|Proteobacteria	IQ	nonribosomal peptide	-	-	-	ko:K18660	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C,Condensation,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
DYD2_k127_2152575_1	1192034.CAP_5339	1.738e-285	929.0	COG1020@1|root,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,TauD,Thioesterase,ketoacyl-synt
DYD2_k127_2152575_0	697282.Mettu_3699	0.0	2911.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1XESZ@135618|Methylococcales	135618|Methylococcales	Q	TIGRFAM Amino acid adenylation	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
DYD2_k127_2152575_3	1144275.COCOR_01685	3.119e-222	708.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,43C63@68525|delta/epsilon subdivisions,2WTQK@28221|Deltaproteobacteria,2YXI2@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter transmembrane region	msbA9	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DYD2_k127_2152575_15	926549.KI421517_gene3273	1.796e-56	204.0	COG4221@1|root,COG4221@2|Bacteria,4NP0J@976|Bacteroidetes,47URZ@768503|Cytophagia	976|Bacteroidetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_2152575_8	595537.Varpa_3054	3.092e-156	500.0	COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,2WEEB@28216|Betaproteobacteria,4ADS9@80864|Comamonadaceae	28216|Betaproteobacteria	M	NmrA-like family	wbiB	-	5.1.3.25	ko:K17947	ko00523,ko01130,map00523,map01130	-	R10279	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
DYD2_k127_2152575_2	926549.KI421517_gene3275	2.428e-263	843.0	COG0451@1|root,COG0451@2|Bacteria,4NDX8@976|Bacteroidetes,47NBZ@768503|Cytophagia	976|Bacteroidetes	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
DYD2_k127_2152575_10	483219.LILAB_00545	1.314e-116	385.0	COG1063@1|root,COG1063@2|Bacteria,1MUK8@1224|Proteobacteria,42W1B@68525|delta/epsilon subdivisions,2WREN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
DYD2_k127_2152575_11	1509405.GV67_02970	1.321e-114	392.0	COG0673@1|root,COG0673@2|Bacteria,1NKUI@1224|Proteobacteria,2TUGN@28211|Alphaproteobacteria,4BAFC@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DYD2_k127_2152575_12	1254432.SCE1572_39735	3.919e-108	376.0	COG0438@1|root,COG0438@2|Bacteria,1Q3IF@1224|Proteobacteria,43794@68525|delta/epsilon subdivisions,2WTY0@28221|Deltaproteobacteria,2YWM7@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_2152575_7	365046.Rta_15990	1.665e-156	520.0	COG4641@1|root,COG4641@2|Bacteria,1MY6E@1224|Proteobacteria,2VZFN@28216|Betaproteobacteria,4AH8Y@80864|Comamonadaceae	28216|Betaproteobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
DYD2_k127_2152575_5	1123368.AUIS01000005_gene424	3.965e-163	539.0	COG4641@1|root,COG4641@2|Bacteria,1MXSZ@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
DYD2_k127_2152575_6	1123368.AUIS01000005_gene446	3.077e-157	515.0	COG4641@1|root,COG4641@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	ykvP	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2
DYD2_k127_2152575_13	1237149.C900_05407	1.411e-102	345.0	COG2227@1|root,COG2227@2|Bacteria,4NZ87@976|Bacteroidetes	976|Bacteroidetes	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,Methyltransf_9
DYD2_k127_2152575_14	368407.Memar_0207	9.03e-77	267.0	COG1004@1|root,arCOG00253@2157|Archaea,2XTQY@28890|Euryarchaeota,2N99M@224756|Methanomicrobia	224756|Methanomicrobia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1119,iAF692.Mbar_A1120	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DYD2_k127_2205431_3	309807.SRU_2769	9.792e-43	164.0	COG2128@1|root,COG2128@2|Bacteria,4NN22@976|Bacteroidetes,1FK4T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	PA26 p53-induced protein (sestrin)	-	-	-	-	-	-	-	-	-	-	-	-	CMD
DYD2_k127_2205431_2	1123261.AXDW01000002_gene1666	5.254e-82	287.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1X5GT@135614|Xanthomonadales	135614|Xanthomonadales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
DYD2_k127_2205431_4	1379698.RBG1_1C00001G0988	6e-14	85.0	COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria	2|Bacteria	C	lyase activity	-	-	3.4.24.3	ko:K01387,ko:K03301	-	-	-	-	ko00000,ko01000,ko01002,ko02042	2.A.12	-	-	DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase
DYD2_k127_2205431_0	869210.Marky_1418	5.88e-164	528.0	COG0114@1|root,COG0114@2|Bacteria,1WJ9Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
DYD2_k127_2205431_5	1448860.BBJO01000074_gene1887	1.96e-05	58.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,23W4I@183963|Halobacteria	183963|Halobacteria	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DYD2_k127_2205431_1	1122917.KB899671_gene4401	3.162e-109	365.0	COG3387@1|root,COG3387@2|Bacteria,1VU0N@1239|Firmicutes,4HVAB@91061|Bacilli,26SWA@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
DYD2_k127_2215985_0	1128421.JAGA01000003_gene3228	9.786e-95	324.0	COG0604@1|root,COG0604@2|Bacteria,2NP5I@2323|unclassified Bacteria	2|Bacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
DYD2_k127_2215985_1	886293.Sinac_2841	2.082e-52	203.0	COG3208@1|root,COG3208@2|Bacteria,2J3X9@203682|Planctomycetes	203682|Planctomycetes	Q	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioesterase
DYD2_k127_2215985_2	1137269.AZWL01000001_gene5660	8.555e-23	107.0	COG2091@1|root,COG2091@2|Bacteria,2IQ65@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the P-Pant transferase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ACPS
DYD2_k127_2249387_4	1463934.JOCF01000035_gene2420	1.267e-07	64.0	COG4409@1|root,COG4409@2|Bacteria,2ID1A@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2249387_3	439481.Aboo_0937	1.026e-33	139.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,3F2R1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	AAA domain	coaE	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0975	AAA_17,RNA_binding
DYD2_k127_2249387_5	1451189.CFAL_11570	1.435e-06	54.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,22N9P@1653|Corynebacteriaceae	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
DYD2_k127_2249387_1	1449976.KALB_1833	2.139e-63	241.0	COG2808@1|root,COG2808@2|Bacteria,2I9QJ@201174|Actinobacteria,4E2N2@85010|Pseudonocardiales	201174|Actinobacteria	K	Putative FMN-binding domain	paiB	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
DYD2_k127_2249387_7	1122604.JONR01000011_gene3599	0.0004016	49.0	2DWEZ@1|root,33ZZS@2|Bacteria,1NYBC@1224|Proteobacteria,1SQSQ@1236|Gammaproteobacteria,1XAUU@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2249387_2	368407.Memar_1121	8.342e-53	192.0	arCOG03570@1|root,arCOG03570@2157|Archaea,2XXVH@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
DYD2_k127_2249387_0	1236689.MMALV_16390	7.624e-84	294.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
DYD2_k127_2263187_4	188626.HMPREF0321_1033	1.894e-16	81.0	COG2761@1|root,COG2761@2|Bacteria,2GNBC@201174|Actinobacteria	201174|Actinobacteria	Q	Dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
DYD2_k127_2263187_0	1121439.dsat_2063	3.826e-121	411.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2M845@213115|Desulfovibrionales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
DYD2_k127_2263187_1	342949.PNA2_1348	5.874e-69	263.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
DYD2_k127_2263187_3	192952.MM_3074	9.239e-45	185.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
DYD2_k127_2263187_5	572478.Vdis_0010	1.719e-09	63.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	HTH_45
DYD2_k127_2263187_2	604354.TSIB_1665	1.238e-65	240.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,243G1@183968|Thermococci	183968|Thermococci	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
DYD2_k127_2264233_0	330214.NIDE2777	7.958e-51	191.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	yddE	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
DYD2_k127_2264233_1	1348114.OM33_08045	1.378e-18	94.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,1RNJC@1236|Gammaproteobacteria,2Q2II@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.96	ko:K17623	-	-	R11180	RC00017	ko00000,ko01000,ko01009	-	-	-	HAD_2
DYD2_k127_2284705_0	869210.Marky_0879	6.574e-65	231.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_2284705_3	1197130.BAFM01000010_gene1848	6.706e-25	115.0	COG2820@1|root,arCOG01324@2157|Archaea,2Y06F@28890|Euryarchaeota,23W2X@183963|Halobacteria	183963|Halobacteria	F	Uridine phosphorylase	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
DYD2_k127_2284705_4	42256.RradSPS_1030	2.374e-13	83.0	COG1306@1|root,COG1306@2|Bacteria,2GNVR@201174|Actinobacteria	201174|Actinobacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
DYD2_k127_2284705_1	1236689.MMALV_02290	2.085e-60	225.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,3F2QB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	snoRNA binding domain, fibrillarin	nop5	GO:0000154,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030515,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
DYD2_k127_2284705_2	523850.TON_1300	1.597e-56	207.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,24333@183968|Thermococci	183968|Thermococci	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
DYD2_k127_2293690_2	1261545.MBE-HAL_2273	7.313e-39	160.0	COG0438@1|root,arCOG01409@2157|Archaea,2Y0YJ@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
DYD2_k127_2293690_1	387631.Asulf_00033	3.612e-44	183.0	COG0438@1|root,arCOG01407@2157|Archaea	2157|Archaea	M	COG0438 Glycosyltransferase	gth2	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
DYD2_k127_2293690_3	387631.Asulf_00034	1.074e-16	93.0	COG0125@1|root,arCOG01891@2157|Archaea,2Y11Y@28890|Euryarchaeota	28890|Euryarchaeota	F	Thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
DYD2_k127_2293690_0	748224.HMPREF9436_00269	2.208e-70	258.0	COG3379@1|root,COG3379@2|Bacteria,1VHYF@1239|Firmicutes,24VS8@186801|Clostridia	186801|Clostridia	Q	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
DYD2_k127_2326728_0	632292.Calhy_1196	4.067e-130	422.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,42EWA@68295|Thermoanaerobacterales	186801|Clostridia	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
DYD2_k127_2326728_1	595537.Varpa_3837	1.611e-71	246.0	COG0346@1|root,COG0346@2|Bacteria,1RABI@1224|Proteobacteria,2VVN9@28216|Betaproteobacteria,4AI4B@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
DYD2_k127_2326728_2	1121920.AUAU01000009_gene1911	9.934e-58	224.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	MFS_1
DYD2_k127_2326728_5	56107.Cylst_0284	1.089e-07	62.0	COG4828@1|root,COG4828@2|Bacteria,1G5WZ@1117|Cyanobacteria,1HQ87@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
DYD2_k127_2326728_3	58123.JOFJ01000001_gene3314	8.971e-54	204.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,4EI6R@85012|Streptosporangiales	201174|Actinobacteria	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
DYD2_k127_2326728_4	268739.Nmlp_2621	4.279e-23	103.0	COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota,23SAC@183963|Halobacteria	183963|Halobacteria	E	COG1121 ABC-type Mn Zn transport systems, ATPase component	znuC2	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
DYD2_k127_233979_1	1041930.Mtc_0887	6.491e-36	141.0	arCOG14251@1|root,arCOG14251@2157|Archaea	2157|Archaea	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
DYD2_k127_233979_0	635013.TherJR_1439	8.211e-121	416.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,2600W@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DYD2_k127_233979_2	1122138.AQUZ01000074_gene7315	1.529e-08	67.0	COG0346@1|root,COG0346@2|Bacteria,2ISP0@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
DYD2_k127_2358836_21	330214.NIDE0807	2.819e-48	190.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,CHASE,EAL,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
DYD2_k127_2358836_8	477974.Daud_1089	1.001e-92	332.0	COG1060@1|root,COG1060@2|Bacteria,1TQNG@1239|Firmicutes,24AHE@186801|Clostridia,260QC@186807|Peptococcaceae	186801|Clostridia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
DYD2_k127_2358836_17	292459.STH819	2.733e-56	207.0	COG1427@1|root,COG1427@2|Bacteria,1V2PX@1239|Firmicutes,24CGN@186801|Clostridia	186801|Clostridia	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
DYD2_k127_2358836_6	1123242.JH636434_gene5099	1.985e-97	343.0	COG1060@1|root,COG1060@2|Bacteria,2IX1I@203682|Planctomycetes	203682|Planctomycetes	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
DYD2_k127_2358836_7	673860.AciM339_0631	2.289e-96	326.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,3F2F2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
DYD2_k127_2358836_28	693661.Arcve_1550	2.753e-19	103.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y0SK@28890|Euryarchaeota,2476X@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
DYD2_k127_2358836_25	439481.Aboo_0043	1.245e-38	164.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,3F2NC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	trmH	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
DYD2_k127_2358836_3	439481.Aboo_0728	4.958e-162	539.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,3F2FR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0179	HGTP_anticodon,ProRS-C_1,ProRS-C_2,tRNA-synt_2b
DYD2_k127_2358836_9	290397.Adeh_2884	1.587e-90	317.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42SJR@68525|delta/epsilon subdivisions,2WRRB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DYD2_k127_2358836_26	498848.TaqDRAFT_4857	4.043e-35	136.0	COG3118@1|root,COG3118@2|Bacteria,1WK9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DYD2_k127_2358836_24	272844.PAB1236	9.42e-43	162.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX9F@28890|Euryarchaeota,243Z9@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
DYD2_k127_2358836_0	1041930.Mtc_2296	3.504e-243	784.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
DYD2_k127_2358836_12	861299.J421_5582	8.073e-72	256.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DYD2_k127_2358836_14	1123389.ATXJ01000007_gene1732	3.863e-64	235.0	COG0477@1|root,COG0477@2|Bacteria,1WNEQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_2358836_13	1306174.JODP01000013_gene7452	1.078e-65	231.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
DYD2_k127_2358836_11	1089552.KI911559_gene1172	9.142e-80	276.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,2JPUW@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
DYD2_k127_2358836_15	118161.KB235922_gene4288	4.263e-63	236.0	COG4177@1|root,COG4177@2|Bacteria,1G20I@1117|Cyanobacteria,3VJD4@52604|Pleurocapsales	1117|Cyanobacteria	U	PFAM Branched-chain amino acid transport system permease component	natC	-	-	ko:K01998,ko:K11955	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2
DYD2_k127_2358836_18	1245475.ANAE01000125_gene512	2.727e-52	209.0	COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4EI3V@85012|Streptosporangiales	201174|Actinobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997,ko:K11956	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	BPD_transp_2,CarboxypepD_reg
DYD2_k127_2358836_20	335543.Sfum_0454	3.616e-51	190.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2WNP9@28221|Deltaproteobacteria,2MRKX@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DYD2_k127_2358836_5	1293048.CBMB010000005_gene2715	3.48e-102	347.0	COG0031@1|root,arCOG01430@2157|Archaea,2Y2Y8@28890|Euryarchaeota,23Z1R@183963|Halobacteria	183963|Halobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_2358836_1	673860.AciM339_0062	5.393e-204	651.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,3F2FJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
DYD2_k127_2358836_4	572546.Arcpr_0661	5.928e-117	391.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,245NS@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
DYD2_k127_2358836_27	1187851.A33M_4182	1.208e-33	144.0	COG1975@1|root,COG1975@2|Bacteria,1MWFN@1224|Proteobacteria,2TS6Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	coxF	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
DYD2_k127_2358836_19	754035.Mesau_02467	2.737e-51	186.0	COG2080@1|root,COG2080@2|Bacteria,1RFP6@1224|Proteobacteria,2U75E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	2Fe-2S -binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
DYD2_k127_2358836_2	485913.Krac_2434	7.154e-200	652.0	COG1529@1|root,COG1529@2|Bacteria,2G5NF@200795|Chloroflexi	2|Bacteria	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
DYD2_k127_2358836_16	767817.Desgi_0418	4.488e-61	224.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,264MQ@186807|Peptococcaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM-like protein	-	-	1.17.1.4,1.2.5.3	ko:K03519,ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
DYD2_k127_2358836_30	1229205.BUPH_02910	3.275e-07	61.0	2DBRF@1|root,2ZAKB@2|Bacteria,1N3FC@1224|Proteobacteria,2VW6D@28216|Betaproteobacteria,1K14F@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2358836_22	1048834.TC41_0813	7.619e-47	180.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_2358836_31	1048339.KB913029_gene17	4.043e-06	58.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2358836_10	391625.PPSIR1_25066	5.836e-84	291.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42PBC@68525|delta/epsilon subdivisions,2WM7S@28221|Deltaproteobacteria,2YY2B@29|Myxococcales	28221|Deltaproteobacteria	C	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_2358836_29	1463885.KL578355_gene10263	6.25e-08	65.0	COG0346@1|root,COG0346@2|Bacteria,2IHZH@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	gloA	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
DYD2_k127_2358836_23	1455608.JDTH01000002_gene713	2.73e-44	168.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,23SMM@183963|Halobacteria	183963|Halobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	ech4	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_2364001_8	671143.DAMO_1611	6.583e-59	215.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
DYD2_k127_2364001_19	572546.Arcpr_1099	2.267e-08	61.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,246CG@183980|Archaeoglobi	183980|Archaeoglobi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
DYD2_k127_2364001_20	1250232.JQNJ01000001_gene2823	3.183e-08	66.0	COG3360@1|root,COG3360@2|Bacteria,4NURJ@976|Bacteroidetes	976|Bacteroidetes	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
DYD2_k127_2364001_7	3218.PP1S46_300V6.1	2.214e-73	267.0	COG0667@1|root,2S0PI@2759|Eukaryota,37UGN@33090|Viridiplantae,3GP0T@35493|Streptophyta	35493|Streptophyta	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DYD2_k127_2364001_4	1961.JOAK01000048_gene5786	5.565e-95	326.0	COG2041@1|root,COG2041@2|Bacteria,2I8PJ@201174|Actinobacteria	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
DYD2_k127_2364001_18	224325.AF_1111	7.263e-10	66.0	COG4004@1|root,arCOG04412@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2364001_15	1197130.BAFM01000006_gene1200	3.419e-24	111.0	arCOG04522@1|root,arCOG04522@2157|Archaea,2XTU5@28890|Euryarchaeota,23U1D@183963|Halobacteria	183963|Halobacteria	O	cytochrome c biogenesis protein	dsbD	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
DYD2_k127_2364001_12	1035308.AQYY01000002_gene199	3.703e-28	125.0	2ANM6@1|root,31DKG@2|Bacteria,1TUK2@1239|Firmicutes,25I50@186801|Clostridia,2668F@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2364001_11	1317118.ATO8_19464	5.094e-35	154.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,4KNGI@93682|Roseivivax	28211|Alphaproteobacteria	S	Peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_2364001_14	1122237.AUGQ01000053_gene8	2.15e-27	115.0	COG1694@1|root,COG1694@2|Bacteria,2IKRC@201174|Actinobacteria,4FPS0@85023|Microbacteriaceae	201174|Actinobacteria	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
DYD2_k127_2364001_21	886293.Sinac_5473	0.0006569	53.0	COG3291@1|root,COG3401@1|root,COG3291@2|Bacteria,COG3401@2|Bacteria,2J1GZ@203682|Planctomycetes	203682|Planctomycetes	U	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
DYD2_k127_2364001_0	867903.ThesuDRAFT_01087	2.217e-222	696.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes	1239|Firmicutes	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
DYD2_k127_2364001_1	604331.AUHY01000058_gene1346	4.306e-207	657.0	COG2225@1|root,COG2225@2|Bacteria,1WIVZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
DYD2_k127_2364001_5	272557.APE_2516	6.873e-87	298.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPS7@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_2364001_9	272557.APE_2514	1.274e-56	221.0	COG0842@1|root,arCOG01465@2157|Archaea,2XQB0@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DYD2_k127_2364001_3	65393.PCC7424_4469	2.525e-110	369.0	COG1028@1|root,COG1028@2|Bacteria,1G3EX@1117|Cyanobacteria	1117|Cyanobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DYD2_k127_2364001_17	69014.TK2028	3.644e-11	75.0	COG0842@1|root,arCOG01465@2157|Archaea,2Y2BQ@28890|Euryarchaeota,243PC@183968|Thermococci	183968|Thermococci	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DYD2_k127_2364001_2	269797.Mbar_A2126	4.962e-130	457.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
DYD2_k127_2364001_16	224325.AF_1564	1.89e-11	71.0	COG3398@1|root,arCOG02611@2157|Archaea,2XZ7M@28890|Euryarchaeota,246E6@183980|Archaeoglobi	183980|Archaeoglobi	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_2364001_10	1054217.TALC_01430	1.077e-54	201.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,241VH@183967|Thermoplasmata	183967|Thermoplasmata	J	Ribosomal RNA adenine dimethylases	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
DYD2_k127_2364001_13	222534.KB893719_gene989	4.134e-28	123.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4ESWI@85013|Frankiales	201174|Actinobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DYD2_k127_2364001_6	1094980.Mpsy_1230	7.69e-85	296.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
DYD2_k127_236456_10	1033730.CAHG01000014_gene1779	1.83e-17	94.0	COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
DYD2_k127_236456_5	1041930.Mtc_0662	2.423e-49	198.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
DYD2_k127_236456_6	584708.Apau_0556	4.659e-44	173.0	COG1533@1|root,COG1533@2|Bacteria,3TBCX@508458|Synergistetes	508458|Synergistetes	L	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DYD2_k127_236456_11	1267535.KB906767_gene4236	7.093e-13	79.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DYD2_k127_236456_7	1235790.C805_01190	1.269e-31	137.0	COG1432@1|root,COG1432@2|Bacteria,1TTAC@1239|Firmicutes,249NE@186801|Clostridia,25W8V@186806|Eubacteriaceae	186801|Clostridia	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
DYD2_k127_236456_0	644966.Tmar_1638	3.233e-173	565.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WCWS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
DYD2_k127_236456_12	933801.Ahos_2329	1.144e-12	77.0	COG3357@1|root,arCOG04479@2157|Archaea,2XR5D@28889|Crenarchaeota	28889|Crenarchaeota	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_236456_8	1168065.DOK_17735	1.693e-27	125.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,DUF2048,Peptidase_S9
DYD2_k127_236456_9	867845.KI911784_gene363	4.822e-21	102.0	COG0824@1|root,COG0824@2|Bacteria,2G7HH@200795|Chloroflexi,377ME@32061|Chloroflexia	32061|Chloroflexia	S	PFAM thioesterase superfamily protein	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
DYD2_k127_236456_13	365044.Pnap_2723	2.335e-11	75.0	COG0454@1|root,COG0454@2|Bacteria,1MVVG@1224|Proteobacteria,2VPZT@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_236456_2	2340.JV46_06460	1.295e-94	325.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1J4FX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905	DALR_2,tRNA-synt_1e,tRNA-synt_1g
DYD2_k127_236456_1	1094980.Mpsy_2726	1.601e-98	327.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
DYD2_k127_236456_4	868131.MSWAN_0459	1.226e-62	238.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,23NNI@183925|Methanobacteria	183925|Methanobacteria	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
DYD2_k127_236456_3	1236689.MMALV_02990	4.584e-64	233.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,3F2JY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_1,KH_6,S1
DYD2_k127_2368375_7	1381123.AYOD01000042_gene2136	1.533e-12	73.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,2UFCS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
DYD2_k127_2368375_6	272569.rrnAC2386	2.099e-18	94.0	arCOG01449@1|root,arCOG01449@2157|Archaea,2XSVU@28890|Euryarchaeota,23T0K@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas02710
DYD2_k127_2368375_5	1236689.MMALV_00410	9.526e-26	110.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,3F2TA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Uncharacterised protein family (UPF0147)	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
DYD2_k127_2368375_1	202952.BBLI01000001_gene12	5.573e-59	215.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,3NIYT@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
DYD2_k127_2368375_2	572478.Vdis_2282	2.682e-54	203.0	COG2086@1|root,arCOG00446@2157|Archaea,2XQVP@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
DYD2_k127_2368375_3	1137269.AZWL01000006_gene6786	2.44e-41	162.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DYD2_k127_2368375_9	572478.Vdis_0010	6.828e-11	67.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	HTH_45
DYD2_k127_2368375_0	865861.AZSU01000002_gene3065	8.962e-98	332.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	-	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
DYD2_k127_2368375_4	290397.Adeh_2796	1.012e-32	147.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4384,PEGA,Pkinase,TPR_12
DYD2_k127_2368375_8	928724.SacglDRAFT_00095	7.499e-12	69.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4E2PP@85010|Pseudonocardiales	201174|Actinobacteria	T	(FHA) domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
DYD2_k127_2384146_4	1035308.AQYY01000001_gene3072	1.78e-56	219.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,2494Z@186801|Clostridia,260B2@186807|Peptococcaceae	186801|Clostridia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15760	Porphobil_deam,Porphobil_deamC
DYD2_k127_2384146_1	526227.Mesil_2986	3.434e-111	391.0	COG0113@1|root,COG0113@2|Bacteria,1WINH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
DYD2_k127_2384146_0	644966.Tmar_2245	2.242e-114	405.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,3WCHX@538999|Clostridiales incertae sedis	186801|Clostridia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DYD2_k127_2384146_2	324602.Caur_2597	1.883e-85	306.0	COG0407@1|root,COG0407@2|Bacteria,2G5NU@200795|Chloroflexi,37564@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
DYD2_k127_2384146_3	716544.wcw_1767	1.487e-67	249.0	COG0408@1|root,COG0408@2|Bacteria,2JFJY@204428|Chlamydiae	204428|Chlamydiae	H	Coproporphyrinogen III oxidase	hemF	-	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
DYD2_k127_2384146_5	589865.DaAHT2_0002	5.389e-51	198.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
DYD2_k127_2384951_3	84531.JMTZ01000014_gene2827	2.338e-43	179.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X8D9@135614|Xanthomonadales	135614|Xanthomonadales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_2384951_0	1869.MB27_12305	2.011e-98	330.0	COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria,4DMD2@85008|Micromonosporales	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran,DUF4162
DYD2_k127_2384951_4	469383.Cwoe_5525	4.194e-38	154.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4CTMT@84995|Rubrobacteria	84995|Rubrobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
DYD2_k127_2384951_5	644966.Tmar_0540	2.492e-32	135.0	COG2258@1|root,COG2258@2|Bacteria	2|Bacteria	C	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
DYD2_k127_2384951_1	645991.Sgly_0856	3.958e-67	249.0	COG0644@1|root,COG0644@2|Bacteria,1TRTQ@1239|Firmicutes,24E1W@186801|Clostridia,261F2@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
DYD2_k127_2384951_6	1183377.Py04_1433	5.075e-32	141.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
DYD2_k127_2384951_2	644966.Tmar_0122	2.811e-44	167.0	COG2096@1|root,COG2096@2|Bacteria,1V3PI@1239|Firmicutes,24C7G@186801|Clostridia	186801|Clostridia	S	ATP cob(I)alamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
DYD2_k127_2384951_7	1123257.AUFV01000003_gene1014	1.219e-19	96.0	COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,1X7VA@135614|Xanthomonadales	135614|Xanthomonadales	L	Cysteine methyltransferase	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
DYD2_k127_2384951_8	66874.JOFS01000049_gene3200	5.686e-06	53.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_2399512_32	935836.JAEL01000020_gene1024	0.0001428	55.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,4HAZA@91061|Bacilli,1ZAZK@1386|Bacillus	91061|Bacilli	O	Belongs to the peptidase S8 family	aprX	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
DYD2_k127_2399512_26	1380356.JNIK01000011_gene1633	1.143e-08	68.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4EX5J@85013|Frankiales	201174|Actinobacteria	S	Laminin G domain	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
DYD2_k127_2399512_22	1382306.JNIM01000001_gene2847	2.222e-15	91.0	COG4911@1|root,COG4911@2|Bacteria,2G7A8@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
DYD2_k127_2399512_10	1268622.AVS7_03081	4.802e-62	230.0	COG3829@1|root,COG3920@1|root,COG5002@1|root,COG3829@2|Bacteria,COG3920@2|Bacteria,COG5002@2|Bacteria,1MVPJ@1224|Proteobacteria,2VN2J@28216|Betaproteobacteria,4AEHS@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,PAS,PAS_4,PAS_9
DYD2_k127_2399512_20	1340493.JNIF01000003_gene4236	5.517e-29	132.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25
DYD2_k127_2399512_0	886293.Sinac_1689	1.866e-245	788.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
DYD2_k127_2399512_18	1279009.ADICEAN_03832	2.456e-35	144.0	COG3358@1|root,COG3358@2|Bacteria,4NNWJ@976|Bacteroidetes,47Q5N@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
DYD2_k127_2399512_5	573063.Metin_0677	1.605e-92	321.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,23QME@183939|Methanococci	183939|Methanococci	E	Belongs to the aspartokinase family	-	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
DYD2_k127_2399512_12	502025.Hoch_6599	7.23e-61	234.0	COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1QA4K@1224|Proteobacteria,42V3B@68525|delta/epsilon subdivisions,2WRIN@28221|Deltaproteobacteria,2YW0I@29|Myxococcales	28221|Deltaproteobacteria	E	Prephenate dehydrogenase chorismate mutase	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
DYD2_k127_2399512_4	1232428.CAVO010000136_gene81	1.225e-96	339.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4H375@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
DYD2_k127_2399512_3	1227457.C451_08388	3.555e-106	368.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,23S46@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
DYD2_k127_2399512_17	593117.TGAM_1594	2.886e-40	170.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,243I7@183968|Thermococci	183968|Thermococci	E	shikimate kinase activity	aroK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
DYD2_k127_2399512_13	926566.Terro_1054	8.58e-55	211.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,3Y2Y4@57723|Acidobacteria,2JI8D@204432|Acidobacteriia	204432|Acidobacteriia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
DYD2_k127_2399512_8	1054217.TALC_00561	1.901e-73	276.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
DYD2_k127_2399512_6	1094980.Mpsy_1418	1.334e-77	270.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N9E2@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroF	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0920	DeoC
DYD2_k127_2399512_19	269797.Mbar_A2169	6.187e-34	141.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,2N9NE@224756|Methanomicrobia	224756|Methanomicrobia	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_2399512_16	263820.PTO0129	1.339e-44	175.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,241PW@183967|Thermoplasmata	183967|Thermoplasmata	F	nicotinamide-nucleotide adenylyltransferase activity	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
DYD2_k127_2399512_33	368407.Memar_1756	0.0002091	52.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24
DYD2_k127_2399512_21	634497.HAH_2517	3.214e-19	96.0	arCOG06302@1|root,arCOG06302@2157|Archaea,2Y0EF@28890|Euryarchaeota,23XJG@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CopD,DUF2214
DYD2_k127_2399512_31	1448860.BBJO01000013_gene1009	5.762e-05	51.0	arCOG11098@1|root,arCOG11098@2157|Archaea,2Y1XB@28890|Euryarchaeota,23YK2@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2399512_30	391037.Sare_4667	1.801e-05	51.0	2E8I5@1|root,332W5@2|Bacteria,2GRF8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2399512_24	391037.Sare_0075	8.402e-13	81.0	COG2234@1|root,COG3227@1|root,COG4935@1|root,COG2234@2|Bacteria,COG3227@2|Bacteria,COG4935@2|Bacteria,2GIT0@201174|Actinobacteria,4DB7I@85008|Micromonosporales	201174|Actinobacteria	E	Thermolysin metallopeptidase, catalytic domain	-	-	3.4.11.24	ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	FTP,P_proprotein,Peptidase_M28,Peptidase_M4,Peptidase_M4_C
DYD2_k127_2399512_29	1048339.KB913029_gene2918	7.064e-06	58.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2399512_28	693661.Arcve_1813	1.777e-08	63.0	COG0640@1|root,arCOG01683@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_20,HTH_24,HTH_5,PadR
DYD2_k127_2399512_25	269797.Mbar_A1424	4.047e-11	75.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,2NA2R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
DYD2_k127_2399512_2	1379698.RBG1_1C00001G1269	3.261e-157	511.0	COG0433@1|root,COG0433@2|Bacteria,2NPZD@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function DUF87	-	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853,DUF87,PLDc_2
DYD2_k127_2399512_9	1379698.RBG1_1C00001G1268	2.811e-69	250.0	COG0420@1|root,COG0420@2|Bacteria,2NQ16@2323|unclassified Bacteria	2|Bacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	3.1.1.53	ko:K03547,ko:K05970	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Metallophos,Metallophos_2
DYD2_k127_2399512_7	1379698.RBG1_1C00001G1267	1.443e-73	280.0	COG0419@1|root,COG0419@2|Bacteria,2NPX7@2323|unclassified Bacteria	2|Bacteria	L	Putative exonuclease SbcCD, C subunit	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,Rad50_zn_hook,SMC_N,SbcCD_C
DYD2_k127_2399512_23	1828.JOKB01000045_gene3703	6.638e-14	81.0	2EKMV@1|root,33EBK@2|Bacteria,2GY28@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2399512_1	1227453.C444_00957	1.219e-194	632.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,23SII@183963|Halobacteria	183963|Halobacteria	L	ATPase involved in replication control, Cdc46 Mcm family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,HTH_31,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB
DYD2_k127_2399512_15	304371.MCP_0141	4.76e-45	183.0	COG1801@1|root,arCOG04291@2157|Archaea,2XY6C@28890|Euryarchaeota,2NA4H@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
DYD2_k127_2399512_27	89187.ISM_02835	1.519e-08	64.0	COG1280@1|root,COG1280@2|Bacteria,1NDKR@1224|Proteobacteria,2V81W@28211|Alphaproteobacteria,46RU2@74030|Roseovarius	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
DYD2_k127_2399512_11	666510.ASAC_0823	7.65e-62	228.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
DYD2_k127_2399512_14	304371.MCP_0143	2.383e-48	196.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,2N9R4@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_2408741_12	940282.CADQ01000013_gene2584	7.176e-07	53.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,2JU6S@204441|Rhodospirillales	204441|Rhodospirillales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
DYD2_k127_2408741_11	1122225.AULQ01000005_gene2411	2.102e-07	63.0	COG0668@1|root,COG0668@2|Bacteria,4NEPW@976|Bacteroidetes,1HXEP@117743|Flavobacteriia	976|Bacteroidetes	M	mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
DYD2_k127_2408741_3	368407.Memar_2034	2.961e-76	277.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2408741_10	309800.C498_16239	8.562e-10	68.0	COG3467@1|root,arCOG00512@2157|Archaea,2XYBG@28890|Euryarchaeota,23X58@183963|Halobacteria	183963|Halobacteria	S	flavin-nucleotide-binding protein	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
DYD2_k127_2408741_0	1227457.C451_16765	4.461e-199	644.0	COG4799@1|root,arCOG02705@2157|Archaea,2XUNE@28890|Euryarchaeota,23U1N@183963|Halobacteria	183963|Halobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB1	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
DYD2_k127_2408741_4	593117.TGAM_0168	3.495e-55	199.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,243RS@183968|Thermococci	183968|Thermococci	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
DYD2_k127_2408741_13	1463855.JOHV01000015_gene3814	9.228e-05	53.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2GKEU@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K21397	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl
DYD2_k127_2408741_7	1157635.KB892002_gene3988	5.893e-38	164.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
DYD2_k127_2408741_5	28444.JODQ01000012_gene3307	3.198e-50	185.0	2C3A2@1|root,2ZZP3@2|Bacteria,2I9BD@201174|Actinobacteria,4EJ3U@85012|Streptosporangiales	201174|Actinobacteria	S	PFAM DoxX family protein	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
DYD2_k127_2408741_8	1128421.JAGA01000003_gene2819	2.261e-27	117.0	COG5637@1|root,COG5637@2|Bacteria,2NRUC@2323|unclassified Bacteria	2|Bacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892,Polyketide_cyc
DYD2_k127_2408741_1	673860.AciM339_0381	3.403e-147	484.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,3F2H7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	LT	Protein kinase domain	kae1	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234,2.7.11.1	ko:K08851,ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,Pkinase,RIO1
DYD2_k127_2408741_2	456442.Mboo_0194	4.844e-77	273.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,2N9EI@224756|Methanomicrobia	224756|Methanomicrobia	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
DYD2_k127_2408741_9	926690.KE386573_gene1099	3.177e-10	74.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
DYD2_k127_2408741_6	1236689.MMALV_16390	1.616e-39	154.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
DYD2_k127_2411100_1	562970.Btus_0827	6.252e-104	350.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,4HATY@91061|Bacilli,27910@186823|Alicyclobacillaceae	91061|Bacilli	M	UTP-glucose-1-phosphate uridylyltransferase	yngB	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DYD2_k127_2411100_0	290397.Adeh_1955	3.547e-121	408.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2WJDT@28221|Deltaproteobacteria,2YU9G@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD-dependent epimerase dehydratase	rmlB2	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
DYD2_k127_2411100_2	1042326.AZNV01000002_gene4755	1.104e-26	125.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,4B9FY@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	algD	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
DYD2_k127_2549627_1	290397.Adeh_3915	1.041e-131	429.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
DYD2_k127_2549627_3	1132509.C447_13612	6.231e-112	385.0	COG0842@1|root,arCOG01467@2157|Archaea,2XZAA@28890|Euryarchaeota,23ZEN@183963|Halobacteria	183963|Halobacteria	V	COG0842 ABC-type multidrug transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
DYD2_k127_2549627_7	1087448.Eab7_2302	3.519e-08	64.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli	91061|Bacilli	D	Alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
DYD2_k127_2549627_8	1122989.KB898580_gene1580	9.87e-08	60.0	COG1733@1|root,COG1733@2|Bacteria,4NQWK@976|Bacteroidetes,2FT56@200643|Bacteroidia	976|Bacteroidetes	K	Transcriptional regulator, HxlR family	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
DYD2_k127_2549627_5	1459636.NTE_03061	9.459e-70	244.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DYD2_k127_2549627_2	1121378.KB899704_gene2420	4.339e-115	380.0	COG2132@1|root,COG2132@2|Bacteria,1WJQI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
DYD2_k127_2549627_4	717606.PaecuDRAFT_0821	6.837e-73	272.0	COG0428@1|root,COG0428@2|Bacteria,1V1T7@1239|Firmicutes,4HG8N@91061|Bacilli,26Y9F@186822|Paenibacillaceae	91061|Bacilli	P	ZIP Zinc transporter	-	-	-	-	-	-	-	-	-	-	-	-	Zip
DYD2_k127_2549627_6	1114964.L485_00425	4.841e-09	61.0	COG1401@1|root,COG1401@2|Bacteria,1MYQM@1224|Proteobacteria,2TT5S@28211|Alphaproteobacteria,2K23G@204457|Sphingomonadales	204457|Sphingomonadales	V	AAA domain (dynein-related subfamily)	-	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	AAA_5
DYD2_k127_2549627_9	368407.Memar_2502	1.413e-06	62.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,2N9VU@224756|Methanomicrobia	224756|Methanomicrobia	S	KEOPS complex Cgi121-like subunit	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
DYD2_k127_2549627_0	351160.RCIX575	5.912e-177	581.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
DYD2_k127_2550027_5	1297863.APJF01000021_gene82	1.384e-05	55.0	COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,2U04Y@28211|Alphaproteobacteria,3JSQ8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	-	-	3.6.1.27	ko:K03975,ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LssY_C,PAP2,SNARE_assoc
DYD2_k127_2550027_0	1254432.SCE1572_20180	3.212e-129	459.0	COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,MHYT,PAS,PAS_3,PAS_4,PAS_9,dCache_1
DYD2_k127_2550027_3	1173026.Glo7428_1117	5.038e-67	230.0	COG0784@1|root,COG0784@2|Bacteria,1G63B@1117|Cyanobacteria	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_2550027_2	1173027.Mic7113_4146	2.846e-71	271.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G0GI@1117|Cyanobacteria,1H9N1@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
DYD2_k127_2550027_1	1173027.Mic7113_2544	2.13e-86	298.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
DYD2_k127_2559489_11	756883.Halar_3131	4.061e-12	79.0	arCOG13025@1|root,arCOG13025@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2559489_7	797114.C475_21459	3.35e-52	194.0	COG4711@1|root,2N5UW@2157|Archaea,2XXT6@28890|Euryarchaeota,23W7M@183963|Halobacteria	183963|Halobacteria	S	Putative integral membrane protein (DUF2391)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2391
DYD2_k127_2559489_12	1121440.AUMA01000007_gene1274	9.892e-05	51.0	COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2WP3N@28221|Deltaproteobacteria,2MC0F@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
DYD2_k127_2559489_3	348780.NP_4214A	2.544e-79	298.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT3H@28890|Euryarchaeota,23TZK@183963|Halobacteria	183963|Halobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_2559489_4	292415.Tbd_1193	5.772e-69	257.0	COG3852@1|root,COG4251@1|root,COG3852@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQJ3@28216|Betaproteobacteria,1KSXU@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
DYD2_k127_2559489_8	309800.C498_12928	3.757e-31	130.0	COG1225@1|root,arCOG00310@2157|Archaea,2XXB2@28890|Euryarchaeota,23VSA@183963|Halobacteria	183963|Halobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp-1	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
DYD2_k127_2559489_9	309800.C498_12928	2.21e-30	138.0	COG1225@1|root,arCOG00310@2157|Archaea,2XXB2@28890|Euryarchaeota,23VSA@183963|Halobacteria	183963|Halobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp-1	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
DYD2_k127_2559489_10	649638.Trad_0034	6.606e-23	107.0	COG2151@1|root,COG2151@2|Bacteria,1WK4T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG2151 metal-sulfur cluster biosynthetic protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
DYD2_k127_2559489_0	673860.AciM339_0085	5.162e-137	451.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,3F2HD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
DYD2_k127_2559489_13	391735.Veis_2530	0.0007214	53.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,2VK8T@28216|Betaproteobacteria,4AI35@80864|Comamonadaceae	28216|Betaproteobacteria	M	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DYD2_k127_2559489_6	1268237.G114_14851	1.646e-55	203.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
DYD2_k127_2559489_1	1128421.JAGA01000002_gene991	2.519e-119	436.0	COG1793@1|root,COG1793@2|Bacteria,2NPKI@2323|unclassified Bacteria	2|Bacteria	L	ATP dependent DNA ligase C terminal region	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
DYD2_k127_2559489_5	583355.Caka_2456	4.558e-62	233.0	COG1236@1|root,COG1236@2|Bacteria,46SCR@74201|Verrucomicrobia,3K8YZ@414999|Opitutae	414999|Opitutae	F	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K07577,ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	RMMBL
DYD2_k127_2559489_2	1249975.JQLP01000003_gene76	2.511e-84	318.0	COG1361@1|root,COG3266@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1HZAG@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11
DYD2_k127_2586938_2	1191523.MROS_0917	9.178e-126	414.0	COG0137@1|root,COG0137@2|Bacteria	2|Bacteria	E	argininosuccinate synthase activity	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
DYD2_k127_2586938_15	1054217.TALC_00633	6.284e-38	155.0	arCOG01806@1|root,arCOG01806@2157|Archaea,2Y0PI@28890|Euryarchaeota,242EI@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2586938_33	278963.ATWD01000001_gene2533	4.332e-06	56.0	2DIW1@1|root,32UBV@2|Bacteria,3Y5BC@57723|Acidobacteria,2JJSS@204432|Acidobacteriia	204432|Acidobacteriia	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
DYD2_k127_2586938_7	72664.XP_006410532.1	3.851e-105	358.0	COG0162@1|root,KOG2144@2759|Eukaryota,37Y95@33090|Viridiplantae,3GPCW@35493|Streptophyta,3HR61@3699|Brassicales	35493|Streptophyta	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
DYD2_k127_2586938_8	316067.Geob_0010	3.421e-98	353.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,43CA9@68525|delta/epsilon subdivisions,2X7KT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DYD2_k127_2586938_22	1210884.HG799470_gene14542	1.608e-24	121.0	COG2203@1|root,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
DYD2_k127_2586938_6	518766.Rmar_1671	2.695e-111	368.0	COG2897@1|root,COG2897@2|Bacteria,4NF85@976|Bacteroidetes,1FJSZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
DYD2_k127_2586938_31	521011.Mpal_0097	6.526e-07	57.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota,2NBEM@224756|Methanomicrobia	28890|Euryarchaeota	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_2586938_32	186497.PF1794	1.113e-06	59.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,242XH@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
DYD2_k127_2586938_0	378806.STAUR_5417	3.485e-201	660.0	COG2409@1|root,COG2409@2|Bacteria,1R9Z8@1224|Proteobacteria	1224|Proteobacteria	S	MMPL family	ydfJ	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
DYD2_k127_2586938_16	269797.Mbar_A0824	1.999e-36	151.0	COG4885@1|root,arCOG04478@2157|Archaea,2XTQQ@28890|Euryarchaeota,2NANM@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2586938_11	1382306.JNIM01000001_gene1964	2.137e-55	208.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	ycbU	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
DYD2_k127_2586938_19	1068980.ARVW01000001_gene2016	1.446e-29	127.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,4E4DX@85010|Pseudonocardiales	201174|Actinobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
DYD2_k127_2586938_13	290397.Adeh_0928	3.134e-45	186.0	COG0003@1|root,COG0003@2|Bacteria,1PMWP@1224|Proteobacteria,42RUR@68525|delta/epsilon subdivisions,2WNEE@28221|Deltaproteobacteria,2YUU4@29|Myxococcales	28221|Deltaproteobacteria	D	AAA domain	agmR	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
DYD2_k127_2586938_21	644283.Micau_5924	5.475e-26	119.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4DAB7@85008|Micromonosporales	201174|Actinobacteria	P	Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
DYD2_k127_2586938_18	1463825.JNXC01000033_gene1636	7.108e-30	136.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4E43G@85010|Pseudonocardiales	201174|Actinobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
DYD2_k127_2586938_12	1254432.SCE1572_04620	3.381e-48	186.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,43A75@68525|delta/epsilon subdivisions,2X9W3@28221|Deltaproteobacteria,2Z1PF@29|Myxococcales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
DYD2_k127_2586938_29	1121382.JQKG01000021_gene1928	1.178e-09	72.0	COG0640@1|root,COG0640@2|Bacteria,1WKQ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
DYD2_k127_2586938_3	1236689.MMALV_00370	6.336e-125	409.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,3F2I1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAB	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
DYD2_k127_2586938_36	1232410.KI421421_gene3695	0.0004002	53.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,43V4U@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
DYD2_k127_2586938_20	351160.LRC61	5.069e-28	126.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,2N9TM@224756|Methanomicrobia	224756|Methanomicrobia	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
DYD2_k127_2586938_28	1519464.HY22_07025	1.716e-10	72.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
DYD2_k127_2586938_24	1123261.AXDW01000025_gene1759	3.498e-14	79.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S1WE@1236|Gammaproteobacteria,1X9QR@135614|Xanthomonadales	135614|Xanthomonadales	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_2586938_35	1448860.BBJO01000006_gene1564	0.0002644	52.0	COG1378@1|root,arCOG02037@2157|Archaea,2XTSQ@28890|Euryarchaeota,23URK@183963|Halobacteria	183963|Halobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
DYD2_k127_2586938_23	1434929.X946_4823	1.213e-18	96.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,2VIT3@28216|Betaproteobacteria,1K5CY@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
DYD2_k127_2586938_4	572546.Arcpr_0274	2.35e-121	399.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,246QG@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
DYD2_k127_2586938_34	1297742.A176_04987	6.775e-06	58.0	COG1988@1|root,COG1988@2|Bacteria,1N7RW@1224|Proteobacteria,42WGG@68525|delta/epsilon subdivisions,2WSG3@28221|Deltaproteobacteria,2YW5V@29|Myxococcales	28221|Deltaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
DYD2_k127_2586938_14	1041138.KB890223_gene5664	1.368e-44	177.0	COG1807@1|root,COG3829@1|root,COG4251@1|root,COG1807@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2UR9Y@28211|Alphaproteobacteria,4BNTR@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
DYD2_k127_2586938_27	765420.OSCT_0387	1.982e-12	75.0	COG2199@1|root,COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,COG3706@2|Bacteria,2GANJ@200795|Chloroflexi,376V4@32061|Chloroflexia	32061|Chloroflexia	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Hpt,Response_reg,SpoIIE
DYD2_k127_2586938_30	1459636.NTE_03333	3.923e-09	66.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
DYD2_k127_2586938_17	1173027.Mic7113_1716	3.149e-36	145.0	COG1853@1|root,COG1853@2|Bacteria,1G2RV@1117|Cyanobacteria,1H7U3@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DYD2_k127_2586938_1	867903.ThesuDRAFT_01434	2.845e-147	499.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3WDC4@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
DYD2_k127_2586938_9	1089548.KI783301_gene737	2.95e-93	323.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,4HAA4@91061|Bacilli,3WE2P@539002|Bacillales incertae sedis	91061|Bacilli	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
DYD2_k127_2586938_26	994479.GL877880_gene3871	8.793e-14	81.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria,4E8JR@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2586938_5	240016.ABIZ01000001_gene1867	7.701e-112	390.0	COG0475@1|root,COG0475@2|Bacteria,46U4K@74201|Verrucomicrobia,2IV1A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C
DYD2_k127_2586938_10	1122179.KB890429_gene3708	9.99e-84	289.0	COG0498@1|root,COG0498@2|Bacteria,4NKWI@976|Bacteroidetes,1ITTX@117747|Sphingobacteriia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
DYD2_k127_2594475_0	450851.PHZ_p0154	2.336e-21	97.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2KK9G@204458|Caulobacterales	204458|Caulobacterales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_2594475_1	272844.PAB1101	3.269e-16	94.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,242W8@183968|Thermococci	183968|Thermococci	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
DYD2_k127_2623799_6	192952.MM_1107	5.316e-08	64.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,2N9NA@224756|Methanomicrobia	224756|Methanomicrobia	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
DYD2_k127_2623799_3	706587.Desti_0598	1.126e-12	72.0	2EGHB@1|root,33A9F@2|Bacteria,1NGII@1224|Proteobacteria	1224|Proteobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
DYD2_k127_2623799_0	304371.MCP_1763	7.138e-152	488.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,2N934@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ-1	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
DYD2_k127_2623799_9	348780.NP_5326A	3.613e-05	50.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZTH@28890|Euryarchaeota,23XHR@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
DYD2_k127_2623799_2	693661.Arcve_0149	2.87e-38	154.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_2623799_4	1382306.JNIM01000001_gene632	9.086e-10	66.0	COG3729@1|root,COG3729@2|Bacteria	2|Bacteria	D	General stress protein	gsiB	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	AHH,KGG,LEA_5,YjzC
DYD2_k127_2623799_1	416348.Hlac_1853	8.499e-60	219.0	COG0697@1|root,arCOG00271@2157|Archaea,2XTD0@28890|Euryarchaeota,23TNI@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_2623799_7	1343739.PAP_03465	2.215e-05	55.0	COG3413@1|root,arCOG02271@2157|Archaea,2Y21Q@28890|Euryarchaeota,2443T@183968|Thermococci	183968|Thermococci	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
DYD2_k127_2623799_8	768671.ThimaDRAFT_3226	3.019e-05	51.0	COG2198@1|root,COG2198@2|Bacteria,1QN0K@1224|Proteobacteria,1TKC8@1236|Gammaproteobacteria,1X1SV@135613|Chromatiales	135613|Chromatiales	T	Histidine Phosphotransfer domain	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt
DYD2_k127_2623799_5	304371.MCP_1831	4.477e-09	68.0	COG3612@1|root,arCOG04418@2157|Archaea,2XXT8@28890|Euryarchaeota,2NA4A@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
DYD2_k127_2711080_2	386456.JQKN01000005_gene479	3.296e-46	170.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,23PMZ@183925|Methanobacteria	183925|Methanobacteria	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
DYD2_k127_2711080_0	1236689.MMALV_12010	9.378e-103	344.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,3F2F5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
DYD2_k127_2711080_4	935839.JAGJ01000001_gene1053	1.339e-20	95.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DYD2_k127_2711080_5	176299.Atu0677	1.375e-12	79.0	COG0346@1|root,COG0346@2|Bacteria,1N15G@1224|Proteobacteria,2UCYE@28211|Alphaproteobacteria,4BEKA@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
DYD2_k127_2711080_1	1282876.BAOK01000002_gene507	8.155e-72	260.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria	1224|Proteobacteria	V	Mate efflux family protein	yeeO	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006862,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015215,GO:0015230,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0034220,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0044610,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1904680	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
DYD2_k127_2711080_6	1227454.C446_15733	8.465e-07	58.0	COG1403@1|root,arCOG03898@2157|Archaea,2XUHK@28890|Euryarchaeota,23TMW@183963|Halobacteria	183963|Halobacteria	V	COG1403 Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
DYD2_k127_2711080_3	1123368.AUIS01000027_gene1355	5.377e-29	129.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	carbamoyl transferase, NodU family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
DYD2_k127_2748156_17	1123389.ATXJ01000015_gene2325	7.21e-17	82.0	2EC2Y@1|root,3361X@2|Bacteria,1WKKQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM Lysine biosynthesis protein LysW	lysW	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	TF_Zn_Ribbon
DYD2_k127_2748156_21	443143.GM18_0206	7.194e-09	65.0	2E9GQ@1|root,333PU@2|Bacteria,1NBP0@1224|Proteobacteria,4319S@68525|delta/epsilon subdivisions,2WRGY@28221|Deltaproteobacteria,43VF6@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2748156_22	1206744.BAGL01000055_gene1467	0.0001627	53.0	2E8I5@1|root,32UU8@2|Bacteria,2HTVM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2748156_5	1459636.NTE_02324	5.974e-78	280.0	COG1164@1|root,arCOG04758@2157|Archaea	2157|Archaea	E	oligoendopeptidase F	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
DYD2_k127_2748156_19	405948.SACE_1886	3.877e-12	78.0	COG2050@1|root,COG2050@2|Bacteria,2IJ48@201174|Actinobacteria,4E5BE@85010|Pseudonocardiales	201174|Actinobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_2748156_6	498761.HM1_0677	2.84e-57	207.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,24JM5@186801|Clostridia	186801|Clostridia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
DYD2_k127_2748156_16	224325.AF_0766	3.476e-17	90.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota	28890|Euryarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
DYD2_k127_2748156_12	1236689.MMALV_01050	2.502e-29	117.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,3F2S8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
DYD2_k127_2748156_10	1343739.PAP_04680	6.401e-46	168.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
DYD2_k127_2748156_14	304371.MCP_0442	4.299e-23	109.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
DYD2_k127_2748156_11	765869.BDW_09805	2.99e-42	166.0	COG0204@1|root,COG0204@2|Bacteria,1N01J@1224|Proteobacteria,42UM7@68525|delta/epsilon subdivisions,2MURH@213481|Bdellovibrionales,2WQN9@28221|Deltaproteobacteria	213481|Bdellovibrionales	I	PFAM phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
DYD2_k127_2748156_1	573064.Mefer_1149	9.243e-153	502.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,23Q36@183939|Methanococci	183939|Methanococci	K	SMART Elongator protein 3 MiaB NifB	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Acetyltransf_10,Radical_SAM,Radical_SAM_C
DYD2_k127_2748156_2	204669.Acid345_2369	3.752e-124	409.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_2748156_4	1054217.TALC_00715	1.747e-83	293.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,241N6@183967|Thermoplasmata	183967|Thermoplasmata	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
DYD2_k127_2748156_7	266117.Rxyl_2571	3.143e-52	197.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria,4CSZI@84995|Rubrobacteria	84995|Rubrobacteria	S	PFAM Threonyl alanyl tRNA synthetase, SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_SAD
DYD2_k127_2748156_20	68260.JOAY01000017_gene3476	2.104e-10	71.0	COG0500@1|root,COG2226@2|Bacteria,2I1M7@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DYD2_k127_2748156_15	439481.Aboo_0002	7.173e-19	99.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y6XH@28890|Euryarchaeota,3F2QN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
DYD2_k127_2748156_0	234267.Acid_4539	3.856e-301	944.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,3Y6VT@57723|Acidobacteria	57723|Acidobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
DYD2_k127_2748156_8	1123229.AUBC01000028_gene2257	1.596e-48	194.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JR6P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	fixL	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE3,DUF4118,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_9
DYD2_k127_2748156_18	1380391.JIAS01000013_gene3857	2.599e-14	85.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,2JRWJ@204441|Rhodospirillales	204441|Rhodospirillales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
DYD2_k127_2748156_13	358396.C445_11017	9.186e-27	124.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23VJK@183963|Halobacteria	183963|Halobacteria	S	COG1994 Zn-dependent proteases	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2748156_3	1120985.AUMI01000011_gene156	2.336e-113	385.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,4H27S@909932|Negativicutes	909932|Negativicutes	E	amino acid	puuP	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
DYD2_k127_2748156_9	497964.CfE428DRAFT_3318	2.593e-47	183.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
DYD2_k127_2831976_18	368407.Memar_0289	2.038e-09	59.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,2N9IG@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0384	ATP-synt_D
DYD2_k127_2831976_21	1459636.NTE_00576	1.127e-06	58.0	arCOG09752@1|root,arCOG09752@2157|Archaea,41T9M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2831976_9	765420.OSCT_2567	2.686e-29	129.0	COG2267@1|root,COG2267@2|Bacteria,2GAN6@200795|Chloroflexi,376TU@32061|Chloroflexia	32061|Chloroflexia	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
DYD2_k127_2831976_11	1120936.KB907214_gene4284	5.752e-23	115.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4EHYQ@85012|Streptosporangiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
DYD2_k127_2831976_23	748280.NH8B_0245	0.0005623	44.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,2KPI0@206351|Neisseriales	206351|Neisseriales	P	Psort location CytoplasmicMembrane, score	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
DYD2_k127_2831976_16	1223545.GS4_34_00950	2.04e-10	75.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4GAUC@85026|Gordoniaceae	201174|Actinobacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	VWA_2
DYD2_k127_2831976_13	1122221.JHVI01000021_gene2447	2.773e-19	102.0	COG5542@1|root,COG5542@2|Bacteria	2|Bacteria	O	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	GT87,Mannosyl_trans2,PMT_2
DYD2_k127_2831976_15	1869.MB27_12150	2.685e-17	94.0	COG5542@1|root,COG5542@2|Bacteria,2HWIG@201174|Actinobacteria,4DIWB@85008|Micromonosporales	201174|Actinobacteria	S	Mannosyltransferase (PIG-V)	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
DYD2_k127_2831976_17	383372.Rcas_3240	1.267e-09	72.0	COG0464@1|root,COG0464@2|Bacteria,2G642@200795|Chloroflexi,374VH@32061|Chloroflexia	32061|Chloroflexia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
DYD2_k127_2831976_19	1121289.JHVL01000009_gene1471	2.635e-08	58.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	-	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
DYD2_k127_2831976_6	298655.KI912266_gene153	2.669e-63	232.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4ERNP@85013|Frankiales	201174|Actinobacteria	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DYD2_k127_2831976_0	439481.Aboo_1538	5.928e-132	434.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,3F2G6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmm4	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DYD2_k127_2831976_14	234267.Acid_4278	2.496e-17	95.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	3.4.11.10,3.4.11.6	ko:K19701	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
DYD2_k127_2831976_8	1206741.BAFX01000084_gene6270	3.415e-37	157.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2831976_2	1172188.KB911824_gene3399	4.111e-94	327.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2831976_3	1380347.JNII01000005_gene3745	1.368e-93	331.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_2831976_12	1136417.AZWE01000061_gene841	1.286e-19	99.0	COG4244@1|root,COG4244@2|Bacteria,2IRZ2@201174|Actinobacteria,4DF1E@85008|Micromonosporales	201174|Actinobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
DYD2_k127_2831976_7	5679.XP_010699400.1	7.642e-43	181.0	COG0553@1|root,KOG1000@2759|Eukaryota,3XSH6@5653|Kinetoplastida	5653|Kinetoplastida	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
DYD2_k127_2831976_20	675635.Psed_6128	4.329e-08	65.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria,4E8JR@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_2831976_1	240016.ABIZ01000001_gene1867	2.676e-107	378.0	COG0475@1|root,COG0475@2|Bacteria,46U4K@74201|Verrucomicrobia,2IV1A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C
DYD2_k127_2831976_4	797209.ZOD2009_15026	3.917e-80	290.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XWMT@28890|Euryarchaeota,23YZW@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_2831976_10	304371.MCP_1785	2.046e-28	118.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y29I@28890|Euryarchaeota,2NBA7@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
DYD2_k127_2831976_22	797209.ZOD2009_05212	4.688e-06	59.0	COG1714@1|root,arCOG03633@2157|Archaea,2Y0FR@28890|Euryarchaeota,23XUM@183963|Halobacteria	183963|Halobacteria	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
DYD2_k127_2831976_5	662479.C440_01570	5.475e-67	237.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,23SK3@183963|Halobacteria	183963|Halobacteria	I	COG1960 Acyl-CoA dehydrogenases	acdG	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_2859573_1	604354.TSIB_0005	8.707e-63	229.0	COG1216@1|root,arCOG01383@2157|Archaea,2XX17@28890|Euryarchaeota,2450X@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase family 21	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
DYD2_k127_2859573_0	351160.RCIX1460	1.81e-68	246.0	COG0463@1|root,arCOG00894@2157|Archaea,2XVRD@28890|Euryarchaeota,2N9IU@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_2859573_2	529709.PYCH_15050	1.077e-43	182.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
DYD2_k127_2876925_1	291985.CCSI01000003_gene307	1.069e-11	72.0	COG0454@1|root,COG0456@2|Bacteria,1MZIE@1224|Proteobacteria,2UHRP@28211|Alphaproteobacteria,2K5C4@204457|Sphingomonadales	204457|Sphingomonadales	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
DYD2_k127_2876925_0	1054217.TALC_01206	1.154e-110	372.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,241P5@183967|Thermoplasmata	183967|Thermoplasmata	J	histidyl-tRNA aminoacylation	hisS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
DYD2_k127_2912678_4	326427.Cagg_3597	4.743e-95	319.0	COG0189@1|root,COG0189@2|Bacteria,2G5RN@200795|Chloroflexi,374VK@32061|Chloroflexia	32061|Chloroflexia	HJ	PFAM ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
DYD2_k127_2912678_3	1128421.JAGA01000001_gene2380	5.096e-107	369.0	COG0002@1|root,COG0002@2|Bacteria,2NNN5@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily	argC	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DYD2_k127_2912678_5	926554.KI912628_gene2723	1.533e-93	316.0	COG0548@1|root,COG0548@2|Bacteria,1WIHT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the acetylglutamate kinase family. LysZ subfamily	lysZ	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
DYD2_k127_2912678_2	765420.OSCT_0087	4.98e-116	393.0	COG4992@1|root,COG4992@2|Bacteria,2G5SG@200795|Chloroflexi,375D1@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
DYD2_k127_2912678_6	525904.Tter_0317	6.595e-76	271.0	COG0624@1|root,COG0624@2|Bacteria,2NQBR@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	lysK	-	3.5.1.16	ko:K01438,ko:K05831	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R00669,R09107,R09779,R10933	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
DYD2_k127_2912678_7	756272.Plabr_3042	9.671e-45	168.0	COG3476@1|root,COG3476@2|Bacteria,2J03F@203682|Planctomycetes	203682|Planctomycetes	T	PFAM TspO MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
DYD2_k127_2912678_0	1232410.KI421428_gene1065	5.085e-168	542.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,43TW9@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
DYD2_k127_2912678_12	868131.MSWAN_0258	1.584e-07	60.0	COG4978@1|root,arCOG03200@2157|Archaea,2XYDM@28890|Euryarchaeota	28890|Euryarchaeota	K	transcription activator, effector binding	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
DYD2_k127_2912678_11	1267005.KB911263_gene1365	4.552e-08	64.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2UAKC@28211|Alphaproteobacteria,3N72Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
DYD2_k127_2912678_10	439481.Aboo_0090	4.739e-15	80.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75P@28890|Euryarchaeota,3F3FQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
DYD2_k127_2912678_8	266117.Rxyl_0744	2.709e-24	104.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,4CQC7@84995|Rubrobacteria	84995|Rubrobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DYD2_k127_2912678_1	1303518.CCALI_00532	4.21e-157	505.0	COG0476@1|root,COG0607@1|root,COG1977@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.73,2.7.7.80,2.8.1.11	ko:K03148,ko:K03636,ko:K21029,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
DYD2_k127_2912678_9	1313172.YM304_29650	2.505e-15	89.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4CMW0@84992|Acidimicrobiia	84992|Acidimicrobiia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DYD2_k127_2998410_2	1236689.MMALV_10400	1.632e-82	288.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,3F2IJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22
DYD2_k127_2998410_0	1236689.MMALV_01670	3.88e-118	407.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,3F2IN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	HELICc2	rad3b	-	3.6.4.12	ko:K03722,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2,ResIII
DYD2_k127_2998410_4	909663.KI867150_gene1727	3.99e-06	59.0	29YAX@1|root,30K55@2|Bacteria,1NQ6Z@1224|Proteobacteria,42XV0@68525|delta/epsilon subdivisions,2WTAS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DYD2_k127_2998410_5	319225.Plut_1792	4.729e-05	56.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DYD2_k127_2998410_3	1385515.N791_02240	2.258e-60	214.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,1RMFX@1236|Gammaproteobacteria,1X5JH@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
DYD2_k127_2998410_1	1227497.C491_07271	4.376e-110	370.0	COG1902@1|root,arCOG00615@2157|Archaea,2XV80@28890|Euryarchaeota,23T1G@183963|Halobacteria	183963|Halobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	yqjM2	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
DYD2_k127_2998449_0	240016.ABIZ01000001_gene1867	5.53e-124	429.0	COG0475@1|root,COG0475@2|Bacteria,46U4K@74201|Verrucomicrobia,2IV1A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C
DYD2_k127_2998449_2	243274.THEMA_09675	1.254e-09	67.0	COG0517@1|root,COG0517@2|Bacteria,2GE56@200918|Thermotogae	200918|Thermotogae	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DYD2_k127_2998449_1	292459.STH1355	6.025e-67	253.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia	186801|Clostridia	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
DYD2_k127_2998449_3	1086011.HJ01_01706	3.934e-06	58.0	COG1266@1|root,COG1266@2|Bacteria,4NTIG@976|Bacteroidetes,1HXSY@117743|Flavobacteriia,2NVHK@237|Flavobacterium	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
DYD2_k127_3030930_37	673860.AciM339_0730	2.596e-05	57.0	COG4934@1|root,arCOG05978@1|root,arCOG03669@2157|Archaea,arCOG05978@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F38G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ,fn3
DYD2_k127_3030930_18	234267.Acid_4124	6.656e-50	201.0	COG1470@1|root,COG2931@1|root,COG1470@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,CarboxypepD_reg,DUF11,DUF5122,Kelch_1,NPCBM_assoc,VCBS
DYD2_k127_3030930_16	304371.MCP_1526	1.35e-50	197.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_3030930_6	1042877.GQS_01555	1.165e-120	396.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,243N7@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_3030930_36	1210908.HSB1_35150	9.462e-07	64.0	arCOG02488@1|root,arCOG03439@1|root,arCOG02488@2157|Archaea,arCOG03439@2157|Archaea,2XUSW@28890|Euryarchaeota,23TYB@183963|Halobacteria	183963|Halobacteria	S	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3030930_0	1449126.JQKL01000035_gene2186	5.981e-224	757.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,268AK@186813|unclassified Clostridiales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
DYD2_k127_3030930_32	593117.TGAM_2028	3.241e-15	85.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,245M9@183968|Thermococci	183968|Thermococci	C	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
DYD2_k127_3030930_1	1160707.AJIK01000006_gene995	1.749e-141	493.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HARK@91061|Bacilli,26D6P@186818|Planococcaceae	91061|Bacilli	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
DYD2_k127_3030930_33	215803.DB30_6630	3.034e-10	74.0	COG1572@1|root,COG1572@2|Bacteria,1QX4M@1224|Proteobacteria,438T3@68525|delta/epsilon subdivisions,2X3ZN@28221|Deltaproteobacteria,2YXQ8@29|Myxococcales	28221|Deltaproteobacteria	S	Coagulation factor 5/8 C-terminal domain, discoidin domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,F5_F8_type_C
DYD2_k127_3030930_25	358396.C445_18608	6.623e-26	115.0	COG1310@1|root,arCOG01138@2157|Archaea,2XXA9@28890|Euryarchaeota,23VWD@183963|Halobacteria	183963|Halobacteria	S	metal-dependent protease of the PAD1 JAB1 superfamily	jamm1	-	3.4.19.15	ko:K20110	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Prok-JAB
DYD2_k127_3030930_22	1459636.NTE_02294	1.072e-39	157.0	COG1321@1|root,arCOG02100@2157|Archaea,41SQ9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
DYD2_k127_3030930_8	525904.Tter_1314	3.976e-91	323.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47	ko:K12339,ko:K21148	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021	R00897,R03132,R03601,R04859,R10610	RC00020,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_3030930_17	1380347.JNII01000005_gene3745	3.781e-50	197.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_3030930_26	266117.Rxyl_0232	1.906e-24	117.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,2IE8G@201174|Actinobacteria,4CPJ4@84995|Rubrobacteria	84995|Rubrobacteria	I	SNARE associated Golgi protein	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
DYD2_k127_3030930_9	552811.Dehly_0004	1.431e-73	256.0	COG0284@1|root,COG0284@2|Bacteria,2G692@200795|Chloroflexi,34CQ3@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
DYD2_k127_3030930_10	673860.AciM339_0004	2.91e-65	235.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,3F2M6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Arginase family	speB	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DYD2_k127_3030930_23	673860.AciM339_0003	3.135e-38	148.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,3F2PU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
DYD2_k127_3030930_19	1054217.TALC_01451	1.66e-47	181.0	COG0061@1|root,COG0483@1|root,arCOG01348@2157|Archaea,arCOG01349@2157|Archaea,2XTP6@28890|Euryarchaeota,241Q7@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
DYD2_k127_3030930_15	877455.Metbo_2344	6.481e-52	207.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
DYD2_k127_3030930_20	1125863.JAFN01000001_gene2304	1.086e-46	175.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
DYD2_k127_3030930_4	1125863.JAFN01000001_gene886	3.555e-133	438.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42N1P@68525|delta/epsilon subdivisions,2WM2V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_3030930_14	448385.sce5671	3.228e-52	214.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_3030930_12	272844.PAB1587	2.733e-55	201.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y7SP@28890|Euryarchaeota,245KY@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_3030930_27	543632.JOJL01000001_gene7822	1.102e-21	109.0	COG2244@1|root,COG2244@2|Bacteria,2GMYJ@201174|Actinobacteria	201174|Actinobacteria	G	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
DYD2_k127_3030930_31	568768.CM001975_gene1224	2.732e-15	88.0	COG1216@1|root,COG1216@2|Bacteria,1N1TF@1224|Proteobacteria,1RPQU@1236|Gammaproteobacteria,2JBTG@204037|Dickeya	1236|Gammaproteobacteria	S	Glycosyl transferase family 21	rfbN	-	-	ko:K12992	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
DYD2_k127_3030930_38	313628.LNTAR_15742	0.0001061	55.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.13	ko:K01136	ko00531,ko01100,ko04142,map00531,map01100,map04142	M00076,M00078	R07812,R07821	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4976,Sulfatase
DYD2_k127_3030930_34	1123070.KB899258_gene1884	6.602e-10	71.0	2CCWM@1|root,338WR@2|Bacteria,46ZKG@74201|Verrucomicrobia,2IVHM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3030930_11	1463885.KL578489_gene4726	3.539e-65	237.0	COG0438@1|root,COG0438@2|Bacteria,2IBWR@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3030930_21	693661.Arcve_0711	2.397e-40	165.0	COG0438@1|root,arCOG01403@2157|Archaea,2XVAJ@28890|Euryarchaeota,245P8@183980|Archaeoglobi	183980|Archaeoglobi	M	Glycosyltransferase Family 4	-	-	2.4.1.87	ko:K00743	ko00601,map00601	-	R05978,R06169	-	ko00000,ko00001,ko01000,ko01003	-	GT6	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3030930_35	523850.TON_0811	9.373e-07	63.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_3030930_5	1128421.JAGA01000003_gene2811	4.158e-125	413.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_3030930_7	1033802.SSPSH_001085	1.337e-118	393.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the class I fructose-bisphosphate aldolase family	alf1	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
DYD2_k127_3030930_28	1210908.HSB1_21900	2.525e-19	97.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,23S66@183963|Halobacteria	183963|Halobacteria	N	COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases	pibD	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
DYD2_k127_3030930_3	269797.Mbar_A2752	1.679e-135	455.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
DYD2_k127_3030930_30	673860.AciM339_0388	5.944e-16	90.0	COG1522@1|root,arCOG01580@2157|Archaea,2Y746@28890|Euryarchaeota,3F3D8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
DYD2_k127_3030930_2	555079.Toce_1201	5.952e-141	471.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,42FA1@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
DYD2_k127_3030930_24	1459636.NTE_00652	1.159e-34	140.0	COG0494@1|root,arCOG01078@2157|Archaea,41SPS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_3030930_13	1242864.D187_001157	1.171e-52	195.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
DYD2_k127_3030930_29	410359.Pcal_1868	2.259e-18	86.0	arCOG05874@1|root,arCOG05874@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3034609_2	1121272.KB903251_gene859	1.499e-116	396.0	COG2304@1|root,COG4257@1|root,COG2304@2|Bacteria,COG4257@2|Bacteria,2IDJM@201174|Actinobacteria,4DEGK@85008|Micromonosporales	201174|Actinobacteria	V	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HYR,VWA
DYD2_k127_3034609_7	1287116.X734_07935	1.516e-14	87.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,43MH7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_3034609_3	562970.Btus_0192	9.91e-96	322.0	COG0010@1|root,COG0010@2|Bacteria,1TR10@1239|Firmicutes,4HAT5@91061|Bacilli,2784I@186823|Alicyclobacillaceae	91061|Bacilli	E	Belongs to the arginase family	rocF	GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DYD2_k127_3034609_1	1192034.CAP_1904	4.228e-165	529.0	COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria,42RN7@68525|delta/epsilon subdivisions,2WNNX@28221|Deltaproteobacteria,2YUI2@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14,1.2.1.46	ko:K00008,ko:K00148	ko00040,ko00051,ko00625,ko00680,ko01100,ko01120,ko01200,map00040,map00051,map00625,map00680,map01100,map01120,map01200	M00014	R00604,R00875,R01896	RC00085,RC00102,RC00188	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
DYD2_k127_3034609_6	591157.SSLG_01864	2.289e-25	117.0	COG1183@1|root,COG1183@2|Bacteria,2ICZ4@201174|Actinobacteria	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
DYD2_k127_3034609_5	1463934.JOCF01000027_gene7146	1.055e-72	254.0	COG0688@1|root,COG0688@2|Bacteria,2GMMF@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
DYD2_k127_3034609_0	562970.Btus_2429	5.515e-169	544.0	COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,278W0@186823|Alicyclobacillaceae	91061|Bacilli	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DYD2_k127_3034609_4	404589.Anae109_4385	7.856e-74	266.0	COG0491@1|root,COG0494@1|root,COG0491@2|Bacteria,COG0494@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria,2YUWZ@29|Myxococcales	28221|Deltaproteobacteria	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
DYD2_k127_3062861_8	709032.Sulku_2095	3.031e-28	133.0	COG4254@1|root,COG4254@2|Bacteria,1NBPR@1224|Proteobacteria,42SEW@68525|delta/epsilon subdivisions,2YPKM@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
DYD2_k127_3062861_9	330214.NIDE1891	5.402e-25	123.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Cytochrom_C,DUF1080,DUF4132,Pkinase
DYD2_k127_3062861_2	456442.Mboo_0427	1.404e-97	329.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DYD2_k127_3062861_10	203124.Tery_2713	1.232e-14	87.0	COG0477@1|root,COG2814@2|Bacteria,1G1EP@1117|Cyanobacteria,1H878@1150|Oscillatoriales	1117|Cyanobacteria	EGP	Major facilitator superfamily	norA	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
DYD2_k127_3062861_3	246969.TAM4_1049	8.353e-65	251.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
DYD2_k127_3062861_0	339860.Msp_0117	1.744e-143	463.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
DYD2_k127_3062861_1	456442.Mboo_0156	5.364e-133	434.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
DYD2_k127_3062861_7	273116.14324348	1.164e-34	153.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
DYD2_k127_3062861_12	1123322.KB904660_gene1054	2.002e-09	68.0	COG0515@1|root,COG2319@1|root,COG4916@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,COG4916@2|Bacteria,2IBSX@201174|Actinobacteria	201174|Actinobacteria	KLT	GUN4-like	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,TIR_2
DYD2_k127_3062861_14	589924.Ferp_0182	2.007e-08	66.0	COG0582@1|root,arCOG01242@2157|Archaea,2Y83U@28890|Euryarchaeota,246MT@183980|Archaeoglobi	183980|Archaeoglobi	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
DYD2_k127_3062861_11	1123319.AUBE01000015_gene5674	8.784e-10	72.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_3062861_15	1185876.BN8_01058	2.738e-07	64.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
DYD2_k127_3062861_16	1214242.B446_04405	0.0004008	52.0	COG2304@1|root,COG2304@2|Bacteria,2GJRP@201174|Actinobacteria	201174|Actinobacteria	S	tyrosinase	melC2	-	1.14.18.1	ko:K00505	ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916	M00042	R00731,R02078,R02363,R02383,R04693,R04884	RC00046,RC00150,RC00180	ko00000,ko00001,ko00002,ko01000	-	-	-	Tyrosinase
DYD2_k127_3062861_13	1120949.KB903299_gene5953	4.479e-09	69.0	COG4409@1|root,COG4409@2|Bacteria,2GN94@201174|Actinobacteria,4DHJE@85008|Micromonosporales	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
DYD2_k127_3062861_4	673860.AciM339_1190	7.157e-49	178.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,3F2PA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal S13/S15 N-terminal domain	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
DYD2_k127_3062861_6	1071085.KK033115_gene1895	2.14e-36	145.0	COG0492@1|root,arCOG01301@2157|Archaea,2XUTM@28890|Euryarchaeota,23S44@183963|Halobacteria	183963|Halobacteria	O	FAD-dependent pyridine nucleotide-disulfide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
DYD2_k127_3062861_5	1449353.JQMQ01000005_gene4006	5.546e-37	150.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,2NERP@228398|Streptacidiphilus	201174|Actinobacteria	S	Beta-lactamase superfamily domain	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DYD2_k127_3066454_1	1054217.TALC_01570	5.068e-07	60.0	COG2157@1|root,arCOG04175@2157|Archaea	2157|Archaea	J	PFAM Ribosomal LX protein	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
DYD2_k127_3066454_2	1041930.Mtc_0441	7.556e-06	53.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
DYD2_k127_3066454_0	439481.Aboo_1259	2.757e-91	323.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,3F2GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
DYD2_k127_3066454_3	717606.PaecuDRAFT_2033	0.0001653	56.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
DYD2_k127_3124919_0	33876.JNXY01000029_gene2752	4.218e-17	93.0	COG0745@1|root,COG2199@1|root,COG4251@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,2GR2M@201174|Actinobacteria,4DA0G@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DYD2_k127_3124919_1	1121403.AUCV01000001_gene803	2.954e-13	83.0	COG1414@1|root,COG1414@2|Bacteria,1Q48S@1224|Proteobacteria,42YKZ@68525|delta/epsilon subdivisions,2WUID@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
DYD2_k127_3161010_6	589924.Ferp_0823	3.734e-08	60.0	COG1745@1|root,arCOG02254@2157|Archaea,2Y7DF@28890|Euryarchaeota,247A1@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0058	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
DYD2_k127_3161010_7	1385518.N798_08295	0.000184	51.0	COG5549@1|root,COG5549@2|Bacteria,2IJMT@201174|Actinobacteria,4FHC4@85021|Intrasporangiaceae	201174|Actinobacteria	O	PFAM peptidase M10A and M12B, matrixin and adamalysin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
DYD2_k127_3161010_4	444157.Tneu_1865	3.007e-13	82.0	COG0608@1|root,arCOG00424@2157|Archaea,2XPR0@28889|Crenarchaeota	28889|Crenarchaeota	L	phosphoesterase RecJ domain protein	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
DYD2_k127_3161010_5	521011.Mpal_2746	8.325e-11	76.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,2N9A6@224756|Methanomicrobia	224756|Methanomicrobia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
DYD2_k127_3161010_3	621372.ACIH01000199_gene3035	8.134e-21	102.0	COG1011@1|root,COG1011@2|Bacteria,1V7DX@1239|Firmicutes,4HK44@91061|Bacilli,26TNE@186822|Paenibacillaceae	91061|Bacilli	S	Hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
DYD2_k127_3161010_2	1051632.TPY_3687	6.077e-29	133.0	COG1432@1|root,COG1432@2|Bacteria,1VXSP@1239|Firmicutes	1239|Firmicutes	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
DYD2_k127_3161010_1	1293048.CBMB010000004_gene1658	2.455e-66	239.0	COG1992@1|root,arCOG00021@2157|Archaea,2XTP7@28890|Euryarchaeota,23SNG@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN2	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
DYD2_k127_3161010_0	1449126.JQKL01000073_gene3045	5.031e-97	336.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,268U9@186813|unclassified Clostridiales	186801|Clostridia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
DYD2_k127_322494_0	443906.CMM_0825	1.78e-23	113.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
DYD2_k127_322494_1	1191523.MROS_0653	1.48e-13	83.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	3.4.11.10	ko:K05994	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
DYD2_k127_3299507_1	269797.Mbar_A0956	4.488e-85	305.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
DYD2_k127_3299507_2	673860.AciM339_0248	4.159e-76	268.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,3F2I0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
DYD2_k127_3299507_3	1380355.JNIJ01000021_gene3699	8.146e-06	58.0	COG5485@1|root,COG5485@2|Bacteria,1RE0T@1224|Proteobacteria,2U870@28211|Alphaproteobacteria,3K0B7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
DYD2_k127_3299507_0	1183438.GKIL_3693	3.747e-143	467.0	COG3569@1|root,COG3569@2|Bacteria,1G2R6@1117|Cyanobacteria	1117|Cyanobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
DYD2_k127_3359800_4	673860.AciM339_0087	4.306e-35	143.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,3F33U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0042802,GO:0042803,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046983,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
DYD2_k127_3359800_0	240015.ACP_0267	3.739e-160	530.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
DYD2_k127_3359800_3	751944.HALDL1_08235	5.682e-57	214.0	COG0704@1|root,arCOG00318@2157|Archaea,2XT7D@28890|Euryarchaeota,23SX0@183963|Halobacteria	183963|Halobacteria	K	Phosphate uptake regulator	phoU5	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
DYD2_k127_3359800_1	304371.MCP_0130	1.528e-77	264.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
DYD2_k127_3359800_2	304371.MCP_0130	2.422e-74	259.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
DYD2_k127_3359800_5	446470.Snas_4442	1.748e-05	56.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4EYT8@85014|Glycomycetales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
DYD2_k127_3382224_0	263820.PTO0417	2.501e-174	555.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,241J6@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
DYD2_k127_3382224_1	330214.NIDE3226	7.076e-151	510.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
DYD2_k127_3382224_2	351160.RCIX1877	2.594e-125	418.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,2NBG0@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DYD2_k127_3382224_3	439481.Aboo_1303	4.08e-124	421.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,3F2J7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
DYD2_k127_3382224_4	880073.Calab_3350	1.215e-87	306.0	COG0644@1|root,COG0644@2|Bacteria,2NQ4F@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
DYD2_k127_3382224_6	667014.Thein_1835	1.234e-17	96.0	COG4089@1|root,COG4089@2|Bacteria,2GI8X@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
DYD2_k127_3382224_7	215803.DB30_7885	3.128e-13	83.0	COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,4315Y@68525|delta/epsilon subdivisions,2WWQ6@28221|Deltaproteobacteria,2YX8X@29|Myxococcales	28221|Deltaproteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
DYD2_k127_3382224_8	1121286.AUMT01000011_gene2383	0.0002247	54.0	29XNI@1|root,30JDZ@2|Bacteria,4PNE6@976|Bacteroidetes,1IK3Y@117743|Flavobacteriia,3ZS8Z@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3382224_5	1502850.FG91_02185	5.959e-34	131.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TSA0@28211|Alphaproteobacteria,2K081@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_3413713_1	1227487.C474_19409	2.049e-08	64.0	arCOG04662@1|root,arCOG04662@2157|Archaea,2XXQS@28890|Euryarchaeota,23W19@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3413713_0	1242864.D187_006315	1.135e-130	433.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2YTX6@29|Myxococcales	28221|Deltaproteobacteria	E	Cys Met metabolism	metC	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
DYD2_k127_3423189_1	1459636.NTE_03030	1.752e-12	80.0	COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Dual specificity phosphatase, catalytic domain	-	-	3.1.3.16,3.1.3.48	ko:K14165	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	DSPc
DYD2_k127_3423189_0	673860.AciM339_1081	1.168e-122	410.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,3F2N6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	tRNA synthetases class I (W and Y)	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
DYD2_k127_3431437_5	1094980.Mpsy_1862	2.371e-27	115.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,2NA0G@224756|Methanomicrobia	224756|Methanomicrobia	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
DYD2_k127_3431437_3	1236689.MMALV_03080	6.786e-86	304.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,3F2MH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
DYD2_k127_3431437_9	1254432.SCE1572_00410	2.887e-11	75.0	COG4719@1|root,COG4719@2|Bacteria,1R0BA@1224|Proteobacteria,42VBW@68525|delta/epsilon subdivisions,2X811@28221|Deltaproteobacteria,2Z3J2@29|Myxococcales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
DYD2_k127_3431437_7	555079.Toce_0632	8.668e-21	104.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,42GS6@68295|Thermoanaerobacterales	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_3431437_2	1197130.BAFM01000015_gene2520	3.712e-103	346.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,23SXG@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
DYD2_k127_3431437_6	1455608.JDTH01000002_gene466	1.214e-23	109.0	COG1733@1|root,arCOG02600@2157|Archaea,2Y7P4@28890|Euryarchaeota,240UD@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
DYD2_k127_3431437_1	673860.AciM339_1443	2.54e-115	394.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
DYD2_k127_3431437_4	1210884.HG799465_gene11440	4.666e-31	128.0	28WG9@1|root,2ZIGE@2|Bacteria	2|Bacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
DYD2_k127_3431437_8	391623.TERMP_02010	9.149e-16	88.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
DYD2_k127_3431437_0	1041930.Mtc_0057	5.781e-172	548.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,2N93K@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
DYD2_k127_3431437_10	439481.Aboo_0802	1.368e-08	58.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,3F2RJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
DYD2_k127_3434773_5	1192034.CAP_6081	5.502e-100	339.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YV62@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
DYD2_k127_3434773_2	404589.Anae109_1994	7.984e-136	461.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2YTX4@29|Myxococcales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
DYD2_k127_3434773_15	1048339.KB913029_gene3676	0.0002442	53.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3434773_4	661478.OP10G_1531	1.142e-102	350.0	COG0078@1|root,COG4992@1|root,COG0078@2|Bacteria,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	argD	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071941,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3,2.6.1.11,2.6.1.17	ko:K00611,ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00029,M00844,M00845	R01398,R02283,R04475	RC00006,RC00062,RC00096	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,OTCace,OTCace_N
DYD2_k127_3434773_7	242159.ABP00909	1.07e-41	164.0	COG0548@1|root,KOG2436@2759|Eukaryota,37ITD@33090|Viridiplantae,34HGS@3041|Chlorophyta	3041|Chlorophyta	E	Amino acid kinase family	-	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iRC1080.CRv4_Au5_s1_g1272_t1	AA_kinase
DYD2_k127_3434773_3	292459.STH2890	2.563e-113	389.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
DYD2_k127_3434773_6	330214.NIDE2755	1.102e-78	276.0	COG0002@1|root,COG0002@2|Bacteria,3J0H9@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DYD2_k127_3434773_13	1380390.JIAT01000009_gene1878	1.096e-05	50.0	COG4251@1|root,COG4251@2|Bacteria,2GK25@201174|Actinobacteria,4CRRV@84995|Rubrobacteria	84995|Rubrobacteria	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA
DYD2_k127_3434773_8	1337936.IJ00_01765	2.915e-40	166.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1HJUQ@1161|Nostocales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
DYD2_k127_3434773_0	504728.K649_08100	1.828e-267	846.0	COG0474@1|root,COG0474@2|Bacteria,1WICW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.3	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
DYD2_k127_3434773_12	243233.MCA2881	4.938e-09	70.0	COG2865@1|root,COG2865@2|Bacteria,1RDDZ@1224|Proteobacteria,1S277@1236|Gammaproteobacteria,1XGH5@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3434773_9	1172188.KB911824_gene3401	2.913e-15	87.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4FHMW@85021|Intrasporangiaceae	201174|Actinobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DYD2_k127_3434773_14	1250278.JQNQ01000001_gene3057	0.0001199	44.0	COG2972@1|root,COG2972@2|Bacteria,4NFDP@976|Bacteroidetes,1HWNJ@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2TM,His_kinase
DYD2_k127_3434773_1	644966.Tmar_0901	2.891e-188	614.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
DYD2_k127_3434773_10	1227487.C474_12431	2.88e-10	72.0	COG3467@1|root,arCOG00512@2157|Archaea,2XYBG@28890|Euryarchaeota,23X58@183963|Halobacteria	183963|Halobacteria	S	flavin-nucleotide-binding protein	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
DYD2_k127_3434773_11	1114856.C496_03603	8.087e-10	70.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU8P@28890|Euryarchaeota,23UFM@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DYD2_k127_343797_3	234267.Acid_3560	1.408e-07	65.0	COG1409@1|root,COG1409@2|Bacteria,3Y5PM@57723|Acidobacteria	57723|Acidobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DYD2_k127_343797_1	1333523.L593_07400	1.049e-34	153.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,23V6E@183963|Halobacteria	183963|Halobacteria	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
DYD2_k127_343797_2	309801.trd_0313	3.991e-10	69.0	COG2339@1|root,COG2339@2|Bacteria,2GAFJ@200795|Chloroflexi,27Z8G@189775|Thermomicrobia	189775|Thermomicrobia	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
DYD2_k127_343797_4	439481.Aboo_0729	0.0003683	45.0	arCOG05340@1|root,arCOG05340@2157|Archaea,2Y77S@28890|Euryarchaeota,3F3IY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_343797_0	192952.MM_2504	8.113e-106	356.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,2N95Q@224756|Methanomicrobia	224756|Methanomicrobia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
DYD2_k127_3475589_5	404589.Anae109_3548	2.619e-73	272.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
DYD2_k127_3475589_10	3656.XP_008443669.1	0.0007727	50.0	KOG1565@1|root,KOG1565@2759|Eukaryota,37MB0@33090|Viridiplantae,3GFCB@35493|Streptophyta,4JKX4@91835|fabids	35493|Streptophyta	O	metalloendoproteinase 1-like	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,Peptidase_M10
DYD2_k127_3475589_4	765912.Thimo_1862	2.487e-74	269.0	COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,1S0RN@1236|Gammaproteobacteria,1X0GG@135613|Chromatiales	135613|Chromatiales	L	PFAM Uracil-DNA glycosylase superfamily	-	-	-	ko:K10800	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
DYD2_k127_3475589_6	693661.Arcve_0149	9.725e-18	97.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_3475589_8	649747.HMPREF0083_05285	1.976e-11	74.0	COG2217@1|root,COG2217@2|Bacteria,1VJJE@1239|Firmicutes,4HM5J@91061|Bacilli	91061|Bacilli	P	Heavy metal translocating P-type atpase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3475589_7	401053.AciPR4_2101	1.544e-17	97.0	COG1520@1|root,COG2273@1|root,COG2755@1|root,COG3291@1|root,COG4733@1|root,COG1520@2|Bacteria,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,3Y6W7@57723|Acidobacteria,2JMC2@204432|Acidobacteriia	204432|Acidobacteriia	G	Fibronectin type III	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Laminin_G_3,Malectin,fn3
DYD2_k127_3475589_2	1380347.JNII01000005_gene3745	4.275e-91	325.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_3475589_1	1380347.JNII01000005_gene3745	2.662e-94	336.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_3475589_0	1380347.JNII01000005_gene3745	2.678e-98	336.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_3475589_3	671143.DAMO_0390	2.177e-85	296.0	COG0389@1|root,COG0389@2|Bacteria,2NP5S@2323|unclassified Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346,ko:K14161	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
DYD2_k127_3475589_9	405948.SACE_4215	7.37e-06	56.0	COG0500@1|root,COG0500@2|Bacteria,2I3FS@201174|Actinobacteria,4EE49@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
DYD2_k127_349400_5	1166018.FAES_1336	5.171e-36	159.0	COG0457@1|root,COG0457@2|Bacteria	1166018.FAES_1336|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_349400_3	448385.sce7139	7.11e-38	163.0	COG0778@1|root,COG0778@2|Bacteria,1RJMP@1224|Proteobacteria,43BDS@68525|delta/epsilon subdivisions,2X6SC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DYD2_k127_349400_2	55207.KP22_09760	3.723e-103	352.0	COG1944@1|root,COG1944@2|Bacteria,1N4UP@1224|Proteobacteria,1SASC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	ThiF,YcaO
DYD2_k127_349400_4	55207.KP22_09765	6.455e-37	156.0	COG1944@1|root,COG1944@2|Bacteria,1P453@1224|Proteobacteria	1224|Proteobacteria	S	ATP diphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_349400_0	1122604.JONR01000026_gene3005	2.435e-169	541.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,1X41K@135614|Xanthomonadales	135614|Xanthomonadales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
DYD2_k127_349400_1	635013.TherJR_2416	7.306e-126	417.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,248TR@186801|Clostridia,2621Y@186807|Peptococcaceae	186801|Clostridia	E	PFAM Beta-eliminating lyase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
DYD2_k127_3511317_0	290397.Adeh_2502	1.988e-45	175.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2WP65@28221|Deltaproteobacteria,2YVJK@29|Myxococcales	28221|Deltaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
DYD2_k127_3511317_2	246969.TAM4_1736	2.526e-06	59.0	COG1967@1|root,arCOG02177@2157|Archaea,2XV37@28890|Euryarchaeota,242MC@183968|Thermococci	183968|Thermococci	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
DYD2_k127_3511317_1	1137271.AZUM01000005_gene294	7.631e-13	78.0	2CFT8@1|root,2ZBMC@2|Bacteria,2IFWU@201174|Actinobacteria,4E1RK@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3532278_4	344747.PM8797T_27919	2.409e-69	242.0	COG1446@1|root,COG1446@2|Bacteria	2|Bacteria	E	asparaginase	-	-	3.4.19.5,3.5.1.1	ko:K01424,ko:K13051	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2
DYD2_k127_3532278_3	1089552.KI911559_gene2231	4.153e-75	272.0	COG4242@1|root,COG4242@2|Bacteria,1PR9J@1224|Proteobacteria,2U4I8@28211|Alphaproteobacteria,2JVEW@204441|Rhodospirillales	204441|Rhodospirillales	PQ	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
DYD2_k127_3532278_0	1089552.KI911559_gene2232	3.053e-312	981.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria,2JSSA@204441|Rhodospirillales	204441|Rhodospirillales	HJ	Cyanophycin synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Mur_ligase_C,Mur_ligase_M,RimK
DYD2_k127_3532278_9	452637.Oter_0196	9.761e-16	92.0	COG3685@1|root,COG3685@2|Bacteria,46VCV@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
DYD2_k127_3532278_7	500635.MITSMUL_03322	4.061e-23	111.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,4H4EK@909932|Negativicutes	909932|Negativicutes	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
DYD2_k127_3532278_2	56780.SYN_01185	6.609e-76	266.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2MQXP@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	Nitro_FeMo-Co,ParA
DYD2_k127_3532278_5	272569.rrnAC2217	7.469e-32	138.0	COG2404@1|root,arCOG00423@2157|Archaea,2XTAE@28890|Euryarchaeota,23STA@183963|Halobacteria	183963|Halobacteria	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_3532278_1	864702.OsccyDRAFT_1508	1.321e-78	285.0	COG0659@1|root,COG0659@2|Bacteria,1G0E3@1117|Cyanobacteria,1H9W8@1150|Oscillatoriales	1117|Cyanobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
DYD2_k127_3532278_10	938709.AUSH02000045_gene451	2.593e-05	58.0	COG2356@1|root,COG2374@1|root,COG2356@2|Bacteria,COG2374@2|Bacteria,4NKW3@976|Bacteroidetes	976|Bacteroidetes	L	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LTD
DYD2_k127_3532278_8	243232.MJ_1398	2.914e-16	89.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_3532278_6	644281.MFS40622_0251	3.407e-23	110.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_3532538_16	931627.MycrhDRAFT_4772	4.251e-27	130.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,235H0@1762|Mycobacteriaceae	201174|Actinobacteria	S	peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_3532538_8	1033806.HTIA_2609	5.344e-59	221.0	COG0697@1|root,arCOG00271@2157|Archaea,2XT64@28890|Euryarchaeota,23TZT@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_3532538_10	883080.HMPREF9697_02191	4.419e-44	187.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TUHU@28211|Alphaproteobacteria,3K0JF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
DYD2_k127_3532538_3	986075.CathTA2_1863	3.447e-92	336.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,4HA7A@91061|Bacilli	91061|Bacilli	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
DYD2_k127_3532538_15	219305.MCAG_00217	2.461e-34	153.0	COG0457@1|root,COG0457@2|Bacteria,2GNB7@201174|Actinobacteria,4DAYE@85008|Micromonosporales	201174|Actinobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,TPR_10
DYD2_k127_3532538_11	867903.ThesuDRAFT_00763	2.705e-41	163.0	COG0500@1|root,COG2226@2|Bacteria,1UZN6@1239|Firmicutes,24DUI@186801|Clostridia,3WDS2@538999|Clostridiales incertae sedis	186801|Clostridia	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
DYD2_k127_3532538_18	348780.NP_3700A	3.666e-16	92.0	arCOG06218@1|root,arCOG06218@2157|Archaea,2XVTI@28890|Euryarchaeota,23SSX@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
DYD2_k127_3532538_20	1054217.TALC_01224	3.022e-07	54.0	COG4023@1|root,arCOG02957@2157|Archaea	2157|Archaea	U	Involved in protein export. The function of the beta subunit is	secG	GO:0003674,GO:0005085,GO:0005086,GO:0005488,GO:0005515,GO:0008150,GO:0019899,GO:0051020,GO:0065007,GO:0065009,GO:0098772	-	-	-	-	-	-	-	-	-	-	Sec61_beta
DYD2_k127_3532538_19	566461.SSFG_01688	8.263e-08	65.0	COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria	201174|Actinobacteria	Q	polyketide synthase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
DYD2_k127_3532538_6	565033.GACE_1113	2.208e-70	261.0	COG1208@1|root,arCOG00668@2157|Archaea,2Y87G@28890|Euryarchaeota,2462R@183980|Archaeoglobi	183980|Archaeoglobi	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DYD2_k127_3532538_0	1121472.AQWN01000001_gene281	1.964e-189	609.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,2608Z@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
DYD2_k127_3532538_4	1173028.ANKO01000056_gene2161	7.924e-88	304.0	COG0745@1|root,COG2202@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG4251@2|Bacteria,1G2QC@1117|Cyanobacteria,1H7Q7@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_3532538_5	1278073.MYSTI_00873	3.707e-72	254.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2YUH5@29|Myxococcales	28221|Deltaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_3532538_1	797209.ZOD2009_22357	6.322e-125	415.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,23T8N@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
DYD2_k127_3532538_13	867903.ThesuDRAFT_01256	2.351e-40	157.0	COG0400@1|root,COG0400@2|Bacteria,1VZ3H@1239|Firmicutes	1239|Firmicutes	S	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3532538_17	1041930.Mtc_1058	5.254e-24	113.0	COG4083@1|root,arCOG04471@2157|Archaea,2XTQZ@28890|Euryarchaeota,2N9VN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
DYD2_k127_3532538_2	247490.KSU1_B0642	9.717e-121	408.0	COG0618@1|root,COG1226@1|root,COG0618@2|Bacteria,COG1226@2|Bacteria,2IXHC@203682|Planctomycetes	203682|Planctomycetes	P	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
DYD2_k127_3532538_24	1197130.BAFM01000015_gene2519	0.0004634	50.0	COG2133@1|root,arCOG11135@1|root,arCOG02796@2157|Archaea,arCOG11135@2157|Archaea,2XT1Q@28890|Euryarchaeota,23SKI@183963|Halobacteria	183963|Halobacteria	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,GSDH
DYD2_k127_3532538_14	387631.Asulf_00694	2.844e-40	154.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,246BC@183980|Archaeoglobi	183980|Archaeoglobi	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
DYD2_k127_3532538_12	755732.Fluta_2611	9.147e-41	161.0	COG0861@1|root,COG0861@2|Bacteria,4PJEK@976|Bacteroidetes,1IGED@117743|Flavobacteriia,2PC2T@246874|Cryomorphaceae	976|Bacteroidetes	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
DYD2_k127_3532538_21	926550.CLDAP_22130	5.201e-07	52.0	COG1051@1|root,COG1051@2|Bacteria,2G7HA@200795|Chloroflexi	200795|Chloroflexi	F	PFAM NUDIX hydrolase	mutX	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
DYD2_k127_3532538_9	460265.Mnod_0483	9.538e-49	196.0	2DB86@1|root,2Z7QD@2|Bacteria,1MX4S@1224|Proteobacteria,2TTA6@28211|Alphaproteobacteria,1JSGN@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
DYD2_k127_3532538_7	266834.SM_b20081	1.975e-66	233.0	COG2129@1|root,COG2129@2|Bacteria,1MVNK@1224|Proteobacteria,2U1YV@28211|Alphaproteobacteria,4BAGV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
DYD2_k127_3532538_22	1094980.Mpsy_3092	9.981e-06	56.0	COG0640@1|root,COG1719@1|root,arCOG01679@2157|Archaea,arCOG01688@2157|Archaea,2XY7Q@28890|Euryarchaeota,2N9Q7@224756|Methanomicrobia	224756|Methanomicrobia	K	V4R	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	HTH_5,V4R
DYD2_k127_3549224_13	1156935.QWE_15162	4.433e-18	92.0	COG0388@1|root,COG0388@2|Bacteria,1RA15@1224|Proteobacteria,2U1MJ@28211|Alphaproteobacteria,4B72M@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
DYD2_k127_3549224_1	518766.Rmar_2386	4.65e-129	433.0	COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes	976|Bacteroidetes	E	asparagine synthase (Glutamine-hydrolyzing	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
DYD2_k127_3549224_16	1123024.AUII01000026_gene2584	3.216e-06	60.0	COG0398@1|root,COG0398@2|Bacteria,2GN68@201174|Actinobacteria,4E6V6@85010|Pseudonocardiales	201174|Actinobacteria	S	SNARE associated Golgi protein	ydjZ	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DYD2_k127_3549224_4	1121012.AUKX01000022_gene2458	6.709e-83	284.0	COG2159@1|root,COG2159@2|Bacteria,4NJP9@976|Bacteroidetes,1HXKV@117743|Flavobacteriia,23FXD@178469|Arenibacter	976|Bacteroidetes	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
DYD2_k127_3549224_11	1382305.AZUC01000019_gene100	2.462e-45	182.0	COG0388@1|root,COG3153@1|root,COG0388@2|Bacteria,COG3153@2|Bacteria,1TQAZ@1239|Firmicutes,4HCQW@91061|Bacilli,26DCP@186818|Planococcaceae	91061|Bacilli	S	Carbon-nitrogen hydrolase	yhcX	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
DYD2_k127_3549224_9	1090318.ATTI01000001_gene938	3.937e-47	188.0	COG2270@1|root,COG2270@2|Bacteria,1QWEU@1224|Proteobacteria,2U333@28211|Alphaproteobacteria,2K8VZ@204457|Sphingomonadales	204457|Sphingomonadales	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_3549224_7	443906.CMM_2566	3.922e-54	218.0	COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,4FMUU@85023|Microbacteriaceae	201174|Actinobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
DYD2_k127_3549224_3	529709.PYCH_16980	6.965e-93	314.0	COG1703@1|root,arCOG01226@2157|Archaea,2XUHG@28890|Euryarchaeota,242YC@183968|Thermococci	183968|Thermococci	E	GTPase activity	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
DYD2_k127_3549224_15	387631.Asulf_00149	8.494e-08	65.0	arCOG10388@1|root,arCOG10388@2157|Archaea,2Y57I@28890|Euryarchaeota,247FR@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3549224_0	351160.RCIX1540	2.94e-262	829.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
DYD2_k127_3549224_14	1041930.Mtc_0701	1.049e-08	63.0	COG1813@1|root,arCOG01863@2157|Archaea	2157|Archaea	K	transcription factor, homolog of eukaryotic MBF1	-	-	2.1.1.72	ko:K00571,ko:K03627,ko:K07332	-	-	-	-	ko00000,ko01000,ko02035,ko02044,ko02048	-	-	-	HTH_3
DYD2_k127_3549224_8	1094980.Mpsy_2090	1.121e-49	196.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
DYD2_k127_3549224_17	1146883.BLASA_1244	5.465e-05	50.0	COG0640@1|root,COG0640@2|Bacteria,2IKUI@201174|Actinobacteria,4EW7P@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
DYD2_k127_3549224_12	56107.Cylst_2029	2.681e-38	166.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HKT0@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_3549224_6	399739.Pmen_3816	7.624e-55	220.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RZ3B@1236|Gammaproteobacteria,1YDT6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9
DYD2_k127_3549224_10	2074.JNYD01000046_gene7295	4.242e-47	197.0	COG0642@1|root,COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria,4DZ1T@85010|Pseudonocardiales	201174|Actinobacteria	KT	Serine phosphatase RsbU, regulator of sigma subunit	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
DYD2_k127_3549224_5	883078.HMPREF9695_00608	5.446e-77	295.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JR0R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MHYT,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
DYD2_k127_3549224_2	192952.MM_1134	1.635e-107	357.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2N966@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
DYD2_k127_3556271_2	298655.KI912266_gene2834	4.107e-72	250.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_3556271_4	1463920.JOGB01000031_gene6073	5.787e-46	192.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2ICGU@201174|Actinobacteria	201174|Actinobacteria	MV	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
DYD2_k127_3556271_5	304371.MCP_1917	1.152e-05	56.0	COG1241@1|root,arCOG02259@2157|Archaea,2Y283@28890|Euryarchaeota,2NA4Q@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA replication initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3556271_1	439481.Aboo_0123	8.152e-73	251.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,3F2PC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DYD2_k127_3556271_3	439481.Aboo_0123	4.481e-71	246.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,3F2PC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DYD2_k127_3556271_0	351160.RCIX2365	7.499e-270	844.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,2N99U@224756|Methanomicrobia	224756|Methanomicrobia	S	KH, type 1, domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
DYD2_k127_3556271_6	1324957.K933_12361	0.0001096	51.0	arCOG02416@1|root,arCOG02416@2157|Archaea,2Y01H@28890|Euryarchaeota,23XTV@183963|Halobacteria	183963|Halobacteria	N	protein conserved in archaea	pilA2	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
DYD2_k127_3556271_7	1168059.KB899087_gene2412	0.0004773	52.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2TS1X@28211|Alphaproteobacteria,3F1AC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	PilZ domain	celA	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glycos_transf_2,PilZ
DYD2_k127_3574361_1	1293048.CBMB010000001_gene34	2.174e-75	263.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,23SE1@183963|Halobacteria	183963|Halobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
DYD2_k127_3574361_0	694429.Pyrfu_0958	5.854e-119	397.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
DYD2_k127_362368_0	1177181.T9A_01949	3.983e-95	335.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XIKF@135619|Oceanospirillales	135619|Oceanospirillales	L	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DYD2_k127_362368_8	1448860.BBJO01000024_gene3134	4.5e-47	195.0	COG1637@1|root,arCOG01304@2157|Archaea,2XUC8@28890|Euryarchaeota,23S9C@183963|Halobacteria	183963|Halobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
DYD2_k127_362368_1	926550.CLDAP_25600	2.374e-89	318.0	COG3407@1|root,COG3407@2|Bacteria,2G5SQ@200795|Chloroflexi	200795|Chloroflexi	I	GHMP kinases N terminal domain	mvaD	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
DYD2_k127_362368_10	304371.MCP_2008	6.128e-36	152.0	COG0637@1|root,arCOG02293@2157|Archaea,2XTYU@28890|Euryarchaeota,2NAS6@224756|Methanomicrobia	224756|Methanomicrobia	S	Haloacid dehalogenase-like hydrolase	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
DYD2_k127_362368_4	886293.Sinac_6907	1.724e-60	222.0	COG5649@1|root,COG5649@2|Bacteria,2IYNG@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DYD2_k127_362368_6	68170.KL590482_gene519	5.968e-48	179.0	COG1403@1|root,COG1403@2|Bacteria,2GZ4J@201174|Actinobacteria,4EA18@85010|Pseudonocardiales	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
DYD2_k127_362368_2	886293.Sinac_6907	3.937e-76	259.0	COG5649@1|root,COG5649@2|Bacteria,2IYNG@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DYD2_k127_362368_17	311402.Avi_2837	0.0008417	51.0	29A35@1|root,2ZX4F@2|Bacteria,1R7KB@1224|Proteobacteria,2U264@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4917)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4917
DYD2_k127_362368_12	35754.JNYJ01000014_gene4765	2.816e-25	115.0	2DBV7@1|root,2ZB9P@2|Bacteria,2IGRZ@201174|Actinobacteria,4DCM4@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
DYD2_k127_362368_11	485913.Krac_0284	1.925e-32	132.0	2DBV7@1|root,2ZB9P@2|Bacteria,2G97K@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
DYD2_k127_362368_15	1116369.KB890024_gene3802	4.556e-18	85.0	COG3224@1|root,COG3224@2|Bacteria,1NA3J@1224|Proteobacteria,2UHMK@28211|Alphaproteobacteria,43MBA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_362368_9	1320556.AVBP01000023_gene2265	2.929e-45	171.0	COG1309@1|root,COG1309@2|Bacteria,1RCFF@1224|Proteobacteria,2UB62@28211|Alphaproteobacteria,43JJV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Bacterial transcriptional repressor C-terminal	phlF	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
DYD2_k127_362368_3	1173026.Glo7428_4059	6.236e-71	258.0	COG0492@1|root,COG0492@2|Bacteria,1G082@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DYD2_k127_362368_5	1266925.JHVX01000001_gene2532	1.42e-50	187.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,2VNIB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
DYD2_k127_362368_16	478741.JAFS01000001_gene1400	0.0001484	47.0	2E5PY@1|root,330EK@2|Bacteria,46WXS@74201|Verrucomicrobia,37GYN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_362368_13	1121945.ATXS01000001_gene2609	5.913e-24	108.0	COG1522@1|root,arCOG01580@2157|Archaea,2XWVQ@28890|Euryarchaeota,23VGP@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
DYD2_k127_362368_7	1122182.KB903825_gene784	8.394e-48	183.0	COG2755@1|root,COG2755@2|Bacteria,2GMDE@201174|Actinobacteria,4DAS4@85008|Micromonosporales	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
DYD2_k127_362368_14	1038858.AXBA01000018_gene1239	7.303e-21	98.0	COG2050@1|root,COG2050@2|Bacteria,1RDVV@1224|Proteobacteria,2UANF@28211|Alphaproteobacteria,3F1RZ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_3651134_6	1227484.C471_00855	7.615e-07	54.0	COG3369@1|root,arCOG01667@2157|Archaea,2Y111@28890|Euryarchaeota,23Y6W@183963|Halobacteria	183963|Halobacteria	S	Zinc finger CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
DYD2_k127_3651134_9	351160.RCIX398	0.0009022	49.0	COG3794@1|root,arCOG02926@2157|Archaea,2Y7QT@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
DYD2_k127_3651134_5	913325.N799_09145	1.123e-07	62.0	COG2345@1|root,COG2345@2|Bacteria,1QEPJ@1224|Proteobacteria,1TBH7@1236|Gammaproteobacteria,1XAK7@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3651134_1	1236689.MMALV_16330	9.435e-129	427.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,3F2H0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
DYD2_k127_3651134_0	745776.DGo_CA0381	7.199e-140	462.0	COG2865@1|root,COG2865@2|Bacteria	2|Bacteria	-	-	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
DYD2_k127_3651134_3	1236689.MMALV_02120	1.549e-40	158.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,3F2Q0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
DYD2_k127_3651134_2	1459636.NTE_02159	2.225e-74	262.0	COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Formyl transferase	-	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT_6,Formyl_trans_N
DYD2_k127_3651134_8	1502724.FF80_02823	0.0001173	54.0	2DSXN@1|root,33HV3@2|Bacteria,1NI61@1224|Proteobacteria,2UW0C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
DYD2_k127_3651134_4	999541.bgla_2g28660	1.416e-11	74.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1K311@119060|Burkholderiaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DYD2_k127_3651134_7	314278.NB231_03085	3.196e-06	50.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1WYF0@135613|Chromatiales	135613|Chromatiales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
DYD2_k127_3669203_13	273116.14324969	1.466e-14	81.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,241WZ@183967|Thermoplasmata	183967|Thermoplasmata	K	C2C2 Zinc finger	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
DYD2_k127_3669203_18	73501.XP_006673968.1	4.66e-05	52.0	COG2453@1|root,KOG2283@2759|Eukaryota,38CHA@33154|Opisthokonta,3NYC6@4751|Fungi,3QNXJ@4890|Ascomycota,214FP@147550|Sordariomycetes,3TGF9@5125|Hypocreales	4751|Fungi	T	phosphoinositide 3-phosphate phosphatase	TEP1	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005770,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0007049,GO:0008150,GO:0008152,GO:0009272,GO:0009653,GO:0009987,GO:0010927,GO:0012505,GO:0016043,GO:0016311,GO:0016314,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030258,GO:0030435,GO:0030437,GO:0030476,GO:0031410,GO:0031505,GO:0031982,GO:0032153,GO:0032502,GO:0032505,GO:0032989,GO:0034293,GO:0034594,GO:0042244,GO:0042546,GO:0042578,GO:0043226,GO:0043227,GO:0043229,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0045229,GO:0046486,GO:0046488,GO:0046839,GO:0046856,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051321,GO:0051704,GO:0052866,GO:0070590,GO:0070591,GO:0070726,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071852,GO:0071940,GO:0097708,GO:1903046	3.1.3.16,3.1.3.48,3.1.3.67	ko:K01104,ko:K01110	ko00562,ko01521,ko04068,ko04070,ko04071,ko04115,ko04140,ko04150,ko04151,ko04212,ko04218,ko04510,ko04931,ko05161,ko05165,ko05200,ko05206,ko05213,ko05214,ko05215,ko05218,ko05222,ko05224,ko05225,ko05230,map00562,map01521,map04068,map04070,map04071,map04115,map04140,map04150,map04151,map04212,map04218,map04510,map04931,map05161,map05165,map05200,map05206,map05213,map05214,map05215,map05218,map05222,map05224,map05225,map05230	-	R03363,R04513	RC00078	ko00000,ko00001,ko01000,ko01009	-	-	-	DSPc
DYD2_k127_3669203_10	1227487.C474_20686	8.273e-19	94.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,23VGY@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
DYD2_k127_3669203_6	1385521.N803_02330	8.998e-31	129.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4FGBY@85021|Intrasporangiaceae	201174|Actinobacteria	J	Belongs to the SUA5 family	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
DYD2_k127_3669203_3	69014.TK1183	1.051e-77	270.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
DYD2_k127_3669203_12	439481.Aboo_0653	6.477e-15	77.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0B2@28890|Euryarchaeota,3F2ST@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
DYD2_k127_3669203_16	1457250.BBMO01000001_gene325	8.995e-09	64.0	arCOG11887@1|root,arCOG11887@2157|Archaea,2Y0PR@28890|Euryarchaeota,23XTJ@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3669203_14	358396.C445_14462	1.119e-13	80.0	COG1733@1|root,arCOG01057@2157|Archaea,2Y0R2@28890|Euryarchaeota,23XJ2@183963|Halobacteria	183963|Halobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
DYD2_k127_3669203_0	266117.Rxyl_1758	3.781e-114	381.0	COG1062@1|root,COG1062@2|Bacteria,2GKJC@201174|Actinobacteria,4CQWP@84995|Rubrobacteria	84995|Rubrobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.90	ko:K00055	ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220	M00537,M00538	R01763,R02611,R04304,R05282,R05347,R05348	RC00087,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
DYD2_k127_3669203_5	1266925.JHVX01000001_gene2532	5.596e-54	198.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,2VNIB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
DYD2_k127_3669203_17	479432.Sros_4510	2.391e-07	60.0	COG0657@1|root,COG0657@2|Bacteria,2GJYR@201174|Actinobacteria,4EMN3@85012|Streptosporangiales	201174|Actinobacteria	I	Carboxylesterase family	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
DYD2_k127_3669203_11	1206737.BAGF01000059_gene3923	5.703e-15	79.0	COG1733@1|root,COG1733@2|Bacteria,2IMRH@201174|Actinobacteria,4G298@85025|Nocardiaceae	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
DYD2_k127_3669203_4	368407.Memar_0167	2.561e-58	214.0	COG0053@1|root,arCOG01474@2157|Archaea,2XU96@28890|Euryarchaeota,2N9HJ@224756|Methanomicrobia	224756|Methanomicrobia	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
DYD2_k127_3669203_9	425104.Ssed_1929	1.792e-19	102.0	293ZC@1|root,2ZREC@2|Bacteria,1RDYU@1224|Proteobacteria,1SBJC@1236|Gammaproteobacteria,2QBUU@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3669203_8	225849.swp_2103	4.718e-27	115.0	293ZC@1|root,2ZREC@2|Bacteria,1RDYU@1224|Proteobacteria,1SBJC@1236|Gammaproteobacteria,2QBUU@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3669203_2	225849.swp_3188	2.312e-90	304.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RNIU@1236|Gammaproteobacteria,2QB1U@267890|Shewanellaceae	1236|Gammaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
DYD2_k127_3669203_1	292459.STH2009	3.397e-106	364.0	COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,248E0@186801|Clostridia	186801|Clostridia	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
DYD2_k127_3669203_7	797209.ZOD2009_06799	1.779e-27	123.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,23T3G@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
DYD2_k127_3669203_15	590998.Celf_0336	8.543e-12	77.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4F0VU@85016|Cellulomonadaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	fbpC	-	-	ko:K02052,ko:K02062	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	ABC_tran,TOBE_2
DYD2_k127_3671820_1	1250006.JHZZ01000001_gene1212	2.42e-29	134.0	COG1913@1|root,COG1913@2|Bacteria,4NJFJ@976|Bacteroidetes,1HZVI@117743|Flavobacteriia,3VX1S@52959|Polaribacter	976|Bacteroidetes	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3671820_4	1449353.JQMQ01000005_gene3502	0.0006046	45.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,2NF2N@228398|Streptacidiphilus	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	tcrX	GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0098771	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
DYD2_k127_3671820_2	497964.CfE428DRAFT_4644	4.26e-17	90.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DYD2_k127_3671820_3	1131814.JAFO01000001_gene4926	1.973e-07	57.0	COG0745@1|root,COG0745@2|Bacteria,1R5FR@1224|Proteobacteria,2TTEH@28211|Alphaproteobacteria,3EZIT@335928|Xanthobacteraceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	prrA	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
DYD2_k127_3671820_0	1120983.KB894575_gene540	6.397e-30	120.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,1JN4V@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_3677092_4	370438.PTH_1946	3.641e-43	182.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
DYD2_k127_3677092_1	797209.ZOD2009_07134	3.859e-48	194.0	COG0705@1|root,arCOG01768@2157|Archaea,2XTJH@28890|Euryarchaeota,23SS3@183963|Halobacteria	183963|Halobacteria	E	nucleic acid binding protein containing the AN1-type Zn-finger	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
DYD2_k127_3677092_5	398767.Glov_2495	5.691e-28	121.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,43UQ7@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
DYD2_k127_3677092_3	590998.Celf_3038	1.482e-43	178.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
DYD2_k127_3677092_7	1500893.JQNB01000001_gene1052	3.009e-05	56.0	COG0727@1|root,COG0727@2|Bacteria,1MYCF@1224|Proteobacteria,1RYAX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
DYD2_k127_3677092_2	945713.IALB_2285	6.02e-47	180.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
DYD2_k127_3677092_0	523850.TON_1355	3.114e-59	228.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
DYD2_k127_3677092_6	1047013.AQSP01000066_gene724	1.864e-06	56.0	2E5PY@1|root,330EK@2|Bacteria,2NS29@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3795401_13	1382306.JNIM01000001_gene268	5.628e-50	180.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_3795401_4	479434.Sthe_1549	9.292e-110	372.0	COG0136@1|root,COG0136@2|Bacteria,2G5T9@200795|Chloroflexi,27XNM@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aspartate-semialdehyde dehydrogenase family	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
DYD2_k127_3795401_2	477974.Daud_2209	1.603e-127	425.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,260YE@186807|Peptococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
DYD2_k127_3795401_14	69014.TK0876	3.511e-45	181.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,243H9@183968|Thermococci	183968|Thermococci	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
DYD2_k127_3795401_6	868131.MSWAN_2046	1.611e-87	301.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,23PHT@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the peptidase M48B family	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
DYD2_k127_3795401_15	439481.Aboo_1228	1.075e-44	169.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,3F2ME@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
DYD2_k127_3795401_22	693661.Arcve_0281	2.959e-26	116.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,246B1@183980|Archaeoglobi	183980|Archaeoglobi	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
DYD2_k127_3795401_19	1131266.ARWQ01000001_gene1344	1.358e-31	143.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
DYD2_k127_3795401_0	439481.Aboo_0791	4.229e-217	686.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,3F2HU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
DYD2_k127_3795401_16	192952.MM_1305	1.095e-43	169.0	COG0517@1|root,arCOG00600@2157|Archaea,2XYA3@28890|Euryarchaeota,2N9Q4@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DYD2_k127_3795401_27	673860.AciM339_0276	8.612e-16	91.0	arCOG13537@1|root,arCOG13537@2157|Archaea,2Y1U2@28890|Euryarchaeota,3F2T4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3795401_30	661478.OP10G_4650	2.588e-09	73.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,DUF4365,HEAT_2,NACHT,Trans_reg_C
DYD2_k127_3795401_12	316274.Haur_2819	1.323e-57	232.0	COG3266@1|root,COG3266@2|Bacteria,2G7UN@200795|Chloroflexi,377BD@32061|Chloroflexia	32061|Chloroflexia	K	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3795401_17	742738.HMPREF9460_03622	1.084e-40	169.0	COG0346@1|root,COG0346@2|Bacteria,1V6SC@1239|Firmicutes,24HPI@186801|Clostridia,2691Y@186813|unclassified Clostridiales	186801|Clostridia	E	Glyoxalase-like domain	mce	-	4.4.1.5,5.1.99.1	ko:K01759,ko:K05606	ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02530,R02765,R09979	RC00004,RC00740,RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
DYD2_k127_3795401_34	311424.DhcVS_969	2.646e-06	61.0	COG0826@1|root,COG0826@2|Bacteria,2GAVB@200795|Chloroflexi,34DF3@301297|Dehalococcoidia	301297|Dehalococcoidia	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3795401_32	268739.Nmlp_2409	6.164e-07	61.0	COG0029@1|root,arCOG00572@2157|Archaea,2Y854@28890|Euryarchaeota,23TSY@183963|Halobacteria	183963|Halobacteria	H	Fumarate reductase succinate dehydrogenase flavoprotein	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
DYD2_k127_3795401_35	203119.Cthe_1824	0.0002309	48.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TT49@1239|Firmicutes,24DUZ@186801|Clostridia,3WKCS@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
DYD2_k127_3795401_5	1382306.JNIM01000001_gene2826	1.887e-89	310.0	COG1304@1|root,COG1304@2|Bacteria,2G5RF@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
DYD2_k127_3795401_20	195522.BD01_0251	2.905e-28	128.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2433D@183968|Thermococci	183968|Thermococci	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
DYD2_k127_3795401_24	1198449.ACAM_0978	1.424e-23	107.0	COG4900@1|root,arCOG04217@2157|Archaea,2XQUZ@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3795401_7	521011.Mpal_0331	8.316e-87	301.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
DYD2_k127_3795401_28	1283299.AUKG01000005_gene65	1.745e-13	85.0	COG2706@1|root,COG2706@2|Bacteria,2HQSY@201174|Actinobacteria,4CSHH@84995|Rubrobacteria	84995|Rubrobacteria	G	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
DYD2_k127_3795401_9	1042877.GQS_03815	7.918e-66	242.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,243QQ@183968|Thermococci	183968|Thermococci	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
DYD2_k127_3795401_8	1118054.CAGW01000108_gene3643	8.79e-82	285.0	COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,4H9UM@91061|Bacilli,26SYT@186822|Paenibacillaceae	91061|Bacilli	L	Adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
DYD2_k127_3795401_26	33035.JPJF01000047_gene882	1.649e-18	90.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,3Y2DE@572511|Blautia	186801|Clostridia	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
DYD2_k127_3795401_3	1236689.MMALV_01630	2.31e-112	377.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,3F2EV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	PFAM Aminotransferase class I and II	aspC3	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_3795401_29	497965.Cyan7822_1606	1.74e-11	78.0	COG1404@1|root,COG2931@1|root,COG4932@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1G1I0@1117|Cyanobacteria,3KI0C@43988|Cyanothece	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,FG-GAP,HemolysinCabind,SdrD_B
DYD2_k127_3795401_31	765912.Thimo_1752	4.632e-08	68.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
DYD2_k127_3795401_33	324602.Caur_0720	2.491e-06	62.0	COG1572@1|root,COG1572@2|Bacteria,2GBJ4@200795|Chloroflexi,377QB@32061|Chloroflexia	32061|Chloroflexia	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
DYD2_k127_3795401_10	1041930.Mtc_0282	2.25e-62	226.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,2N98I@224756|Methanomicrobia	224756|Methanomicrobia	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
DYD2_k127_3795401_23	797210.Halxa_3393	1.61e-25	117.0	COG3685@1|root,arCOG11147@2157|Archaea,2XUVS@28890|Euryarchaeota,23UYB@183963|Halobacteria	183963|Halobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
DYD2_k127_3795401_21	1089550.ATTH01000001_gene889	3.782e-27	128.0	COG1216@1|root,COG1216@2|Bacteria,4PND5@976|Bacteroidetes,1FKBH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
DYD2_k127_3795401_25	1116369.KB890026_gene5423	2.054e-23	113.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1P5B8@1224|Proteobacteria,2UEQX@28211|Alphaproteobacteria,43P16@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,DUF87,Hydrolase_3
DYD2_k127_3795401_11	273063.STK_09740	2.573e-59	227.0	COG0438@1|root,arCOG01408@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
DYD2_k127_3795401_1	1382306.JNIM01000001_gene2463	1.449e-146	486.0	COG3387@1|root,COG3387@2|Bacteria,2G7S0@200795|Chloroflexi	200795|Chloroflexi	G	COGs COG3387 Glucoamylase and related glycosyl hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
DYD2_k127_3800340_4	224325.AF_1181	5.442e-59	216.0	COG1100@1|root,arCOG00354@2157|Archaea,2XT36@28890|Euryarchaeota,246VT@183980|Archaeoglobi	183980|Archaeoglobi	S	GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	MMR_HSR1
DYD2_k127_3800340_1	1054217.TALC_01077	2.414e-153	518.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,241J5@183967|Thermoplasmata	183967|Thermoplasmata	J	Anticodon binding domain	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
DYD2_k127_3800340_6	1392838.AWNM01000017_gene3570	8.807e-30	129.0	COG4319@1|root,COG4319@2|Bacteria,1NHKV@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
DYD2_k127_3800340_0	351160.LRC306	6.033e-157	513.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,2N9CR@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
DYD2_k127_3800340_3	1123368.AUIS01000005_gene474	3.639e-109	376.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1RMCP@1236|Gammaproteobacteria,2NBYR@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DYD2_k127_3800340_2	63737.Npun_F5215	1.224e-135	453.0	arCOG06613@1|root,2Z7VT@2|Bacteria,1GQD1@1117|Cyanobacteria,1HTQ2@1161|Nostocales	1117|Cyanobacteria	S	AIPR protein	-	-	-	-	-	-	-	-	-	-	-	-	AIPR
DYD2_k127_3800340_5	456442.Mboo_1383	1.854e-51	194.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2N994@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DYD2_k127_3800340_7	644282.Deba_1364	6.498e-17	91.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2WR93@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM nitrogen-fixing NifU domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
DYD2_k127_3821636_23	1463920.JOGB01000024_gene3698	0.0003975	53.0	COG0640@1|root,COG0640@2|Bacteria,2HA3W@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_3821636_20	1415780.JPOG01000001_gene1140	2.352e-12	81.0	2C75R@1|root,2ZCK5@2|Bacteria,1NMP7@1224|Proteobacteria,1SHMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
DYD2_k127_3821636_6	479434.Sthe_3439	1.938e-68	252.0	COG1028@1|root,COG1028@2|Bacteria,2G8II@200795|Chloroflexi,27XKN@189775|Thermomicrobia	200795|Chloroflexi	IQ	Dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DYD2_k127_3821636_11	1304874.JAFY01000002_gene596	1.016e-52	196.0	COG0179@1|root,COG0179@2|Bacteria,3TC1D@508458|Synergistetes	508458|Synergistetes	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
DYD2_k127_3821636_8	251221.35212614	9.246e-63	228.0	COG1606@1|root,COG1606@2|Bacteria,1G10N@1117|Cyanobacteria	1117|Cyanobacteria	S	of the PP-loop superfamily	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
DYD2_k127_3821636_5	304371.MCP_0344	1.511e-88	319.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
DYD2_k127_3821636_17	498848.TaqDRAFT_4279	2.133e-15	84.0	COG0636@1|root,COG0636@2|Bacteria,1WK69@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM ATP synthase subunit C	atpP	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
DYD2_k127_3821636_18	469382.Hbor_28590	3.464e-14	82.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,23V78@183963|Halobacteria	183963|Halobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
DYD2_k127_3821636_9	1041930.Mtc_1398	1.463e-62	228.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
DYD2_k127_3821636_16	1054217.TALC_00009	2.671e-19	103.0	COG1436@1|root,arCOG04102@2157|Archaea,2XXYI@28890|Euryarchaeota	28890|Euryarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
DYD2_k127_3821636_0	351160.RCIX2030	1.785e-274	855.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
DYD2_k127_3821636_1	867903.ThesuDRAFT_01394	1.808e-233	759.0	COG0243@1|root,COG0243@2|Bacteria,1VTS0@1239|Firmicutes,25E9G@186801|Clostridia	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narB	-	-	ko:K00372,ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530,M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
DYD2_k127_3821636_19	349124.Hhal_0241	5.946e-14	79.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1WY76@135613|Chromatiales	135613|Chromatiales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
DYD2_k127_3821636_4	1304878.AUGD01000007_gene5664	4.038e-94	316.0	COG0656@1|root,COG0656@2|Bacteria,1MUH2@1224|Proteobacteria,2TTC2@28211|Alphaproteobacteria,3JV6E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aldo/keto reductase family	MA20_17035	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DYD2_k127_3821636_22	926550.CLDAP_16140	2.236e-11	78.0	COG1215@1|root,COG1215@2|Bacteria,2G6E4@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3,Glycos_transf_2
DYD2_k127_3821636_14	326427.Cagg_2514	1.441e-22	114.0	COG0438@1|root,COG0438@2|Bacteria,2GACM@200795|Chloroflexi,375BK@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3821636_13	593117.TGAM_0901	2.083e-32	142.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,242SB@183968|Thermococci	183968|Thermococci	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3821636_15	1463857.JOFZ01000007_gene47	1.345e-20	106.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	glgA	-	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3821636_12	1200792.AKYF01000003_gene247	3.446e-45	171.0	COG4276@1|root,COG4276@2|Bacteria,1V57F@1239|Firmicutes,4HJWD@91061|Bacilli,26XFR@186822|Paenibacillaceae	91061|Bacilli	S	Cell division protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
DYD2_k127_3821636_2	368407.Memar_1605	1.065e-124	412.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,2NANE@224756|Methanomicrobia	224756|Methanomicrobia	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
DYD2_k127_3821636_3	1220534.B655_1723	1.694e-105	365.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
DYD2_k127_3821636_10	368408.Tpen_0895	1.976e-58	223.0	COG0110@1|root,arCOG01848@2157|Archaea,2XQEI@28889|Crenarchaeota	28889|Crenarchaeota	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
DYD2_k127_3821636_7	224719.Abm4_0457	2.567e-63	231.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,23NSJ@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Oxidoreductase	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
DYD2_k127_3821636_21	414996.IL38_03885	3.045e-12	80.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,407GH@622450|Actinopolysporales	201174|Actinobacteria	M	Glycosyl transferases group 1	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_3839094_27	591158.SSMG_03494	4.386e-28	128.0	COG2244@1|root,COG2244@2|Bacteria,2GMYJ@201174|Actinobacteria	201174|Actinobacteria	G	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3
DYD2_k127_3839094_2	765913.ThidrDRAFT_0789	1.264e-123	417.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,1WW49@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
DYD2_k127_3839094_24	1123258.AQXZ01000010_gene3735	2.762e-37	152.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	rgpE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.4.1.166,2.7.8.14,2.7.8.47	ko:K00745,ko:K12988,ko:K18704	-	-	R11614,R11621	-	ko00000,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2,Methyltransf_11,Methyltransf_12
DYD2_k127_3839094_19	227377.CBU_1838	3.653e-60	228.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1JDEJ@118969|Legionellales	118969|Legionellales	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rmlC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
DYD2_k127_3839094_6	351160.RCIX200	5.62e-113	379.0	COG1088@1|root,arCOG01371@2157|Archaea,2XUZX@28890|Euryarchaeota,2N94H@224756|Methanomicrobia	224756|Methanomicrobia	M	Male sterility protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
DYD2_k127_3839094_18	693661.Arcve_0546	2.041e-64	231.0	COG1091@1|root,arCOG01367@2157|Archaea,2XVV7@28890|Euryarchaeota,245XF@183980|Archaeoglobi	183980|Archaeoglobi	M	TIGRFAM dTDP-4-dehydrorhamnose reductase	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
DYD2_k127_3839094_35	378806.STAUR_3115	5.555e-19	101.0	COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,42TVQ@68525|delta/epsilon subdivisions,2WQN4@28221|Deltaproteobacteria,2YV0V@29|Myxococcales	28221|Deltaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_3839094_11	195522.BD01_1478	9.844e-89	319.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,242ZG@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_3839094_28	543526.Htur_1204	7.557e-28	132.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
DYD2_k127_3839094_37	1229909.NSED_08885	9.961e-10	64.0	COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota	651137|Thaumarchaeota	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
DYD2_k127_3839094_4	1229909.NSED_08890	3.598e-115	391.0	COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
DYD2_k127_3839094_39	983917.RGE_21980	6.537e-06	52.0	COG3012@1|root,COG3012@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07039,ko:K09858	-	-	-	-	ko00000	-	-	-	PRiA4_ORF3,SEC-C
DYD2_k127_3839094_15	1041930.Mtc_0740	4.633e-78	272.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
DYD2_k127_3839094_16	751944.HALDL1_08455	2.386e-69	245.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,23T7A@183963|Halobacteria	183963|Halobacteria	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_3839094_31	1202768.JROF01000039_gene234	1.401e-23	115.0	COG0577@1|root,arCOG02312@2157|Archaea,2XSXF@28890|Euryarchaeota,23SHH@183963|Halobacteria	183963|Halobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DYD2_k127_3839094_33	1121378.KB899700_gene1933	1.783e-19	106.0	COG0577@1|root,COG0577@2|Bacteria,1WIT2@1297|Deinococcus-Thermus	2|Bacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
DYD2_k127_3839094_0	351160.RCIX231	6.265e-256	822.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
DYD2_k127_3839094_17	1121382.JQKG01000001_gene2366	6.822e-69	252.0	COG0473@1|root,COG0473@2|Bacteria,1WIIK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CE	Isocitrate isopropylmalate dehydrogenase	hicd	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0047046,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.87	ko:K05824	ko00300,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map01100,map01120,map01130,map01210,map01230	M00030,M00433	R01934,R01936,R04862	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
DYD2_k127_3839094_25	1382306.JNIM01000001_gene572	3.143e-36	156.0	COG0066@1|root,COG0066@2|Bacteria,2G6PB@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
DYD2_k127_3839094_7	1382306.JNIM01000001_gene571	3.524e-105	369.0	COG0065@1|root,COG0065@2|Bacteria,2G5IZ@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.114,4.2.1.33,4.2.1.35	ko:K01703,ko:K16792	ko00290,ko00300,ko00660,ko00680,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00432,M00433,M00535,M00608	R03444,R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R09720,R10170,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
DYD2_k127_3839094_12	272844.PAB0286	4.03e-87	301.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,243R2@183968|Thermococci	183968|Thermococci	E	homocitrate synthase activity	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
DYD2_k127_3839094_1	1449343.JQLQ01000002_gene582	2.009e-197	640.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,4HAI0@91061|Bacilli,27FVE@186828|Carnobacteriaceae	91061|Bacilli	P	Heavy-metal-associated domain	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
DYD2_k127_3839094_38	401526.TcarDRAFT_0722	3.088e-07	63.0	COG2608@1|root,COG2608@2|Bacteria,1VK5F@1239|Firmicutes,4H676@909932|Negativicutes	909932|Negativicutes	C	Heavy metal-associated domain protein	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
DYD2_k127_3839094_30	797299.HALLA_08955	4.553e-25	111.0	COG4329@1|root,arCOG10734@2157|Archaea,2XX7M@28890|Euryarchaeota,23VSY@183963|Halobacteria	183963|Halobacteria	S	Predicted membrane protein (DUF2243)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2243
DYD2_k127_3839094_10	1463881.KL591023_gene3613	3.538e-91	322.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter, ATP-binding protein	glnQ	-	3.6.3.21	ko:K02028,ko:K17076	ko02010,map02010	M00236,M00589	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.20	-	-	ABC_tran
DYD2_k127_3839094_20	1280692.AUJL01000013_gene3263	1.743e-52	199.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,36F1P@31979|Clostridiaceae	186801|Clostridia	P	ABC transporter	artQ	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
DYD2_k127_3839094_23	688269.Theth_1132	5.667e-39	160.0	COG0834@1|root,COG0834@2|Bacteria,2GBWS@200918|Thermotogae	200918|Thermotogae	ET	PFAM extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
DYD2_k127_3839094_34	1040989.AWZU01000032_gene3397	3.13e-19	97.0	COG0451@1|root,COG0451@2|Bacteria,1PRZV@1224|Proteobacteria,2V479@28211|Alphaproteobacteria,3JVV0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DYD2_k127_3839094_29	357808.RoseRS_2960	4.047e-27	117.0	COG0251@1|root,COG0251@2|Bacteria,2G6XT@200795|Chloroflexi,375RE@32061|Chloroflexia	32061|Chloroflexia	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
DYD2_k127_3839094_36	593750.Metfor_0719	8.855e-17	93.0	COG0569@1|root,COG3263@1|root,arCOG01957@2157|Archaea,arCOG01962@2157|Archaea,2Y871@28890|Euryarchaeota	28890|Euryarchaeota	P	COG0569 K transport systems NAD-binding component	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	TrkA_C,TrkA_N
DYD2_k127_3839094_22	751944.HALDL1_08315	1.778e-39	169.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota,23TAG@183963|Halobacteria	183963|Halobacteria	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
DYD2_k127_3839094_3	525904.Tter_1226	2.607e-117	391.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
DYD2_k127_3839094_9	243231.GSU3095	5.043e-98	329.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,43SZZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
DYD2_k127_3839094_21	1236689.MMALV_04900	1.692e-51	189.0	COG0139@1|root,COG0140@1|root,arCOG02676@2157|Archaea,arCOG02677@2157|Archaea,2XX3X@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
DYD2_k127_3839094_8	304371.MCP_0435	1.642e-98	346.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,2N94D@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
DYD2_k127_3839094_5	192952.MM_1047	2.672e-113	378.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,2N946@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
DYD2_k127_3839094_26	693661.Arcve_0149	1.075e-28	123.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_3839094_13	485913.Krac_8783	2.229e-85	306.0	COG0404@1|root,COG0404@2|Bacteria,2G5VA@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
DYD2_k127_3839094_14	1121430.JMLG01000036_gene167	3.12e-83	301.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,260C1@186807|Peptococcaceae	186801|Clostridia	C	Acyl-CoA dehydrogenase, N-terminal	-	-	1.3.8.1	ko:K00248,ko:K18244	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_3839094_32	1380394.JADL01000001_gene2539	5.457e-23	109.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2TSGP@28211|Alphaproteobacteria,2JR05@204441|Rhodospirillales	204441|Rhodospirillales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
DYD2_k127_385637_2	760568.Desku_3092	8.771e-181	634.0	COG2132@1|root,COG2132@2|Bacteria,1URD7@1239|Firmicutes,249RP@186801|Clostridia	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_3
DYD2_k127_385637_3	439481.Aboo_1381	3.13e-149	497.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,3F2HY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DYD2_k127_385637_10	439481.Aboo_1381	5.738e-69	253.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,3F2HY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
DYD2_k127_385637_17	439481.Aboo_1382	2.207e-47	183.0	COG1354@1|root,arCOG02610@2157|Archaea,2XZHK@28890|Euryarchaeota,3F2QG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
DYD2_k127_385637_21	673860.AciM339_1412	1.124e-31	132.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,3F2S6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	TIGRFAM segregation and condensation protein B	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
DYD2_k127_385637_16	439481.Aboo_0697	1.401e-47	181.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,3F2PP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Carbon-nitrogen hydrolase	-	-	3.5.1.100	ko:K18540	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
DYD2_k127_385637_12	391623.TERMP_01129	1.016e-58	215.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,242TE@183968|Thermococci	183968|Thermococci	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
DYD2_k127_385637_13	502025.Hoch_5296	2.343e-58	212.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DYD2_k127_385637_1	192952.MM_1096	1.941e-195	623.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
DYD2_k127_385637_24	673860.AciM339_1385	2.096e-27	118.0	COG0071@1|root,arCOG01833@2157|Archaea,2XY1D@28890|Euryarchaeota,3F2SN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Belongs to the small heat shock protein (HSP20) family	hsp20b	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DYD2_k127_385637_6	439481.Aboo_0426	5.584e-108	366.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,3F2HI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	PFAM Aminotransferase class I and II	aspC2	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
DYD2_k127_385637_8	368408.Tpen_0773	1.09e-82	291.0	COG0126@1|root,arCOG00496@2157|Archaea,2XPWD@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
DYD2_k127_385637_20	439481.Aboo_0638	6.94e-35	153.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,3F2MP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	SIS domain	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
DYD2_k127_385637_4	1094980.Mpsy_0886	1.237e-146	480.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
DYD2_k127_385637_9	529709.PYCH_02650	6.175e-72	262.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2435A@183968|Thermococci	183968|Thermococci	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
DYD2_k127_385637_25	81824.XP_001744135.1	1.818e-24	122.0	COG1413@1|root,KOG0567@2759|Eukaryota,38FQT@33154|Opisthokonta	33154|Opisthokonta	C	Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor	LIA1	GO:0000226,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006417,GO:0006464,GO:0006807,GO:0006996,GO:0007010,GO:0007017,GO:0008150,GO:0008152,GO:0008283,GO:0008612,GO:0009058,GO:0009268,GO:0009628,GO:0009889,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010467,GO:0010468,GO:0010506,GO:0010508,GO:0010556,GO:0010608,GO:0012505,GO:0016020,GO:0016043,GO:0016491,GO:0016705,GO:0018193,GO:0018205,GO:0019135,GO:0019222,GO:0019538,GO:0030447,GO:0031323,GO:0031325,GO:0031326,GO:0031329,GO:0031331,GO:0031984,GO:0032268,GO:0034248,GO:0036176,GO:0036177,GO:0036178,GO:0036211,GO:0040007,GO:0042175,GO:0042710,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044010,GO:0044011,GO:0044182,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044764,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051604,GO:0051703,GO:0051704,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090605,GO:0090609,GO:0098827,GO:1901564,GO:2000112,GO:2000765	1.14.99.29	ko:K06072,ko:K08187	ko04919,ko04974,map04919,map04974	-	-	-	ko00000,ko00001,ko01000,ko02000	2.A.1.13	-	-	HEAT_2,HEAT_PBS
DYD2_k127_385637_7	644966.Tmar_0462	9.695e-88	313.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3WDH0@538999|Clostridiales incertae sedis	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
DYD2_k127_385637_15	1288079.AUKN01000007_gene1982	1.276e-50	203.0	COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria	201174|Actinobacteria	L	helicase	helZ2	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
DYD2_k127_385637_0	1382306.JNIM01000001_gene441	1.358e-224	708.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
DYD2_k127_385637_11	304371.MCP_1332	1.682e-61	226.0	COG2358@1|root,arCOG01801@2157|Archaea,2XTR3@28890|Euryarchaeota	28890|Euryarchaeota	S	TRAP transporter solute receptor, TAXI family	imp	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
DYD2_k127_385637_5	304371.MCP_1334	2.06e-146	488.0	COG4666@1|root,arCOG01906@2157|Archaea,2XTB3@28890|Euryarchaeota	28890|Euryarchaeota	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
DYD2_k127_385637_19	318586.Pden_4195	1.542e-36	148.0	COG0778@1|root,COG0778@2|Bacteria,1PUI1@1224|Proteobacteria,2U13C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
DYD2_k127_385637_18	1223523.H340_11750	2.833e-43	183.0	COG1944@1|root,COG1944@2|Bacteria,2GKBS@201174|Actinobacteria	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
DYD2_k127_385637_26	105425.BBPL01000028_gene4102	9.781e-13	79.0	COG0476@1|root,COG0476@2|Bacteria,2GMJI@201174|Actinobacteria,2NGZS@228398|Streptacidiphilus	201174|Actinobacteria	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
DYD2_k127_385637_27	880072.Desac_2629	1.409e-11	78.0	COG0638@1|root,COG0638@2|Bacteria	2|Bacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
DYD2_k127_385637_29	521096.Tpau_2394	8.854e-10	70.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01990,ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
DYD2_k127_385637_14	926569.ANT_02350	5.842e-56	209.0	COG1131@1|root,COG1131@2|Bacteria,2G5RD@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DYD2_k127_385637_23	2074.JNYD01000001_gene6087	2.461e-29	136.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4DZ0E@85010|Pseudonocardiales	201174|Actinobacteria	GT	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
DYD2_k127_385637_30	1120792.JAFV01000001_gene1006	3.199e-08	62.0	COG3070@1|root,COG3070@2|Bacteria,1N8X8@1224|Proteobacteria,2UFNC@28211|Alphaproteobacteria,36YW0@31993|Methylocystaceae	28211|Alphaproteobacteria	K	TfoX N-terminal domain	MA20_30690	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
DYD2_k127_385637_22	521045.Kole_1745	7.692e-30	132.0	COG1047@1|root,COG1047@2|Bacteria,2GD8F@200918|Thermotogae	200918|Thermotogae	G	peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
DYD2_k127_385637_31	710111.FraQA3DRAFT_2590	6.309e-06	60.0	COG1595@1|root,COG3291@1|root,COG1595@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
DYD2_k127_385637_28	1396141.BATP01000003_gene4895	2.146e-11	64.0	COG2010@1|root,COG2133@1|root,COG3291@1|root,COG3474@1|root,COG3828@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3474@2|Bacteria,COG3828@2|Bacteria,46U71@74201|Verrucomicrobia,2IVDV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CG	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,DUF1080,HEAT_2,Laminin_G_3
DYD2_k127_3866286_0	1198449.ACAM_0020	5.441e-94	322.0	COG1845@1|root,arCOG04650@2157|Archaea	2157|Archaea	C	Heme copper-type cytochrome quinol	-	-	1.9.3.1,2.7.11.1	ko:K02276,ko:K12132,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000,ko01001	3.D.4.4,3.D.4.6	-	-	COX1,COX3
DYD2_k127_3866286_4	1230457.C476_07608	2.26e-26	120.0	COG1622@1|root,arCOG01235@2157|Archaea,2XURX@28890|Euryarchaeota,23S69@183963|Halobacteria	183963|Halobacteria	C	COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2	coxB4	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
DYD2_k127_3866286_3	164757.Mjls_3302	4.619e-33	139.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,233AV@1762|Mycobacteriaceae	201174|Actinobacteria	C	cytochrome c oxidase, subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
DYD2_k127_3866286_2	673860.AciM339_1009	3.129e-45	177.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,3F2N8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
DYD2_k127_3866286_1	316274.Haur_0261	6.926e-54	200.0	COG4143@1|root,COG4143@2|Bacteria,2G615@200795|Chloroflexi,376Q5@32061|Chloroflexia	32061|Chloroflexia	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
DYD2_k127_3905537_3	1254432.SCE1572_48810	5.839e-43	177.0	COG1520@1|root,COG1520@2|Bacteria,1QAB1@1224|Proteobacteria,434Y4@68525|delta/epsilon subdivisions,2X92T@28221|Deltaproteobacteria,2Z1KW@29|Myxococcales	28221|Deltaproteobacteria	G	PQQ enzyme repeat	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	PQQ,PQQ_2
DYD2_k127_3905537_8	1101190.ARWB01000001_gene134	3.515e-06	57.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,3712S@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
DYD2_k127_3905537_1	316274.Haur_3782	2.232e-125	419.0	COG0520@1|root,COG0520@2|Bacteria,2G7N0@200795|Chloroflexi,377HP@32061|Chloroflexia	32061|Chloroflexia	H	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
DYD2_k127_3905537_0	1054217.TALC_00617	4.878e-165	543.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,241KS@183967|Thermoplasmata	183967|Thermoplasmata	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
DYD2_k127_3905537_6	589924.Ferp_0541	1.179e-11	76.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_3905537_2	671143.DAMO_0753	9.839e-59	222.0	COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria	2|Bacteria	O	Pup-ligase protein	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
DYD2_k127_3905537_9	1197130.BAFM01000019_gene2764	1.198e-05	55.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y0YC@28890|Euryarchaeota,23XZ6@183963|Halobacteria	183963|Halobacteria	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
DYD2_k127_3905537_5	1459636.NTE_00644	2.797e-15	85.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3905537_7	1278073.MYSTI_05938	3.033e-06	59.0	COG2304@1|root,COG2304@2|Bacteria,1R5EY@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3905537_4	1121335.Clst_1213	1.111e-38	158.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3WIY7@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
DYD2_k127_3953769_1	1123373.ATXI01000007_gene1675	6.452e-25	112.0	COG1254@1|root,COG1254@2|Bacteria,2GHZK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
DYD2_k127_3953769_0	1459636.NTE_03150	1.802e-33	137.0	COG0526@1|root,arCOG01972@2157|Archaea	2157|Archaea	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
DYD2_k127_3953769_2	1380393.JHVP01000011_gene3081	3.639e-18	95.0	2BYAG@1|root,2ZC13@2|Bacteria,2IGUZ@201174|Actinobacteria,4EW5H@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_3953769_3	981369.JQMJ01000004_gene713	5.669e-06	59.0	COG3405@1|root,COG4409@1|root,COG3405@2|Bacteria,COG4409@2|Bacteria,2ID1A@201174|Actinobacteria,2NGZY@228398|Streptacidiphilus	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4003393_3	415426.Hbut_0632	2.502e-59	213.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
DYD2_k127_4003393_6	1137268.AZXF01000004_gene2215	1.655e-10	74.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2GIV0@201174|Actinobacteria,4EM40@85012|Streptosporangiales	201174|Actinobacteria	KLT	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
DYD2_k127_4003393_0	292459.STH3193	7.789e-239	758.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
DYD2_k127_4003393_5	765420.OSCT_2410	1.005e-28	120.0	COG0614@1|root,COG0614@2|Bacteria,2G9KR@200795|Chloroflexi,377DT@32061|Chloroflexia	32061|Chloroflexia	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
DYD2_k127_4003393_4	1227487.C474_01781	2.026e-51	196.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTKZ@28890|Euryarchaeota,23TPK@183963|Halobacteria	183963|Halobacteria	E	Belongs to the arginase family	hutG	-	3.5.3.11,3.5.3.8	ko:K01479,ko:K01480	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045,M00133	R01157,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
DYD2_k127_4003393_2	304371.MCP_0824	4.134e-67	239.0	COG4912@1|root,arCOG05122@2157|Archaea,2Y8HF@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
DYD2_k127_4003393_1	1210908.HSB1_18790	3.475e-123	411.0	COG1228@1|root,arCOG00696@2157|Archaea,2XUHH@28890|Euryarchaeota,23U5Z@183963|Halobacteria	183963|Halobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
DYD2_k127_4003393_7	548477.HMPREF0294_0332	4.288e-06	58.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
DYD2_k127_40515_1	304371.MCP_0109	2.839e-89	310.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,2N9BT@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
DYD2_k127_40515_0	574087.Acear_0289	1.914e-124	423.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
DYD2_k127_40515_2	673860.AciM339_0553	4.147e-31	124.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,3F3G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
DYD2_k127_40515_3	1054217.TALC_00032	4.425e-11	67.0	arCOG15031@1|root,arCOG15031@2157|Archaea,2Y4G8@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4135833_4	647113.Metok_0826	1.559e-67	250.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,23Q5I@183939|Methanococci	183939|Methanococci	E	PFAM Homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
DYD2_k127_4135833_10	1094980.Mpsy_0819	3.601e-10	67.0	COG2061@1|root,arCOG04396@2157|Archaea,2XWMD@28890|Euryarchaeota,2N9PF@224756|Methanomicrobia	224756|Methanomicrobia	E	amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4135833_7	1206732.BAGD01000097_gene4156	9.795e-34	136.0	COG3832@1|root,COG3832@2|Bacteria,2IN0A@201174|Actinobacteria,4G2TT@85025|Nocardiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
DYD2_k127_4135833_0	593117.TGAM_1809	3.27e-115	383.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,243IN@183968|Thermococci	183968|Thermococci	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_4135833_5	1183377.Py04_1006	2.244e-36	152.0	COG0083@1|root,arCOG01027@2157|Archaea,2XUDU@28890|Euryarchaeota,243D9@183968|Thermococci	183968|Thermococci	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
DYD2_k127_4135833_9	224325.AF_1009	2.483e-10	70.0	COG1378@1|root,arCOG02037@2157|Archaea,2Y64U@28890|Euryarchaeota,2473Q@183980|Archaeoglobi	183980|Archaeoglobi	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_4135833_3	868131.MSWAN_0583	4.817e-75	278.0	COG1131@1|root,arCOG00194@2157|Archaea,2XWVA@28890|Euryarchaeota	28890|Euryarchaeota	E	SMART ATPase, AAA type, core	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_4135833_2	1220534.B655_1140	6.676e-79	288.0	COG0842@1|root,arCOG01463@2157|Archaea,2XWB7@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DYD2_k127_4135833_6	426716.JOAJ01000008_gene4877	6.019e-35	149.0	COG1506@1|root,COG1506@2|Bacteria,2HHBX@201174|Actinobacteria,4FX9H@85025|Nocardiaceae	201174|Actinobacteria	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
DYD2_k127_4135833_14	555793.WSK_0203	4.561e-05	55.0	293ZC@1|root,2ZREC@2|Bacteria,1RDYU@1224|Proteobacteria,2U7U4@28211|Alphaproteobacteria,2K7J3@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4135833_1	1120971.AUCA01000001_gene1659	3.504e-109	373.0	COG0477@1|root,COG0477@2|Bacteria,1TPHW@1239|Firmicutes,4H9YA@91061|Bacilli,279FM@186823|Alicyclobacillaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	yusP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_4135833_8	1122929.KB908234_gene4056	1.169e-12	75.0	COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,2U7ND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG1846 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	MarR
DYD2_k127_4135833_13	1042877.GQS_08245	6.894e-06	55.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	183968|Thermococci	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_4135833_11	523850.TON_0811	4.502e-08	62.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_4135833_12	1038858.AXBA01000060_gene3662	1.864e-06	56.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,1RIJ9@1224|Proteobacteria,2U9ZV@28211|Alphaproteobacteria,3F087@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
DYD2_k127_4163679_0	215803.DB30_7881	7.064e-74	259.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2YTWD@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
DYD2_k127_4163679_1	1123322.KB904691_gene4435	1.414e-39	166.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_4163679_4	290397.Adeh_1821	1.237e-05	55.0	COG0321@1|root,COG1051@1|root,COG0321@2|Bacteria,COG1051@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WNRX@28221|Deltaproteobacteria,2Z30D@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
DYD2_k127_4163679_3	444157.Tneu_1473	6.706e-23	103.0	COG1324@1|root,arCOG04231@2157|Archaea,2XR6Y@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
DYD2_k127_4163679_2	797304.Natgr_1517	1.479e-26	110.0	COG1902@1|root,arCOG00615@2157|Archaea,2XV80@28890|Euryarchaeota,23T1G@183963|Halobacteria	183963|Halobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	yqjM2	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
DYD2_k127_4174527_0	234267.Acid_3077	0.0	1141.0	COG0304@1|root,COG3321@1|root,COG4221@1|root,COG0304@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria,3Y347@57723|Acidobacteria	57723|Acidobacteria	Q	Acyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
DYD2_k127_4174527_2	929556.Solca_0558	0.0005556	51.0	COG0517@1|root,COG0517@2|Bacteria,4NF8G@976|Bacteroidetes,1IRUD@117747|Sphingobacteriia	976|Bacteroidetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DYD2_k127_4174527_1	1306406.ASHX01000002_gene4533	1.012e-27	129.0	COG3866@1|root,COG3866@2|Bacteria,2I7X3@201174|Actinobacteria	201174|Actinobacteria	G	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_3,RicinB_lectin_2
DYD2_k127_4248034_16	1535422.ND16A_2329	0.0002006	48.0	2FG49@1|root,3480S@2|Bacteria,1P06Q@1224|Proteobacteria,1SRZT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
DYD2_k127_4248034_7	1173026.Glo7428_2348	1.06e-37	159.0	COG2251@1|root,COG2251@2|Bacteria,1G03D@1117|Cyanobacteria	1117|Cyanobacteria	S	RecB family	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas4,RNase_H_2
DYD2_k127_4248034_0	192952.MM_1486	2.155e-264	847.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
DYD2_k127_4248034_14	416348.Hlac_1609	1.036e-09	69.0	COG3413@1|root,arCOG02272@2157|Archaea,2Y7SJ@28890|Euryarchaeota,240WI@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
DYD2_k127_4248034_1	1123501.KB902277_gene960	4.968e-85	310.0	COG1352@1|root,COG2201@1|root,COG3920@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2TW1K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NT	methylesterase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HWE_HK,PAS_10,PAS_3,PAS_4,PAS_9
DYD2_k127_4248034_11	1123226.KB899316_gene1751	2.065e-14	84.0	COG5002@1|root,COG5002@2|Bacteria,1UII2@1239|Firmicutes,4HGW5@91061|Bacilli,26QEY@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
DYD2_k127_4248034_15	266117.Rxyl_1773	6.263e-08	64.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
DYD2_k127_4248034_9	682795.AciX8_3911	3.254e-21	102.0	COG0454@1|root,COG0454@2|Bacteria,3Y7TA@57723|Acidobacteria,2JN0X@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4248034_5	1236902.ANAS01000009_gene2437	9.201e-45	186.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4EIYA@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
DYD2_k127_4248034_2	1054217.TALC_00192	2.395e-69	243.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,241SN@183967|Thermoplasmata	183967|Thermoplasmata	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
DYD2_k127_4248034_12	1123024.AUII01000004_gene1496	1.788e-13	83.0	COG2102@1|root,COG2102@2|Bacteria,2INXV@201174|Actinobacteria,4EAZF@85010|Pseudonocardiales	201174|Actinobacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
DYD2_k127_4248034_10	351160.RCIX2292	9.302e-18	97.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,2N9ZZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	tfs	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
DYD2_k127_4248034_13	1210908.HSB1_15650	9.225e-11	67.0	arCOG09205@1|root,arCOG09205@2157|Archaea,2XVYM@28890|Euryarchaeota,23VNM@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function (DUF309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF309
DYD2_k127_4248034_8	439481.Aboo_1086	2.613e-37	146.0	COG1051@1|root,COG2005@1|root,arCOG00223@2157|Archaea,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,3F39U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
DYD2_k127_4248034_6	1054217.TALC_01541	7.695e-43	168.0	COG1772@1|root,arCOG04364@2157|Archaea,2XXJ6@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF531)	-	-	-	ko:K09725	-	-	-	-	ko00000	-	-	-	DUF531
DYD2_k127_4248034_3	593750.Metfor_0485	2.069e-55	204.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
DYD2_k127_4248034_4	1343739.PAP_01895	6.856e-54	196.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,243ZQ@183968|Thermococci	183968|Thermococci	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
DYD2_k127_4254624_4	673860.AciM339_0730	6.544e-32	130.0	COG4934@1|root,arCOG05978@1|root,arCOG03669@2157|Archaea,arCOG05978@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F38G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ,fn3
DYD2_k127_4254624_3	693661.Arcve_0931	2.006e-35	144.0	COG1058@1|root,arCOG00215@2157|Archaea,2XUAN@28890|Euryarchaeota,24649@183980|Archaeoglobi	183980|Archaeoglobi	S	Molybdenum cofactor synthesis domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
DYD2_k127_4254624_0	272844.PAB1276	1.213e-112	372.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,243N7@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_4254624_5	693661.Arcve_1149	4.63e-30	134.0	COG1721@1|root,arCOG02742@2157|Archaea,2Y7CK@28890|Euryarchaeota,246B6@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_4254624_2	1123508.JH636439_gene1283	7.496e-46	183.0	COG0783@1|root,COG0783@2|Bacteria,2IZJP@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
DYD2_k127_4254624_1	384616.Pisl_1675	1.353e-84	292.0	COG0270@1|root,arCOG04157@2157|Archaea,2XPTC@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
DYD2_k127_4254624_6	1089553.Tph_c10390	3.531e-21	102.0	COG1259@1|root,COG1259@2|Bacteria,1VCY4@1239|Firmicutes,24JJK@186801|Clostridia,42GWT@68295|Thermoanaerobacterales	186801|Clostridia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
DYD2_k127_4273623_8	694440.JOMF01000005_gene39	2.795e-21	94.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,2NA2D@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
DYD2_k127_4273623_3	565033.GACE_1605	7.078e-46	169.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2471N@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
DYD2_k127_4273623_6	323259.Mhun_2897	7.157e-27	124.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,2N9Q5@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
DYD2_k127_4273623_5	523845.AQXV01000053_gene704	7.727e-33	132.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,23R25@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
DYD2_k127_4273623_1	1236689.MMALV_13900	3.222e-138	460.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,3F2FF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
DYD2_k127_4273623_7	1026970.XP_008832476.1	1.574e-22	106.0	COG1896@1|root,KOG3197@2759|Eukaryota,38FZH@33154|Opisthokonta,3BIBA@33208|Metazoa,3D0PM@33213|Bilateria,48B1C@7711|Chordata,493FE@7742|Vertebrata,3JCGJ@40674|Mammalia,35N4C@314146|Euarchontoglires,4Q287@9989|Rodentia	33208|Metazoa	S	HD domain-containing protein 2	HDDC2	GO:0008150,GO:0030431,GO:0032501	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
DYD2_k127_4273623_2	572546.Arcpr_0680	4.438e-134	436.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,2462G@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ,ThiG
DYD2_k127_4273623_9	693661.Arcve_0074	1.631e-10	65.0	COG1694@1|root,arCOG01084@2157|Archaea,2Y3Y5@28890|Euryarchaeota,2476Y@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
DYD2_k127_4273623_4	635013.TherJR_0341	5.668e-41	175.0	COG0697@1|root,COG0697@2|Bacteria,1UZ6C@1239|Firmicutes,24GY3@186801|Clostridia,262MF@186807|Peptococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_4273623_0	525904.Tter_2035	1.96e-154	527.0	COG3387@1|root,COG3387@2|Bacteria,2NQPX@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 15	sga1	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0042301,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0071704,GO:0071944,GO:1901575	3.2.1.3	ko:K01178,ko:K07190	ko00500,ko01100,ko04020,ko04910,ko04922,map00500,map01100,map04020,map04910,map04922	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
DYD2_k127_4273623_10	1535287.JP74_08170	9.032e-09	68.0	COG2244@1|root,COG2244@2|Bacteria,1N49M@1224|Proteobacteria,2UEFC@28211|Alphaproteobacteria,3N7PI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
DYD2_k127_4280929_5	1048339.KB913029_gene2918	4.05e-48	184.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4280929_6	304371.MCP_0278	6.171e-19	87.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,2NA4S@224756|Methanomicrobia	224756|Methanomicrobia	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
DYD2_k127_4280929_1	339860.Msp_0370	9.264e-84	291.0	COG0436@1|root,arCOG04897@2157|Archaea,2XURI@28890|Euryarchaeota,23NXC@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
DYD2_k127_4280929_0	1236689.MMALV_06560	6.814e-219	696.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,3F2G2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	metal-binding domain in RNase L inhibitor, RLI	rli	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
DYD2_k127_4280929_4	1054217.TALC_00153	2.979e-52	199.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,241PC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_Crp_2
DYD2_k127_4280929_2	186497.PF1495	1.705e-80	284.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2433Q@183968|Thermococci	183968|Thermococci	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
DYD2_k127_4280929_3	694440.JOMF01000006_gene627	5.467e-68	240.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,2N950@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
DYD2_k127_4280929_7	237368.SCABRO_03518	7.571e-13	71.0	COG0457@1|root,COG0457@2|Bacteria	237368.SCABRO_03518|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4283421_5	679926.Mpet_0113	8.448e-12	66.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
DYD2_k127_4283421_6	27337.EGY19166	2.809e-06	60.0	KOG1217@1|root,KOG1217@2759|Eukaryota	2759|Eukaryota	O	calcium ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4283421_0	696281.Desru_2461	6.471e-172	570.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,260G6@186807|Peptococcaceae	186801|Clostridia	O	PFAM peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
DYD2_k127_4283421_7	1230457.C476_01037	1.987e-05	58.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
DYD2_k127_4283421_4	273116.14325442	1.028e-36	151.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,241TY@183967|Thermoplasmata	183967|Thermoplasmata	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
DYD2_k127_4283421_2	304371.MCP_1531	8.68e-58	218.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
DYD2_k127_4283421_3	1220534.B655_0127	1.772e-48	179.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23P1J@183925|Methanobacteria	183925|Methanobacteria	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
DYD2_k127_4283421_1	1121422.AUMW01000001_gene2319	5.721e-118	396.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,260WY@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
DYD2_k127_4331371_1	416591.Tlet_1950	8.858e-75	261.0	COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
DYD2_k127_4331371_2	926554.KI912636_gene3056	8.028e-49	195.0	COG2132@1|root,COG3794@1|root,COG2132@2|Bacteria,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K22348,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,DUF4396
DYD2_k127_4331371_4	593750.Metfor_1981	1.286e-18	86.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
DYD2_k127_4331371_0	1041930.Mtc_2082	1.459e-80	277.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
DYD2_k127_4331371_3	1459636.NTE_00013	1.239e-48	186.0	COG2085@1|root,arCOG00457@2157|Archaea	2157|Archaea	S	NADPH-dependent F420 reductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored,HTH_10
DYD2_k127_4331371_5	1071085.KK033114_gene931	3.597e-09	65.0	COG3398@1|root,arCOG02611@2157|Archaea,2XX30@28890|Euryarchaeota,23VMW@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_4350869_1	1006006.Mcup_0982	9.728e-25	111.0	COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea	2157|Archaea	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050662,GO:0051287,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	HTH_24,HTH_5,NAD_kinase,TrmB
DYD2_k127_4350869_0	1123386.AUIW01000002_gene1096	4.978e-250	782.0	COG0365@1|root,COG0365@2|Bacteria,1WI8W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
DYD2_k127_4368698_0	368407.Memar_0501	3.273e-22	113.0	COG1585@1|root,arCOG01912@2157|Archaea,2Y07X@28890|Euryarchaeota	28890|Euryarchaeota	O	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
DYD2_k127_4380697_12	718252.FP2_01160	0.0005261	52.0	COG1961@1|root,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,24ZVX@186801|Clostridia,3WNIQ@541000|Ruminococcaceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
DYD2_k127_4380697_3	1122951.ATUE01000006_gene1115	9.569e-108	361.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,1S7AD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DYD2_k127_4380697_4	1236689.MMALV_11840	1.27e-107	366.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,3F2I5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
DYD2_k127_4380697_11	868131.MSWAN_2282	3.869e-09	62.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
DYD2_k127_4380697_9	1041930.Mtc_1739	5.845e-40	156.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,2N9T0@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
DYD2_k127_4380697_7	351160.RCIX1354	2.064e-48	189.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
DYD2_k127_4380697_10	401526.TcarDRAFT_1050	5.106e-34	151.0	COG0672@1|root,COG0672@2|Bacteria,1TQIA@1239|Firmicutes,4H3MK@909932|Negativicutes	909932|Negativicutes	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
DYD2_k127_4380697_5	1144319.PMI16_00397	5.906e-66	246.0	COG1565@1|root,COG1565@2|Bacteria,1N06M@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4380697_1	1094980.Mpsy_0886	3.189e-114	386.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
DYD2_k127_4380697_8	338963.Pcar_1641	3.363e-44	177.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,43SEB@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
DYD2_k127_4380697_6	477974.Daud_1973	5.004e-64	228.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,261MR@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
DYD2_k127_4380697_2	477974.Daud_1972	1.221e-113	387.0	COG0026@1|root,COG0026@2|Bacteria,1TQCD@1239|Firmicutes,24ASU@186801|Clostridia,263XJ@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh_C,ATP-grasp
DYD2_k127_4380697_0	986075.CathTA2_2353	3.322e-131	429.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli	91061|Bacilli	C	Belongs to the citrate synthase family	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
DYD2_k127_4410522_4	1451189.CFAL_02090	0.0001943	55.0	2ATUN@1|root,31JDR@2|Bacteria,2HNM4@201174|Actinobacteria,22NQC@1653|Corynebacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
DYD2_k127_4410522_1	1054217.TALC_00029	2.646e-65	240.0	COG1676@1|root,arCOG01701@2157|Archaea,2Y6AD@28890|Euryarchaeota,241VY@183967|Thermoplasmata	183967|Thermoplasmata	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity)	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo
DYD2_k127_4410522_0	1242864.D187_001143	4.45e-91	310.0	COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,42Q5Q@68525|delta/epsilon subdivisions,2WNMS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,adh_short
DYD2_k127_4410522_2	338963.Pcar_2516	4.317e-38	153.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,42SPA@68525|delta/epsilon subdivisions,2WPPE@28221|Deltaproteobacteria,43VDT@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_4410522_3	471853.Bcav_2782	2.718e-09	72.0	COG1404@1|root,COG2911@1|root,COG4932@1|root,COG5492@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG4932@2|Bacteria,COG5492@2|Bacteria,2GYXK@201174|Actinobacteria	201174|Actinobacteria	M	Invasin, domain 3	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Invasin_D3
DYD2_k127_4420996_1	448385.sce1718	5.672e-25	123.0	COG1305@1|root,COG1305@2|Bacteria,1R0BY@1224|Proteobacteria,43DTA@68525|delta/epsilon subdivisions,2X8VQ@28221|Deltaproteobacteria,2Z0KI@29|Myxococcales	28221|Deltaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
DYD2_k127_4420996_0	673860.AciM339_0952	3.932e-44	172.0	COG1591@1|root,arCOG00919@2157|Archaea,2XY2Q@28890|Euryarchaeota,3F2NJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Archaeal holliday junction resolvase (hjc)	-	-	-	-	-	-	-	-	-	-	-	-	Hjc
DYD2_k127_4420996_2	795797.C497_07819	0.0002157	50.0	arCOG04590@1|root,arCOG04590@2157|Archaea,2XXFN@28890|Euryarchaeota,23VN8@183963|Halobacteria	183963|Halobacteria	S	membrane-bound metal-dependent	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
DYD2_k127_4420996_3	1379698.RBG1_1C00001G1271	0.0004985	49.0	COG1630@1|root,COG1630@2|Bacteria	2|Bacteria	S	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
DYD2_k127_4421063_1	192952.MM_3076	4.698e-179	586.0	COG0550@1|root,arCOG01527@2157|Archaea,arCOG06233@2157|Archaea,2XU6T@28890|Euryarchaeota,2N96B@224756|Methanomicrobia	224756|Methanomicrobia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
DYD2_k127_4421063_22	571166.KI421509_gene4310	2.328e-06	60.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_4421063_11	1206741.BAFX01000084_gene6270	3.262e-21	107.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4421063_3	439481.Aboo_0158	4.114e-87	308.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,3F2GM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
DYD2_k127_4421063_17	937777.Deipe_0409	4.458e-09	62.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726,ko:K13655	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3
DYD2_k127_4421063_7	640081.Dsui_3504	4.036e-78	290.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,2KVPB@206389|Rhodocyclales	206389|Rhodocyclales	P	Rhodanese Homology Domain	tst	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
DYD2_k127_4421063_0	351160.LRC303	3.579e-223	723.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
DYD2_k127_4421063_8	1089548.KI783301_gene1143	9.902e-59	220.0	COG2132@1|root,COG2132@2|Bacteria,1TQJK@1239|Firmicutes,4IRUW@91061|Bacilli	91061|Bacilli	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
DYD2_k127_4421063_21	1385519.N801_16915	6.412e-07	57.0	COG4891@1|root,COG4891@2|Bacteria,2ISCT@201174|Actinobacteria,4FJHC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
DYD2_k127_4421063_23	710696.Intca_3398	6.916e-06	54.0	COG3832@1|root,COG3832@2|Bacteria,2I61C@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
DYD2_k127_4421063_2	1429916.X566_05235	3.532e-104	369.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,3JQV1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
DYD2_k127_4421063_24	1121945.ATXS01000011_gene2855	7.514e-05	55.0	COG3398@1|root,arCOG02611@2157|Archaea,2XX30@28890|Euryarchaeota,23VMW@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_4421063_16	765698.Mesci_2018	2.134e-09	70.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,43MH7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_4421063_20	1007103.AFHW01000149_gene790	5.152e-07	61.0	COG5528@1|root,COG5528@2|Bacteria,1VW9Q@1239|Firmicutes,4HWSC@91061|Bacilli,26YQB@186822|Paenibacillaceae	91061|Bacilli	S	Predicted integral membrane protein (DUF2269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2269
DYD2_k127_4421063_10	68260.JOAY01000043_gene1256	1.785e-29	131.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria	201174|Actinobacteria	S	Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DYD2_k127_4421063_25	253839.SSNG_01934	0.0008231	51.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria	201174|Actinobacteria	Q	phytoene	crtI2	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
DYD2_k127_4421063_9	368407.Memar_1059	1.768e-48	187.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,2N9HA@224756|Methanomicrobia	224756|Methanomicrobia	Q	RNA methylase	trmL	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
DYD2_k127_4421063_18	926569.ANT_03650	4.59e-09	69.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
DYD2_k127_4421063_5	1094980.Mpsy_2010	4.879e-86	305.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2N9FP@224756|Methanomicrobia	224756|Methanomicrobia	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
DYD2_k127_4421063_6	1210884.HG799462_gene8049	2.692e-81	282.0	COG1131@1|root,COG1131@2|Bacteria,2IZ5V@203682|Planctomycetes	203682|Planctomycetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_4421063_19	575540.Isop_2112	1.224e-07	65.0	COG1277@1|root,COG1277@2|Bacteria,2J0ZV@203682|Planctomycetes	203682|Planctomycetes	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
DYD2_k127_4421063_4	575540.Isop_2113	7.629e-87	297.0	COG1131@1|root,COG1131@2|Bacteria,2IZF2@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_4421063_15	1894.JOER01000016_gene5542	7.736e-11	75.0	COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
DYD2_k127_4421063_14	66874.JOFS01000049_gene3200	7.323e-12	78.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_4421063_26	192952.MM_2446	0.0008397	52.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,2NB4N@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_4421063_12	452652.KSE_61170	1.623e-18	97.0	COG3861@1|root,COG3861@2|Bacteria,2II0U@201174|Actinobacteria,2M3VY@2063|Kitasatospora	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,PRC
DYD2_k127_4421063_13	1120948.KB903227_gene4835	3.326e-12	79.0	COG3861@1|root,COG3861@2|Bacteria,2II0U@201174|Actinobacteria,4E2J5@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,PRC
DYD2_k127_4466095_1	926561.KB900621_gene2824	9.917e-30	123.0	COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24J8R@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
DYD2_k127_4466095_0	1047013.AQSP01000037_gene1322	2.728e-91	318.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294,ko:K13868	ko04974,map04974	-	-	-	ko00000,ko00001,ko02000	2.A.3.2,2.A.3.8.15	-	-	AA_permease_2
DYD2_k127_4543510_10	1041930.Mtc_0663	7.382e-36	147.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4543510_15	1198449.ACAM_1183	2.066e-10	73.0	arCOG00372@1|root,arCOG00372@2157|Archaea	2157|Archaea	P	cobalamin transport	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4543510_3	1254432.SCE1572_33630	1.122e-93	320.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,43B63@68525|delta/epsilon subdivisions,2X6JM@28221|Deltaproteobacteria,2YYC8@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
DYD2_k127_4543510_6	1379698.RBG1_1C00001G1620	1.469e-59	220.0	COG2222@1|root,COG2222@2|Bacteria,2NQVV@2323|unclassified Bacteria	2|Bacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	pgi	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
DYD2_k127_4543510_13	887062.HGR_08944	2.456e-17	94.0	arCOG13010@1|root,33AIE@2|Bacteria,1NJAU@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4543510_12	351160.RCIX840	1.329e-33	138.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
DYD2_k127_4543510_18	42256.RradSPS_0608	2.294e-05	51.0	COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria,4CSXA@84995|Rubrobacteria	84995|Rubrobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
DYD2_k127_4543510_16	948106.AWZT01000002_gene6368	6.35e-07	57.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1KG4B@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_4543510_5	118168.MC7420_7600	6.11e-71	251.0	COG0664@1|root,COG0664@2|Bacteria,1GQ6E@1117|Cyanobacteria,1HAZ8@1150|Oscillatoriales	1117|Cyanobacteria	T	transport	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
DYD2_k127_4543510_2	523850.TON_0152	3.307e-133	449.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
DYD2_k127_4543510_19	861208.AGROH133_09420	6.739e-05	53.0	COG4190@1|root,COG4190@2|Bacteria,1Q3IN@1224|Proteobacteria,2V5T6@28211|Alphaproteobacteria,4BJR4@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4543510_17	1278073.MYSTI_06568	2.284e-06	59.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria,2YUWZ@29|Myxococcales	28221|Deltaproteobacteria	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
DYD2_k127_4543510_9	96561.Dole_0399	7.606e-38	156.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	1.14.19.9	ko:K14266	ko00404,ko01130,map00404,map01130	M00789,M00790	R09570	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	MDMPI_N,Trp_halogenase
DYD2_k127_4543510_4	1094980.Mpsy_1195	8.833e-76	267.0	COG1899@1|root,arCOG04142@2157|Archaea,2XUTF@28890|Euryarchaeota,2N9AF@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-1	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
DYD2_k127_4543510_8	439481.Aboo_0305	3.002e-39	156.0	COG1468@1|root,arCOG00786@2157|Archaea,2Y71A@28890|Euryarchaeota,3F34X@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	TIGRFAM CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PDDEXK_1
DYD2_k127_4543510_14	1227495.C487_07215	4.542e-17	93.0	COG0681@1|root,arCOG01739@2157|Archaea,2XU45@28890|Euryarchaeota,23U0G@183963|Halobacteria	183963|Halobacteria	U	COG0681 Signal peptidase I	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
DYD2_k127_4543510_0	673860.AciM339_1497	0.0	1069.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,3F2HV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
DYD2_k127_4543510_11	1122951.ATUE01000005_gene1709	1.593e-35	149.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,3NNG6@468|Moraxellaceae	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	ycdF	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
DYD2_k127_4543510_1	1340493.JNIF01000003_gene4184	3.605e-144	511.0	COG2373@1|root,COG2373@2|Bacteria,3Y439@57723|Acidobacteria	57723|Acidobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
DYD2_k127_4543510_7	84531.JMTZ01000018_gene3881	2.841e-43	171.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4543510_20	1415780.JPOG01000001_gene3063	7.543e-05	51.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_4557739_1	697281.Mahau_2245	5.777e-44	172.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,42FR5@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM 8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
DYD2_k127_4557739_0	1229205.BUPH_04525	1.01e-80	284.0	COG0491@1|root,COG0491@2|Bacteria,1NMU0@1224|Proteobacteria,2W825@28216|Betaproteobacteria,1K57H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13,Lactamase_B_5
DYD2_k127_4557739_5	1348663.KCH_64760	7.125e-05	55.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,2M0HM@2063|Kitasatospora	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
DYD2_k127_4557739_3	1227454.C446_15915	6.003e-06	59.0	COG3428@1|root,arCOG04619@2157|Archaea,2XWHU@28890|Euryarchaeota,23VDM@183963|Halobacteria	183963|Halobacteria	S	Membrane-flanked domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
DYD2_k127_4557739_4	351607.Acel_0399	6.003e-06	59.0	COG3402@1|root,COG3402@2|Bacteria,2I2JX@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
DYD2_k127_4557739_2	1449063.JMLS01000009_gene2329	2.661e-23	106.0	COG1670@1|root,COG1670@2|Bacteria,1V3BC@1239|Firmicutes,4HFVN@91061|Bacilli,274T5@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DYD2_k127_4557739_6	795797.C497_01800	0.0001482	51.0	COG4113@1|root,arCOG00727@2157|Archaea,2XZXX@28890|Euryarchaeota	28890|Euryarchaeota	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_4560237_5	1210046.B277_03890	2.041e-12	81.0	COG1305@1|root,COG1721@1|root,COG1305@2|Bacteria,COG1721@2|Bacteria,2HQBB@201174|Actinobacteria,4FE68@85021|Intrasporangiaceae	201174|Actinobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
DYD2_k127_4560237_0	246969.TAM4_1127	4.711e-98	345.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_4560237_2	1238425.J07HQW2_02999	9.157e-24	104.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,23W4Z@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4560237_3	765869.BDW_10440	3.365e-19	100.0	COG3729@1|root,COG3729@2|Bacteria,1NH1J@1224|Proteobacteria	1224|Proteobacteria	S	General stress protein	-	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	KGG
DYD2_k127_4560237_1	211165.AJLN01000152_gene6838	1.095e-55	212.0	COG1073@1|root,COG1073@2|Bacteria,1G4HS@1117|Cyanobacteria,1JKRS@1189|Stigonemataceae	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
DYD2_k127_4560237_6	1449357.JQLK01000001_gene1210	6.869e-08	65.0	COG1520@1|root,COG4447@1|root,COG1520@2|Bacteria,COG4447@2|Bacteria,1WJIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4560237_4	1227454.C446_09970	2.263e-16	87.0	COG1487@1|root,arCOG02219@2157|Archaea,2XZ1Z@28890|Euryarchaeota,23WY3@183963|Halobacteria	183963|Halobacteria	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
DYD2_k127_4560237_7	1455608.JDTH01000002_gene2021	7.426e-05	52.0	arCOG08146@1|root,arCOG08146@2157|Archaea,2XZG5@28890|Euryarchaeota,23X98@183963|Halobacteria	183963|Halobacteria	K	Pfam:DUF217	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
DYD2_k127_4568571_0	1227484.C471_08950	6.228e-160	519.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,23SU2@183963|Halobacteria	183963|Halobacteria	C	COG1012 NAD-dependent aldehyde dehydrogenases	aldY5	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DYD2_k127_4587342_0	589924.Ferp_0234	5.833e-55	209.0	COG1404@1|root,arCOG00702@2157|Archaea,2XSZR@28890|Euryarchaeota,2478R@183980|Archaeoglobi	28890|Euryarchaeota	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	3.4.21.62	ko:K01342,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
DYD2_k127_4587342_3	317619.ANKN01000222_gene1455	5.411e-05	55.0	COG2372@1|root,COG2372@2|Bacteria,1G65Y@1117|Cyanobacteria	1117|Cyanobacteria	S	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4587342_2	1313301.AUGC01000008_gene438	5.837e-38	154.0	COG0697@1|root,COG0697@2|Bacteria,4NGZ3@976|Bacteroidetes	976|Bacteroidetes	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_4587342_1	370438.PTH_0376	3.058e-40	161.0	COG4743@1|root,COG4743@2|Bacteria,1TSEB@1239|Firmicutes,24DEA@186801|Clostridia,2618T@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1616
DYD2_k127_4617726_5	1297742.A176_05992	2.379e-22	113.0	2DRAF@1|root,33AYA@2|Bacteria,1NGMJ@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3293)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3293
DYD2_k127_4617726_6	797114.C475_01611	1.422e-15	90.0	COG5276@1|root,arCOG02565@2157|Archaea,2XV6J@28890|Euryarchaeota,23SNQ@183963|Halobacteria	183963|Halobacteria	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_4617726_3	290397.Adeh_2388	2.15e-35	143.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2YVIU@29|Myxococcales	28221|Deltaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
DYD2_k127_4617726_4	1094980.Mpsy_1859	1.077e-24	116.0	COG0467@1|root,arCOG01175@2157|Archaea,2Y7UD@28890|Euryarchaeota,2NBDD@224756|Methanomicrobia	224756|Methanomicrobia	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DYD2_k127_4617726_0	679926.Mpet_1819	5.02e-166	558.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DYD2_k127_4617726_1	368407.Memar_2002	1.58e-50	192.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y7HY@28890|Euryarchaeota,2NBK4@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DYD2_k127_4617726_2	456442.Mboo_1903	6.369e-43	181.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAP1@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DYD2_k127_4617726_7	1239962.C943_03620	7.738e-08	67.0	COG4447@1|root,COG4447@2|Bacteria,4NRP7@976|Bacteroidetes	976|Bacteroidetes	UW	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
DYD2_k127_4626748_9	368408.Tpen_0359	1.724e-12	76.0	COG1400@1|root,arCOG01217@2157|Archaea,2XRIR@28889|Crenarchaeota	28889|Crenarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
DYD2_k127_4626748_3	673860.AciM339_1543	8.78e-39	148.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,3F2SE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein S8e	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
DYD2_k127_4626748_5	1054217.TALC_00178	2.501e-30	124.0	arCOG03678@1|root,arCOG03678@2157|Archaea,2XZ63@28890|Euryarchaeota,241VC@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4626748_10	572546.Arcpr_1099	4.97e-11	70.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,246CG@183980|Archaeoglobi	183980|Archaeoglobi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
DYD2_k127_4626748_0	194439.CT0976	2.291e-115	379.0	COG0524@1|root,COG0524@2|Bacteria,1FDJI@1090|Chlorobi	1090|Chlorobi	H	PFAM PfkB domain protein	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
DYD2_k127_4626748_7	1330700.JQNC01000003_gene1281	9.726e-27	118.0	COG0755@1|root,COG0755@2|Bacteria,1WISW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ABC-type transport system involved in cytochrome c biogenesis permease component	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
DYD2_k127_4626748_4	926569.ANT_19400	1.012e-36	149.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
DYD2_k127_4626748_6	1123388.AQWU01000041_gene462	5.626e-30	126.0	COG1131@1|root,COG1131@2|Bacteria,1WI8V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC-type multidrug transport system ATPase component	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
DYD2_k127_4626748_8	416348.Hlac_0132	2.381e-20	104.0	COG0671@1|root,arCOG03951@2157|Archaea,2XU0M@28890|Euryarchaeota,23UP8@183963|Halobacteria	183963|Halobacteria	I	COG0671 Membrane-associated phospholipid phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
DYD2_k127_4626748_2	1441930.Z042_21100	3.204e-62	225.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,1RMRX@1236|Gammaproteobacteria,401AZ@613|Serratia	1236|Gammaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	GO:0001882,GO:0001884,GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006217,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009972,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0036094,GO:0042454,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046092,GO:0046121,GO:0046125,GO:0046127,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	iECO103_1326.ECO103_2618	dCMP_cyt_deam_1,dCMP_cyt_deam_2
DYD2_k127_4626748_1	246969.TAM4_706	1.837e-67	245.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
DYD2_k127_4626748_11	1463887.KL590014_gene5093	9.53e-05	54.0	COG4409@1|root,COG4409@2|Bacteria,2ID1A@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4631271_0	368407.Memar_0787	1.083e-82	287.0	COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,2N9K8@224756|Methanomicrobia	224756|Methanomicrobia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
DYD2_k127_4631271_3	936136.ARRT01000002_gene373	2.609e-18	93.0	2EPV2@1|root,33HFI@2|Bacteria,1P4JW@1224|Proteobacteria,2UYBR@28211|Alphaproteobacteria,4BH9U@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4631271_2	368408.Tpen_1066	1.89e-22	109.0	COG1475@1|root,arCOG01875@2157|Archaea	2157|Archaea	K	PFAM ParB domain protein nuclease	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
DYD2_k127_4631271_4	368407.Memar_1917	1.541e-13	81.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
DYD2_k127_4631271_1	452637.Oter_3531	1.487e-25	109.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,46SGF@74201|Verrucomicrobia,3K78M@414999|Opitutae	414999|Opitutae	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
DYD2_k127_4635936_3	453591.Igni_0850	2.052e-26	117.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
DYD2_k127_4635936_4	1210908.HSB1_22710	6.155e-16	92.0	COG0671@1|root,arCOG03951@2157|Archaea,2XU0M@28890|Euryarchaeota,23UP8@183963|Halobacteria	183963|Halobacteria	I	COG0671 Membrane-associated phospholipid phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
DYD2_k127_4635936_1	351160.RCIX1175	1.11e-90	324.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,2N94Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
DYD2_k127_4635936_6	247490.KSU1_B0604	1.198e-08	66.0	2EABA@1|root,334FH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIG
DYD2_k127_4635936_0	351160.RCIX1437	8.866e-118	397.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N92Y@224756|Methanomicrobia	224756|Methanomicrobia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
DYD2_k127_4635936_2	309801.trd_A0786	8.105e-40	169.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZW@200795|Chloroflexi,27YUJ@189775|Thermomicrobia	189775|Thermomicrobia	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
DYD2_k127_4635936_5	673860.AciM339_0459	1.818e-10	70.0	COG2034@1|root,arCOG02717@2157|Archaea,2XZVB@28890|Euryarchaeota,3F3HD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF131	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
DYD2_k127_4635936_7	797302.Halru_2177	8.425e-08	63.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23V74@183963|Halobacteria	183963|Halobacteria	H	Phosphopantetheine adenylyltransferase	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
DYD2_k127_4638261_0	977880.RALTA_A2681	1.327e-146	510.0	COG0457@1|root,COG1409@1|root,COG0457@2|Bacteria,COG1409@2|Bacteria,1PFH9@1224|Proteobacteria,2W1YZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4638261_2	977880.RALTA_A2683	6.029e-59	235.0	COG1672@1|root,COG1672@2|Bacteria,1NB2E@1224|Proteobacteria	1224|Proteobacteria	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
DYD2_k127_4638261_1	1121468.AUBR01000026_gene2914	4.659e-82	284.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_4638261_3	665577.JH993790_gene4566	4.225e-34	148.0	COG3663@1|root,COG3663@2|Bacteria,2GNS5@201174|Actinobacteria	201174|Actinobacteria	L	DNA glycosylase	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
DYD2_k127_4638261_4	273075.Ta0407	6.707e-10	70.0	COG4741@1|root,arCOG05252@2157|Archaea,2XYG2@28890|Euryarchaeota	28890|Euryarchaeota	F	Endonuclease related to archaeal Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
DYD2_k127_4638261_5	797302.Halru_1910	2.072e-09	68.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_4664482_3	1047013.AQSP01000115_gene356	3.001e-57	214.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
DYD2_k127_4664482_10	269797.Mbar_A2012	7.802e-22	104.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_4664482_1	1121272.KB903283_gene5019	2.48e-77	286.0	COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
DYD2_k127_4664482_6	1267535.KB906767_gene1301	4.645e-35	148.0	COG0122@1|root,COG0122@2|Bacteria,3Y7N6@57723|Acidobacteria	57723|Acidobacteria	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
DYD2_k127_4664482_19	1041930.Mtc_2201	6.021e-05	54.0	COG2104@1|root,arCOG00535@2157|Archaea,2Y205@28890|Euryarchaeota,2NBCK@224756|Methanomicrobia	224756|Methanomicrobia	H	Sulfur transfer protein involved in thiamine biosynthesis	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DYD2_k127_4664482_2	1121346.KB899829_gene621	4.078e-63	228.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,26RQZ@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
DYD2_k127_4664482_11	593750.Metfor_1981	1.782e-18	88.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
DYD2_k127_4664482_8	926550.CLDAP_00400	1.826e-26	120.0	COG1051@1|root,COG1051@2|Bacteria,2G77J@200795|Chloroflexi	200795|Chloroflexi	F	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
DYD2_k127_4664482_9	1041930.Mtc_1067	5.196e-24	116.0	COG0350@1|root,arCOG02724@2157|Archaea,2XZSR@28890|Euryarchaeota,2N9ZT@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
DYD2_k127_4664482_13	1041930.Mtc_1880	5.81e-13	78.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,2N9TV@224756|Methanomicrobia	224756|Methanomicrobia	F	adenylyl cyclase CyaB	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
DYD2_k127_4664482_20	314230.DSM3645_19438	0.0003759	47.0	COG1437@1|root,COG1437@2|Bacteria,2J05M@203682|Planctomycetes	203682|Planctomycetes	F	COG1437 Adenylate cyclase class 2 (thermophilic)	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
DYD2_k127_4664482_0	1254432.SCE1572_45980	2.712e-115	382.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YY6R@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
DYD2_k127_4664482_5	1386089.N865_05350	6.946e-40	173.0	COG4733@1|root,COG4733@2|Bacteria,2I7XV@201174|Actinobacteria,4FK2V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
DYD2_k127_4664482_16	1236902.ANAS01000023_gene3280	1.681e-10	73.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4EI3T@85012|Streptosporangiales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_4664482_15	498848.TaqDRAFT_3726	3.656e-11	71.0	COG3437@1|root,COG3437@2|Bacteria,1WI9N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
DYD2_k127_4664482_17	1286106.MPL1_03093	1.104e-09	69.0	COG2865@1|root,COG2865@2|Bacteria,1RDDZ@1224|Proteobacteria,1S277@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4664482_7	211114.JOEF01000007_gene931	1.074e-34	153.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4E0UQ@85010|Pseudonocardiales	201174|Actinobacteria	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
DYD2_k127_4664482_12	413816.BBJP01000059_gene2687	4.306e-14	87.0	COG1378@1|root,arCOG02037@2157|Archaea,2XT5T@28890|Euryarchaeota,23SZB@183963|Halobacteria	183963|Halobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_4664482_18	438753.AZC_2751	3.906e-07	64.0	COG1018@1|root,COG3290@1|root,COG1018@2|Bacteria,COG3290@2|Bacteria,1QWJA@1224|Proteobacteria,2TWZ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4
DYD2_k127_4664482_14	1229203.KI301992_gene577	4.725e-12	80.0	COG2208@1|root,COG2208@2|Bacteria,2GKEF@201174|Actinobacteria,3UXHV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,PAS_3,PAS_4,SpoIIE
DYD2_k127_4664482_4	673860.AciM339_0770	7.603e-54	199.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,3F2P4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
DYD2_k127_46716_2	858215.Thexy_0353	2.632e-46	170.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,42G84@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
DYD2_k127_46716_0	439481.Aboo_0862	4.8e-76	261.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,3F2IX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
DYD2_k127_46716_1	1094980.Mpsy_1500	9.486e-72	253.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,2N993@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
DYD2_k127_46716_4	387631.Asulf_02062	8.733e-27	111.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2476N@183980|Archaeoglobi	183980|Archaeoglobi	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
DYD2_k127_46716_5	1385518.N798_17360	1.459e-08	61.0	COG4430@1|root,COG4430@2|Bacteria,2IN25@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
DYD2_k127_46716_6	456442.Mboo_0795	6.233e-06	59.0	COG0457@1|root,COG0642@1|root,arCOG02385@1|root,arCOG02385@2157|Archaea,arCOG03038@2157|Archaea,arCOG06192@2157|Archaea	2157|Archaea	T	TIGRFAM PAS sensor protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PAS,PAS_4,PAS_9,Peptidase_M10,Pkinase,Response_reg,TPR_1,TPR_2,TPR_8
DYD2_k127_46716_3	869210.Marky_1547	4.243e-41	161.0	COG4122@1|root,COG4122@2|Bacteria,1WKHV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
DYD2_k127_472094_4	326424.FRAAL5004	5.398e-09	60.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4ERSZ@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1599	Histidinol_dh
DYD2_k127_472094_1	573063.Metin_0781	7.538e-82	281.0	COG0040@1|root,arCOG02208@2157|Archaea,2XTZ3@28890|Euryarchaeota,23QIY@183939|Methanococci	183939|Methanococci	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
DYD2_k127_472094_0	304371.MCP_0802	1.247e-111	380.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
DYD2_k127_472094_3	368407.Memar_2290	1.189e-19	95.0	COG2083@1|root,arCOG01921@2157|Archaea	2157|Archaea	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
DYD2_k127_472094_2	1094980.Mpsy_0483	1.433e-26	123.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota	28890|Euryarchaeota	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
DYD2_k127_4771253_2	1120971.AUCA01000030_gene55	2.147e-15	80.0	COG1565@1|root,COG1565@2|Bacteria,1V2II@1239|Firmicutes,4HHGV@91061|Bacilli,278C9@186823|Alicyclobacillaceae	91061|Bacilli	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
DYD2_k127_4771253_0	309801.trd_1590	3.409e-46	180.0	COG1565@1|root,COG1565@2|Bacteria,2G8NS@200795|Chloroflexi,27Y3B@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
DYD2_k127_4771253_1	471852.Tcur_4983	4.561e-18	87.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,4EKGC@85012|Streptosporangiales	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	ytjA	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
DYD2_k127_4771253_3	873533.HMPREF0663_10772	8.194e-10	69.0	COG2050@1|root,COG2050@2|Bacteria,4NRF7@976|Bacteroidetes,2G31E@200643|Bacteroidia	976|Bacteroidetes	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_4807540_20	1380390.JIAT01000009_gene2018	6.552e-32	128.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,4CQEK@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
DYD2_k127_4807540_30	497964.CfE428DRAFT_6231	6.119e-21	104.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,46S9G@74201|Verrucomicrobia	74201|Verrucomicrobia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
DYD2_k127_4807540_0	70601.3257107	7.541e-216	687.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,242P8@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
DYD2_k127_4807540_1	269797.Mbar_A0976	3.956e-167	535.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
DYD2_k127_4807540_5	1122179.KB890429_gene3707	3.282e-99	349.0	COG3367@1|root,COG3367@2|Bacteria,4NGXN@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
DYD2_k127_4807540_19	1396141.BATP01000022_gene477	1.794e-32	136.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_5,CHB_HEX_C_1,Exo_endo_phos,Hint_2,Laminin_G_3,Lysyl_oxidase,PPC,Peptidase_S8,SLH
DYD2_k127_4807540_8	1151117.AJLF01000001_gene1098	9.464e-89	314.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,243XG@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4807540_32	666685.R2APBS1_3944	3.022e-13	83.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1X7MS@135614|Xanthomonadales	135614|Xanthomonadales	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
DYD2_k127_4807540_25	1054217.TALC_01268	4.305e-27	123.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y0ZN@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
DYD2_k127_4807540_36	1294265.JCM21738_1994	4.71e-05	53.0	COG0167@1|root,COG0167@2|Bacteria,1TRFE@1239|Firmicutes,4HDHX@91061|Bacilli,1ZC3E@1386|Bacillus	91061|Bacilli	F	Dihydroorotate dehydrogenase	-	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DYD2_k127_4807540_21	358681.BBR47_38970	7.154e-32	133.0	COG0167@1|root,COG0167@2|Bacteria,1TRFE@1239|Firmicutes,4HDHX@91061|Bacilli,26WBA@186822|Paenibacillaceae	91061|Bacilli	F	Dihydroorotate dehydrogenase	-	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
DYD2_k127_4807540_34	1502724.FF80_01533	2.58e-05	54.0	2DPP7@1|root,332UY@2|Bacteria,1N75H@1224|Proteobacteria,2UFXZ@28211|Alphaproteobacteria,3N8UZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
DYD2_k127_4807540_27	273116.14325429	4.717e-23	106.0	COG4741@1|root,arCOG05252@2157|Archaea,2XYG2@28890|Euryarchaeota	28890|Euryarchaeota	F	Endonuclease related to archaeal Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
DYD2_k127_4807540_10	479437.Elen_3012	3.878e-59	217.0	COG4294@1|root,COG4294@2|Bacteria,2GQBS@201174|Actinobacteria	201174|Actinobacteria	L	UV-endonuclease uvde	-	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
DYD2_k127_4807540_17	690850.Desaf_1348	2.292e-45	183.0	2DM0H@1|root,316A1@2|Bacteria,1N0X9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4807540_22	456320.Mvol_0820	1.312e-30	128.0	COG0288@1|root,arCOG02860@2157|Archaea,2XX8F@28890|Euryarchaeota,23QXP@183939|Methanococci	183939|Methanococci	P	PFAM Carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
DYD2_k127_4807540_38	1336235.JAEG01000007_gene1522	0.0007031	47.0	COG2336@1|root,COG2336@2|Bacteria,1N7H2@1224|Proteobacteria,2UEKP@28211|Alphaproteobacteria,4BK2Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	SpoVT / AbrB like domain	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
DYD2_k127_4807540_31	246969.TAM4_1862	2.268e-15	81.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
DYD2_k127_4807540_29	1288484.APCS01000050_gene220	1.44e-21	105.0	2AGS6@1|root,31703@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4807540_24	273116.14325541	4.866e-28	115.0	COG2440@1|root,arCOG01984@2157|Archaea,2XYN9@28890|Euryarchaeota,242HR@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO
DYD2_k127_4807540_3	273116.14325540	1.8e-108	365.0	COG0644@1|root,arCOG00570@2157|Archaea,2XV3Q@28890|Euryarchaeota,242AZ@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD dependent oxidoreductase	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
DYD2_k127_4807540_28	1094980.Mpsy_0484	8.099e-23	109.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota	28890|Euryarchaeota	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
DYD2_k127_4807540_2	439481.Aboo_1162	1.987e-135	444.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,3F2GT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
DYD2_k127_4807540_7	589924.Ferp_2205	3.519e-91	313.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,245V2@183980|Archaeoglobi	183980|Archaeoglobi	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
DYD2_k127_4807540_11	84531.JMTZ01000014_gene2827	3.781e-55	218.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X8D9@135614|Xanthomonadales	135614|Xanthomonadales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_4807540_14	224719.Abm4_1226	1.305e-50	192.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23NK4@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
DYD2_k127_4807540_23	1448860.BBJO01000003_gene2464	1.652e-28	128.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7G3@28890|Euryarchaeota,241GP@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_4807540_37	880072.Desac_0610	0.0002463	52.0	COG0863@1|root,COG0863@2|Bacteria,1R8XS@1224|Proteobacteria	1224|Proteobacteria	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
DYD2_k127_4807540_6	1150864.MILUP08_43971	1.697e-93	324.0	COG0641@1|root,COG0641@2|Bacteria,2GMTV@201174|Actinobacteria,4DB9E@85008|Micromonosporales	201174|Actinobacteria	C	Radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
DYD2_k127_4807540_16	298655.KI912266_gene3287	4.84e-49	201.0	COG0641@1|root,COG0641@2|Bacteria,2IIR6@201174|Actinobacteria	201174|Actinobacteria	C	radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4807540_12	298655.KI912266_gene3286	3.069e-52	197.0	2BK9Q@1|root,32EPW@2|Bacteria,2H0WI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4807540_18	298655.KI912266_gene3283	1.774e-41	164.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
DYD2_k127_4807540_35	797303.Natpe_3481	4.304e-05	56.0	COG3398@1|root,arCOG02611@2157|Archaea,2XX30@28890|Euryarchaeota,23VMW@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_4807540_39	397948.Cmaq_1856	0.0007079	51.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DYD2_k127_4807540_13	215803.DB30_8734	1.395e-51	190.0	COG0702@1|root,COG0702@2|Bacteria,1MZG7@1224|Proteobacteria,42UCW@68525|delta/epsilon subdivisions,2WQWQ@28221|Deltaproteobacteria,2YV6G@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
DYD2_k127_4807540_26	1120950.KB892801_gene1765	1.088e-24	111.0	COG0454@1|root,COG0456@2|Bacteria,2GQGN@201174|Actinobacteria,4DS9Y@85009|Propionibacteriales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_4807540_33	1286106.MPL1_03960	3.631e-08	67.0	2EMIV@1|root,33F7F@2|Bacteria,1P8R6@1224|Proteobacteria,1SWDY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4807540_4	1121382.JQKG01000056_gene3765	1.57e-102	348.0	COG1960@1|root,COG1960@2|Bacteria,1WITX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_4807540_9	1174528.JH992898_gene1276	4.528e-65	234.0	2B0GJ@1|root,31SU3@2|Bacteria,1G4WP@1117|Cyanobacteria,1JMK7@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_4807540_15	1122138.AQUZ01000042_gene3363	2.846e-50	191.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4DQIS@85009|Propionibacteriales	201174|Actinobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
DYD2_k127_4876566_1	938288.HG326224_gene1637	6.794e-48	174.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,267RC@186813|unclassified Clostridiales	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
DYD2_k127_4876566_3	349124.Hhal_1369	1.699e-36	161.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1WWM9@135613|Chromatiales	135613|Chromatiales	O	Cytochrome c-type biogenesis protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
DYD2_k127_4876566_5	215358.XP_010744617.1	1.124e-11	75.0	COG1011@1|root,KOG3085@2759|Eukaryota,38CID@33154|Opisthokonta,3BJEU@33208|Metazoa,3CZ86@33213|Bilateria,47ZW9@7711|Chordata,496SZ@7742|Vertebrata,49URB@7898|Actinopterygii	33208|Metazoa	S	Haloacid dehalogenase-like hydrolase	HDHD3	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
DYD2_k127_4876566_4	243231.GSU1004	8.159e-35	148.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,43T97@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Nitrogen fixation master sensor histidine kinase, PAS domain-containing	gnfL	-	2.7.13.3	ko:K02668,ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
DYD2_k127_4876566_6	709986.Deima_2231	8.175e-08	63.0	COG4251@1|root,COG4251@2|Bacteria,1WNFF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
DYD2_k127_4876566_7	279238.Saro_2666	2.233e-06	62.0	COG3920@1|root,COG5002@1|root,COG3920@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TXPT@28211|Alphaproteobacteria,2KEIQ@204457|Sphingomonadales	204457|Sphingomonadales	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS_4
DYD2_k127_4876566_2	351160.RCIX1839	2.318e-42	163.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,2N9VP@224756|Methanomicrobia	224756|Methanomicrobia	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
DYD2_k127_4876566_0	485913.Krac_7275	3.626e-119	402.0	COG0578@1|root,COG0578@2|Bacteria,2G63S@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
DYD2_k127_4898899_0	1463895.JODA01000023_gene4126	3.904e-29	123.0	COG5592@1|root,COG5592@2|Bacteria,2IGW0@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
DYD2_k127_4898899_2	1227499.C493_02141	7.297e-05	55.0	COG1413@1|root,COG1520@1|root,COG5635@1|root,arCOG02482@2157|Archaea,arCOG02966@2157|Archaea,arCOG02967@2157|Archaea,2XUI1@28890|Euryarchaeota,23UYQ@183963|Halobacteria	183963|Halobacteria	T	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	Cnd1,HEAT_2,PQQ_2,PQQ_3
DYD2_k127_4898899_1	1382306.JNIM01000001_gene1584	2.049e-09	64.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
DYD2_k127_4946519_0	1380354.JIAN01000008_gene3362	2.132e-51	209.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
DYD2_k127_4946519_2	324602.Caur_3219	6.579e-05	57.0	COG2730@1|root,COG3209@1|root,COG2730@2|Bacteria,COG3209@2|Bacteria,2G6KZ@200795|Chloroflexi,376AQ@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
DYD2_k127_4946519_1	452638.Pnec_0286	1.651e-05	53.0	2E3B5@1|root,32YAP@2|Bacteria,1N7KQ@1224|Proteobacteria,2VT1R@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
DYD2_k127_4969974_6	1397696.KK211189_gene1986	0.0003055	52.0	COG4347@1|root,COG4347@2|Bacteria,1V1NI@1239|Firmicutes,4HFTW@91061|Bacilli	91061|Bacilli	S	membrane	ypjA	-	-	-	-	-	-	-	-	-	-	-	DUF1405
DYD2_k127_4969974_7	795797.C497_04567	0.0003676	52.0	COG4347@1|root,arCOG02940@2157|Archaea,2XTV6@28890|Euryarchaeota,23UNZ@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1405
DYD2_k127_4969974_2	935866.JAER01000009_gene782	8.757e-64	228.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4DP1S@85009|Propionibacteriales	201174|Actinobacteria	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
DYD2_k127_4969974_1	290318.Cvib_1699	4.163e-71	268.0	COG0240@1|root,COG0240@2|Bacteria,1FDCM@1090|Chlorobi	1090|Chlorobi	I	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
DYD2_k127_4969974_5	667632.KB890164_gene1786	4.235e-07	60.0	COG0346@1|root,COG0346@2|Bacteria,1RG1A@1224|Proteobacteria,2W2S8@28216|Betaproteobacteria,1K7Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
DYD2_k127_4969974_4	351160.LRC236	9.911e-17	87.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2N9X3@224756|Methanomicrobia	224756|Methanomicrobia	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
DYD2_k127_4969974_0	937777.Deipe_2024	8.204e-99	342.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
DYD2_k127_4969974_3	342949.PNA2_1701	1.543e-43	166.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,242JZ@183968|Thermococci	183968|Thermococci	S	Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins.	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
DYD2_k127_5024875_0	309801.trd_1740	0.0	1171.0	COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,27XGQ@189775|Thermomicrobia	189775|Thermomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
DYD2_k127_5034585_2	886293.Sinac_6957	2.146e-36	139.0	COG2010@1|root,COG2010@2|Bacteria,2J2GM@203682|Planctomycetes	203682|Planctomycetes	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
DYD2_k127_5034585_1	1236689.MMALV_05760	3.144e-106	354.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,3F2G7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
DYD2_k127_5034585_3	269797.Mbar_A2122	2.594e-16	81.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y05G@28890|Euryarchaeota,2NA4X@224756|Methanomicrobia	224756|Methanomicrobia	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
DYD2_k127_5034585_5	1094980.Mpsy_1960	1.551e-05	48.0	arCOG10361@1|root,arCOG10361@2157|Archaea,2Y5Z6@28890|Euryarchaeota,2NBEF@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5034585_4	932213.SPM24T3_04007	9.144e-08	67.0	COG3210@1|root,COG3420@1|root,COG4932@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,1QUXB@1224|Proteobacteria,1T24R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
DYD2_k127_5034585_0	797209.ZOD2009_21577	1.162e-155	520.0	COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG00449@2157|Archaea,2XTX6@28890|Euryarchaeota,23SWT@183963|Halobacteria	183963|Halobacteria	E	COG0531 Amino acid transporters	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2,Usp
DYD2_k127_5041519_0	313612.L8106_19216	1.06e-100	342.0	COG1215@1|root,COG1215@2|Bacteria,1G3BH@1117|Cyanobacteria,1H8YM@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferases involved in cell wall biogenesis	-	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
DYD2_k127_5041519_5	1996.JOFO01000003_gene6255	5.096e-08	64.0	COG0666@1|root,COG1413@1|root,COG0666@2|Bacteria,COG1413@2|Bacteria,2I9YH@201174|Actinobacteria,4EFI0@85012|Streptosporangiales	201174|Actinobacteria	C	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,HEAT_2
DYD2_k127_5041519_4	511051.CSE_03160	1.943e-09	65.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
DYD2_k127_5041519_1	269797.Mbar_A2903	7.361e-41	163.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,2N9AW@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15,2.7.1.213,2.7.1.73	ko:K00852,ko:K22026	ko00030,ko00230,ko00240,map00030,map00230,map00240	-	R00513,R01051,R01131,R01228,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2903	PfkB
DYD2_k127_5041519_3	1455608.JDTH01000001_gene3128	1.028e-10	73.0	COG1931@1|root,arCOG01043@2157|Archaea,2XWHA@28890|Euryarchaeota,23VAH@183963|Halobacteria	183963|Halobacteria	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
DYD2_k127_5041519_2	1210908.HSB1_37300	1.688e-38	157.0	COG1184@1|root,arCOG01127@2157|Archaea,2XUMH@28890|Euryarchaeota,23SF4@183963|Halobacteria	183963|Halobacteria	J	Belongs to the eIF-2B alpha beta delta subunits family	tif2Ba	-	-	-	-	-	-	-	-	-	-	-	IF-2B,NUDIX
DYD2_k127_5064737_10	1054217.TALC_00146	2.373e-28	123.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,241T6@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
DYD2_k127_5064737_1	266117.Rxyl_0103	3.768e-88	325.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,2GK25@201174|Actinobacteria,4CQ6R@84995|Rubrobacteria	84995|Rubrobacteria	T	PFAM ATP-binding region, ATPase-like histidine kinase A-like	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA
DYD2_k127_5064737_16	351160.RCIX1052	1.012e-08	63.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
DYD2_k127_5064737_17	351160.RCIX1052	1.942e-05	59.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
DYD2_k127_5064737_13	693661.Arcve_2014	6.707e-18	97.0	COG1853@1|root,arCOG02017@2157|Archaea,2XWBK@28890|Euryarchaeota	28890|Euryarchaeota	S	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
DYD2_k127_5064737_7	1278073.MYSTI_01163	2.023e-50	200.0	COG1994@1|root,COG2524@1|root,COG1994@2|Bacteria,COG2524@2|Bacteria,1MY9R@1224|Proteobacteria,42R1V@68525|delta/epsilon subdivisions,2WN7S@28221|Deltaproteobacteria,2YVUM@29|Myxococcales	28221|Deltaproteobacteria	K	zinc metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
DYD2_k127_5064737_14	1392498.JQLH01000001_gene285	2.594e-11	75.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,1HXV2@117743|Flavobacteriia,2PI0B@252356|Maribacter	976|Bacteroidetes	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
DYD2_k127_5064737_5	426117.M446_6045	2.169e-56	211.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,1JYE5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF692)	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
DYD2_k127_5064737_8	1144275.COCOR_07609	2.024e-42	165.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,Methyltransf_25
DYD2_k127_5064737_12	1192034.CAP_0138	1.795e-20	108.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
DYD2_k127_5064737_2	485913.Krac_11137	4.302e-78	276.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
DYD2_k127_5064737_4	387631.Asulf_00525	3.802e-61	231.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,245VW@183980|Archaeoglobi	183980|Archaeoglobi	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
DYD2_k127_5064737_9	688269.Theth_1417	6.317e-38	161.0	COG0301@1|root,COG0301@2|Bacteria,2GC7N@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
DYD2_k127_5064737_15	691883.XP_009493316.1	8.719e-09	67.0	COG2234@1|root,KOG2195@2759|Eukaryota,39WQU@33154|Opisthokonta	2759|Eukaryota	O	Belongs to the peptidase M28 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
DYD2_k127_5064737_3	439481.Aboo_0637	1.096e-62	226.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,3F2J1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
DYD2_k127_5064737_11	673860.AciM339_0463	1.093e-21	104.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,3F3BI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_5064737_0	264462.Bd2784	0.0	1028.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2MTH2@213481|Bdellovibrionales,2WIIV@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	aconitate hydratase	aco	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
DYD2_k127_5113709_3	1206101.AZXC01000021_gene2176	7.686e-08	66.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_5113709_0	477974.Daud_2151	9.51e-81	280.0	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,26028@186807|Peptococcaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
DYD2_k127_5113709_4	1122194.AUHU01000002_gene2828	7.315e-07	59.0	2C983@1|root,32RNS@2|Bacteria,1MZHF@1224|Proteobacteria,1SASK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5113709_1	452637.Oter_1575	6.629e-43	168.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
DYD2_k127_5113709_5	751945.Theos_0362	2.398e-05	57.0	COG1409@1|root,COG1409@2|Bacteria,1WINK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DYD2_k127_5113709_6	387631.Asulf_01695	0.000877	44.0	COG4068@1|root,arCOG04390@2157|Archaea	2157|Archaea	S	Uncharacterized protein containing a Zn-ribbon (DUF2116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2116
DYD2_k127_5113709_2	186497.PF1407	4.89e-39	154.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,242XX@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DYD2_k127_5125974_2	926550.CLDAP_12420	3.382e-12	69.0	COG1131@1|root,COG1131@2|Bacteria,2G6IS@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
DYD2_k127_5125974_4	868131.MSWAN_2253	2.114e-05	57.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,23NM6@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
DYD2_k127_5125974_3	1246995.AFR_38620	2.477e-09	67.0	COG0121@1|root,COG0121@2|Bacteria,2GXCD@201174|Actinobacteria,4DB50@85008|Micromonosporales	201174|Actinobacteria	S	Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	egtC	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006518,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0019439,GO:0019752,GO:0032991,GO:0034641,GO:0042219,GO:0042398,GO:0043171,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0061672,GO:0071704,GO:0071944,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1905368	3.5.1.118	ko:K07008	ko00340,map00340	-	R11021	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	GATase_6
DYD2_k127_5125974_0	1173022.Cri9333_4069	6.382e-126	413.0	COG2141@1|root,COG2141@2|Bacteria,1G3QW@1117|Cyanobacteria,1H9JG@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM Luciferase-like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_5125974_1	237368.SCABRO_03660	6.023e-78	278.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	3.2.1.40	ko:K05989,ko:K20541	-	-	-	-	ko00000,ko01000,ko02000	4.D.3.1.6	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,fn3
DYD2_k127_5130392_0	861299.J421_1936	1.004e-185	592.0	COG3158@1|root,COG3158@2|Bacteria,1ZTCK@142182|Gemmatimonadetes	2|Bacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
DYD2_k127_5130392_1	1163408.UU9_07376	4.776e-98	333.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RRCR@1236|Gammaproteobacteria,1X5H9@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N,HTH_13
DYD2_k127_5130392_4	591158.SSMG_03418	6.117e-37	150.0	COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	2.1.1.288	ko:K15942,ko:K21172	ko01057,ko01059,ko01130,map01057,map01059,map01130	M00781,M00825	R06675,R06680	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
DYD2_k127_5130392_7	765910.MARPU_10565	4.27e-16	92.0	COG2761@1|root,COG2761@2|Bacteria,1QVUQ@1224|Proteobacteria,1S0JY@1236|Gammaproteobacteria,1X25D@135613|Chromatiales	135613|Chromatiales	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_5
DYD2_k127_5130392_11	1123507.ATVQ01000001_gene901	6.918e-09	69.0	COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria,1W7Y0@1268|Micrococcaceae	201174|Actinobacteria	L	HELICc2	dinG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
DYD2_k127_5130392_2	1380390.JIAT01000012_gene3302	2.116e-43	177.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5130392_5	397278.JOJN01000011_gene1591	3.986e-25	111.0	COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4DR3Y@85009|Propionibacteriales	201174|Actinobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
DYD2_k127_5130392_3	867903.ThesuDRAFT_01268	1.166e-40	163.0	COG4447@1|root,COG4447@2|Bacteria,1TRJ4@1239|Firmicutes,25BU3@186801|Clostridia	186801|Clostridia	S	PFAM BNR Asp-box repeat	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
DYD2_k127_5130392_8	1078020.KEK_05942	2.595e-15	83.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,234GG@1762|Mycobacteriaceae	201174|Actinobacteria	GL	Ribonuclease	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
DYD2_k127_5130392_12	635013.TherJR_2578	8.682e-09	65.0	COG1988@1|root,COG1988@2|Bacteria,1TQFC@1239|Firmicutes,24I12@186801|Clostridia,2622F@186807|Peptococcaceae	186801|Clostridia	S	membrane-bound metal-dependent hydrolase (DUF457)	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
DYD2_k127_5130392_9	96561.Dole_0490	1.412e-13	80.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WKJV@28221|Deltaproteobacteria,2MHMF@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC,PA14
DYD2_k127_5130392_13	1380356.JNIK01000017_gene2993	1.312e-08	62.0	COG4454@1|root,COG4454@2|Bacteria,2GS6Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
DYD2_k127_5130392_6	680198.SCAB_77801	8.419e-19	102.0	COG0346@1|root,COG0346@2|Bacteria,2IM43@201174|Actinobacteria	201174|Actinobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
DYD2_k127_5130392_10	1123508.JH636441_gene3650	3.752e-10	66.0	COG0346@1|root,COG0346@2|Bacteria,2J160@203682|Planctomycetes	203682|Planctomycetes	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
DYD2_k127_5163402_9	304371.MCP_2072	7.231e-22	108.0	COG1082@1|root,arCOG01895@2157|Archaea	2157|Archaea	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,NeuB,SAF
DYD2_k127_5163402_1	693661.Arcve_1997	2.831e-171	569.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,245SJ@183980|Archaeoglobi	183980|Archaeoglobi	V	SMART Nucleotide binding protein, PINc	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
DYD2_k127_5163402_3	426355.Mrad2831_4146	1.38e-57	220.0	COG2357@1|root,COG2357@2|Bacteria,1RDE9@1224|Proteobacteria,2UHFA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	RelA_SpoT
DYD2_k127_5163402_5	439481.Aboo_0209	2.991e-51	194.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,3F2RT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	PFAM tRNA methyltransferase complex GCD14 subunit	trmI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0031515,GO:0032991,GO:0034708,GO:0043527,GO:0044424,GO:0044444,GO:0044464,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
DYD2_k127_5163402_14	1123320.KB889563_gene6467	2.839e-09	71.0	COG2133@1|root,COG3291@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria	201174|Actinobacteria	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1349,GSDH,PKD,RicinB_lectin_2,ThuA
DYD2_k127_5163402_10	2045.KR76_02960	1.556e-21	110.0	COG4667@1|root,COG4667@2|Bacteria,2I8R7@201174|Actinobacteria	201174|Actinobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
DYD2_k127_5163402_4	224719.Abm4_0334	5.216e-57	225.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,23NS2@183925|Methanobacteria	183925|Methanobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
DYD2_k127_5163402_8	450380.JPSY01000001_gene84	2.488e-30	130.0	COG1546@1|root,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4FPN9@85023|Microbacteriaceae	201174|Actinobacteria	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
DYD2_k127_5163402_2	304371.MCP_0861	1.612e-145	473.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia	224756|Methanomicrobia	G	Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
DYD2_k127_5163402_15	402881.Plav_1001	2.656e-08	68.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2U0ME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GQ	COG2931, RTX toxins and related Ca2 -binding proteins	exsH	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Glyco_hydro_16,HemolysinCabind,W_rich_C
DYD2_k127_5163402_16	195522.BD01_1207	2.814e-08	66.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	183968|Thermococci	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_5163402_11	926550.CLDAP_29030	2.53e-21	102.0	COG4276@1|root,COG4276@2|Bacteria,2G9EV@200795|Chloroflexi	200795|Chloroflexi	S	Pfam Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5163402_0	673860.AciM339_0956	4.471e-214	685.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,3F2F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
DYD2_k127_5163402_13	573064.Mefer_1289	2.168e-15	84.0	COG1658@1|root,arCOG01486@2157|Archaea,2XYTB@28890|Euryarchaeota,23R5F@183939|Methanococci	183939|Methanococci	L	SMART Toprim sub domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_4
DYD2_k127_5163402_6	192952.MM_0247	1.024e-34	141.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,2N9J9@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3
DYD2_k127_5163402_7	1385520.N802_12900	6.193e-34	143.0	COG0451@1|root,COG0451@2|Bacteria,2GN90@201174|Actinobacteria,4FJXP@85021|Intrasporangiaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DYD2_k127_5163402_17	67332.FM21_12615	5.952e-06	54.0	COG0526@1|root,COG0526@2|Bacteria,2IKMI@201174|Actinobacteria	201174|Actinobacteria	CO	Thioredoxin	thiX	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
DYD2_k127_5163402_12	928724.SacglDRAFT_04175	1.612e-16	87.0	2AN8T@1|root,31D6V@2|Bacteria,2IHRU@201174|Actinobacteria,4E3N2@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
DYD2_k127_5163402_18	485916.Dtox_2444	0.0007426	51.0	COG5482@1|root,COG5482@2|Bacteria	2|Bacteria	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5172630_7	1128427.KB904821_gene4158	2.655e-53	201.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
DYD2_k127_5172630_1	439481.Aboo_0061	8.58e-139	453.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,3F2G1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
DYD2_k127_5172630_9	1173027.Mic7113_2828	5.814e-21	106.0	COG0642@1|root,COG2199@1|root,COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_5172630_6	867845.KI911784_gene2182	4.561e-86	301.0	COG2379@1|root,COG2379@2|Bacteria,2G5RZ@200795|Chloroflexi,374XG@32061|Chloroflexia	32061|Chloroflexia	C	PFAM MOFRL domain protein	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
DYD2_k127_5172630_10	1517681.HW45_26490	3.993e-11	76.0	2FB63@1|root,343CD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5172630_0	309799.DICTH_0773	1.477e-141	467.0	COG1384@1|root,COG1384@2|Bacteria	2|Bacteria	J	tRNA binding	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
DYD2_k127_5172630_2	215803.DB30_7020	2.572e-137	448.0	COG2201@1|root,COG2201@2|Bacteria,1RCWE@1224|Proteobacteria,42S7B@68525|delta/epsilon subdivisions,2WNKM@28221|Deltaproteobacteria,2YZ8S@29|Myxococcales	28221|Deltaproteobacteria	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
DYD2_k127_5172630_3	1211813.CAPH01000023_gene1939	5.402e-131	434.0	COG1449@1|root,COG1449@2|Bacteria,4NFXW@976|Bacteroidetes,2FMRY@200643|Bacteroidia,22U3N@171550|Rikenellaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 57 family	amyA	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
DYD2_k127_5172630_5	263820.PTO1239	1.016e-92	318.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,2424E@183967|Thermoplasmata	183967|Thermoplasmata	M	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_5172630_4	1041930.Mtc_0451	2.857e-118	406.0	COG3387@1|root,arCOG03285@2157|Archaea,2XUZ8@28890|Euryarchaeota,2NAP9@224756|Methanomicrobia	224756|Methanomicrobia	G	COG3387 Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1916	Glyco_hydro_15
DYD2_k127_5172630_11	1395587.P364_0126320	0.0005173	52.0	COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,4HA87@91061|Bacilli,26UNI@186822|Paenibacillaceae	91061|Bacilli	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
DYD2_k127_5172630_8	518766.Rmar_0580	2.793e-31	140.0	COG0406@1|root,COG0406@2|Bacteria,4NFX5@976|Bacteroidetes,1FJ9S@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglycerate mutase family	gpm	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
DYD2_k127_5173549_2	1242864.D187_007053	3.795e-05	56.0	COG4932@1|root,COG4932@2|Bacteria,1P94X@1224|Proteobacteria,4333Y@68525|delta/epsilon subdivisions,2WYD5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
DYD2_k127_5173549_1	596151.DesfrDRAFT_1255	1.04e-08	62.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M8VA@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
DYD2_k127_5173549_0	671065.MetMK1DRAFT_00021540	1.641e-20	96.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
DYD2_k127_5177010_1	1125863.JAFN01000001_gene1462	1.852e-121	396.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
DYD2_k127_5177010_7	414684.RC1_2167	1.501e-60	218.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061,ko:K06889	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Chlorophyllase2,DLH,Hydrolase_4
DYD2_k127_5177010_6	1227484.C471_10515	6.499e-62	243.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,23S80@183963|Halobacteria	183963|Halobacteria	BQ	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein	hda1	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
DYD2_k127_5177010_13	273075.Ta1352	4.01e-06	56.0	COG0494@1|root,arCOG01078@2157|Archaea	2157|Archaea	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	apa	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
DYD2_k127_5177010_5	69014.TK2168	3.756e-70	267.0	COG1750@1|root,arCOG01937@2157|Archaea,2XUEB@28890|Euryarchaeota,242IS@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
DYD2_k127_5177010_8	1122939.ATUD01000005_gene2706	6.478e-39	168.0	COG1335@1|root,COG1335@2|Bacteria,2GPXN@201174|Actinobacteria,4CQB9@84995|Rubrobacteria	84995|Rubrobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
DYD2_k127_5177010_0	290397.Adeh_1896	8.281e-289	914.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2YTWQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
DYD2_k127_5177010_10	1192034.CAP_6484	3.21e-35	140.0	COG0454@1|root,COG0454@2|Bacteria,1QTZ4@1224|Proteobacteria,42SGX@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	Acetyltransferase (GNAT) family	MA20_02285	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
DYD2_k127_5177010_11	644966.Tmar_2024	4.966e-12	77.0	COG4089@1|root,COG4089@2|Bacteria,1V17T@1239|Firmicutes,24D36@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
DYD2_k127_5177010_4	338969.Rfer_1881	6.375e-77	267.0	COG3420@1|root,COG5492@1|root,COG3420@2|Bacteria,COG5492@2|Bacteria,1PZBJ@1224|Proteobacteria,2W16C@28216|Betaproteobacteria	28216|Betaproteobacteria	NP	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF3494
DYD2_k127_5177010_9	1125863.JAFN01000001_gene2936	1.056e-37	160.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02668,ko:K07710	ko02020,map02020	M00500,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
DYD2_k127_5177010_14	414684.RC1_1758	1.893e-05	58.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2JQ05@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0643 Chemotaxis protein histidine kinase and related kinases	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
DYD2_k127_5177010_3	1337936.IJ00_01025	1.429e-97	336.0	COG0467@1|root,COG0467@2|Bacteria,1G2XC@1117|Cyanobacteria,1HTZ7@1161|Nostocales	1117|Cyanobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
DYD2_k127_5177010_2	644281.MFS40622_0827	2.946e-99	339.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,23QBT@183939|Methanococci	183939|Methanococci	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
DYD2_k127_5177010_12	1173025.GEI7407_2535	9.638e-09	66.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1FZVR@1117|Cyanobacteria,1H8C7@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DYD2_k127_5179399_4	926550.CLDAP_28350	6.611e-25	124.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
DYD2_k127_5179399_7	309800.C498_06128	1.586e-09	73.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
DYD2_k127_5179399_1	246969.TAM4_1127	2.595e-110	368.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
DYD2_k127_5179399_5	529709.PYCH_02840	8.997e-21	108.0	COG1721@1|root,arCOG02742@2157|Archaea,2XTP9@28890|Euryarchaeota,242WS@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
DYD2_k127_5179399_6	253839.SSNG_07467	1.449e-09	72.0	2B7WC@1|root,3213B@2|Bacteria,2H50F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5179399_0	342949.PNA2_1546	4.841e-142	467.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,242Q1@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K22503	ko00970,map00970	M00359	R05577	RC00055,RC00523	ko00000,ko00001,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
DYD2_k127_5179399_9	1499684.CCNP01000021_gene2872	8.454e-06	53.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,248XN@186801|Clostridia,36FC0@31979|Clostridiaceae	186801|Clostridia	J	L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp	aspS	-	6.1.1.12,6.1.1.23	ko:K01876,ko:K09759	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_2,tRNA_anti-codon
DYD2_k127_5179399_10	1121904.ARBP01000018_gene2643	0.0001379	55.0	COG5295@1|root,COG5295@2|Bacteria,4PHWW@976|Bacteroidetes,47ST5@768503|Cytophagia	976|Bacteroidetes	UW	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5179399_8	457421.CBFG_03812	1.183e-07	66.0	COG5164@1|root,COG5164@2|Bacteria,1VFKD@1239|Firmicutes,24Z10@186801|Clostridia,26CRV@186813|unclassified Clostridiales	186801|Clostridia	K	Collagen triple helix repeat (20 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
DYD2_k127_5179399_3	304371.MCP_2626	9.707e-79	271.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2N93P@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
DYD2_k127_5179399_2	1236689.MMALV_02980	4.908e-90	308.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,3F2GE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
DYD2_k127_5186369_4	1236689.MMALV_00450	1.281e-48	178.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,3F2N7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
DYD2_k127_5186369_0	1123368.AUIS01000005_gene412	3.065e-125	406.0	COG1028@1|root,COG1028@2|Bacteria,1Q7EW@1224|Proteobacteria,1RXZX@1236|Gammaproteobacteria,2NBV7@225057|Acidithiobacillales	225057|Acidithiobacillales	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
DYD2_k127_5186369_1	573064.Mefer_1408	6.244e-71	244.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,23Q5E@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
DYD2_k127_5186369_6	272844.PAB1135	7.932e-15	82.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,242JV@183968|Thermococci	183968|Thermococci	J	RNA binding	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
DYD2_k127_5186369_5	1333523.L593_09020	1.431e-36	142.0	COG0537@1|root,arCOG00419@2157|Archaea,2XXWC@28890|Euryarchaeota,23V8Q@183963|Halobacteria	183963|Halobacteria	F	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit2	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
DYD2_k127_5186369_9	1120973.AQXL01000097_gene899	1.509e-05	56.0	COG4502@1|root,COG4502@2|Bacteria,1V87A@1239|Firmicutes,4HQD9@91061|Bacilli,279SJ@186823|Alicyclobacillaceae	91061|Bacilli	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	M1-795	-	-	-	-	-	-	-	-	-	-	-	NT5C
DYD2_k127_5186369_3	1041930.Mtc_1975	1.705e-54	204.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2N9P3@224756|Methanomicrobia	224756|Methanomicrobia	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
DYD2_k127_5186369_2	1168065.DOK_13939	1.255e-62	235.0	COG1344@1|root,COG1409@1|root,COG1344@2|Bacteria,COG1409@2|Bacteria,1NXRI@1224|Proteobacteria,1S1N6@1236|Gammaproteobacteria,1J9SF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	N	Calcineurin-like phosphoesterase	-	-	3.1.3.2	ko:K14379	ko00740,ko01100,ko04142,ko04380,ko05323,map00740,map01100,map04142,map04380,map05323	-	R00548	RC00017	ko00000,ko00001,ko01000	-	-	-	Metallophos
DYD2_k127_5186369_7	1121939.L861_17950	4.067e-10	70.0	COG0454@1|root,COG0456@2|Bacteria,1R4WE@1224|Proteobacteria,1T021@1236|Gammaproteobacteria,1XNBM@135619|Oceanospirillales	135619|Oceanospirillales	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
DYD2_k127_5186369_10	29540.C481_07021	9.517e-05	52.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_5186369_8	1227484.C471_02475	9.917e-06	57.0	COG3398@1|root,arCOG02611@2157|Archaea,2XX30@28890|Euryarchaeota,23VMW@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
DYD2_k127_5223136_5	67593.Physo127471	4.118e-53	208.0	COG0179@1|root,KOG1535@2759|Eukaryota,3Q8IT@4776|Peronosporales	4776|Peronosporales	T	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.5	ko:K01557	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
DYD2_k127_5223136_6	314278.NB231_13781	3.742e-28	130.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales	135613|Chromatiales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
DYD2_k127_5223136_0	357808.RoseRS_0421	6.335e-192	649.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,37639@32061|Chloroflexia	32061|Chloroflexia	DZ	Regulator of chromosome condensation (RCC1) repeat	-	-	-	-	-	-	-	-	-	-	-	-	RCC1_2
DYD2_k127_5223136_2	309801.trd_0273	3.997e-75	286.0	COG0577@1|root,COG0577@2|Bacteria,2G6CK@200795|Chloroflexi,27Z42@189775|Thermomicrobia	189775|Thermomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
DYD2_k127_5223136_1	479434.Sthe_1775	3.328e-87	298.0	COG1136@1|root,COG1136@2|Bacteria,2G6B5@200795|Chloroflexi,27YCE@189775|Thermomicrobia	189775|Thermomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
DYD2_k127_5223136_3	1536769.P40081_32455	1.405e-74	269.0	COG0697@1|root,COG0697@2|Bacteria,1UZ6C@1239|Firmicutes,4HKQT@91061|Bacilli,26WER@186822|Paenibacillaceae	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_5223136_9	1190606.AJYG01000064_gene1356	8.622e-09	64.0	COG0210@1|root,COG0551@1|root,COG0210@2|Bacteria,COG0551@2|Bacteria,1MVWI@1224|Proteobacteria,1RN1N@1236|Gammaproteobacteria,1XVZH@135623|Vibrionales	135623|Vibrionales	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03658	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C,zf-C4_Topoisom
DYD2_k127_5223136_4	446466.Cfla_2183	1.506e-58	214.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4F23Y@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
DYD2_k127_5223136_7	1268072.PSAB_16780	7.369e-23	108.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,4HAZI@91061|Bacilli,26RXW@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter	zurA	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
DYD2_k127_527932_1	543526.Htur_0919	6.153e-121	398.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,23SK3@183963|Halobacteria	183963|Halobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_527932_21	1307759.JOMJ01000003_gene347	7.375e-10	66.0	2EEAU@1|root,33859@2|Bacteria,1NPX9@1224|Proteobacteria,4367D@68525|delta/epsilon subdivisions,2X0RQ@28221|Deltaproteobacteria,2MD7Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_527932_3	909613.UO65_0660	2.272e-67	245.0	COG2271@1|root,COG2271@2|Bacteria,2IAK4@201174|Actinobacteria,4E0RZ@85010|Pseudonocardiales	201174|Actinobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
DYD2_k127_527932_20	365046.Rta_09130	7.683e-11	76.0	COG1073@1|root,COG1073@2|Bacteria,1RCY0@1224|Proteobacteria	1224|Proteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
DYD2_k127_527932_11	66874.JOFS01000049_gene3200	4.092e-32	141.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_527932_17	1293048.CBMB010000003_gene997	2.143e-16	90.0	COG1378@1|root,arCOG02037@2157|Archaea,2XT5T@28890|Euryarchaeota,23SZB@183963|Halobacteria	183963|Halobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_527932_6	1429851.X548_06645	2.988e-55	211.0	COG3568@1|root,COG3568@2|Bacteria,1PPNP@1224|Proteobacteria,1S9D7@1236|Gammaproteobacteria,1X46I@135614|Xanthomonadales	135614|Xanthomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
DYD2_k127_527932_5	765912.Thimo_2740	1.91e-58	215.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RY2H@1236|Gammaproteobacteria,1WX0H@135613|Chromatiales	135613|Chromatiales	GM	epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
DYD2_k127_527932_12	1122223.KB890687_gene2439	1.035e-29	128.0	COG0204@1|root,COG0204@2|Bacteria,1WJXG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
DYD2_k127_527932_10	1379270.AUXF01000001_gene2282	2.263e-38	162.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Hexapep,Hexapep_2,PP-binding
DYD2_k127_527932_8	439481.Aboo_0227	4.368e-47	187.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,3F2M2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
DYD2_k127_527932_9	485913.Krac_11442	3.722e-43	168.0	COG0580@1|root,COG0580@2|Bacteria	2|Bacteria	U	water channel activity	glpF	-	-	ko:K02440,ko:K06188,ko:K09874	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.12,1.A.8.2	-	-	MIP
DYD2_k127_527932_15	1114856.C496_18828	5.814e-18	94.0	COG0697@1|root,arCOG00271@2157|Archaea,2XTYP@28890|Euryarchaeota,23TQ4@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
DYD2_k127_527932_16	2754.EH55_05380	5.435e-17	86.0	COG1894@1|root,COG1894@2|Bacteria,3TAJW@508458|Synergistetes	508458|Synergistetes	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
DYD2_k127_527932_4	272844.PAB0468	1.361e-66	242.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
DYD2_k127_527932_18	192952.MM_1115	9.718e-16	85.0	arCOG03391@1|root,arCOG03391@2157|Archaea,2Y097@28890|Euryarchaeota,2N9ZQ@224756|Methanomicrobia	224756|Methanomicrobia	S	membrane-bound metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
DYD2_k127_527932_7	1379698.RBG1_1C00001G0454	3.136e-51	193.0	2CEY7@1|root,2Z8CG@2|Bacteria,2NR2B@2323|unclassified Bacteria	2|Bacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_527932_0	1379698.RBG1_1C00001G0453	4.224e-240	769.0	COG1053@1|root,COG1053@2|Bacteria,2NNR9@2323|unclassified Bacteria	2|Bacteria	C	succinate dehydrogenase, flavoprotein subunit	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
DYD2_k127_527932_2	1379698.RBG1_1C00001G0452	4.484e-94	344.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
DYD2_k127_5289264_14	1236689.MMALV_13580	5.12e-19	90.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,3F2SB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	snRNP Sm proteins	lsm	GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
DYD2_k127_5289264_0	439481.Aboo_0814	6.245e-189	608.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,3F2GX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
DYD2_k127_5289264_5	518766.Rmar_1212	3.078e-67	244.0	COG1801@1|root,COG1801@2|Bacteria,4NHAD@976|Bacteroidetes,1FK58@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
DYD2_k127_5289264_12	673860.AciM339_1283	8.383e-24	109.0	arCOG07412@1|root,arCOG07412@2157|Archaea,2Y0S5@28890|Euryarchaeota,3F2T8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5289264_10	67373.JOBF01000028_gene1651	2.694e-25	119.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
DYD2_k127_5289264_6	273063.STK_09740	4.147e-63	237.0	COG0438@1|root,arCOG01408@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
DYD2_k127_5289264_7	521098.Aaci_1667	7.677e-55	216.0	COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,4HFQ8@91061|Bacilli,27899@186823|Alicyclobacillaceae	91061|Bacilli	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
DYD2_k127_5289264_1	1459636.NTE_01913	3.534e-168	547.0	COG0133@1|root,arCOG01433@2157|Archaea,41S87@651137|Thaumarchaeota	651137|Thaumarchaeota	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_5289264_11	523841.HFX_2464	6.542e-25	120.0	COG0135@1|root,arCOG01983@2157|Archaea,2XXCM@28890|Euryarchaeota,23VW3@183963|Halobacteria	183963|Halobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
DYD2_k127_5289264_13	562970.Btus_1720	7.438e-23	114.0	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,4HDZQ@91061|Bacilli,2789J@186823|Alicyclobacillaceae	91061|Bacilli	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
DYD2_k127_5289264_3	1041930.Mtc_0376	3.797e-108	367.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,2N9AU@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
DYD2_k127_5289264_4	358681.BBR47_01720	4.976e-69	240.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli,26SGI@186822|Paenibacillaceae	91061|Bacilli	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	pabA	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01664	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	iYO844.BSU00750	GATase
DYD2_k127_5289264_2	1220534.B655_1147	8.934e-114	381.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,23NQP@183925|Methanobacteria	183925|Methanobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
DYD2_k127_5289264_9	2903.EOD29480	4.755e-39	156.0	COG0652@1|root,KOG0885@2759|Eukaryota	2759|Eukaryota	O	peptidyl-prolyl cis-trans isomerase activity	CWC27	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005681,GO:0005684,GO:0005911,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009506,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030054,GO:0032991,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0055044,GO:0071012,GO:0071704,GO:0140096,GO:1901564,GO:1902494,GO:1990904	5.2.1.8	ko:K01802,ko:K12737	-	-	-	-	ko00000,ko01000,ko03041,ko03110	-	-	-	Pro_isomerase
DYD2_k127_5289264_8	84531.JMTZ01000014_gene2827	4.287e-45	185.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X8D9@135614|Xanthomonadales	135614|Xanthomonadales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
DYD2_k127_5296741_1	909613.UO65_3425	6.393e-22	111.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4DYXD@85010|Pseudonocardiales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_5296741_0	1120972.AUMH01000001_gene1042	1.545e-82	295.0	COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,4HBW3@91061|Bacilli,2791Y@186823|Alicyclobacillaceae	91061|Bacilli	S	ABC1 family	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
DYD2_k127_5314119_1	696747.NIES39_K03480	8.234e-46	179.0	COG4245@1|root,COG4245@2|Bacteria,1G913@1117|Cyanobacteria,1HGE2@1150|Oscillatoriales	1117|Cyanobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
DYD2_k127_5314119_2	485916.Dtox_2990	4.168e-20	100.0	COG0631@1|root,COG0631@2|Bacteria,1VSKQ@1239|Firmicutes	1239|Firmicutes	T	Protein phosphatase 2C	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
DYD2_k127_5314119_0	485916.Dtox_2989	5.652e-78	294.0	COG4248@1|root,COG4248@2|Bacteria,1UZ2E@1239|Firmicutes,24E7G@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
DYD2_k127_5314119_3	926550.CLDAP_07170	0.0003365	54.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
DYD2_k127_5323372_2	1116232.AHBF01000044_gene2878	2.483e-19	102.0	COG1994@1|root,COG1994@2|Bacteria,2I9PV@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5323372_0	1501230.ET33_18720	5.386e-51	193.0	COG2141@1|root,COG2141@2|Bacteria,1TPRS@1239|Firmicutes,4H9R2@91061|Bacilli,26QIZ@186822|Paenibacillaceae	91061|Bacilli	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_5323372_1	324057.Pjdr2_5360	2.58e-46	180.0	COG2141@1|root,COG2141@2|Bacteria,1TPRS@1239|Firmicutes,4H9R2@91061|Bacilli,26QIZ@186822|Paenibacillaceae	91061|Bacilli	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	ywcH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_5382225_4	2002.JOEQ01000013_gene5439	5.107e-12	66.0	2C3A2@1|root,2ZZP3@2|Bacteria,2I9BD@201174|Actinobacteria,4EJ3U@85012|Streptosporangiales	201174|Actinobacteria	S	PFAM DoxX family protein	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
DYD2_k127_5382225_2	1380347.JNII01000007_gene497	1.132e-19	103.0	2CBE1@1|root,32RT5@2|Bacteria,2IQDS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5382225_1	485916.Dtox_2727	1.775e-21	104.0	COG0622@1|root,COG0622@2|Bacteria,1W44P@1239|Firmicutes,257A9@186801|Clostridia	186801|Clostridia	S	Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5382225_3	521045.Kole_1260	1.252e-14	86.0	COG1409@1|root,COG1409@2|Bacteria,2GDAI@200918|Thermotogae	200918|Thermotogae	P	PFAM Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
DYD2_k127_5382225_5	926690.KE386573_gene1502	4.559e-09	65.0	arCOG03915@1|root,arCOG03915@2157|Archaea,2XZRQ@28890|Euryarchaeota,23XHM@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5382225_6	1197130.BAFM01000015_gene2535	1.5e-07	58.0	COG0640@1|root,arCOG03065@2157|Archaea,2Y0NA@28890|Euryarchaeota,23XRK@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_5382225_0	234267.Acid_5124	3.339e-27	116.0	2DKWS@1|root,30N64@2|Bacteria,3Y5WC@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4188
DYD2_k127_5404241_5	262724.TT_C0447	0.0008226	51.0	COG0287@1|root,COG0287@2|Bacteria,1WII2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	prephenate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	PDH
DYD2_k127_5404241_3	477641.MODMU_0965	1.688e-12	79.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ETCD@85013|Frankiales	201174|Actinobacteria	S	Laminin G domain	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
DYD2_k127_5404241_1	316274.Haur_3911	1.18e-76	273.0	COG2059@1|root,COG2059@2|Bacteria,2G6NB@200795|Chloroflexi,375VI@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
DYD2_k127_5404241_2	479434.Sthe_0634	3.493e-48	182.0	COG5483@1|root,COG5483@2|Bacteria,2G8NZ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
DYD2_k127_5404241_4	521011.Mpal_2425	5.778e-09	65.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota,2NBEM@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_5404241_0	1054217.TALC_01002	8.825e-90	310.0	COG0520@1|root,arCOG00065@2157|Archaea,2Y67Z@28890|Euryarchaeota,242FF@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
DYD2_k127_5421610_35	391625.PPSIR1_30913	6.45e-06	52.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,43AGY@68525|delta/epsilon subdivisions,2X5WX@28221|Deltaproteobacteria,2YWWR@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_12
DYD2_k127_5421610_21	469383.Cwoe_0799	1.464e-25	113.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,4CQBV@84995|Rubrobacteria	84995|Rubrobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
DYD2_k127_5421610_37	309803.CTN_0812	0.0002215	52.0	COG0639@1|root,COG0639@2|Bacteria,2GC5Q@200918|Thermotogae	200918|Thermotogae	T	Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
DYD2_k127_5421610_8	243232.MJ_1018	1.11e-89	306.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,23Q9F@183939|Methanococci	183939|Methanococci	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
DYD2_k127_5421610_9	1094980.Mpsy_1152	9.212e-83	291.0	COG0263@1|root,arCOG00864@2157|Archaea,2XV1I@28890|Euryarchaeota,2NAAX@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
DYD2_k127_5421610_7	296591.Bpro_3668	2.877e-97	327.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2VJSY@28216|Betaproteobacteria,4AC5T@80864|Comamonadaceae	28216|Betaproteobacteria	P	Membrane protein TerC	terC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,TerC
DYD2_k127_5421610_26	1120958.AULD01000010_gene2397	7.173e-19	99.0	COG0654@1|root,COG0654@2|Bacteria,2GK88@201174|Actinobacteria,4FN7M@85023|Microbacteriaceae	201174|Actinobacteria	CH	FAD binding domain	mhpA	-	1.14.13.127,1.14.13.219,1.14.13.220	ko:K05712,ko:K16022,ko:K20943,ko:K20944	ko00360,ko00362,ko01051,ko01052,ko01120,ko01220,map00360,map00362,map01051,map01052,map01120,map01220	M00545	R05249,R06786,R06787,R11347	RC00046,RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
DYD2_k127_5421610_29	1385513.N780_05310	2.557e-16	84.0	2CFXW@1|root,32WZK@2|Bacteria,1VB25@1239|Firmicutes,4HMPP@91061|Bacilli,2YAN3@289201|Pontibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5421610_31	743721.Psesu_1410	2.901e-10	68.0	COG4244@1|root,COG4244@2|Bacteria,1RF4K@1224|Proteobacteria,1S637@1236|Gammaproteobacteria,1X6NV@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
DYD2_k127_5421610_38	197221.22295735	0.0002323	52.0	COG1845@1|root,COG1845@2|Bacteria,1G02A@1117|Cyanobacteria	1117|Cyanobacteria	C	Heme copper-type cytochrome quinol oxidase subunit 3	ctaE	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
DYD2_k127_5421610_5	383372.Rcas_3557	3.584e-128	427.0	COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi,3750X@32061|Chloroflexia	32061|Chloroflexia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
DYD2_k127_5421610_20	469382.Hbor_15730	3.274e-31	140.0	COG1622@1|root,arCOG01235@2157|Archaea,2XURX@28890|Euryarchaeota,23S69@183963|Halobacteria	183963|Halobacteria	C	COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2	coxB4	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
DYD2_k127_5421610_34	1463901.JOIY01000008_gene2849	1.084e-06	61.0	COG4244@1|root,COG4244@2|Bacteria,2II9W@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
DYD2_k127_5421610_4	869210.Marky_1941	1.936e-145	482.0	COG3387@1|root,COG3387@2|Bacteria,1WM7G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
DYD2_k127_5421610_11	1449126.JQKL01000047_gene2728	4.775e-76	272.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,268PP@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
DYD2_k127_5421610_0	1459636.NTE_01425	9.54e-215	685.0	COG0028@1|root,arCOG01999@2157|Archaea	2157|Archaea	C	Belongs to the TPP enzyme family	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	Rubredoxin,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
DYD2_k127_5421610_1	1187851.A33M_3952	3.185e-169	560.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,3FDZ1@34008|Rhodovulum	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
DYD2_k127_5421610_6	1168059.KB899087_gene2935	1.637e-111	374.0	COG2141@1|root,COG2141@2|Bacteria,1MXQU@1224|Proteobacteria,2U1X1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_5421610_10	1341151.ASZU01000010_gene1848	6.875e-80	284.0	COG3424@1|root,COG3424@2|Bacteria,1TPUK@1239|Firmicutes,4HBHH@91061|Bacilli,27B3Q@186824|Thermoactinomycetaceae	91061|Bacilli	Q	Chalcone and stilbene synthases, N-terminal domain	bcsA	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
DYD2_k127_5421610_28	1448139.AI20_13930	1.91e-16	86.0	COG1384@1|root,COG3454@1|root,COG1384@2|Bacteria,COG3454@2|Bacteria,1R33M@1224|Proteobacteria,1T62P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Domain of unknown function (DUF4209)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4209
DYD2_k127_5421610_39	269797.Mbar_A2247	0.000451	53.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,2NA4B@224756|Methanomicrobia	224756|Methanomicrobia	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
DYD2_k127_5421610_23	397945.Aave_0091	2.295e-23	100.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2VP2D@28216|Betaproteobacteria,4AEEG@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
DYD2_k127_5421610_16	1336208.JADY01000012_gene3000	1.007e-55	198.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2U1DA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
DYD2_k127_5421610_33	192952.MM_2114	6.726e-08	64.0	arCOG06532@1|root,arCOG06532@2157|Archaea,2Y12Z@28890|Euryarchaeota,2NA6P@224756|Methanomicrobia	224756|Methanomicrobia	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
DYD2_k127_5421610_3	59538.XP_005984947.1	7.595e-167	554.0	COG0753@1|root,KOG0047@2759|Eukaryota,38BMC@33154|Opisthokonta,3BFAV@33208|Metazoa,3CSMT@33213|Bilateria,48809@7711|Chordata,48VHW@7742|Vertebrata,3JAIA@40674|Mammalia,4J389@91561|Cetartiodactyla	33208|Metazoa	P	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
DYD2_k127_5421610_13	484770.UFO1_3359	9.013e-70	249.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_1,Big_3_2,Big_5,DUF11,DUF3494
DYD2_k127_5421610_32	641112.ACOK01000074_gene3081	2.231e-08	62.0	COG0330@1|root,COG0330@2|Bacteria,1UZJK@1239|Firmicutes,24IK1@186801|Clostridia,3WHEQ@541000|Ruminococcaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DYD2_k127_5421610_12	523841.HFX_1415	9.286e-71	258.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,23RXQ@183963|Halobacteria	183963|Halobacteria	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa1	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
DYD2_k127_5421610_17	351160.LRC265	1.918e-46	192.0	COG3390@1|root,arCOG02258@2157|Archaea,2XT3R@28890|Euryarchaeota,2N9P2@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_5421610_27	439481.Aboo_0564	1.933e-17	83.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,3F2VM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
DYD2_k127_5421610_25	439481.Aboo_0565	1.81e-19	98.0	COG2004@1|root,arCOG04182@2157|Archaea,2Y6EY@28890|Euryarchaeota,3F2VW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
DYD2_k127_5421610_22	485914.Hmuk_0726	1.794e-25	122.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,23W2W@183963|Halobacteria	183963|Halobacteria	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
DYD2_k127_5421610_30	1230457.C476_06672	1.956e-15	77.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,23XKI@183963|Halobacteria	183963|Halobacteria	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
DYD2_k127_5421610_15	1236689.MMALV_04370	1.436e-64	229.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,3F2MN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	rpoE1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
DYD2_k127_5421610_19	398767.Glov_1411	1.928e-34	145.0	COG3613@1|root,COG3613@2|Bacteria,1RKN9@1224|Proteobacteria,42WY0@68525|delta/epsilon subdivisions,2WTEI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5421610_36	1455608.JDTH01000002_gene645	6.632e-05	53.0	COG0433@1|root,arCOG06224@2157|Archaea,2Y281@28890|Euryarchaeota,23YSU@183963|Halobacteria	183963|Halobacteria	L	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5421610_2	1094980.Mpsy_0967	4.972e-167	535.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
DYD2_k127_5421610_24	1123368.AUIS01000003_gene1707	2.678e-23	115.0	COG2202@1|root,COG3614@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3614@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria,2NDJ6@225057|Acidithiobacillales	1236|Gammaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd
DYD2_k127_5421610_18	1079460.ATTQ01000028_gene4646	3.624e-35	154.0	COG1807@1|root,COG3829@1|root,COG4251@1|root,COG1807@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2UR9Y@28211|Alphaproteobacteria,4BNTR@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
DYD2_k127_5421610_14	1123405.AUMM01000004_gene701	4.324e-67	230.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,26NC6@186821|Sporolactobacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	mmgB	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_5440482_3	641524.ADICYQ_2480	1.976e-15	85.0	COG1913@1|root,COG1913@2|Bacteria,4NJFJ@976|Bacteroidetes,47Q85@768503|Cytophagia	976|Bacteroidetes	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
DYD2_k127_5440482_1	1033802.SSPSH_002148	2.32e-40	158.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
DYD2_k127_5440482_2	926560.KE387023_gene2455	8.239e-23	107.0	2E8MZ@1|root,332ZD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5440482_0	1379698.RBG1_1C00001G0806	1.511e-43	161.0	COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_5443151_0	673860.AciM339_1561	2.093e-108	380.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,3F2FZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Toprim domain	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
DYD2_k127_5443151_6	304371.MCP_0111	5.855e-21	98.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,2N9YJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
DYD2_k127_5443151_11	699218.HMPREF0889_0624	0.0002108	54.0	COG1807@1|root,COG1807@2|Bacteria,1TR2V@1239|Firmicutes,4H2B5@909932|Negativicutes	909932|Negativicutes	M	dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
DYD2_k127_5443151_1	439481.Aboo_0935	6.453e-60	228.0	COG0668@1|root,arCOG01568@2157|Archaea,2XUW2@28890|Euryarchaeota,3F2R0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Mechanosensitive ion channel	-	-	-	ko:K03442,ko:K05802,ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.2,1.A.23.4	-	-	MS_channel
DYD2_k127_5443151_4	1206741.BAFX01000084_gene6270	6.675e-22	110.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5443151_7	203119.Cthe_1235	2.444e-11	77.0	COG1470@1|root,COG2373@1|root,COG2931@1|root,COG2982@1|root,COG3210@1|root,COG3291@1|root,COG3391@1|root,COG3979@1|root,COG4733@1|root,COG5520@1|root,COG1470@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3979@2|Bacteria,COG4733@2|Bacteria,COG5520@2|Bacteria,1TQ2T@1239|Firmicutes,24EP0@186801|Clostridia,3WI1H@541000|Ruminococcaceae	186801|Clostridia	MU	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD,Paired_CXXCH_1,SLH,fn3
DYD2_k127_5443151_9	342113.DM82_5774	1.77e-07	58.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,2VIT3@28216|Betaproteobacteria,1K5CY@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
DYD2_k127_5443151_2	243231.GSU2567	1.145e-59	224.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,MASE3,PAS_3,PAS_4,PAS_9,dCache_1
DYD2_k127_5443151_3	349520.PPE_03161	5.268e-46	183.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,26R7Y@186822|Paenibacillaceae	91061|Bacilli	O	Belongs to the peptidase S8 family	apr	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_5443151_5	1227453.C444_12697	1.787e-21	102.0	COG0500@1|root,arCOG04583@2157|Archaea,2XTVC@28890|Euryarchaeota,23ST5@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DYD2_k127_5443151_8	1333998.M2A_1697	4.811e-09	67.0	COG2050@1|root,COG2050@2|Bacteria,1NA0B@1224|Proteobacteria,2UI6H@28211|Alphaproteobacteria,4BR2F@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_5443151_10	694430.Natoc_3746	3.198e-06	58.0	arCOG04714@1|root,arCOG04714@2157|Archaea,2XXWQ@28890|Euryarchaeota,23WMN@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5453727_2	698757.Pogu_0973	1.656e-101	363.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
DYD2_k127_5453727_0	1267534.KB906759_gene1728	1.59e-149	493.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
DYD2_k127_5484190_5	797302.Halru_1910	3.569e-05	56.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_5484190_2	351160.LRC28	3.311e-46	184.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2N9MV@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
DYD2_k127_5484190_0	861299.J421_1999	2.034e-153	506.0	COG2312@1|root,COG2312@2|Bacteria	2|Bacteria	S	response to antibiotic	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT
DYD2_k127_5484190_1	448385.sce9042	1.511e-126	421.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,1RDAY@1224|Proteobacteria,43CWS@68525|delta/epsilon subdivisions,2X84R@28221|Deltaproteobacteria,2YX1U@29|Myxococcales	28221|Deltaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
DYD2_k127_5484190_4	935565.JAEM01000071_gene726	1.622e-05	55.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria,2PWJS@265|Paracoccus	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_5484190_3	868131.MSWAN_2280	2.329e-11	74.0	COG1051@1|root,arCOG01075@2157|Archaea,2XZGP@28890|Euryarchaeota,23PPE@183925|Methanobacteria	183925|Methanobacteria	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
DYD2_k127_5509594_6	395495.Lcho_3739	2.107e-05	57.0	COG0689@1|root,COG5276@1|root,COG0689@2|Bacteria,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria	1224|Proteobacteria	N	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,He_PIG,LVIVD
DYD2_k127_5509594_4	292459.STH173	2.316e-14	85.0	COG0526@1|root,COG0682@1|root,COG0526@2|Bacteria,COG0682@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia	186801|Clostridia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
DYD2_k127_5509594_3	269797.Mbar_A3229	7.054e-44	167.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
DYD2_k127_5509594_1	1230457.C476_10571	1.223e-64	231.0	COG2301@1|root,arCOG00760@2157|Archaea,2XUK3@28890|Euryarchaeota,23S1V@183963|Halobacteria	183963|Halobacteria	G	COG2301 Citrate lyase beta subunit	citE	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
DYD2_k127_5509594_5	1123277.KB893239_gene1249	8.221e-11	74.0	2DPXN@1|root,333U2@2|Bacteria,4NWCD@976|Bacteroidetes,47SBV@768503|Cytophagia	976|Bacteroidetes	S	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
DYD2_k127_5509594_2	1205680.CAKO01000010_gene3817	2.538e-44	168.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2U7FW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
DYD2_k127_5509594_0	102129.Lepto7375DRAFT_1471	8.185e-77	289.0	COG3540@1|root,COG3540@2|Bacteria,1G27Q@1117|Cyanobacteria,1H9KJ@1150|Oscillatoriales	1117|Cyanobacteria	P	PFAM PhoD-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5546253_2	158822.LH89_07620	8.195e-07	57.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,1S91M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
DYD2_k127_5546253_1	562970.Btus_1400	1.275e-25	113.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
DYD2_k127_5546253_0	309800.C498_13809	1.052e-79	274.0	COG1475@1|root,arCOG00622@2157|Archaea,2XTYJ@28890|Euryarchaeota,23S7H@183963|Halobacteria	183963|Halobacteria	K	COG0517 FOG CBS domain	cbs10	-	-	-	-	-	-	-	-	-	-	-	CBS,ParBc
DYD2_k127_5641596_5	1236689.MMALV_10880	6.34e-57	212.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,3F2N3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Amidohydrolase family	guaD2	-	3.5.4.1,3.5.4.3	ko:K01485,ko:K01487	ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100	-	R00974,R01411,R01676,R02922	RC00074,RC00204,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
DYD2_k127_5641596_22	797210.Halxa_0818	2.599e-05	55.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_5641596_15	251229.Chro_0322	3.86e-23	112.0	28JN3@1|root,2Z9EI@2|Bacteria,1G4B8@1117|Cyanobacteria,3VNH5@52604|Pleurocapsales	1117|Cyanobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
DYD2_k127_5641596_4	251221.35211043	1.618e-66	238.0	COG0451@1|root,COG0451@2|Bacteria,1G48F@1117|Cyanobacteria	1117|Cyanobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
DYD2_k127_5641596_10	290397.Adeh_3195	7.448e-28	117.0	COG5649@1|root,COG5649@2|Bacteria,1RDDG@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DYD2_k127_5641596_8	1054217.TALC_00518	4.776e-45	175.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,241MU@183967|Thermoplasmata	183967|Thermoplasmata	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
DYD2_k127_5641596_3	1123242.JH636435_gene2634	4.459e-89	303.0	COG0656@1|root,COG0656@2|Bacteria,2IWVI@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Aldo keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
DYD2_k127_5641596_18	391937.NA2_16198	1.217e-15	87.0	COG5470@1|root,COG5470@2|Bacteria,1MZDP@1224|Proteobacteria,2UDUR@28211|Alphaproteobacteria,43Q25@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
DYD2_k127_5641596_13	69395.JQLZ01000006_gene2054	4.366e-25	124.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,2UJHW@28211|Alphaproteobacteria,2KJ5I@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
DYD2_k127_5641596_6	1254432.SCE1572_16710	3.315e-54	202.0	COG0500@1|root,COG2226@2|Bacteria,1QXUA@1224|Proteobacteria,42QNQ@68525|delta/epsilon subdivisions,2WMN4@28221|Deltaproteobacteria,2Z09Z@29|Myxococcales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DYD2_k127_5641596_17	1121272.KB903290_gene4733	4.003e-16	79.0	2EMYX@1|root,33FM2@2|Bacteria,2GZ6D@201174|Actinobacteria,4DKE1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5641596_2	1455608.JDTH01000011_gene2341	3e-95	322.0	COG0031@1|root,arCOG01430@2157|Archaea,2Y2Y8@28890|Euryarchaeota,23Z1R@183963|Halobacteria	183963|Halobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
DYD2_k127_5641596_9	404589.Anae109_2147	4.559e-43	181.0	COG2128@1|root,COG2128@2|Bacteria,1RDRU@1224|Proteobacteria,4311A@68525|delta/epsilon subdivisions,2WWGN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	ahpD	-	-	ko:K04756	-	-	-	-	ko00000	-	-	-	CMD
DYD2_k127_5641596_7	1207063.P24_08489	2.109e-49	180.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,2TV43@28211|Alphaproteobacteria,2JPJ8@204441|Rhodospirillales	204441|Rhodospirillales	O	Peroxiredoxin	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
DYD2_k127_5641596_16	882083.SacmaDRAFT_2803	6.103e-23	107.0	2FDI0@1|root,345JG@2|Bacteria,2IPSA@201174|Actinobacteria,4E4AZ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
DYD2_k127_5641596_1	1157708.KB907460_gene1359	4.822e-97	329.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,4AC1Z@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Methyltransferase type 11	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
DYD2_k127_5641596_23	1313304.CALK_0539	0.0005955	49.0	2DMID@1|root,32RSF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii,DUF2204
DYD2_k127_5641596_19	99598.Cal7507_1315	6.1e-12	68.0	COG4096@1|root,COG4096@2|Bacteria,1G3A8@1117|Cyanobacteria,1HQSE@1161|Nostocales	1117|Cyanobacteria	V	COGs COG4096 Type I site-specific restriction-modification system R (restriction) subunit and related helicase	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF4145,EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
DYD2_k127_5641596_20	192952.MM_1772	1.167e-08	64.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
DYD2_k127_5641596_21	1385521.N803_05380	5.165e-06	60.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria,4FFRU@85021|Intrasporangiaceae	201174|Actinobacteria	S	with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF676,PGAP1
DYD2_k127_5641596_12	589924.Ferp_0438	1.107e-25	111.0	COG2361@1|root,arCOG05024@2157|Archaea,2Y6HF@28890|Euryarchaeota,246HB@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
DYD2_k127_5641596_11	765420.OSCT_1110	8.615e-26	111.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
DYD2_k127_5641596_0	1054217.TALC_00031	6.147e-166	526.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,241JU@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbA	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
DYD2_k127_5689314_2	406552.NJ7G_2697	7.892e-57	219.0	COG1404@1|root,COG3979@1|root,arCOG00702@2157|Archaea,arCOG07581@2157|Archaea,2XSZR@28890|Euryarchaeota,23U34@183963|Halobacteria	183963|Halobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.62	ko:K01342,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
DYD2_k127_5689314_1	1094980.Mpsy_2247	2.673e-218	699.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
DYD2_k127_5689314_4	1206741.BAFX01000084_gene6270	1.857e-15	90.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5689314_6	1049564.TevJSym_aa01840	0.0001577	50.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	zraR	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
DYD2_k127_5689314_5	69014.TK0632	4.354e-09	64.0	COG0784@1|root,arCOG02391@2157|Archaea,2XXBY@28890|Euryarchaeota,2449F@183968|Thermococci	183968|Thermococci	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
DYD2_k127_5689314_3	1054217.TALC_00224	2.499e-19	99.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,241TG@183967|Thermoplasmata	183967|Thermoplasmata	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
DYD2_k127_5689314_0	1122919.KB905612_gene349	1.521e-253	797.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H9Y6@91061|Bacilli,26R74@186822|Paenibacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
DYD2_k127_5721134_10	395493.BegalDRAFT_0256	0.0003357	54.0	COG1075@1|root,COG1075@2|Bacteria,1P60C@1224|Proteobacteria	1224|Proteobacteria	N	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
DYD2_k127_5721134_4	1042877.GQS_09595	4.669e-23	117.0	COG5650@1|root,arCOG06688@2157|Archaea,2Y6NP@28890|Euryarchaeota,244YK@183968|Thermococci	183968|Thermococci	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
DYD2_k127_5721134_7	521045.Kole_0482	1.848e-11	79.0	COG3103@1|root,COG4991@2|Bacteria	2|Bacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SH3_3
DYD2_k127_5721134_6	436229.JOEH01000027_gene2181	2.035e-19	104.0	COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria,2NFT0@228398|Streptacidiphilus	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2,PMT_2
DYD2_k127_5721134_2	391623.TERMP_01739	2.373e-48	188.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
DYD2_k127_5721134_8	1210908.HSB1_16280	4.13e-05	56.0	COG5276@1|root,arCOG02565@2157|Archaea,2XV6J@28890|Euryarchaeota,23SNQ@183963|Halobacteria	183963|Halobacteria	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_5721134_1	580327.Tthe_1658	2.677e-66	248.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,42FKR@68295|Thermoanaerobacterales	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
DYD2_k127_5721134_3	1511.CLOST_1136	5.674e-46	176.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,25R6D@186804|Peptostreptococcaceae	186801|Clostridia	C	Electron transfer	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
DYD2_k127_5721134_9	368407.Memar_0091	5.266e-05	54.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_5721134_0	867845.KI911784_gene1118	2.256e-96	332.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi,374SC@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_57241_2	797302.Halru_1149	1.456e-08	67.0	COG3979@1|root,COG5276@1|root,arCOG02565@2157|Archaea,arCOG07581@2157|Archaea,2XV6J@28890|Euryarchaeota,23SNQ@183963|Halobacteria	183963|Halobacteria	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_57241_0	439481.Aboo_0348	2.779e-56	204.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,3F2KA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
DYD2_k127_57241_1	1324957.K933_14333	1.567e-15	81.0	COG1184@1|root,arCOG01127@2157|Archaea,2XUMH@28890|Euryarchaeota,23SF4@183963|Halobacteria	183963|Halobacteria	J	Belongs to the eIF-2B alpha beta delta subunits family	tif2Ba	-	-	-	-	-	-	-	-	-	-	-	IF-2B,NUDIX
DYD2_k127_5740365_2	589924.Ferp_0823	1.738e-06	58.0	COG1745@1|root,arCOG02254@2157|Archaea,2Y7DF@28890|Euryarchaeota,247A1@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0058	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
DYD2_k127_5740365_1	926569.ANT_16930	1.21e-51	198.0	COG2234@1|root,COG2234@2|Bacteria,2G6WJ@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
DYD2_k127_5740365_0	679926.Mpet_2131	1.747e-102	340.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,2N926@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin,tRNA_deacylase
DYD2_k127_5741449_0	868131.MSWAN_1886	2.441e-145	492.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,23NQB@183925|Methanobacteria	183925|Methanobacteria	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
DYD2_k127_5741449_8	1150864.MILUP08_41178	5.188e-06	57.0	COG3440@1|root,COG3440@2|Bacteria,2IJU1@201174|Actinobacteria	201174|Actinobacteria	V	HNH endonuclease	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
DYD2_k127_5741449_9	456442.Mboo_2172	1.016e-05	52.0	arCOG11029@1|root,arCOG11029@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5741449_4	443144.GM21_2071	3.714e-39	160.0	COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria	1224|Proteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
DYD2_k127_5741449_5	136037.KDR14581	6.015e-23	113.0	COG2866@1|root,KOG2650@2759|Eukaryota,38DUK@33154|Opisthokonta,3BA6U@33208|Metazoa,3CUQS@33213|Bilateria,41TMX@6656|Arthropoda,3SK4E@50557|Insecta	33208|Metazoa	O	Zn_pept	-	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044421,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	Peptidase_M14,Propep_M14,ShK
DYD2_k127_5741449_7	797210.Halxa_2723	8.643e-07	60.0	arCOG01172@1|root,arCOG01172@2157|Archaea,2XTWD@28890|Euryarchaeota,23U9K@183963|Halobacteria	183963|Halobacteria	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	htlC	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_5741449_3	351160.RCIX112	1.213e-56	220.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2N93G@224756|Methanomicrobia	224756|Methanomicrobia	N	type II secretion system protein	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DYD2_k127_5741449_1	351160.RCIX2217	3.404e-139	466.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DYD2_k127_5741449_2	697303.Thewi_0615	3.304e-62	226.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_5741449_6	387631.Asulf_02173	7.897e-08	64.0	COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota	28890|Euryarchaeota	L	integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
DYD2_k127_5800637_0	309807.SRU_0802	5.798e-15	86.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes	976|Bacteroidetes	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DYD2_k127_5800637_1	595460.RRSWK_07188	6.992e-14	84.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	HEAT_2,Peptidase_M9,Peptidase_M9_N
DYD2_k127_5808936_1	198094.BA_2793	1.985e-10	77.0	COG3397@1|root,COG3979@1|root,COG3397@2|Bacteria,COG3979@2|Bacteria,1V9FX@1239|Firmicutes,4HK49@91061|Bacilli,1ZKFD@1386|Bacillus	91061|Bacilli	S	Fibronectin type III domain protein	-	-	-	ko:K03933	-	-	-	-	ko00000	-	AA10,CBM73	-	LPMO_10,fn3
DYD2_k127_5808936_0	634497.HAH_1629	1.868e-14	87.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,23SFQ@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
DYD2_k127_5808936_2	186497.PF2013	4.28e-06	59.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,245AN@183968|Thermococci	183968|Thermococci	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
DYD2_k127_5980899_4	246197.MXAN_7035	9.26e-14	79.0	COG2068@1|root,COG2068@2|Bacteria	2|Bacteria	NU	MobA-Related Protein	nboR	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
DYD2_k127_5980899_3	1054217.TALC_00273	5.742e-32	136.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,241QE@183967|Thermoplasmata	183967|Thermoplasmata	H	UbiA prenyltransferase family	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
DYD2_k127_5980899_0	439481.Aboo_0770	8.187e-67	237.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,3F2M3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
DYD2_k127_5980899_1	1463825.JNXC01000028_gene135	1.348e-51	201.0	COG1073@1|root,COG1073@2|Bacteria,2ID35@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S15
DYD2_k127_5980899_2	365046.Rta_11450	2.077e-47	175.0	COG2755@1|root,COG2755@2|Bacteria,1NT43@1224|Proteobacteria,2W04A@28216|Betaproteobacteria	28216|Betaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6015676_5	439481.Aboo_0790	2.079e-65	231.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
DYD2_k127_6015676_4	439481.Aboo_0908	2.63e-71	246.0	COG1859@1|root,arCOG04063@2157|Archaea,2XWPC@28890|Euryarchaeota,3F2KG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
DYD2_k127_6015676_2	265729.GS18_0210230	2.976e-112	413.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,1ZB7V@1386|Bacillus	91061|Bacilli	I	Belongs to the thiolase family	atoB	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iYO844.BSU24170	Thiolase_C,Thiolase_N
DYD2_k127_6015676_1	1121405.dsmv_3828	8.643e-125	426.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MJ1A@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM 3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157,1.1.1.35,4.2.1.17	ko:K00074,ko:K15016	ko00360,ko00362,ko00650,ko00720,ko01100,ko01120,ko01200,map00360,map00362,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R01975,R01976,R03026,R05576,R06941	RC00029,RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N
DYD2_k127_6015676_3	930169.B5T_00157	2.901e-82	296.0	COG4188@1|root,COG4188@2|Bacteria,1Q4K6@1224|Proteobacteria,1S7GC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6015676_8	448385.sce8046	1.59e-27	125.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,42R1V@68525|delta/epsilon subdivisions,2WN7S@28221|Deltaproteobacteria,2YVUM@29|Myxococcales	28221|Deltaproteobacteria	K	zinc metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
DYD2_k127_6015676_0	926560.KE387023_gene1701	6.175e-177	583.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF3365,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_6015676_6	867903.ThesuDRAFT_02179	5.648e-51	192.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,3WDJP@538999|Clostridiales incertae sedis	186801|Clostridia	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S9
DYD2_k127_6015676_7	1151117.AJLF01000001_gene1054	3.716e-36	153.0	COG1073@1|root,arCOG01651@2157|Archaea,2XUHY@28890|Euryarchaeota,2430A@183968|Thermococci	183968|Thermococci	S	Alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Peptidase_S15
DYD2_k127_602476_4	404589.Anae109_1389	2.706e-65	241.0	COG1251@1|root,COG3383@1|root,COG1251@2|Bacteria,COG3383@2|Bacteria,1QXVG@1224|Proteobacteria	1224|Proteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Pyr_redox_2
DYD2_k127_602476_12	589924.Ferp_2558	2.26e-16	89.0	COG0446@1|root,arCOG05745@2157|Archaea,2XZPN@28890|Euryarchaeota,246DF@183980|Archaeoglobi	183980|Archaeoglobi	C	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
DYD2_k127_602476_2	1278073.MYSTI_03953	2.029e-118	398.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria,2YUM5@29|Myxococcales	28221|Deltaproteobacteria	E	Sarcosine oxidase	soxB	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
DYD2_k127_602476_15	1047013.AQSP01000066_gene724	1.312e-08	58.0	2E5PY@1|root,330EK@2|Bacteria,2NS29@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_602476_10	523850.TON_1230	1.224e-18	86.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,244GA@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
DYD2_k127_602476_5	523845.AQXV01000052_gene562	1.646e-55	203.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,23Q9J@183939|Methanococci	183939|Methanococci	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
DYD2_k127_602476_7	673860.AciM339_0317	2.287e-41	157.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,3F2RF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
DYD2_k127_602476_8	439481.Aboo_0746	1.004e-39	161.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,3F2K2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	6,7-dimethyl-8-ribityllumazine synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
DYD2_k127_602476_6	868131.MSWAN_2310	1.879e-41	167.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,23P08@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
DYD2_k127_602476_1	387631.Asulf_01433	2.442e-144	491.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,245SW@183980|Archaeoglobi	183980|Archaeoglobi	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
DYD2_k127_602476_14	648757.Rvan_0043	3.119e-11	71.0	COG0454@1|root,COG0456@2|Bacteria,1N43K@1224|Proteobacteria,2UDB6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_602476_11	479432.Sros_6147	1.232e-18	100.0	COG5276@1|root,COG5276@2|Bacteria,2IDWW@201174|Actinobacteria,4EH21@85012|Streptosporangiales	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_602476_0	383372.Rcas_3184	2.653e-162	532.0	COG3975@1|root,COG3975@2|Bacteria,2GAB7@200795|Chloroflexi,374W2@32061|Chloroflexia	32061|Chloroflexia	S	SMART PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
DYD2_k127_602476_3	439481.Aboo_1323	1.228e-85	299.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,3F2JQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
DYD2_k127_602476_9	673860.AciM339_0341	2.489e-37	151.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2MV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
DYD2_k127_602476_13	1146883.BLASA_0806	1.458e-15	87.0	COG0398@1|root,COG0398@2|Bacteria,2GN68@201174|Actinobacteria	201174|Actinobacteria	S	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
DYD2_k127_6033444_4	196162.Noca_1475	2.772e-29	128.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria,4DTXA@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6033444_9	1298863.AUEP01000001_gene909	1.151e-14	84.0	COG1629@1|root,COG2730@1|root,COG3509@1|root,COG2730@2|Bacteria,COG3509@2|Bacteria,COG4771@2|Bacteria,2I7I0@201174|Actinobacteria	201174|Actinobacteria	G	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6033444_0	717605.Theco_1742	0.0	1437.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,4HBER@91061|Bacilli,26T6P@186822|Paenibacillaceae	91061|Bacilli	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
DYD2_k127_6033444_3	1094980.Mpsy_1816	6.946e-32	139.0	COG0685@1|root,arCOG00475@2157|Archaea,2XZYB@28890|Euryarchaeota,2NACU@224756|Methanomicrobia	224756|Methanomicrobia	E	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
DYD2_k127_6033444_1	292459.STH118	4.576e-158	507.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
DYD2_k127_6033444_10	479435.Kfla_5389	7.142e-07	59.0	COG3664@1|root,COG3664@2|Bacteria,2GNYC@201174|Actinobacteria,4DRJ5@85009|Propionibacteriales	201174|Actinobacteria	G	Glycosyl hydrolases family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	F5_F8_type_C,Glyco_hydro_39
DYD2_k127_6033444_2	903818.KI912268_gene776	9.655e-105	360.0	2EZBF@1|root,33SGT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6033444_5	309800.C498_12873	2.514e-27	117.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,23SHC@183963|Halobacteria	183963|Halobacteria	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
DYD2_k127_6033444_7	913325.N799_13835	8.096e-19	100.0	COG4430@1|root,COG4430@2|Bacteria,1N8ME@1224|Proteobacteria,1T0U8@1236|Gammaproteobacteria,1XD1S@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
DYD2_k127_6033444_6	1197130.BAFM01000032_gene3199	3.886e-23	114.0	COG1651@1|root,COG2116@1|root,arCOG02868@2157|Archaea,arCOG03454@2157|Archaea,2XW8R@28890|Euryarchaeota,23U3Q@183963|Halobacteria	183963|Halobacteria	OP	DSBA-like thioredoxin domain	-	-	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans,Thioredoxin_4
DYD2_k127_6033444_8	573061.Clocel_0140	9.134e-19	102.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PKD,REJ,VWA_2
DYD2_k127_6047849_1	383372.Rcas_3059	2.952e-51	190.0	COG1131@1|root,COG1131@2|Bacteria,2GAQH@200795|Chloroflexi,3753M@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
DYD2_k127_6047849_2	113395.AXAI01000021_gene3448	4.862e-37	150.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,3K0QI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
DYD2_k127_6047849_0	926550.CLDAP_20120	1.616e-131	459.0	COG0514@1|root,COG4783@1|root,COG0514@2|Bacteria,COG4783@2|Bacteria,2G6QT@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DEAD DEAH box helicase domain protein	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
DYD2_k127_6053912_2	1197130.BAFM01000014_gene2400	1.75e-51	192.0	COG0846@1|root,arCOG04248@2157|Archaea,2XT4V@28890|Euryarchaeota,23T23@183963|Halobacteria	183963|Halobacteria	K	COG0846 NAD-dependent protein deacetylases, SIR2 family	sir2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
DYD2_k127_6053912_0	1121920.AUAU01000013_gene1702	2.048e-110	392.0	COG0014@1|root,COG0014@2|Bacteria,3Y48U@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
DYD2_k127_6053912_3	1041930.Mtc_2351	9.603e-13	79.0	COG1531@1|root,arCOG01302@2157|Archaea	2157|Archaea	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
DYD2_k127_6053912_1	1094980.Mpsy_2707	7.195e-98	337.0	COG0463@1|root,arCOG04794@2157|Archaea,2XTE3@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	gtl5	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
DYD2_k127_6057197_5	1227739.Hsw_2115	1.997e-16	89.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	HTH_7,Recombinase,Resolvase
DYD2_k127_6057197_10	697281.Mahau_1117	2.399e-07	63.0	COG4733@1|root,COG4733@2|Bacteria,1TSA1@1239|Firmicutes,24AA9@186801|Clostridia	186801|Clostridia	M	hydrolase, family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_3,Dockerin_1,Glyco_hydro_9
DYD2_k127_6057197_7	1150399.AQYK01000002_gene3209	3.285e-11	75.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
DYD2_k127_6057197_3	219305.MCAG_03850	4.709e-51	188.0	2E4SN@1|root,32ZM3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6057197_2	401053.AciPR4_3094	4.849e-54	202.0	COG0270@1|root,COG0270@2|Bacteria,3Y5V5@57723|Acidobacteria,2JNSG@204432|Acidobacteriia	204432|Acidobacteriia	L	C-5 cytosine-specific DNA methylase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
DYD2_k127_6057197_8	693661.Arcve_0149	1.64e-08	66.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_6057197_0	673860.AciM339_0726	2.619e-59	219.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,3F2H6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eIF-2B alpha beta delta subunits family	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
DYD2_k127_6057197_9	1167006.UWK_02202	1.745e-08	64.0	COG0484@1|root,COG4103@1|root,COG0484@2|Bacteria,COG4103@2|Bacteria,1QWQ7@1224|Proteobacteria,43BV3@68525|delta/epsilon subdivisions,2X762@28221|Deltaproteobacteria,2MPKT@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tellurite resistance protein TerB	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
DYD2_k127_6057197_6	673860.AciM339_0167	1.458e-12	75.0	arCOG05345@1|root,arCOG05345@2157|Archaea,2Y117@28890|Euryarchaeota,3F3G9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6057197_4	572478.Vdis_1970	9.47e-45	173.0	COG2086@1|root,arCOG00446@2157|Archaea,2XS2H@28889|Crenarchaeota	28889|Crenarchaeota	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
DYD2_k127_6057197_1	335543.Sfum_3929	1.013e-55	218.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	iAF987.Gmet_2257	ETF,ETF_alpha
DYD2_k127_605935_1	1463920.JOGB01000088_gene6351	1.339e-13	80.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria	201174|Actinobacteria	H	PFAM thiamineS protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
DYD2_k127_605935_0	1463854.JOHT01000009_gene1285	3.511e-106	356.0	COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria	201174|Actinobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR_6
DYD2_k127_6103816_2	693661.Arcve_1228	4.793e-82	306.0	COG0277@1|root,arCOG00340@2157|Archaea,2XVP5@28890|Euryarchaeota	28890|Euryarchaeota	C	FAD binding domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
DYD2_k127_6103816_9	1070774.J07HN4v3_02274	4.11e-13	72.0	arCOG04596@1|root,arCOG04596@2157|Archaea,2XX20@28890|Euryarchaeota,23VPS@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6103816_7	751944.HALDL1_07045	2.78e-22	107.0	COG0723@1|root,arCOG04595@2157|Archaea,2XU6P@28890|Euryarchaeota,23SAN@183963|Halobacteria	183963|Halobacteria	C	COG0723 Rieske Fe-S protein	petA	-	-	-	-	-	-	-	-	-	-	-	Rieske
DYD2_k127_6103816_3	1071085.KK033114_gene683	4.382e-78	270.0	COG1290@1|root,arCOG01721@2157|Archaea,2XUQH@28890|Euryarchaeota,23TXF@183963|Halobacteria	183963|Halobacteria	C	COG1290 Cytochrome b subunit of the bc complex	petB	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B
DYD2_k127_6103816_6	523841.HFX_0774	8.137e-28	125.0	COG1290@1|root,arCOG04594@2157|Archaea,2XUW1@28890|Euryarchaeota,23S8Q@183963|Halobacteria	183963|Halobacteria	C	COG1290 Cytochrome b subunit of the bc complex	petD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
DYD2_k127_6103816_11	1449068.JMLQ01000010_gene3870	0.0002171	55.0	COG5295@1|root,COG5295@2|Bacteria,2IPIA@201174|Actinobacteria,4FV5S@85025|Nocardiaceae	201174|Actinobacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6103816_8	1121935.AQXX01000139_gene3000	3.503e-16	88.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S2RH@1236|Gammaproteobacteria,1XJB0@135619|Oceanospirillales	135619|Oceanospirillales	T	Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
DYD2_k127_6103816_0	1343739.PAP_02800	8.777e-188	598.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
DYD2_k127_6103816_4	644966.Tmar_1718	3.012e-64	230.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes,247XS@186801|Clostridia	186801|Clostridia	IQ	Dehydrogenase	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DYD2_k127_6103816_1	1278073.MYSTI_03111	8.358e-96	336.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria,2YUTG@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
DYD2_k127_6103816_5	765698.Mesci_4680	2.416e-48	186.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,43HEN@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
DYD2_k127_6103816_10	1101188.KI912155_gene3645	3.795e-06	59.0	2B9Y4@1|root,323BK@2|Bacteria,2H7YW@201174|Actinobacteria	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
DYD2_k127_6127946_0	926550.CLDAP_28350	1.899e-28	136.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
DYD2_k127_6127946_1	324602.Caur_0392	2.766e-20	108.0	COG1361@1|root,COG1470@1|root,COG1361@2|Bacteria,COG1470@2|Bacteria,2GA7Y@200795|Chloroflexi,376PQ@32061|Chloroflexia	32061|Chloroflexia	M	SMART Parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NPCBM_assoc
DYD2_k127_6127946_2	292459.STH718	0.0005254	56.0	COG1404@1|root,COG3291@1|root,COG4412@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,PPC,Peptidase_S8
DYD2_k127_6141408_6	1267533.KB906740_gene142	1.056e-12	81.0	COG1073@1|root,COG1073@2|Bacteria,3Y91X@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6141408_3	661478.OP10G_2737	6.633e-43	177.0	COG4638@1|root,COG4638@2|Bacteria	2|Bacteria	P	Rieske (2fe-2S)	-	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
DYD2_k127_6141408_2	224325.AF_1728	8.41e-50	195.0	COG0438@1|root,arCOG01403@2157|Archaea,2XVAJ@28890|Euryarchaeota,245P8@183980|Archaeoglobi	183980|Archaeoglobi	M	Glycosyltransferase Family 4	-	-	2.4.1.87	ko:K00743	ko00601,map00601	-	R05978,R06169	-	ko00000,ko00001,ko01000,ko01003	-	GT6	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_6141408_0	1121930.AQXG01000011_gene1751	6.802e-150	492.0	COG0624@1|root,COG0624@2|Bacteria,4NFGE@976|Bacteroidetes,1IQ95@117747|Sphingobacteriia	976|Bacteroidetes	E	Peptidase, family M20 M25 M40	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
DYD2_k127_6141408_1	521045.Kole_0416	1.015e-101	354.0	COG0846@1|root,COG0846@2|Bacteria	2|Bacteria	K	NAD+ binding	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2_2,TPR_8
DYD2_k127_6141408_5	1236689.MMALV_04650	1.376e-17	93.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
DYD2_k127_6141408_4	221109.22777425	3.901e-28	130.0	COG1418@1|root,COG1418@2|Bacteria,1V7IZ@1239|Firmicutes,4HIVB@91061|Bacilli,23KGU@182709|Oceanobacillus	91061|Bacilli	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	yagB	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
DYD2_k127_6141571_8	1235279.C772_02490	5.788e-70	244.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4HAKF@91061|Bacilli,26CWQ@186818|Planococcaceae	91061|Bacilli	P	Phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DYD2_k127_6141571_5	404589.Anae109_0421	3.568e-98	326.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2YUBB@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
DYD2_k127_6141571_18	1123288.SOV_2c08950	9.874e-41	164.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,4H2SY@909932|Negativicutes	909932|Negativicutes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
DYD2_k127_6141571_10	877420.ATVW01000007_gene908	2.733e-67	241.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,27IRE@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
DYD2_k127_6141571_25	589924.Ferp_1508	6.135e-17	92.0	COG1828@1|root,arCOG04462@2157|Archaea,2XYPB@28890|Euryarchaeota,246HY@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
DYD2_k127_6141571_0	693661.Arcve_1173	2.026e-258	823.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,245S4@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DYD2_k127_6141571_6	1054217.TALC_00152	5.745e-87	295.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,241Q4@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
DYD2_k127_6141571_14	444157.Tneu_1126	1.666e-49	187.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
DYD2_k127_6141571_27	381666.H16_A0147	1.412e-14	83.0	COG2021@1|root,COG2021@2|Bacteria,1QU84@1224|Proteobacteria,2VRYJ@28216|Betaproteobacteria,1K0JE@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM alpha beta hydrolase fold	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
DYD2_k127_6141571_28	192952.MM_2478	8.991e-14	87.0	COG2304@1|root,arCOG04500@1|root,arCOG02902@2157|Archaea,arCOG04500@2157|Archaea,2XVVH@28890|Euryarchaeota	28890|Euryarchaeota	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
DYD2_k127_6141571_4	587753.EY04_03830	4.106e-149	492.0	2DS9X@1|root,33F73@2|Bacteria,1NU3T@1224|Proteobacteria,1SKRG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	phosphatidylcholine-hydrolyzing phospholipase	plc	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6141571_30	1035193.HMPREF9073_01457	8.082e-12	76.0	COG0596@1|root,COG0596@2|Bacteria,4NDZI@976|Bacteroidetes,1HXF6@117743|Flavobacteriia,1EQI0@1016|Capnocytophaga	976|Bacteroidetes	S	alpha beta	ybfF	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
DYD2_k127_6141571_31	387092.NIS_0178	1.186e-11	78.0	2FB63@1|root,343CD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6141571_15	118166.JH976537_gene4918	1.272e-43	169.0	COG2258@1|root,COG2258@2|Bacteria,1GDB3@1117|Cyanobacteria,1HFCV@1150|Oscillatoriales	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
DYD2_k127_6141571_32	208444.JNYY01000005_gene6654	2.435e-10	70.0	2DQ4Z@1|root,334SM@2|Bacteria,2GWJC@201174|Actinobacteria,4E7K9@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF2568)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2568
DYD2_k127_6141571_17	1521187.JPIM01000002_gene3197	3.495e-43	182.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	yvoF	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
DYD2_k127_6141571_1	1094980.Mpsy_1449	3.854e-193	632.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
DYD2_k127_6141571_7	269797.Mbar_A1406	8.489e-76	265.0	COG0382@1|root,arCOG00478@2157|Archaea,2Y84D@28890|Euryarchaeota	2157|Archaea	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
DYD2_k127_6141571_16	502025.Hoch_6876	2.635e-43	170.0	COG0392@1|root,COG0392@2|Bacteria,1R4IS@1224|Proteobacteria,42WRK@68525|delta/epsilon subdivisions,2WSAB@28221|Deltaproteobacteria,2Z0VY@29|Myxococcales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
DYD2_k127_6141571_35	1120980.JQKH01000003_gene322	0.0002263	49.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2W3BE@28216|Betaproteobacteria,2KT3T@206351|Neisseriales	206351|Neisseriales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
DYD2_k127_6141571_19	1123319.AUBE01000015_gene5674	3.678e-39	166.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_6141571_2	639282.DEFDS_1642	8.681e-160	523.0	COG0043@1|root,COG0043@2|Bacteria,2GF8C@200930|Deferribacteres	200930|Deferribacteres	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
DYD2_k127_6141571_21	287986.DV20_41080	1.874e-36	158.0	COG0457@1|root,COG0457@2|Bacteria,2GR8Y@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12
DYD2_k127_6141571_9	529709.PYCH_00880	1.867e-67	245.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,243GQ@183968|Thermococci	183968|Thermococci	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
DYD2_k127_6141571_13	502558.EGYY_27480	8.113e-52	194.0	COG1704@1|root,COG1704@2|Bacteria,2GPS4@201174|Actinobacteria,4CV13@84998|Coriobacteriia	84998|Coriobacteriia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
DYD2_k127_6141571_12	1123298.KB904078_gene483	1.237e-56	211.0	COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,4HB11@91061|Bacilli	91061|Bacilli	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
DYD2_k127_6141571_22	795955.AFRW01000019_gene1853	5.72e-35	148.0	COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_6141571_3	673860.AciM339_1201	1.585e-150	524.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,3F2FP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
DYD2_k127_6141571_23	247490.KSU1_D0035	8.815e-31	132.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
DYD2_k127_6141571_29	1288298.rosmuc_03719	1.603e-12	78.0	COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria,46Q0E@74030|Roseovarius	28211|Alphaproteobacteria	S	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	alaS2	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
DYD2_k127_6141571_24	1519464.HY22_02845	1.755e-19	93.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF,Response_reg
DYD2_k127_6141571_34	1392838.AWNM01000009_gene2723	1.217e-07	65.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_6141571_33	368407.Memar_2068	1.413e-08	66.0	COG3398@1|root,arCOG02611@2157|Archaea	368407.Memar_2068|-	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6141571_26	797209.ZOD2009_08933	4.309e-15	88.0	COG0023@1|root,arCOG04223@2157|Archaea,2Y0K1@28890|Euryarchaeota,241EW@183963|Halobacteria	183963|Halobacteria	J	COG0023 Translation initiation factor 1 (eIF-1 SUI1) and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	SUI1
DYD2_k127_6141571_20	1123319.AUBE01000002_gene1241	2.458e-37	149.0	COG3483@1|root,COG3483@2|Bacteria,2ICER@201174|Actinobacteria	201174|Actinobacteria	E	Tryptophan 2,3-dioxygenase	-	-	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
DYD2_k127_6141571_11	1123368.AUIS01000011_gene1180	1.762e-58	230.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
DYD2_k127_6166199_2	1206101.AZXC01000021_gene2176	9.211e-26	123.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_6166199_3	751945.Theos_0616	3.77e-10	73.0	COG1351@1|root,COG1351@2|Bacteria,1WIPX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
DYD2_k127_6166199_0	222984.JNCS01000001_gene1981	1.102e-106	359.0	COG0446@1|root,arCOG01070@2157|Archaea,2XTPB@28890|Euryarchaeota,23TGY@183963|Halobacteria	183963|Halobacteria	S	NAD(FAD)-dependent dehydrogenases	noxA2	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
DYD2_k127_6166199_1	330214.NIDE1531	5.653e-65	237.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	trpH	-	3.1.3.97,4.1.2.13	ko:K01624,ko:K07053	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R00188,R01068,R01070,R01829,R02568,R11188	RC00078,RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
DYD2_k127_6166199_4	391623.TERMP_02057	1.012e-07	56.0	arCOG02836@1|root,arCOG02836@2157|Archaea,2XYP5@28890|Euryarchaeota,244GM@183968|Thermococci	183968|Thermococci	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain and a metal-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6207742_2	1408433.JHXV01000017_gene1620	3.75e-13	74.0	COG1607@1|root,COG1607@2|Bacteria,4PK4Y@976|Bacteroidetes,1IGGE@117743|Flavobacteriia,2PBZ1@246874|Cryomorphaceae	976|Bacteroidetes	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
DYD2_k127_6207742_7	1245475.ANAE01000158_gene3665	0.0001133	56.0	COG2372@1|root,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	copC	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
DYD2_k127_6207742_3	797114.C475_05950	1.311e-07	61.0	COG0642@1|root,arCOG06712@1|root,arCOG06192@2157|Archaea,arCOG06712@2157|Archaea,2Y7KG@28890|Euryarchaeota,240UR@183963|Halobacteria	183963|Halobacteria	T	COG2202 FOG PAS PAC domain	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HTH_10,PAS_4,PAS_9
DYD2_k127_6207742_1	436114.SYO3AOP1_0211	2.588e-158	512.0	COG0499@1|root,COG0499@2|Bacteria,2G3TI@200783|Aquificae	200783|Aquificae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
DYD2_k127_6207742_4	351160.RRC310	3.298e-07	60.0	COG3729@1|root,arCOG10926@2157|Archaea	2157|Archaea	S	general stress protein B in uncultured methanogenic archaeon (Q0W564)	-	-	-	-	-	-	-	-	-	-	-	-	LEA_5
DYD2_k127_6207742_6	1071073.KI530538_gene295	4.794e-05	53.0	COG3729@1|root,COG3729@2|Bacteria,1V71P@1239|Firmicutes,4HJ8A@91061|Bacilli,1ZGZA@1386|Bacillus	91061|Bacilli	S	general stress protein	gsiB	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	KGG,LEA_5
DYD2_k127_6207742_5	797302.Halru_1361	4.706e-06	51.0	COG3277@1|root,arCOG02466@2157|Archaea,2XZS0@28890|Euryarchaeota,23XMI@183963|Halobacteria	183963|Halobacteria	J	COG3277 RNA-binding protein involved in rRNA processing	gar1	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
DYD2_k127_6207742_0	1054217.TALC_00031	1.341e-167	530.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,241JU@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbA	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
DYD2_k127_6223991_1	240016.ABIZ01000001_gene1867	1.077e-116	406.0	COG0475@1|root,COG0475@2|Bacteria,46U4K@74201|Verrucomicrobia,2IV1A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C
DYD2_k127_6223991_3	266265.Bxe_B0037	6.603e-09	68.0	COG2267@1|root,COG2267@2|Bacteria,1P3EB@1224|Proteobacteria,2VIUP@28216|Betaproteobacteria,1K4F8@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid	mhpC	-	3.7.1.14	ko:K05714	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R02603,R06789	RC00752,RC00753,RC01337	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
DYD2_k127_6223991_4	1123073.KB899242_gene972	0.0005388	52.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1X43X@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
DYD2_k127_6223991_0	697303.Thewi_2302	6.259e-240	771.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
DYD2_k127_6223991_2	373903.Hore_09190	4.765e-43	166.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,3WBUJ@53433|Halanaerobiales	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
DYD2_k127_6238321_3	410358.Mlab_1487	1.696e-52	203.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,2N9D0@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
DYD2_k127_6238321_2	1284352.AOIG01000016_gene4041	8.805e-57	214.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26QK6@186822|Paenibacillaceae	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
DYD2_k127_6238321_4	1201288.M900_1245	4.542e-20	105.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,42PTT@68525|delta/epsilon subdivisions,2MT5U@213481|Bdellovibrionales,2WS13@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Zn_pept	-	-	3.4.17.18	ko:K05996	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14
DYD2_k127_6238321_6	661478.OP10G_1067	3.469e-07	63.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_6238321_5	264462.Bd3241	2.667e-09	67.0	COG1913@1|root,COG1913@2|Bacteria,1N88E@1224|Proteobacteria,42VD8@68525|delta/epsilon subdivisions,2MU0Y@213481|Bdellovibrionales,2WR9R@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6238321_1	1262914.BN533_01604	7.683e-80	288.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,4H27M@909932|Negativicutes	909932|Negativicutes	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
DYD2_k127_6238321_0	1094980.Mpsy_0259	3.665e-320	1017.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
DYD2_k127_6239128_4	1206730.BAGA01000127_gene4350	2.27e-22	112.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4FXXQ@85025|Nocardiaceae	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
DYD2_k127_6239128_7	37682.EMT23060	2.084e-07	61.0	2CY0S@1|root,2S16E@2759|Eukaryota,37VTN@33090|Viridiplantae,3GJDN@35493|Streptophyta,3M9F3@4447|Liliopsida,3INKE@38820|Poales	35493|Streptophyta	S	FHA domain-containing protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	FHA
DYD2_k127_6239128_8	1380354.JIAN01000005_gene1973	1.332e-05	55.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria	201174|Actinobacteria	K	arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_6239128_0	13333.ERN19945	2.204e-237	750.0	COG0443@1|root,KOG0102@2759|Eukaryota,37IHK@33090|Viridiplantae,3G7BX@35493|Streptophyta	35493|Streptophyta	O	Belongs to the heat shock protein 70 family	-	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006605,GO:0006810,GO:0006886,GO:0006950,GO:0008104,GO:0008150,GO:0009266,GO:0009408,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009579,GO:0009628,GO:0009941,GO:0010035,GO:0010038,GO:0015031,GO:0015833,GO:0031967,GO:0031975,GO:0033036,GO:0033365,GO:0034613,GO:0042221,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045036,GO:0045184,GO:0046686,GO:0046907,GO:0048046,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072594,GO:0072596,GO:0072598	-	ko:K03283	ko03040,ko04010,ko04141,ko04144,ko04213,ko04612,ko04915,ko05134,ko05145,ko05162,ko05164,ko05169,map03040,map04010,map04141,map04144,map04213,map04612,map04915,map05134,map05145,map05162,map05164,map05169	M00353,M00355	-	-	ko00000,ko00001,ko00002,ko01009,ko03009,ko03029,ko03041,ko03051,ko03110,ko04131,ko04147,ko04516	1.A.33.1	-	-	HSP70
DYD2_k127_6239128_5	138119.DSY4000	7.476e-21	100.0	COG3809@1|root,COG3809@2|Bacteria,1VIH3@1239|Firmicutes,24SJJ@186801|Clostridia,262W0@186807|Peptococcaceae	186801|Clostridia	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
DYD2_k127_6239128_3	502025.Hoch_6859	2.12e-50	184.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,42SRT@68525|delta/epsilon subdivisions,2WPB8@28221|Deltaproteobacteria,2YV8N@29|Myxococcales	28221|Deltaproteobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
DYD2_k127_6239128_2	1121930.AQXG01000016_gene1824	2.081e-94	339.0	COG0488@1|root,COG0488@2|Bacteria,4NG1W@976|Bacteroidetes,1IPB4@117747|Sphingobacteriia	976|Bacteroidetes	S	ABC transporter	yheS_3	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
DYD2_k127_6239128_1	351160.RCIX1823	2.902e-97	334.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,2N9C4@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
DYD2_k127_6239128_6	593750.Metfor_2529	5.393e-18	98.0	arCOG11331@1|root,arCOG11331@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
DYD2_k127_6252139_3	323848.Nmul_A1615	2.422e-06	58.0	COG1226@1|root,COG1226@2|Bacteria,1R97G@1224|Proteobacteria,2VQDK@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
DYD2_k127_6252139_1	1118153.MOY_14317	3.327e-29	127.0	COG2323@1|root,COG2323@2|Bacteria,1MW5I@1224|Proteobacteria,1S44G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
DYD2_k127_6252139_0	273063.STK_09740	9.321e-64	236.0	COG0438@1|root,arCOG01408@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
DYD2_k127_6252139_2	648757.Rvan_1541	2.816e-14	87.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1P5B8@1224|Proteobacteria,2UEQX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,DUF87,Hydrolase_3
DYD2_k127_6263034_16	1137271.AZUM01000005_gene294	1.293e-09	70.0	2CFT8@1|root,2ZBMC@2|Bacteria,2IFWU@201174|Actinobacteria,4E1RK@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6263034_17	906968.Trebr_1988	8.546e-08	65.0	COG4231@1|root,COG4231@2|Bacteria,2J5C0@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
DYD2_k127_6263034_19	1304880.JAGB01000001_gene315	5.557e-06	59.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
DYD2_k127_6263034_13	195522.BD01_1207	4.863e-12	77.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	183968|Thermococci	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_6263034_3	926560.KE387023_gene1627	1.252e-79	272.0	COG0225@1|root,COG0225@2|Bacteria,1WK2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
DYD2_k127_6263034_18	694440.JOMF01000004_gene1422	2.489e-07	58.0	COG5418@1|root,arCOG02433@2157|Archaea,2Y7HZ@28890|Euryarchaeota,2NA0T@224756|Methanomicrobia	224756|Methanomicrobia	S	nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
DYD2_k127_6263034_15	1144305.PMI02_05254	1.467e-11	69.0	COG3326@1|root,COG3326@2|Bacteria,1NGR5@1224|Proteobacteria,2UJDY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
DYD2_k127_6263034_7	1254432.SCE1572_22660	1.211e-33	141.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria,2Z01C@29|Myxococcales	28221|Deltaproteobacteria	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
DYD2_k127_6263034_10	1265505.ATUG01000001_gene3313	2.16e-12	79.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Peptidase T2, asparaginase 2	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
DYD2_k127_6263034_12	1265505.ATUG01000001_gene3312	3.247e-12	70.0	COG4242@1|root,COG4242@2|Bacteria,1PR9J@1224|Proteobacteria,4303E@68525|delta/epsilon subdivisions,2WV4V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	PQ	Belongs to the peptidase S51 family	-	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
DYD2_k127_6263034_11	693977.Deipr_1549	2.674e-12	78.0	COG1378@1|root,COG1378@2|Bacteria,1WNCB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_6263034_1	1227499.C493_07444	4.532e-112	391.0	COG1215@1|root,arCOG01389@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.336	ko:K19003	ko00561,ko01100,map00561,map01100	-	R02689	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3
DYD2_k127_6263034_4	1227457.C451_19523	3.441e-67	254.0	COG0270@1|root,arCOG04157@2157|Archaea,2Y2P1@28890|Euryarchaeota,23ZCR@183963|Halobacteria	183963|Halobacteria	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DNA_methylase
DYD2_k127_6263034_9	665956.HMPREF1032_03604	7.389e-23	111.0	COG4570@1|root,COG4570@2|Bacteria,1VF2H@1239|Firmicutes,24P18@186801|Clostridia	186801|Clostridia	L	Endodeoxyribonuclease RusA	rusA	-	-	-	-	-	-	-	-	-	-	-	RusA
DYD2_k127_6263034_6	643648.Slip_1826	9.601e-36	149.0	2C5J1@1|root,3067M@2|Bacteria,1V52W@1239|Firmicutes,24J2G@186801|Clostridia	186801|Clostridia	S	COG NOG12663 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6263034_8	1218075.BAYA01000003_gene602	4.929e-26	119.0	COG2214@1|root,COG2214@2|Bacteria,1N1HS@1224|Proteobacteria,2W2UD@28216|Betaproteobacteria,1KA00@119060|Burkholderiaceae	28216|Betaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6263034_2	1122917.KB899685_gene3237	5.391e-99	333.0	COG4422@1|root,COG4422@2|Bacteria,1TPP1@1239|Firmicutes,4HAU8@91061|Bacilli,26V16@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF5131)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
DYD2_k127_6263034_14	1381123.AYOD01000005_gene1292	1.27e-11	73.0	2CWYZ@1|root,32T0P@2|Bacteria,1MZEM@1224|Proteobacteria,2UCCZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6263034_5	1459636.NTE_03049	6.627e-43	169.0	COG0122@1|root,arCOG00464@2157|Archaea	2157|Archaea	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
DYD2_k127_6263034_0	1071085.KK033114_gene179	9.596e-175	573.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,23SII@183963|Halobacteria	183963|Halobacteria	L	ATPase involved in replication control, Cdc46 Mcm family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,HTH_31,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB
DYD2_k127_6299190_32	1273125.Rrhod_3784	5.533e-05	58.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4FUYR@85025|Nocardiaceae	201174|Actinobacteria	T	Oxidoreductase molybdopterin binding domain	-	-	1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
DYD2_k127_6299190_26	1552758.NC00_17100	1.095e-21	113.0	COG2199@1|root,COG3292@1|root,COG2199@2|Bacteria,COG3292@2|Bacteria,1RGCV@1224|Proteobacteria,1T227@1236|Gammaproteobacteria,1XD7F@135614|Xanthomonadales	135614|Xanthomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Reg_prop,Y_Y_Y
DYD2_k127_6299190_31	751944.HALDL1_03215	5.381e-05	56.0	COG5276@1|root,arCOG02565@2157|Archaea,2XV6J@28890|Euryarchaeota,23SNQ@183963|Halobacteria	183963|Halobacteria	O	LVIVD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
DYD2_k127_6299190_16	1128421.JAGA01000002_gene1039	5.958e-34	149.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2NR4E@2323|unclassified Bacteria	2|Bacteria	H	MoaE protein	moaD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.77,2.8.1.12,4.6.1.17	ko:K03635,ko:K03636,ko:K03637,ko:K03752,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395,R11372,R11581	RC02507,RC03425	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_0736,iEC55989_1330.EC55989_0827,iG2583_1286.G2583_1012,iLF82_1304.LF82_1368,iNRG857_1313.NRG857_03495,iSFV_1184.SFV_0767,iSF_1195.SF0734,iSFxv_1172.SFxv_0800,iSSON_1240.SSON_0763,iS_1188.S0775	MoaE,ThiS
DYD2_k127_6299190_10	572546.Arcpr_0294	3.683e-46	174.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,24741@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
DYD2_k127_6299190_13	309801.trd_1044	4.692e-38	157.0	COG0521@1|root,COG0521@2|Bacteria,2G6YJ@200795|Chloroflexi,27Y8Y@189775|Thermomicrobia	189775|Thermomicrobia	H	May be involved in the biosynthesis of molybdopterin	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
DYD2_k127_6299190_1	439481.Aboo_0536	1.637e-107	359.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,3F2IT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
DYD2_k127_6299190_25	1151117.AJLF01000001_gene1559	1.795e-22	102.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,2449J@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
DYD2_k127_6299190_23	195250.CM001776_gene3077	1.278e-24	116.0	COG0603@1|root,COG0603@2|Bacteria,1G24C@1117|Cyanobacteria,1GYSF@1129|Synechococcus	1117|Cyanobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
DYD2_k127_6299190_9	1173024.KI912149_gene5722	1.564e-47	185.0	COG0300@1|root,COG0300@2|Bacteria,1G7GB@1117|Cyanobacteria,1JJH1@1189|Stigonemataceae	1117|Cyanobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_6299190_29	1121106.JQKB01000012_gene4669	1.525e-08	68.0	COG4221@1|root,COG4221@2|Bacteria,1MUU6@1224|Proteobacteria,2TQW8@28211|Alphaproteobacteria,2JYYG@204441|Rhodospirillales	204441|Rhodospirillales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
DYD2_k127_6299190_14	395495.Lcho_0404	7.513e-37	151.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VMTP@28216|Betaproteobacteria,1KN4E@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
DYD2_k127_6299190_30	742741.HMPREF9475_03115	3.531e-06	57.0	COG0727@1|root,COG0727@2|Bacteria,1TT6P@1239|Firmicutes,24BWS@186801|Clostridia,21YGV@1506553|Lachnoclostridium	186801|Clostridia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
DYD2_k127_6299190_21	1054217.TALC_00198	2.42e-29	134.0	arCOG05338@1|root,arCOG05338@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6299190_28	634498.mru_1281	1.395e-15	78.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
DYD2_k127_6299190_33	1227488.C477_05389	0.0003659	50.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XU61@28890|Euryarchaeota,23TWQ@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
DYD2_k127_6299190_4	485913.Krac_10598	1.707e-93	340.0	COG1398@1|root,COG1398@2|Bacteria,2G88P@200795|Chloroflexi	200795|Chloroflexi	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
DYD2_k127_6299190_11	66874.JOFS01000049_gene3200	9.11e-44	179.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_6299190_6	593750.Metfor_0196	6.169e-71	251.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,2N945@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM elongation factor Tu domain 2	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
DYD2_k127_6299190_12	1041930.Mtc_2313	4.73e-39	168.0	COG1624@1|root,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota,2N9M8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N
DYD2_k127_6299190_22	66869.JNXG01000004_gene2420	2.653e-29	126.0	COG0431@1|root,COG0431@2|Bacteria,2GNFR@201174|Actinobacteria,41AI4@629295|Streptomyces griseus group	201174|Actinobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
DYD2_k127_6299190_24	580332.Slit_0467	1.542e-23	106.0	COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,2VWG2@28216|Betaproteobacteria,44W37@713636|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Excinuclease ABC C subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
DYD2_k127_6299190_3	529709.PYCH_12930	5.613e-103	355.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
DYD2_k127_6299190_15	929713.NIASO_07670	9.531e-36	142.0	COG0614@1|root,COG0614@2|Bacteria,4NS2Y@976|Bacteroidetes,1IYF9@117747|Sphingobacteriia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
DYD2_k127_6299190_2	439481.Aboo_0476	2.225e-103	358.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,3F2ET@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
DYD2_k127_6299190_18	1122919.KB905551_gene1755	4.958e-33	141.0	2DBAY@1|root,2Z84S@2|Bacteria,1UJ57@1239|Firmicutes,4IT21@91061|Bacilli,2777U@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF1835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1835
DYD2_k127_6299190_5	1380390.JIAT01000012_gene3302	3.154e-89	322.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6299190_27	869210.Marky_0436	4.997e-18	93.0	COG1011@1|root,COG1011@2|Bacteria,1WIPE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
DYD2_k127_6299190_8	1121406.JAEX01000001_gene433	9.252e-62	222.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WNYM@28221|Deltaproteobacteria,2MG63@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
DYD2_k127_6299190_7	1128427.KB904821_gene3775	3.788e-68	243.0	COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,1H8MW@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
DYD2_k127_6299190_17	314254.OA2633_09159	1.45e-33	137.0	COG2240@1|root,COG4923@1|root,COG2240@2|Bacteria,COG4923@2|Bacteria,1MY1R@1224|Proteobacteria,2U4CU@28211|Alphaproteobacteria,440PB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
DYD2_k127_6299190_19	1094980.Mpsy_0839	2.023e-30	139.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAP1@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DYD2_k127_6299190_20	679926.Mpet_1820	3.142e-30	139.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAGM@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DYD2_k127_6299190_0	679926.Mpet_1819	7.436e-137	456.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DYD2_k127_6334315_0	1151117.AJLF01000003_gene669	2.885e-31	136.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
DYD2_k127_6382544_0	1041930.Mtc_2081	9.27e-127	431.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NA8T@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
DYD2_k127_6427998_1	272557.APE_1958.1	0.0001291	46.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
DYD2_k127_6427998_0	1174504.AJTN02000230_gene1253	1.412e-59	234.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,4HBBH@91061|Bacilli,1ZBDP@1386|Bacillus	91061|Bacilli	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
DYD2_k127_6451551_3	357808.RoseRS_1478	3.303e-09	70.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2G84A@200795|Chloroflexi,376BB@32061|Chloroflexia	200795|Chloroflexi	LV	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6451551_1	118173.KB235914_gene394	8.418e-30	138.0	COG4403@1|root,COG4403@2|Bacteria,1G1PI@1117|Cyanobacteria,1H9Z7@1150|Oscillatoriales	1117|Cyanobacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6451551_0	391587.KAOT1_13827	1.787e-42	179.0	COG4403@1|root,COG4403@2|Bacteria,4NMZP@976|Bacteroidetes,1I2M8@117743|Flavobacteriia	976|Bacteroidetes	V	Lanthionine synthetase C-like protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like
DYD2_k127_6451551_2	1173024.KI912148_gene2505	1.37e-09	72.0	COG1511@1|root,COG1511@2|Bacteria,1G29D@1117|Cyanobacteria	1117|Cyanobacteria	L	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,Tubulin_2,zinc_ribbon_2
DYD2_k127_6462080_4	673860.AciM339_0303	1.745e-60	216.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,3F2KH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Helix-hairpin-helix motif	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
DYD2_k127_6462080_7	673860.AciM339_0302	4.49e-15	80.0	COG1460@1|root,arCOG01016@2157|Archaea,2Y6FQ@28890|Euryarchaeota,3F2SK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	RNA polymerase	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
DYD2_k127_6462080_5	647113.Metok_0970	1.01e-22	107.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,23R0X@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
DYD2_k127_6462080_6	1192034.CAP_5666	1.102e-20	107.0	COG5184@1|root,COG5184@2|Bacteria,1QX3H@1224|Proteobacteria,42QVK@68525|delta/epsilon subdivisions,2WN77@28221|Deltaproteobacteria	28221|Deltaproteobacteria	DZ	cell wall surface anchor family protein	-	-	-	-	-	-	-	-	-	-	-	-	RCC1_2
DYD2_k127_6462080_1	1094980.Mpsy_2776	2.322e-104	355.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
DYD2_k127_6462080_2	1120950.KB892707_gene4619	1.945e-101	351.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria	201174|Actinobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
DYD2_k127_6462080_3	404589.Anae109_1008	4.271e-80	275.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YV5B@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
DYD2_k127_6462080_0	204669.Acid345_2863	8.467e-113	384.0	COG3285@1|root,COG3285@2|Bacteria,3Y637@57723|Acidobacteria,2JM9H@204432|Acidobacteriia	204432|Acidobacteriia	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
DYD2_k127_6462080_9	573065.Astex_1996	1.179e-12	79.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2V5S6@28211|Alphaproteobacteria,2KHZ3@204458|Caulobacterales	204458|Caulobacterales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
DYD2_k127_6462080_8	1236689.MMALV_00680	1.155e-13	82.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y6XW@28890|Euryarchaeota,3F2UA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
DYD2_k127_6462080_10	521011.Mpal_2591	1.881e-07	64.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,2NA09@224756|Methanomicrobia	224756|Methanomicrobia	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
DYD2_k127_6462080_11	929712.KI912613_gene4279	0.0001157	47.0	2A5VU@1|root,30UMP@2|Bacteria,2HRRK@201174|Actinobacteria,4CTU7@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_646514_1	565033.GACE_1936	2.211e-05	54.0	COG3398@1|root,arCOG02611@2157|Archaea,2XZ7M@28890|Euryarchaeota,246E6@183980|Archaeoglobi	183980|Archaeoglobi	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_646514_0	321327.CYA_2353	8.423e-85	289.0	COG4221@1|root,COG4221@2|Bacteria,1G182@1117|Cyanobacteria,1GZUC@1129|Synechococcus	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.276	ko:K05886	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
DYD2_k127_6477637_1	439481.Aboo_0186	1.432e-152	497.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,3F2II@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
DYD2_k127_6477637_9	941449.dsx2_1342	1.343e-32	134.0	COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,42TS3@68525|delta/epsilon subdivisions,2WQN1@28221|Deltaproteobacteria,2MCJM@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
DYD2_k127_6477637_14	1123227.KB899334_gene1841	1.708e-08	60.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,2JTCN@204441|Rhodospirillales	204441|Rhodospirillales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
DYD2_k127_6477637_6	684949.ATTJ01000003_gene3233	5.311e-37	151.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
DYD2_k127_6477637_8	479434.Sthe_2016	5.092e-36	139.0	COG0073@1|root,COG0073@2|Bacteria,2G74R@200795|Chloroflexi,27YK6@189775|Thermomicrobia	189775|Thermomicrobia	J	Putative tRNA binding domain	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
DYD2_k127_6477637_11	1123024.AUII01000002_gene1164	2.296e-20	104.0	2C75R@1|root,2ZCK5@2|Bacteria,2IBVD@201174|Actinobacteria,4E8JR@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6477637_7	1463881.KL591039_gene3415	2.521e-36	155.0	COG2267@1|root,COG2267@2|Bacteria,2I3E4@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the peptidase S33 family	-	-	3.5.1.101	ko:K18457	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
DYD2_k127_6477637_3	1235279.C772_02295	1.183e-112	376.0	COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,4HBYT@91061|Bacilli,26D0N@186818|Planococcaceae	91061|Bacilli	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
DYD2_k127_6477637_4	3055.EDP01339	1.088e-54	203.0	COG0463@1|root,KOG2978@2759|Eukaryota,37IN4@33090|Viridiplantae,34JQ8@3041|Chlorophyta	3041|Chlorophyta	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	iRC1080.CRv4_Au5_s3_g10178_t1	Glycos_transf_2
DYD2_k127_6477637_13	398512.JQKC01000002_gene1937	1.713e-10	73.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
DYD2_k127_6477637_10	326427.Cagg_0880	2.372e-26	124.0	COG0438@1|root,COG0438@2|Bacteria,2GANK@200795|Chloroflexi,374UX@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
DYD2_k127_6477637_5	1144275.COCOR_06462	1.112e-40	171.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,433WA@68525|delta/epsilon subdivisions,2X3U0@28221|Deltaproteobacteria,2YX3S@29|Myxococcales	28221|Deltaproteobacteria	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
DYD2_k127_6477637_12	292459.STH541	5.444e-14	78.0	COG0239@1|root,COG0239@2|Bacteria	2|Bacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
DYD2_k127_6477637_2	439481.Aboo_0743	8.672e-149	514.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,3F2HT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
DYD2_k127_6477637_0	439481.Aboo_0742	9.567e-197	639.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,3F2EU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
DYD2_k127_6488265_9	258052.JNYV01000004_gene4183	1.073e-05	53.0	COG0640@1|root,COG0640@2|Bacteria,2IKWF@201174|Actinobacteria,2M5WQ@2063|Kitasatospora	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_6488265_3	404589.Anae109_2479	3.907e-49	184.0	COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
DYD2_k127_6488265_7	521011.Mpal_0956	1.462e-11	73.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
DYD2_k127_6488265_6	263820.PTO0407	2.166e-32	130.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,241RG@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
DYD2_k127_6488265_10	101510.RHA1_ro02662	0.0001887	52.0	COG3631@1|root,COG3631@2|Bacteria,2HWPG@201174|Actinobacteria,4G56X@85025|Nocardiaceae	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
DYD2_k127_6488265_2	1386089.N865_05350	9.493e-51	206.0	COG4733@1|root,COG4733@2|Bacteria,2I7XV@201174|Actinobacteria,4FK2V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
DYD2_k127_6488265_5	160799.PBOR_12955	9.023e-35	144.0	COG0500@1|root,COG2226@2|Bacteria,1VCAB@1239|Firmicutes,4HTCX@91061|Bacilli,271JN@186822|Paenibacillaceae	91061|Bacilli	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
DYD2_k127_6488265_8	1210908.HSB1_11090	4.217e-07	63.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_6488265_0	1041930.Mtc_1205	3.652e-132	434.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,2N9RK@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
DYD2_k127_6488265_1	765420.OSCT_0450	1.177e-76	266.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,374VN@32061|Chloroflexia	32061|Chloroflexia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
DYD2_k127_6488265_4	1007103.AFHW01000160_gene3089	6.435e-49	184.0	COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,4H9PJ@91061|Bacilli,26R2G@186822|Paenibacillaceae	91061|Bacilli	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA_2	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
DYD2_k127_6509566_2	368407.Memar_1272	1.446e-09	70.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_6509566_0	398767.Glov_2930	1.834e-68	245.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
DYD2_k127_6509566_1	283942.IL0926	7.441e-26	124.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,2QFK9@267893|Idiomarinaceae	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404	GlutR_N,GlutR_dimer,Shikimate_DH
DYD2_k127_652414_6	1198449.ACAM_0020	9.357e-73	254.0	COG1845@1|root,arCOG04650@2157|Archaea	2157|Archaea	C	Heme copper-type cytochrome quinol	-	-	1.9.3.1,2.7.11.1	ko:K02276,ko:K12132,ko:K15408	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000,ko01001	3.D.4.4,3.D.4.6	-	-	COX1,COX3
DYD2_k127_652414_8	1118054.CAGW01000072_gene1703	5.349e-69	243.0	COG0682@1|root,COG0682@2|Bacteria,1V4MF@1239|Firmicutes,4HHW8@91061|Bacilli,26TS9@186822|Paenibacillaceae	91061|Bacilli	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	-	-	-	-	-	-	-	-	-	LGT
DYD2_k127_652414_0	1284352.AOIG01000008_gene2309	2.01e-142	466.0	COG1964@1|root,COG1964@2|Bacteria,1TVES@1239|Firmicutes,4HC4D@91061|Bacilli,26U38@186822|Paenibacillaceae	91061|Bacilli	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM
DYD2_k127_652414_5	1068980.ARVW01000001_gene7397	4.59e-88	313.0	COG2220@1|root,COG2220@2|Bacteria,2GNXJ@201174|Actinobacteria,4DYA7@85010|Pseudonocardiales	201174|Actinobacteria	S	Zn-dependent hydrolase of beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
DYD2_k127_652414_21	78245.Xaut_0975	2.298e-06	56.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
DYD2_k127_652414_17	593750.Metfor_1391	5.188e-19	92.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
DYD2_k127_652414_16	1041930.Mtc_0861	3.672e-21	100.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,2N9TP@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
DYD2_k127_652414_22	1121945.ATXS01000010_gene1648	0.0001523	54.0	COG2892@1|root,arCOG04414@2157|Archaea,2XZUI@28890|Euryarchaeota,23XE5@183963|Halobacteria	183963|Halobacteria	S	KEOPS complex Pcc1-like subunit	pcc1	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
DYD2_k127_652414_19	1094980.Mpsy_2732	4.514e-09	64.0	COG1996@1|root,arCOG04341@2157|Archaea,2XZUD@28890|Euryarchaeota,2NA5N@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
DYD2_k127_652414_15	402880.MmarC5_1424	2.807e-23	103.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,23R0T@183939|Methanococci	183939|Methanococci	J	ribosomal protein	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
DYD2_k127_652414_14	215803.DB30_0844	1.578e-24	117.0	COG0560@1|root,COG0560@2|Bacteria,1RCZP@1224|Proteobacteria,42VP5@68525|delta/epsilon subdivisions,2X5MD@28221|Deltaproteobacteria,2YXKZ@29|Myxococcales	28221|Deltaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
DYD2_k127_652414_4	192952.MM_2480	6.971e-101	348.0	COG1007@1|root,arCOG01540@2157|Archaea,2XSY7@28890|Euryarchaeota,2N9SZ@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	1.5.98.3	ko:K22169	-	-	-	-	ko00000,ko01000	3.D.9.1	-	iAF692.Mbar_A3401	Proton_antipo_M
DYD2_k127_652414_3	329726.AM1_2126	2.13e-102	352.0	COG1008@1|root,COG1008@2|Bacteria,1G0VB@1117|Cyanobacteria	1117|Cyanobacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ndhD2	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhD2	Oxidored_q5_N,Proton_antipo_M
DYD2_k127_652414_1	1236689.MMALV_02040	1.401e-137	465.0	COG1009@1|root,arCOG01539@2157|Archaea,2Y85E@28890|Euryarchaeota	28890|Euryarchaeota	C	Proton-conducting membrane transporter	-	-	-	ko:K05565,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
DYD2_k127_652414_13	1094980.Mpsy_2574	3.917e-25	107.0	COG0713@1|root,arCOG03073@2157|Archaea,2XXW4@28890|Euryarchaeota,2NB01@224756|Methanomicrobia	224756|Methanomicrobia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.5.98.3	ko:K22166	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Oxidored_q2
DYD2_k127_652414_18	28444.JODQ01000018_gene7261	6.111e-13	75.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4EIJM@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
DYD2_k127_652414_12	273075.Ta0965	1.879e-26	113.0	COG1143@1|root,arCOG01543@2157|Archaea,2Y79M@28890|Euryarchaeota,241VP@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
DYD2_k127_652414_7	1009370.ALO_00250	2.428e-72	257.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,4H24V@909932|Negativicutes	909932|Negativicutes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
DYD2_k127_652414_2	491915.Aflv_2697	4.563e-122	402.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,4HA4Y@91061|Bacilli,21W71@150247|Anoxybacillus	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
DYD2_k127_652414_10	1033743.CAES01000105_gene3584	3.894e-31	135.0	COG0852@1|root,COG0852@2|Bacteria,1UFNI@1239|Firmicutes,4HDV1@91061|Bacilli,26RPJ@186822|Paenibacillaceae	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
DYD2_k127_652414_9	1382306.JNIM01000001_gene993	7.598e-58	219.0	COG0377@1|root,COG0377@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
DYD2_k127_652414_11	1123400.KB904758_gene2397	1.212e-26	118.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,460WP@72273|Thiotrichales	72273|Thiotrichales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
DYD2_k127_6526669_0	502025.Hoch_1742	5.142e-185	595.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
DYD2_k127_6526669_4	1163407.UU7_02712	2.627e-13	79.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X3GA@135614|Xanthomonadales	135614|Xanthomonadales	P	Heavy metal translocating P-type atpase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
DYD2_k127_6526669_3	1042877.GQS_00750	1.354e-14	83.0	COG1522@1|root,arCOG01585@2157|Archaea,2XYZV@28890|Euryarchaeota,245CM@183968|Thermococci	183968|Thermococci	K	Archaeal TRASH domain	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_24
DYD2_k127_6526669_5	1144312.PMI09_04649	7.365e-08	56.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,4B7RZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Cation transport ATPase	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
DYD2_k127_6526669_2	457429.ABJI02000741_gene333	7.883e-50	184.0	COG1018@1|root,COG1018@2|Bacteria,2IN34@201174|Actinobacteria	201174|Actinobacteria	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6526669_1	661478.OP10G_1096	2.068e-128	428.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	yhfW	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO,Rieske
DYD2_k127_6526669_6	1121272.KB903252_gene1016	1.074e-07	63.0	COG2345@1|root,COG2345@2|Bacteria,2GN8W@201174|Actinobacteria,4D9KQ@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional regulator	sufR	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
DYD2_k127_655642_6	1265502.KB905953_gene759	7.741e-23	101.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGKF@28216|Betaproteobacteria,4AGRT@80864|Comamonadaceae	28216|Betaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
DYD2_k127_655642_10	1432055.GLUCORHAEAF1_07850	1.539e-10	62.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales	204441|Rhodospirillales	P	COG2217 Cation transport ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
DYD2_k127_655642_3	1485544.JQKP01000008_gene1705	1.786e-27	128.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VQEJ@28216|Betaproteobacteria,44WFQ@713636|Nitrosomonadales	28216|Betaproteobacteria	KT	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
DYD2_k127_655642_12	1380370.JIBA01000012_gene3964	1.731e-06	61.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4FF6K@85021|Intrasporangiaceae	201174|Actinobacteria	P	P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
DYD2_k127_655642_0	930171.Asphe3_31160	7.998e-40	155.0	COG3544@1|root,COG3544@2|Bacteria,2IFX2@201174|Actinobacteria,1WC4T@1268|Micrococcaceae	201174|Actinobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
DYD2_k127_655642_2	525904.Tter_2558	4.287e-33	135.0	COG1814@1|root,COG1814@2|Bacteria,2NRID@2323|unclassified Bacteria	2|Bacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
DYD2_k127_655642_8	413816.BBJP01000001_gene33	2.197e-13	78.0	COG3413@1|root,arCOG02271@2157|Archaea,2XU8X@28890|Euryarchaeota,23THS@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	BAT,HTH_10
DYD2_k127_655642_9	292415.Tbd_2614	2.13e-12	80.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VSW6@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
DYD2_k127_655642_4	1033806.HTIA_1220	8.666e-25	112.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2Y7UN@28890|Euryarchaeota,240XA@183963|Halobacteria	183963|Halobacteria	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
DYD2_k127_655642_13	416348.Hlac_1587	0.0001024	46.0	arCOG06415@1|root,arCOG06415@2157|Archaea	2157|Archaea	L	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	zf-HIT
DYD2_k127_655642_11	1033810.HLPCO_002080	1.29e-08	65.0	2DPK9@1|root,332H1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_655642_5	1132442.KB889752_gene972	1.017e-23	113.0	28JDE@1|root,2Z97T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_655642_7	717606.PaecuDRAFT_4730	1.021e-13	75.0	2BGW7@1|root,32AW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_655642_1	1126627.BAWE01000002_gene542	9.546e-34	132.0	2B5NQ@1|root,31YI3@2|Bacteria,1RH5V@1224|Proteobacteria,2U99Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4188
DYD2_k127_6570945_6	391037.Sare_2758	1.071e-06	58.0	COG1309@1|root,COG1309@2|Bacteria,2IK0Z@201174|Actinobacteria,4DM6W@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
DYD2_k127_6570945_0	439481.Aboo_0070	5.385e-70	239.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,3F2K0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
DYD2_k127_6570945_1	1054217.TALC_00387	1.165e-66	235.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,241NY@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
DYD2_k127_6570945_4	1041930.Mtc_1603	1.747e-37	154.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
DYD2_k127_6570945_2	572547.Amico_0087	4.597e-60	230.0	COG1893@1|root,COG1893@2|Bacteria,3TAIK@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
DYD2_k127_6570945_5	690850.Desaf_3258	8.879e-19	93.0	COG3293@1|root,COG3293@2|Bacteria,1R5NV@1224|Proteobacteria,430FR@68525|delta/epsilon subdivisions,2WVKI@28221|Deltaproteobacteria,2MFEK@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2,DUF4096
DYD2_k127_6570945_3	1172188.KB911824_gene3399	9.606e-42	169.0	28JU0@1|root,2Z9J3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_6707006_1	931277.C448_14303	3.14e-60	222.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,23UTP@183963|Halobacteria	183963|Halobacteria	J	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
DYD2_k127_6707006_2	1094980.Mpsy_0483	3.888e-09	67.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota	28890|Euryarchaeota	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
DYD2_k127_6707006_0	706587.Desti_2694	9.944e-94	320.0	COG0057@1|root,COG0057@2|Bacteria,1N2N1@1224|Proteobacteria	1224|Proteobacteria	G	Glyceraldehyde-3-phosphate dehydrogenase	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
DYD2_k127_6727766_2	344747.PM8797T_06617	1.051e-42	163.0	COG0573@1|root,COG0573@2|Bacteria,2IZ0E@203682|Planctomycetes	203682|Planctomycetes	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
DYD2_k127_6727766_1	555079.Toce_0354	6.27e-74	261.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,42EPR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM extracellular solute-binding protein family 1	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	Big_5,PBP_like_2
DYD2_k127_6727766_3	323259.Mhun_1022	2.371e-42	168.0	COG1392@1|root,arCOG02640@2157|Archaea	2157|Archaea	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
DYD2_k127_6727766_0	368407.Memar_1038	3.41e-85	303.0	COG0306@1|root,arCOG02267@2157|Archaea,2XSUU@28890|Euryarchaeota,2N9TT@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
DYD2_k127_6727766_4	1487953.JMKF01000053_gene1785	1.197e-23	113.0	COG0730@1|root,COG0730@2|Bacteria,1G0VP@1117|Cyanobacteria,1H7V5@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
DYD2_k127_692288_0	290397.Adeh_1419	3.014e-180	594.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Peptidase M1 membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,ERAP1_C,Peptidase_M1
DYD2_k127_692288_1	1261545.MBE-HAL_1555	6.433e-45	179.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVWR@28890|Euryarchaeota,23UPZ@183963|Halobacteria	183963|Halobacteria	P	COG1055 Na H antiporter NhaD and related arsenite permeases	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
DYD2_k127_700041_7	1122605.KB893637_gene3106	6.703e-15	78.0	COG0308@1|root,COG0308@2|Bacteria,4NGUB@976|Bacteroidetes	976|Bacteroidetes	E	peptidase M1	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
DYD2_k127_700041_0	1144275.COCOR_02590	6.932e-166	533.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,42MN7@68525|delta/epsilon subdivisions,2WIVK@28221|Deltaproteobacteria,2YYIN@29|Myxococcales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
DYD2_k127_700041_11	1382305.AZUC01000056_gene2076	0.0002096	53.0	COG1942@1|root,COG1942@2|Bacteria,1VKD5@1239|Firmicutes,4HRBS@91061|Bacilli,26G1I@186818|Planococcaceae	91061|Bacilli	G	4-oxalocrotonate tautomerase	dmpI	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0044237	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
DYD2_k127_700041_9	1278073.MYSTI_05938	1.527e-06	61.0	COG2304@1|root,COG2304@2|Bacteria,1R5EY@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_700041_3	234267.Acid_2453	6.387e-84	295.0	COG3959@1|root,COG3959@2|Bacteria,3Y4PX@57723|Acidobacteria	57723|Acidobacteria	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
DYD2_k127_700041_4	485918.Cpin_5471	4.414e-67	250.0	COG0823@1|root,COG0823@2|Bacteria,4NJA6@976|Bacteroidetes,1IPP8@117747|Sphingobacteriia	976|Bacteroidetes	U	Phosphatidylinositol diacylglycerol-lyase	-	-	4.6.1.13	ko:K01771	ko00562,map00562	-	R03332	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	PI-PLC-X
DYD2_k127_700041_2	635013.TherJR_2764	1.499e-95	322.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
DYD2_k127_700041_8	1297742.A176_02179	2.13e-09	68.0	2E4CN@1|root,32Z83@2|Bacteria,1REKZ@1224|Proteobacteria	1224|Proteobacteria	S	Putative abortive phage resistance protein AbiGi, antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	AbiGi
DYD2_k127_700041_6	926550.CLDAP_15510	7.107e-25	113.0	COG1564@1|root,COG1564@2|Bacteria,2G6VK@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Thiamin pyrophosphokinase, catalytic region	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
DYD2_k127_700041_5	266117.Rxyl_1116	2.786e-65	233.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4CPJK@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
DYD2_k127_700041_1	345341.KUTG_03345	7.476e-99	332.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4E0JW@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
DYD2_k127_700041_10	414684.RC1_3893	5.869e-05	48.0	2EGUP@1|root,33AKU@2|Bacteria,1NIPS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_704470_1	935866.JAER01000053_gene2978	3.517e-11	74.0	2CFT8@1|root,2ZBMC@2|Bacteria,2IFWU@201174|Actinobacteria,4DU12@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_704470_0	673860.AciM339_0595	3.671e-92	315.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,3F2JJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Belongs to the peptidase M24B family	pepQ1	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
DYD2_k127_704470_2	1209984.BN978_01371	0.0001473	53.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
DYD2_k127_72079_7	413816.BBJP01000019_gene1377	0.0003741	53.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,23TPF@183963|Halobacteria	183963|Halobacteria	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
DYD2_k127_72079_4	1459636.NTE_02622	4.994e-26	111.0	COG0316@1|root,arCOG04560@2157|Archaea,41SKH@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Iron-sulfur cluster assembly accessory protein	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
DYD2_k127_72079_3	877455.Metbo_0292	1.948e-26	121.0	COG0720@1|root,arCOG02172@2157|Archaea,2XXFY@28890|Euryarchaeota,23PMK@183925|Methanobacteria	183925|Methanobacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
DYD2_k127_72079_1	661478.OP10G_3388	1.513e-81	280.0	COG0294@1|root,COG0294@2|Bacteria	2|Bacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_3924,iPC815.YPO3501	Pterin_bind
DYD2_k127_72079_5	1158606.I579_00073	9.566e-18	87.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4HKKK@91061|Bacilli,4B36R@81852|Enterococcaceae	91061|Bacilli	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
DYD2_k127_72079_8	485914.Hmuk_3371	0.0007468	52.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XUKS@28890|Euryarchaeota,23S6W@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
DYD2_k127_72079_6	797114.C475_06285	1.515e-05	57.0	COG3413@1|root,arCOG02272@2157|Archaea,2XUBY@28890|Euryarchaeota,23UBQ@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
DYD2_k127_72079_0	224325.AF_0200	2.879e-139	467.0	COG1022@1|root,arCOG04199@2157|Archaea,2XT0U@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
DYD2_k127_72079_2	1173028.ANKO01000112_gene4818	1.814e-41	156.0	COG2081@1|root,COG2081@2|Bacteria,1FZZ1@1117|Cyanobacteria,1H7GT@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
DYD2_k127_74445_3	439481.Aboo_0139	1.007e-17	98.0	COG4906@1|root,arCOG00568@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2206
DYD2_k127_74445_1	1121430.JMLG01000013_gene1893	6.059e-131	432.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,2609V@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
DYD2_k127_74445_2	1380347.JNII01000005_gene3745	1.257e-38	168.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,CBM_35,F5_F8_type_C,Pectate_lyase_3
DYD2_k127_74445_4	1296415.JACC01000006_gene1524	5.895e-14	87.0	COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,1HYAE@117743|Flavobacteriia,2YI3U@290174|Aquimarina	976|Bacteroidetes	C	Sodium:dicarboxylate symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
DYD2_k127_74445_0	215803.DB30_8704	2.704e-151	487.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria,2YXPN@29|Myxococcales	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
DYD2_k127_821949_5	387631.Asulf_00195	2.666e-74	260.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,245VI@183980|Archaeoglobi	183980|Archaeoglobi	C	Belongs to the LDH MDH superfamily	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
DYD2_k127_821949_2	292459.STH2403	4.104e-91	315.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes	1239|Firmicutes	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
DYD2_k127_821949_4	661478.OP10G_4167	5.304e-76	265.0	COG2107@1|root,COG2107@2|Bacteria	2|Bacteria	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K07083,ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
DYD2_k127_821949_11	1236689.MMALV_16630	2.341e-53	209.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,3F2P3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,TRAM
DYD2_k127_821949_9	743525.TSC_c02650	1.03e-56	208.0	COG1024@1|root,COG1024@2|Bacteria,1WIYN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Enoyl-CoA hydratase isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_821949_6	329726.AM1_5157	7.771e-73	277.0	COG3903@1|root,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CbiA,NB-ARC,TIR_2,TPR_10,TPR_12
DYD2_k127_821949_8	439481.Aboo_0416	8.137e-57	216.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,3F2MK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	ribG	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
DYD2_k127_821949_3	861299.J421_6095	4.468e-76	282.0	COG0531@1|root,COG0531@2|Bacteria,1ZUQJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
DYD2_k127_821949_10	1385511.N783_01185	4.651e-56	217.0	COG2936@1|root,COG2936@2|Bacteria,1TT78@1239|Firmicutes,4HBA0@91061|Bacilli	91061|Bacilli	E	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline	pepX	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,PepX_N,Peptidase_S15
DYD2_k127_821949_13	1227500.C494_15268	8.478e-13	81.0	arCOG02542@1|root,arCOG07560@1|root,arCOG02542@2157|Archaea,arCOG07560@2157|Archaea,2Y82Y@28890|Euryarchaeota,24140@183963|Halobacteria	183963|Halobacteria	S	The GLUG motif	-	-	-	-	-	-	-	-	-	-	-	-	Glug
DYD2_k127_821949_1	673860.AciM339_0753	4.537e-114	408.0	COG1287@1|root,arCOG02044@2157|Archaea,arCOG05365@2157|Archaea,2Y7QJ@28890|Euryarchaeota,3F2NE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Carboxypeptidase regulatory-like domain	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	CarboxypepD_reg,PMT_2,STT3
DYD2_k127_821949_7	1236689.MMALV_01410	1.189e-72	256.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,3F2FN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
DYD2_k127_821949_12	1206101.AZXC01000021_gene2176	2.085e-14	85.0	2AQV1@1|root,31G37@2|Bacteria,2IEU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_821949_0	565033.GACE_1941	1.921e-250	790.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,245PD@183980|Archaeoglobi	183980|Archaeoglobi	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
DYD2_k127_840232_7	550540.Fbal_0106	4.437e-07	60.0	COG3468@1|root,COG3468@2|Bacteria,1NTR4@1224|Proteobacteria,1T238@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	Protein of unknown function (DUF3014)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3014
DYD2_k127_840232_2	937777.Deipe_1598	1.035e-56	213.0	COG0382@1|root,COG0382@2|Bacteria,1WI4B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	COGs COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
DYD2_k127_840232_1	1054217.TALC_00144	1.039e-86	301.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,241PQ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
DYD2_k127_840232_5	1041930.Mtc_0041	9.062e-38	163.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota,2N9J3@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GHMP kinase	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
DYD2_k127_840232_3	1454004.AW11_00045	9.397e-51	208.0	COG2202@1|root,COG3452@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3452@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,2WGSC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
DYD2_k127_840232_6	243230.DR_A0049	3.38e-18	98.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
DYD2_k127_840232_4	1236689.MMALV_07810	3.635e-48	184.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,3F2P7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_840232_0	192952.MM_1493	1.235e-144	466.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9G6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
DYD2_k127_847854_4	1071085.KK033114_gene1191	1.382e-51	193.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,23SMM@183963|Halobacteria	183963|Halobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
DYD2_k127_847854_6	273677.BW34_01339	4.606e-47	177.0	COG5637@1|root,COG5637@2|Bacteria,2IN7X@201174|Actinobacteria,4FP2P@85023|Microbacteriaceae	201174|Actinobacteria	S	polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
DYD2_k127_847854_5	546414.Deide_01241	2.748e-47	174.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
DYD2_k127_847854_7	237368.SCABRO_02775	1.299e-12	82.0	COG1361@1|root,COG3023@1|root,COG3064@1|root,COG3266@1|root,COG4412@1|root,COG1361@2|Bacteria,COG3023@2|Bacteria,COG3064@2|Bacteria,COG3266@2|Bacteria,COG4412@2|Bacteria,2J4CI@203682|Planctomycetes	203682|Planctomycetes	MV	Ami_2	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
DYD2_k127_847854_2	521011.Mpal_0423	7.581e-88	322.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
DYD2_k127_847854_1	1496688.ER33_10645	6.423e-108	391.0	COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,22SHW@167375|Cyanobium	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
DYD2_k127_847854_8	237368.SCABRO_02775	9.867e-11	76.0	COG1361@1|root,COG3023@1|root,COG3064@1|root,COG3266@1|root,COG4412@1|root,COG1361@2|Bacteria,COG3023@2|Bacteria,COG3064@2|Bacteria,COG3266@2|Bacteria,COG4412@2|Bacteria,2J4CI@203682|Planctomycetes	203682|Planctomycetes	MV	Ami_2	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
DYD2_k127_847854_3	521011.Mpal_0423	7.348e-63	244.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
DYD2_k127_847854_0	368407.Memar_0730	6.624e-191	608.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
DYD2_k127_858941_10	1459636.NTE_01921	1.272e-49	188.0	COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota	651137|Thaumarchaeota	HK	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
DYD2_k127_858941_16	387631.Asulf_00246	1.137e-32	147.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DYD2_k127_858941_11	1094980.Mpsy_0840	5.399e-48	185.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAGM@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
DYD2_k127_858941_3	1094980.Mpsy_0841	3.274e-153	503.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
DYD2_k127_858941_9	1380354.JIAN01000008_gene3362	9.275e-64	251.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,Malectin,PKD
DYD2_k127_858941_6	1166948.JPZL01000001_gene2640	1.255e-76	269.0	COG4242@1|root,COG4242@2|Bacteria,1PR9J@1224|Proteobacteria,1S6GB@1236|Gammaproteobacteria,1XQTZ@135619|Oceanospirillales	135619|Oceanospirillales	PQ	Peptidase family S51	-	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
DYD2_k127_858941_0	344747.PM8797T_27914	9.767e-265	863.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,2IXGZ@203682|Planctomycetes	203682|Planctomycetes	M	cyanophycin synthetase	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
DYD2_k127_858941_23	1463895.JODA01000022_gene7718	1.235e-05	57.0	COG1361@1|root,COG1361@2|Bacteria,2GMD6@201174|Actinobacteria	201174|Actinobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
DYD2_k127_858941_17	319003.Bra1253DRAFT_08098	2.259e-25	118.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2TU6F@28211|Alphaproteobacteria,3JWM9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
DYD2_k127_858941_8	386456.JQKN01000013_gene3060	1.717e-70	261.0	COG1502@1|root,arCOG02041@2157|Archaea	2157|Archaea	I	Phospholipase D Transphosphatidylase	-	-	-	ko:K06131,ko:K06132,ko:K06915	ko00564,ko01100,map00564,map01100	-	R07390,R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
DYD2_k127_858941_20	68170.KL590490_gene1251	6.631e-09	66.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria,4EDR3@85010|Pseudonocardiales	201174|Actinobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,dCache_1
DYD2_k127_858941_1	1337936.IJ00_01020	1.903e-216	698.0	COG0467@1|root,COG0467@2|Bacteria,1G0KY@1117|Cyanobacteria,1HM2S@1161|Nostocales	1117|Cyanobacteria	F	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
DYD2_k127_858941_19	342113.DM82_134	5.423e-19	100.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,2VIT3@28216|Betaproteobacteria,1K5CY@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
DYD2_k127_858941_12	1267533.KB906739_gene2756	4.044e-47	196.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	divJ	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
DYD2_k127_858941_21	693661.Arcve_1632	2.251e-06	55.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
DYD2_k127_858941_5	693661.Arcve_1631	3.587e-85	295.0	COG0467@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,2XXH5@28890|Euryarchaeota	28890|Euryarchaeota	T	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
DYD2_k127_858941_14	439481.Aboo_0654	6.641e-38	164.0	arCOG00373@1|root,arCOG02452@1|root,arCOG00373@2157|Archaea,arCOG02452@2157|Archaea,2Y71H@28890|Euryarchaeota,3F35U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
DYD2_k127_858941_15	1496688.ER33_01150	8.02e-35	145.0	COG1225@1|root,COG1225@2|Bacteria,1G59X@1117|Cyanobacteria,22SPJ@167375|Cyanobium	1117|Cyanobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
DYD2_k127_858941_25	1455608.JDTH01000001_gene3279	7.465e-05	57.0	COG3413@1|root,arCOG02280@2157|Archaea,2XYE6@28890|Euryarchaeota,23W8G@183963|Halobacteria	183963|Halobacteria	K	GAF and HTH_10 associated domain	-	-	-	-	-	-	-	-	-	-	-	-	BAT,HTH_10
DYD2_k127_858941_24	1077144.AGFF01000017_gene2721	1.734e-05	57.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
DYD2_k127_858941_18	523791.Kkor_1008	5.502e-20	103.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1S07F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
DYD2_k127_858941_7	309800.C498_12848	6.578e-75	267.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota,23SRC@183963|Halobacteria	183963|Halobacteria	S	ATP-NAD AcoX kinase	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
DYD2_k127_858941_2	264732.Moth_1942	3.299e-166	548.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,42FHX@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	Aminotran_5,GDC-P
DYD2_k127_858941_4	756499.Desde_3414	4.1e-113	389.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,2608E@186807|Peptococcaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
DYD2_k127_858941_13	298654.FraEuI1c_2944	2.734e-40	158.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4ESYX@85013|Frankiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
DYD2_k127_858941_22	1278309.KB907099_gene2467	9.789e-06	57.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,1RMQ1@1236|Gammaproteobacteria,1XI1I@135619|Oceanospirillales	135619|Oceanospirillales	L	Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95 C	-	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1
DYD2_k127_864271_2	383372.Rcas_2879	2.772e-156	528.0	COG0236@1|root,COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi,3765Y@32061|Chloroflexia	32061|Chloroflexia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	ko:K15314	ko01059,ko01130,map01059,map01130	M00824,M00825	R11435	-	ko00000,ko00001,ko00002,ko01008	-	-	-	Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
DYD2_k127_864271_4	1484479.DI14_00085	1.033e-58	213.0	COG0623@1|root,COG0623@2|Bacteria,1TPVD@1239|Firmicutes,4H9YN@91061|Bacilli,3WF9W@539002|Bacillales incertae sedis	91061|Bacilli	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
DYD2_k127_864271_0	662479.C440_03158	9.739e-196	624.0	COG4799@1|root,arCOG02705@2157|Archaea,2XSVM@28890|Euryarchaeota,23T6H@183963|Halobacteria	183963|Halobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB2	GO:0003674,GO:0003824,GO:0004658,GO:0016421,GO:0016874,GO:0016885	2.1.3.15,6.4.1.2,6.4.1.3	ko:K19312	ko00280,ko00630,ko00640,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01120,map01130,map01200	M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
DYD2_k127_864271_6	1459636.NTE_02630	1.327e-34	147.0	COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
DYD2_k127_864271_1	246194.CHY_0704	1.517e-178	570.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,42FNV@68295|Thermoanaerobacterales	186801|Clostridia	H	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
DYD2_k127_864271_10	797209.ZOD2009_13616	3.065e-07	63.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_864271_3	290397.Adeh_1665	4.676e-76	271.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YXAE@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
DYD2_k127_864271_5	543526.Htur_0560	4.983e-42	172.0	COG0628@1|root,arCOG02642@2157|Archaea,2XT00@28890|Euryarchaeota,23TDZ@183963|Halobacteria	183963|Halobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
DYD2_k127_864271_7	1094980.Mpsy_1492	9.765e-15	80.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
DYD2_k127_864271_9	348780.NP_4478A	7.297e-10	64.0	COG1534@1|root,arCOG01346@2157|Archaea,2XZWJ@28890|Euryarchaeota,23XQI@183963|Halobacteria	183963|Halobacteria	J	RNA-binding protein containing KH domain, possibly ribosomal protein	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
DYD2_k127_864271_8	595460.RRSWK_07188	2.949e-12	80.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	HEAT_2,Peptidase_M9,Peptidase_M9_N
DYD2_k127_900346_6	673860.AciM339_1313	2.235e-71	252.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,3F32Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
DYD2_k127_900346_4	941824.TCEL_00534	6.767e-104	350.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
DYD2_k127_900346_2	215803.DB30_0768	1.796e-115	381.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,42TDH@68525|delta/epsilon subdivisions,2WIQT@28221|Deltaproteobacteria,2YU5K@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
DYD2_k127_900346_23	66874.JOFS01000007_gene3046	7.579e-11	75.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
DYD2_k127_900346_3	192952.MM_2154	8.187e-107	365.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
DYD2_k127_900346_21	926561.KB900619_gene2349	5.084e-17	93.0	COG3177@1|root,COG3177@2|Bacteria,1TV5J@1239|Firmicutes,24CRC@186801|Clostridia,3WB4E@53433|Halanaerobiales	186801|Clostridia	S	PFAM filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N,HTH_24
DYD2_k127_900346_18	1054217.TALC_01499	1.103e-30	133.0	COG1916@1|root,arCOG02142@2157|Archaea	2157|Archaea	S	homolog of PrgY (pheromone shutdown protein)	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
DYD2_k127_900346_20	1459636.NTE_00536	2.08e-17	89.0	COG0346@1|root,arCOG02708@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
DYD2_k127_900346_1	269797.Mbar_A2101	5.245e-138	463.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
DYD2_k127_900346_9	471854.Dfer_1531	6.27e-62	239.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,4NK9V@976|Bacteroidetes,47MM6@768503|Cytophagia	976|Bacteroidetes	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
DYD2_k127_900346_0	357808.RoseRS_3291	5.159e-226	713.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi,3750V@32061|Chloroflexia	32061|Chloroflexia	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
DYD2_k127_900346_11	717606.PaecuDRAFT_4010	8.676e-54	207.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,26R7Y@186822|Paenibacillaceae	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	-	ko:K13274,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	FlgD_ig,Peptidase_S8,SLH
DYD2_k127_900346_17	1121035.AUCH01000028_gene3254	2.633e-34	151.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,2KVY4@206389|Rhodocyclales	206389|Rhodocyclales	PT	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Hemerythrin,HisKA
DYD2_k127_900346_19	471853.Bcav_1057	1.16e-23	103.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	sdpR	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_900346_14	1210884.HG799471_gene14625	4.168e-41	169.0	COG3832@1|root,COG3832@2|Bacteria,2J16I@203682|Planctomycetes	203682|Planctomycetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
DYD2_k127_900346_15	797299.HALLA_00875	7.25e-39	149.0	COG0640@1|root,arCOG01681@2157|Archaea,2XYB2@28890|Euryarchaeota,23WKI@183963|Halobacteria	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_900346_16	794903.OPIT5_27455	2.382e-38	156.0	COG3832@1|root,COG3832@2|Bacteria,46SRI@74201|Verrucomicrobia,3K9H8@414999|Opitutae	414999|Opitutae	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
DYD2_k127_900346_10	1242864.D187_000385	2.338e-56	201.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,42QW0@68525|delta/epsilon subdivisions,2WMZW@28221|Deltaproteobacteria,2YV61@29|Myxococcales	28221|Deltaproteobacteria	H	3-demethylubiquinone-9 3-methyltransferase	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	3-dmu-9_3-mt
DYD2_k127_900346_13	936136.ARRT01000006_gene4113	3.082e-43	178.0	COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2U7DZ@28211|Alphaproteobacteria,4BFZN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
DYD2_k127_900346_12	1459636.NTE_00447	2.249e-47	186.0	COG3832@1|root,arCOG05261@2157|Archaea	2157|Archaea	H	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
DYD2_k127_900346_7	479432.Sros_0431	1.476e-70	246.0	COG0596@1|root,COG0596@2|Bacteria,2I32Y@201174|Actinobacteria,4ER3J@85012|Streptosporangiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
DYD2_k127_900346_22	797303.Natpe_3373	3.613e-11	76.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota,23V38@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
DYD2_k127_900346_24	523850.TON_1455	1.789e-08	68.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,2440W@183968|Thermococci	183968|Thermococci	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
DYD2_k127_900346_5	439481.Aboo_0657	1.219e-79	273.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,3F2JU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
DYD2_k127_900346_8	1173026.Glo7428_3873	6.888e-64	241.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
DYD2_k127_908178_6	68170.KL590498_gene6766	1.97e-25	114.0	COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria,4E394@85010|Pseudonocardiales	201174|Actinobacteria	S	HAD-hyrolase-like	rifM	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019,ko:K16017	ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130	-	R01334,R06587	RC00017,RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
DYD2_k127_908178_5	591158.SSMG_07053	1.708e-34	145.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria	201174|Actinobacteria	S	CoA-binding	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
DYD2_k127_908178_2	1120973.AQXL01000116_gene325	8.56e-53	207.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,277ZN@186823|Alicyclobacillaceae	91061|Bacilli	O	Belongs to the peptidase S8 family	apr	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
DYD2_k127_908178_4	29540.C481_11655	2.963e-42	180.0	COG0642@1|root,arCOG06796@1|root,arCOG02358@2157|Archaea,arCOG06192@2157|Archaea,arCOG06796@2157|Archaea,2Y7KE@28890|Euryarchaeota,240TZ@183963|Halobacteria	183963|Halobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4
DYD2_k127_908178_3	1229909.NSED_01550	1.865e-49	183.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
DYD2_k127_908178_0	290397.Adeh_3668	2.3e-78	279.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,42UIK@68525|delta/epsilon subdivisions,2X5D2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
DYD2_k127_908178_7	1114856.C496_09681	2.34e-24	111.0	COG4347@1|root,arCOG02940@2157|Archaea,2XTV6@28890|Euryarchaeota,23UNZ@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1405
DYD2_k127_908178_1	1089551.KE386572_gene1743	3.206e-75	289.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
DYD2_k127_967730_1	926690.KE386573_gene2140	1.857e-16	90.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7G0@28890|Euryarchaeota,23Z51@183963|Halobacteria	183963|Halobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
DYD2_k127_967730_2	246197.MXAN_2629	8.492e-08	63.0	COG0457@1|root,COG1716@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,1NNRP@1224|Proteobacteria,438JM@68525|delta/epsilon subdivisions,2X3UA@28221|Deltaproteobacteria,2YX4G@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	k9ap1	-	-	-	-	-	-	-	-	-	-	-	FHA
DYD2_k127_967730_0	365046.Rta_11450	1.899e-23	102.0	COG2755@1|root,COG2755@2|Bacteria,1NT43@1224|Proteobacteria,2W04A@28216|Betaproteobacteria	28216|Betaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
## 2271 queries scanned
## Total time (seconds): 6.147240161895752
## Rate: 369.43 q/s