## Wed Oct 16 10:30:28 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/EH1_bin.4.fa -m mmseqs --itype genome -o EH1_bin.4 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/EH1_bin.4 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
EH1_k127_1026075_5	264731.PRU_0532	5.693e-19	98.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA,AAA_32,AAA_5,CHAT,Lon_C,NB-ARC,TPR_12
EH1_k127_1026075_3	1349822.NSB1T_02890	7.126e-31	140.0	COG2304@1|root,COG2304@2|Bacteria,4P02M@976|Bacteroidetes,2FX22@200643|Bacteroidia	976|Bacteroidetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
EH1_k127_1026075_2	1121468.AUBR01000002_gene664	4.375e-97	326.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,42EK7@68295|Thermoanaerobacterales	186801|Clostridia	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	nfnA	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
EH1_k127_1026075_0	246194.CHY_1991	1.366e-192	612.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
EH1_k127_1026075_1	444157.Tneu_1126	3.589e-112	381.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
EH1_k127_1026075_4	192952.MM_0598	6.224e-24	113.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
EH1_k127_1026075_7	644281.MFS40622_1647	4.907e-06	58.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23R2U@183939|Methanococci	183939|Methanococci	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
EH1_k127_1026075_6	694429.Pyrfu_0380	3.947e-18	87.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
EH1_k127_1032132_1	88036.EFJ13820	2.319e-27	113.0	COG4354@1|root,KOG2119@2759|Eukaryota,37JKE@33090|Viridiplantae,3GEGI@35493|Streptophyta	35493|Streptophyta	G	Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide	-	-	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
EH1_k127_1032132_0	877455.Metbo_0444	2.235e-35	150.0	COG2232@1|root,arCOG01595@2157|Archaea,2XVAH@28890|Euryarchaeota,23P2I@183925|Methanobacteria	183925|Methanobacteria	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
EH1_k127_1032132_2	90675.XP_010475384.1	0.000251	53.0	2A1JH@1|root,2RY0Y@2759|Eukaryota,37U8E@33090|Viridiplantae,3GMDX@35493|Streptophyta,3HY58@3699|Brassicales	35493|Streptophyta	S	mitochondrion organization	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005773,GO:0005774,GO:0006996,GO:0007005,GO:0008150,GO:0009536,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031306,GO:0031307,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0032592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044437,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0071840,GO:0098573,GO:0098588,GO:0098805	-	ko:K10374	ko04260,ko04261,ko05410,ko05414,map04260,map04261,map05410,map05414	-	-	-	ko00000,ko00001,ko04812	-	-	-	-
EH1_k127_1043019_8	886293.Sinac_6723	1.78e-18	90.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
EH1_k127_1043019_1	118173.KB235910_gene4790	7.23e-67	243.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
EH1_k127_1043019_5	1304880.JAGB01000001_gene867	1.776e-30	134.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
EH1_k127_1043019_0	1125863.JAFN01000001_gene2593	2.469e-103	351.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH1_k127_1043019_11	7213.XP_004534456.1	2.298e-07	64.0	COG4886@1|root,KOG0619@2759|Eukaryota,38GJI@33154|Opisthokonta,3BF9C@33208|Metazoa,3CYMA@33213|Bilateria,427H6@6656|Arthropoda,3SQBS@50557|Insecta,45012@7147|Diptera	33208|Metazoa	T	Leucine Rich Repeat	IGFALS	GO:0003674,GO:0005488,GO:0005515,GO:0005520,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006807,GO:0007154,GO:0007165,GO:0007568,GO:0008150,GO:0008152,GO:0009410,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0014070,GO:0016942,GO:0019538,GO:0019838,GO:0023052,GO:0031667,GO:0031960,GO:0031974,GO:0031981,GO:0032502,GO:0032870,GO:0032991,GO:0033993,GO:0034097,GO:0035690,GO:0036454,GO:0042221,GO:0042493,GO:0042567,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043434,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0048545,GO:0050789,GO:0050794,GO:0050896,GO:0051384,GO:0051716,GO:0060416,GO:0065007,GO:0070013,GO:0070555,GO:0070848,GO:0070849,GO:0070887,GO:0071310,GO:0071345,GO:0071347,GO:0071363,GO:0071364,GO:0071375,GO:0071378,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0097327,GO:1901564,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701	-	ko:K17256	-	-	-	-	ko00000,ko04147	-	-	-	LRRNT,LRR_8
EH1_k127_1043019_4	105420.BBPO01000031_gene6590	2.475e-33	134.0	COG0789@1|root,COG0789@2|Bacteria,2IC98@201174|Actinobacteria,2NGH2@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
EH1_k127_1043019_10	368407.Memar_2368	8.913e-09	62.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2NA25@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
EH1_k127_1043019_3	693661.Arcve_0056	4.978e-41	157.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
EH1_k127_1043019_7	1408422.JHYF01000004_gene1563	3.423e-19	92.0	COG0346@1|root,COG0346@2|Bacteria,1VC53@1239|Firmicutes,24ICT@186801|Clostridia,36IP2@31979|Clostridiaceae	186801|Clostridia	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
EH1_k127_1043019_9	279010.BL02656	1.836e-10	68.0	COG2318@1|root,COG2318@2|Bacteria,1V6FD@1239|Firmicutes,4HJI8@91061|Bacilli	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
EH1_k127_1043019_2	1220534.B655_0706	1.269e-61	218.0	COG4832@1|root,arCOG03201@2157|Archaea,2Y3NU@28890|Euryarchaeota	28890|Euryarchaeota	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
EH1_k127_1043019_12	673860.AciM339_1288	0.0008427	51.0	arCOG02499@1|root,arCOG02499@2157|Archaea,2Y6YI@28890|Euryarchaeota,3F2WY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
EH1_k127_1043019_6	1151292.QEW_3935	1.356e-25	115.0	COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,25R3U@186804|Peptostreptococcaceae	186801|Clostridia	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
EH1_k127_1051599_0	349161.Dred_2982	1.026e-207	674.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
EH1_k127_1081706_3	1499967.BAYZ01000158_gene435	4.951e-70	256.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	thiP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	iAPECO1_1312.APECO1_1915,iECIAI1_1343.ECIAI1_0067,iECO103_1326.ECO103_0068,iECO111_1330.ECO111_0069,iECO26_1355.ECO26_0069,iECOK1_1307.ECOK1_0068,iECS88_1305.ECS88_0072,iECSE_1348.ECSE_0067,iECUMN_1333.ECUMN_0068,iPC815.YPO0521,iSF_1195.SF0062,iSFxv_1172.SFxv_0064,iS_1188.S0064,iUMN146_1321.UM146_23130,iUTI89_1310.UTI89_C0075	BPD_transp_1
EH1_k127_1081706_2	997346.HMPREF9374_2152	7.824e-74	261.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4H9MS@91061|Bacilli,27CNS@186824|Thermoactinomycetaceae	91061|Bacilli	P	TOBE domain	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
EH1_k127_1081706_4	596320.NEIFL0001_1821	5.509e-10	65.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,2VTV9@28216|Betaproteobacteria,2KREG@206351|Neisseriales	206351|Neisseriales	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
EH1_k127_1081706_0	186497.PF1497	1.043e-141	461.0	COG0436@1|root,arCOG01131@2157|Archaea,2XVXM@28890|Euryarchaeota,243JD@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
EH1_k127_1081706_1	694429.Pyrfu_0111	7.672e-110	364.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
EH1_k127_1083288_0	1121422.AUMW01000011_gene93	3.761e-90	310.0	COG2070@1|root,COG2070@2|Bacteria,1VTQJ@1239|Firmicutes,24ZN0@186801|Clostridia,26495@186807|Peptococcaceae	186801|Clostridia	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
EH1_k127_1083288_1	589924.Ferp_1486	6.076e-31	127.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota,2468P@183980|Archaeoglobi	183980|Archaeoglobi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_1083288_3	886293.Sinac_5517	3.664e-05	51.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2IYZ1@203682|Planctomycetes	203682|Planctomycetes	A	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
EH1_k127_1083288_2	693661.Arcve_0051	9.598e-06	50.0	COG2414@1|root,arCOG00706@2157|Archaea,2XUYU@28890|Euryarchaeota,246KA@183980|Archaeoglobi	183980|Archaeoglobi	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_1084021_1	269797.Mbar_A0976	5.396e-07	61.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
EH1_k127_1084021_0	913865.DOT_0089	2.584e-31	128.0	COG0509@1|root,COG0509@2|Bacteria,1V9VC@1239|Firmicutes,24QN1@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
EH1_k127_1084021_2	439481.Aboo_0624	6.785e-05	48.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y76C@28890|Euryarchaeota,3F3GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1111318_0	224325.AF_2100	2.279e-109	361.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,245VB@183980|Archaeoglobi	28890|Euryarchaeota	E	Acetolactate synthase, large subunit	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
EH1_k127_1111318_2	706587.Desti_0748	2.824e-66	238.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WQY2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
EH1_k127_1111318_6	1463903.JOIZ01000003_gene1743	9.326e-12	71.0	COG3255@1|root,COG3255@2|Bacteria	2|Bacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_1111318_3	926560.KE387027_gene410	4.204e-25	109.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	ywlB	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,C_GCAxxG_C_C
EH1_k127_1111318_1	552811.Dehly_1422	8.985e-67	239.0	COG0500@1|root,COG2226@2|Bacteria,2G6GD@200795|Chloroflexi,34CS0@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
EH1_k127_1111318_5	386456.JQKN01000016_gene928	3.934e-19	93.0	COG1695@1|root,arCOG00001@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
EH1_k127_1111318_4	717774.Marme_2202	8.249e-21	104.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	BBE,FAD_binding_4
EH1_k127_1131955_0	1254432.SCE1572_28075	5.575e-08	64.0	COG5555@1|root,COG5555@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
EH1_k127_1169107_0	397948.Cmaq_0938	7.31e-131	443.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
EH1_k127_1169107_1	593117.TGAM_2149	5.924e-88	296.0	COG0110@1|root,arCOG01848@2157|Archaea,2XWJM@28890|Euryarchaeota,242NY@183968|Thermococci	183968|Thermococci	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
EH1_k127_1169107_2	269797.Mbar_A0890	1.194e-45	172.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
EH1_k127_1191474_3	1220534.B655_0260	6.654e-42	160.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,23NXA@183925|Methanobacteria	183925|Methanobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH1_k127_1191474_4	1042877.GQS_07300	1.641e-41	159.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,243AW@183968|Thermococci	183968|Thermococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
EH1_k127_1191474_5	877455.Metbo_0588	7.944e-21	102.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23NZU@183925|Methanobacteria	183925|Methanobacteria	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
EH1_k127_1191474_9	1343739.PAP_03590	0.0003438	51.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,242JN@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1191474_1	1042877.GQS_10350	8.321e-131	441.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
EH1_k127_1191474_8	633148.Tagg_0170	6.118e-10	65.0	COG0550@1|root,arCOG01527@2157|Archaea,2XQ00@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA topoisomerase, type IA, central domain protein	topA	-	5.99.1.2	ko:K03168,ko:K03169	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
EH1_k127_1191474_0	1343739.PAP_05975	2.924e-158	523.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
EH1_k127_1191474_2	604354.TSIB_1050	1.175e-46	176.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,24344@183968|Thermococci	183968|Thermococci	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
EH1_k127_1191474_7	756499.Desde_0119	2.907e-11	71.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,260AI@186807|Peptococcaceae	186801|Clostridia	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
EH1_k127_1191474_6	246969.TAM4_1536	2.12e-13	78.0	COG0294@1|root,arCOG02817@2157|Archaea,2Y2MG@28890|Euryarchaeota,245DE@183968|Thermococci	183968|Thermococci	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
EH1_k127_1201957_1	439481.Aboo_0845	4.551e-110	366.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
EH1_k127_1201957_0	1184251.TCELL_1162	2.917e-115	387.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH1_k127_1201957_2	1200792.AKYF01000010_gene1767	4.445e-32	141.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HA7I@91061|Bacilli,26QGW@186822|Paenibacillaceae	91061|Bacilli	P	Peptide ABC transporter permease	oppC1	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH1_k127_1269916_3	1340434.AXVA01000007_gene5007	4.461e-10	74.0	COG5434@1|root,COG5434@2|Bacteria,1VC1X@1239|Firmicutes,4HN4P@91061|Bacilli,1ZHEU@1386|Bacillus	91061|Bacilli	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
EH1_k127_1269916_2	1094980.Mpsy_0032	3.507e-13	85.0	COG4870@1|root,arCOG02501@1|root,arCOG02542@1|root,arCOG02501@2157|Archaea,arCOG02542@2157|Archaea,arCOG03607@2157|Archaea,2Y0FJ@28890|Euryarchaeota,2NB7C@224756|Methanomicrobia	28890|Euryarchaeota	O	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD
EH1_k127_1269916_1	224325.AF_0578	1.429e-15	81.0	COG2234@1|root,arCOG02962@2157|Archaea	2157|Archaea	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
EH1_k127_1269916_0	224325.AF_0578	1.58e-21	100.0	COG2234@1|root,arCOG02962@2157|Archaea	2157|Archaea	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
EH1_k127_1275324_5	1385935.N836_04355	6.607e-06	51.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA
EH1_k127_1275324_2	768672.Desfe_0703	1.618e-28	120.0	arCOG00022@1|root,arCOG00022@2157|Archaea,2XQTH@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
EH1_k127_1275324_4	1216932.CM240_1289	2.635e-08	58.0	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,36N2I@31979|Clostridiaceae	186801|Clostridia	O	glutaredoxin-like protein, YruB-family	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
EH1_k127_1275324_0	1163730.FFONT_1179	3.299e-66	237.0	COG0492@1|root,arCOG01296@2157|Archaea,2XPQC@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
EH1_k127_1275324_1	880073.Calab_1228	1.145e-48	181.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
EH1_k127_1275324_3	7029.ACYPI55414-PA	8.532e-11	73.0	COG4886@1|root,KOG0619@2759|Eukaryota,38GPY@33154|Opisthokonta,3BFMX@33208|Metazoa,3CS8Y@33213|Bilateria,41TJ5@6656|Arthropoda,3SHWZ@50557|Insecta,3E9P4@33342|Paraneoptera	33208|Metazoa	S	Leucine Rich Repeat	GPRNNB1	-	-	ko:K17256	-	-	-	-	ko00000,ko04147	-	-	-	LRR_1,LRR_5,LRR_6,LRR_8
EH1_k127_1298654_1	68170.KL590490_gene1267	1.187e-37	168.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
EH1_k127_1298654_0	234267.Acid_2341	1.193e-47	201.0	COG3055@1|root,COG5306@1|root,COG3055@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,Malectin,MotA_ExbB
EH1_k127_1392113_3	235985.BBPN01000004_gene3180	2.006e-36	143.0	COG0388@1|root,COG0388@2|Bacteria,2GP6F@201174|Actinobacteria,2NF26@228398|Streptacidiphilus	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
EH1_k127_1392113_5	797209.ZOD2009_02605	1.642e-17	97.0	COG2234@1|root,arCOG02959@2157|Archaea,2XU4X@28890|Euryarchaeota,23T0D@183963|Halobacteria	183963|Halobacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
EH1_k127_1392113_0	204669.Acid345_1532	3.538e-122	405.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria,2JKID@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
EH1_k127_1392113_6	694429.Pyrfu_0792	1.805e-15	90.0	COG4882@1|root,arCOG02960@2157|Archaea,2XQU8@28889|Crenarchaeota	28889|Crenarchaeota	S	Aminopeptidase Iap family-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
EH1_k127_1392113_2	880073.Calab_1834	9.899e-38	154.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
EH1_k127_1392113_4	1123360.thalar_02215	6.055e-30	137.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_1392113_1	1304874.JAFY01000002_gene135	1.526e-77	277.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH1_k127_1393344_2	1191523.MROS_1829	8.661e-61	219.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
EH1_k127_1393344_4	404589.Anae109_1562	0.0006156	49.0	COG0454@1|root,COG0456@2|Bacteria,1Q1ZZ@1224|Proteobacteria,42USA@68525|delta/epsilon subdivisions,2WQ2Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_1393344_0	1123274.KB899432_gene2914	8.159e-75	264.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
EH1_k127_1393344_3	5888.CAK64894	1.185e-12	80.0	COG0457@1|root,COG3914@1|root,KOG0553@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
EH1_k127_1393344_1	1094980.Mpsy_3151	6.423e-63	241.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1429906_0	889378.Spiaf_0466	8.816e-70	249.0	COG2017@1|root,COG2017@2|Bacteria,2J5MM@203691|Spirochaetes	203691|Spirochaetes	G	Converts alpha-aldose to the beta-anomer	galM	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
EH1_k127_1429906_2	268407.PWYN_19130	9.934e-63	225.0	COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes,4HB4C@91061|Bacilli,2777Z@186822|Paenibacillaceae	91061|Bacilli	E	YoaP-like	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
EH1_k127_1429906_1	102129.Lepto7375DRAFT_6665	8.008e-63	233.0	COG3214@1|root,COG3214@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	ycaQ	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
EH1_k127_1429906_3	479434.Sthe_3281	1.424e-62	226.0	COG0726@1|root,COG0726@2|Bacteria,2GB8A@200795|Chloroflexi,27XZW@189775|Thermomicrobia	189775|Thermomicrobia	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
EH1_k127_1429906_4	1128398.Curi_c20070	6.042e-62	222.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,24BBC@186801|Clostridia,26B60@186813|unclassified Clostridiales	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	fabG4	-	1.1.1.100,1.1.1.304,1.1.1.385,1.1.1.76	ko:K00059,ko:K18009,ko:K19548	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572,M00787	R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R10917,R11671	RC00029,RC00117,RC00154,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH1_k127_1429906_6	1209984.BN978_06119	1.21e-21	108.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,2360Z@1762|Mycobacteriaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
EH1_k127_1429906_5	1261545.MBE-HAL_1992	1.051e-50	205.0	COG2203@1|root,arCOG02387@1|root,arCOG02369@2157|Archaea,arCOG02387@2157|Archaea,2Y149@28890|Euryarchaeota,240V2@183963|Halobacteria	183963|Halobacteria	T	COG0784 FOG CheY-like receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,Response_reg
EH1_k127_1429906_7	1068978.AMETH_5376	7.484e-05	49.0	COG2072@1|root,COG2072@2|Bacteria,2GK95@201174|Actinobacteria,4DZU3@85010|Pseudonocardiales	201174|Actinobacteria	P	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_3
EH1_k127_1435406_0	1235802.C823_02093	0.0001055	55.0	COG2159@1|root,COG2159@2|Bacteria,1TSSX@1239|Firmicutes,258XA@186801|Clostridia,25Z35@186806|Eubacteriaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
EH1_k127_144617_3	1459636.NTE_01818	1.944e-14	79.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
EH1_k127_144617_1	416348.Hlac_3585	3.502e-22	101.0	COG1487@1|root,arCOG02219@2157|Archaea,2XX7I@28890|Euryarchaeota,23VMN@183963|Halobacteria	183963|Halobacteria	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
EH1_k127_144617_2	416348.Hlac_1432	6.484e-15	77.0	arCOG08146@1|root,arCOG08146@2157|Archaea,2XZH2@28890|Euryarchaeota,23X8V@183963|Halobacteria	183963|Halobacteria	K	Putative antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
EH1_k127_144617_4	694429.Pyrfu_0610	4.218e-11	69.0	COG2402@1|root,arCOG04502@2157|Archaea,2XSKX@28889|Crenarchaeota	28889|Crenarchaeota	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
EH1_k127_144617_0	228405.HNE_1608	5.664e-55	204.0	COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,2U1GN@28211|Alphaproteobacteria,43X4A@69657|Hyphomonadaceae	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
EH1_k127_1473467_0	237368.SCABRO_02433	1.583e-52	199.0	COG0123@1|root,COG0123@2|Bacteria,2IXK9@203682|Planctomycetes	203682|Planctomycetes	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
EH1_k127_1473467_1	999630.TUZN_1379	1.491e-22	112.0	COG1746@1|root,arCOG04249@2157|Archaea,2XQ3X@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
EH1_k127_1478094_0	926554.KI912660_gene2395	2.069e-47	179.0	COG0318@1|root,COG0318@2|Bacteria,1WIAG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
EH1_k127_1478094_1	768704.Desmer_0945	3.905e-23	106.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,262Q4@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
EH1_k127_1522553_3	643648.Slip_0678	7.699e-08	56.0	COG0491@1|root,COG0491@2|Bacteria,1UZUA@1239|Firmicutes,24CIA@186801|Clostridia,42KG0@68298|Syntrophomonadaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_1522553_0	945713.IALB_0605	1.759e-44	176.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
EH1_k127_1522553_1	743525.TSC_c09700	1.127e-34	143.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
EH1_k127_1522553_2	768679.TTX_0331	1.95e-32	131.0	COG1402@1|root,arCOG04536@2157|Archaea,2XQVG@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
EH1_k127_153479_6	439481.Aboo_1449	1.937e-49	180.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,3F2RN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
EH1_k127_153479_4	634498.mru_0618	2.08e-69	246.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
EH1_k127_153479_11	1121481.AUAS01000001_gene4502	0.0008576	48.0	COG3118@1|root,COG3118@2|Bacteria,4NS6N@976|Bacteroidetes,47R18@768503|Cytophagia	976|Bacteroidetes	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
EH1_k127_153479_3	880072.Desac_1236	5.214e-76	263.0	COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,42NT2@68525|delta/epsilon subdivisions,2WJM5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Mediates zinc uptake. May also transport other divalent cations	gufA	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
EH1_k127_153479_10	9823.ENSSSCP00000009606	1.619e-05	56.0	COG4886@1|root,KOG4641@2759|Eukaryota,38EEZ@33154|Opisthokonta,3BFZ2@33208|Metazoa,3D3KM@33213|Bilateria,488PE@7711|Chordata,497CK@7742|Vertebrata,3JEB1@40674|Mammalia,4J42B@91561|Cetartiodactyla	33208|Metazoa	T	toll-like receptor	TLR2	GO:0001101,GO:0001505,GO:0001530,GO:0001540,GO:0001774,GO:0001775,GO:0001816,GO:0001817,GO:0001818,GO:0001819,GO:0001875,GO:0001932,GO:0001934,GO:0002218,GO:0002220,GO:0002221,GO:0002224,GO:0002237,GO:0002238,GO:0002252,GO:0002253,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002367,GO:0002374,GO:0002376,GO:0002429,GO:0002440,GO:0002443,GO:0002444,GO:0002446,GO:0002520,GO:0002521,GO:0002573,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002703,GO:0002718,GO:0002720,GO:0002730,GO:0002752,GO:0002755,GO:0002757,GO:0002758,GO:0002764,GO:0002768,GO:0002790,GO:0002791,GO:0002793,GO:0002831,GO:0002833,GO:0003008,GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0006082,GO:0006355,GO:0006357,GO:0006464,GO:0006468,GO:0006690,GO:0006691,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006915,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007154,GO:0007165,GO:0007166,GO:0007249,GO:0007252,GO:0007272,GO:0007275,GO:0007399,GO:0007417,GO:0007610,GO:0007611,GO:0007612,GO:0008064,GO:0008104,GO:0008150,GO:0008152,GO:0008219,GO:0008285,GO:0008289,GO:0008329,GO:0008366,GO:0009306,GO:0009593,GO:0009595,GO:0009605,GO:0009607,GO:0009617,GO:0009620,GO:0009653,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009896,GO:0009897,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010001,GO:0010033,GO:0010243,GO:0010468,GO:0010506,GO:0010508,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010628,GO:0010639,GO:0010646,GO:0010647,GO:0010720,GO:0010927,GO:0010935,GO:0012501,GO:0012505,GO:0012506,GO:0014003,GO:0014004,GO:0014005,GO:0014013,GO:0014015,GO:0015031,GO:0015791,GO:0015833,GO:0015850,GO:0015893,GO:0016020,GO:0016021,GO:0016043,GO:0016045,GO:0016192,GO:0016239,GO:0016241,GO:0016310,GO:0017144,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019752,GO:0021782,GO:0022008,GO:0022010,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0030097,GO:0030099,GO:0030100,GO:0030111,GO:0030141,GO:0030154,GO:0030177,GO:0030225,GO:0030334,GO:0030335,GO:0030659,GO:0030667,GO:0030832,GO:0030833,GO:0030837,GO:0031090,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031331,GO:0031333,GO:0031347,GO:0031349,GO:0031399,GO:0031401,GO:0031410,GO:0031663,GO:0031982,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032271,GO:0032272,GO:0032288,GO:0032289,GO:0032291,GO:0032479,GO:0032481,GO:0032490,GO:0032493,GO:0032494,GO:0032496,GO:0032501,GO:0032502,GO:0032535,GO:0032613,GO:0032640,GO:0032642,GO:0032648,GO:0032651,GO:0032652,GO:0032653,GO:0032655,GO:0032660,GO:0032661,GO:0032675,GO:0032677,GO:0032680,GO:0032695,GO:0032700,GO:0032722,GO:0032728,GO:0032731,GO:0032732,GO:0032733,GO:0032735,GO:0032741,GO:0032755,GO:0032757,GO:0032760,GO:0032879,GO:0032880,GO:0032940,GO:0032956,GO:0032970,GO:0032989,GO:0032991,GO:0033036,GO:0033043,GO:0033218,GO:0033993,GO:0034097,GO:0034121,GO:0034123,GO:0034134,GO:0034341,GO:0035325,GO:0035354,GO:0035355,GO:0035556,GO:0035821,GO:0036211,GO:0036230,GO:0038023,GO:0038123,GO:0038124,GO:0038187,GO:0040008,GO:0040012,GO:0040017,GO:0042035,GO:0042063,GO:0042108,GO:0042116,GO:0042119,GO:0042127,GO:0042133,GO:0042221,GO:0042277,GO:0042325,GO:0042327,GO:0042493,GO:0042494,GO:0042495,GO:0042496,GO:0042497,GO:0042498,GO:0042534,GO:0042535,GO:0042552,GO:0042742,GO:0042802,GO:0042834,GO:0042886,GO:0042891,GO:0042892,GO:0042995,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043235,GO:0043254,GO:0043299,GO:0043312,GO:0043408,GO:0043410,GO:0043412,GO:0043436,GO:0043900,GO:0043901,GO:0043902,GO:0043903,GO:0044003,GO:0044085,GO:0044087,GO:0044093,GO:0044126,GO:0044130,GO:0044144,GO:0044146,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044297,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044877,GO:0045055,GO:0045087,GO:0045088,GO:0045089,GO:0045121,GO:0045184,GO:0045321,GO:0045428,GO:0045429,GO:0045595,GO:0045597,GO:0045685,GO:0045687,GO:0045806,GO:0045893,GO:0045926,GO:0045935,GO:0045937,GO:0045944,GO:0046209,GO:0046903,GO:0046982,GO:0046983,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048583,GO:0048584,GO:0048646,GO:0048699,GO:0048709,GO:0048713,GO:0048714,GO:0048731,GO:0048856,GO:0048869,GO:0050663,GO:0050704,GO:0050706,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050716,GO:0050718,GO:0050727,GO:0050729,GO:0050764,GO:0050765,GO:0050767,GO:0050769,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050807,GO:0050830,GO:0050877,GO:0050890,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051051,GO:0051090,GO:0051091,GO:0051092,GO:0051093,GO:0051094,GO:0051128,GO:0051129,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051252,GO:0051254,GO:0051270,GO:0051272,GO:0051493,GO:0051494,GO:0051606,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051769,GO:0051770,GO:0051817,GO:0051960,GO:0051961,GO:0051962,GO:0051963,GO:0051964,GO:0052031,GO:0052063,GO:0052163,GO:0052173,GO:0052200,GO:0052251,GO:0052255,GO:0052263,GO:0052302,GO:0052345,GO:0052347,GO:0052509,GO:0052510,GO:0052551,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052558,GO:0052559,GO:0052564,GO:0052565,GO:0052572,GO:0060089,GO:0060255,GO:0060284,GO:0060627,GO:0060759,GO:0060760,GO:0060907,GO:0061081,GO:0061515,GO:0061900,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070339,GO:0070340,GO:0070372,GO:0070374,GO:0070391,GO:0070542,GO:0070887,GO:0070891,GO:0071216,GO:0071219,GO:0071220,GO:0071221,GO:0071222,GO:0071223,GO:0071224,GO:0071310,GO:0071345,GO:0071346,GO:0071396,GO:0071417,GO:0071495,GO:0071702,GO:0071704,GO:0071705,GO:0071706,GO:0071723,GO:0071724,GO:0071725,GO:0071726,GO:0071727,GO:0071840,GO:0071944,GO:0072593,GO:0075136,GO:0080090,GO:0080134,GO:0090066,GO:0090087,GO:0097367,GO:0097708,GO:0098542,GO:0098543,GO:0098552,GO:0098581,GO:0098588,GO:0098589,GO:0098796,GO:0098797,GO:0098802,GO:0098805,GO:0098857,GO:0099503,GO:0110053,GO:1901222,GO:1901224,GO:1901564,GO:1901568,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533,GO:1902680,GO:1902903,GO:1902904,GO:1903426,GO:1903428,GO:1903506,GO:1903508,GO:1903530,GO:1903532,GO:1903555,GO:1903557,GO:1903969,GO:1903971,GO:1903972,GO:1903974,GO:1904407,GO:1904415,GO:1904417,GO:1904467,GO:1904469,GO:1904951,GO:1905809,GO:2000026,GO:2000112,GO:2000145,GO:2000147,GO:2000377,GO:2000379,GO:2000482,GO:2000484,GO:2001057,GO:2001141	-	ko:K10159	ko04145,ko04151,ko04620,ko05134,ko05140,ko05142,ko05144,ko05145,ko05146,ko05152,ko05161,ko05162,ko05168,ko05205,ko05321,ko05323,map04145,map04151,map04620,map05134,map05140,map05142,map05144,map05145,map05146,map05152,map05161,map05162,map05168,map05205,map05321,map05323	M00686	-	-	ko00000,ko00001,ko00002,ko00536,ko04090,ko04131,ko04147	-	-	-	LRRCT,LRR_4,LRR_6,LRR_8,TIR
EH1_k127_153479_8	112098.XP_008619955.1	6.363e-26	115.0	COG0622@1|root,KOG3325@2759|Eukaryota	2759|Eukaryota	IQ	retrograde transport, endosome to Golgi	VPS29	GO:0000139,GO:0000323,GO:0001881,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005767,GO:0005768,GO:0005770,GO:0005771,GO:0005773,GO:0005794,GO:0005802,GO:0005829,GO:0006605,GO:0006623,GO:0006810,GO:0006886,GO:0006892,GO:0006896,GO:0007034,GO:0008104,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010008,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016192,GO:0016197,GO:0016482,GO:0023051,GO:0030139,GO:0030904,GO:0030906,GO:0031090,GO:0031410,GO:0031902,GO:0031982,GO:0031984,GO:0032009,GO:0032010,GO:0032588,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042147,GO:0042886,GO:0043112,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044260,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045335,GO:0046872,GO:0046907,GO:0046914,GO:0048193,GO:0050789,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0065007,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0072594,GO:0072665,GO:0072666,GO:0097708,GO:0098588,GO:0098791,GO:0098796,GO:0098805,GO:0098876,GO:1990126	-	ko:K07095,ko:K18467	ko04144,map04144	-	-	-	ko00000,ko00001,ko04131	-	-	-	Metallophos_2
EH1_k127_153479_1	1041930.Mtc_1125	3.733e-121	417.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
EH1_k127_153479_0	368408.Tpen_0817	1.119e-156	509.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
EH1_k127_153479_7	693661.Arcve_2003	5.881e-44	166.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,246YM@183980|Archaeoglobi	183980|Archaeoglobi	F	Nicotinamide-nucleotide adenylyltransferase	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
EH1_k127_153479_2	572478.Vdis_1705	6.076e-107	357.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
EH1_k127_153479_5	439481.Aboo_0093	8.302e-66	238.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,3F2J9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Nucleolar GTP-binding protein 1 (NOG1)	gbp4	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
EH1_k127_153479_9	339860.Msp_0282	1.354e-24	108.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23NYV@183925|Methanobacteria	183925|Methanobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
EH1_k127_1550913_4	224325.AF_0367	4.278e-25	107.0	COG0477@1|root,arCOG00147@2157|Archaea,2XTS8@28890|Euryarchaeota,246N5@183980|Archaeoglobi	183980|Archaeoglobi	G	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
EH1_k127_1550913_0	1038858.AXBA01000012_gene1804	3.289e-241	762.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,3EYAB@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
EH1_k127_1550913_2	1304874.JAFY01000002_gene895	2.505e-109	365.0	COG0624@1|root,COG0624@2|Bacteria,3TBDJ@508458|Synergistetes	508458|Synergistetes	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
EH1_k127_1550913_1	1365176.N186_07015	1.681e-199	636.0	COG0504@1|root,arCOG00063@2157|Archaea,2XPKS@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
EH1_k127_1550913_3	224325.AF_1060	1.059e-53	207.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,246V1@183980|Archaeoglobi	183980|Archaeoglobi	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
EH1_k127_1557454_4	509191.AEDB02000094_gene4210	2.391e-26	117.0	COG5418@1|root,COG5418@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
EH1_k127_1557454_6	304371.MCP_1363	2.224e-05	55.0	COG2314@1|root,arCOG07221@1|root,arCOG03293@2157|Archaea,arCOG07221@2157|Archaea,2XYU1@28890|Euryarchaeota	28890|Euryarchaeota	T	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3,zinc_ribbon_2
EH1_k127_1557454_1	690850.Desaf_2977	2.219e-79	271.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2M9ST@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
EH1_k127_1557454_5	589924.Ferp_1318	1.056e-14	84.0	COG1600@1|root,arCOG02740@2157|Archaea,2XVBB@28890|Euryarchaeota,245SR@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S double cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_16
EH1_k127_1557454_0	1280692.AUJL01000011_gene3155	2.313e-135	447.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,36FKP@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0371 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
EH1_k127_1557454_3	646529.Desaci_0681	1.222e-27	120.0	COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes	1239|Firmicutes	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
EH1_k127_1557454_2	1137799.GZ78_17415	8.515e-53	197.0	COG1305@1|root,COG1305@2|Bacteria,1R9WH@1224|Proteobacteria,1SCP4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
EH1_k127_1572685_1	557599.MKAN_03715	1.112e-73	267.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
EH1_k127_1572685_2	557599.MKAN_03715	7.063e-69	246.0	COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae	201174|Actinobacteria	EGH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.399,1.1.1.95,2.7.1.189	ko:K00058,ko:K11216	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024	M00020	R01513,R11183	RC00002,RC00017,RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2
EH1_k127_1572685_3	446470.Snas_4442	0.0001034	49.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4EYT8@85014|Glycomycetales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_1625405_0	186497.PF1920	1.758e-81	277.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
EH1_k127_1625405_1	573064.Mefer_0477	5.259e-53	198.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23QKP@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
EH1_k127_1625405_6	658655.HMPREF0988_00346	3.808e-08	64.0	COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,248Q2@186801|Clostridia,27J3D@186928|unclassified Lachnospiraceae	186801|Clostridia	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
EH1_k127_1625405_2	574376.BAMA_02295	3.378e-38	159.0	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,4HA5I@91061|Bacilli,1ZBZE@1386|Bacillus	91061|Bacilli	E	COG0006 Xaa-Pro aminopeptidase	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
EH1_k127_1625405_3	1121927.GOHSU_17_00380	1.91e-33	135.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,4GBWM@85026|Gordoniaceae	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	gca	-	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep
EH1_k127_1625405_4	644966.Tmar_1239	7.379e-18	89.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,3WCN3@538999|Clostridiales incertae sedis	186801|Clostridia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
EH1_k127_1625405_5	992406.RIA_1790	9.972e-18	87.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,1I2SS@117743|Flavobacteriia	976|Bacteroidetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
EH1_k127_1645176_0	261292.Nit79A3_1514	7.257e-19	98.0	COG0383@1|root,COG0383@2|Bacteria,1R3Q8@1224|Proteobacteria	1224|Proteobacteria	G	Alpha-Mannosidase	mngB	GO:0003674,GO:0003824,GO:0004553,GO:0004559,GO:0005975,GO:0005996,GO:0006013,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015923,GO:0016787,GO:0016798,GO:0019318,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0071704,GO:1901135,GO:1901564	3.2.1.170,3.2.1.24	ko:K01191,ko:K15524	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	iEcolC_1368.EcolC_2924,iSF_1195.SF0565,iSFxv_1172.SFxv_0623,iS_1188.S0578	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
EH1_k127_1645176_1	562970.Btus_0530	0.0003341	44.0	COG2318@1|root,COG2318@2|Bacteria,1V51W@1239|Firmicutes,4HIYI@91061|Bacilli	91061|Bacilli	S	PFAM DinB family protein	-	-	-	-	-	-	-	-	-	-	-	-	DinB
EH1_k127_1674046_0	1265503.KB905164_gene1910	1.938e-67	248.0	COG1785@1|root,COG3291@1|root,COG1785@2|Bacteria,COG3291@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,2Q71C@267889|Colwelliaceae	1236|Gammaproteobacteria	P	Alkaline phosphatase homologues	phoA	GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0004721,GO:0005488,GO:0005575,GO:0005623,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016491,GO:0016695,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0030288,GO:0030313,GO:0030613,GO:0031975,GO:0033748,GO:0036211,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0140096,GO:1901564	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	iECO111_1330.ECO111_0413,iECO26_1355.ECO26_0416	Alk_phosphatase
EH1_k127_1674046_2	701521.PECL_1654	8.725e-05	54.0	COG1266@1|root,COG1266@2|Bacteria,1VMEK@1239|Firmicutes,4IG6B@91061|Bacilli,3F7QT@33958|Lactobacillaceae	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH1_k127_1674046_1	1112204.GPOL_c15200	1.96e-15	85.0	2ERKW@1|root,33J6D@2|Bacteria,2I7F1@201174|Actinobacteria,4GGVG@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1699677_2	580331.Thit_0765	4.331e-13	82.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,42FS7@68295|Thermoanaerobacterales	186801|Clostridia	M	Serine protease with a broad substrate specificity	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
EH1_k127_1699677_3	401526.TcarDRAFT_2486	3.55e-10	72.0	COG0477@1|root,COG2814@2|Bacteria,1TQM0@1239|Firmicutes,4H2AW@909932|Negativicutes	909932|Negativicutes	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,Sugar_tr
EH1_k127_1699677_0	760568.Desku_1471	6.255e-56	206.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,26325@186807|Peptococcaceae	186801|Clostridia	E	histidinol phosphate phosphatase	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
EH1_k127_1699677_1	864702.OsccyDRAFT_4130	3.926e-22	104.0	COG0457@1|root,COG0457@2|Bacteria,1G1U5@1117|Cyanobacteria,1H859@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
EH1_k127_1701391_3	1125863.JAFN01000001_gene1334	2.236e-64	231.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42Q6C@68525|delta/epsilon subdivisions,2WMD6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
EH1_k127_1701391_2	439235.Dalk_2102	1.545e-64	229.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
EH1_k127_1701391_6	1444309.JAQG01000157_gene3286	3.513e-14	81.0	COG1011@1|root,COG1011@2|Bacteria,1V3WC@1239|Firmicutes,4IPNC@91061|Bacilli,2760Q@186822|Paenibacillaceae	91061|Bacilli	S	HAD-hyrolase-like	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
EH1_k127_1701391_8	56110.Oscil6304_2628	5.964e-05	49.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Pkinase,TM2,TPR_8,VIT,VWA_3,WD40
EH1_k127_1701391_7	269797.Mbar_A2531	5.429e-09	67.0	COG2512@1|root,arCOG00377@2157|Archaea,2XY2E@28890|Euryarchaeota	28890|Euryarchaeota	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
EH1_k127_1701391_4	370438.PTH_1362	7.936e-59	206.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,261QG@186807|Peptococcaceae	186801|Clostridia	I	methylmalonyl-CoA mutase C-terminal	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
EH1_k127_1701391_1	702437.HMPREF9432_00410	1.033e-98	336.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,4H1WI@909932|Negativicutes	909932|Negativicutes	E	LAO AO transport system	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
EH1_k127_1701391_0	273068.TTE1217	2.888e-253	791.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
EH1_k127_1701391_5	1232410.KI421417_gene2738	8.381e-28	113.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,43V0S@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
EH1_k127_1705573_2	604354.TSIB_1927	1.793e-17	89.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
EH1_k127_1705573_3	374847.Kcr_0387	1.055e-14	81.0	arCOG03119@1|root,arCOG03119@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
EH1_k127_1705573_0	263358.VAB18032_04350	6.708e-95	323.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4DAG6@85008|Micromonosporales	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
EH1_k127_1705573_1	1054217.TALC_01537	2.458e-37	144.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,242ID@183967|Thermoplasmata	28890|Euryarchaeota	C	4Fe-4S dicluster domain	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
EH1_k127_1724073_1	634497.HAH_1769	3.646e-35	139.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,23S1T@183963|Halobacteria	183963|Halobacteria	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	ogg	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
EH1_k127_1724073_2	368408.Tpen_0623	3.034e-33	143.0	COG2219@1|root,arCOG03013@2157|Archaea,2XQ8M@28889|Crenarchaeota	28889|Crenarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
EH1_k127_1724073_3	31964.CMS1858	1.024e-05	57.0	COG0500@1|root,COG2226@2|Bacteria,2GK8Y@201174|Actinobacteria,4FS8U@85023|Microbacteriaceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
EH1_k127_1724073_0	1365176.N186_07100	1.311e-67	238.0	COG1415@1|root,arCOG04253@2157|Archaea,2XPKU@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
EH1_k127_1724633_15	740709.A10D4_12268	1.492e-22	111.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,1RP0R@1236|Gammaproteobacteria,2QFVM@267893|Idiomarinaceae	1236|Gammaproteobacteria	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
EH1_k127_1724633_29	589924.Ferp_0909	3.48e-06	53.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2Y8J1@28890|Euryarchaeota,247IF@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
EH1_k127_1724633_17	224325.AF_0598	7.837e-17	87.0	COG2405@1|root,arCOG00717@2157|Archaea,2XXNX@28890|Euryarchaeota,247CV@183980|Archaeoglobi	183980|Archaeoglobi	V	Domain of unknown function (DUF3368)	-	-	-	ko:K07066	-	-	-	-	ko00000	-	-	-	DUF3368
EH1_k127_1724633_27	694429.Pyrfu_1968	1.381e-07	63.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
EH1_k127_1724633_9	1345697.M493_03760	9.467e-49	180.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,4HH5X@91061|Bacilli,1WFQD@129337|Geobacillus	91061|Bacilli	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
EH1_k127_1724633_12	1220534.B655_2000	1.881e-23	104.0	COG5646@1|root,arCOG09457@2157|Archaea,2Y1ED@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
EH1_k127_1724633_3	868131.MSWAN_0191	6.746e-109	359.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,23PWY@183925|Methanobacteria	183925|Methanobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
EH1_k127_1724633_1	1231241.Mc24_05745	4.521e-183	590.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GC9M@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	POR,POR_N
EH1_k127_1724633_0	1305737.JAFX01000001_gene448	1.021e-210	667.0	COG0827@1|root,COG0827@2|Bacteria,4PMZI@976|Bacteroidetes	976|Bacteroidetes	L	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,N6_Mtase
EH1_k127_1724633_30	565033.GACE_1711	5.332e-05	54.0	28H6E@1|root,2N56E@2157|Archaea,2Y3KB@28890|Euryarchaeota,24736@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1724633_24	324602.Caur_0091	3.579e-08	65.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,2G8R0@200795|Chloroflexi	200795|Chloroflexi	CT	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NACHT
EH1_k127_1724633_4	1121342.AUCO01000004_gene607	4.779e-107	359.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH1_k127_1724633_6	5334.XP_003028257.1	1.067e-63	228.0	COG1028@1|root,KOG1200@2759|Eukaryota,39KUT@33154|Opisthokonta,3Q584@4751|Fungi,3V7AR@5204|Basidiomycota	4751|Fungi	Q	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
EH1_k127_1724633_14	635013.TherJR_2506	9.752e-23	108.0	COG0500@1|root,COG2226@2|Bacteria,1V6QV@1239|Firmicutes,24JPQ@186801|Clostridia,267C0@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
EH1_k127_1724633_13	929506.CbC4_2451	2.811e-23	109.0	COG1082@1|root,COG1082@2|Bacteria,1V56C@1239|Firmicutes,24D55@186801|Clostridia,36I65@31979|Clostridiaceae	186801|Clostridia	L	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH1_k127_1724633_31	290633.GOX1783	5.601e-05	54.0	COG0494@1|root,COG0494@2|Bacteria,1NB1Q@1224|Proteobacteria,2UHU4@28211|Alphaproteobacteria,2JYC1@204441|Rhodospirillales	204441|Rhodospirillales	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1724633_16	1348657.M622_01255	2.683e-19	98.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria,2KZSR@206389|Rhodocyclales	206389|Rhodocyclales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_1724633_26	456442.Mboo_0952	7.239e-08	62.0	arCOG04915@1|root,arCOG04915@2157|Archaea,2Y3CG@28890|Euryarchaeota,2NAQQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1724633_28	1297742.A176_01071	1.738e-06	58.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
EH1_k127_1724633_25	1033806.HTIA_1328	5.286e-08	63.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
EH1_k127_1724633_8	634497.HAH_2740	4.776e-54	211.0	COG1073@1|root,arCOG01649@2157|Archaea,2XW9X@28890|Euryarchaeota,23T03@183963|Halobacteria	183963|Halobacteria	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
EH1_k127_1724633_2	1365176.N186_05795	3.89e-172	551.0	COG1350@1|root,arCOG01432@2157|Archaea,2XQ0U@28889|Crenarchaeota	28889|Crenarchaeota	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH1_k127_1724633_10	515635.Dtur_0011	7.358e-42	157.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
EH1_k127_1724633_11	679926.Mpet_0440	2.661e-31	132.0	arCOG02703@1|root,arCOG02703@2157|Archaea,2XY9N@28890|Euryarchaeota	28890|Euryarchaeota	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH1_k127_1724633_21	706587.Desti_3492	2.649e-12	74.0	COG0479@1|root,COG0479@2|Bacteria,1R112@1224|Proteobacteria,43D4Y@68525|delta/epsilon subdivisions,2WR5U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
EH1_k127_1724633_7	565033.GACE_0310	9.17e-62	229.0	arCOG00516@1|root,arCOG04739@1|root,arCOG00516@2157|Archaea,arCOG04739@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
EH1_k127_1724633_19	565033.GACE_0311	3.048e-13	77.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2Y3UM@28890|Euryarchaeota,2475H@183980|Archaeoglobi	183980|Archaeoglobi	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
EH1_k127_1724633_18	933262.AXAM01000010_gene1397	4.068e-15	77.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,42S33@68525|delta/epsilon subdivisions,2WNKG@28221|Deltaproteobacteria,2MJWX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1724633_32	1121875.KB907560_gene526	0.0001591	47.0	2DNPH@1|root,32YF1@2|Bacteria,4NVUP@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1724633_5	755731.Clo1100_1035	2.525e-78	268.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,36DSU@31979|Clostridiaceae	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
EH1_k127_1737537_0	1122939.ATUD01000020_gene2153	2.676e-42	168.0	COG2222@1|root,COG2222@2|Bacteria,2IN5A@201174|Actinobacteria,4CP71@84995|Rubrobacteria	84995|Rubrobacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
EH1_k127_1737537_1	1122614.JHZF01000011_gene1317	2.538e-23	110.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,2PC6Z@252301|Oceanicola	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
EH1_k127_1737537_2	351160.RCIX511	3.533e-08	63.0	COG0637@1|root,arCOG02293@2157|Archaea,2XTYU@28890|Euryarchaeota,2NAS6@224756|Methanomicrobia	224756|Methanomicrobia	S	Haloacid dehalogenase-like hydrolase	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
EH1_k127_1783451_4	272844.PAB0892	2.771e-47	175.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,243TQ@183968|Thermococci	183968|Thermococci	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD1	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
EH1_k127_1783451_0	573064.Mefer_0713	1.933e-124	411.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23QNF@183939|Methanococci	183939|Methanococci	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
EH1_k127_1783451_1	1121946.AUAX01000021_gene8088	6.019e-99	335.0	COG0473@1|root,COG0473@2|Bacteria,2I8V7@201174|Actinobacteria	201174|Actinobacteria	CE	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
EH1_k127_1783451_2	1345697.M493_07445	2.192e-78	272.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,4HCBR@91061|Bacilli,1WG3J@129337|Geobacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.5	ko:K16164	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
EH1_k127_1783451_3	502025.Hoch_1987	4.151e-60	224.0	COG3345@1|root,COG3345@2|Bacteria,1MWTQ@1224|Proteobacteria	1224|Proteobacteria	G	alpha-galactosidase	galA	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
EH1_k127_1799004_2	1121087.AUCK01000015_gene1593	1.723e-67	243.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9S5@91061|Bacilli,1ZCDJ@1386|Bacillus	91061|Bacilli	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
EH1_k127_1799004_0	1041930.Mtc_1790	5.039e-134	437.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
EH1_k127_1799004_1	883.DvMF_2989	4.232e-83	299.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2M8S9@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
EH1_k127_1799004_3	368408.Tpen_1033	3.318e-06	52.0	arCOG03776@1|root,arCOG03776@2157|Archaea,2XSKE@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Zinc finger TFIIB-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
EH1_k127_1803553_1	648996.Theam_1336	5.569e-34	134.0	2E4R1@1|root,32ZJK@2|Bacteria,2G53K@200783|Aquificae	200783|Aquificae	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
EH1_k127_1803553_0	387631.Asulf_00767	2.309e-42	180.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,245Y7@183980|Archaeoglobi	183980|Archaeoglobi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
EH1_k127_1803553_2	102125.Xen7305DRAFT_00004660	2.097e-08	66.0	COG0465@1|root,COG0465@2|Bacteria,1G22Z@1117|Cyanobacteria,3VICX@52604|Pleurocapsales	1117|Cyanobacteria	O	FtsH Extracellular	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
EH1_k127_1803553_3	866771.HMPREF9296_0495	4.761e-07	55.0	COG0714@1|root,COG0714@2|Bacteria,4PAE8@976|Bacteroidetes,2FWQG@200643|Bacteroidia	976|Bacteroidetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
EH1_k127_1810244_3	192952.MM_0980	4.737e-10	64.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,2N93S@224756|Methanomicrobia	224756|Methanomicrobia	C	CoB--CoM heterodisulfide reductase subunit B	hdrB-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
EH1_k127_1810244_1	1499967.BAYZ01000171_gene5564	8.887e-23	104.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
EH1_k127_1810244_0	1121472.AQWN01000006_gene1831	6.163e-262	835.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2
EH1_k127_1810244_2	246194.CHY_1865	7.493e-15	85.0	COG1378@1|root,COG1378@2|Bacteria,1UV3K@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
EH1_k127_1814664_6	926692.AZYG01000081_gene606	0.0003688	44.0	2C7S2@1|root,2ZE3S@2|Bacteria	2|Bacteria	S	Protein of unknown function with HXXEE motif	-	-	-	-	-	-	-	-	-	-	-	-	HXXEE
EH1_k127_1814664_5	485913.Krac_1137	1.136e-06	53.0	2C7S2@1|root,2ZE3S@2|Bacteria	2|Bacteria	S	Protein of unknown function with HXXEE motif	-	-	-	-	-	-	-	-	-	-	-	-	HXXEE
EH1_k127_1814664_7	177437.HRM2_40030	0.0006922	52.0	COG0477@1|root,COG0477@2|Bacteria,1QWNY@1224|Proteobacteria,43BTW@68525|delta/epsilon subdivisions,2X74T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_1814664_3	1242864.D187_005320	6.877e-41	162.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2Z1ZD@29|Myxococcales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
EH1_k127_1814664_4	1410668.JNKC01000006_gene678	1.526e-29	130.0	COG0671@1|root,COG0671@2|Bacteria,1V01Y@1239|Firmicutes,24DFI@186801|Clostridia,36VSV@31979|Clostridiaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
EH1_k127_1814664_1	945713.IALB_2155	1.248e-100	349.0	COG2195@1|root,COG2195@2|Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	iPC815.YPO3230,iSBO_1134.SBO_0243	M20_dimer,Peptidase_M20
EH1_k127_1814664_0	224325.AF_0340	6.208e-142	472.0	COG2414@1|root,arCOG00706@2157|Archaea,2XWCH@28890|Euryarchaeota,245R8@183980|Archaeoglobi	183980|Archaeoglobi	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_1814664_2	926550.CLDAP_35830	2.174e-99	336.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
EH1_k127_1831800_1	574087.Acear_0203	6.981e-17	94.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TQJM@1239|Firmicutes,24CFC@186801|Clostridia	186801|Clostridia	C	TIGRFAM glycerol-3-phosphate dehydrogenase, anaerobic, C subunit	glpC	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
EH1_k127_1831800_0	429009.Adeg_1006	1.508e-178	580.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42FB7@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_1831800_2	1121438.JNJA01000004_gene781	0.0001958	47.0	COG1977@1|root,COG1977@2|Bacteria,1NH6M@1224|Proteobacteria,42X05@68525|delta/epsilon subdivisions,2WSK5@28221|Deltaproteobacteria,2MD55@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM ThiamineS	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
EH1_k127_1863390_0	368408.Tpen_0478	4.475e-41	173.0	COG1199@1|root,arCOG00770@2157|Archaea,2XPRS@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM DEAD_2 domain protein	-	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0043139,GO:0048037,GO:0051276,GO:0051536,GO:0051539,GO:0051540,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
EH1_k127_1891944_1	1121472.AQWN01000006_gene1750	2.379e-54	204.0	COG0857@1|root,COG0857@2|Bacteria,1UFKM@1239|Firmicutes,25M79@186801|Clostridia,260XJ@186807|Peptococcaceae	186801|Clostridia	C	DRTGG domain protein	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
EH1_k127_1891944_2	1232410.KI421415_gene2936	2.398e-10	70.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH1_k127_1891944_0	349161.Dred_1493	4.717e-63	223.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,2648P@186807|Peptococcaceae	186801|Clostridia	C	PFAM 3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
EH1_k127_1896917_7	436308.Nmar_1326	7.005e-10	68.0	COG3398@1|root,arCOG02611@2157|Archaea	436308.Nmar_1326|-	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1896917_1	579137.Metvu_1137	4.776e-54	199.0	COG1136@1|root,arCOG00922@2157|Archaea,2XV0G@28890|Euryarchaeota,23QFT@183939|Methanococci	183939|Methanococci	E	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_1896917_0	243232.MJ_0539	1.443e-91	322.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,23Q0A@183939|Methanococci	183939|Methanococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
EH1_k127_1896917_2	324602.Caur_1425	2.039e-32	136.0	COG0558@1|root,COG0558@2|Bacteria,2GAQW@200795|Chloroflexi,3773G@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
EH1_k127_1896917_6	226186.BT_3576	4.085e-10	68.0	COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,2FM38@200643|Bacteroidia,4AKYF@815|Bacteroidaceae	976|Bacteroidetes	G	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
EH1_k127_1896917_3	195522.BD01_2200	4.623e-25	108.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y6ET@28890|Euryarchaeota,244B9@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
EH1_k127_1896917_5	1094980.Mpsy_2777	1.319e-14	81.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
EH1_k127_1896917_4	1459636.NTE_01923	7.227e-19	89.0	COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
EH1_k127_1911064_0	1341151.ASZU01000008_gene1425	1.079e-75	262.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,27BD2@186824|Thermoactinomycetaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
EH1_k127_1911064_1	1499967.BAYZ01000028_gene1366	4.062e-51	190.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
EH1_k127_1912437_1	1094980.Mpsy_3151	9.537e-23	105.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_1912437_0	1463917.JODC01000007_gene7319	1.011e-96	329.0	COG0457@1|root,COG0457@2|Bacteria,2I7P1@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037,TPR_12
EH1_k127_1927627_1	1051632.TPY_1129	1.145e-19	95.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WCCQ@538999|Clostridiales incertae sedis	186801|Clostridia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH1_k127_1927627_0	8153.XP_005926811.1	5.657e-25	115.0	KOG0093@1|root,KOG0093@2759|Eukaryota,38F35@33154|Opisthokonta,3BAAA@33208|Metazoa,3CREC@33213|Bilateria,48ANG@7711|Chordata,48VEX@7742|Vertebrata,4A0B5@7898|Actinopterygii	33208|Metazoa	U	RAB3D, member RAS oncogene family	RAB3D	GO:0000323,GO:0001775,GO:0001894,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005765,GO:0005766,GO:0005773,GO:0005774,GO:0005856,GO:0005874,GO:0005881,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008092,GO:0008150,GO:0008152,GO:0008213,GO:0009987,GO:0012505,GO:0012506,GO:0015630,GO:0016020,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017111,GO:0017157,GO:0018125,GO:0018193,GO:0018198,GO:0019538,GO:0030133,GO:0030141,GO:0030659,GO:0030667,GO:0030742,GO:0031090,GO:0031410,GO:0031489,GO:0031982,GO:0032259,GO:0032501,GO:0032879,GO:0032940,GO:0035577,GO:0036211,GO:0036230,GO:0042119,GO:0042582,GO:0042588,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043299,GO:0043312,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044430,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0045453,GO:0045921,GO:0046849,GO:0046903,GO:0048518,GO:0048522,GO:0048771,GO:0048871,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0060249,GO:0060627,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0097708,GO:0098588,GO:0098805,GO:0098852,GO:0099080,GO:0099081,GO:0099503,GO:0099512,GO:0099513,GO:1901564,GO:1903305,GO:1903307,GO:1903530,GO:1903532	-	ko:K07884	ko04972,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_1927627_2	1122176.KB903536_gene1796	6.417e-17	81.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1IWK9@117747|Sphingobacteriia	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
EH1_k127_1935710_0	926550.CLDAP_39580	6.948e-41	161.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
EH1_k127_1938566_1	771875.Ferpe_1310	4.849e-54	193.0	COG0778@1|root,COG0778@2|Bacteria,2GCST@200918|Thermotogae	200918|Thermotogae	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH1_k127_1938566_2	530564.Psta_4322	2.412e-47	173.0	COG2335@1|root,COG2335@2|Bacteria,2IZDI@203682|Planctomycetes	203682|Planctomycetes	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
EH1_k127_1938566_4	1365176.N186_01885	6.583e-26	115.0	COG1599@1|root,arCOG01510@2157|Archaea	2157|Archaea	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	3.6.4.12	ko:K03658,ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko01000,ko03000,ko03032,ko03400	-	-	-	PLDc_2,UvrD-helicase,UvrD_C,tRNA_anti-codon
EH1_k127_1938566_6	43151.ADAC001036-PA	1.893e-07	62.0	COG4886@1|root,KOG0619@2759|Eukaryota,38EBU@33154|Opisthokonta,3BM0W@33208|Metazoa,3D574@33213|Bilateria,41YC3@6656|Arthropoda,3SGB2@50557|Insecta,44Z1G@7147|Diptera,45BWZ@7148|Nematocera	33208|Metazoa	T	Leucine-rich repeats, typical (most populated) subfamily	-	-	-	-	-	-	-	-	-	-	-	-	LRR_8,fn3
EH1_k127_1938566_5	1280692.AUJL01000017_gene1032	2.632e-20	98.0	COG0655@1|root,COG0655@2|Bacteria,1V26K@1239|Firmicutes,24IAS@186801|Clostridia,36VWE@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
EH1_k127_1938566_0	1220534.B655_2250	6.42e-63	224.0	COG1321@1|root,arCOG02099@2157|Archaea,2XSWC@28890|Euryarchaeota,23P0S@183925|Methanobacteria	183925|Methanobacteria	K	Iron dependent	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
EH1_k127_1938566_3	765420.OSCT_1176	1.086e-41	158.0	COG0370@1|root,COG0370@2|Bacteria,2G8KC@200795|Chloroflexi,376RH@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM small GTP-binding protein	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_N
EH1_k127_194217_2	525904.Tter_0696	1.492e-12	81.0	COG0419@1|root,COG1122@1|root,COG0419@2|Bacteria,COG1122@2|Bacteria	2|Bacteria	P	ATPase activity	sbcC	-	-	ko:K03546,ko:K16786,ko:K16787,ko:K19171	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03400	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	AAA_23,ABC_tran,Rad50_zn_hook,SMC_N,SbcCD_C
EH1_k127_194217_1	368407.Memar_1616	1.064e-17	96.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,2NA2J@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
EH1_k127_194217_0	1095769.CAHF01000005_gene1567	2.219e-109	375.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	ko:K06915,ko:K19172	-	-	-	-	ko00000,ko02048	-	-	-	DUF853,DUF87,PLDc_2
EH1_k127_194217_3	868864.Dester_1177	2.183e-07	61.0	COG2220@1|root,COG2220@2|Bacteria,2G4RA@200783|Aquificae	200783|Aquificae	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
EH1_k127_1969226_2	1235802.C823_00461	5.565e-57	203.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,25V62@186806|Eubacteriaceae	186801|Clostridia	M	DegT/DnrJ/EryC1/StrS aminotransferase family	pseC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
EH1_k127_1969226_1	1430440.MGMSRv2_3411	6.048e-58	210.0	COG0517@1|root,COG1208@1|root,COG0517@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria,2JR3Y@204441|Rhodospirillales	204441|Rhodospirillales	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,NTP_transferase
EH1_k127_1969226_0	595460.RRSWK_05623	2.451e-104	348.0	COG0451@1|root,COG0451@2|Bacteria,2IX9F@203682|Planctomycetes	203682|Planctomycetes	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
EH1_k127_1969226_3	518766.Rmar_1322	1.431e-43	174.0	COG0438@1|root,COG0438@2|Bacteria,4NE6S@976|Bacteroidetes,1FIXH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
EH1_k127_1969226_5	697281.Mahau_0354	6.687e-27	116.0	COG1044@1|root,COG1044@2|Bacteria,1UHYP@1239|Firmicutes,25E78@186801|Clostridia,42J5I@68295|Thermoanaerobacterales	186801|Clostridia	M	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
EH1_k127_1969226_8	1128398.Curi_c27500	2.96e-12	77.0	COG2159@1|root,COG2159@2|Bacteria,1UYW0@1239|Firmicutes,25CIC@186801|Clostridia,26B05@186813|unclassified Clostridiales	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
EH1_k127_1969226_7	880073.Calab_1848	1.413e-13	81.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_2,Glycos_transf_2
EH1_k127_1969226_4	1499967.BAYZ01000154_gene1533	1.804e-31	131.0	COG0084@1|root,COG0084@2|Bacteria,2NP9H@2323|unclassified Bacteria	2|Bacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
EH1_k127_1985891_0	1457250.BBMO01000001_gene657	5.599e-78	272.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,23RZH@183963|Halobacteria	183963|Halobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
EH1_k127_1988434_2	579137.Metvu_0471	1.346e-21	101.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23QW3@183939|Methanococci	183939|Methanococci	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
EH1_k127_1988434_1	760568.Desku_2708	1.348e-58	220.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
EH1_k127_1988434_3	604354.TSIB_1836	8.315e-21	98.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2441Z@183968|Thermococci	183968|Thermococci	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
EH1_k127_1988434_0	1157490.EL26_11975	1.828e-67	254.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
EH1_k127_199808_1	273116.14324400	2.174e-28	121.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,241RM@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
EH1_k127_199808_0	192952.MM_0835	2.957e-84	300.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAFK@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH1_k127_2003462_5	653386.HMPREF0975_01360	1.146e-09	66.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4D3YZ@85005|Actinomycetales	201174|Actinobacteria	S	Oxidoreductase NAD-binding domain protein	idhA	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
EH1_k127_2003462_3	436308.Nmar_1261	5.97e-29	121.0	COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	MiaB-like tRNA modifying enzyme	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
EH1_k127_2003462_2	868131.MSWAN_0679	7.711e-61	219.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,23NWM@183925|Methanobacteria	183925|Methanobacteria	J	MiaB-like tRNA modifying enzyme, archaeal-type	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
EH1_k127_2003462_6	415426.Hbut_0133	1.221e-09	63.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
EH1_k127_2003462_4	1163671.JAGI01000002_gene1644	2.004e-12	72.0	2E481@1|root,32Z3Y@2|Bacteria,1VFF1@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2003462_0	1151117.AJLF01000001_gene1051	5.418e-195	622.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
EH1_k127_2003462_1	399550.Smar_1113	1.42e-80	277.0	COG0403@1|root,arCOG00077@2157|Archaea,2XQ1W@28889|Crenarchaeota	28889|Crenarchaeota	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
EH1_k127_2035628_3	706587.Desti_5346	8.982e-42	164.0	COG0715@1|root,COG0715@2|Bacteria,1RHDX@1224|Proteobacteria,42V6G@68525|delta/epsilon subdivisions,2WRZJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	iAF987.Gmet_0996	NMT1_2
EH1_k127_2035628_1	351160.RCIX445	6.452e-50	188.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,2N99H@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
EH1_k127_2035628_0	593750.Metfor_2404	1.692e-63	228.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
EH1_k127_2035628_4	5855.PVX_124195	1.797e-30	140.0	COG1100@1|root,KOG0098@2759|Eukaryota,3Y9NR@5794|Apicomplexa,3KBPG@422676|Aconoidasida,3YWU3@5819|Haemosporida	422676|Aconoidasida	U	Rab2, GTPase	-	GO:0000139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0008150,GO:0012505,GO:0016020,GO:0017157,GO:0031090,GO:0031984,GO:0032879,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045921,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0060627,GO:0065007,GO:0098588,GO:0098791,GO:1903530,GO:1903532	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_2035628_5	706587.Desti_1356	9.507e-30	126.0	COG1014@1|root,COG1014@2|Bacteria,1RJBM@1224|Proteobacteria,42T3A@68525|delta/epsilon subdivisions,2WPV1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Indolepyruvate ferredoxin oxidoreductase, beta subunit	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
EH1_k127_2035628_2	706587.Desti_1357	4.087e-47	177.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42Q2C@68525|delta/epsilon subdivisions,2WKNN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
EH1_k127_2043903_4	1121918.ARWE01000001_gene1515	9.725e-20	94.0	COG0317@1|root,COG0317@2|Bacteria,1R9RQ@1224|Proteobacteria,42PGJ@68525|delta/epsilon subdivisions,2WMGD@28221|Deltaproteobacteria,43S84@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	HD_4,RelA_SpoT,TGS
EH1_k127_2043903_6	1246445.ANAY01000013_gene201	1.309e-09	62.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH1_k127_2043903_3	926550.CLDAP_35280	3.846e-43	168.0	COG0454@1|root,COG0456@2|Bacteria,2G91C@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_2043903_1	399550.Smar_1154	4.369e-71	251.0	COG1085@1|root,arCOG00422@2157|Archaea,2XPRT@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM galactose-1-phosphate uridyl transferase domain protein	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
EH1_k127_2043903_2	649639.Bcell_1043	3.118e-64	234.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,4HARP@91061|Bacilli,1ZC9P@1386|Bacillus	91061|Bacilli	G	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	GO:0005975,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0019318,GO:0044238,GO:0044281,GO:0071704	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
EH1_k127_2043903_0	1125863.JAFN01000001_gene2485	1.775e-175	565.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
EH1_k127_2043903_7	472759.Nhal_2547	3.139e-08	67.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria,1WWTU@135613|Chromatiales	135613|Chromatiales	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
EH1_k127_2043903_5	883156.HMPREF9282_00318	7.598e-11	74.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,4H1VG@909932|Negativicutes	909932|Negativicutes	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
EH1_k127_2057445_3	387631.Asulf_00521	3.405e-18	95.0	COG3979@1|root,COG5306@1|root,arCOG02420@1|root,arCOG03511@1|root,arCOG03553@1|root,arCOG09173@1|root,arCOG02420@2157|Archaea,arCOG03508@2157|Archaea,arCOG03511@2157|Archaea,arCOG03553@2157|Archaea,arCOG07581@2157|Archaea,arCOG09173@2157|Archaea	2157|Archaea	C	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF2341,PKD,Pilin_N,S_layer_C
EH1_k127_2057445_2	439481.Aboo_1209	3.009e-21	108.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
EH1_k127_2057445_0	469382.Hbor_19920	4.519e-36	153.0	COG0477@1|root,arCOG00130@2157|Archaea,2XSTP@28890|Euryarchaeota,23SQI@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_2061005_2	1341181.FLJC2902T_08400	0.0004564	50.0	COG0526@1|root,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1I2TH@117743|Flavobacteriia,2NW4R@237|Flavobacterium	976|Bacteroidetes	CO	Thioredoxin	txn	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
EH1_k127_2061005_0	755178.Cyan10605_0660	1.242e-07	64.0	COG0501@1|root,COG0501@2|Bacteria,1G0EW@1117|Cyanobacteria	1117|Cyanobacteria	E	Zn-dependent protease with chaperone function	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
EH1_k127_2061005_1	596152.DesU5LDRAFT_1012	1.808e-07	62.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,43BMI@68525|delta/epsilon subdivisions,2X6ZQ@28221|Deltaproteobacteria,2MH9D@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	drug resistance transporter, EmrB QacA subfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
EH1_k127_2069234_0	926569.ANT_17050	1.394e-45	172.0	COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
EH1_k127_2069234_1	94624.Bpet4822	1.028e-24	118.0	COG0438@1|root,COG0438@2|Bacteria,1R2WM@1224|Proteobacteria,2VKPJ@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
EH1_k127_2071273_0	1120936.KB907212_gene5155	1.64e-23	111.0	COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
EH1_k127_2071273_4	517417.Cpar_0640	0.0003419	53.0	COG0823@1|root,COG0823@2|Bacteria,1FEIQ@1090|Chlorobi	1090|Chlorobi	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
EH1_k127_2071273_1	5127.CCT62312	7.312e-12	73.0	2DZRN@1|root,2S78G@2759|Eukaryota,3A2J4@33154|Opisthokonta,3P5YK@4751|Fungi,3QVC2@4890|Ascomycota,219Q2@147550|Sordariomycetes,3TIRD@5125|Hypocreales,1FMSI@110618|Nectriaceae	4751|Fungi	S	GDSL-like Lipase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
EH1_k127_2071273_2	715226.ABI_46630	1.016e-10	72.0	COG0793@1|root,COG0793@2|Bacteria,1N4T9@1224|Proteobacteria	1224|Proteobacteria	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ_2
EH1_k127_2071273_3	374847.Kcr_0937	2.079e-07	59.0	COG3371@1|root,arCOG02008@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
EH1_k127_2091451_1	374847.Kcr_0159	1.34e-65	235.0	COG0665@1|root,arCOG00755@2157|Archaea	2157|Archaea	E	COG0665 Glycine D-amino acid oxidases (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH1_k127_2091451_2	1304284.L21TH_0250	4.404e-09	60.0	COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia,36F99@31979|Clostridiaceae	186801|Clostridia	P	transporter	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
EH1_k127_2091451_0	1122223.KB890701_gene2220	2.173e-98	332.0	COG0205@1|root,COG0205@2|Bacteria,1WINW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
EH1_k127_2136210_18	246969.TAM4_510	1.572e-34	144.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,242IT@183968|Thermococci	183968|Thermococci	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
EH1_k127_2136210_33	399550.Smar_0122	8.448e-06	53.0	arCOG10940@1|root,arCOG10940@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4064
EH1_k127_2136210_5	335543.Sfum_0405	3.883e-63	226.0	COG0123@1|root,COG0123@2|Bacteria,1RBR4@1224|Proteobacteria,42R2Z@68525|delta/epsilon subdivisions,2WN6H@28221|Deltaproteobacteria,2MR74@213462|Syntrophobacterales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
EH1_k127_2136210_21	1343739.PAP_02260	1.653e-27	114.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,244BE@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
EH1_k127_2136210_6	797209.ZOD2009_07774	1.486e-61	225.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23T1A@183963|Halobacteria	183963|Halobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
EH1_k127_2136210_10	1041930.Mtc_1421	1.965e-46	175.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,2N9HV@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
EH1_k127_2136210_11	272844.PAB2353	2.546e-46	173.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,243FN@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
EH1_k127_2136210_19	387631.Asulf_01296	1.149e-27	121.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,24688@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
EH1_k127_2136210_3	1220534.B655_0248	6.223e-104	349.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,23NJT@183925|Methanobacteria	183925|Methanobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
EH1_k127_2136210_16	797209.ZOD2009_21917	8.046e-38	154.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23SW4@183963|Halobacteria	183963|Halobacteria	G	Belongs to the carbohydrate kinase PfkB family	suk	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
EH1_k127_2136210_1	477974.Daud_0343	1.073e-112	371.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,2608G@186807|Peptococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
EH1_k127_2136210_4	523850.TON_0592	4.268e-93	315.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
EH1_k127_2136210_32	1041930.Mtc_0441	3.718e-07	58.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
EH1_k127_2136210_30	572478.Vdis_0025	5.359e-08	57.0	COG2157@1|root,arCOG04175@2157|Archaea	2157|Archaea	J	PFAM Ribosomal LX protein	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
EH1_k127_2136210_8	186497.PF0377	3.029e-49	183.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,243II@183968|Thermococci	183968|Thermococci	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
EH1_k127_2136210_25	579137.Metvu_1093	1.66e-14	78.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23R3K@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein L31e	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
EH1_k127_2136210_28	384616.Pisl_0442	3.237e-11	66.0	COG2167@1|root,arCOG04177@2157|Archaea,2XRC0@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
EH1_k127_2136210_22	192952.MM_0803	5.083e-24	105.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
EH1_k127_2136210_9	604354.TSIB_0524	6.816e-49	179.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,242ZB@183968|Thermococci	183968|Thermococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
EH1_k127_2136210_34	1041930.Mtc_2172	1.511e-05	54.0	COG1534@1|root,arCOG01346@2157|Archaea,2XZWJ@28890|Euryarchaeota	28890|Euryarchaeota	J	RNA-binding protein containing KH domain, possibly ribosomal protein	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
EH1_k127_2136210_27	304371.MCP_0304	2.631e-13	74.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
EH1_k127_2136210_14	399550.Smar_1081	4.433e-42	164.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
EH1_k127_2136210_2	1229909.NSED_07320	2.442e-104	364.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
EH1_k127_2136210_15	525904.Tter_2667	7.351e-39	151.0	COG0394@1|root,COG0394@2|Bacteria,2NPGV@2323|unclassified Bacteria	2|Bacteria	T	Low molecular weight phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
EH1_k127_2136210_7	706587.Desti_3979	3.405e-53	196.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15560	OMPdecase,Pribosyltran
EH1_k127_2136210_29	489825.LYNGBM3L_33260	3.126e-09	70.0	COG1131@1|root,COG1131@2|Bacteria,1GQKB@1117|Cyanobacteria	1117|Cyanobacteria	V	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16
EH1_k127_2136210_13	1123405.AUMM01000005_gene847	3.076e-42	159.0	COG0756@1|root,COG0756@2|Bacteria	2|Bacteria	F	dUTP diphosphatase activity	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	iIT341.HP0865	dUTPase
EH1_k127_2136210_24	304371.MCP_1700	8.936e-18	87.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y44E@28890|Euryarchaeota,2NBAZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
EH1_k127_2136210_12	572478.Vdis_1875	2.83e-44	166.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQPI@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
EH1_k127_2136210_31	1157640.AQWO01000017_gene3483	3.069e-07	60.0	COG0500@1|root,COG2226@2|Bacteria,2IB7N@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
EH1_k127_2136210_23	386456.JQKN01000002_gene2403	4.943e-19	88.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
EH1_k127_2136210_26	1459636.NTE_02161	5.173e-14	75.0	COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
EH1_k127_2136210_20	523845.AQXV01000040_gene1688	1.558e-27	121.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,23QZV@183939|Methanococci	183939|Methanococci	J	PFAM PUA domain containing protein	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
EH1_k127_2136210_17	368408.Tpen_0498	1.637e-35	157.0	COG1204@1|root,arCOG00553@2157|Archaea,2XPUH@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
EH1_k127_2136210_0	868131.MSWAN_2098	1.594e-222	706.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
EH1_k127_2160413_1	86416.Clopa_1099	1.307e-20	99.0	COG0500@1|root,COG2226@2|Bacteria,1UI7M@1239|Firmicutes,24E0D@186801|Clostridia,36N6N@31979|Clostridiaceae	186801|Clostridia	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
EH1_k127_2160413_2	195522.BD01_1115	1.034e-19	100.0	COG0454@1|root,arCOG00845@2157|Archaea,2Y67B@28890|Euryarchaeota,2430F@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_2160413_0	591019.Shell_0611	1.666e-65	234.0	COG1136@1|root,arCOG00922@2157|Archaea,2XQG8@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_2160413_3	1033730.CAHG01000006_gene1180	3.302e-06	59.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4DP5J@85009|Propionibacteriales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH1_k127_2178838_26	768679.TTX_1933	1.719e-15	81.0	COG1958@1|root,arCOG00999@2157|Archaea,2XR1U@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
EH1_k127_2178838_2	573064.Mefer_0206	3.719e-120	398.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
EH1_k127_2178838_30	69014.TK2270	5.825e-11	64.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZXP@28890|Euryarchaeota,244NJ@183968|Thermococci	183968|Thermococci	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
EH1_k127_2178838_11	309800.C498_08095	7.486e-74	255.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,23RZZ@183963|Halobacteria	183963|Halobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2p	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
EH1_k127_2178838_24	1183377.Py04_1705	5.336e-23	100.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
EH1_k127_2178838_10	386456.JQKN01000001_gene1762	6.744e-74	256.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
EH1_k127_2178838_5	572546.Arcpr_1361	2.95e-103	346.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
EH1_k127_2178838_22	339860.Msp_0910	7.423e-37	150.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota,23NTH@183925|Methanobacteria	183925|Methanobacteria	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
EH1_k127_2178838_25	671065.MetMK1DRAFT_00021540	3.162e-21	98.0	COG1371@1|root,arCOG04055@2157|Archaea,2XQYK@28889|Crenarchaeota	28889|Crenarchaeota	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
EH1_k127_2178838_0	573063.Metin_0452	1.306e-157	514.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,23Q36@183939|Methanococci	183939|Methanococci	K	SMART Elongator protein 3 MiaB NifB	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Acetyltransf_10,Radical_SAM,Radical_SAM_C
EH1_k127_2178838_33	273057.SSO6817	1.864e-08	59.0	COG4919@1|root,arCOG04293@2157|Archaea,2XR5C@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
EH1_k127_2178838_17	243232.MJ_1446	6.091e-61	220.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,23QKQ@183939|Methanococci	183939|Methanococci	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
EH1_k127_2178838_9	269797.Mbar_A1466	3.168e-80	279.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
EH1_k127_2178838_7	591019.Shell_1197	5.542e-89	309.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
EH1_k127_2178838_14	1042877.GQS_08995	3.522e-68	238.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,24333@183968|Thermococci	183968|Thermococci	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
EH1_k127_2178838_31	1183377.Py04_0621	9.6e-10	67.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota,244BU@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
EH1_k127_2178838_20	70601.3258244	7.884e-47	181.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,242IM@183968|Thermococci	183968|Thermococci	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
EH1_k127_2178838_19	1041930.Mtc_0490	3.507e-50	187.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,2N9PE@224756|Methanomicrobia	224756|Methanomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
EH1_k127_2178838_6	374847.Kcr_1153	3.698e-89	307.0	COG4046@1|root,arCOG04181@2157|Archaea	2157|Archaea	S	DUF1512 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
EH1_k127_2178838_15	399549.Msed_2126	9.837e-68	241.0	COG0024@1|root,arCOG01001@2157|Archaea,2XPVJ@28889|Crenarchaeota	28889|Crenarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
EH1_k127_2178838_4	391623.TERMP_00204	9.768e-108	364.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
EH1_k127_2178838_3	439481.Aboo_1394	9.497e-108	365.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,3F2HJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	AAA domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
EH1_k127_2178838_13	593117.TGAM_1098	3.497e-70	251.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
EH1_k127_2178838_8	1236689.MMALV_16390	3.699e-81	283.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
EH1_k127_2178838_16	399550.Smar_0886	2.98e-62	221.0	COG2413@1|root,arCOG04066@2157|Archaea,2XQ4I@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
EH1_k127_2178838_12	342949.PNA2_0268	5.217e-73	257.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
EH1_k127_2178838_21	272844.PAB2195	2.263e-46	186.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
EH1_k127_2178838_23	573064.Mefer_0036	1.255e-32	131.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23R2F@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
EH1_k127_2178838_1	402880.MmarC5_0382	3.04e-152	491.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
EH1_k127_2178838_29	523850.TON_1943	1.251e-11	72.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
EH1_k127_2178838_18	195522.BD01_1505	1.147e-55	200.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,243RT@183968|Thermococci	183968|Thermococci	K	DNA-directed RNA polymerase, subunit E	rpoE1	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
EH1_k127_2178838_32	593117.TGAM_0500	2.643e-09	63.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,244KC@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
EH1_k127_2178838_27	604354.TSIB_0029	1.651e-14	79.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,244BP@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
EH1_k127_2178838_28	410358.Mlab_0654	1.018e-12	71.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
EH1_k127_2181827_1	386456.JQKN01000010_gene695	5.641e-130	436.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23NUK@183925|Methanobacteria	183925|Methanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
EH1_k127_2181827_3	767817.Desgi_1164	1.766e-49	180.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,261SC@186807|Peptococcaceae	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
EH1_k127_2181827_2	573064.Mefer_0239	1.112e-60	221.0	COG1941@1|root,arCOG02472@2157|Archaea,2XVJ0@28890|Euryarchaeota,23QEJ@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	vhuG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
EH1_k127_2181827_0	579137.Metvu_1488	1.621e-134	443.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23QHR@183939|Methanococci	183939|Methanococci	C	PFAM Nickel-dependent hydrogenase, large subunit	vhuA	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
EH1_k127_2181827_5	1089553.Tph_c09570	3.378e-16	89.0	COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,24DU6@186801|Clostridia,42G65@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM alpha beta hydrolase	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
EH1_k127_2181827_4	1274524.BSONL12_22790	1.083e-24	112.0	COG0454@1|root,COG0456@2|Bacteria,1VFVQ@1239|Firmicutes,4HK5T@91061|Bacilli,1ZIKN@1386|Bacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
EH1_k127_2183848_2	596153.Alide_2255	2.12e-06	60.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2VHXT@28216|Betaproteobacteria,4A9YQ@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
EH1_k127_2183848_3	1307759.JOMJ01000004_gene2859	0.0001997	51.0	COG0727@1|root,COG0727@2|Bacteria,1N9W2@1224|Proteobacteria,42VKK@68525|delta/epsilon subdivisions,2WRG5@28221|Deltaproteobacteria,2MC91@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
EH1_k127_2183848_0	1280941.HY2_13005	9.89e-22	106.0	2EY8I@1|root,33RH3@2|Bacteria,1NS5H@1224|Proteobacteria,2UP0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2183848_1	1499967.BAYZ01000184_gene4603	6.812e-13	72.0	COG0778@1|root,COG0778@2|Bacteria,2NPIF@2323|unclassified Bacteria	2|Bacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH1_k127_2217550_0	1333523.L593_00665	9.7e-51	192.0	COG1874@1|root,arCOG04085@2157|Archaea,2XSU6@28890|Euryarchaeota,23UX4@183963|Halobacteria	183963|Halobacteria	G	COG1874 Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2217550_1	1274402.JQAJ01000002_gene549	6.169e-19	96.0	COG4689@1|root,COG4689@2|Bacteria,1N4IP@1224|Proteobacteria,2TTZX@28211|Alphaproteobacteria,47G14@766|Rickettsiales	766|Rickettsiales	Q	Acetoacetate decarboxylase (ADC)	-	-	4.1.1.4	ko:K01574	ko00072,ko00640,ko01100,map00072,map00640,map01100	M00088	R01366	RC00040	ko00000,ko00001,ko00002,ko01000	-	-	-	ADC
EH1_k127_2254492_2	1349767.GJA_265	6.613e-38	152.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,473Z4@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
EH1_k127_2254492_1	525904.Tter_0449	2.448e-47	196.0	COG0454@1|root,COG0456@2|Bacteria,2NPS0@2323|unclassified Bacteria	2|Bacteria	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.4	ko:K00621	ko00520,map00520	-	R02058	RC00004,RC00166	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,FR47
EH1_k127_2254492_0	439235.Dalk_2834	1.383e-67	248.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,43B2Q@68525|delta/epsilon subdivisions,2WK38@28221|Deltaproteobacteria,2MJTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_2254492_3	565033.GACE_1903	1e-18	93.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
EH1_k127_2262269_0	646529.Desaci_2816	1.953e-45	171.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,264QI@186807|Peptococcaceae	186801|Clostridia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
EH1_k127_2262269_1	444157.Tneu_0939	0.0002615	48.0	COG3432@1|root,arCOG01055@2157|Archaea,2XREG@28889|Crenarchaeota	28889|Crenarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
EH1_k127_2289164_5	374847.Kcr_0681	3.196e-49	185.0	COG1834@1|root,arCOG03109@2157|Archaea	2157|Archaea	E	PFAM amidinotransferase	-	-	3.5.3.18,3.5.3.6	ko:K01478,ko:K01482	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000,ko04147	-	-	-	Amidinotransf
EH1_k127_2289164_6	1121438.JNJA01000002_gene3779	1.209e-30	132.0	2DPHF@1|root,33237@2|Bacteria,1R4GY@1224|Proteobacteria,435JT@68525|delta/epsilon subdivisions,2WZY2@28221|Deltaproteobacteria,2M8FU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
EH1_k127_2289164_2	1232437.KL661965_gene3264	4.718e-110	373.0	COG4819@1|root,COG4819@2|Bacteria,1PPGT@1224|Proteobacteria,42WP6@68525|delta/epsilon subdivisions,2WSCA@28221|Deltaproteobacteria,2MNZT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Ethanolamine utilisation protein EutA	-	-	-	-	-	-	-	-	-	-	-	-	EutA
EH1_k127_2289164_7	247490.KSU1_C1639	3.061e-26	116.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
EH1_k127_2289164_4	234267.Acid_5289	3.43e-59	212.0	COG0800@1|root,COG0800@2|Bacteria,3Y4HZ@57723|Acidobacteria	57723|Acidobacteria	G	2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
EH1_k127_2289164_3	1123508.JH636440_gene1975	5.85e-91	310.0	COG0524@1|root,COG0524@2|Bacteria,2IWUH@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
EH1_k127_2289164_0	748727.CLJU_c11830	1.084e-205	665.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
EH1_k127_2289164_1	584708.Apau_2287	1.205e-110	371.0	COG0436@1|root,COG0436@2|Bacteria,3TAA9@508458|Synergistetes	508458|Synergistetes	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH1_k127_2289164_10	1207063.P24_13368	0.0009359	48.0	COG2345@1|root,COG2345@2|Bacteria,1RIDX@1224|Proteobacteria,2U9M4@28211|Alphaproteobacteria,2JTFX@204441|Rhodospirillales	204441|Rhodospirillales	K	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
EH1_k127_2289164_8	240016.ABIZ01000001_gene1679	5.042e-26	116.0	COG0684@1|root,COG0684@2|Bacteria,46W6B@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
EH1_k127_2289164_9	931626.Awo_c16660	2.421e-11	65.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24BVD@186801|Clostridia,25Y5G@186806|Eubacteriaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
EH1_k127_2322951_0	316274.Haur_3627	1.82e-140	467.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi,37630@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
EH1_k127_2322951_1	479434.Sthe_1188	1.012e-113	391.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi,27Z0B@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
EH1_k127_2339987_0	351160.LRC39	8.539e-44	175.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2N91S@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rad17,Rep_fac_C
EH1_k127_2339987_2	349520.PPE_02936	6.002e-06	59.0	2EDFC@1|root,337BM@2|Bacteria,1VHWX@1239|Firmicutes,4HQ4M@91061|Bacilli,26SME@186822|Paenibacillaceae	91061|Bacilli	S	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
EH1_k127_2339987_1	1123376.AUIU01000011_gene1067	1.92e-07	63.0	COG0620@1|root,COG0620@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
EH1_k127_2347001_1	215803.DB30_2423	2.116e-27	132.0	COG1404@1|root,COG3291@1|root,COG3509@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria,2YZ9E@29|Myxococcales	28221|Deltaproteobacteria	OQ	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8
EH1_k127_2347001_0	504832.OCAR_7510	1.991e-43	169.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3JSY1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH1_k127_2392730_0	1041930.Mtc_0994	1.902e-173	570.0	arCOG03315@1|root,arCOG03315@2157|Archaea,2Y2NW@28890|Euryarchaeota,2NACC@224756|Methanomicrobia	224756|Methanomicrobia	S	DUF3160	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160
EH1_k127_2392730_3	521045.Kole_2071	2.097e-68	246.0	COG0078@1|root,COG0078@2|Bacteria,2GCNA@200918|Thermotogae	200918|Thermotogae	E	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
EH1_k127_2392730_2	403833.Pmob_1731	4.273e-99	334.0	COG0078@1|root,COG0078@2|Bacteria,2GCNA@200918|Thermotogae	200918|Thermotogae	E	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
EH1_k127_2392730_1	1121930.AQXG01000014_gene384	1.175e-113	400.0	COG2366@1|root,COG2366@2|Bacteria,4NEIX@976|Bacteroidetes,1IPU7@117747|Sphingobacteriia	976|Bacteroidetes	S	COG2366 Protein related to penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
EH1_k127_2392730_4	273068.TTE2131	7.847e-67	241.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,42EQG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
EH1_k127_2417350_1	1432050.IE4771_CH00481	8e-36	141.0	COG0863@1|root,COG0863@2|Bacteria,1R832@1224|Proteobacteria,2US0G@28211|Alphaproteobacteria,4B83B@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Protein involved in DNA binding, N-methyltransferase activity and DNA methylation	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
EH1_k127_2417350_2	521011.Mpal_0726	2.938e-21	102.0	COG1309@1|root,arCOG02643@2157|Archaea,2Y6WH@28890|Euryarchaeota,2NB9B@224756|Methanomicrobia	224756|Methanomicrobia	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K03577	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_N
EH1_k127_2417350_0	867845.KI911784_gene1504	9.374e-63	232.0	COG1506@1|root,COG1506@2|Bacteria,2G907@200795|Chloroflexi	200795|Chloroflexi	E	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
EH1_k127_2417350_3	596315.HMPREF0634_0675	0.0007743	49.0	COG1309@1|root,COG1309@2|Bacteria,1TPXF@1239|Firmicutes,24F9Q@186801|Clostridia,25U4T@186804|Peptostreptococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
EH1_k127_2420834_1	515635.Dtur_1163	2.408e-68	246.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
EH1_k127_2420834_2	70601.3257075	2.98e-16	91.0	COG0477@1|root,arCOG00130@2157|Archaea,2XT83@28890|Euryarchaeota,242PX@183968|Thermococci	183968|Thermococci	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_2420834_0	1094508.Tsac_2486	1.219e-126	412.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,42F8D@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
EH1_k127_2449514_43	1416760.AYMS01000039_gene1334	0.0004828	44.0	COG1764@1|root,COG1764@2|Bacteria,4NNF7@976|Bacteroidetes,1I1XV@117743|Flavobacteriia,47J04@76831|Myroides	976|Bacteroidetes	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
EH1_k127_2449514_36	1122137.AQXF01000003_gene2202	1.686e-09	65.0	COG1764@1|root,COG1764@2|Bacteria,1RHVR@1224|Proteobacteria,2VG83@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
EH1_k127_2449514_0	374847.Kcr_1389	2.527e-245	783.0	COG0525@1|root,arCOG00808@2157|Archaea	2157|Archaea	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
EH1_k127_2449514_16	224719.Abm4_0451	2.236e-52	193.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,23NRI@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH1_k127_2449514_32	192952.MM_2352	1.393e-13	74.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y49G@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2449514_1	429009.Adeg_1792	2.386e-155	508.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42FCI@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
EH1_k127_2449514_19	525904.Tter_2260	2.765e-50	192.0	COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
EH1_k127_2449514_14	398767.Glov_0517	1.259e-63	234.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,43TQX@69541|Desulfuromonadales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
EH1_k127_2449514_6	572546.Arcpr_0001	9.546e-122	405.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,245XC@183980|Archaeoglobi	183980|Archaeoglobi	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
EH1_k127_2449514_25	7029.ACYPI008499-PA	5.001e-37	148.0	COG2263@1|root,KOG3420@2759|Eukaryota,39RUZ@33154|Opisthokonta,3BJ3V@33208|Metazoa,3CUUP@33213|Bilateria,41YV7@6656|Arthropoda,3SKYC@50557|Insecta,3EBPV@33342|Paraneoptera	33208|Metazoa	J	Conserved hypothetical protein 95	METTL5	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
EH1_k127_2449514_29	1041930.Mtc_1739	1.402e-26	119.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,2N9T0@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
EH1_k127_2449514_35	634498.mru_0169	3.181e-12	70.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
EH1_k127_2449514_33	69014.TK1166	1.157e-12	74.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
EH1_k127_2449514_28	1343739.PAP_03275	1.638e-27	115.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
EH1_k127_2449514_22	1131266.ARWQ01000001_gene1392	2.545e-39	156.0	COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
EH1_k127_2449514_20	1365176.N186_04465	7.45e-49	192.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
EH1_k127_2449514_39	1459636.NTE_00425	7.53e-07	58.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
EH1_k127_2449514_27	706587.Desti_0171	1.551e-28	121.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
EH1_k127_2449514_11	243232.MJ_0863	2.43e-67	239.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
EH1_k127_2449514_10	351160.LRC437	1.389e-69	251.0	COG1148@1|root,arCOG02236@2157|Archaea,2XV85@28890|Euryarchaeota,2NABC@224756|Methanomicrobia	224756|Methanomicrobia	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3	ko:K22480	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
EH1_k127_2449514_8	1094980.Mpsy_2951	5.228e-93	332.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,2N9AI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
EH1_k127_2449514_5	177437.HRM2_17530	9.424e-122	402.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
EH1_k127_2449514_37	1042877.GQS_10515	1.968e-07	55.0	COG1800@1|root,arCOG07561@1|root,arCOG02164@2157|Archaea,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota,2435K@183968|Thermococci	183968|Thermococci	K	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
EH1_k127_2449514_24	1197477.IA57_08470	3.61e-38	159.0	COG4249@1|root,COG4249@2|Bacteria,4PHQW@976|Bacteroidetes,1I5CW@117743|Flavobacteriia	976|Bacteroidetes	O	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2449514_12	304371.MCP_0749	3.965e-65	232.0	COG1293@1|root,arCOG01695@2157|Archaea	2157|Archaea	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF814,FbpA
EH1_k127_2449514_26	1220534.B655_0574	2.823e-32	129.0	COG0662@1|root,arCOG03003@2157|Archaea,2Y1J0@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
EH1_k127_2449514_3	264732.Moth_1287	3.829e-130	427.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,42FP2@68295|Thermoanaerobacterales	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
EH1_k127_2449514_7	309799.DICTH_0189	5.91e-100	336.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
EH1_k127_2449514_23	573064.Mefer_0238	4.244e-39	149.0	COG1908@1|root,arCOG02475@2157|Archaea,2XXAU@28890|Euryarchaeota,23QYD@183939|Methanococci	183939|Methanococci	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
EH1_k127_2449514_42	269799.Gmet_1663	1.268e-06	61.0	COG0477@1|root,COG2814@2|Bacteria,1QUAS@1224|Proteobacteria,431FD@68525|delta/epsilon subdivisions,2WWTD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_2449514_17	673860.AciM339_0772	9.195e-52	194.0	COG3294@1|root,arCOG04230@2157|Archaea,2XURZ@28890|Euryarchaeota,3F2ZC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
EH1_k127_2449514_34	1151127.KB906326_gene135	1.608e-12	74.0	COG1522@1|root,COG1522@2|Bacteria,1REZH@1224|Proteobacteria,1SAFS@1236|Gammaproteobacteria,1YQ60@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
EH1_k127_2449514_31	698757.Pogu_0039	3.99e-19	93.0	COG1310@1|root,arCOG01138@2157|Archaea,2XRGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
EH1_k127_2449514_41	272557.APE_1161.1	1.084e-06	56.0	COG1369@1|root,arCOG01365@2157|Archaea,2XRE5@28889|Crenarchaeota	28889|Crenarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
EH1_k127_2449514_40	419665.Maeo_1310	7.547e-07	59.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,23QMK@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
EH1_k127_2449514_30	186497.PF1913	2.422e-20	96.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,242JV@183968|Thermococci	183968|Thermococci	J	RNA binding	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
EH1_k127_2449514_15	1343739.PAP_02030	4.983e-63	224.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
EH1_k127_2449514_9	426368.MmarC7_0835	3.444e-86	294.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,23Q9F@183939|Methanococci	183939|Methanococci	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
EH1_k127_2449514_18	760568.Desku_1009	2.202e-51	188.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,2620R@186807|Peptococcaceae	186801|Clostridia	S	DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
EH1_k127_2449514_4	420247.Msm_1164	9.393e-123	405.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,23NMZ@183925|Methanobacteria	183925|Methanobacteria	J	PFAM GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
EH1_k127_2449514_21	1240349.ANGC01000047_gene4661	2.705e-48	179.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria,4G0EJ@85025|Nocardiaceae	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
EH1_k127_2449514_13	1173020.Cha6605_0959	5.216e-65	231.0	COG0508@1|root,COG0508@2|Bacteria,1G4MH@1117|Cyanobacteria	1117|Cyanobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
EH1_k127_2449514_2	290397.Adeh_2295	5.281e-151	488.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,42Y9Q@68525|delta/epsilon subdivisions,2WTQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
EH1_k127_2449514_38	195522.BD01_1811	5.507e-07	63.0	COG1572@1|root,COG3889@1|root,arCOG02497@1|root,arCOG02499@1|root,arCOG02545@1|root,arCOG02554@1|root,arCOG03439@1|root,arCOG01672@2157|Archaea,arCOG02497@2157|Archaea,arCOG02499@2157|Archaea,arCOG02545@2157|Archaea,arCOG02554@2157|Archaea,arCOG03439@2157|Archaea,arCOG07086@2157|Archaea,2XU6I@28890|Euryarchaeota,245EQ@183968|Thermococci	183968|Thermococci	S	solute binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_2488741_0	10224.XP_006816760.1	9.556e-38	156.0	28N5S@1|root,2QUR0@2759|Eukaryota,38D3V@33154|Opisthokonta,3CNNF@33208|Metazoa	33208|Metazoa	T	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
EH1_k127_2562148_0	865861.AZSU01000006_gene1195	6.44e-146	498.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH1_k127_2562148_1	643648.Slip_0136	3.011e-99	331.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,42JSG@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
EH1_k127_2562148_3	264732.Moth_2496	1.152e-20	93.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,25JIA@186801|Clostridia,42HCF@68295|Thermoanaerobacterales	186801|Clostridia	D	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
EH1_k127_2562148_2	47839.CCAU010000011_gene5318	2.59e-52	197.0	COG1237@1|root,COG1237@2|Bacteria,2I8H7@201174|Actinobacteria,23ACA@1762|Mycobacteriaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
EH1_k127_2562148_4	1089544.KB912942_gene4789	8.738e-12	73.0	COG1454@1|root,COG1454@2|Bacteria,2IIBF@201174|Actinobacteria,4EBSP@85010|Pseudonocardiales	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_2564064_5	1499967.BAYZ01000026_gene1636	5.381e-61	215.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
EH1_k127_2564064_10	765420.OSCT_0574	3.183e-39	151.0	COG2050@1|root,COG2050@2|Bacteria,2G9ZQ@200795|Chloroflexi,377IT@32061|Chloroflexia	32061|Chloroflexia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
EH1_k127_2564064_7	368408.Tpen_1582	9.7e-42	165.0	COG5014@1|root,arCOG05120@2157|Archaea,2XPWW@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
EH1_k127_2564064_9	192952.MM_1555	4.849e-41	160.0	COG2220@1|root,arCOG00497@2157|Archaea,2XUPM@28890|Euryarchaeota,2NATF@224756|Methanomicrobia	224756|Methanomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
EH1_k127_2564064_15	29306.JOBE01000010_gene7132	3.793e-06	57.0	COG0500@1|root,COG2226@2|Bacteria,2II3C@201174|Actinobacteria	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
EH1_k127_2564064_12	593750.Metfor_1391	5.801e-11	67.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
EH1_k127_2564064_11	1121011.AUCB01000035_gene869	5.89e-23	115.0	COG1524@1|root,COG1524@2|Bacteria,4NIUS@976|Bacteroidetes,1HZKJ@117743|Flavobacteriia,23HQN@178469|Arenibacter	976|Bacteroidetes	S	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,PA14,Phosphodiest
EH1_k127_2564064_0	402881.Plav_0833	1.07e-157	520.0	COG2730@1|root,COG2730@2|Bacteria,1R5YR@1224|Proteobacteria,2U55F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
EH1_k127_2564064_14	485914.Hmuk_1995	1.105e-07	63.0	COG2120@1|root,arCOG03460@2157|Archaea,2XU80@28890|Euryarchaeota,23TUZ@183963|Halobacteria	183963|Halobacteria	S	proteins, LmbE homologs	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
EH1_k127_2564064_2	760011.Spico_1044	2.324e-80	281.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
EH1_k127_2564064_13	1027273.GZ77_11565	5.045e-08	64.0	COG3255@1|root,COG3255@2|Bacteria,1N206@1224|Proteobacteria,1S8RI@1236|Gammaproteobacteria,1XKS6@135619|Oceanospirillales	135619|Oceanospirillales	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_2564064_1	760011.Spico_1044	8.503e-85	294.0	COG0006@1|root,COG0673@1|root,COG0006@2|Bacteria,COG0673@2|Bacteria,2J6T7@203691|Spirochaetes	203691|Spirochaetes	E	Oxidoreductase family, C-terminal alpha beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
EH1_k127_2564064_6	760011.Spico_1042	4.171e-56	205.0	COG1028@1|root,COG1028@2|Bacteria,2J8GM@203691|Spirochaetes	203691|Spirochaetes	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH1_k127_2564064_4	632292.Calhy_0508	7.116e-71	247.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,24BBC@186801|Clostridia,42GNP@68295|Thermoanaerobacterales	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	fabG4	-	1.1.1.100,1.1.1.304,1.1.1.385,1.1.1.76	ko:K00059,ko:K18009,ko:K19548	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572,M00787	R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R10917,R11671	RC00029,RC00117,RC00154,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH1_k127_2564064_3	760011.Spico_1043	3.273e-78	269.0	COG3246@1|root,COG3246@2|Bacteria	2|Bacteria	K	L-lysine catabolic process to acetate	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
EH1_k127_2564064_16	1280953.HOC_17070	8.682e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,2TTA3@28211|Alphaproteobacteria,43YYS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
EH1_k127_2574352_2	1229909.NSED_06005	5.218e-06	54.0	arCOG03042@1|root,arCOG03042@2157|Archaea	2157|Archaea	KLT	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
EH1_k127_2574352_1	351160.RCIX1006	1.202e-07	63.0	COG1522@1|root,arCOG01586@2157|Archaea	2157|Archaea	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_AsnC-type
EH1_k127_2574352_0	351160.RCIX1281	4.421e-12	75.0	arCOG08019@1|root,arCOG08019@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
EH1_k127_2574352_3	767817.Desgi_0531	6.315e-06	55.0	COG0266@1|root,COG0266@2|Bacteria	2|Bacteria	L	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	fpg	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
EH1_k127_2589275_2	999630.TUZN_0563	5.406e-58	214.0	COG2248@1|root,arCOG00969@2157|Archaea,2XQEH@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
EH1_k127_2589275_3	379066.GAU_2113	1.24e-55	204.0	COG4181@1|root,COG4181@2|Bacteria,1ZUJS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_2589275_6	1184251.TCELL_0428	1.841e-13	72.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
EH1_k127_2589275_4	2850.Phatr22095	3.705e-35	144.0	COG1100@1|root,KOG0098@2759|Eukaryota,2XE6Z@2836|Bacillariophyta	2836|Bacillariophyta	U	Rab subfamily of small GTPases	-	-	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_2589275_1	374847.Kcr_1258	7.178e-96	327.0	COG1363@1|root,arCOG01518@2157|Archaea	2157|Archaea	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
EH1_k127_2589275_0	224324.aq_1763	1.074e-126	415.0	COG1260@1|root,COG1260@2|Bacteria,2G3U0@200783|Aquificae	200783|Aquificae	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
EH1_k127_2589275_7	926690.KE386573_gene2809	1.333e-09	69.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,23S0J@183963|Halobacteria	183963|Halobacteria	L	COG1111 ERCC4-like helicases	hef	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
EH1_k127_2589275_8	69014.TK2277	1.654e-07	61.0	arCOG02103@1|root,arCOG02103@2157|Archaea,2Y0TZ@28890|Euryarchaeota,243RM@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
EH1_k127_2589275_9	1484479.DI14_04125	3.329e-06	57.0	COG4720@1|root,COG4720@2|Bacteria,1V5GD@1239|Firmicutes,4HI8Y@91061|Bacilli	91061|Bacilli	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF-ribofla_trS,ECF_trnsprt
EH1_k127_2589275_10	446471.Xcel_1987	5.585e-06	55.0	2E1T6@1|root,32X32@2|Bacteria,2IR1W@201174|Actinobacteria,4F4VK@85017|Promicromonosporaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4430)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4430
EH1_k127_2589275_5	1396141.BATP01000057_gene2946	6.802e-34	138.0	COG0125@1|root,COG0125@2|Bacteria,46YZ4@74201|Verrucomicrobia,2IUD6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
EH1_k127_2616900_0	639282.DEFDS_1228	1.473e-232	730.0	COG4799@1|root,COG4799@2|Bacteria,2GEP0@200930|Deferribacteres	200930|Deferribacteres	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
EH1_k127_2616900_1	1121405.dsmv_1298	3.396e-121	400.0	COG1032@1|root,COG1032@2|Bacteria,1PTN9@1224|Proteobacteria,42MG9@68525|delta/epsilon subdivisions,2WJYU@28221|Deltaproteobacteria,2MIRY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH1_k127_2616900_2	1212548.B381_00630	1.471e-22	97.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1YZSU@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	COG5016 Pyruvate oxaloacetate carboxyltransferase	oadA	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_5346	Biotin_lipoyl,HMGL-like,PYC_OADA
EH1_k127_2638168_12	43151.ADAC002622-PA	1.443e-08	63.0	COG4886@1|root,KOG0619@2759|Eukaryota,38GJI@33154|Opisthokonta,3BF9C@33208|Metazoa,3CYMA@33213|Bilateria,42BDD@6656|Arthropoda,3SR8W@50557|Insecta,453PY@7147|Diptera,45DNY@7148|Nematocera	33208|Metazoa	T	Leucine-rich immune protein (TM)	-	-	-	ko:K13023,ko:K17256	-	-	-	-	ko00000,ko01002,ko04147	-	-	-	LRR_6,LRR_8
EH1_k127_2638168_7	368407.Memar_1710	3.424e-31	133.0	COG0571@1|root,arCOG03457@2157|Archaea	368407.Memar_1710|-	K	PFAM Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2638168_3	195522.BD01_0598	3.378e-44	181.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2433G@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
EH1_k127_2638168_10	1459636.NTE_01924	1.223e-16	88.0	COG0558@1|root,arCOG00670@2157|Archaea,41SJ7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
EH1_k127_2638168_11	1041930.Mtc_2010	1.428e-16	91.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
EH1_k127_2638168_6	415426.Hbut_0770	6.457e-32	133.0	COG0009@1|root,arCOG01952@2157|Archaea,2XPW0@28889|Crenarchaeota	28889|Crenarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
EH1_k127_2638168_9	368408.Tpen_0214	9.858e-27	116.0	COG1818@1|root,arCOG00084@2157|Archaea,2XRI9@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM THUMP domain protein	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
EH1_k127_2638168_13	309800.C498_18303	7.034e-06	55.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,23W8H@183963|Halobacteria	183963|Halobacteria	S	KEOPS complex Cgi121-like subunit	cgi121	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
EH1_k127_2638168_5	572546.Arcpr_1617	6.183e-39	152.0	COG2236@1|root,arCOG00040@2157|Archaea,2XYCC@28890|Euryarchaeota,247HC@183980|Archaeoglobi	183980|Archaeoglobi	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
EH1_k127_2638168_2	1089553.Tph_c20450	2.947e-130	429.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,42EXG@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
EH1_k127_2638168_1	484770.UFO1_4404	4.342e-168	544.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,4H301@909932|Negativicutes	909932|Negativicutes	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
EH1_k127_2638168_4	304371.MCP_0591	5.059e-42	161.0	arCOG03570@1|root,arCOG03570@2157|Archaea,2XXVH@28890|Euryarchaeota,2NB6B@224756|Methanomicrobia	224756|Methanomicrobia	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
EH1_k127_2638168_8	526227.Mesil_1127	3.991e-31	135.0	2CAQ4@1|root,33YR3@2|Bacteria,1WMW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2638168_0	926567.TheveDRAFT_1198	8.157e-311	964.0	COG2987@1|root,COG2987@2|Bacteria,3TA0F@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
EH1_k127_2653561_0	933801.Ahos_0544	7.589e-40	162.0	COG0377@1|root,arCOG01554@2157|Archaea,2XQCS@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the complex I 20 kDa subunit family	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
EH1_k127_2653561_2	985867.AEWF01000001_gene2147	0.0006963	48.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2U72Q@28211|Alphaproteobacteria,47FH2@766|Rickettsiales	766|Rickettsiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
EH1_k127_2653561_1	1459636.NTE_02553	2.437e-07	56.0	COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
EH1_k127_2663580_3	306264.CUP0505	4.694e-05	49.0	COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2YT80@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	2-oxoglutarate acceptor oxidoreductase	oorC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
EH1_k127_2663580_0	387631.Asulf_01141	8.059e-224	718.0	COG1882@1|root,arCOG06130@2157|Archaea,2XV2I@28890|Euryarchaeota,246S0@183980|Archaeoglobi	183980|Archaeoglobi	C	Glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
EH1_k127_2663580_1	1121382.JQKG01000006_gene3528	6.473e-61	226.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
EH1_k127_2663580_2	1469557.JSWF01000028_gene2848	1.612e-05	55.0	COG0457@1|root,COG0526@1|root,COG0457@2|Bacteria,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1I2TH@117743|Flavobacteriia	976|Bacteroidetes	CO	Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
EH1_k127_2706436_1	665571.STHERM_c17290	1.991e-09	71.0	COG0747@1|root,COG0747@2|Bacteria,2JAFY@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_2706436_0	1150469.RSPPHO_01507	7.788e-12	79.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,2JQ6J@204441|Rhodospirillales	204441|Rhodospirillales	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
EH1_k127_2717449_3	1280941.HY2_11660	1.922e-13	84.0	COG0389@1|root,COG0389@2|Bacteria,1NTDH@1224|Proteobacteria,2UNYG@28211|Alphaproteobacteria,43ZIC@69657|Hyphomonadaceae	28211|Alphaproteobacteria	L	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332,Zn_dep_PLPC
EH1_k127_2717449_1	494419.ALPM01000021_gene33	1.058e-42	171.0	COG0142@1|root,COG0142@2|Bacteria,2IFAW@201174|Actinobacteria,1W9KG@1268|Micrococcaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	crtE	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
EH1_k127_2717449_2	1279038.KB907338_gene953	3.686e-20	104.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JPFJ@204441|Rhodospirillales	204441|Rhodospirillales	S	peptidase U62, modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH1_k127_2717449_0	70601.3256635	9.595e-72	259.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH1_k127_27344_0	1304874.JAFY01000005_gene1647	2.369e-77	272.0	COG0444@1|root,COG0444@2|Bacteria,3TA26@508458|Synergistetes	508458|Synergistetes	P	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
EH1_k127_2750644_2	1041930.Mtc_2045	1.569e-19	94.0	COG2202@1|root,arCOG03931@1|root,arCOG03931@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phage_integrase,Response_reg
EH1_k127_2750644_1	304371.MCP_1255	3.63e-24	106.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota,2NB3N@224756|Methanomicrobia	224756|Methanomicrobia	C	oxidoreductase, delta subunit	porD-2	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
EH1_k127_2750644_0	374847.Kcr_1292	2.564e-102	347.0	COG0674@1|root,arCOG01608@2157|Archaea	2157|Archaea	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	vorA	-	1.2.7.1,1.2.7.7	ko:K00169,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
EH1_k127_2803633_1	930945.SiRe_1967	1.693e-51	192.0	COG0123@1|root,arCOG00324@2157|Archaea,2XQB3@28889|Crenarchaeota	28889|Crenarchaeota	BQ	PFAM Histone deacetylase	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
EH1_k127_2803633_0	552811.Dehly_0080	6.426e-128	415.0	COG0863@1|root,COG0863@2|Bacteria,2GB0Z@200795|Chloroflexi,34DQC@301297|Dehalococcoidia	301297|Dehalococcoidia	H	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH1_k127_2803633_2	304371.MCP_1615	5.656e-34	149.0	COG2202@1|root,arCOG02353@1|root,arCOG02353@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
EH1_k127_2808479_3	1144275.COCOR_07028	8.456e-23	101.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2YUKJ@29|Myxococcales	28221|Deltaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2,4.3.1.1	ko:K01679,ko:K01744	ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R00490,R01082	RC00316,RC00443,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
EH1_k127_2808479_0	877455.Metbo_2113	7.556e-196	625.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
EH1_k127_2808479_2	877455.Metbo_2112	7.241e-59	212.0	COG0479@1|root,arCOG00962@2157|Archaea,2XSXW@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
EH1_k127_2808479_1	1219084.AP014508_gene567	1.68e-141	461.0	COG0334@1|root,COG0334@2|Bacteria,2GCH4@200918|Thermotogae	200918|Thermotogae	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iLJ478.TM1015	ELFV_dehydrog,ELFV_dehydrog_N
EH1_k127_2811102_0	293826.Amet_4762	3.34e-44	183.0	COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,24AYS@186801|Clostridia,36F7X@31979|Clostridiaceae	186801|Clostridia	E	PFAM Peptidase M1, membrane alanine	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
EH1_k127_2820862_5	130081.XP_005708023.1	3.29e-32	130.0	COG1100@1|root,KOG0087@2759|Eukaryota	2759|Eukaryota	J	GTPase activity	-	-	-	ko:K07904,ko:K07905	ko04144,ko04152,ko04961,ko04962,ko04972,map04144,map04152,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_2820862_1	399550.Smar_1111	1.886e-90	311.0	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
EH1_k127_2820862_3	429009.Adeg_0614	1.013e-60	218.0	COG1912@1|root,COG1912@2|Bacteria,1TSR3@1239|Firmicutes,24D3T@186801|Clostridia	186801|Clostridia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
EH1_k127_2820862_7	909663.KI867150_gene1254	2.447e-21	102.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria,2MQMR@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
EH1_k127_2820862_2	373994.Riv7116_3032	6.727e-78	266.0	COG0491@1|root,COG0491@2|Bacteria,1G37T@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_2820862_0	224325.AF_1587	8.133e-170	543.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,245T4@183980|Archaeoglobi	28890|Euryarchaeota	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39,5.3.2.5	ko:K01601,ko:K08965	ko00270,ko00630,ko00710,ko01100,ko01120,ko01200,map00270,map00630,map00710,map01100,map01120,map01200	M00034,M00165,M00166,M00532	R00024,R03140,R07393	RC00172,RC00859,RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
EH1_k127_2820862_6	1047013.AQSP01000140_gene2511	2.219e-31	138.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
EH1_k127_2834485_0	1343739.PAP_07045	2.638e-111	377.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,24339@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
EH1_k127_2834485_2	477974.Daud_1002	1.754e-60	226.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH1_k127_2834485_1	374847.Kcr_1128	2.18e-79	285.0	COG1530@1|root,arCOG00321@2157|Archaea	2157|Archaea	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH1_k127_2835512_3	1313265.JNIE01000010_gene124	2.096e-11	68.0	COG0713@1|root,COG0713@2|Bacteria,2G49Y@200783|Aquificae	200783|Aquificae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
EH1_k127_2835512_2	263358.VAB18032_01360	1.82e-20	97.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria,4DBTZ@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
EH1_k127_2835512_0	1196322.A370_05883	8.939e-68	245.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,24EDV@186801|Clostridia,36UKX@31979|Clostridiaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
EH1_k127_2835512_1	86416.Clopa_2009	1.923e-52	200.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,25E6Z@186801|Clostridia,36EBY@31979|Clostridiaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
EH1_k127_2839515_4	273075.Ta0024	6.5e-09	68.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,241ZP@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_2839515_2	604354.TSIB_1966	2.645e-19	96.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
EH1_k127_2839515_0	1121104.AQXH01000001_gene1902	4.36e-24	118.0	COG2866@1|root,COG2866@2|Bacteria,4NH4I@976|Bacteroidetes	976|Bacteroidetes	E	Peptidase M14	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
EH1_k127_2839515_3	121225.PHUM081740-PA	2.383e-14	85.0	COG4886@1|root,KOG4641@2759|Eukaryota,39TR3@33154|Opisthokonta,3BIK6@33208|Metazoa,3D2U6@33213|Bilateria,41U9B@6656|Arthropoda,3SJQF@50557|Insecta,3E7TI@33342|Paraneoptera	33208|Metazoa	T	TIR domain	TOLL10	-	-	-	-	-	-	-	-	-	-	-	LRR_8,TIR,TIR_2
EH1_k127_2839515_1	450380.JPSY01000004_gene3036	3.75e-22	105.0	COG1387@1|root,COG1387@2|Bacteria,2GMFH@201174|Actinobacteria,4FNA0@85023|Microbacteriaceae	201174|Actinobacteria	E	Helix-hairpin-helix domain	polX	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_8,PHP
EH1_k127_2846447_2	56780.SYN_02213	5.587e-16	87.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
EH1_k127_2846447_0	1122927.KB895413_gene1795	5.92e-50	188.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,4HC44@91061|Bacilli,26QCB@186822|Paenibacillaceae	91061|Bacilli	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	mtnU	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
EH1_k127_2846447_1	192952.MM_2468	1.595e-47	179.0	COG0535@1|root,arCOG00955@2157|Archaea,2Y8D1@28890|Euryarchaeota,2NASP@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
EH1_k127_284819_4	529709.PYCH_00970	1.791e-29	124.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota,243DU@183968|Thermococci	183968|Thermococci	S	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
EH1_k127_284819_2	1120973.AQXL01000084_gene2777	6.719e-86	297.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,4HBTF@91061|Bacilli,2784E@186823|Alicyclobacillaceae	91061|Bacilli	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	iYO844.BSU29710	Hist_deacetyl
EH1_k127_284819_7	177437.HRM2_10900	5.347e-09	66.0	COG2159@1|root,COG2159@2|Bacteria,1Q0A4@1224|Proteobacteria,42Q9N@68525|delta/epsilon subdivisions,2WJTE@28221|Deltaproteobacteria,2MI7C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
EH1_k127_284819_0	374847.Kcr_0279	2.197e-125	421.0	COG1793@1|root,arCOG01347@2157|Archaea	2157|Archaea	F	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
EH1_k127_284819_8	479433.Caci_5557	0.0001673	53.0	COG2519@1|root,COG2519@2|Bacteria,2I55T@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH1_k127_284819_5	224325.AF_1498	2.809e-21	104.0	COG0491@1|root,arCOG00498@2157|Archaea,2Y2RC@28890|Euryarchaeota,246KS@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_284819_3	1094980.Mpsy_0392	1.824e-64	229.0	COG3640@1|root,arCOG00587@2157|Archaea,2XW7J@28890|Euryarchaeota,2N9VV@224756|Methanomicrobia	224756|Methanomicrobia	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
EH1_k127_284819_1	536019.Mesop_4520	3.148e-125	409.0	COG0031@1|root,COG0031@2|Bacteria,1Q4JV@1224|Proteobacteria,2VG8H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH1_k127_2881340_0	439235.Dalk_0164	9.031e-192	623.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
EH1_k127_2881340_1	1499967.BAYZ01000095_gene4068	8.746e-32	127.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
EH1_k127_2885820_2	1042877.GQS_08940	0.0009052	47.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,243GN@183968|Thermococci	183968|Thermococci	H	ATP:dephospho-CoA triphosphoribosyl transferase	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
EH1_k127_2885820_0	985053.VMUT_1854	1.016e-60	218.0	COG0846@1|root,arCOG04248@2157|Archaea,2XQBQ@28889|Crenarchaeota	28889|Crenarchaeota	K	form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
EH1_k127_2885820_1	351160.LRC472	3.129e-10	65.0	COG0576@1|root,arCOG04772@2157|Archaea,2XUCA@28890|Euryarchaeota,2NA0X@224756|Methanomicrobia	224756|Methanomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
EH1_k127_2894177_0	1209989.TepiRe1_1537	1.579e-229	742.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH1_k127_2948918_2	1123373.ATXI01000006_gene242	2.872e-21	106.0	COG0277@1|root,COG0277@2|Bacteria,2GHFQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_2948918_1	589924.Ferp_0942	1.084e-60	224.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
EH1_k127_2948918_0	500153.JOEK01000009_gene5062	4.06e-97	325.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH1_k127_2982724_0	264732.Moth_0445	1.578e-92	313.0	COG2516@1|root,COG2516@2|Bacteria,1TQF6@1239|Firmicutes,24AAS@186801|Clostridia,42GXU@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
EH1_k127_2982724_4	1284352.AOIG01000019_gene3653	3.424e-08	64.0	COG0697@1|root,COG0697@2|Bacteria,1TRJZ@1239|Firmicutes,4HDJI@91061|Bacilli,26R8I@186822|Paenibacillaceae	91061|Bacilli	EG	Permeases of the drug metabolite transporter (DMT) superfamily	yvbV	-	-	-	-	-	-	-	-	-	-	-	EamA
EH1_k127_2982724_1	1304880.JAGB01000002_gene1553	5.071e-79	273.0	COG1814@1|root,COG1814@2|Bacteria,1UZVX@1239|Firmicutes,24BSJ@186801|Clostridia	186801|Clostridia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
EH1_k127_2982724_6	1401065.HMPREF2130_01875	0.000543	50.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,3T4IP@506|Alcaligenaceae	28216|Betaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
EH1_k127_2982724_3	330779.Saci_1059	1.145e-33	145.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRTC@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_2982724_2	457570.Nther_0880	4.554e-38	147.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5
EH1_k127_2990312_0	446468.Ndas_4285	5.332e-05	52.0	COG1266@1|root,COG1266@2|Bacteria,2I8AH@201174|Actinobacteria,4EMCP@85012|Streptosporangiales	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
EH1_k127_302734_2	986075.CathTA2_0103	1.84e-65	231.0	COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli	91061|Bacilli	S	Belongs to the SOS response-associated peptidase family	yoqW	-	-	-	-	-	-	-	-	-	-	-	SRAP
EH1_k127_302734_6	323261.Noc_0787	0.0005726	51.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1X2AD@135613|Chromatiales	135613|Chromatiales	O	Subtilase family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_3_3,Peptidase_S8
EH1_k127_302734_5	1449068.JMLQ01000002_gene3127	3.453e-05	51.0	COG1647@1|root,COG1647@2|Bacteria,2HJV3@201174|Actinobacteria,4G7FC@85025|Nocardiaceae	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_302734_0	660470.Theba_2511	4.773e-189	604.0	COG1233@1|root,COG1233@2|Bacteria,2GDP7@200918|Thermotogae	200918|Thermotogae	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
EH1_k127_302734_1	660470.Theba_2510	1.771e-124	406.0	COG1028@1|root,COG1028@2|Bacteria,2GCF7@200918|Thermotogae	200918|Thermotogae	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
EH1_k127_302734_3	479432.Sros_8893	4.926e-50	196.0	COG0457@1|root,COG3577@1|root,COG0457@2|Bacteria,COG3577@2|Bacteria,2I9VA@201174|Actinobacteria,4EQK0@85012|Streptosporangiales	201174|Actinobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,TPR_16
EH1_k127_3056094_12	1458462.JNLK01000001_gene1142	0.000155	55.0	COG0577@1|root,COG0577@2|Bacteria,1TSP8@1239|Firmicutes,2481U@186801|Clostridia,27INI@186928|unclassified Lachnospiraceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH1_k127_3056094_11	401053.AciPR4_2629	3.98e-05	49.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria,2JK7N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
EH1_k127_3056094_8	1210046.B277_02516	2.157e-08	68.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4FFAH@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ABC transporter	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH1_k127_3056094_3	357808.RoseRS_0179	1.326e-51	196.0	COG1136@1|root,COG2002@1|root,COG1136@2|Bacteria,COG2002@2|Bacteria,2G5S3@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
EH1_k127_3056094_7	240016.ABIZ01000001_gene5187	1.627e-12	81.0	COG1506@1|root,COG1506@2|Bacteria,46UJA@74201|Verrucomicrobia,2IVW2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
EH1_k127_3056094_9	529709.PYCH_02170	2.472e-05	53.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,2448C@183968|Thermococci	183968|Thermococci	L	UPF0292 protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
EH1_k127_3056094_1	411490.ANACAC_02754	4.04e-98	331.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
EH1_k127_3056094_10	335283.Neut_0417	2.472e-05	53.0	COG1765@1|root,COG1765@2|Bacteria,1QXHR@1224|Proteobacteria,2WH4K@28216|Betaproteobacteria,373XY@32003|Nitrosomonadales	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
EH1_k127_3056094_5	694429.Pyrfu_0407	1.915e-27	119.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
EH1_k127_3056094_4	387631.Asulf_01798	1.723e-36	149.0	COG2159@1|root,arCOG01931@2157|Archaea,2XV9F@28890|Euryarchaeota	28890|Euryarchaeota	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
EH1_k127_3056094_2	370438.PTH_1307	9.097e-64	228.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,26144@186807|Peptococcaceae	186801|Clostridia	S	PFAM PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
EH1_k127_3056094_6	415426.Hbut_1112	2.442e-26	113.0	COG0727@1|root,arCOG02579@2157|Archaea,2XR8B@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
EH1_k127_3056094_0	1365176.N186_01910	7.075e-141	462.0	COG1245@1|root,arCOG00187@2157|Archaea,2XPQF@28889|Crenarchaeota	28889|Crenarchaeota	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,Fer4_6,RLI
EH1_k127_3062058_3	1382356.JQMP01000003_gene1374	8.582e-08	67.0	COG2373@1|root,COG2373@2|Bacteria,2GBHR@200795|Chloroflexi,27YXZ@189775|Thermomicrobia	189775|Thermomicrobia	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3062058_1	589924.Ferp_1030	2.188e-14	75.0	COG1487@1|root,arCOG02219@2157|Archaea,2XZ5W@28890|Euryarchaeota,2473H@183980|Archaeoglobi	183980|Archaeoglobi	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
EH1_k127_3062058_2	693661.Arcve_0404	3.766e-13	71.0	COG1753@1|root,arCOG02681@2157|Archaea	2157|Archaea	S	Possibly the antitoxin component of a	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
EH1_k127_3062058_0	272558.10174509	4.992e-45	173.0	28JAJ@1|root,2Z95C@2|Bacteria,1UBFJ@1239|Firmicutes,4HHFM@91061|Bacilli,1ZR76@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3098107_0	1294142.CINTURNW_3871	4.322e-44	176.0	COG1533@1|root,COG1533@2|Bacteria,1TRIS@1239|Firmicutes,25CEW@186801|Clostridia,36WUR@31979|Clostridiaceae	186801|Clostridia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH1_k127_3098107_2	994479.GL877879_gene5205	8.369e-08	57.0	COG2440@1|root,COG2440@2|Bacteria,2IQVY@201174|Actinobacteria	201174|Actinobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO,Fer4_9
EH1_k127_3098107_1	402880.MmarC5_1250	4.234e-16	89.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,23QRM@183939|Methanococci	183939|Methanococci	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,HI0933_like
EH1_k127_3111631_6	338966.Ppro_2905	1.766e-08	57.0	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,43T59@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
EH1_k127_3111631_7	28444.JODQ01000015_gene1770	3.569e-05	49.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4EKJP@85012|Streptosporangiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH1_k127_3111631_5	694429.Pyrfu_1962	1.063e-08	67.0	COG1340@1|root,arCOG01159@2157|Archaea,2XQW7@28889|Crenarchaeota	28889|Crenarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3111631_1	107635.AZUO01000001_gene3075	7.777e-31	134.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria,36Y84@31993|Methylocystaceae	28211|Alphaproteobacteria	HJ	Prokaryotic glutathione synthetase, ATP-grasp domain	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
EH1_k127_3111631_0	416591.Tlet_1486	1.061e-156	514.0	COG0449@1|root,COG0449@2|Bacteria,2GBY1@200918|Thermotogae	200918|Thermotogae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
EH1_k127_3111631_2	243232.MJ_1398	1.838e-20	102.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
EH1_k127_3111631_4	720554.Clocl_1726	4.48e-10	71.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,3WJKQ@541000|Ruminococcaceae	186801|Clostridia	S	basic membrane	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
EH1_k127_3111631_3	272844.PAB1287	3.269e-18	88.0	COG1896@1|root,arCOG04311@2157|Archaea,2XX7G@28890|Euryarchaeota,2440T@183968|Thermococci	183968|Thermococci	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
EH1_k127_3115457_2	1121930.AQXG01000002_gene2040	1.388e-17	93.0	COG1164@1|root,COG1164@2|Bacteria,4NFYH@976|Bacteroidetes,1INVA@117747|Sphingobacteriia	976|Bacteroidetes	E	Oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
EH1_k127_3115457_1	1128421.JAGA01000003_gene3228	1.119e-111	370.0	COG0604@1|root,COG0604@2|Bacteria,2NP5I@2323|unclassified Bacteria	2|Bacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
EH1_k127_3115457_4	1056495.Calag_0838	9.039e-09	64.0	COG3255@1|root,arCOG01842@2157|Archaea,2XR83@28889|Crenarchaeota	28889|Crenarchaeota	K	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_3115457_3	456442.Mboo_2128	1.796e-09	62.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
EH1_k127_3115457_0	589924.Ferp_2103	1.356e-169	555.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,245XW@183980|Archaeoglobi	183980|Archaeoglobi	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_3198684_5	69395.JQLZ01000001_gene3270	0.0008082	51.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2TSQU@28211|Alphaproteobacteria,2KF18@204458|Caulobacterales	204458|Caulobacterales	S	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
EH1_k127_3198684_2	1189620.AJXL01000080_gene788	5.35e-07	60.0	COG1266@1|root,COG1266@2|Bacteria,4NHRW@976|Bacteroidetes,1I1CE@117743|Flavobacteriia,2NVEX@237|Flavobacterium	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH1_k127_3198684_3	1183377.Py04_1403	2.307e-05	55.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,242U5@183968|Thermococci	183968|Thermococci	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
EH1_k127_3198684_0	1163730.FFONT_0035	3.763e-78	271.0	COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
EH1_k127_3198684_4	665956.HMPREF1032_01666	0.0006931	51.0	COG4720@1|root,COG4720@2|Bacteria,1USKD@1239|Firmicutes,24A2K@186801|Clostridia,3WKAY@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
EH1_k127_3198684_1	1460640.JCM19046_4025	1.123e-18	93.0	COG1836@1|root,COG1836@2|Bacteria,1V7I1@1239|Firmicutes,4HD4D@91061|Bacilli,1ZGQ0@1386|Bacillus	91061|Bacilli	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
EH1_k127_3209223_8	273063.STK_20620	1.722e-07	53.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
EH1_k127_3209223_1	309801.trd_1043	2.868e-89	310.0	COG0124@1|root,COG0124@2|Bacteria,2G64E@200795|Chloroflexi,27XH4@189775|Thermomicrobia	189775|Thermomicrobia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
EH1_k127_3209223_5	1227484.C471_13836	6.392e-26	122.0	COG3174@1|root,arCOG04203@2157|Archaea,2XT0W@28890|Euryarchaeota,23S01@183963|Halobacteria	183963|Halobacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
EH1_k127_3209223_6	1365176.N186_02390	7.718e-15	83.0	COG1758@1|root,arCOG01268@2157|Archaea,2XR3X@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03014,ko:K03055	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182,M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
EH1_k127_3209223_0	224325.AF_2238	5.231e-186	597.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,245PX@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
EH1_k127_3209223_2	579137.Metvu_0860	5.563e-42	166.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,23QKP@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
EH1_k127_3209223_3	933801.Ahos_0647	3.911e-38	152.0	COG0456@1|root,arCOG00833@2157|Archaea,2XQJH@28889|Crenarchaeota	28889|Crenarchaeota	S	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
EH1_k127_3209223_4	765177.Desmu_0009	1.439e-33	136.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
EH1_k127_3209223_7	1042877.GQS_07780	6.047e-11	74.0	COG0286@1|root,arCOG04814@1|root,arCOG02632@2157|Archaea,arCOG04814@2157|Archaea,2XVYV@28890|Euryarchaeota	28890|Euryarchaeota	V	COG1002 Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
EH1_k127_3227212_2	1094980.Mpsy_1814	4.725e-63	226.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
EH1_k127_3227212_0	192952.MM_1224	8.726e-139	455.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
EH1_k127_3227212_1	877455.Metbo_0361	1.107e-76	267.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
EH1_k127_3227212_5	877455.Metbo_0358	1.198e-44	170.0	COG4063@1|root,arCOG03221@2157|Archaea,2XWSE@28890|Euryarchaeota,23PC8@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrA	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
EH1_k127_3227212_3	224719.Abm4_1518	1.643e-57	211.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,23PGI@183925|Methanobacteria	183925|Methanobacteria	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
EH1_k127_3227212_4	293826.Amet_2022	9.933e-48	177.0	COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,36UUQ@31979|Clostridiaceae	186801|Clostridia	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
EH1_k127_3240059_1	579137.Metvu_0880	8.159e-80	276.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,23QEM@183939|Methanococci	183939|Methanococci	M	PFAM UDP-N-acetylglucosamine 2-epimerase	-	GO:0003674,GO:0003824,GO:0008761,GO:0016853,GO:0016854,GO:0016857	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
EH1_k127_3240059_4	1227453.C444_01731	8.907e-08	55.0	arCOG02989@1|root,arCOG02989@2157|Archaea,2Y00B@28890|Euryarchaeota,23XHN@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1931
EH1_k127_3240059_2	572478.Vdis_1284	8.478e-49	184.0	COG0496@1|root,arCOG02303@2157|Archaea,2XR4N@28889|Crenarchaeota	28889|Crenarchaeota	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
EH1_k127_3240059_0	604354.TSIB_0767	3.182e-90	309.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,245CI@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
EH1_k127_3240059_3	1123023.JIAI01000006_gene381	1.452e-19	100.0	COG1239@1|root,COG1240@1|root,COG1239@2|Bacteria,COG1240@2|Bacteria,2GN3S@201174|Actinobacteria,4DYER@85010|Pseudonocardiales	201174|Actinobacteria	H	von Willebrand factor, type A	chlI	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
EH1_k127_3255619_18	399549.Msed_2281	6.106e-17	84.0	COG4080@1|root,arCOG01019@2157|Archaea,2XRAB@28889|Crenarchaeota	28889|Crenarchaeota	L	RecB-family nuclease (DUF2122)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2122
EH1_k127_3255619_4	1365176.N186_03105	7.853e-72	254.0	COG0270@1|root,arCOG04157@2157|Archaea,2XPTC@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
EH1_k127_3255619_3	227086.JGI_V11_47453	2.876e-82	286.0	COG1577@1|root,KOG1511@2759|Eukaryota	2759|Eukaryota	I	mevalonate kinase activity	mvk-1	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006066,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006694,GO:0006695,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016126,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653	2.7.1.36,5.4.2.12	ko:K00869,ko:K15633	ko00010,ko00260,ko00680,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04146,map00010,map00260,map00680,map00900,map01100,map01110,map01120,map01130,map01200,map01230,map04146	M00001,M00002,M00003,M00095	R01518,R02245	RC00002,RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
EH1_k127_3255619_2	523850.TON_0392	1.043e-92	319.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
EH1_k127_3255619_1	877455.Metbo_0105	1.875e-103	349.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23NR8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
EH1_k127_3255619_11	1033806.HTIA_0363	5.338e-35	139.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
EH1_k127_3255619_5	399550.Smar_0820	7.957e-72	248.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
EH1_k127_3255619_17	1183377.Py04_1524	1.952e-24	103.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
EH1_k127_3255619_7	634498.mru_0911	2.858e-43	161.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
EH1_k127_3255619_14	70601.3258063	2.482e-31	128.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
EH1_k127_3255619_15	529709.PYCH_02530	9.116e-31	124.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2444E@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
EH1_k127_3255619_6	1041930.Mtc_1534	1.417e-66	236.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
EH1_k127_3255619_21	104355.XP_007862525.1	3.44e-09	65.0	COG1100@1|root,KOG0072@2759|Eukaryota,38G98@33154|Opisthokonta,3NWAZ@4751|Fungi,3UZ35@5204|Basidiomycota,224ZV@155619|Agaricomycetes,3H3HG@355688|Agaricomycetes incertae sedis	4751|Fungi	U	ARF-like small GTPases; ARF, ADP-ribosylation factor	ARL1	GO:0000045,GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006605,GO:0006623,GO:0006810,GO:0006886,GO:0006892,GO:0006893,GO:0006897,GO:0006914,GO:0006950,GO:0006996,GO:0007033,GO:0007034,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0012505,GO:0015031,GO:0015833,GO:0016043,GO:0016192,GO:0016236,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031503,GO:0031984,GO:0032258,GO:0033036,GO:0033365,GO:0033554,GO:0034497,GO:0034613,GO:0034629,GO:0034976,GO:0042886,GO:0043001,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0048193,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0061919,GO:0061951,GO:0070727,GO:0070925,GO:0071702,GO:0071705,GO:0071840,GO:0072594,GO:0072657,GO:0072659,GO:0072665,GO:0072666,GO:0090150,GO:0098657,GO:0098791,GO:0098876,GO:1905037,GO:1990778	-	ko:K07942	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
EH1_k127_3255619_10	453591.Igni_1174	4.636e-36	149.0	COG0371@1|root,arCOG00982@2157|Archaea,2XPMJ@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
EH1_k127_3255619_9	529709.PYCH_03310	4.254e-37	143.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
EH1_k127_3255619_16	1163730.FFONT_0450	1.138e-26	110.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
EH1_k127_3255619_20	330779.Saci_0697	2.092e-13	72.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
EH1_k127_3255619_19	1033806.HTIA_p3006	9.405e-17	95.0	COG0675@1|root,arCOG00679@2157|Archaea,2Y2HC@28890|Euryarchaeota,23Z6G@183963|Halobacteria	183963|Halobacteria	L	Transposase, is605 orfb family	-	-	-	-	-	-	-	-	-	-	-	-	OrfB_Zn_ribbon
EH1_k127_3255619_8	477974.Daud_1911	7.125e-40	155.0	COG2452@1|root,COG2452@2|Bacteria,1UZS8@1239|Firmicutes,24CER@186801|Clostridia,264QZ@186807|Peptococcaceae	186801|Clostridia	L	Resolvase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Resolvase
EH1_k127_3255619_13	1173027.Mic7113_1986	7.913e-32	135.0	COG0105@1|root,COG0105@2|Bacteria,1G4ZN@1117|Cyanobacteria,1HAIY@1150|Oscillatoriales	1117|Cyanobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
EH1_k127_3255619_0	453591.Igni_0001	1.075e-191	616.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
EH1_k127_3255619_12	453591.Igni_1153	1.72e-32	131.0	COG0328@1|root,arCOG02942@2157|Archaea,2XR72@28889|Crenarchaeota	28889|Crenarchaeota	L	Reverse transcriptase-like	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
EH1_k127_3255619_22	1124982.MSI_17970	3.589e-07	57.0	2DMZP@1|root,32UMQ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
EH1_k127_3288231_1	1365176.N186_08305	7.429e-89	307.0	COG0477@1|root,arCOG00134@2157|Archaea	2157|Archaea	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_3288231_0	368407.Memar_2034	7.418e-129	428.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3288231_2	96561.Dole_2014	6.84e-06	57.0	COG1974@1|root,COG3291@1|root,COG4870@1|root,COG1974@2|Bacteria,COG3291@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.2.1.4,3.4.21.88	ko:K01179,ko:K01356,ko:K13735,ko:K21449	ko00500,ko01100,ko05100,map00500,map01100,map05100	M00729	R06200,R11307,R11308	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03400	1.B.40.2	GH5,GH9	-	CHU_C,DUF11,Peptidase_C1,Peptidase_S24
EH1_k127_3290461_0	1220534.B655_0046	2.21e-89	309.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,23PE2@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis	mfnA	-	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
EH1_k127_3290461_4	410358.Mlab_0162	3.132e-28	119.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
EH1_k127_3290461_2	1128421.JAGA01000003_gene3083	1.267e-32	135.0	COG0310@1|root,COG0310@2|Bacteria	2|Bacteria	P	cobalt ion transport	cbiM	-	-	ko:K02007,ko:K16915	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
EH1_k127_3290461_5	207559.Dde_1192	6.939e-10	69.0	COG0619@1|root,COG0619@2|Bacteria,1RJIT@1224|Proteobacteria,42RU5@68525|delta/epsilon subdivisions,2WNB7@28221|Deltaproteobacteria,2MA26@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
EH1_k127_3290461_1	1041930.Mtc_1831	7.389e-56	206.0	COG1122@1|root,arCOG00203@2157|Archaea,2Y7N4@28890|Euryarchaeota,2N9IS@224756|Methanomicrobia	224756|Methanomicrobia	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	iAF692.Mbar_A2149	ABC_tran
EH1_k127_3290461_3	696747.NIES39_D00340	2.665e-30	134.0	COG3608@1|root,COG3608@2|Bacteria,1G167@1117|Cyanobacteria,1H7T8@1150|Oscillatoriales	1117|Cyanobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
EH1_k127_3290461_6	673860.AciM339_0292	1.556e-08	67.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03614@2157|Archaea,2XZI4@28890|Euryarchaeota	28890|Euryarchaeota	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
EH1_k127_3303844_0	459349.CLOAM1781	5.349e-08	68.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K07282,ko:K11005	-	-	-	-	ko00000,ko02000,ko02042	1.C.11	-	-	HemolysinCabind,VCBS
EH1_k127_3305271_0	309799.DICTH_1588	3.828e-124	412.0	COG4952@1|root,COG4952@2|Bacteria	2|Bacteria	M	isomerase activity	xylA_2	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
EH1_k127_3305271_1	1042877.GQS_09785	1.329e-18	98.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota,243WP@183968|Thermococci	183968|Thermococci	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
EH1_k127_3326927_3	688246.Premu_1581	0.000308	49.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,2FNX9@200643|Bacteroidia	976|Bacteroidetes	P	K -dependent Na Ca exchanger family protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
EH1_k127_3326927_0	246969.TAM4_704	3.105e-38	151.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,242US@183968|Thermococci	183968|Thermococci	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
EH1_k127_3326927_2	5759.rna_EHI_169820-1	7.593e-06	56.0	KOG1656@1|root,KOG1656@2759|Eukaryota	2759|Eukaryota	S	vacuolar transport	CHMP4C	GO:0000003,GO:0000070,GO:0000075,GO:0000278,GO:0000280,GO:0000281,GO:0000815,GO:0000819,GO:0000902,GO:0000904,GO:0000910,GO:0000920,GO:0001894,GO:0001919,GO:0003006,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005768,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006620,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0006900,GO:0006914,GO:0006950,GO:0006996,GO:0006997,GO:0006998,GO:0007009,GO:0007032,GO:0007033,GO:0007034,GO:0007040,GO:0007041,GO:0007049,GO:0007059,GO:0007080,GO:0007088,GO:0007093,GO:0007154,GO:0007165,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007346,GO:0007399,GO:0008104,GO:0008150,GO:0008152,GO:0008333,GO:0008356,GO:0008565,GO:0008593,GO:0009056,GO:0009057,GO:0009268,GO:0009405,GO:0009628,GO:0009653,GO:0009838,GO:0009892,GO:0009894,GO:0009895,GO:0009898,GO:0009966,GO:0009968,GO:0009987,GO:0010008,GO:0010035,GO:0010038,GO:0010226,GO:0010256,GO:0010324,GO:0010389,GO:0010458,GO:0010467,GO:0010506,GO:0010507,GO:0010564,GO:0010639,GO:0010646,GO:0010648,GO:0010824,GO:0010941,GO:0010948,GO:0010972,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016021,GO:0016032,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016241,GO:0016242,GO:0016322,GO:0016358,GO:0016485,GO:0017145,GO:0019058,GO:0019068,GO:0019222,GO:0019538,GO:0019899,GO:0019941,GO:0019953,GO:0021700,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023052,GO:0023057,GO:0030030,GO:0030117,GO:0030154,GO:0030163,GO:0030182,GO:0030425,GO:0030447,GO:0030496,GO:0031090,GO:0031175,GO:0031224,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031410,GO:0031468,GO:0031505,GO:0031967,GO:0031975,GO:0031982,GO:0032465,GO:0032466,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032886,GO:0032989,GO:0032990,GO:0032991,GO:0033036,GO:0033043,GO:0033365,GO:0033554,GO:0034059,GO:0034613,GO:0034622,GO:0035690,GO:0036176,GO:0036177,GO:0036178,GO:0036257,GO:0036258,GO:0036293,GO:0036294,GO:0036438,GO:0036452,GO:0036477,GO:0039702,GO:0040007,GO:0040008,GO:0040012,GO:0040017,GO:0042058,GO:0042059,GO:0042078,GO:0042221,GO:0042493,GO:0042551,GO:0042592,GO:0042802,GO:0042803,GO:0042886,GO:0042995,GO:0043005,GO:0043025,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043328,GO:0043632,GO:0043900,GO:0043901,GO:0043902,GO:0043903,GO:0043933,GO:0044085,GO:0044087,GO:0044088,GO:0044126,GO:0044130,GO:0044144,GO:0044146,GO:0044182,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044297,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044878,GO:0045047,GO:0045169,GO:0045184,GO:0045229,GO:0045324,GO:0045746,GO:0045786,GO:0045926,GO:0045930,GO:0046605,GO:0046618,GO:0046755,GO:0046907,GO:0046983,GO:0048132,GO:0048285,GO:0048468,GO:0048469,GO:0048475,GO:0048477,GO:0048518,GO:0048519,GO:0048523,GO:0048524,GO:0048583,GO:0048585,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0048871,GO:0050000,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051117,GO:0051128,GO:0051129,GO:0051179,GO:0051234,GO:0051258,GO:0051259,GO:0051260,GO:0051276,GO:0051301,GO:0051302,GO:0051303,GO:0051310,GO:0051493,GO:0051503,GO:0051603,GO:0051604,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0051704,GO:0051716,GO:0051726,GO:0051782,GO:0051783,GO:0060236,GO:0060249,GO:0060255,GO:0060548,GO:0061024,GO:0061640,GO:0061919,GO:0065003,GO:0065007,GO:0065008,GO:0070482,GO:0070507,GO:0070676,GO:0070727,GO:0070887,GO:0070925,GO:0070938,GO:0070972,GO:0071214,GO:0071241,GO:0071248,GO:0071285,GO:0071453,GO:0071454,GO:0071467,GO:0071554,GO:0071555,GO:0071695,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071852,GO:0071944,GO:0071985,GO:0072594,GO:0072599,GO:0072657,GO:0072665,GO:0072666,GO:0080171,GO:0090148,GO:0090150,GO:0090169,GO:0090224,GO:0090543,GO:0090611,GO:0097320,GO:0097447,GO:0097458,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098722,GO:0098728,GO:0098796,GO:0098805,GO:0098813,GO:0104004,GO:0120025,GO:0120036,GO:0120038,GO:0120039,GO:0140014,GO:1901184,GO:1901185,GO:1901214,GO:1901215,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1901673,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902115,GO:1902116,GO:1902186,GO:1902188,GO:1902749,GO:1902750,GO:1902902,GO:1903047,GO:1903900,GO:1903902,GO:1904669,GO:1990635,GO:2000785	2.1.1.309	ko:K12194,ko:K16075,ko:K17085,ko:K19306	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009,ko04131,ko04147	1.A.35.5	-	-	Snf7
EH1_k127_3326927_1	570268.ANBB01000056_gene14	6.401e-24	111.0	COG0483@1|root,COG0483@2|Bacteria,2GJUM@201174|Actinobacteria,4EMUN@85012|Streptosporangiales	201174|Actinobacteria	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
EH1_k127_3328071_0	632335.Calkr_2254	1.513e-154	503.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,42F0R@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
EH1_k127_3328071_8	401526.TcarDRAFT_1443	7.476e-38	159.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,4H3GY@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
EH1_k127_3328071_2	589924.Ferp_1389	8.858e-100	334.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
EH1_k127_3328071_9	867903.ThesuDRAFT_01499	8.468e-27	117.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
EH1_k127_3328071_4	391623.TERMP_00960	2.442e-84	296.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,24368@183968|Thermococci	183968|Thermococci	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
EH1_k127_3328071_12	263820.PTO0673	5.978e-09	63.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y7BB@28890|Euryarchaeota,242B4@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
EH1_k127_3328071_10	593117.TGAM_0724	4.976e-16	89.0	COG2074@1|root,arCOG01967@2157|Archaea,2Y11V@28890|Euryarchaeota,245CN@183968|Thermococci	183968|Thermococci	F	ATP cone domain	pgk2	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	ATP-cone
EH1_k127_3328071_6	264198.Reut_B4596	1.333e-67	248.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1K035@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
EH1_k127_3328071_7	556269.ACDQ01000011_gene241	1.747e-57	220.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,472IA@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
EH1_k127_3328071_5	648996.Theam_1489	5.652e-78	280.0	COG1008@1|root,COG1008@2|Bacteria,2G4M9@200783|Aquificae	200783|Aquificae	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
EH1_k127_3328071_1	1459636.NTE_02550	1.113e-114	396.0	COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
EH1_k127_3328071_3	436308.Nmar_0284	2.337e-91	319.0	COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota	651137|Thaumarchaeota	C	plastoquinone (complex I)	-	-	1.6.5.3	ko:K00342,ko:K12137,ko:K12141	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
EH1_k127_3328071_11	1121926.AXWO01000029_gene4408	4.463e-14	76.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,4EZPX@85014|Glycomycetales	201174|Actinobacteria	C	4Fe-4S dicluster domain	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
EH1_k127_3335908_0	1226325.HMPREF1548_00758	5.272e-05	48.0	28P2J@1|root,2ZBYK@2|Bacteria,1V6UQ@1239|Firmicutes,249N5@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3796)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3796
EH1_k127_3338391_0	1150626.PHAMO_210078	1.058e-24	118.0	COG0438@1|root,COG0438@2|Bacteria,1PEWW@1224|Proteobacteria,2U2ZQ@28211|Alphaproteobacteria,2JQDK@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
EH1_k127_3338391_1	399739.Pmen_4283	1.454e-12	79.0	COG0438@1|root,COG0438@2|Bacteria,1NBRT@1224|Proteobacteria,1SBVD@1236|Gammaproteobacteria,1YFIX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Glycosyl transferase, group 1	gumI	-	2.4.1.251	ko:K13658,ko:K20999	ko02025,map02025	-	R09734	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glycos_transf_1
EH1_k127_3350173_5	1304284.L21TH_0295	2.327e-31	128.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,36DUF@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_3350173_1	1220534.B655_1154	2.69e-147	488.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
EH1_k127_3350173_4	304371.MCP_1615	1.919e-38	164.0	COG2202@1|root,arCOG02353@1|root,arCOG02353@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
EH1_k127_3350173_7	386456.JQKN01000004_gene231	4.533e-15	79.0	COG2044@1|root,arCOG02066@2157|Archaea,2XWA5@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM DsrE family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,TusA
EH1_k127_3350173_6	638303.Thal_1351	1.602e-21	96.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
EH1_k127_3350173_8	1379701.JPJC01000040_gene1505	1.016e-07	64.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,2K1HR@204457|Sphingomonadales	204457|Sphingomonadales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
EH1_k127_3350173_10	9818.XP_007948257.1	1.081e-05	55.0	COG4886@1|root,KOG0619@2759|Eukaryota,KOG4194@2759|Eukaryota,39JK1@33154|Opisthokonta,3BDMH@33208|Metazoa,3CSI3@33213|Bilateria,489MJ@7711|Chordata,497AN@7742|Vertebrata,3J33P@40674|Mammalia,34T9Q@311790|Afrotheria	33208|Metazoa	T	Leucine-rich repeats and immunoglobulin-like domains	LRIG3	GO:0003674,GO:0005102,GO:0005114,GO:0005126,GO:0005160,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007275,GO:0007423,GO:0008150,GO:0009653,GO:0009719,GO:0009790,GO:0009887,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010453,GO:0010470,GO:0010646,GO:0010647,GO:0016020,GO:0016021,GO:0017015,GO:0022603,GO:0023051,GO:0023052,GO:0023056,GO:0030511,GO:0031224,GO:0031226,GO:0032474,GO:0032501,GO:0032502,GO:0034713,GO:0040008,GO:0040014,GO:0040018,GO:0042221,GO:0042471,GO:0042472,GO:0042659,GO:0042661,GO:0043583,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045927,GO:0045995,GO:0048513,GO:0048518,GO:0048522,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048638,GO:0048639,GO:0048731,GO:0048839,GO:0048840,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051239,GO:0051240,GO:0051716,GO:0065007,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0071944,GO:0090092,GO:0090100,GO:0090287,GO:0090596,GO:1903844,GO:1903846,GO:1905770,GO:1905902,GO:2000026,GO:2000027,GO:2000380	-	-	-	-	-	-	-	-	-	-	I-set,Ig_3,LRRCT,LRR_8
EH1_k127_3350173_11	5679.XP_010699387.1	2.284e-05	57.0	COG4886@1|root,KOG0531@2759|Eukaryota,3XS4M@5653|Kinetoplastida	5653|Kinetoplastida	T	Leucine-rich repeats, typical (most populated) subfamily	-	-	-	-	-	-	-	-	-	-	-	-	LRR_4,LRR_8,LRR_9
EH1_k127_3350173_2	1122132.AQYH01000010_gene4022	5.985e-55	203.0	COG1478@1|root,COG1478@2|Bacteria,1PQHN@1224|Proteobacteria,2TU1P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	F420-0 Gamma-glutamyl ligase	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
EH1_k127_3350173_9	7994.ENSAMXP00000006642	3.973e-07	60.0	KOG1037@1|root,KOG1037@2759|Eukaryota,38B7U@33154|Opisthokonta,3BBUM@33208|Metazoa,3CT5Y@33213|Bilateria,4833Y@7711|Chordata,494V3@7742|Vertebrata,4A1A0@7898|Actinopterygii	33208|Metazoa	KLO	Poly (ADP-ribose) polymerase	PARP1	GO:0000002,GO:0000003,GO:0000122,GO:0000166,GO:0000228,GO:0000302,GO:0000303,GO:0000305,GO:0000715,GO:0000723,GO:0000724,GO:0000725,GO:0000785,GO:0000790,GO:0000791,GO:0000976,GO:0000977,GO:0000981,GO:0001012,GO:0001067,GO:0001228,GO:0001817,GO:0001818,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002225,GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002759,GO:0002760,GO:0002784,GO:0002786,GO:0002791,GO:0002792,GO:0002803,GO:0002805,GO:0002807,GO:0002808,GO:0002831,GO:0002833,GO:0002920,GO:0002922,GO:0003002,GO:0003006,GO:0003254,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0003824,GO:0003909,GO:0003910,GO:0003950,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005667,GO:0005694,GO:0005700,GO:0005703,GO:0005719,GO:0005730,GO:0005737,GO:0005739,GO:0006139,GO:0006140,GO:0006163,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006282,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006296,GO:0006302,GO:0006310,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006464,GO:0006471,GO:0006508,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006963,GO:0006974,GO:0006979,GO:0006996,GO:0006997,GO:0007000,GO:0007005,GO:0007154,GO:0007163,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007389,GO:0007552,GO:0007610,GO:0008069,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009303,GO:0009314,GO:0009408,GO:0009410,GO:0009411,GO:0009416,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009798,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009950,GO:0009953,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010212,GO:0010243,GO:0010332,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010563,GO:0010604,GO:0010605,GO:0010611,GO:0010613,GO:0010628,GO:0010629,GO:0010639,GO:0010646,GO:0010647,GO:0010941,GO:0010942,GO:0010990,GO:0012501,GO:0012505,GO:0014070,GO:0014742,GO:0014743,GO:0015030,GO:0016043,GO:0016070,GO:0016072,GO:0016333,GO:0016334,GO:0016485,GO:0016540,GO:0016604,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016886,GO:0017144,GO:0018130,GO:0018193,GO:0018209,GO:0018312,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019899,GO:0019900,GO:0019901,GO:0019953,GO:0022412,GO:0022414,GO:0022607,GO:0022616,GO:0023019,GO:0023051,GO:0023052,GO:0023056,GO:0030097,GO:0030099,GO:0030154,GO:0030225,GO:0030331,GO:0030534,GO:0030575,GO:0030576,GO:0030707,GO:0030808,GO:0030809,GO:0030855,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0031347,GO:0031349,GO:0031960,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032042,GO:0032101,GO:0032103,GO:0032200,GO:0032204,GO:0032205,GO:0032501,GO:0032502,GO:0032504,GO:0032507,GO:0032660,GO:0032700,GO:0032774,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032991,GO:0032993,GO:0033036,GO:0033043,GO:0033044,GO:0033143,GO:0033145,GO:0033146,GO:0033148,GO:0033365,GO:0033554,GO:0033683,GO:0033993,GO:0034248,GO:0034250,GO:0034504,GO:0034599,GO:0034605,GO:0034613,GO:0034614,GO:0034622,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0034660,GO:0035079,GO:0035080,GO:0035257,GO:0035258,GO:0035363,GO:0036094,GO:0036211,GO:0040008,GO:0040009,GO:0042220,GO:0042221,GO:0042391,GO:0042393,GO:0042493,GO:0042592,GO:0042769,GO:0042802,GO:0042826,GO:0042981,GO:0043067,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043279,GO:0043388,GO:0043412,GO:0043434,GO:0043484,GO:0043502,GO:0043504,GO:0043523,GO:0043565,GO:0043900,GO:0043902,GO:0043933,GO:0044030,GO:0044057,GO:0044085,GO:0044087,GO:0044089,GO:0044093,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044703,GO:0045087,GO:0045185,GO:0045595,GO:0045597,GO:0045739,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045936,GO:0045944,GO:0045980,GO:0046034,GO:0046332,GO:0046483,GO:0047485,GO:0048037,GO:0048148,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048545,GO:0048583,GO:0048584,GO:0048609,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0048878,GO:0050662,GO:0050707,GO:0050708,GO:0050709,GO:0050710,GO:0050776,GO:0050778,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050801,GO:0050879,GO:0050881,GO:0050882,GO:0050896,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051052,GO:0051053,GO:0051054,GO:0051094,GO:0051098,GO:0051099,GO:0051101,GO:0051103,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051235,GO:0051239,GO:0051240,GO:0051241,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051287,GO:0051385,GO:0051427,GO:0051457,GO:0051604,GO:0051606,GO:0051641,GO:0051651,GO:0051704,GO:0051716,GO:0051881,GO:0051900,GO:0051901,GO:0055086,GO:0060249,GO:0060255,GO:0060341,GO:0060359,GO:0060390,GO:0060391,GO:0060429,GO:0062012,GO:0062014,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070212,GO:0070412,GO:0070727,GO:0070848,GO:0070887,GO:0070911,GO:0071214,GO:0071241,GO:0071248,GO:0071294,GO:0071310,GO:0071363,GO:0071375,GO:0071417,GO:0071450,GO:0071451,GO:0071478,GO:0071482,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0071824,GO:0071840,GO:0072347,GO:0072521,GO:0072595,GO:0080090,GO:0080134,GO:0080135,GO:0090087,GO:0090092,GO:0090100,GO:0090257,GO:0090304,GO:0090305,GO:0097159,GO:0097305,GO:0097659,GO:0098687,GO:0098781,GO:0104004,GO:0140096,GO:0140097,GO:0140110,GO:1900180,GO:1900182,GO:1900371,GO:1900372,GO:1900407,GO:1900424,GO:1900426,GO:1900542,GO:1900543,GO:1901135,GO:1901214,GO:1901216,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901652,GO:1901653,GO:1901654,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902175,GO:1902531,GO:1902679,GO:1902680,GO:1902882,GO:1903201,GO:1903203,GO:1903376,GO:1903506,GO:1903507,GO:1903508,GO:1903516,GO:1903518,GO:1903530,GO:1903531,GO:1903578,GO:1903579,GO:1903827,GO:1903829,GO:1904044,GO:1904181,GO:1904356,GO:1904357,GO:1904645,GO:1904646,GO:1904760,GO:1904762,GO:1904950,GO:1905076,GO:1905077,GO:1990404,GO:1990837,GO:1990966,GO:2000112,GO:2000113,GO:2000677,GO:2000679,GO:2001020,GO:2001022,GO:2001141,GO:2001169,GO:2001170,GO:2001233,GO:2001242,GO:2001251	2.4.2.30	ko:K10798	ko03410,ko04210,ko04212,ko04214,ko04217,map03410,map04210,map04212,map04214,map04217	M00296	-	-	ko00000,ko00001,ko00002,ko01000,ko03032,ko03036,ko03400	-	-	-	BRCT,PADR1,PARP,PARP_reg,WGR,zf-PARP
EH1_k127_3350173_0	635013.TherJR_1315	1.194e-172	559.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,260J2@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
EH1_k127_3350173_3	1151116.Q7S_11730	3.737e-53	199.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,3FG4C@34037|Rahnella	1236|Gammaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
EH1_k127_3373740_3	765913.ThidrDRAFT_3582	1.145e-13	81.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1MXJQ@1224|Proteobacteria,1RQIY@1236|Gammaproteobacteria,1WXGP@135613|Chromatiales	135613|Chromatiales	KT	PFAM Stage II sporulation E family protein	-	-	3.1.3.3	ko:K01079,ko:K07315	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03021	-	-	-	GAF,HAMP,SpoIIE,dCache_1
EH1_k127_3373740_0	715451.ambt_20575	7.311e-66	247.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,46466@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	arginine decarboxylase	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283	Orn_Arg_deC_N
EH1_k127_3373740_4	1121123.AUAO01000001_gene1116	9.131e-07	57.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria,2KHJ0@204458|Caulobacterales	204458|Caulobacterales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
EH1_k127_3373740_2	1123371.ATXH01000002_gene379	7.247e-33	133.0	COG0437@1|root,COG0437@2|Bacteria,2GIJ6@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH1_k127_3373740_1	1123376.AUIU01000012_gene1447	2.313e-42	160.0	COG2414@1|root,COG2414@2|Bacteria	2|Bacteria	C	aldehyde ferredoxin oxidoreductase activity	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_3409910_0	4932.YFL039C	5.718e-154	496.0	COG5277@1|root,KOG0676@2759|Eukaryota,38C0D@33154|Opisthokonta,3NWC7@4751|Fungi,3QK5Q@4890|Ascomycota,3RRX1@4891|Saccharomycetes,3RYD3@4893|Saccharomycetaceae	4751|Fungi	Z	Belongs to the actin family	ACT1	GO:0000001,GO:0000003,GO:0000011,GO:0000123,GO:0000132,GO:0000142,GO:0000226,GO:0000228,GO:0000278,GO:0000281,GO:0000785,GO:0000790,GO:0000812,GO:0000910,GO:0000912,GO:0000915,GO:0000916,GO:0001300,GO:0001411,GO:0002790,GO:0003006,GO:0003674,GO:0005198,GO:0005200,GO:0005575,GO:0005622,GO:0005623,GO:0005628,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005826,GO:0005829,GO:0005856,GO:0005884,GO:0005933,GO:0005935,GO:0005937,GO:0005938,GO:0006139,GO:0006259,GO:0006281,GO:0006325,GO:0006338,GO:0006464,GO:0006473,GO:0006475,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006897,GO:0006928,GO:0006950,GO:0006974,GO:0006979,GO:0006996,GO:0007005,GO:0007010,GO:0007017,GO:0007033,GO:0007049,GO:0007114,GO:0007117,GO:0007119,GO:0007163,GO:0007568,GO:0007569,GO:0008104,GO:0008150,GO:0008152,GO:0008360,GO:0009272,GO:0009306,GO:0009653,GO:0009987,GO:0010927,GO:0015031,GO:0015629,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016569,GO:0016570,GO:0016573,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0019953,GO:0019954,GO:0022402,GO:0022413,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0030010,GO:0030029,GO:0030036,GO:0030048,GO:0030050,GO:0030154,GO:0030427,GO:0030435,GO:0030437,GO:0030476,GO:0030479,GO:0030705,GO:0030863,GO:0030864,GO:0030865,GO:0030866,GO:0031011,GO:0031032,GO:0031248,GO:0031505,GO:0031974,GO:0031981,GO:0032153,GO:0032155,GO:0032432,GO:0032502,GO:0032505,GO:0032506,GO:0032940,GO:0032989,GO:0032991,GO:0033036,GO:0033202,GO:0033554,GO:0034293,GO:0034599,GO:0034641,GO:0034728,GO:0035267,GO:0036211,GO:0036213,GO:0040001,GO:0040007,GO:0042221,GO:0042244,GO:0042546,GO:0042763,GO:0042764,GO:0042886,GO:0042995,GO:0043044,GO:0043170,GO:0043189,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043332,GO:0043412,GO:0043486,GO:0043543,GO:0043933,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044451,GO:0044454,GO:0044463,GO:0044464,GO:0044703,GO:0044837,GO:0045184,GO:0045229,GO:0046483,GO:0046903,GO:0046907,GO:0048308,GO:0048311,GO:0048468,GO:0048471,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051179,GO:0051234,GO:0051276,GO:0051286,GO:0051293,GO:0051294,GO:0051301,GO:0051321,GO:0051640,GO:0051641,GO:0051646,GO:0051648,GO:0051649,GO:0051650,GO:0051653,GO:0051656,GO:0051704,GO:0051716,GO:0060303,GO:0061640,GO:0061645,GO:0065007,GO:0065008,GO:0070013,GO:0070590,GO:0070591,GO:0070603,GO:0070726,GO:0070887,GO:0070938,GO:0071554,GO:0071555,GO:0071702,GO:0071704,GO:0071705,GO:0071824,GO:0071840,GO:0071852,GO:0071940,GO:0071944,GO:0071963,GO:0090304,GO:0097346,GO:0098657,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0099515,GO:0099518,GO:0099568,GO:0110085,GO:0120025,GO:0120038,GO:0120104,GO:0120105,GO:0120106,GO:1901360,GO:1901564,GO:1902407,GO:1902410,GO:1902493,GO:1902494,GO:1902562,GO:1902850,GO:1903046,GO:1903047,GO:1903475,GO:1904949,GO:1990234	-	ko:K05692	ko04015,ko04145,ko04210,ko04390,ko04391,ko04510,ko04520,ko04530,ko04611,ko04670,ko04714,ko04745,ko04810,ko04919,ko04921,ko05100,ko05110,ko05130,ko05131,ko05132,ko05164,ko05205,ko05225,ko05410,ko05412,ko05414,ko05416,ko05418,map04015,map04145,map04210,map04390,map04391,map04510,map04520,map04530,map04611,map04670,map04714,map04745,map04810,map04919,map04921,map05100,map05110,map05130,map05131,map05132,map05164,map05205,map05225,map05410,map05412,map05414,map05416,map05418	-	-	-	ko00000,ko00001,ko03019,ko03021,ko03029,ko03036,ko04147,ko04812	-	-	-	Actin
EH1_k127_3409910_4	485913.Krac_10317	8.615e-46	178.0	COG2141@1|root,COG2141@2|Bacteria,2G873@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH1_k127_3409910_3	351160.RCIX623	2.294e-47	176.0	COG1335@1|root,arCOG01943@2157|Archaea	2157|Archaea	Q	COG1335 Amidases related to nicotinamidase	entB1	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
EH1_k127_3409910_8	504728.K649_07695	6.213e-07	62.0	COG0477@1|root,COG2814@2|Bacteria,1WJAR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1,Sugar_tr
EH1_k127_3409910_2	1307761.L21SP2_1835	7.197e-70	245.0	COG0483@1|root,COG0483@2|Bacteria,2J924@203691|Spirochaetes	203691|Spirochaetes	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
EH1_k127_3409910_5	279010.BL03645	4.854e-33	138.0	COG0454@1|root,COG0456@2|Bacteria,1U521@1239|Firmicutes,4HBEJ@91061|Bacilli,1ZCHR@1386|Bacillus	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	ykwB	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_3409910_7	1408424.JHYI01000024_gene1549	1.422e-11	70.0	2E4UP@1|root,32ZP2@2|Bacteria,1UMYM@1239|Firmicutes,4IU3G@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3409910_1	96561.Dole_1695	2.808e-81	284.0	COG1145@1|root,COG1145@2|Bacteria,1MW11@1224|Proteobacteria,42NUY@68525|delta/epsilon subdivisions,2WK01@28221|Deltaproteobacteria,2MMY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH1_k127_3409910_6	1131266.ARWQ01000004_gene1474	1.158e-32	132.0	COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH1_k127_3428644_2	304371.MCP_1125	6.171e-21	98.0	COG0350@1|root,arCOG02724@2157|Archaea,2XZSR@28890|Euryarchaeota,2N9ZT@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
EH1_k127_3428644_8	882083.SacmaDRAFT_2676	8.97e-05	53.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4E0ZE@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Prenyltransferase and squalene oxidase repeat	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
EH1_k127_3428644_5	1343739.PAP_03275	9.485e-07	55.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,2444S@183968|Thermococci	183968|Thermococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
EH1_k127_3428644_1	635013.TherJR_2600	4.721e-91	316.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
EH1_k127_3428644_0	1211035.CD30_09735	1.488e-131	429.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4HATT@91061|Bacilli,3IX8U@400634|Lysinibacillus	91061|Bacilli	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
EH1_k127_3428644_3	517418.Ctha_0236	2.261e-19	104.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	cspBA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
EH1_k127_3428644_7	1336233.JAEH01000001_gene738	8.217e-06	59.0	COG1404@1|root,COG5183@1|root,COG1404@2|Bacteria,COG5183@2|Bacteria,1QU1I@1224|Proteobacteria,1T4GH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3428644_6	374847.Kcr_1143	6.614e-06	56.0	arCOG00743@1|root,arCOG00743@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3428644_4	374847.Kcr_1142	5.879e-08	59.0	arCOG04079@1|root,arCOG04079@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3442545_11	529709.PYCH_07060	2.713e-106	357.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242UT@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
EH1_k127_3442545_22	386456.JQKN01000007_gene3353	3.414e-49	183.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,23NYI@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
EH1_k127_3442545_34	391623.TERMP_01563	1.494e-17	89.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,244FN@183968|Thermococci	183968|Thermococci	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
EH1_k127_3442545_23	1041930.Mtc_2504	3.601e-39	157.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
EH1_k127_3442545_6	572546.Arcpr_1629	1.257e-144	470.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
EH1_k127_3442545_38	70601.3257192	3.331e-14	80.0	COG1813@1|root,arCOG01863@2157|Archaea,2XWZV@28890|Euryarchaeota,242VJ@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
EH1_k127_3442545_28	195522.BD01_1951	3.316e-35	140.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2438P@183968|Thermococci	183968|Thermococci	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
EH1_k127_3442545_25	195522.BD01_1950	8.593e-38	152.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
EH1_k127_3442545_10	515635.Dtur_0462	9.077e-112	375.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	bglB	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
EH1_k127_3442545_37	1217703.F904_01059	9.139e-15	81.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,1S3QT@1236|Gammaproteobacteria,3NK9S@468|Moraxellaceae	1236|Gammaproteobacteria	S	Uncharacterized protein family UPF0016	HA62_23750	-	-	-	-	-	-	-	-	-	-	-	UPF0016
EH1_k127_3442545_8	415426.Hbut_0928	1.232e-118	396.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
EH1_k127_3442545_2	694429.Pyrfu_0957	4.714e-192	619.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
EH1_k127_3442545_13	436308.Nmar_0500	9.961e-98	333.0	COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
EH1_k127_3442545_42	446468.Ndas_0313	0.0003955	50.0	COG4894@1|root,COG4894@2|Bacteria,2GKWI@201174|Actinobacteria,4EPGU@85012|Streptosporangiales	201174|Actinobacteria	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
EH1_k127_3442545_18	693661.Arcve_1321	8.518e-62	220.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2465H@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
EH1_k127_3442545_7	529709.PYCH_06050	6.082e-126	415.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,242R1@183968|Thermococci	183968|Thermococci	V	K homology RNA-binding domain	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
EH1_k127_3442545_35	877455.Metbo_0616	6.552e-17	92.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,23P3J@183925|Methanobacteria	183925|Methanobacteria	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
EH1_k127_3442545_30	1220534.B655_2144	1.481e-25	112.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,23P79@183925|Methanobacteria	183925|Methanobacteria	C	hydrogenase maturation protease HycI	hycI	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
EH1_k127_3442545_14	694429.Pyrfu_1298	5.462e-91	310.0	COG0182@1|root,arCOG01123@2157|Archaea,2XPZU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
EH1_k127_3442545_31	1304880.JAGB01000002_gene1571	1.176e-22	98.0	2E32K@1|root,32Y2U@2|Bacteria,1VFFP@1239|Firmicutes,24RID@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3442545_40	457570.Nther_0339	2.473e-10	70.0	COG3642@1|root,COG3642@2|Bacteria,1VK35@1239|Firmicutes,24RWP@186801|Clostridia	186801|Clostridia	T	lipopolysaccharide core region biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	RIO1
EH1_k127_3442545_4	390874.Tpet_1772	2.76e-173	567.0	COG1743@1|root,COG1743@2|Bacteria	2|Bacteria	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156,N6_N4_Mtase
EH1_k127_3442545_17	926569.ANT_22510	1.621e-63	226.0	COG1028@1|root,COG1028@2|Bacteria,2G6GQ@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.140	ko:K00059,ko:K00068	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05607,R07759,R07763,R10116,R10120,R11671	RC00029,RC00085,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH1_k127_3442545_41	1382303.JPOM01000001_gene1074	9.11e-06	57.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2KG1W@204458|Caulobacterales	204458|Caulobacterales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
EH1_k127_3442545_0	933801.Ahos_0748	0.0	1298.0	COG0085@1|root,arCOG01762@2157|Archaea,2XPRW@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
EH1_k127_3442545_1	644281.MFS40622_1659	0.0	1071.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,23QG8@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Intein_splicing,RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
EH1_k127_3442545_9	272844.PAB0425	2.072e-113	377.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,242U8@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
EH1_k127_3442545_33	985053.VMUT_2061	5.288e-19	91.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
EH1_k127_3442545_27	384616.Pisl_0699	9.785e-37	143.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
EH1_k127_3442545_21	368408.Tpen_0281	1.857e-58	208.0	COG0048@1|root,arCOG04255@2157|Archaea,2XQ79@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
EH1_k127_3442545_19	1365176.N186_02245	3.99e-59	213.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
EH1_k127_3442545_12	1379698.RBG1_1C00001G1614	1.041e-98	335.0	COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
EH1_k127_3442545_3	368408.Tpen_0647	9.938e-182	578.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
EH1_k127_3442545_5	1131266.ARWQ01000001_gene1364	1.597e-150	490.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
EH1_k127_3442545_32	351160.RCIX2041	1.601e-19	91.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,2N9YA@224756|Methanomicrobia	224756|Methanomicrobia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
EH1_k127_3442545_43	1459636.NTE_01468	0.0005555	44.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
EH1_k127_3442545_29	1184251.TCELL_0130	6.402e-26	109.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
EH1_k127_3442545_36	269797.Mbar_A1568	3.003e-15	78.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
EH1_k127_3442545_20	1343739.PAP_03440	5.573e-59	215.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,243FV@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
EH1_k127_3442545_39	384616.Pisl_0432	5.293e-11	64.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
EH1_k127_3442545_16	4513.MLOC_54980.1	5.653e-81	301.0	COG1287@1|root,KOG2292@2759|Eukaryota,37M0F@33090|Viridiplantae,3G8TE@35493|Streptophyta,3KN67@4447|Liliopsida,3IEQK@38820|Poales	35493|Streptophyta	O	Oligosaccharyl transferase STT3 subunit	STT3B	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0071944,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
EH1_k127_3442545_26	498848.TaqDRAFT_4455	1.492e-37	145.0	COG0509@1|root,COG0509@2|Bacteria,1WJYK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
EH1_k127_3442545_15	1118054.CAGW01000078_gene3185	1.718e-87	302.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,26R0E@186822|Paenibacillaceae	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
EH1_k127_3442545_24	1459636.NTE_03213	6.607e-39	154.0	COG0294@1|root,arCOG02817@2157|Archaea,41SGK@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
EH1_k127_3495489_0	604354.TSIB_1748	2.042e-183	585.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,242UA@183968|Thermococci	183968|Thermococci	O	Belongs to the TCP-1 chaperonin family	ths	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
EH1_k127_3495489_1	644107.SL1157_2979	2.122e-111	370.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,4NARQ@97050|Ruegeria	28211|Alphaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
EH1_k127_3497676_10	518766.Rmar_2198	1.97e-08	57.0	COG3255@1|root,COG3255@2|Bacteria,4NYB1@976|Bacteroidetes	976|Bacteroidetes	I	Sterol-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_3497676_2	1265505.ATUG01000001_gene3442	1.867e-84	288.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2MHNA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
EH1_k127_3497676_1	177437.HRM2_38690	1.339e-103	346.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,42Q6C@68525|delta/epsilon subdivisions,2WMD6@28221|Deltaproteobacteria,2MHY6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
EH1_k127_3497676_3	1313172.YM304_28200	1.602e-82	290.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
EH1_k127_3497676_9	521045.Kole_0507	3.782e-14	73.0	COG1522@1|root,COG1522@2|Bacteria,2GEG4@200918|Thermotogae	200918|Thermotogae	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11
EH1_k127_3497676_6	1123371.ATXH01000003_gene1893	2.01e-47	179.0	COG1926@1|root,COG1926@2|Bacteria	2|Bacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
EH1_k127_3497676_7	1265505.ATUG01000002_gene1107	1.799e-35	145.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
EH1_k127_3497676_0	483219.LILAB_22120	2.919e-184	591.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2Z0QK@29|Myxococcales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
EH1_k127_3497676_8	383372.Rcas_2191	8.354e-27	116.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi,3764D@32061|Chloroflexia	32061|Chloroflexia	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
EH1_k127_3497676_5	330214.NIDE2777	2.632e-49	187.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	yddE	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
EH1_k127_3497676_4	926569.ANT_23500	7.333e-74	264.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
EH1_k127_3514760_0	1121468.AUBR01000019_gene2640	1.383e-06	59.0	COG1695@1|root,COG1695@2|Bacteria,1V7D3@1239|Firmicutes,24ME9@186801|Clostridia,42HAY@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
EH1_k127_3515964_0	593117.TGAM_0368	4.248e-56	214.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
EH1_k127_3522315_0	439481.Aboo_0620	6.541e-10	64.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
EH1_k127_3529401_0	224325.AF_1752	1.553e-68	240.0	COG1070@1|root,arCOG00025@2157|Archaea,2Y7I2@28890|Euryarchaeota	28890|Euryarchaeota	G	Belongs to the FGGY kinase family	-	-	2.7.1.17,2.7.1.53	ko:K00854,ko:K00880	ko00040,ko00053,ko01100,map00040,map00053,map01100	M00014	R01639,R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
EH1_k127_3529401_3	862908.BMS_2865	3.621e-12	71.0	COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,42VGM@68525|delta/epsilon subdivisions,2WRJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Excinuclease ABC C subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
EH1_k127_3529401_4	1220534.B655_2110	3.557e-10	71.0	COG0311@1|root,arCOG00034@2157|Archaea	2157|Archaea	F	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	-	-	-	-	-	-	-	-	-	-	-	-	BPL_N
EH1_k127_3529401_1	1178825.ALIH01000019_gene1212	2.17e-22	113.0	COG4625@1|root,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,He_PIG,N_methyl
EH1_k127_353130_0	1209989.TepiRe1_0716	2e-85	297.0	COG2267@1|root,COG2267@2|Bacteria,1UAP5@1239|Firmicutes,24ADQ@186801|Clostridia,42IB9@68295|Thermoanaerobacterales	186801|Clostridia	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
EH1_k127_353130_2	926569.ANT_06990	3.848e-28	117.0	COG2317@1|root,COG2317@2|Bacteria,2G7UQ@200795|Chloroflexi	200795|Chloroflexi	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
EH1_k127_353130_1	240292.Ava_0311	2.407e-56	207.0	COG1028@1|root,COG1028@2|Bacteria,1G7G6@1117|Cyanobacteria,1HQIB@1161|Nostocales	1117|Cyanobacteria	C	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH1_k127_3537285_3	186497.PF2015	2.07e-134	449.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
EH1_k127_3537285_5	1114965.Spaf_1221	7.934e-70	246.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS00835	DeoC
EH1_k127_3537285_1	498761.HM1_0998	1.613e-187	602.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
EH1_k127_3537285_2	192952.MM_0883	1.395e-136	458.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
EH1_k127_3537285_11	926550.CLDAP_02100	2.707e-05	56.0	COG5650@1|root,COG5650@2|Bacteria	2|Bacteria	M	phosphatidylinositol metabolic process	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2,PMT_4TMC
EH1_k127_3537285_6	572546.Arcpr_1573	7.585e-30	124.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,2467U@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
EH1_k127_3537285_10	436308.Nmar_1224	9.226e-07	53.0	arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3537285_0	224325.AF_1297	5.021e-272	855.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,245UG@183980|Archaeoglobi	183980|Archaeoglobi	O	AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
EH1_k127_3537285_7	399550.Smar_0716	3.244e-20	94.0	COG2092@1|root,arCOG01988@2157|Archaea,2XR49@28889|Crenarchaeota	28889|Crenarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
EH1_k127_3537285_8	368408.Tpen_0662	3.107e-14	74.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
EH1_k127_3537285_4	439481.Aboo_0490	3.76e-99	336.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
EH1_k127_3537285_9	374847.Kcr_1446	5.078e-12	72.0	COG3390@1|root,arCOG02258@2157|Archaea	2157|Archaea	S	protein conserved in archaea	rpap1	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	tRNA_anti-codon
EH1_k127_3587586_0	521011.Mpal_1345	2.28e-52	215.0	COG0614@1|root,arCOG03561@1|root,arCOG03561@2157|Archaea,arCOG03611@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
EH1_k127_3587586_1	886293.Sinac_1816	9.485e-32	140.0	COG2304@1|root,COG2304@2|Bacteria,2IY1T@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_3
EH1_k127_3592839_0	1382358.JHVN01000020_gene1372	8.277e-66	239.0	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,4HA5I@91061|Bacilli,21V2W@150247|Anoxybacillus	91061|Bacilli	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
EH1_k127_3593657_2	1304284.L21TH_0262	3.363e-41	160.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,36F9I@31979|Clostridiaceae	186801|Clostridia	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
EH1_k127_3593657_3	1262914.BN533_00304	1.053e-25	117.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4H3ZP@909932|Negativicutes	909932|Negativicutes	S	Serine aminopeptidase, S33	est	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
EH1_k127_3593657_0	485915.Dret_1842	1.347e-119	406.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MAC0@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_3593657_1	63737.Npun_F3215	6.849e-69	241.0	COG0455@1|root,COG0455@2|Bacteria,1G1EJ@1117|Cyanobacteria,1HQDQ@1161|Nostocales	1117|Cyanobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,ParA
EH1_k127_3609734_0	399550.Smar_0236	8.448e-117	390.0	COG0402@1|root,arCOG00695@2157|Archaea,2XPV1@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH1_k127_3610102_2	593117.TGAM_1415	4.867e-20	100.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
EH1_k127_3610102_1	368407.Memar_1073	1.991e-55	203.0	arCOG02449@1|root,arCOG02449@2157|Archaea,2XZ1K@28890|Euryarchaeota,2NAXS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH1_k127_3610102_3	572546.Arcpr_1284	1.043e-05	51.0	COG0526@1|root,arCOG02713@2157|Archaea	2157|Archaea	C	Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0055114	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
EH1_k127_3610102_0	572546.Arcpr_0010	5.476e-105	355.0	COG1328@1|root,COG2074@1|root,arCOG01967@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,NRDD
EH1_k127_3610113_5	591019.Shell_1082	1.437e-41	159.0	COG1571@1|root,arCOG01115@2157|Archaea,2XPN1@28889|Crenarchaeota	28889|Crenarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
EH1_k127_3610113_2	415426.Hbut_0529	1.232e-54	194.0	COG0100@1|root,arCOG04240@2157|Archaea,2XQCR@28889|Crenarchaeota	28889|Crenarchaeota	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
EH1_k127_3610113_4	453591.Igni_0181	8.289e-42	162.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
EH1_k127_3610113_6	1459636.NTE_02226	3.005e-41	158.0	COG0099@1|root,arCOG01722@2157|Archaea,41SIW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
EH1_k127_3610113_0	1284352.AOIG01000014_gene3492	4.313e-66	239.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,4HD98@91061|Bacilli,274UM@186822|Paenibacillaceae	91061|Bacilli	EJ	Asparaginase	ansA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
EH1_k127_3610113_1	1094980.Mpsy_2804	3.958e-60	220.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
EH1_k127_3610113_8	436308.Nmar_0114	2.065e-34	142.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,TrmB
EH1_k127_3610113_3	666510.ASAC_0588	2.511e-50	184.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
EH1_k127_3610113_7	224325.AF_2411	4.811e-39	151.0	COG2141@1|root,arCOG02410@2157|Archaea,2XV6G@28890|Euryarchaeota,246P8@183980|Archaeoglobi	183980|Archaeoglobi	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
EH1_k127_3621139_1	883.DvMF_0393	1.028e-72	263.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7Z@28221|Deltaproteobacteria,2M8HE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
EH1_k127_3621139_2	1337936.IJ00_22020	1.898e-70	252.0	COG0436@1|root,COG0436@2|Bacteria,1G24E@1117|Cyanobacteria,1HMQ7@1161|Nostocales	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
EH1_k127_3621139_0	797209.ZOD2009_02125	1.013e-93	322.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,23SVV@183963|Halobacteria	183963|Halobacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
EH1_k127_3621139_3	1365176.N186_01615	7.949e-62	222.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
EH1_k127_3621139_4	273057.SSO2442	1.007e-09	65.0	COG4352@1|root,arCOG01013@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL13 family	rpl13e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02873	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13e,Ribosomal_L15e
EH1_k127_3621139_5	595460.RRSWK_00445	1.468e-07	63.0	COG0524@1|root,COG0524@2|Bacteria,2J37T@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
EH1_k127_3621139_6	4565.Traes_2DS_0BDFD6AEE.1	4.765e-07	59.0	KOG3330@1|root,KOG3330@2759|Eukaryota,37NAF@33090|Viridiplantae,3G7XM@35493|Streptophyta,3KRZY@4447|Liliopsida,3I3NF@38820|Poales	35493|Streptophyta	U	May play a role in vesicular transport from endoplasmic reticulum to Golgi	-	-	-	ko:K20302	-	-	-	-	ko00000,ko04131	-	-	-	TRAPP
EH1_k127_3628190_4	573064.Mefer_0749	3.194e-20	100.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
EH1_k127_3628190_1	1236689.MMALV_07230	3.197e-102	347.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota	2157|Archaea	E	Cysteine desulfurase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
EH1_k127_3628190_5	397948.Cmaq_0929	1.116e-14	76.0	COG4888@1|root,arCOG04136@2157|Archaea	2157|Archaea	S	PFAM Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
EH1_k127_3628190_7	673860.AciM339_0016	0.0006269	47.0	arCOG05717@1|root,arCOG05717@2157|Archaea,2Y77I@28890|Euryarchaeota,3F3IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3628190_0	1041930.Mtc_0655	4.143e-190	627.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
EH1_k127_3628190_2	523845.AQXV01000053_gene666	6.691e-34	138.0	COG0218@1|root,arCOG00355@2157|Archaea,2XTV8@28890|Euryarchaeota,23QRQ@183939|Methanococci	183939|Methanococci	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
EH1_k127_3628190_6	296587.XP_002503713.1	1.955e-05	52.0	2AM4V@1|root,2RZB5@2759|Eukaryota,37U4I@33090|Viridiplantae,34ISB@3041|Chlorophyta	3041|Chlorophyta	S	Zinc finger SWIM domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
EH1_k127_3628190_3	351160.LRC424	4.123e-32	140.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
EH1_k127_3636099_1	701176.VIBRN418_00436	0.0004807	51.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XT9F@135623|Vibrionales	135623|Vibrionales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
EH1_k127_3636099_0	945713.IALB_0620	2.214e-07	61.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH1_k127_3659752_0	1333523.L593_03640	2.905e-30	128.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,23S1D@183963|Halobacteria	183963|Halobacteria	L	COG0608 Single-stranded DNA-specific exonuclease	recJ1	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
EH1_k127_3659752_1	292459.STH3197	3.46e-25	110.0	COG1051@1|root,COG1051@2|Bacteria,1VH4M@1239|Firmicutes,24T9C@186801|Clostridia	186801|Clostridia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
EH1_k127_3659752_2	744872.Spica_2727	3.491e-10	72.0	COG0457@1|root,COG0457@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
EH1_k127_3686232_0	439481.Aboo_0779	2.224e-07	63.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03607@2157|Archaea	2157|Archaea	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,Big_3_5,NosD,PKD,Peptidase_C1,S_layer_C
EH1_k127_3705434_0	1041930.Mtc_0093	1.452e-84	296.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
EH1_k127_3705434_1	1151117.AJLF01000003_gene625	1.037e-12	70.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244PZ@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
EH1_k127_3705434_2	932678.THERU_01620	4.067e-07	59.0	COG3233@1|root,COG3233@2|Bacteria	2|Bacteria	G	deacetylase	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
EH1_k127_3709008_8	572478.Vdis_1986	1.55e-12	69.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPTF@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
EH1_k127_3709008_6	203122.Sde_2049	9.14e-17	94.0	COG5184@1|root,COG5276@1|root,COG5644@1|root,COG5184@2|Bacteria,COG5276@2|Bacteria,COG5644@2|Bacteria,1QX03@1224|Proteobacteria,1T31Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1_2
EH1_k127_3709008_5	1340493.JNIF01000003_gene1926	7.397e-18	98.0	COG2234@1|root,COG2234@2|Bacteria,3Y43U@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
EH1_k127_3709008_2	1459636.NTE_01027	2.68e-47	188.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
EH1_k127_3709008_4	644282.Deba_1257	1.097e-34	142.0	COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,42RKE@68525|delta/epsilon subdivisions,2WS0D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
EH1_k127_3709008_1	397948.Cmaq_0743	1.701e-52	192.0	COG0163@1|root,arCOG01703@2157|Archaea,2XQJ7@28889|Crenarchaeota	28889|Crenarchaeota	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
EH1_k127_3709008_3	351160.RRC525	5.737e-42	175.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
EH1_k127_3709008_7	436308.Nmar_0257	1.902e-15	83.0	COG1695@1|root,arCOG00002@2157|Archaea,41SN8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
EH1_k127_3709008_0	1521187.JPIM01000086_gene735	4.234e-61	231.0	COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi,3758C@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
EH1_k127_3712888_26	255470.cbdbA127	1.321e-23	113.0	COG3568@1|root,COG3568@2|Bacteria,2G7ER@200795|Chloroflexi,34CM1@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
EH1_k127_3712888_2	429009.Adeg_1885	1.26e-208	686.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
EH1_k127_3712888_35	386456.JQKN01000001_gene1962	7.034e-06	55.0	COG4010@1|root,arCOG04906@2157|Archaea,2XZ3A@28890|Euryarchaeota,23P5J@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized protein conserved in archaea (DUF2096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2096
EH1_k127_3712888_24	1379698.RBG1_1C00001G0621	2.043e-41	161.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,HTH_18,Rhodanese
EH1_k127_3712888_15	1123392.AQWL01000004_gene2612	3.827e-68	248.0	COG0477@1|root,COG2814@2|Bacteria,1RB5E@1224|Proteobacteria,2VQNK@28216|Betaproteobacteria,1KSII@119069|Hydrogenophilales	119069|Hydrogenophilales	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
EH1_k127_3712888_16	386456.JQKN01000001_gene1960	7.5e-68	241.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23NJW@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
EH1_k127_3712888_25	706587.Desti_0171	3.285e-28	120.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
EH1_k127_3712888_22	1041930.Mtc_2472	9.531e-45	188.0	COG1908@1|root,arCOG02475@2157|Archaea,2XY1E@28890|Euryarchaeota,2NAQW@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	mvhD-2	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
EH1_k127_3712888_0	1121472.AQWN01000006_gene1827	5.367e-259	837.0	COG1148@1|root,COG1249@1|root,COG1148@2|Bacteria,COG1249@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,2641A@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
EH1_k127_3712888_33	523850.TON_0956	1.974e-07	63.0	arCOG00391@1|root,arCOG00396@1|root,arCOG00391@2157|Archaea,arCOG00396@2157|Archaea,2Y7YG@28890|Euryarchaeota,243AS@183968|Thermococci	183968|Thermococci	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
EH1_k127_3712888_9	386456.JQKN01000001_gene1960	2.587e-95	321.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23NJW@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	hdrB1	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
EH1_k127_3712888_23	1220534.B655_1684	5.218e-43	167.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
EH1_k127_3712888_13	429009.Adeg_0355	1.097e-79	278.0	COG1180@1|root,COG1180@2|Bacteria,1V170@1239|Firmicutes,24E3W@186801|Clostridia,42HNZ@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
EH1_k127_3712888_18	868131.MSWAN_1553	2.249e-50	184.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,23NZ8@183925|Methanobacteria	183925|Methanobacteria	C	reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_8
EH1_k127_3712888_10	456320.Mvol_0794	4.978e-92	312.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
EH1_k127_3712888_36	1128421.JAGA01000001_gene2345	3.468e-05	56.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CARDB,CBM_3,DUF4091,HYR,Kelch_1,MAM,PA14,PKD,Peptidase_M43,Reprolysin_3
EH1_k127_3712888_27	1459636.NTE_01818	6.871e-21	98.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
EH1_k127_3712888_30	439235.Dalk_1630	2.322e-15	80.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MM2N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
EH1_k127_3712888_4	1121405.dsmv_2339	1.245e-128	421.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MJ1G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
EH1_k127_3712888_31	6087.XP_004207784.1	4.816e-13	79.0	KOG3780@1|root,KOG3780@2759|Eukaryota,38D4U@33154|Opisthokonta,3BJG5@33208|Metazoa	33208|Metazoa	S	negative regulation of heat generation	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0019899,GO:0019902,GO:0019903,GO:0030346,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0060255,GO:0065007	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
EH1_k127_3712888_11	234267.Acid_6989	4.401e-83	284.0	COG1013@1|root,COG1013@2|Bacteria,3Y514@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
EH1_k127_3712888_21	406327.Mevan_0625	6.038e-47	175.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
EH1_k127_3712888_17	1042156.CXIVA_08560	3.777e-65	231.0	COG1775@1|root,COG1924@1|root,COG1775@2|Bacteria,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,36F30@31979|Clostridiaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	hgdC_1	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
EH1_k127_3712888_7	1121422.AUMW01000002_gene2132	2.733e-105	355.0	COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,2493U@186801|Clostridia,260S9@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
EH1_k127_3712888_29	768704.Desmer_1801	4.655e-19	100.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,265AH@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB	-	-	1.3.7.8,4.2.1.54	ko:K04112,ko:K20627	ko00362,ko00640,ko00643,ko01100,ko01120,ko01220,map00362,map00640,map00643,map01100,map01120,map01220	M00541	R02451,R02963	RC00002,RC00818,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
EH1_k127_3712888_1	96561.Dole_0337	2.73e-209	665.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MI8R@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
EH1_k127_3712888_32	1173264.KI913949_gene1508	6.006e-12	79.0	COG1073@1|root,COG1073@2|Bacteria,1G1MU@1117|Cyanobacteria,1HEPN@1150|Oscillatoriales	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
EH1_k127_3712888_20	529709.PYCH_04900	1.857e-47	175.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2439Z@183968|Thermococci	183968|Thermococci	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
EH1_k127_3712888_34	1297742.A176_07293	4.8e-06	58.0	COG1522@1|root,COG1522@2|Bacteria,1N0DP@1224|Proteobacteria,42W6I@68525|delta/epsilon subdivisions,2WSF8@28221|Deltaproteobacteria,2YW31@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
EH1_k127_3712888_3	1191523.MROS_1378	6.349e-162	519.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
EH1_k127_3712888_8	529709.PYCH_08370	6.77e-97	332.0	COG0374@1|root,arCOG01549@2157|Archaea,2Y2IM@28890|Euryarchaeota,2434B@183968|Thermococci	183968|Thermococci	C	Nickel-dependent hydrogenase	-	-	1.12.1.3,1.12.1.5	ko:K17993	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
EH1_k127_3712888_19	156889.Mmc1_0883	4.369e-50	187.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
EH1_k127_3712888_12	1384484.AEQU_0877	3.992e-80	276.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4CV8F@84998|Coriobacteriia	84998|Coriobacteriia	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
EH1_k127_3712888_14	1183377.Py04_1132	1.943e-76	268.0	COG1145@1|root,arCOG05128@2157|Archaea,2XY2U@28890|Euryarchaeota,242VZ@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	1.12.98.4	ko:K17996	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Fer4_22
EH1_k127_3712888_5	368407.Memar_2034	1.953e-110	374.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3712888_6	386415.NT01CX_1206	2.351e-106	368.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36QTE@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_3712888_28	398512.JQKC01000015_gene4671	1.949e-20	98.0	COG1409@1|root,COG1409@2|Bacteria,1UA0Q@1239|Firmicutes,24VZZ@186801|Clostridia	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
EH1_k127_3725307_0	266117.Rxyl_0295	1.535e-126	420.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4CR8G@84995|Rubrobacteria	84995|Rubrobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
EH1_k127_3725307_2	1227453.C444_06781	3.428e-09	66.0	COG0681@1|root,arCOG01739@2157|Archaea,2XX34@28890|Euryarchaeota,23VYJ@183963|Halobacteria	183963|Halobacteria	U	COG0681 Signal peptidase I	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
EH1_k127_3725307_3	888832.HMPREF9420_2860	1.873e-08	62.0	COG2461@1|root,COG2461@2|Bacteria,4NJQA@976|Bacteroidetes,2FTB0@200643|Bacteroidia	976|Bacteroidetes	S	Family of unknown function (DUF438)	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
EH1_k127_3725307_4	1487953.JMKF01000012_gene6262	3.625e-08	66.0	COG0433@1|root,COG0433@2|Bacteria,1GQYY@1117|Cyanobacteria,1HI53@1150|Oscillatoriales	1117|Cyanobacteria	S	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3725307_5	358396.C445_13025	0.0007093	49.0	arCOG06234@1|root,arCOG06234@2157|Archaea,2Y05Z@28890|Euryarchaeota,23XJN@183963|Halobacteria	183963|Halobacteria	CP	Helix-hairpin-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
EH1_k127_3725307_1	523850.TON_1415	2.072e-26	111.0	COG0156@1|root,arCOG00113@2157|Archaea,2XUFG@28890|Euryarchaeota,242SJ@183968|Thermococci	183968|Thermococci	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH1_k127_3769894_0	266117.Rxyl_2848	7.334e-117	384.0	COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4CQAT@84995|Rubrobacteria	84995|Rubrobacteria	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH1_k127_3769894_3	1280390.CBQR020000061_gene1221	4.209e-10	69.0	2AIE8@1|root,33D6T@2|Bacteria,1W2WZ@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3769894_1	1047013.AQSP01000055_gene265	5.605e-42	157.0	COG0251@1|root,COG0251@2|Bacteria,2NPSA@2323|unclassified Bacteria	2|Bacteria	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
EH1_k127_3769894_4	340177.Cag_1344	4.526e-07	59.0	COG0457@1|root,COG0457@2|Bacteria,1FDGV@1090|Chlorobi	1090|Chlorobi	H	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
EH1_k127_3769894_2	410358.Mlab_1491	3.93e-11	74.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,2NB7I@224756|Methanomicrobia	224756|Methanomicrobia	D	Involved in cell shape control	cetZ	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
EH1_k127_3777165_1	768710.DesyoDRAFT_1409	2.541e-62	223.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_3777165_0	439235.Dalk_4976	9.822e-70	249.0	COG1145@1|root,COG1145@2|Bacteria,1MW11@1224|Proteobacteria,42NUY@68525|delta/epsilon subdivisions,2WK01@28221|Deltaproteobacteria,2MMY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH1_k127_3777165_2	379066.GAU_2441	1.001e-37	151.0	COG0500@1|root,COG2226@2|Bacteria,1ZSNE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
EH1_k127_3788451_0	1142394.PSMK_30150	4.89e-31	134.0	COG2159@1|root,COG2159@2|Bacteria,2IYMW@203682|Planctomycetes	203682|Planctomycetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
EH1_k127_3788451_1	1365176.N186_08640	1.759e-20	98.0	arCOG04797@1|root,arCOG04797@2157|Archaea,2XS23@28889|Crenarchaeota	28889|Crenarchaeota	S	retrograde transport, endosome to Golgi	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3795593_2	693661.Arcve_2050	8.888e-22	108.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
EH1_k127_3795593_1	304371.MCP_2203	6.627e-43	169.0	COG1266@1|root,arCOG02766@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH1_k127_3795593_0	255470.cbdbA785	1.57e-145	476.0	COG1233@1|root,COG1233@2|Bacteria,2G5ZA@200795|Chloroflexi,34D93@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
EH1_k127_3802478_1	644966.Tmar_0209	4.928e-76	258.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3WCFP@538999|Clostridiales incertae sedis	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
EH1_k127_3802478_0	1382356.JQMP01000003_gene2339	1.159e-247	781.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi,27XME@189775|Thermomicrobia	189775|Thermomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
EH1_k127_3808509_1	263820.PTO1443	2.799e-31	129.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,241JX@183967|Thermoplasmata	183967|Thermoplasmata	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
EH1_k127_3808509_0	374847.Kcr_1603	1.955e-98	340.0	COG0016@1|root,arCOG00410@2157|Archaea	2157|Archaea	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
EH1_k127_3808509_2	1041930.Mtc_1788	1.317e-26	114.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
EH1_k127_3816513_14	1229276.DI53_2901	0.0003928	52.0	COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes,1IQKB@117747|Sphingobacteriia	976|Bacteroidetes	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc
EH1_k127_3816513_8	1123376.AUIU01000019_gene1303	5.309e-18	89.0	COG0736@1|root,COG0736@2|Bacteria,3J1D9@40117|Nitrospirae	40117|Nitrospirae	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
EH1_k127_3816513_1	234267.Acid_7156	6.512e-120	407.0	COG3882@1|root,COG3882@2|Bacteria	2|Bacteria	Q	phosphopantetheine binding	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3816513_13	1125971.ASJB01000080_gene7251	6.247e-07	53.0	COG0236@1|root,COG0236@2|Bacteria,2GQSX@201174|Actinobacteria,4E71Q@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
EH1_k127_3816513_7	596151.DesfrDRAFT_2462	2.61e-20	96.0	COG0110@1|root,COG0110@2|Bacteria,1MZV9@1224|Proteobacteria,42PR0@68525|delta/epsilon subdivisions,2WMBK@28221|Deltaproteobacteria,2M8E3@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,Hexapep,Hexapep_2
EH1_k127_3816513_12	662479.C440_00540	1.899e-12	77.0	COG0726@1|root,arCOG02876@2157|Archaea,2XSWA@28890|Euryarchaeota,23S47@183963|Halobacteria	183963|Halobacteria	G	xylanase chitin deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
EH1_k127_3816513_9	698757.Pogu_1728	5.371e-18	88.0	COG1257@1|root,arCOG05512@2157|Archaea,2XSJX@28889|Crenarchaeota	28889|Crenarchaeota	I	hydroxymethylglutaryl-CoA reductase (NADPH) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3816513_4	1499967.BAYZ01000147_gene686	8.474e-80	278.0	COG1063@1|root,COG1063@2|Bacteria,2NQVE@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	ydjL	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
EH1_k127_3816513_6	760568.Desku_0323	3.184e-23	104.0	COG0599@1|root,COG0599@2|Bacteria,1VFY0@1239|Firmicutes,25CIE@186801|Clostridia,2631D@186807|Peptococcaceae	186801|Clostridia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
EH1_k127_3816513_5	1042877.GQS_06330	5.509e-28	123.0	COG0095@1|root,arCOG01939@2157|Archaea,2XUJ0@28890|Euryarchaeota,2451A@183968|Thermococci	183968|Thermococci	H	Biotin/lipoate A/B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
EH1_k127_3816513_3	1347087.CBYO010000016_gene2564	1.307e-84	296.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,4HDFT@91061|Bacilli	91061|Bacilli	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
EH1_k127_3816513_0	1121472.AQWN01000007_gene1130	1.38e-120	394.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
EH1_k127_3816513_2	1121445.ATUZ01000020_gene2123	4.75e-100	336.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MATV@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Dehydrogenase, E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
EH1_k127_3816513_11	42256.RradSPS_0122	2.973e-14	83.0	COG0500@1|root,COG2226@2|Bacteria,2I35J@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
EH1_k127_3816513_10	1184251.TCELL_0968	5.308e-15	86.0	arCOG04555@1|root,arCOG04555@2157|Archaea	2157|Archaea	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
EH1_k127_3826373_0	891968.Anamo_1805	1.812e-56	213.0	COG0477@1|root,COG2814@2|Bacteria,3TAXB@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
EH1_k127_3835552_2	1262449.CP6013_1416	2.218e-17	85.0	COG4997@1|root,COG4997@2|Bacteria,1VEG6@1239|Firmicutes,24QRF@186801|Clostridia,36KRV@31979|Clostridiaceae	186801|Clostridia	S	phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF429,MazG-like
EH1_k127_3835552_0	573064.Mefer_0209	2.852e-152	501.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23QS4@183939|Methanococci	183939|Methanococci	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
EH1_k127_3835552_1	1151292.QEW_3660	6.73e-53	198.0	COG0384@1|root,COG0384@2|Bacteria,1TRAF@1239|Firmicutes,25D2F@186801|Clostridia	186801|Clostridia	S	Phenazine biosynthesis protein, PhzF family	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
EH1_k127_3842503_1	1382306.JNIM01000001_gene3950	1.991e-97	341.0	COG0383@1|root,COG0383@2|Bacteria,2G5U7@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
EH1_k127_3842503_0	368408.Tpen_1350	1.084e-123	404.0	COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota	28889|Crenarchaeota	E	carboxypeptidase activity	-	-	-	ko:K12941,ko:K13048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
EH1_k127_3891198_1	195522.BD01_0748	7.08e-107	361.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,242X6@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
EH1_k127_3891198_0	693661.Arcve_1203	1.692e-159	512.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
EH1_k127_3897275_1	456442.Mboo_1043	3.158e-59	216.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
EH1_k127_3897275_3	439235.Dalk_0147	8.84e-47	179.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2MKKR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
EH1_k127_3897275_0	706587.Desti_2453	1.112e-101	342.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2MQSA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
EH1_k127_3897275_4	697303.Thewi_2684	3.495e-06	59.0	COG0738@1|root,COG0738@2|Bacteria,1UJ6C@1239|Firmicutes,2494T@186801|Clostridia	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	ko:K18214	-	-	-	-	ko00000,ko01504,ko02000	2.A.1.21.6	-	-	MFS_1
EH1_k127_3897275_2	1168059.KB899087_gene2594	1.072e-52	196.0	COG1478@1|root,COG1478@2|Bacteria,1PQHN@1224|Proteobacteria,2TU1P@28211|Alphaproteobacteria,3F0WC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	F420-0:Gamma-glutamyl ligase	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
EH1_k127_3899202_0	1294265.JCM21738_2818	2.554e-09	69.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	tetA_3	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
EH1_k127_392020_5	1390370.O203_07450	2.694e-08	64.0	COG0697@1|root,COG0697@2|Bacteria,1N024@1224|Proteobacteria,1S1KP@1236|Gammaproteobacteria,1YHF6@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH1_k127_392020_3	242159.ABO95910	1.571e-17	95.0	COG2012@1|root,KOG3218@2759|Eukaryota,37R44@33090|Viridiplantae,34HM8@3041|Chlorophyta	3041|Chlorophyta	K	RNA polymerase Rpb5, C-terminal domain	-	-	-	ko:K03013	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb5_C,RNA_pol_Rpb5_N
EH1_k127_392020_2	317936.Nos7107_1714	5.579e-19	97.0	COG0170@1|root,COG0170@2|Bacteria,1GJ5N@1117|Cyanobacteria,1HMBV@1161|Nostocales	1117|Cyanobacteria	I	PFAM phosphatidate cytidylyltransferase	-	-	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	-
EH1_k127_392020_0	383372.Rcas_3269	1.805e-53	201.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi,374WE@32061|Chloroflexia	2|Bacteria	S	PFAM molybdopterin binding domain	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
EH1_k127_392020_1	903818.KI912268_gene1371	6.11e-23	108.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
EH1_k127_392020_4	1499967.BAYZ01000154_gene1533	7.581e-09	59.0	COG0084@1|root,COG0084@2|Bacteria,2NP9H@2323|unclassified Bacteria	2|Bacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
EH1_k127_3934169_0	1499967.BAYZ01000033_gene1129	1.984e-100	337.0	COG1741@1|root,COG1741@2|Bacteria,2NRU4@2323|unclassified Bacteria	2|Bacteria	S	Pirin	yhhW	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
EH1_k127_3934169_3	1280673.AUJJ01000036_gene1540	8.015e-19	92.0	COG1433@1|root,COG1433@2|Bacteria,1UX90@1239|Firmicutes,25KXQ@186801|Clostridia,4C19J@830|Butyrivibrio	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
EH1_k127_3934169_2	1123257.AUFV01000007_gene297	3.426e-28	118.0	COG4319@1|root,COG4319@2|Bacteria,1NHKV@1224|Proteobacteria,1T8CF@1236|Gammaproteobacteria,1XAF3@135614|Xanthomonadales	135614|Xanthomonadales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
EH1_k127_3934169_1	671143.DAMO_1522	4.089e-50	187.0	COG2267@1|root,COG2267@2|Bacteria,2NPTF@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	mhpC	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
EH1_k127_3941572_3	536233.CLO_1788	2.621e-13	74.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247V6@186801|Clostridia,36F0S@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
EH1_k127_3941572_1	1463909.KL585951_gene2295	1.623e-19	98.0	COG2755@1|root,COG3507@1|root,COG2755@2|Bacteria,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydr_30_2,Glyco_hydro_43,Glyco_hydro_97,Laminin_G_3,Lipase_GDSL_2,RicinB_lectin_2
EH1_k127_3941572_0	313596.RB2501_11342	3.165e-107	353.0	COG3246@1|root,COG3246@2|Bacteria,4NGNQ@976|Bacteroidetes,1I7AI@117743|Flavobacteriia	976|Bacteroidetes	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
EH1_k127_3941572_2	1296415.JACC01000006_gene1472	5.219e-15	82.0	2E6PT@1|root,331A4@2|Bacteria,4NVEZ@976|Bacteroidetes,1I5S3@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_3985451_3	1385518.N798_15465	6.338e-28	122.0	COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria,4FIIB@85021|Intrasporangiaceae	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
EH1_k127_3985451_1	1444711.CCJF01000005_gene546	5.159e-112	397.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
EH1_k127_3985451_4	316274.Haur_2819	3.546e-13	84.0	COG3266@1|root,COG3266@2|Bacteria,2G7UN@200795|Chloroflexi,377BD@32061|Chloroflexia	32061|Chloroflexia	K	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3985451_2	368408.Tpen_1575	3.343e-59	219.0	COG0111@1|root,arCOG01757@2157|Archaea	2157|Archaea	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA2	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
EH1_k127_3985451_0	1094980.Mpsy_3151	3.244e-181	630.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_3988078_6	880073.Calab_1834	1.111e-13	82.0	COG4285@1|root,COG4285@2|Bacteria	2|Bacteria	S	Biotin-protein ligase, N terminal	CP_0643	-	-	-	-	-	-	-	-	-	-	-	BPL_N
EH1_k127_3988078_9	1120971.AUCA01000019_gene1085	9.877e-06	54.0	COG0500@1|root,COG2226@2|Bacteria,1VDPJ@1239|Firmicutes,4IQF5@91061|Bacilli,278IU@186823|Alicyclobacillaceae	91061|Bacilli	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
EH1_k127_3988078_5	1121324.CLIT_10c02430	4.18e-19	90.0	COG0500@1|root,COG2226@2|Bacteria,1V3EF@1239|Firmicutes,24IK6@186801|Clostridia,25TEK@186804|Peptostreptococcaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA,Methyltransf_11
EH1_k127_3988078_3	1410653.JHVC01000007_gene628	2.374e-44	175.0	COG0500@1|root,COG2226@2|Bacteria,1UFKC@1239|Firmicutes,24H53@186801|Clostridia,36I5D@31979|Clostridiaceae	186801|Clostridia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
EH1_k127_3988078_8	31234.CRE11671	1.686e-09	68.0	KOG3780@1|root,KOG3780@2759|Eukaryota,38D4U@33154|Opisthokonta,3BJG5@33208|Metazoa,3CY15@33213|Bilateria,40GB5@6231|Nematoda,1KZ3I@119089|Chromadorea,40Z6M@6236|Rhabditida	33208|Metazoa	S	mRNA, complete cds	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0060255,GO:0065007	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
EH1_k127_3988078_2	309807.SRU_1720	3.086e-52	196.0	COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1FK37@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
EH1_k127_3988078_4	1384066.JAGT01000001_gene618	1.636e-33	143.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia,3WNFR@541000|Ruminococcaceae	186801|Clostridia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
EH1_k127_3988078_0	264732.Moth_0443	3.474e-145	477.0	COG0095@1|root,COG1852@1|root,COG0095@2|Bacteria,COG1852@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,42ET4@68295|Thermoanaerobacterales	186801|Clostridia	H	biotin lipoate A B protein ligase	lipM	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
EH1_k127_3988078_1	882083.SacmaDRAFT_1928	8.414e-80	278.0	COG1856@1|root,COG1856@2|Bacteria,2H3RG@201174|Actinobacteria	201174|Actinobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
EH1_k127_3988078_7	1051632.TPY_0763	5.569e-12	68.0	COG2516@1|root,COG2516@2|Bacteria,1TQF6@1239|Firmicutes,24AAS@186801|Clostridia	186801|Clostridia	S	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
EH1_k127_4002688_2	1123371.ATXH01000004_gene1732	3.703e-30	122.0	COG0115@1|root,COG0115@2|Bacteria,2GHRV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
EH1_k127_4002688_1	589924.Ferp_2333	4.441e-36	142.0	COG0437@1|root,arCOG01500@2157|Archaea	2157|Archaea	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_6
EH1_k127_4002688_0	868595.Desca_0853	1.415e-147	488.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260VN@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_4002688_5	339860.Msp_1119	1.676e-20	97.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,23PNF@183925|Methanobacteria	183925|Methanobacteria	L	excinuclease ABC, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
EH1_k127_4002688_3	420247.Msm_0190	4.093e-28	126.0	COG1365@1|root,arCOG00045@2157|Archaea,2XVQG@28890|Euryarchaeota,23NNR@183925|Methanobacteria	183925|Methanobacteria	S	PFAM ExsB family protein	-	-	-	ko:K07134	-	-	-	-	ko00000	-	-	-	-
EH1_k127_4002688_4	66377.JOBH01000006_gene226	1.339e-20	103.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria	201174|Actinobacteria	S	Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_4010640_0	335543.Sfum_3098	9.362e-65	227.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria,2MQ7K@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Amino-transferase class IV	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_2853	Aminotran_4
EH1_k127_4014170_2	572478.Vdis_1036	1.545e-31	130.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
EH1_k127_4014170_3	311424.DhcVS_460	1.172e-23	115.0	COG0842@1|root,COG0842@2|Bacteria,2G8VC@200795|Chloroflexi,34CVU@301297|Dehalococcoidia	301297|Dehalococcoidia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
EH1_k127_4014170_4	1280947.HY30_05735	3.121e-12	71.0	COG1846@1|root,COG1846@2|Bacteria,1RJ4D@1224|Proteobacteria,2U9KA@28211|Alphaproteobacteria,43Y57@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Winged helix DNA-binding domain	MA20_05735	-	-	-	-	-	-	-	-	-	-	-	HTH_34
EH1_k127_4014170_1	555079.Toce_2076	9.221e-43	162.0	COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia,42GT3@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_4014170_5	314265.R2601_19457	1.453e-07	59.0	COG0454@1|root,COG0456@2|Bacteria,1RIS8@1224|Proteobacteria,2UCZ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
EH1_k127_4014170_0	673860.AciM339_1556	2.867e-103	351.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,3F2ZN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
EH1_k127_4014170_6	335543.Sfum_2286	0.0001485	52.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
EH1_k127_4017422_30	1526927.Plano_1571	0.0003352	48.0	COG1409@1|root,COG1409@2|Bacteria,1VHY9@1239|Firmicutes,4HPAR@91061|Bacilli	91061|Bacilli	S	Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
EH1_k127_4017422_25	339860.Msp_0545	2.666e-10	69.0	arCOG06454@1|root,arCOG06454@2157|Archaea,2XWG7@28890|Euryarchaeota,23NTT@183925|Methanobacteria	183925|Methanobacteria	S	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	RNase_Zc3h12a
EH1_k127_4017422_1	665571.STHERM_c07990	2.46e-224	709.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
EH1_k127_4017422_23	604354.TSIB_1018	2.02e-14	82.0	COG1392@1|root,arCOG02640@2157|Archaea,2XWHY@28890|Euryarchaeota,242W3@183968|Thermococci	183968|Thermococci	K	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
EH1_k127_4017422_20	765910.MARPU_02055	9.537e-31	134.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1WX8S@135613|Chromatiales	135613|Chromatiales	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
EH1_k127_4017422_18	945713.IALB_1881	1.709e-32	136.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
EH1_k127_4017422_13	1303518.CCALI_00908	3.605e-42	160.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	tdsD	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH1_k127_4017422_3	1121472.AQWN01000003_gene1546	6.3e-145	470.0	COG1960@1|root,COG1960@2|Bacteria,1TRR9@1239|Firmicutes,24AJB@186801|Clostridia,260H9@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
EH1_k127_4017422_24	1291050.JAGE01000002_gene3572	1.393e-13	75.0	COG0716@1|root,COG1146@1|root,COG0716@2|Bacteria,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Flavodoxin_3,Flavodoxin_5
EH1_k127_4017422_9	368408.Tpen_1546	2.297e-51	194.0	arCOG10919@1|root,arCOG10919@2157|Archaea	368408.Tpen_1546|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4017422_6	694430.Natoc_0851	1.733e-60	222.0	COG0697@1|root,arCOG00271@2157|Archaea,2XY2J@28890|Euryarchaeota,23Z1Z@183963|Halobacteria	183963|Halobacteria	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH1_k127_4017422_26	797302.Halru_0959	2.202e-09	66.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XWRN@28890|Euryarchaeota,23VH4@183963|Halobacteria	183963|Halobacteria	K	DNA binding	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
EH1_k127_4017422_0	926569.ANT_18080	2.708e-293	913.0	COG0021@1|root,COG0021@2|Bacteria,2G63Z@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
EH1_k127_4017422_27	604354.TSIB_1246	1.851e-06	55.0	arCOG03769@1|root,arCOG03769@2157|Archaea,2Y4FT@28890|Euryarchaeota,244NG@183968|Thermococci	183968|Thermococci	M	glucosylceramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4017422_11	387631.Asulf_01218	7.072e-47	171.0	COG2033@1|root,arCOG02146@2157|Archaea,2Y3EA@28890|Euryarchaeota	28890|Euryarchaeota	C	Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide	sorA	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
EH1_k127_4017422_5	523845.AQXV01000038_gene1117	9.416e-92	321.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,23QKS@183939|Methanococci	183939|Methanococci	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH1_k127_4017422_19	368408.Tpen_1668	5.998e-31	133.0	COG4720@1|root,arCOG05752@2157|Archaea,2XQ9C@28889|Crenarchaeota	28889|Crenarchaeota	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
EH1_k127_4017422_2	1499967.BAYZ01000180_gene4413	6.9e-168	539.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4017422_29	880073.Calab_1548	0.000144	50.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
EH1_k127_4017422_17	1156937.MFUM_160005	7.753e-35	138.0	COG1881@1|root,COG1881@2|Bacteria,46T05@74201|Verrucomicrobia,37GQM@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
EH1_k127_4017422_4	679926.Mpet_2685	2.545e-144	470.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,2NADB@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
EH1_k127_4017422_16	103690.17133313	1.297e-37	155.0	COG0438@1|root,COG0438@2|Bacteria,1G0YI@1117|Cyanobacteria,1HIQK@1161|Nostocales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	rfaG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
EH1_k127_4017422_8	926550.CLDAP_25410	2.176e-56	204.0	COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi	200795|Chloroflexi	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
EH1_k127_4017422_22	1380393.JHVP01000015_gene4215	9.531e-21	104.0	COG2141@1|root,COG2141@2|Bacteria,2IEM9@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
EH1_k127_4017422_10	1041930.Mtc_0642	5.135e-50	188.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,2N9QW@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
EH1_k127_4017422_14	632335.Calkr_2642	2.526e-39	155.0	COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,25E4K@186801|Clostridia,42IGI@68295|Thermoanaerobacterales	186801|Clostridia	L	FES	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4,SfsA
EH1_k127_4017422_15	1365176.N186_09045	5.957e-39	160.0	COG2820@1|root,arCOG01324@2157|Archaea,2XPX2@28889|Crenarchaeota	1365176.N186_09045|-	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	-
EH1_k127_4017422_28	1411123.JQNH01000001_gene3458	6.08e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
EH1_k127_4017422_12	1125863.JAFN01000001_gene82	3.626e-44	176.0	COG0500@1|root,COG0644@1|root,COG0644@2|Bacteria,COG2226@2|Bacteria,1MXQY@1224|Proteobacteria,42UR3@68525|delta/epsilon subdivisions,2WQQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
EH1_k127_4017422_7	1128421.JAGA01000001_gene2396	2.285e-60	222.0	COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
EH1_k127_4017422_21	946362.XP_004987796.1	4.131e-23	108.0	KOG0266@1|root,KOG0271@1|root,KOG0272@1|root,KOG0266@2759|Eukaryota,KOG0271@2759|Eukaryota,KOG0272@2759|Eukaryota,38B6D@33154|Opisthokonta	33154|Opisthokonta	D	thiol-dependent ubiquitin-specific protease activity	-	-	-	-	-	-	-	-	-	-	-	-	WD40
EH1_k127_4032002_3	410358.Mlab_1717	2.937e-11	77.0	arCOG02547@1|root,arCOG02547@2157|Archaea	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5
EH1_k127_4032002_1	1041930.Mtc_0083	2.252e-49	185.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota,2NAR1@224756|Methanomicrobia	224756|Methanomicrobia	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
EH1_k127_4032002_0	1089553.Tph_c04360	5.096e-100	343.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,42EZ2@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
EH1_k127_4032002_2	351160.LRC325	2.724e-28	124.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	ABC_cobalt,Oxidored_molyb
EH1_k127_4046327_2	47839.CCAU010000011_gene5282	1.125e-43	167.0	COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,23AVQ@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH1_k127_4046327_1	439481.Aboo_1255	2.187e-64	245.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,3F353@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_4046327_0	439481.Aboo_1538	2.203e-87	301.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,3F2G6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmm4	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
EH1_k127_4151090_2	1231241.Mc24_08704	1.375e-10	61.0	COG2406@1|root,COG2406@2|Bacteria	2|Bacteria	S	Ferritin, Dps family protein	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
EH1_k127_4151090_1	1220534.B655_0700	3.174e-23	106.0	COG0735@1|root,arCOG01868@2157|Archaea,2Y1GV@28890|Euryarchaeota	28890|Euryarchaeota	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
EH1_k127_4151090_0	933262.AXAM01000010_gene1355	2.356e-109	375.0	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,1NGS5@1224|Proteobacteria,42S03@68525|delta/epsilon subdivisions,2WNW5@28221|Deltaproteobacteria,2MQ1F@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
EH1_k127_4217834_3	243090.RB6881	0.0005155	53.0	COG4591@1|root,COG4591@2|Bacteria,2IY15@203682|Planctomycetes	203682|Planctomycetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
EH1_k127_4217834_1	485913.Krac_5614	1.256e-06	62.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH1_k127_4217834_0	1219084.AP014508_gene646	1.634e-66	234.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_4217834_2	5722.XP_001315095.1	0.0002038	53.0	KOG0094@1|root,KOG0094@2759|Eukaryota	2759|Eukaryota	S	retrograde vesicle-mediated transport, Golgi to ER	-	-	-	ko:K07890,ko:K07893	-	-	-	-	ko00000,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_4245392_1	1227497.C491_14972	4.869e-35	144.0	COG0596@1|root,COG1893@1|root,arCOG01648@2157|Archaea,arCOG04139@2157|Archaea,2XVV6@28890|Euryarchaeota,23SZ9@183963|Halobacteria	183963|Halobacteria	H	Alpha beta fold family hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,ApbA
EH1_k127_4245392_0	439481.Aboo_0407	1.344e-85	304.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,3F35N@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_4245392_2	391009.Tmel_1189	3.9e-34	136.0	COG0601@1|root,COG0601@2|Bacteria,2GBYF@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH1_k127_4273195_4	368408.Tpen_0611	5.784e-75	260.0	COG1171@1|root,arCOG01431@2157|Archaea,2XPZF@28889|Crenarchaeota	28889|Crenarchaeota	E	Threonine dehydratase	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
EH1_k127_4273195_6	368408.Tpen_1831	1.266e-62	232.0	COG2211@1|root,arCOG00146@2157|Archaea,2XSCD@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
EH1_k127_4273195_13	883077.HMPREF9241_00667	1.824e-19	103.0	COG1073@1|root,COG1073@2|Bacteria,2IA0Y@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4,Peptidase_S15,Peptidase_S9
EH1_k127_4273195_2	1047013.AQSP01000059_gene2098	2.572e-114	376.0	COG0451@1|root,COG0451@2|Bacteria,2NQD6@2323|unclassified Bacteria	2|Bacteria	GM	RmlD substrate binding domain	ltd	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase
EH1_k127_4273195_12	1121896.JMLU01000004_gene2696	1.689e-19	101.0	COG0475@1|root,COG0490@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,4NGF6@976|Bacteroidetes,1HXGN@117743|Flavobacteriia,2NS6E@237|Flavobacterium	976|Bacteroidetes	P	proton antiporter	nhaA	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C
EH1_k127_4273195_0	177439.DP1368	0.0	1105.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
EH1_k127_4273195_1	926569.ANT_04650	3.866e-215	678.0	COG0031@1|root,COG0031@2|Bacteria,2G8GE@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
EH1_k127_4273195_5	568706.BN118_1474	3.01e-67	247.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2W07P@28216|Betaproteobacteria,3T6K8@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
EH1_k127_4273195_14	1504822.CCNO01000015_gene704	0.0001398	49.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2
EH1_k127_4273195_9	391625.PPSIR1_02216	9.994e-37	144.0	COG1611@1|root,COG1611@2|Bacteria,1RJ91@1224|Proteobacteria,42TR7@68525|delta/epsilon subdivisions,2WQUE@28221|Deltaproteobacteria,2Z1AI@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM conserved	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A,Lysine_decarbox
EH1_k127_4273195_8	7230.FBpp0167949	4.649e-44	171.0	COG0639@1|root,KOG0374@2759|Eukaryota,38BV2@33154|Opisthokonta,3B9MQ@33208|Metazoa,3CRW5@33213|Bilateria,41VYT@6656|Arthropoda,3SJ1J@50557|Insecta,44Y2G@7147|Diptera,45P46@7214|Drosophilidae	33208|Metazoa	T	serine threonine-protein phosphatase	-	GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.16	ko:K06269	ko03015,ko04022,ko04024,ko04113,ko04114,ko04218,ko04261,ko04270,ko04390,ko04510,ko04611,ko04720,ko04728,ko04750,ko04810,ko04910,ko04921,ko04931,ko05031,ko05034,ko05168,ko05205,map03015,map04022,map04024,map04113,map04114,map04218,map04261,map04270,map04390,map04510,map04611,map04720,map04728,map04750,map04810,map04910,map04921,map04931,map05031,map05034,map05168,map05205	-	-	-	ko00000,ko00001,ko01000,ko01009,ko03019,ko03021,ko03041	-	-	-	Metallophos,STPPase_N
EH1_k127_4273195_3	269797.Mbar_A1412	1.718e-94	322.0	COG2006@1|root,arCOG02447@2157|Archaea,2Y2ES@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
EH1_k127_4273195_7	1227349.C170_23935	8.997e-47	180.0	COG0382@1|root,COG0382@2|Bacteria,1TRTB@1239|Firmicutes,4HEED@91061|Bacilli,26QWA@186822|Paenibacillaceae	91061|Bacilli	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
EH1_k127_4273195_11	351160.RCIX2096	1.101e-28	124.0	COG0613@1|root,arCOG00302@2157|Archaea,2XT0K@28890|Euryarchaeota,2NAUQ@224756|Methanomicrobia	224756|Methanomicrobia	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
EH1_k127_4273195_10	502025.Hoch_6876	6.741e-35	146.0	COG0392@1|root,COG0392@2|Bacteria,1R4IS@1224|Proteobacteria,42WRK@68525|delta/epsilon subdivisions,2WSAB@28221|Deltaproteobacteria,2Z0VY@29|Myxococcales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
EH1_k127_4279917_17	192952.MM_1387	1.543e-31	129.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
EH1_k127_4279917_26	529709.PYCH_13090	1.788e-05	55.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
EH1_k127_4279917_25	456442.Mboo_1535	5.012e-08	58.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
EH1_k127_4279917_4	634498.mru_0456	5.058e-112	375.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
EH1_k127_4279917_5	626939.HMPREF9443_01527	3.858e-90	315.0	COG1032@1|root,COG1032@2|Bacteria,1TQJT@1239|Firmicutes,4H23J@909932|Negativicutes	909932|Negativicutes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH1_k127_4279917_20	70601.3258028	1.083e-15	82.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
EH1_k127_4279917_1	70601.3258418	6.55e-199	629.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
EH1_k127_4279917_12	511051.CSE_03210	1.261e-52	191.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	-	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
EH1_k127_4279917_0	529709.PYCH_15740	4.62e-233	735.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3
EH1_k127_4279917_22	579137.Metvu_1609	8.182e-13	74.0	COG1436@1|root,arCOG04102@2157|Archaea,2XZBY@28890|Euryarchaeota,23R66@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
EH1_k127_4279917_13	368408.Tpen_1158	9.698e-48	175.0	COG1781@1|root,arCOG04229@2157|Archaea,2XQJR@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
EH1_k127_4279917_2	342949.PNA2_0288	8.531e-151	490.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
EH1_k127_4279917_28	426368.MmarC7_0171	4.71e-05	53.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,23QED@183939|Methanococci	183939|Methanococci	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
EH1_k127_4279917_6	186497.PF1763	1.621e-89	308.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,242M3@183968|Thermococci	183968|Thermococci	S	gtp1 obg	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
EH1_k127_4279917_14	224719.Abm4_1341	5.58e-45	172.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23NM0@183925|Methanobacteria	183925|Methanobacteria	J	TIGRFAM RNA methyltransferase, TrmH	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
EH1_k127_4279917_15	399550.Smar_0629	1.921e-42	161.0	COG0197@1|root,arCOG04113@2157|Archaea,2XQ8E@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
EH1_k127_4279917_7	386456.JQKN01000001_gene1642	1.427e-83	288.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
EH1_k127_4279917_23	7668.SPU_027892-tr	5.467e-12	70.0	COG2451@1|root,KOG0887@2759|Eukaryota,3A60A@33154|Opisthokonta,3BQ9G@33208|Metazoa,3D7CG@33213|Bilateria	33208|Metazoa	J	structural constituent of ribosome	RPL35A	GO:0000184,GO:0000956,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006412,GO:0006413,GO:0006518,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0015031,GO:0015833,GO:0015934,GO:0016070,GO:0016071,GO:0016072,GO:0019222,GO:0019439,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0033036,GO:0033365,GO:0034470,GO:0034613,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0042254,GO:0042273,GO:0042886,GO:0043021,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045047,GO:0045184,GO:0046483,GO:0046700,GO:0046907,GO:0048519,GO:0050789,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060255,GO:0065007,GO:0070727,GO:0070972,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1990904	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
EH1_k127_4279917_27	339860.Msp_0396	1.973e-05	54.0	arCOG06453@1|root,arCOG06453@2157|Archaea,2XZAX@28890|Euryarchaeota,23P5V@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4279917_11	264732.Moth_0446	1.506e-64	233.0	COG1856@1|root,COG1856@2|Bacteria,1V23U@1239|Firmicutes,24E3M@186801|Clostridia,42GSP@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
EH1_k127_4279917_3	1184251.TCELL_0067	7.147e-114	384.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
EH1_k127_4279917_9	1183377.Py04_1719	2.534e-71	251.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,242R3@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
EH1_k127_4279917_8	573063.Metin_0747	7.989e-81	276.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,23Q8C@183939|Methanococci	183939|Methanococci	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
EH1_k127_4279917_18	1042375.AFPL01000026_gene3542	2.25e-30	123.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
EH1_k127_4279917_16	1330700.JQNC01000003_gene522	1.948e-36	145.0	COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
EH1_k127_4279917_24	877455.Metbo_0652	4.748e-09	63.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
EH1_k127_4279917_21	109760.SPPG_05221T0	1.102e-13	75.0	KOG4115@1|root,KOG4115@2759|Eukaryota,3A3F9@33154|Opisthokonta,3P6RS@4751|Fungi	4751|Fungi	DN	Dynein light chain	-	-	-	ko:K10419	-	-	-	-	ko00000,ko04131,ko04812	-	-	-	Robl_LC7
EH1_k127_4279917_19	7668.SPU_005782-tr	1.163e-27	129.0	COG1100@1|root,KOG0395@2759|Eukaryota,39D71@33154|Opisthokonta,3BMYE@33208|Metazoa,3D5GM@33213|Bilateria	33208|Metazoa	S	Sec23/Sec24 zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	Ras,zf-Sec23_Sec24
EH1_k127_4279917_10	272844.PAB2109	6.568e-66	237.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
EH1_k127_4309241_1	477974.Daud_1208	8.181e-31	125.0	COG1239@1|root,COG1239@2|Bacteria,1UHYK@1239|Firmicutes,24BJ0@186801|Clostridia,2609Y@186807|Peptococcaceae	186801|Clostridia	H	PFAM magnesium chelatase	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Mg_chelatase,VWA_2
EH1_k127_4309241_0	1379698.RBG1_1C00001G1186	5.179e-107	359.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH1_k127_4315716_6	333138.LQ50_10615	5.676e-66	237.0	COG2223@1|root,COG2223@2|Bacteria,1TPR9@1239|Firmicutes,4HB93@91061|Bacilli,1ZAP4@1386|Bacillus	91061|Bacilli	P	Major facilitator superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
EH1_k127_4315716_0	1125863.JAFN01000001_gene2044	1.362e-188	607.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
EH1_k127_4315716_11	1128421.JAGA01000003_gene2815	1.121e-48	186.0	COG1082@1|root,COG1082@2|Bacteria,2NRRT@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH1_k127_4315716_10	1185876.BN8_04452	2.086e-51	187.0	COG0652@1|root,COG0652@2|Bacteria,4NKQ7@976|Bacteroidetes,47P72@768503|Cytophagia	976|Bacteroidetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
EH1_k127_4315716_9	868131.MSWAN_2078	1.003e-53	208.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
EH1_k127_4315716_12	224325.AF_2051	3.29e-39	153.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,245SF@183980|Archaeoglobi	183980|Archaeoglobi	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
EH1_k127_4315716_15	1183377.Py04_1673	8.595e-18	85.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,244GS@183968|Thermococci	183968|Thermococci	J	H ACA RNA-protein complex	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
EH1_k127_4315716_17	1236689.MMALV_03090	1.035e-10	67.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68Y@28890|Euryarchaeota,3F2VA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
EH1_k127_4315716_7	243231.GSU1686	1.218e-58	207.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,43U1G@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM CMP dCMP deaminase zinc-binding	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
EH1_k127_4315716_2	342949.PNA2_1365	6.946e-97	327.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
EH1_k127_4315716_5	1151117.AJLF01000003_gene630	2.682e-66	234.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
EH1_k127_4315716_1	251229.Chro_1236	4.763e-169	558.0	COG1501@1|root,COG1501@2|Bacteria,1GJ64@1117|Cyanobacteria,3VMTY@52604|Pleurocapsales	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
EH1_k127_4315716_16	234267.Acid_7434	2.758e-12	75.0	2DPU7@1|root,333E3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4315716_4	868131.MSWAN_0451	1.177e-78	273.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,23PC2@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
EH1_k127_4315716_18	6326.BUX.s00579.383	1.489e-06	54.0	COG5131@1|root,KOG4146@2759|Eukaryota,3A8YT@33154|Opisthokonta,3BRH6@33208|Metazoa,3D863@33213|Bilateria,40EYU@6231|Nematoda,1KXB8@119089|Chromadorea	33208|Metazoa	O	Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates	URM1	GO:0001932,GO:0001933,GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010467,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0016070,GO:0019220,GO:0019222,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032872,GO:0032873,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042325,GO:0042326,GO:0043170,GO:0043408,GO:0043409,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045936,GO:0046328,GO:0046329,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070302,GO:0070303,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:1901360,GO:1902531,GO:1902532	-	ko:K12161	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016,ko04121	-	-	-	Urm1
EH1_k127_4315716_13	243232.MJ_0536	4.925e-35	139.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
EH1_k127_4315716_3	1343739.PAP_05655	8.761e-92	309.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2436C@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit beta	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
EH1_k127_4315716_14	326427.Cagg_1682	6.445e-24	104.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_23570	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_34
EH1_k127_4315716_8	768710.DesyoDRAFT_1409	2.27e-58	211.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,261DY@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K16907	ko02010,map02010	M00224,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_4318892_0	1459636.NTE_01385	2.364e-41	163.0	COG1650@1|root,arCOG01616@2157|Archaea,41SM3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
EH1_k127_4335636_0	411467.BACCAP_01345	2.312e-57	212.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
EH1_k127_4335636_1	1118235.CAJH01000031_gene2094	1.529e-14	86.0	COG0477@1|root,COG2814@2|Bacteria,1MVSC@1224|Proteobacteria,1RY0N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
EH1_k127_4335636_2	1196031.ALEG01000041_gene2570	3.718e-08	59.0	COG4126@1|root,COG4126@2|Bacteria,1V0N4@1239|Firmicutes,4HPMW@91061|Bacilli,1ZR4N@1386|Bacillus	91061|Bacilli	E	Hydantoin racemase	-	-	5.1.99.3	ko:K16841	ko00230,ko01120,map00230,map01120	-	R03925	RC01027	ko00000,ko00001,ko01000	-	-	-	-
EH1_k127_43378_3	186497.PF0494	1.622e-09	61.0	COG0550@1|root,COG1372@1|root,arCOG01527@2157|Archaea,arCOG03151@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
EH1_k127_43378_0	1120950.KB892780_gene389	1.351e-127	424.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DN4J@85009|Propionibacteriales	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
EH1_k127_43378_2	386456.JQKN01000022_gene65	1.911e-37	158.0	arCOG02499@1|root,arCOG02545@1|root,arCOG02552@1|root,arCOG02499@2157|Archaea,arCOG02545@2157|Archaea,arCOG02552@2157|Archaea	2157|Archaea	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,NosD,PKD
EH1_k127_4352810_4	1365176.N186_05070	1.725e-14	77.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
EH1_k127_4352810_2	444158.MmarC6_1459	2.439e-43	163.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
EH1_k127_4352810_1	192952.MM_0870	2.463e-135	441.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
EH1_k127_4352810_0	877455.Metbo_1378	5.775e-141	455.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
EH1_k127_4352810_3	1151117.AJLF01000001_gene744	1.514e-39	165.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,243IC@183968|Thermococci	183968|Thermococci	E	Glutamine amidotransferase domain	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
EH1_k127_4360965_5	224325.AF_1264	1.451e-05	55.0	COG0640@1|root,arCOG00734@2157|Archaea,2XXHJ@28890|Euryarchaeota	28890|Euryarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
EH1_k127_4360965_0	1128421.JAGA01000002_gene776	6.409e-81	281.0	COG3342@1|root,COG3342@2|Bacteria,2NP87@2323|unclassified Bacteria	2|Bacteria	S	Family of unknown function (DUF1028)	fimA	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
EH1_k127_4360965_4	477974.Daud_0311	6.301e-07	60.0	COG1695@1|root,COG1695@2|Bacteria,1VAP9@1239|Firmicutes,24QGK@186801|Clostridia,262MQ@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
EH1_k127_4360965_3	1469948.JPNB01000002_gene3547	8.957e-13	71.0	2E5YB@1|root,330N1@2|Bacteria,1VEVQ@1239|Firmicutes,24RVC@186801|Clostridia,36N0A@31979|Clostridiaceae	186801|Clostridia	S	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
EH1_k127_4360965_1	717231.Flexsi_0766	1.641e-47	193.0	COG0642@1|root,COG0715@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG0715@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,2GF9Q@200930|Deferribacteres	200930|Deferribacteres	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_4,Response_reg
EH1_k127_4360965_2	368407.Memar_2344	1.186e-14	88.0	arCOG02343@1|root,arCOG06516@1|root,arCOG02343@2157|Archaea,arCOG06516@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9
EH1_k127_4360965_6	1242864.D187_001422	0.0008554	47.0	COG2881@1|root,COG2881@2|Bacteria,1P822@1224|Proteobacteria,432BA@68525|delta/epsilon subdivisions,2WXRV@28221|Deltaproteobacteria,2Z17R@29|Myxococcales	28221|Deltaproteobacteria	S	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
EH1_k127_4361831_5	673860.AciM339_0281	8.17e-05	47.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,3F2FI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	B3/4 domain	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
EH1_k127_4361831_3	946362.XP_004994767.1	1.281e-28	123.0	COG1100@1|root,KOG0098@2759|Eukaryota,38D6D@33154|Opisthokonta	33154|Opisthokonta	U	GTPase activity	RAB2A	GO:0000139,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006464,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0006996,GO:0007030,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0023052,GO:0031090,GO:0031984,GO:0032482,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0034613,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042175,GO:0042886,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0048193,GO:0048471,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0065007,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0097159,GO:0097367,GO:0097458,GO:0098588,GO:0098791,GO:0098827,GO:1901265,GO:1901363,GO:1901564	-	ko:K07877	ko04152,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras,Roc
EH1_k127_4361831_4	1229909.NSED_07225	1.358e-14	78.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH1_k127_4361831_2	181119.XP_005531554.1	2.591e-29	124.0	KOG0080@1|root,KOG0080@2759|Eukaryota,3AHG8@33154|Opisthokonta,3BX48@33208|Metazoa,3DDHH@33213|Bilateria,48IIW@7711|Chordata,49F2F@7742|Vertebrata,4GI94@8782|Aves	33208|Metazoa	U	Ras-related protein Rab-18-B-like	-	-	-	ko:K07910	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Ras
EH1_k127_4361831_0	941824.TCEL_02067	5.089e-130	428.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,36EP1@31979|Clostridiaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
EH1_k127_4361831_1	453591.Igni_1108	7.451e-88	306.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
EH1_k127_436906_0	572547.Amico_1777	7.718e-46	184.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_4394315_0	716544.wcw_1291	3.472e-251	835.0	COG0178@1|root,COG0178@2|Bacteria,2JFSD@204428|Chlamydiae	204428|Chlamydiae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
EH1_k127_4394315_5	1541960.KQ78_01444	4.875e-43	170.0	2E6H4@1|root,3314B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4394315_7	1392491.JIAE01000001_gene1130	1.705e-05	54.0	COG0454@1|root,COG0454@2|Bacteria,1V1JN@1239|Firmicutes,24C53@186801|Clostridia,3WIWN@541000|Ruminococcaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
EH1_k127_4394315_2	1047013.AQSP01000144_gene915	4.624e-81	278.0	COG0492@1|root,COG0822@1|root,COG0492@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_oxidored,FeS_assembly_P,NifU_N,Pyr_redox_2,cNMP_binding
EH1_k127_4394315_1	1047013.AQSP01000144_gene916	2.525e-169	539.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
EH1_k127_4394315_4	1047013.AQSP01000144_gene917	3.99e-51	185.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,DrsE_2
EH1_k127_4394315_6	1047013.AQSP01000144_gene918	2.484e-26	109.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
EH1_k127_4394315_3	264732.Moth_2511	1.057e-53	199.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,42FCT@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase,QueC
EH1_k127_4395837_0	517418.Ctha_0501	6.311e-56	198.0	COG0229@1|root,COG0229@2|Bacteria,1FDWG@1090|Chlorobi	1090|Chlorobi	C	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
EH1_k127_4395837_3	768679.TTX_0226	5.318e-07	54.0	arCOG03714@1|root,arCOG03714@2157|Archaea	2157|Archaea	F	ATP cone domain	nrdD	-	1.1.98.6,1.17.4.1	ko:K00525,ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,NRDD,Ribonuc_red_lgC,Ribonuc_red_lgN
EH1_k127_4395837_2	1410665.JNKR01000001_gene561	4.018e-23	108.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,4H3ZP@909932|Negativicutes	909932|Negativicutes	S	Serine aminopeptidase, S33	est	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
EH1_k127_4395837_1	696281.Desru_2615	1.681e-46	175.0	COG0778@1|root,COG0778@2|Bacteria,1UZC3@1239|Firmicutes,24BKG@186801|Clostridia,264TH@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
EH1_k127_4410569_1	1305737.JAFX01000001_gene373	5.195e-51	185.0	COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,47XSR@768503|Cytophagia	976|Bacteroidetes	O	AhpC/TSA antioxidant enzyme	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
EH1_k127_4410569_2	518766.Rmar_1485	1.382e-44	166.0	COG1225@1|root,COG1225@2|Bacteria,4NNGK@976|Bacteroidetes,1FK3Q@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	AhpC/TSA antioxidant enzyme	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
EH1_k127_4410569_0	909663.KI867150_gene284	8.704e-164	526.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MQ89@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
EH1_k127_4420351_1	1128421.JAGA01000002_gene1392	5.563e-43	173.0	COG4552@1|root,COG4552@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_9
EH1_k127_4420351_0	35841.BT1A1_1716	5.858e-53	196.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,1ZB50@1386|Bacillus	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
EH1_k127_4420351_3	573064.Mefer_1539	1.042e-19	99.0	COG4088@1|root,arCOG01041@2157|Archaea,2XWNQ@28890|Euryarchaeota,23QTG@183939|Methanococci	183939|Methanococci	F	PFAM Chromatin associated protein KTI12	pstK	-	2.7.1.164	ko:K10837	ko00450,ko00970,map00450,map00970	-	R08223	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	KTI12
EH1_k127_4420351_2	1296415.JACC01000054_gene2917	1.826e-42	171.0	COG4990@1|root,COG4990@2|Bacteria,4NFZX@976|Bacteroidetes,1HXZ6@117743|Flavobacteriia,2YIW7@290174|Aquimarina	976|Bacteroidetes	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
EH1_k127_4420351_4	658659.HMPREF0983_02094	0.0005274	48.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,3VPEV@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
EH1_k127_4442007_1	933801.Ahos_0100	2.257e-13	83.0	arCOG03462@1|root,arCOG03462@2157|Archaea,2XR2E@28889|Crenarchaeota	28889|Crenarchaeota	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
EH1_k127_4442007_2	1489678.RDMS_12775	2.623e-08	64.0	COG1715@1|root,COG1715@2|Bacteria,1WMPN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat
EH1_k127_4442007_0	292459.STH69	5.794e-104	370.0	COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,24XGP@186801|Clostridia	186801|Clostridia	C	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
EH1_k127_4459193_3	933801.Ahos_0634	4.025e-09	60.0	COG1552@1|root,arCOG04049@2157|Archaea,2XRHJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
EH1_k127_4459193_1	1220534.B655_0494	4.373e-101	336.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota,23NJ9@183925|Methanobacteria	183925|Methanobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
EH1_k127_4459193_0	926569.ANT_20580	4.153e-101	341.0	COG0045@1|root,COG0045@2|Bacteria,2G68A@200795|Chloroflexi	200795|Chloroflexi	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
EH1_k127_4459193_2	1459636.NTE_02733	3.057e-13	83.0	COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
EH1_k127_4461796_2	1151292.QEW_3681	7.302e-71	258.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,25TG8@186804|Peptostreptococcaceae	186801|Clostridia	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
EH1_k127_4461796_4	335543.Sfum_2018	2.912e-39	158.0	COG0491@1|root,COG0491@2|Bacteria,1MW35@1224|Proteobacteria,42RFB@68525|delta/epsilon subdivisions,2WNGT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_4461796_1	555088.DealDRAFT_3077	1.446e-71	253.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42JIV@68298|Syntrophomonadaceae	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
EH1_k127_4461796_6	384616.Pisl_1438	2.297e-10	66.0	COG1250@1|root,COG1545@1|root,arCOG00249@2157|Archaea,arCOG01283@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
EH1_k127_4461796_0	706587.Desti_2452	7.738e-102	344.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
EH1_k127_4461796_3	273068.TTE0544	5.575e-57	208.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
EH1_k127_4461796_5	224325.AF_2273	3.026e-26	113.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,245SW@183980|Archaeoglobi	28890|Euryarchaeota	I	Belongs to the enoyl-CoA hydratase isomerase family	hbd2	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
EH1_k127_4469288_0	3885.XP_007143732.1	1.532e-61	222.0	COG0003@1|root,KOG2825@2759|Eukaryota,37PA4@33090|Viridiplantae,3G7Q7@35493|Streptophyta,4JF73@91835|fabids	35493|Streptophyta	P	Arsenical pump-driving	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
EH1_k127_4469288_1	589924.Ferp_1929	2.092e-41	164.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
EH1_k127_4481204_0	497321.C664_13679	8.427e-24	117.0	28IZ9@1|root,2Z8WS@2|Bacteria,1NRVI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_3
EH1_k127_4481204_1	1157490.EL26_24230	3.879e-21	108.0	COG0846@1|root,COG0846@2|Bacteria,1V84H@1239|Firmicutes	1239|Firmicutes	K	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
EH1_k127_4484173_2	1382304.JNIL01000001_gene1376	8.231e-62	221.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4H9W6@91061|Bacilli	91061|Bacilli	G	Belongs to the FGGY kinase family	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
EH1_k127_4484173_6	1219084.AP014508_gene679	7.773e-42	171.0	COG3875@1|root,COG3875@2|Bacteria,2GD6T@200918|Thermotogae	200918|Thermotogae	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
EH1_k127_4484173_8	797210.Halxa_1830	8.301e-13	79.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,23THJ@183963|Halobacteria	183963|Halobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
EH1_k127_4484173_9	1198449.ACAM_1459	2.4e-10	69.0	COG0636@1|root,arCOG02455@2157|Archaea,2XR87@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase proteolipid subunit family	atpP	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
EH1_k127_4484173_11	1183377.Py04_0330	6.266e-07	59.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,243A6@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
EH1_k127_4484173_5	523845.AQXV01000049_gene944	3.633e-44	184.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,23Q54@183939|Methanococci	183939|Methanococci	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
EH1_k127_4484173_3	374847.Kcr_1358	6.79e-54	198.0	COG2519@1|root,arCOG00978@2157|Archaea	2157|Archaea	J	tRNA methyltransferase complex GCD14 subunit	trmI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0031515,GO:0032991,GO:0034708,GO:0043527,GO:0044424,GO:0044444,GO:0044464,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
EH1_k127_4484173_4	1094980.Mpsy_1920	1.161e-50	204.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota,2N9G3@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
EH1_k127_4484173_10	1365176.N186_03930	2.055e-08	60.0	arCOG04275@1|root,arCOG04275@2157|Archaea,2XR2U@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4484173_1	1459636.NTE_00156	1.503e-86	293.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	2157|Archaea	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
EH1_k127_4484173_0	1459636.NTE_00155	3.584e-95	323.0	COG1131@1|root,arCOG00194@2157|Archaea,41TB9@651137|Thaumarchaeota	651137|Thaumarchaeota	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH1_k127_4484173_7	1131266.ARWQ01000018_gene777	8.634e-42	165.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
EH1_k127_450766_1	368408.Tpen_1350	3.082e-63	223.0	COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota	28889|Crenarchaeota	E	carboxypeptidase activity	-	-	-	ko:K12941,ko:K13048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
EH1_k127_450766_0	760192.Halhy_0173	2.124e-262	839.0	COG0160@1|root,COG0739@1|root,COG2334@1|root,COG0160@2|Bacteria,COG0739@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1IWK9@117747|Sphingobacteriia	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
EH1_k127_4521893_1	1150399.AQYK01000001_gene1767	1.265e-14	78.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FKZR@85023|Microbacteriaceae	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD2	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
EH1_k127_4521893_0	1123360.thalar_00287	3.076e-39	162.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,2TVK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,FAD_oxidored,Lycopene_cycl,Trp_halogenase
EH1_k127_4530369_4	415426.Hbut_0047	1.749e-23	106.0	COG1032@1|root,arCOG01356@2157|Archaea,2XPY0@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
EH1_k127_4530369_3	573063.Metin_0629	4.869e-29	119.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23R03@183939|Methanococci	183939|Methanococci	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
EH1_k127_4530369_0	644281.MFS40622_1394	1.821e-107	357.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23QG1@183939|Methanococci	183939|Methanococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	Intein_splicing,TFIIB,TF_Zn_Ribbon
EH1_k127_4530369_2	523850.TON_0362	9.297e-62	224.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
EH1_k127_4530369_5	1122244.AUGF01000013_gene452	7.677e-15	79.0	COG2018@1|root,COG2018@2|Bacteria,1RIQC@1224|Proteobacteria,1S65Z@1236|Gammaproteobacteria,3NRCW@468|Moraxellaceae	1236|Gammaproteobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
EH1_k127_4530369_1	246969.TAM4_2030	5.567e-72	251.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
EH1_k127_4530369_6	1122176.KB903609_gene5211	1.097e-10	70.0	COG2020@1|root,COG2020@2|Bacteria,4NXS4@976|Bacteroidetes,1IYCG@117747|Sphingobacteriia	976|Bacteroidetes	O	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
EH1_k127_4561685_0	1167006.UWK_00583	8.249e-71	251.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
EH1_k127_4561685_1	572479.Hprae_0499	2.607e-69	246.0	COG2407@1|root,COG2407@2|Bacteria,1TPEK@1239|Firmicutes,24BY2@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4613110_4	906968.Trebr_0011	0.0003153	51.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,2J58N@203691|Spirochaetes	203691|Spirochaetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
EH1_k127_4613110_3	1343739.PAP_02640	0.0003153	51.0	arCOG07677@1|root,arCOG07677@2157|Archaea,2XWVM@28890|Euryarchaeota,244MD@183968|Thermococci	183968|Thermococci	S	Possible catecholamine-binding domain present in a variety of eukaryotic proteins.	-	-	-	-	-	-	-	-	-	-	-	-	DOMON
EH1_k127_4613110_1	671065.MetMK1DRAFT_00030030	3.654e-37	153.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
EH1_k127_4613110_0	436308.Nmar_1407	1.218e-106	356.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
EH1_k127_4613110_2	1229909.NSED_07735	1.711e-28	121.0	COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
EH1_k127_466166_0	1210908.HSB1_42480	5.478e-87	328.0	COG2304@1|root,arCOG07561@1|root,arCOG02902@2157|Archaea,arCOG07561@2157|Archaea,2XUQK@28890|Euryarchaeota,23TQB@183963|Halobacteria	183963|Halobacteria	K	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_466166_2	1229276.DI53_1347	2.763e-37	153.0	COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,1IRV1@117747|Sphingobacteriia	976|Bacteroidetes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_466166_3	523850.TON_1355	5.709e-37	163.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,24359@183968|Thermococci	183968|Thermococci	O	Serine protease with a broad substrate specificity	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
EH1_k127_466166_1	1122138.AQUZ01000036_gene5471	6.259e-38	162.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4DU0R@85009|Propionibacteriales	201174|Actinobacteria	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH1_k127_4668180_5	596152.DesU5LDRAFT_2681	9.521e-12	66.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4668180_7	1121447.JONL01000018_gene3730	0.0001222	46.0	2AIDT@1|root,318V7@2|Bacteria,1Q10N@1224|Proteobacteria,43ETZ@68525|delta/epsilon subdivisions,2X1RT@28221|Deltaproteobacteria,2MFIZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4668180_0	1459636.NTE_00443	1.137e-131	453.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
EH1_k127_4668180_3	1056495.Calag_0282	6.192e-13	74.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	HTH_45
EH1_k127_4668180_2	1089548.KI783301_gene959	2.344e-35	143.0	COG1670@1|root,COG1670@2|Bacteria,1V3W1@1239|Firmicutes,4HH6A@91061|Bacilli,3WETK@539002|Bacillales incertae sedis	91061|Bacilli	J	Acetyltransferase (GNAT) domain	speG	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
EH1_k127_4668180_4	945713.IALB_3030	1.737e-12	74.0	COG3439@1|root,COG3439@2|Bacteria	2|Bacteria	D	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
EH1_k127_4668180_1	1305836.AXVE01000001_gene2681	2.751e-36	147.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4IQCJ@91061|Bacilli	91061|Bacilli	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH1_k127_4668180_8	865937.Gilli_2897	0.0002115	47.0	COG1764@1|root,COG1764@2|Bacteria,4PK2K@976|Bacteroidetes,1IGG0@117743|Flavobacteriia,2P7S9@244698|Gillisia	976|Bacteroidetes	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
EH1_k127_4670423_0	1121428.DESHY_110526___1	6.055e-278	874.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
EH1_k127_4670423_1	574087.Acear_0289	8.465e-152	500.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WAG5@53433|Halanaerobiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
EH1_k127_4670423_8	374847.Kcr_0871	8.618e-14	75.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_11,HTH_24
EH1_k127_4670423_2	374847.Kcr_0873	1.705e-122	415.0	COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
EH1_k127_4670423_10	1089553.Tph_c15740	6.614e-09	59.0	COG4231@1|root,COG4231@2|Bacteria,1UN0W@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH1_k127_4670423_6	679926.Mpet_0168	1.713e-34	151.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
EH1_k127_4670423_9	868131.MSWAN_0532	6.084e-11	70.0	COG0457@1|root,arCOG03038@2157|Archaea,2Y021@28890|Euryarchaeota	28890|Euryarchaeota	S	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
EH1_k127_4670423_7	1286106.MPL1_01503	4.903e-25	109.0	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,462VF@72273|Thiotrichales	72273|Thiotrichales	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
EH1_k127_4670423_5	246969.TAM4_929	8.12e-57	208.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,245B1@183968|Thermococci	183968|Thermococci	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
EH1_k127_4670423_3	368408.Tpen_0618	4.718e-80	277.0	COG0005@1|root,arCOG01327@2157|Archaea,2XPU0@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
EH1_k127_4670423_4	1042877.GQS_02055	1.328e-60	216.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,24312@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
EH1_k127_4726344_2	1380394.JADL01000002_gene1563	9.396e-07	57.0	COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,2TRTS@28211|Alphaproteobacteria,2JPRJ@204441|Rhodospirillales	204441|Rhodospirillales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
EH1_k127_4726344_0	342949.PNA2_1872	7.304e-112	379.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH1_k127_4726344_1	1183377.Py04_1039	1.087e-67	250.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH1_k127_4732627_7	1047013.AQSP01000131_gene1829	2.493e-14	86.0	COG3049@1|root,COG3049@2|Bacteria,2NQGK@2323|unclassified Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	AAT,CBAH
EH1_k127_4732627_5	1220534.B655_1160	1.973e-36	144.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
EH1_k127_4732627_10	1121090.KB894688_gene1660	9.931e-08	59.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,1ZC0T@1386|Bacillus	91061|Bacilli	T	Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like
EH1_k127_4732627_3	368408.Tpen_1831	1.046e-50	198.0	COG2211@1|root,arCOG00146@2157|Archaea,2XSCD@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
EH1_k127_4732627_8	742742.HMPREF9452_00349	1.018e-13	83.0	COG3594@1|root,COG3594@2|Bacteria,2I733@201174|Actinobacteria,4CXM4@84998|Coriobacteriia	84998|Coriobacteriia	G	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
EH1_k127_4732627_4	945713.IALB_3117	1.32e-40	153.0	2DTJ6@1|root,33KM6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4732627_0	469617.FUAG_02465	3.554e-198	628.0	COG2368@1|root,COG2368@2|Bacteria,379E7@32066|Fusobacteria	32066|Fusobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
EH1_k127_4732627_6	1111479.AXAR01000001_gene56	2.723e-23	102.0	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,4HNJA@91061|Bacilli,27AGD@186823|Alicyclobacillaceae	91061|Bacilli	S	Uncharacterized conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
EH1_k127_4732627_2	1499967.BAYZ01000137_gene110	6.944e-84	288.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
EH1_k127_4732627_1	572547.Amico_0493	2.681e-84	280.0	COG2406@1|root,COG2406@2|Bacteria,3TBV6@508458|Synergistetes	508458|Synergistetes	S	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
EH1_k127_4732819_1	1324957.K933_04771	1.102e-27	125.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23U8X@183963|Halobacteria	183963|Halobacteria	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa2	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	REPA_OB_2,tRNA_anti-codon
EH1_k127_4732819_0	529709.PYCH_16190	2.378e-308	983.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,24309@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
EH1_k127_4732819_2	391623.TERMP_00084	0.0002458	47.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2438A@183968|Thermococci	183968|Thermococci	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH1_k127_4762753_0	351160.RCIX51	2.344e-85	289.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_4762753_2	351160.RCIX50	7.801e-22	104.0	COG1277@1|root,arCOG02436@2157|Archaea	2157|Archaea	S	ABC-type transport system involved in multi-copper enzyme maturation, permease	nosY2	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
EH1_k127_4762753_1	391937.NA2_00900	1.127e-25	115.0	COG1920@1|root,COG1920@2|Bacteria,1RJPN@1224|Proteobacteria,2UAA7@28211|Alphaproteobacteria,43PJS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
EH1_k127_4762753_3	748449.Halha_0740	5.724e-05	46.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,3WA6M@53433|Halanaerobiales	186801|Clostridia	S	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
EH1_k127_4845737_2	1121430.JMLG01000002_gene1134	1.561e-52	188.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1V3TD@1239|Firmicutes,24I7A@186801|Clostridia,261TJ@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4845737_1	386456.JQKN01000001_gene2178	9.439e-53	196.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,23PF5@183925|Methanobacteria	183925|Methanobacteria	G	TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
EH1_k127_4845737_3	1183377.Py04_0985	5.616e-24	116.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
EH1_k127_4845737_0	644281.MFS40622_1394	1.115e-87	299.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23QG1@183939|Methanococci	183939|Methanococci	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	Intein_splicing,TFIIB,TF_Zn_Ribbon
EH1_k127_4845737_4	1408254.T458_02920	7.408e-13	75.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,26R9D@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
EH1_k127_4881387_2	171693.BN988_02129	1.074e-15	80.0	COG1402@1|root,COG1402@2|Bacteria,1TUPU@1239|Firmicutes,4IDQU@91061|Bacilli,23MT3@182709|Oceanobacillus	91061|Bacilli	S	Creatinine amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Creatininase
EH1_k127_4881387_1	1521187.JPIM01000014_gene1792	8.496e-35	144.0	COG2227@1|root,COG2227@2|Bacteria,2G97F@200795|Chloroflexi,376WF@32061|Chloroflexia	32061|Chloroflexia	H	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
EH1_k127_4881387_0	368408.Tpen_0613	7.188e-161	530.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
EH1_k127_4882141_2	118168.MC7420_6983	2.3e-12	74.0	29WN8@1|root,30I93@2|Bacteria,1GAIY@1117|Cyanobacteria	1117|Cyanobacteria	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
EH1_k127_4882141_1	573370.DMR_11120	2.578e-29	132.0	COG4191@1|root,COG4191@2|Bacteria,1NV35@1224|Proteobacteria,42ZJY@68525|delta/epsilon subdivisions,2WV44@28221|Deltaproteobacteria,2MH8B@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
EH1_k127_4882141_0	410358.Mlab_1687	1.187e-39	153.0	arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
EH1_k127_4898369_1	69014.TK0524	6.681e-23	98.0	COG1773@1|root,arCOG04391@2157|Archaea,2Y080@28890|Euryarchaeota,244NA@183968|Thermococci	183968|Thermococci	C	Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
EH1_k127_4898369_2	188626.HMPREF0321_1816	5.108e-10	73.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,1ZWBP@145357|Dermacoccaceae	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH1_k127_4898369_0	665571.STHERM_c16030	6.391e-82	279.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
EH1_k127_4919143_2	768679.TTX_0168	1.693e-12	72.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
EH1_k127_4919143_1	373903.Hore_10920	9.557e-15	81.0	COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia,3WAUH@53433|Halanaerobiales	186801|Clostridia	S	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
EH1_k127_4919143_0	192952.MM_1958	2.529e-27	119.0	COG0537@1|root,arCOG00419@2157|Archaea,2XXWC@28890|Euryarchaeota,2NBIU@224756|Methanomicrobia	224756|Methanomicrobia	F	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
EH1_k127_4919143_3	479433.Caci_5177	2.426e-08	66.0	COG5426@1|root,COG5426@2|Bacteria,2GKG4@201174|Actinobacteria	201174|Actinobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_4920128_6	865861.AZSU01000001_gene385	1.938e-10	66.0	COG0842@1|root,COG0842@2|Bacteria,1VI3K@1239|Firmicutes,24DXR@186801|Clostridia,36HU6@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
EH1_k127_4920128_4	1499689.CCNN01000004_gene101	2.281e-13	81.0	COG0842@1|root,COG0842@2|Bacteria,1VI3K@1239|Firmicutes,24DXR@186801|Clostridia,36HU6@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
EH1_k127_4920128_0	1033737.CAEV01000022_gene3286	1.409e-73	260.0	COG1131@1|root,COG1131@2|Bacteria,1UHTY@1239|Firmicutes,24JZH@186801|Clostridia,36UHX@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH1_k127_4920128_7	740709.A10D4_01557	1.941e-09	68.0	COG0697@1|root,COG0697@2|Bacteria,1R4G2@1224|Proteobacteria,1S08Y@1236|Gammaproteobacteria,2QFYR@267893|Idiomarinaceae	1236|Gammaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH1_k127_4920128_2	4555.Si002885m	1.28e-28	123.0	KOG0078@1|root,KOG0078@2759|Eukaryota,37N43@33090|Viridiplantae,3G7UH@35493|Streptophyta	35493|Streptophyta	U	Ras-related protein	-	-	-	ko:K07901	ko04144,ko04152,ko04530,ko04972,map04144,map04152,map04530,map04972	-	-	-	ko00000,ko00001,ko03036,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_4920128_1	1041930.Mtc_1660	1.118e-70	250.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
EH1_k127_4920128_3	1122216.AUHW01000036_gene2054	5.308e-16	88.0	COG2006@1|root,COG2768@1|root,COG2006@2|Bacteria,COG2768@2|Bacteria,1TRX2@1239|Firmicutes,4H3TS@909932|Negativicutes	909932|Negativicutes	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_6
EH1_k127_4920128_5	144197.XP_008274907.1	1.263e-10	71.0	COG4886@1|root,KOG0619@2759|Eukaryota,39RSF@33154|Opisthokonta,3BKMK@33208|Metazoa,3D43C@33213|Bilateria,48DAJ@7711|Chordata,48WHA@7742|Vertebrata,4A1C1@7898|Actinopterygii	33208|Metazoa	T	repeat transmembrane neuronal	-	-	-	-	-	-	-	-	-	-	-	-	LRR_8
EH1_k127_4920128_8	351160.RCIX850	0.0004317	43.0	COG2202@1|root,COG3920@1|root,arCOG02335@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS_9
EH1_k127_4923427_0	304371.MCP_2379	4.672e-28	119.0	COG0477@1|root,arCOG00130@2157|Archaea,2XVFS@28890|Euryarchaeota,2NAF6@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
EH1_k127_4923427_1	368408.Tpen_0889	6.987e-23	104.0	COG2150@1|root,arCOG02316@2157|Archaea	2157|Archaea	EH	regulator of amino acid metabolism, contains ACT domain	trpY	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	ACT
EH1_k127_4923427_2	268407.PWYN_02420	1.462e-11	73.0	COG1247@1|root,COG1247@2|Bacteria,1V56F@1239|Firmicutes,4HHFP@91061|Bacilli,26XVW@186822|Paenibacillaceae	91061|Bacilli	M	GCN5 family acetyltransferase	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
EH1_k127_4931151_4	690850.Desaf_0247	1.793e-07	57.0	COG0697@1|root,COG0697@2|Bacteria,1NCEQ@1224|Proteobacteria,43AZZ@68525|delta/epsilon subdivisions,2X6E2@28221|Deltaproteobacteria,2MH1V@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH1_k127_4931151_2	1121403.AUCV01000002_gene551	2.442e-39	159.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria,2MIE6@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH1_k127_4931151_3	743525.TSC_c03580	1.473e-22	102.0	COG3118@1|root,COG3118@2|Bacteria,1WK9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
EH1_k127_4931151_1	8090.ENSORLP00000012747	1.158e-52	198.0	COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,47ZN8@7711|Chordata,498TD@7742|Vertebrata,4A16Y@7898|Actinopterygii	33208|Metazoa	E	Si dkey-103j14.5	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
EH1_k127_4931151_0	639282.DEFDS_1268	5.726e-77	266.0	COG0489@1|root,COG0489@2|Bacteria,2GEUR@200930|Deferribacteres	200930|Deferribacteres	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
EH1_k127_4997237_4	1497679.EP56_02480	5.869e-05	48.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,26MFG@186820|Listeriaceae	91061|Bacilli	H	Cys/Met metabolism PLP-dependent enzyme	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH1_k127_4997237_3	633148.Tagg_1095	1.091e-05	48.0	COG0156@1|root,arCOG00113@2157|Archaea,2XPNA@28889|Crenarchaeota	28889|Crenarchaeota	H	pyridoxal phosphate-dependent acyltransferase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH1_k127_4997237_2	7260.FBpp0244249	2.684e-06	59.0	COG4886@1|root,KOG2087@1|root,KOG0619@2759|Eukaryota,KOG2087@2759|Eukaryota,38DRQ@33154|Opisthokonta,3B9GE@33208|Metazoa,3CSEC@33213|Bilateria,41VPE@6656|Arthropoda,3SK59@50557|Insecta,451C3@7147|Diptera,45Q3E@7214|Drosophilidae	33208|Metazoa	T	Protein-hormone receptor activity. It is involved in the biological process described with G-protein coupled receptor signaling pathway	LGR4	GO:0000003,GO:0000139,GO:0001503,GO:0001649,GO:0001653,GO:0001655,GO:0001656,GO:0001667,GO:0001817,GO:0001818,GO:0001822,GO:0001837,GO:0001942,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002682,GO:0002683,GO:0002791,GO:0002792,GO:0003006,GO:0003338,GO:0003674,GO:0004888,GO:0004930,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0006355,GO:0006928,GO:0006950,GO:0007154,GO:0007162,GO:0007165,GO:0007166,GO:0007186,GO:0007218,GO:0007267,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007292,GO:0007297,GO:0007298,GO:0007423,GO:0007548,GO:0007564,GO:0007623,GO:0008150,GO:0008188,GO:0008283,GO:0008528,GO:0008544,GO:0009611,GO:0009653,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0009994,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010631,GO:0010646,GO:0010647,GO:0010648,GO:0012505,GO:0016020,GO:0016021,GO:0016055,GO:0016477,GO:0016500,GO:0019219,GO:0019222,GO:0019953,GO:0022404,GO:0022405,GO:0022407,GO:0022408,GO:0022412,GO:0022414,GO:0022603,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030111,GO:0030154,GO:0030155,GO:0030177,GO:0030282,GO:0030334,GO:0030335,GO:0030539,GO:0030707,GO:0030709,GO:0030855,GO:0031090,GO:0031099,GO:0031214,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031347,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032504,GO:0032588,GO:0032835,GO:0032879,GO:0032880,GO:0032922,GO:0034121,GO:0034122,GO:0035239,GO:0035295,GO:0036335,GO:0038023,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042060,GO:0042127,GO:0042246,GO:0042303,GO:0042592,GO:0042633,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043583,GO:0043588,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045088,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046661,GO:0046849,GO:0048232,GO:0048468,GO:0048477,GO:0048511,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048565,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048608,GO:0048609,GO:0048729,GO:0048731,GO:0048762,GO:0048771,GO:0048806,GO:0048839,GO:0048856,GO:0048869,GO:0048870,GO:0048872,GO:0050673,GO:0050707,GO:0050708,GO:0050709,GO:0050710,GO:0050776,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051223,GO:0051224,GO:0051239,GO:0051240,GO:0051241,GO:0051252,GO:0051253,GO:0051254,GO:0051270,GO:0051272,GO:0051674,GO:0051704,GO:0051716,GO:0055123,GO:0060070,GO:0060089,GO:0060232,GO:0060255,GO:0060429,GO:0060485,GO:0060562,GO:0060688,GO:0060828,GO:0060993,GO:0060995,GO:0061005,GO:0061213,GO:0061217,GO:0061289,GO:0061290,GO:0061326,GO:0061333,GO:0061458,GO:0065007,GO:0065008,GO:0070201,GO:0071944,GO:0072001,GO:0072006,GO:0072009,GO:0072028,GO:0072073,GO:0072078,GO:0072080,GO:0072088,GO:0072170,GO:0072173,GO:0072202,GO:0072204,GO:0072207,GO:0072210,GO:0072224,GO:0072234,GO:0072243,GO:0072273,GO:0072282,GO:0080090,GO:0080134,GO:0090087,GO:0090130,GO:0090132,GO:0090183,GO:0090184,GO:0090189,GO:0090190,GO:0090263,GO:0098588,GO:0098773,GO:0098791,GO:0198738,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1903530,GO:1903531,GO:1904950,GO:1905114,GO:1905330,GO:1905332,GO:1990523,GO:2000026,GO:2000027,GO:2000112,GO:2000113,GO:2000145,GO:2000147,GO:2001013,GO:2001141	-	ko:K04249,ko:K04308,ko:K04309,ko:K08399	ko04024,ko04080,ko04918,ko04923,ko05320,map04024,map04080,map04918,map04923,map05320	-	-	-	ko00000,ko00001,ko04030	-	-	-	7tm_1,LRRNT,LRR_8
EH1_k127_5018910_4	439481.Aboo_0134	1.956e-05	57.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
EH1_k127_5018910_2	1121459.AQXE01000010_gene1976	1.986e-45	171.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,42NN1@68525|delta/epsilon subdivisions,2WQFN@28221|Deltaproteobacteria,2M92T@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
EH1_k127_5018910_3	926561.KB900617_gene2306	1.508e-26	112.0	COG1144@1|root,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24NFD@186801|Clostridia,3WC0G@53433|Halanaerobiales	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
EH1_k127_5018910_0	857293.CAAU_2290	3.979e-118	393.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,36DRE@31979|Clostridiaceae	186801|Clostridia	C	ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
EH1_k127_5018910_1	768672.Desfe_0502	4.916e-102	341.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
EH1_k127_5019776_0	266117.Rxyl_1658	1.908e-33	136.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	CP_0969	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
EH1_k127_5019776_1	1236689.MMALV_15340	5.054e-26	119.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,3F2PH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	RIO1 family	rio1	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
EH1_k127_5019776_2	694429.Pyrfu_0637	1.537e-24	114.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRIJ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_5055531_7	1220534.B655_1002	4.746e-10	71.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
EH1_k127_5055531_0	1242864.D187_001221	2.929e-130	426.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,42M0Z@68525|delta/epsilon subdivisions,2WK36@28221|Deltaproteobacteria,2Z0TJ@29|Myxococcales	28221|Deltaproteobacteria	P	arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
EH1_k127_5055531_1	264732.Moth_2220	2.999e-49	178.0	COG1148@1|root,COG1148@2|Bacteria,1V4NY@1239|Firmicutes,24IAD@186801|Clostridia,42IDC@68295|Thermoanaerobacterales	186801|Clostridia	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5055531_4	2325.TKV_c19110	9.225e-26	109.0	COG1146@1|root,COG1146@2|Bacteria,1VAMF@1239|Firmicutes,24ND9@186801|Clostridia,42IEN@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
EH1_k127_5055531_2	1031288.AXAA01000034_gene2180	4.624e-36	147.0	COG0509@1|root,COG4273@1|root,COG0509@2|Bacteria,COG4273@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,36JKI@31979|Clostridiaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	DGC,GCV_H
EH1_k127_5055531_5	643648.Slip_2187	2.275e-22	102.0	COG4273@1|root,COG4273@2|Bacteria,1VBRH@1239|Firmicutes,24N2C@186801|Clostridia	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
EH1_k127_5055531_3	2325.TKV_c19080	1.399e-30	127.0	2DMSV@1|root,32TFU@2|Bacteria,1VC0G@1239|Firmicutes,24Q3V@186801|Clostridia,42IQ0@68295|Thermoanaerobacterales	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
EH1_k127_5055531_6	443143.GM18_2397	5.403e-14	75.0	COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
EH1_k127_5055531_9	1041930.Mtc_1670	2.54e-05	55.0	COG2314@1|root,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM2,zf-ribbon_3,zinc_ribbon_2
EH1_k127_5055531_8	926569.ANT_27110	7.356e-07	60.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5066161_9	1434929.X946_2187	0.0005446	45.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,1K3P4@119060|Burkholderiaceae	28216|Betaproteobacteria	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
EH1_k127_5066161_4	694429.Pyrfu_1605	1.415e-44	168.0	COG1676@1|root,arCOG01701@2157|Archaea,2XQJB@28889|Crenarchaeota	28889|Crenarchaeota	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
EH1_k127_5066161_7	999630.TUZN_1614	3.361e-06	53.0	arCOG05464@1|root,arCOG05464@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5066161_3	1295642.H839_17018	7.982e-45	175.0	COG2144@1|root,COG2144@2|Bacteria,1UN01@1239|Firmicutes	1239|Firmicutes	S	AIR synthase related protein, N-terminal domain	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
EH1_k127_5066161_8	1459636.NTE_00679	0.0001689	46.0	arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5066161_5	589924.Ferp_1646	4.252e-26	111.0	COG2005@1|root,arCOG00223@2157|Archaea,2Y7ZI@28890|Euryarchaeota,247AB@183980|Archaeoglobi	183980|Archaeoglobi	K	transcriptional regulator, ModE family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
EH1_k127_5066161_6	397288.C806_02650	2.104e-20	104.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,27K6Y@186928|unclassified Lachnospiraceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
EH1_k127_5066161_2	523845.AQXV01000053_gene725	5.057e-91	317.0	COG3276@1|root,arCOG01564@2157|Archaea,2Y862@28890|Euryarchaeota,23QEK@183939|Methanococci	183939|Methanococci	J	elongation factor Tu domain 2 protein	selB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2
EH1_k127_5066161_0	426368.MmarC7_1617	6.106e-96	330.0	KOG4482@1|root,arCOG00119@2157|Archaea,2XV24@28890|Euryarchaeota,23Q57@183939|Methanococci	183939|Methanococci	J	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	spcS	-	2.9.1.2	ko:K03341	ko00450,ko00970,map00450,map00970	-	R08224	RC02965,RC02966	ko00000,ko00001,ko01000	-	-	-	SepSecS
EH1_k127_5066161_1	224325.AF_1299	8.822e-92	312.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
EH1_k127_5101816_0	521011.Mpal_0671	1.585e-51	190.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
EH1_k127_5110115_4	186497.PF1832	2.53e-13	72.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,243S1@183968|Thermococci	183968|Thermococci	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
EH1_k127_5110115_2	1128421.JAGA01000003_gene3292	1.607e-27	119.0	COG0720@1|root,COG0720@2|Bacteria,2NR6T@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
EH1_k127_5110115_0	1365176.N186_05120	2.994e-163	532.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
EH1_k127_5110115_3	391623.TERMP_00815	1.447e-15	81.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,244GA@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
EH1_k127_5110115_1	888832.HMPREF9420_2503	3.001e-60	222.0	COG2189@1|root,COG2189@2|Bacteria,4NFKE@976|Bacteroidetes	976|Bacteroidetes	L	Adenine specific DNA methylase Mod	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH1_k127_5137296_0	1121456.ATVA01000012_gene2681	4.985e-67	234.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2M9B4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
EH1_k127_5159498_0	589924.Ferp_0942	3.927e-57	205.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
EH1_k127_5164903_0	515635.Dtur_1152	8.799e-54	202.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
EH1_k127_5164903_1	485913.Krac_9015	2.849e-31	130.0	COG3845@1|root,COG3845@2|Bacteria,2G625@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
EH1_k127_5168041_0	439235.Dalk_0051	1.224e-95	321.0	COG1145@1|root,COG1145@2|Bacteria	439235.Dalk_0051|-	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5168041_2	1232429.CBLL010000055_gene1245	1.342e-05	59.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,1W7F6@1268|Micrococcaceae	201174|Actinobacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
EH1_k127_5168041_1	694430.Natoc_3050	2.652e-62	224.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23STH@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
EH1_k127_5202110_2	877455.Metbo_2075	1.312e-29	127.0	COG0560@1|root,COG1340@1|root,arCOG01158@2157|Archaea,arCOG01159@2157|Archaea,2XT0C@28890|Euryarchaeota,23NM8@183925|Methanobacteria	183925|Methanobacteria	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD,Hydrolase
EH1_k127_5202110_0	186497.PF0767	1.012e-91	314.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci	183968|Thermococci	E	Beta-eliminating lyase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
EH1_k127_5202110_3	797299.HALLA_17330	1.959e-08	63.0	COG3815@1|root,arCOG03949@2157|Archaea,2XZ2C@28890|Euryarchaeota,23X0I@183963|Halobacteria	183963|Halobacteria	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
EH1_k127_5202110_4	1463821.JOGR01000010_gene3874	1.219e-05	52.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4F04M@85014|Glycomycetales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH1_k127_5202110_1	439235.Dalk_2984	3.687e-33	135.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2MI3F@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD1	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_5208005_4	1123278.KB893609_gene4495	3.267e-07	55.0	COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,47MY4@768503|Cytophagia	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_5208005_2	368407.Memar_0905	4.358e-52	188.0	arCOG03001@1|root,arCOG03001@2157|Archaea,2Y6YJ@28890|Euryarchaeota,2NATB@224756|Methanomicrobia	224756|Methanomicrobia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
EH1_k127_5208005_5	224325.AF_2234	4.392e-05	51.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
EH1_k127_5208005_0	1220534.B655_0237	1.223e-99	332.0	arCOG06481@1|root,arCOG06481@2157|Archaea,2XV5Y@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5208005_1	102125.Xen7305DRAFT_00002800	3.92e-56	209.0	COG2334@1|root,COG5285@1|root,COG2334@2|Bacteria,COG5285@2|Bacteria,1G486@1117|Cyanobacteria	1117|Cyanobacteria	Q	Phytanoyl-CoA dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
EH1_k127_5212368_3	479434.Sthe_2328	2.904e-71	249.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,27Z66@189775|Thermomicrobia	189775|Thermomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_5212368_4	1166018.FAES_2080	1.977e-65	237.0	COG0153@1|root,COG0153@2|Bacteria,4NFSD@976|Bacteroidetes,47K00@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
EH1_k127_5212368_1	1379698.RBG1_1C00001G1247	6.652e-119	400.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
EH1_k127_5212368_2	1121324.CLIT_20c00580	4.58e-86	294.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,25QYE@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
EH1_k127_5212368_0	309803.CTN_0956	3.011e-187	599.0	COG2759@1|root,COG2759@2|Bacteria,2GBYR@200918|Thermotogae	200918|Thermotogae	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
EH1_k127_5212368_5	304371.MCP_0354	1.785e-11	71.0	COG2202@1|root,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea,2Y7SW@28890|Euryarchaeota,2NB2A@224756|Methanomicrobia	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
EH1_k127_5224825_3	342949.PNA2_1018	7.324e-92	319.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUJT@28890|Euryarchaeota,245AW@183968|Thermococci	183968|Thermococci	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
EH1_k127_5224825_2	555079.Toce_0871	2.65e-109	370.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
EH1_k127_5224825_0	573063.Metin_0604	1.213e-124	412.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23QNJ@183939|Methanococci	183939|Methanococci	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
EH1_k127_5224825_1	243232.MJ_1612	2.304e-116	387.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,23PZZ@183939|Methanococci	183939|Methanococci	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
EH1_k127_5224825_4	186497.PF1631	3.195e-91	316.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y2ZW@28890|Euryarchaeota,245AV@183968|Thermococci	183968|Thermococci	M	UDP binding domain	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
EH1_k127_5247979_0	693661.Arcve_2050	8.639e-23	112.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
EH1_k127_5247979_1	1288494.EBAPG3_18060	4.159e-16	89.0	COG0110@1|root,COG0110@2|Bacteria,1RBYA@1224|Proteobacteria,2VRA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
EH1_k127_5249485_0	867845.KI911784_gene975	2.178e-90	318.0	COG1132@1|root,COG1132@2|Bacteria,2G63W@200795|Chloroflexi,377YS@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
EH1_k127_5249485_2	572546.Arcpr_1414	1.372e-37	148.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2465V@183980|Archaeoglobi	183980|Archaeoglobi	S	Zinc finger domain	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
EH1_k127_5249485_1	1459636.NTE_00038	1.494e-53	191.0	COG0346@1|root,arCOG02708@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
EH1_k127_5320584_8	1265505.ATUG01000002_gene1768	2.693e-29	125.0	COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MMZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
EH1_k127_5320584_6	572547.Amico_1777	1.644e-44	184.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_5320584_10	1132441.KI519455_gene3723	0.0002903	54.0	COG0747@1|root,COG0747@2|Bacteria,2GK4Y@201174|Actinobacteria,1WC9Y@1268|Micrococcaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_5320584_9	1231241.Mc24_05465	4.778e-13	83.0	COG0747@1|root,COG0747@2|Bacteria,2GCPN@200918|Thermotogae	200918|Thermotogae	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_5320584_5	555079.Toce_0806	1.798e-49	185.0	COG4656@1|root,COG4656@2|Bacteria,1TS9H@1239|Firmicutes,24DQ7@186801|Clostridia,42FJ0@68295|Thermoanaerobacterales	186801|Clostridia	C	Methylene-tetrahydrofolate reductase C terminal	metV	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
EH1_k127_5320584_4	1041930.Mtc_0091	2.722e-63	233.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2N99S@224756|Methanomicrobia	224756|Methanomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
EH1_k127_5320584_0	224719.Abm4_1021	4.359e-139	466.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,23NJG@183925|Methanobacteria	183925|Methanobacteria	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
EH1_k127_5320584_3	1104324.P186_0922	7.449e-90	309.0	COG3839@1|root,arCOG00177@2157|Archaea,2XSPU@28889|Crenarchaeota	28889|Crenarchaeota	E	COGs COG3842 ABC-type spermidine putrescine transport systems ATPase components	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
EH1_k127_5320584_1	391623.TERMP_01190	1.015e-117	404.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,242Z4@183968|Thermococci	183968|Thermococci	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
EH1_k127_5320584_2	604354.TSIB_0222	1.05e-95	331.0	COG1840@1|root,arCOG00221@2157|Archaea,2Y33A@28890|Euryarchaeota,243E5@183968|Thermococci	183968|Thermococci	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
EH1_k127_5320584_7	1343739.PAP_05485	8.664e-31	140.0	COG4945@1|root,arCOG01310@2157|Archaea,arCOG03771@2157|Archaea,2XSTV@28890|Euryarchaeota,245KU@183968|Thermococci	183968|Thermococci	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C,PEGA
EH1_k127_5374537_1	1459636.NTE_02874	8.261e-12	77.0	COG2404@1|root,arCOG00423@2157|Archaea	2157|Archaea	S	phosphohydrolase (DHH superfamily)	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	-
EH1_k127_5374537_0	1365176.N186_05425	2.19e-72	258.0	COG4231@1|root,arCOG01609@2157|Archaea,2XPN3@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
EH1_k127_5380477_10	1041930.Mtc_0893	9.203e-07	57.0	COG1510@1|root,arCOG02795@2157|Archaea,2XWWY@28890|Euryarchaeota	28890|Euryarchaeota	K	Belongs to the GbsR family	-	-	-	ko:K22109	-	-	-	-	ko00000,ko03000	-	-	-	HTH_27,HTH_IclR,MarR,MarR_2
EH1_k127_5380477_3	1273538.G159_05145	1.967e-85	293.0	COG0596@1|root,COG0596@2|Bacteria,1V055@1239|Firmicutes,4HGD3@91061|Bacilli	91061|Bacilli	S	Hydrolase, alpha beta domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
EH1_k127_5380477_1	484770.UFO1_3311	5.707e-121	400.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4H27J@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
EH1_k127_5380477_2	401526.TcarDRAFT_1837	9.1e-87	294.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H2QE@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
EH1_k127_5380477_0	1041930.Mtc_1252	6.55e-125	414.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
EH1_k127_5380477_11	768671.ThimaDRAFT_1525	0.000394	49.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,1RR2P@1236|Gammaproteobacteria,1WVXQ@135613|Chromatiales	135613|Chromatiales	O	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_16,TPR_8
EH1_k127_5380477_8	386456.JQKN01000015_gene2953	3.332e-11	68.0	COG1708@1|root,arCOG02105@2157|Archaea,2Y07F@28890|Euryarchaeota	28890|Euryarchaeota	S	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
EH1_k127_5380477_4	591019.Shell_1440	3.547e-41	156.0	COG0185@1|root,arCOG04099@2157|Archaea,2XQBR@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
EH1_k127_5380477_5	649831.L083_6545	1.682e-32	141.0	COG4552@1|root,COG4552@2|Bacteria,2IE60@201174|Actinobacteria,4DCAW@85008|Micromonosporales	201174|Actinobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
EH1_k127_5380477_9	1415780.JPOG01000001_gene3161	1.415e-07	59.0	2DT9D@1|root,33JAN@2|Bacteria,1NK8G@1224|Proteobacteria,1SJ00@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5380477_7	994573.T472_0209625	1.349e-11	73.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,Peptidase_M73
EH1_k127_5505949_2	304371.MCP_1561	1.389e-36	147.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,2NAHK@224756|Methanomicrobia	224756|Methanomicrobia	E	oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH1_k127_5505949_1	351160.LRC379	5.522e-82	294.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,2N9GM@224756|Methanomicrobia	224756|Methanomicrobia	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH1_k127_5505949_0	351160.LRC378	2.268e-102	344.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota,2NAQG@224756|Methanomicrobia	224756|Methanomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH1_k127_5510333_12	634500.EbC_30340	1.047e-06	64.0	COG2373@1|root,COG2911@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	PFAM FecR protein	yeeJ	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
EH1_k127_5510333_2	386456.JQKN01000001_gene1892	4.283e-119	401.0	COG0479@1|root,arCOG00963@2157|Archaea,2Y85K@28890|Euryarchaeota,23PZE@183925|Methanobacteria	183925|Methanobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
EH1_k127_5510333_0	1220534.B655_1070	1.882e-151	499.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	sdhA	-	1.3.4.1	ko:K18209	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
EH1_k127_5510333_7	743719.PaelaDRAFT_3980	2.201e-41	161.0	COG0454@1|root,COG0456@2|Bacteria,1V2CK@1239|Firmicutes,4HGP5@91061|Bacilli,26WI0@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yyaR	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_5510333_5	673860.AciM339_1147	1.1e-63	224.0	COG1838@1|root,arCOG04406@2157|Archaea,2XXBQ@28890|Euryarchaeota,3F2QU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
EH1_k127_5510333_3	1343739.PAP_05865	5.505e-87	296.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,242SI@183968|Thermococci	183968|Thermococci	C	Fumarate hydratase	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
EH1_k127_5510333_6	1343739.PAP_05715	5.776e-61	218.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
EH1_k127_5510333_9	1042877.GQS_02795	3.694e-12	73.0	COG1522@1|root,arCOG01580@2157|Archaea,2XYWZ@28890|Euryarchaeota,24443@183968|Thermococci	183968|Thermococci	K	Homeodomain-like domain	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_AsnC-type
EH1_k127_5510333_1	529709.PYCH_07400	5.789e-124	423.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
EH1_k127_5510333_8	269797.Mbar_A0964	8.717e-29	124.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH1_k127_5510333_11	1500259.JQLD01000008_gene1980	4.619e-07	61.0	COG0517@1|root,COG0517@2|Bacteria,1NCNH@1224|Proteobacteria,2UHM3@28211|Alphaproteobacteria,4BBGV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
EH1_k127_5510333_4	1293047.CBMA010000042_gene2609	1.933e-70	255.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,23TFD@183963|Halobacteria	183963|Halobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3,3.5.2.5	ko:K01465,ko:K01466	ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120	M00051,M00546	R01993,R02425	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
EH1_k127_5510333_10	1343739.PAP_06535	6.925e-12	66.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
EH1_k127_5524642_0	1499967.BAYZ01000095_gene4068	2.052e-49	188.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
EH1_k127_5524642_1	411476.BACOVA_01460	1.452e-19	100.0	COG2220@1|root,COG2220@2|Bacteria,4NFJ4@976|Bacteroidetes,2FNMD@200643|Bacteroidia,4AQS7@815|Bacteroidaceae	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
EH1_k127_5524642_2	1227500.C494_20368	2.551e-10	67.0	COG1715@1|root,arCOG02777@2157|Archaea	2157|Archaea	V	restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
EH1_k127_5531580_2	1220534.B655_1031	4.004e-52	192.0	COG0348@1|root,arCOG02772@2157|Archaea,2Y033@28890|Euryarchaeota,23PTT@183925|Methanobacteria	183925|Methanobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
EH1_k127_5531580_4	1205680.CAKO01000035_gene316	8.121e-32	129.0	COG0454@1|root,COG0456@2|Bacteria,1N6QA@1224|Proteobacteria,2UFGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_5531580_6	1123277.KB893181_gene2301	0.0003462	48.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.23	ko:K01054	ko00561,ko01100,ko04714,ko04723,ko04923,map00561,map01100,map04714,map04723,map04923	M00098	R01351	RC00020,RC00041	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Hydrolase_4
EH1_k127_5531580_5	500632.CLONEX_00736	4.636e-06	59.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_5531580_0	43759.JNWK01000020_gene7372	7.117e-69	244.0	COG0388@1|root,COG0388@2|Bacteria,2GP6F@201174|Actinobacteria	201174|Actinobacteria	S	Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
EH1_k127_5531580_1	547559.Nmag_0094	1.996e-59	215.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU0U@28890|Euryarchaeota,23UUW@183963|Halobacteria	183963|Halobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
EH1_k127_5531580_3	547559.Nmag_0094	2.422e-39	152.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU0U@28890|Euryarchaeota,23UUW@183963|Halobacteria	183963|Halobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
EH1_k127_55523_0	351160.LRC377	2.464e-79	288.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_55523_1	868131.MSWAN_2092	3.928e-40	155.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota	28890|Euryarchaeota	C	nitroreductase	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
EH1_k127_5577539_13	4896.SPBC577.02.1	9.008e-07	53.0	KOG3499@1|root,KOG3499@2759|Eukaryota,3A8NK@33154|Opisthokonta,3P6UD@4751|Fungi,3QXEW@4890|Ascomycota,3MD1R@451866|Taphrinomycotina	4751|Fungi	J	Belongs to the eukaryotic ribosomal protein eL38 family	RPL38	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
EH1_k127_5577539_1	1131266.ARWQ01000001_gene1211	7.417e-87	302.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
EH1_k127_5577539_11	224325.AF_1956	1.932e-22	101.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,246D0@183980|Archaeoglobi	183980|Archaeoglobi	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
EH1_k127_5577539_12	436308.Nmar_1065	1.455e-11	72.0	COG0195@1|root,arCOG01761@2157|Archaea,41T4Q@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5577539_3	368407.Memar_1399	6.786e-59	223.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
EH1_k127_5577539_8	1343739.PAP_09105	1.648e-38	147.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
EH1_k127_5577539_2	192952.MM_3299	8.342e-62	228.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
EH1_k127_5577539_0	573063.Metin_1078	1.181e-95	329.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,23QN9@183939|Methanococci	183939|Methanococci	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
EH1_k127_5577539_9	591019.Shell_0022	5.088e-27	112.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
EH1_k127_5577539_14	224719.Abm4_1659	2.126e-06	54.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,23P6P@183925|Methanobacteria	183925|Methanobacteria	K	RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
EH1_k127_5577539_6	589924.Ferp_0274	7.21e-42	160.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,246VN@183980|Archaeoglobi	183980|Archaeoglobi	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
EH1_k127_5577539_5	304371.MCP_0726	1.228e-49	188.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
EH1_k127_5577539_10	868131.MSWAN_2293	7.324e-23	106.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23P23@183925|Methanobacteria	183925|Methanobacteria	Q	Lysine methyltransferase	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
EH1_k127_5577539_7	1459636.NTE_02621	3.002e-39	156.0	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
EH1_k127_5577539_4	573063.Metin_1190	1.328e-51	192.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23QK3@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
EH1_k127_5579784_0	673860.AciM339_0619	1.434e-55	209.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,3F2HE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,Rad51
EH1_k127_5579784_1	1121899.Q764_11365	2.796e-45	183.0	COG1541@1|root,COG1541@2|Bacteria,4NFRI@976|Bacteroidetes,1HXCK@117743|Flavobacteriia,2NS8V@237|Flavobacterium	976|Bacteroidetes	H	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
EH1_k127_5579784_2	29581.BW37_04636	9.105e-06	56.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH1_k127_5652529_6	673860.AciM339_0382	5.56e-19	96.0	COG1196@1|root,arCOG01917@1|root,arCOG02452@1|root,arCOG00371@2157|Archaea,arCOG01917@2157|Archaea,arCOG02452@2157|Archaea,2Y71H@28890|Euryarchaeota,3F35U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
EH1_k127_5652529_2	246969.TAM4_666	3.59e-47	178.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
EH1_k127_5652529_8	1220534.B655_1011	0.0001412	49.0	COG0526@1|root,arCOG01218@2157|Archaea,2Y8A7@28890|Euryarchaeota,23P7K@183925|Methanobacteria	183925|Methanobacteria	O	Redox-active disulfide protein 1	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
EH1_k127_5652529_9	1379698.RBG1_1C00001G1746	0.0006993	48.0	COG2018@1|root,COG2018@2|Bacteria,2NRUR@2323|unclassified Bacteria	2|Bacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
EH1_k127_5652529_4	4555.Si007215m	5.01e-42	160.0	COG1100@1|root,KOG0087@2759|Eukaryota,37JIN@33090|Viridiplantae,3GGID@35493|Streptophyta,3KN4T@4447|Liliopsida,3I7A6@38820|Poales	35493|Streptophyta	U	Ras family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005794,GO:0008150,GO:0009504,GO:0009987,GO:0012505,GO:0031410,GO:0031982,GO:0042546,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071554,GO:0071840,GO:0097708	-	ko:K07904	ko04144,ko04961,ko04962,ko04972,map04144,map04961,map04962,map04972	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_5652529_1	5180.EDO03054	2.258e-50	193.0	KOG0272@1|root,KOG0295@1|root,KOG0272@2759|Eukaryota,KOG0295@2759|Eukaryota,3AFR9@33154|Opisthokonta,3Q43U@4751|Fungi,3RM8R@4890|Ascomycota	4751|Fungi	A	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	HET,NACHT,WD40
EH1_k127_5652529_5	5825.PCHAS_111190	5.669e-34	138.0	KOG0084@1|root,KOG0084@2759|Eukaryota,3Y9SJ@5794|Apicomplexa,3KBWP@422676|Aconoidasida,3YXE9@5819|Haemosporida	422676|Aconoidasida	U	Ras subfamily of RAS small GTPases	rab1	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_5652529_7	1033806.HTIA_p2959	1.259e-05	51.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XXYB@28890|Euryarchaeota,23WG9@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5652529_0	1459636.NTE_00007	2.846e-109	382.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
EH1_k127_5652529_3	413816.BBJP01000057_gene2615	1.105e-45	178.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23S8R@183963|Halobacteria	183963|Halobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
EH1_k127_5672991_0	868595.Desca_0676	1.31e-09	65.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese
EH1_k127_5694152_38	694429.Pyrfu_0798	5.583e-18	89.0	COG0640@1|root,arCOG01679@2157|Archaea,2XR0G@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
EH1_k127_5694152_11	304371.MCP_0137	7.401e-98	345.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
EH1_k127_5694152_44	1459636.NTE_01725	4.753e-13	72.0	COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
EH1_k127_5694152_7	868131.MSWAN_2418	4.625e-115	380.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
EH1_k127_5694152_24	1042877.GQS_01350	2.23e-42	163.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
EH1_k127_5694152_26	391623.TERMP_00896	3.06e-40	153.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,243T7@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
EH1_k127_5694152_51	868131.MSWAN_0491	5.614e-05	55.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,23NMN@183925|Methanobacteria	183925|Methanobacteria	L	DHHA1 domain	recJ2	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
EH1_k127_5694152_52	436308.Nmar_1510	8.879e-05	48.0	arCOG01354@1|root,arCOG01354@2157|Archaea,41T7T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transcription factor Pcc1	-	-	-	-	-	-	-	-	-	-	-	-	Pcc1
EH1_k127_5694152_19	70601.3256503	1.502e-64	239.0	COG1530@1|root,arCOG04307@2157|Archaea,2XUGB@28890|Euryarchaeota,243F3@183968|Thermococci	183968|Thermococci	J	Binds to RNA in loop regions with AU-rich sequences	aubA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K22469	-	-	-	-	ko00000,ko03009	-	-	-	DUF402,RNase_E_G
EH1_k127_5694152_36	386456.JQKN01000018_gene594	1.342e-20	93.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
EH1_k127_5694152_46	572478.Vdis_1228	1.472e-11	70.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
EH1_k127_5694152_21	1163730.FFONT_0433	1.166e-46	179.0	COG1890@1|root,arCOG04186@2157|Archaea,2XPNX@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
EH1_k127_5694152_37	994573.T472_0217350	3.153e-18	93.0	COG2020@1|root,COG2020@2|Bacteria,1VKIT@1239|Firmicutes,24D8X@186801|Clostridia,36EBB@31979|Clostridiaceae	186801|Clostridia	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
EH1_k127_5694152_34	1125699.HMPREF9194_02210	4.129e-24	112.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
EH1_k127_5694152_39	1408304.JAHA01000007_gene1470	1.875e-17	93.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24H8J@186801|Clostridia,4BY6N@830|Butyrivibrio	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
EH1_k127_5694152_53	266265.Bxe_A1336	0.0007889	49.0	COG3415@1|root,COG3415@2|Bacteria,1QWH5@1224|Proteobacteria,2WGZX@28216|Betaproteobacteria,1K7FZ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
EH1_k127_5694152_10	604354.TSIB_1776	3.948e-99	341.0	COG1109@1|root,arCOG00767@2157|Archaea,2XTYZ@28890|Euryarchaeota,242U1@183968|Thermococci	183968|Thermococci	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.7	ko:K22199	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
EH1_k127_5694152_32	1459636.NTE_02598	9.102e-36	149.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
EH1_k127_5694152_14	1041930.Mtc_0452	1.897e-86	308.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
EH1_k127_5694152_33	648996.Theam_1390	5.39e-28	122.0	COG1100@1|root,COG1100@2|Bacteria,2G4DJ@200783|Aquificae	200783|Aquificae	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Gtr1_RagA
EH1_k127_5694152_15	1459636.NTE_01027	2.263e-74	266.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
EH1_k127_5694152_17	69014.TK1688	1.134e-66	235.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
EH1_k127_5694152_20	572478.Vdis_1780	2.147e-53	200.0	COG1100@1|root,arCOG01225@2157|Archaea,2XQ2Q@28889|Crenarchaeota	28889|Crenarchaeota	S	ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
EH1_k127_5694152_28	386456.JQKN01000002_gene2681	3.456e-37	153.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
EH1_k127_5694152_43	246969.TAM4_533	2.692e-13	75.0	COG1931@1|root,arCOG01043@2157|Archaea,2Y0M1@28890|Euryarchaeota,2440X@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
EH1_k127_5694152_23	272844.PAB1725	4.046e-43	164.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2433T@183968|Thermococci	183968|Thermococci	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
EH1_k127_5694152_12	1220534.B655_0417	1.117e-94	322.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,23NRE@183925|Methanobacteria	183925|Methanobacteria	O	AAA ATPase	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
EH1_k127_5694152_30	1198449.ACAM_1123	2.347e-36	145.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
EH1_k127_5694152_16	224325.AF_0130	1.38e-73	260.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
EH1_k127_5694152_1	192952.MM_0425	3.412e-176	577.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
EH1_k127_5694152_4	765177.Desmu_0578	4.726e-159	526.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
EH1_k127_5694152_9	573064.Mefer_1399	8.089e-100	335.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
EH1_k127_5694152_18	415426.Hbut_0906	2.46e-65	238.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
EH1_k127_5694152_31	877455.Metbo_1952	5.765e-36	147.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,23NZW@183925|Methanobacteria	183925|Methanobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
EH1_k127_5694152_47	666510.ASAC_1325	7.864e-10	63.0	COG0640@1|root,arCOG04056@2157|Archaea,2XR0A@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
EH1_k127_5694152_13	694429.Pyrfu_1938	2.979e-88	306.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
EH1_k127_5694152_8	573063.Metin_0090	3.797e-111	371.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23RI4@183939|Methanococci	183939|Methanococci	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
EH1_k127_5694152_41	797304.Natgr_0385	3.276e-15	87.0	COG1405@1|root,arCOG01981@2157|Archaea,2XSYE@28890|Euryarchaeota,23SMK@183963|Halobacteria	183963|Halobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbA5	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
EH1_k127_5694152_35	1033806.HTIA_0209	2.395e-23	115.0	COG4962@1|root,arCOG01818@2157|Archaea,2XTN5@28890|Euryarchaeota,23STY@183963|Halobacteria	183963|Halobacteria	N	COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
EH1_k127_5694152_50	69014.TK0421	1.771e-05	48.0	arCOG07843@1|root,arCOG07843@2157|Archaea	69014.TK0421|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5694152_49	877455.Metbo_1600	7.351e-06	59.0	arCOG02487@1|root,arCOG02555@1|root,arCOG03270@1|root,arCOG02487@2157|Archaea,arCOG02555@2157|Archaea,arCOG03270@2157|Archaea,2Y7UE@28890|Euryarchaeota,23PA5@183925|Methanobacteria	183925|Methanobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
EH1_k127_5694152_42	1122138.AQUZ01000002_gene2006	3.204e-14	88.0	COG0433@1|root,COG0433@2|Bacteria,2I07V@201174|Actinobacteria,4DW55@85009|Propionibacteriales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5694152_29	339860.Msp_0857	5.367e-37	150.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH1_k127_5694152_27	269797.Mbar_A3684	8.764e-39	148.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,2N9T3@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
EH1_k127_5694152_0	195522.BD01_0959	2.241e-178	577.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
EH1_k127_5694152_25	1045004.OKIT_0676	5.539e-41	167.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,4AWWC@81850|Leuconostocaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
EH1_k127_5694152_45	1463900.JOIX01000070_gene4482	2.325e-12	78.0	COG1665@1|root,COG1665@2|Bacteria,2IBEY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
EH1_k127_5694152_48	351160.RCIX2718	7.191e-09	64.0	arCOG04038@1|root,arCOG04038@2157|Archaea,2Y5TS@28890|Euryarchaeota,2NBDA@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5694152_5	529818.AMSG_04122T0	8.223e-134	439.0	COG1748@1|root,KOG0172@2759|Eukaryota	2759|Eukaryota	E	saccharopine dehydrogenase activity	LYS9	GO:0003674,GO:0003824,GO:0004753,GO:0004755,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.10,2.5.1.16	ko:K00293,ko:K00797	ko00270,ko00300,ko00310,ko00330,ko00410,ko00480,ko01100,ko01110,ko01130,ko01230,map00270,map00300,map00310,map00330,map00410,map00480,map01100,map01110,map01130,map01230	M00030,M00032,M00034,M00133	R01920,R02315,R02869,R08359	RC00021,RC00053,RC00215,RC00225	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP,Spermine_synt_N,Spermine_synth
EH1_k127_5694152_6	1499967.BAYZ01000013_gene6446	3e-128	423.0	COG0686@1|root,COG0686@2|Bacteria,2NNTE@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	sdh	-	1.5.1.7,1.5.1.8,1.5.1.9	ko:K00290,ko:K14157	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R00716,R02313	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
EH1_k127_5694152_2	439481.Aboo_0302	1.493e-175	570.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
EH1_k127_5694152_22	391009.Tmel_0794	4.299e-46	173.0	COG1014@1|root,COG1014@2|Bacteria,2GEBN@200918|Thermotogae	200918|Thermotogae	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
EH1_k127_5694152_3	868131.MSWAN_2243	5.909e-174	573.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
EH1_k127_5694152_40	679926.Mpet_1169	1.945e-16	85.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,2N9F3@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM CoA-binding domain protein	acdAB	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
EH1_k127_571962_2	673860.AciM339_0077	5.869e-05	48.0	COG2517@1|root,arCOG04359@2157|Archaea,2XV20@28890|Euryarchaeota,3F3A3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Putative tRNA binding domain	-	-	-	ko:K07135	-	-	-	-	ko00000	-	-	-	tRNA_bind
EH1_k127_571962_0	649747.HMPREF0083_00323	8.43e-09	61.0	COG1694@1|root,COG1694@2|Bacteria,1VA9N@1239|Firmicutes,4HMTD@91061|Bacilli,26YXN@186822|Paenibacillaceae	91061|Bacilli	S	MazG nucleotide pyrophosphohydrolase domain	yvdC	-	-	-	-	-	-	-	-	-	-	-	MazG
EH1_k127_571962_3	1313421.JHBV01000138_gene1212	0.0002041	54.0	COG1541@1|root,COG1541@2|Bacteria,4NGRR@976|Bacteroidetes,1IP0X@117747|Sphingobacteriia	976|Bacteroidetes	H	AMP-binding enzyme	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
EH1_k127_571962_1	888052.HMPREF9006_0757	7.753e-06	57.0	COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria,4D87D@85005|Actinomycetales	201174|Actinobacteria	A	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
EH1_k127_5729400_0	742818.HMPREF9451_01696	0.0003663	51.0	COG0730@1|root,COG0730@2|Bacteria,2HGFS@201174|Actinobacteria,4CUMD@84998|Coriobacteriia	84998|Coriobacteriia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
EH1_k127_5749913_0	926569.ANT_11560	2.078e-24	119.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
EH1_k127_5749913_1	1128421.JAGA01000002_gene587	1.153e-21	109.0	COG0013@1|root,COG0013@2|Bacteria,2NPQB@2323|unclassified Bacteria	2|Bacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	alaS_2	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
EH1_k127_5752269_3	1117108.PAALTS15_14541	0.000118	55.0	COG1361@1|root,COG1361@2|Bacteria,1V4V3@1239|Firmicutes,4HT0D@91061|Bacilli,26QKX@186822|Paenibacillaceae	91061|Bacilli	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
EH1_k127_5752269_1	604354.TSIB_1067	4.319e-36	149.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTKZ@28890|Euryarchaeota,243BY@183968|Thermococci	183968|Thermococci	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
EH1_k127_5752269_0	453591.Igni_1108	6.64e-93	321.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
EH1_k127_5752269_2	186497.PF0844	8.741e-18	94.0	arCOG02979@1|root,arCOG02979@2157|Archaea,2XT08@28890|Euryarchaeota,242QH@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5777063_0	1054217.TALC_00606	3.502e-101	339.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,241JR@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
EH1_k127_5777063_1	273075.Ta1118	3.222e-13	79.0	arCOG06011@1|root,arCOG06011@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
EH1_k127_5860349_0	1232410.KI421416_gene2685	4.672e-58	206.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WQX0@28221|Deltaproteobacteria,43W25@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K02617,ko:K08279	-	-	-	-	ko00000	-	-	-	Hexapep
EH1_k127_5860349_2	386456.JQKN01000001_gene1821	3.427e-10	70.0	COG1668@1|root,arCOG01462@2157|Archaea,2Y3YK@28890|Euryarchaeota	28890|Euryarchaeota	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
EH1_k127_5860349_1	357808.RoseRS_4617	4.035e-54	199.0	COG1131@1|root,COG1131@2|Bacteria,2G6HA@200795|Chloroflexi,376NC@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH1_k127_5862797_0	384616.Pisl_1038	2.709e-55	205.0	COG3294@1|root,arCOG04230@2157|Archaea,2XQ9R@28889|Crenarchaeota	28889|Crenarchaeota	S	phosphohydrolase	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
EH1_k127_5862797_2	1459636.NTE_02308	3.539e-12	71.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
EH1_k127_5862797_1	246194.CHY_0491	2.333e-42	164.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,42EUH@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
EH1_k127_5894813_2	1449347.JQLN01000005_gene5460	7.795e-08	61.0	COG2146@1|root,COG2146@2|Bacteria,2IFJ5@201174|Actinobacteria,2M1JH@2063|Kitasatospora	201174|Actinobacteria	P	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX,Rieske
EH1_k127_5894813_0	192952.MM_0848	3.905e-41	166.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y29P@28890|Euryarchaeota,2NA5X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_5894813_1	439235.Dalk_0162	9.435e-13	78.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
EH1_k127_5894813_3	439235.Dalk_0163	0.0009869	44.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
EH1_k127_598323_4	868131.MSWAN_0515	1.489e-20	101.0	COG1233@1|root,arCOG01524@2157|Archaea,2XSYN@28890|Euryarchaeota	28890|Euryarchaeota	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
EH1_k127_598323_1	304371.MCP_0732	1.026e-48	177.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
EH1_k127_598323_6	406327.Mevan_1362	9.374e-05	51.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,23QXT@183939|Methanococci	183939|Methanococci	V	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
EH1_k127_598323_0	877455.Metbo_2344	3.061e-50	189.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
EH1_k127_598323_2	368408.Tpen_0409	7.974e-37	144.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
EH1_k127_598323_3	1229520.ADIAL_2110	2.634e-36	153.0	COG0657@1|root,COG0657@2|Bacteria,1UYX6@1239|Firmicutes,4HEMG@91061|Bacilli	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
EH1_k127_598323_5	644107.SL1157_2208	5.863e-12	74.0	COG0406@1|root,COG0406@2|Bacteria,1R896@1224|Proteobacteria,2U4QW@28211|Alphaproteobacteria,4NCE0@97050|Ruegeria	28211|Alphaproteobacteria	G	Histidine phosphatase superfamily (branch 1)	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
EH1_k127_6010795_3	1401078.HMPREF2140_00800	1.143e-44	177.0	COG0827@1|root,COG0827@2|Bacteria,4P1K4@976|Bacteroidetes,2FX1M@200643|Bacteroidia	976|Bacteroidetes	L	Eco57I restriction-modification methylase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6010795_1	1401078.HMPREF2140_00805	3.965e-79	280.0	COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,2FNPZ@200643|Bacteroidia	976|Bacteroidetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
EH1_k127_6010795_5	128390.XP_009459445.1	3.726e-08	66.0	COG1100@1|root,KOG0070@2759|Eukaryota,38DZB@33154|Opisthokonta,3BDDU@33208|Metazoa,3CV17@33213|Bilateria,48938@7711|Chordata,48ZG2@7742|Vertebrata,4GQ8X@8782|Aves	33208|Metazoa	U	ADP-ribosylation factor-like	ARL4A	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030154,GO:0031974,GO:0031981,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045444,GO:0048869,GO:0050873,GO:0070013,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K07945	-	-	-	-	ko00000,ko04031	-	-	-	Arf
EH1_k127_6010795_4	384616.Pisl_0558	6.835e-44	183.0	COG1236@1|root,arCOG00541@2157|Archaea,2XPVA@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
EH1_k127_6010795_2	1459636.NTE_01921	2.256e-52	199.0	COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota	651137|Thaumarchaeota	HK	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
EH1_k127_6010795_0	386456.JQKN01000002_gene2775	1.457e-88	302.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,23NN6@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
EH1_k127_6010795_6	1163730.FFONT_0114	0.0001564	51.0	COG0637@1|root,arCOG02293@2157|Archaea	2157|Archaea	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
EH1_k127_6030441_1	456442.Mboo_1535	3.046e-05	49.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
EH1_k127_6030441_0	1047013.AQSP01000134_gene1338	6.96e-100	343.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
EH1_k127_6031945_4	234267.Acid_7487	0.0009906	45.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
EH1_k127_6031945_1	591019.Shell_0525	1.992e-71	252.0	COG0451@1|root,arCOG01369@2157|Archaea,2XPYT@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
EH1_k127_6031945_2	415426.Hbut_0120	8.244e-13	69.0	COG3609@1|root,arCOG01009@2157|Archaea,2XR62@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
EH1_k127_6031945_3	1304874.JAFY01000005_gene1119	4.023e-08	61.0	COG2345@1|root,COG2345@2|Bacteria,3TBFY@508458|Synergistetes	508458|Synergistetes	K	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
EH1_k127_6031945_0	429009.Adeg_1700	2.477e-176	569.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
EH1_k127_6046952_4	633148.Tagg_0667	4.289e-57	208.0	COG1571@1|root,arCOG01115@2157|Archaea,2XPN1@28889|Crenarchaeota	28889|Crenarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
EH1_k127_6046952_27	444157.Tneu_1465	3.353e-08	60.0	arCOG07221@1|root,arCOG07221@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-HIT
EH1_k127_6046952_10	386456.JQKN01000001_gene2093	7.539e-45	168.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,23P0G@183925|Methanobacteria	183925|Methanobacteria	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
EH1_k127_6046952_0	386456.JQKN01000001_gene1733	7.167e-115	379.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,23NQV@183925|Methanobacteria	183925|Methanobacteria	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
EH1_k127_6046952_18	1365176.N186_03270	1.862e-30	122.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
EH1_k127_6046952_13	644281.MFS40622_1528	1.072e-40	156.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,23QTJ@183939|Methanococci	183939|Methanococci	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
EH1_k127_6046952_30	178306.PAE3224	0.0006279	48.0	COG2174@1|root,arCOG04168@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL34 family	rpl34e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
EH1_k127_6046952_28	573063.Metin_0611	1.14e-07	60.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23QBG@183939|Methanococci	183939|Methanococci	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
EH1_k127_6046952_9	419665.Maeo_1130	4.304e-47	175.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,23Q7F@183939|Methanococci	183939|Methanococci	F	ATP-AMP transphosphorylase	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
EH1_k127_6046952_1	99158.XP_008882380.1	8.628e-104	358.0	COG0201@1|root,KOG1373@2759|Eukaryota,3Y9GN@5794|Apicomplexa,3YIXE@5796|Coccidia,3YV0B@5809|Sarcocystidae	5794|Apicomplexa	U	Plug domain of Sec61p	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K10956	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.4,3.A.5.8,3.A.5.9	-	-	Plug_translocon,SecY
EH1_k127_6046952_22	368407.Memar_0586	3.99e-20	96.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2N9U7@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
EH1_k127_6046952_20	768672.Desfe_0971	7.043e-27	118.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
EH1_k127_6046952_15	1343739.PAP_01820	7.237e-36	141.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,243IZ@183968|Thermococci	183968|Thermococci	J	Ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
EH1_k127_6046952_2	453591.Igni_1276	8.936e-70	243.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
EH1_k127_6046952_8	589924.Ferp_1155	4.091e-47	181.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2463G@183980|Archaeoglobi	183980|Archaeoglobi	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
EH1_k127_6046952_16	1293048.CBMB010000004_gene2007	6.967e-33	132.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23VUR@183963|Halobacteria	183963|Halobacteria	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
EH1_k127_6046952_19	768679.TTX_1822	7.354e-28	124.0	COG1717@1|root,arCOG00781@2157|Archaea,2XQI2@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
EH1_k127_6046952_14	593750.Metfor_2639	3.046e-39	153.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,2N9KP@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
EH1_k127_6046952_6	342949.PNA2_0366	3.971e-54	192.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
EH1_k127_6046952_23	368408.Tpen_0241	9.852e-16	78.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
EH1_k127_6046952_5	391623.TERMP_00105	7.721e-56	201.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,242J0@183968|Thermococci	183968|Thermococci	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
EH1_k127_6046952_3	591019.Shell_1432	1.965e-60	217.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
EH1_k127_6046952_21	272557.APE_0358	2.274e-25	109.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
EH1_k127_6046952_11	673860.AciM339_1108	7.358e-42	157.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,3F2NF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
EH1_k127_6046952_17	273057.SSO0709	4.247e-32	128.0	COG0186@1|root,arCOG04096@2157|Archaea,2XQZ6@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
EH1_k127_6046952_26	573063.Metin_0628	4.881e-14	75.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23R70@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
EH1_k127_6046952_29	1444306.JFZC01000055_gene686	0.0002646	46.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,4HNUP@91061|Bacilli,26P11@186821|Sporolactobacillaceae	91061|Bacilli	J	Ribosomal L29 protein	rpmC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
EH1_k127_6046952_7	523850.TON_0072	2.543e-52	195.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
EH1_k127_6046952_12	195522.BD01_2153	1.954e-41	157.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,243D0@183968|Thermococci	183968|Thermococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
EH1_k127_6046952_25	572478.Vdis_2275	3.353e-15	79.0	COG1146@1|root,arCOG00959@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	korD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
EH1_k127_6046952_24	985053.VMUT_0097	2.086e-15	83.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6076720_0	861208.AGROH133_07611	4.105e-09	70.0	COG0840@1|root,COG2770@1|root,COG0840@2|Bacteria,COG2770@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,4B7BQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
EH1_k127_6077010_0	1232437.KL661953_gene2319	9.983e-112	376.0	COG1042@1|root,COG1042@2|Bacteria,1R8Q6@1224|Proteobacteria,42NR2@68525|delta/epsilon subdivisions,2WM2A@28221|Deltaproteobacteria,2MN2C@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
EH1_k127_6077010_1	868131.MSWAN_1425	1.119e-104	353.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
EH1_k127_6077010_2	453591.Igni_0442	1.17e-34	139.0	COG1759@1|root,arCOG04346@2157|Archaea,2XPSG@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
EH1_k127_6077010_3	384616.Pisl_0094	9.461e-19	89.0	COG1759@1|root,arCOG04346@2157|Archaea,2XPSG@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0043774,GO:0044424,GO:0044464	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
EH1_k127_6107315_0	883.DvMF_2992	5.347e-198	639.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
EH1_k127_6107315_6	368408.Tpen_1212	3.008e-50	186.0	COG5012@1|root,arCOG02028@2157|Archaea,2XRVB@28889|Crenarchaeota	28889|Crenarchaeota	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
EH1_k127_6107315_3	1121405.dsmv_1485	4.719e-71	257.0	arCOG05143@1|root,2Z8AM@2|Bacteria,1NZHI@1224|Proteobacteria,430YM@68525|delta/epsilon subdivisions,2WVZ9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Monomethylamine methyltransferase MtmB	-	-	2.1.1.248	ko:K16176	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09998,R10014	RC00035,RC01144,RC02985	ko00000,ko00001,ko00002,ko01000	-	-	-	MtmB
EH1_k127_6107315_5	1089553.Tph_c27670	5.4e-59	212.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548,ko:K14084	ko00270,ko00450,ko00670,ko00680,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map01100,map01110,map01120,map01200,map01230	M00017,M00563	R00946,R09124,R09365	RC00035,RC00113,RC00732,RC01241,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
EH1_k127_6107315_1	673860.AciM339_0160	1.391e-103	346.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
EH1_k127_6107315_2	633148.Tagg_0698	2.226e-98	331.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH1_k127_6107315_4	1068980.ARVW01000001_gene7387	5.883e-65	238.0	COG1173@1|root,COG1173@2|Bacteria,2GKAW@201174|Actinobacteria,4DYSP@85010|Pseudonocardiales	201174|Actinobacteria	EP	ABC-type dipeptide oligopeptide nickel transport system, permease component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH1_k127_6112144_1	1196323.ALKF01000203_gene3795	2.723e-05	54.0	COG0454@1|root,COG0456@2|Bacteria,1TS4G@1239|Firmicutes,4HFDG@91061|Bacilli,26XFQ@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_6112144_0	1343739.PAP_06030	1.21e-90	314.0	COG4690@1|root,arCOG03602@2157|Archaea,2Y1V5@28890|Euryarchaeota,2438M@183968|Thermococci	183968|Thermococci	E	Peptidase family C69	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
EH1_k127_6112144_2	326297.Sama_1277	3.852e-05	47.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,1RMFX@1236|Gammaproteobacteria,2QABF@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_437,iPC815.YPO2222,iSbBS512_1146.SbBS512_E1505,iUTI89_1310.UTI89_C1548	GTP_cyclohydro2
EH1_k127_6114236_0	1121346.KB899823_gene2325	5.773e-06	59.0	COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,4HC7R@91061|Bacilli,26S5Z@186822|Paenibacillaceae	91061|Bacilli	V	Cell division protein FtsX	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH1_k127_6115483_0	1232437.KL661978_gene3851	8.371e-267	837.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_6117345_3	203908.EGG01441	3.461e-06	59.0	COG5029@1|root,KOG0366@2759|Eukaryota,38DTQ@33154|Opisthokonta,3NTZW@4751|Fungi,3UZ5B@5204|Basidiomycota,2YCKM@29000|Pucciniomycotina	4751|Fungi	O	Prenyltransferase and squalene oxidase repeat	BET2	GO:0003674,GO:0003824,GO:0004659,GO:0004661,GO:0004663,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005968,GO:0006464,GO:0006605,GO:0006612,GO:0006807,GO:0006810,GO:0006886,GO:0006888,GO:0008104,GO:0008150,GO:0008152,GO:0008270,GO:0008318,GO:0009987,GO:0015031,GO:0015833,GO:0016192,GO:0016740,GO:0016765,GO:0017016,GO:0017137,GO:0018342,GO:0018344,GO:0019538,GO:0019899,GO:0031267,GO:0032991,GO:0033036,GO:0034613,GO:0036211,GO:0042886,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046872,GO:0046907,GO:0046914,GO:0048193,GO:0051020,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0072657,GO:0072659,GO:0090150,GO:0097354,GO:0140096,GO:1901564,GO:1902494,GO:1990234,GO:1990778	2.5.1.60	ko:K05956	-	-	-	-	ko00000,ko01000,ko01006,ko04131	-	-	-	Prenyltrans
EH1_k127_6117345_0	589924.Ferp_2549	4.299e-86	295.0	COG0492@1|root,arCOG01296@2157|Archaea,2XTJW@28890|Euryarchaeota,24639@183980|Archaeoglobi	183980|Archaeoglobi	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
EH1_k127_6117345_1	591019.Shell_1086	1.062e-21	105.0	COG4028@1|root,arCOG04328@2157|Archaea,2XQGW@28889|Crenarchaeota	28889|Crenarchaeota	S	P-loop ATPase GTPase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6117345_2	673860.AciM339_1242	6.372e-16	78.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2WH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
EH1_k127_6162870_3	269797.Mbar_A2034	4.095e-08	58.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,2NB8N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6162870_1	269797.Mbar_A1179	2.246e-77	273.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
EH1_k127_6162870_2	391623.TERMP_01792	5.493e-65	246.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,243P6@183968|Thermococci	183968|Thermococci	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT_C2
EH1_k127_6162870_0	1459636.NTE_02924	3.086e-175	581.0	COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
EH1_k127_6171342_2	1265505.ATUG01000001_gene2889	1.398e-07	61.0	COG0406@1|root,COG0406@2|Bacteria,1RD8S@1224|Proteobacteria,42RWY@68525|delta/epsilon subdivisions,2WNIA@28221|Deltaproteobacteria,2MK2F@213118|Desulfobacterales	28221|Deltaproteobacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
EH1_k127_6171342_0	439481.Aboo_0843	2.254e-62	234.0	COG1173@1|root,arCOG00748@2157|Archaea,2XVZA@28890|Euryarchaeota,3F300@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH1_k127_6171342_1	1304874.JAFY01000002_gene135	5.516e-45	171.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH1_k127_6238136_1	643648.Slip_0391	6.365e-102	342.0	COG0409@1|root,COG0409@2|Bacteria,1TPM7@1239|Firmicutes,248EX@186801|Clostridia,42KHA@68298|Syntrophomonadaceae	186801|Clostridia	O	PFAM hydrogenase formation HypD protein	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
EH1_k127_6238136_2	768670.Calni_0513	1.168e-18	94.0	COG0746@1|root,COG0746@2|Bacteria,2GFT1@200930|Deferribacteres	200930|Deferribacteres	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
EH1_k127_6238136_0	868131.MSWAN_2320	7.977e-228	722.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23NUK@183925|Methanobacteria	183925|Methanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
EH1_k127_626413_4	1461694.ATO9_09600	7.413e-16	90.0	28IVP@1|root,2Z8U1@2|Bacteria,1QWF9@1224|Proteobacteria,2UFWI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_626413_3	1078020.KEK_14828	2.947e-16	85.0	2EX84@1|root,33QIW@2|Bacteria,2ICDC@201174|Actinobacteria	201174|Actinobacteria	S	PEP-utilising enzyme, mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers
EH1_k127_626413_0	913865.DOT_2357	1.002e-53	201.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,260AR@186807|Peptococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
EH1_k127_626413_7	646529.Desaci_1060	1.141e-06	55.0	COG1146@1|root,COG1146@2|Bacteria,1W2AI@1239|Firmicutes,25709@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
EH1_k127_626413_1	880072.Desac_2119	2.41e-44	172.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria,2MRI3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH1_k127_626413_5	158500.BV97_02960	1.428e-11	73.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2TQZQ@28211|Alphaproteobacteria,2K3T3@204457|Sphingomonadales	204457|Sphingomonadales	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
EH1_k127_626413_2	649638.Trad_1166	7.423e-37	150.0	COG1030@1|root,COG1030@2|Bacteria,1WKAY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_626413_6	351160.RCIX1825	2.672e-08	55.0	COG2202@1|root,arCOG06918@2157|Archaea,2Y7UX@28890|Euryarchaeota	28890|Euryarchaeota	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_626597_3	497964.CfE428DRAFT_5514	2.443e-09	63.0	COG4733@1|root,COG4932@1|root,COG4733@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,Lectin_legB,fn3
EH1_k127_626597_2	1227484.C471_14570	2.616e-10	68.0	COG0642@1|root,COG3413@1|root,arCOG02360@1|root,arCOG02389@1|root,arCOG06712@1|root,arCOG02276@2157|Archaea,arCOG02360@2157|Archaea,arCOG02389@2157|Archaea,arCOG06219@2157|Archaea,arCOG06712@2157|Archaea,2XTCA@28890|Euryarchaeota,23S6Z@183963|Halobacteria	183963|Halobacteria	T	COG2202 FOG PAS PAC domain	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,PAS,PAS_3,PAS_4,PAS_9
EH1_k127_626597_0	351160.RCIX1700	2.943e-38	145.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXTN@28890|Euryarchaeota,2NB5F@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
EH1_k127_626597_1	1046714.AMRX01000006_gene3264	1.013e-37	152.0	2DRCH@1|root,33B7I@2|Bacteria,1NN9U@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6297271_0	1304875.JAFZ01000001_gene971	1.204e-49	199.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_6307296_4	1321786.HMPREF1992_00797	2.196e-05	47.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,4H3CG@909932|Negativicutes	909932|Negativicutes	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_6307296_0	525904.Tter_1864	3.462e-84	291.0	COG0391@1|root,COG0391@2|Bacteria,2NQGV@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0052	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
EH1_k127_6307296_2	1187851.A33M_3617	3.081e-44	168.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH1_k127_6307296_1	1145276.T479_21865	2.618e-83	294.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4HAIC@91061|Bacilli,3J049@400634|Lysinibacillus	91061|Bacilli	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	arsB_2	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	CitMHS
EH1_k127_6307296_3	304371.MCP_1286	1.19e-10	63.0	COG2202@1|root,arCOG02348@1|root,arCOG02348@2157|Archaea,arCOG06918@2157|Archaea,2Y7T3@28890|Euryarchaeota,2NBM9@224756|Methanomicrobia	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
EH1_k127_6310902_0	525146.Ddes_0443	9.626e-34	135.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2M9D1@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
EH1_k127_6310902_1	483219.LILAB_09840	2.068e-30	130.0	COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,42XHQ@68525|delta/epsilon subdivisions,2WSQA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
EH1_k127_6314280_6	292459.STH595	5.238e-16	85.0	2DR9X@1|root,33AUW@2|Bacteria	2|Bacteria	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
EH1_k127_6314280_5	350688.Clos_0569	1.671e-26	119.0	COG1526@1|root,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,36HJU@31979|Clostridiaceae	186801|Clostridia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
EH1_k127_6314280_1	264732.Moth_1996	7.495e-94	318.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42EK4@68295|Thermoanaerobacterales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
EH1_k127_6314280_0	574087.Acear_1487	1.146e-148	492.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_6314280_4	1365176.N186_08495	2.551e-28	121.0	COG1142@1|root,arCOG01502@2157|Archaea,2XR9N@28889|Crenarchaeota	28889|Crenarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_3,Fer4_4,Fer4_6,Fer4_9
EH1_k127_6314280_2	1196031.ALEG01000008_gene5059	6.1e-57	207.0	COG1878@1|root,COG1878@2|Bacteria,1UZ93@1239|Firmicutes,4IRAF@91061|Bacilli,1ZRSX@1386|Bacillus	91061|Bacilli	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
EH1_k127_6314280_3	273063.STK_10220	4.518e-34	139.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQS8@28889|Crenarchaeota	28889|Crenarchaeota	K	ASNC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
EH1_k127_6314280_7	562970.Btus_2028	9.906e-08	58.0	COG0531@1|root,COG0531@2|Bacteria,1VZMY@1239|Firmicutes,4I0B0@91061|Bacilli	91061|Bacilli	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_636232_10	533247.CRD_01668	2.906e-05	52.0	COG1721@1|root,COG1721@2|Bacteria,1G1DK@1117|Cyanobacteria,1HKYB@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
EH1_k127_636232_2	384616.Pisl_1398	8.259e-50	190.0	COG0608@1|root,arCOG00424@2157|Archaea,2XPR0@28889|Crenarchaeota	28889|Crenarchaeota	L	phosphoesterase RecJ domain protein	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
EH1_k127_636232_6	1041930.Mtc_1997	1.355e-10	75.0	COG1297@1|root,arCOG04807@2157|Archaea	2157|Archaea	S	Oligopeptide transporter OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
EH1_k127_636232_8	7213.XP_004519872.1	6.2e-10	64.0	KOG3276@1|root,KOG3276@2759|Eukaryota,3A5MU@33154|Opisthokonta,3BSI1@33208|Metazoa,3D9EH@33213|Bilateria,420JZ@6656|Arthropoda,3SNQN@50557|Insecta,453YX@7147|Diptera	33208|Metazoa	S	DUF167	C15orf40	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
EH1_k127_636232_5	1396418.BATQ01000104_gene5481	4.837e-24	112.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_636232_9	1288484.APCS01000119_gene779	7.964e-09	66.0	COG0500@1|root,COG2226@2|Bacteria,1WIUM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
EH1_k127_636232_0	186497.PF2002	5.224e-81	287.0	arCOG00137@1|root,arCOG00137@2157|Archaea,2Y2A4@28890|Euryarchaeota,242R8@183968|Thermococci	183968|Thermococci	G	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_636232_1	673860.AciM339_0586	2.012e-57	215.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y726@28890|Euryarchaeota,3F38D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K19576	-	-	-	-	ko00000,ko02000	2.A.1.2.10	-	-	MFS_1
EH1_k127_636232_11	1077972.ARGLB_058_00260	6.285e-05	51.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,1W9SI@1268|Micrococcaceae	201174|Actinobacteria	OU	NfeD-like C-terminal, partner-binding	nfeD	-	-	-	-	-	-	-	-	-	-	-	NfeD
EH1_k127_636232_4	456442.Mboo_0647	6.241e-25	109.0	COG4741@1|root,arCOG05252@2157|Archaea	2157|Archaea	F	related to archaeal Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
EH1_k127_636232_7	1449044.JMLE01000028_gene261	2.194e-10	67.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_3,Flavodoxin_5
EH1_k127_636232_3	485918.Cpin_2593	2.503e-30	138.0	COG1470@1|root,COG1470@2|Bacteria,4P0GS@976|Bacteroidetes	976|Bacteroidetes	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6392956_1	243231.GSU0990	1.996e-06	61.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Haemagg_act,TIG
EH1_k127_6392956_0	161934.XP_010696355.1	4.453e-99	344.0	COG1697@1|root,KOG2795@2759|Eukaryota,37QGK@33090|Viridiplantae,3G85Y@35493|Streptophyta	35493|Streptophyta	L	Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity	TOP6A	GO:0000003,GO:0000228,GO:0000280,GO:0000706,GO:0000729,GO:0001708,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008094,GO:0008150,GO:0008152,GO:0008544,GO:0009888,GO:0009913,GO:0009957,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0022402,GO:0022414,GO:0030154,GO:0030855,GO:0031974,GO:0031981,GO:0032502,GO:0033554,GO:0034641,GO:0035825,GO:0042138,GO:0042623,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045165,GO:0046483,GO:0048285,GO:0048856,GO:0048869,GO:0050896,GO:0051321,GO:0051716,GO:0060429,GO:0061505,GO:0061982,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140013,GO:0140097,GO:1901360,GO:1901363,GO:1903046	-	ko:K10878	ko04113,map04113	-	-	-	ko00000,ko00001,ko03400	-	-	-	TP6A_N
EH1_k127_6397113_2	69014.TK0142	1.954e-05	53.0	COG2247@1|root,arCOG00395@2157|Archaea,2XV3M@28890|Euryarchaeota,243T4@183968|Thermococci	183968|Thermococci	K	cell wall organization	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,HTH_24
EH1_k127_6397113_0	525904.Tter_0762	3.257e-55	200.0	COG0177@1|root,COG0177@2|Bacteria,2NP8N@2323|unclassified Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
EH1_k127_6397113_3	1125863.JAFN01000001_gene1810	0.0005921	45.0	COG0426@1|root,COG0426@2|Bacteria,1N47N@1224|Proteobacteria,42UNB@68525|delta/epsilon subdivisions,2WQA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
EH1_k127_6405951_0	269797.Mbar_A2330	3.554e-43	167.0	COG0500@1|root,arCOG01773@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH1_k127_6405951_1	880071.Fleli_3427	2.63e-09	67.0	2EIVC@1|root,33CKQ@2|Bacteria,4NY8R@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6405951_2	1453505.JASY01000002_gene2660	7.992e-07	60.0	COG0546@1|root,COG0546@2|Bacteria,4NPRI@976|Bacteroidetes,1I2QU@117743|Flavobacteriia,2NTEN@237|Flavobacterium	976|Bacteroidetes	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
EH1_k127_6405951_3	1469607.KK073768_gene4518	7.549e-05	48.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1HIQE@1161|Nostocales	1117|Cyanobacteria	K	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
EH1_k127_6429869_1	391623.TERMP_01742	2.038e-13	76.0	COG4143@1|root,arCOG00226@2157|Archaea,2XT44@28890|Euryarchaeota,24311@183968|Thermococci	183968|Thermococci	H	ABC-type thiamine transport system, periplasmic component	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
EH1_k127_6429869_0	1227457.C451_15005	5.904e-32	136.0	COG1992@1|root,arCOG00021@2157|Archaea,2XTP7@28890|Euryarchaeota,23SNG@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN2	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
EH1_k127_6460757_6	263815.XP_007873148.1	7.664e-07	59.0	KOG4068@1|root,KOG4068@2759|Eukaryota,39S7B@33154|Opisthokonta,3P2R4@4751|Fungi,3QWVJ@4890|Ascomycota,3MCY0@451866|Taphrinomycotina	4751|Fungi	U	ESCRT II complex subunit Vps25	-	GO:0000429,GO:0000430,GO:0000433,GO:0000814,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005829,GO:0006355,GO:0006357,GO:0006508,GO:0006511,GO:0006605,GO:0006623,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006862,GO:0006886,GO:0007034,GO:0007154,GO:0007584,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010008,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0012505,GO:0015031,GO:0015711,GO:0015748,GO:0015833,GO:0015865,GO:0015867,GO:0015868,GO:0015893,GO:0015931,GO:0016020,GO:0016192,GO:0016197,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0030163,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031982,GO:0032509,GO:0032511,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036452,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0042886,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043328,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045013,GO:0045014,GO:0045184,GO:0045324,GO:0045892,GO:0045934,GO:0045990,GO:0046015,GO:0046618,GO:0046907,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051503,GO:0051603,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0061986,GO:0061987,GO:0065007,GO:0070727,GO:0070887,GO:0071496,GO:0071702,GO:0071704,GO:0071705,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0097708,GO:0098588,GO:0098796,GO:0098805,GO:1901264,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:1904669,GO:2000112,GO:2000113,GO:2001141	-	ko:K12189	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	ESCRT-II
EH1_k127_6460757_4	7668.SPU_021774-tr	2.503e-15	85.0	KOG3341@1|root,KOG3341@2759|Eukaryota,38FCZ@33154|Opisthokonta,3B9KQ@33208|Metazoa,3CUGF@33213|Bilateria	33208|Metazoa	U	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs	SNF8	GO:0000003,GO:0000578,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031326,GO:0031410,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045921,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:1903506,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:2000112,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
EH1_k127_6460757_0	1343739.PAP_09115	1.692e-129	429.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,242Q1@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K22503	ko00970,map00970	M00359	R05577	RC00055,RC00523	ko00000,ko00001,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
EH1_k127_6460757_5	1114856.C496_23191	8.757e-09	61.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
EH1_k127_6460757_1	865861.AZSU01000002_gene2618	5.971e-115	385.0	COG0863@1|root,COG0863@2|Bacteria,1TPR7@1239|Firmicutes,24A3P@186801|Clostridia,36E8V@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
EH1_k127_6460757_3	234267.Acid_2435	9.976e-77	274.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH1_k127_6460757_2	415426.Hbut_1274	6.127e-90	306.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
EH1_k127_646287_3	267377.MMP0634	1.204e-06	58.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23QAJ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH1_k127_646287_1	1343739.PAP_00920	2.873e-60	220.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,244E3@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH1_k127_646287_0	589924.Ferp_1018	1.122e-79	276.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,24626@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( )	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
EH1_k127_646287_2	221360.RS9917_12075	1.095e-19	96.0	COG0673@1|root,COG0673@2|Bacteria,1G18K@1117|Cyanobacteria,1GYUA@1129|Synechococcus	1117|Cyanobacteria	S	Oxidoreductase	mviM	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
EH1_k127_6467182_1	224325.AF_0534	2.173e-35	141.0	COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,246G2@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_6467182_0	644282.Deba_1706	1.492e-87	300.0	COG2006@1|root,COG2006@2|Bacteria,1R6CE@1224|Proteobacteria,42QI7@68525|delta/epsilon subdivisions,2WJA0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
EH1_k127_6471731_0	439481.Aboo_0423	2.213e-49	184.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2Y8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH1_k127_6554764_0	1210908.HSB1_12600	3.126e-44	172.0	COG1266@1|root,arCOG02768@2157|Archaea,2XYFG@28890|Euryarchaeota,23WID@183963|Halobacteria	183963|Halobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
EH1_k127_6554764_2	765420.OSCT_2237	1.434e-30	133.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_6554764_1	388399.SSE37_16088	2.597e-39	154.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
EH1_k127_6568385_2	370438.PTH_2884	3.444e-46	172.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,2613P@186807|Peptococcaceae	186801|Clostridia	S	FAD-dependent	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
EH1_k127_6568385_0	401526.TcarDRAFT_1351	5.611e-73	253.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,4H2YJ@909932|Negativicutes	909932|Negativicutes	S	FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,GIDA,HI0933_like,Lycopene_cycl,Pyr_redox_2
EH1_k127_6568385_1	391623.TERMP_01274	1.277e-58	211.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,242KT@183968|Thermococci	183968|Thermococci	D	Cell division protein 48 (CDC48) N-terminal domain	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
EH1_k127_6576566_1	374847.Kcr_0806	1.762e-46	178.0	arCOG06048@1|root,arCOG06048@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6576566_0	765177.Desmu_0548	1.345e-76	267.0	COG2129@1|root,arCOG01145@2157|Archaea,2XQCA@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos
EH1_k127_6576566_2	374847.Kcr_0332	4.097e-06	57.0	arCOG03462@1|root,arCOG03462@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
EH1_k127_6596732_2	1459636.NTE_00846	3.241e-23	112.0	COG1994@1|root,COG3582@1|root,arCOG00614@2157|Archaea,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
EH1_k127_6596732_0	56780.SYN_02526	7.621e-112	372.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,42SXH@68525|delta/epsilon subdivisions,2WP5D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.338	ko:K16844	ko00270,ko01120,map00270,map01120	-	R07137	RC00031	ko00000,ko00001,ko01000	-	-	-	Ldh_2
EH1_k127_6596732_1	373903.Hore_13850	7.217e-44	164.0	COG1573@1|root,COG1573@2|Bacteria,1V1SU@1239|Firmicutes,24E7B@186801|Clostridia	186801|Clostridia	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
EH1_k127_6603184_1	1192034.CAP_6745	3.788e-61	215.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	-	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
EH1_k127_6603184_0	1094980.Mpsy_1310	6.595e-70	249.0	COG1035@1|root,COG3350@1|root,arCOG02650@2157|Archaea,arCOG04507@2157|Archaea,2Y7JA@28890|Euryarchaeota,2NAMA@224756|Methanomicrobia	224756|Methanomicrobia	C	YHS domain	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	FrhB_FdhB_C,FrhB_FdhB_N,YHS
EH1_k127_6603184_2	429009.Adeg_0940	6.554e-26	114.0	COG1618@1|root,COG1618@2|Bacteria,1VE8K@1239|Firmicutes,24Q8Z@186801|Clostridia,42IED@68295|Thermoanaerobacterales	186801|Clostridia	F	NTPase	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
EH1_k127_6620429_6	638303.Thal_0887	9.121e-26	110.0	COG1324@1|root,COG1324@2|Bacteria,2G58I@200783|Aquificae	200783|Aquificae	P	CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
EH1_k127_6620429_1	1041930.Mtc_0466	5.99e-63	235.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
EH1_k127_6620429_4	1131269.AQVV01000016_gene1859	8.493e-53	205.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
EH1_k127_6620429_2	1444309.JAQG01000017_gene735	7.302e-59	219.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,26VZV@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase family M28	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
EH1_k127_6620429_3	1459636.NTE_02799	6.38e-56	205.0	COG1691@1|root,arCOG02465@2157|Archaea,41SCY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
EH1_k127_6620429_5	1042877.GQS_06615	2.59e-40	159.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,243PB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
EH1_k127_6620429_0	339860.Msp_1301	1.058e-78	281.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
EH1_k127_6620429_7	946362.XP_004997129.1	4.665e-14	79.0	COG1100@1|root,KOG0072@2759|Eukaryota,38G98@33154|Opisthokonta	33154|Opisthokonta	U	activation of phospholipase D activity	ARL1	GO:0000045,GO:0000139,GO:0000166,GO:0001505,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006403,GO:0006605,GO:0006623,GO:0006810,GO:0006836,GO:0006886,GO:0006892,GO:0006893,GO:0006897,GO:0006914,GO:0006950,GO:0006996,GO:0007029,GO:0007030,GO:0007033,GO:0007034,GO:0007154,GO:0007267,GO:0007268,GO:0007269,GO:0007275,GO:0007431,GO:0007444,GO:0008047,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009888,GO:0009987,GO:0010256,GO:0010517,GO:0010518,GO:0012505,GO:0015031,GO:0015833,GO:0015931,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016462,GO:0016482,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019748,GO:0019904,GO:0022607,GO:0023052,GO:0023061,GO:0030234,GO:0030334,GO:0031090,GO:0031503,GO:0031584,GO:0031984,GO:0032258,GO:0032386,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032588,GO:0032879,GO:0032880,GO:0032940,GO:0033036,GO:0033157,GO:0033227,GO:0033363,GO:0033365,GO:0033554,GO:0034067,GO:0034497,GO:0034613,GO:0034629,GO:0034976,GO:0035220,GO:0035272,GO:0035295,GO:0035639,GO:0036094,GO:0036465,GO:0040012,GO:0042147,GO:0042886,GO:0043001,GO:0043085,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044093,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0048193,GO:0048488,GO:0048513,GO:0048731,GO:0048732,GO:0048856,GO:0050657,GO:0050658,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051223,GO:0051234,GO:0051236,GO:0051270,GO:0051336,GO:0051345,GO:0051641,GO:0051649,GO:0051716,GO:0060191,GO:0060193,GO:0060341,GO:0060429,GO:0060627,GO:0060628,GO:0061024,GO:0061919,GO:0061951,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070727,GO:0070861,GO:0070925,GO:0071702,GO:0071705,GO:0071840,GO:0072594,GO:0072657,GO:0072659,GO:0072665,GO:0072666,GO:0090087,GO:0090150,GO:0090158,GO:0097159,GO:0097367,GO:0098588,GO:0098657,GO:0098772,GO:0098791,GO:0098876,GO:0098916,GO:0099003,GO:0099504,GO:0099536,GO:0099537,GO:0099643,GO:1901265,GO:1901363,GO:1903292,GO:1903827,GO:1905037,GO:1990778,GO:2000145	-	ko:K07942	-	-	-	-	ko00000,ko04031,ko04131	-	-	-	Arf
EH1_k127_6675884_1	195522.BD01_0479	9.992e-20	104.0	arCOG07561@1|root,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota,2435K@183968|Thermococci	183968|Thermococci	K	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
EH1_k127_6675884_0	1094980.Mpsy_3151	5.008e-36	157.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6675884_2	748727.CLJU_c37230	0.0004185	44.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,36DTH@31979|Clostridiaceae	186801|Clostridia	L	8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
EH1_k127_6703310_0	246194.CHY_0689	1.311e-162	531.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,42ETM@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
EH1_k127_6703310_2	1382306.JNIM01000001_gene2072	2.556e-39	157.0	arCOG06048@1|root,31EJQ@2|Bacteria,2G6TM@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6703310_1	374847.Kcr_0805	4.3e-73	257.0	COG2129@1|root,arCOG01145@2157|Archaea	2157|Archaea	P	PFAM Metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_3
EH1_k127_6703310_3	383372.Rcas_0129	4.477e-25	118.0	COG0531@1|root,COG0531@2|Bacteria,2G76Z@200795|Chloroflexi	200795|Chloroflexi	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
EH1_k127_6725555_4	710686.Mycsm_00254	1.015e-10	74.0	COG0477@1|root,COG0477@2|Bacteria,2HC9X@201174|Actinobacteria,235S8@1762|Mycobacteriaceae	201174|Actinobacteria	EGP	Transporter	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	Sugar_tr
EH1_k127_6725555_2	1151117.AJLF01000001_gene1487	1.652e-17	93.0	COG0697@1|root,arCOG00272@2157|Archaea,2XZ49@28890|Euryarchaeota,242N7@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
EH1_k127_6725555_3	1220534.B655_0937	4.891e-17	85.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3,zinc_ribbon_2
EH1_k127_6725555_0	1220534.B655_0941	1.654e-184	588.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
EH1_k127_6740516_1	68170.KL590490_gene1264	1.258e-29	140.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
EH1_k127_6740516_0	68170.KL590490_gene1267	3.49e-36	162.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
EH1_k127_676978_1	368408.Tpen_0332	7.902e-19	96.0	arCOG03119@1|root,arCOG03119@2157|Archaea,2XQUD@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
EH1_k127_676978_0	269797.Mbar_A3720	5.336e-23	112.0	COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota,2N9Q8@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
EH1_k127_6793767_0	694429.Pyrfu_0913	2.361e-60	216.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
EH1_k127_6793767_1	1232437.KL662016_gene998	2.392e-06	58.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria,2MHYA@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3,Sugar_tr
EH1_k127_6796441_3	1242864.D187_001517	3.401e-79	278.0	COG1032@1|root,COG1032@2|Bacteria,1RF63@1224|Proteobacteria,42S8Y@68525|delta/epsilon subdivisions,2WNX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
EH1_k127_6796441_2	694429.Pyrfu_0840	2.028e-83	287.0	COG0731@1|root,arCOG04174@2157|Archaea,2XPM3@28889|Crenarchaeota	28889|Crenarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
EH1_k127_6796441_9	552811.Dehly_0767	1.352e-36	146.0	COG2178@1|root,COG2178@2|Bacteria,2G6RW@200795|Chloroflexi,34CS2@301297|Dehalococcoidia	301297|Dehalococcoidia	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
EH1_k127_6796441_8	1183377.Py04_1099	1.532e-38	153.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,242U9@183968|Thermococci	183968|Thermococci	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,HTH_27,HTH_Crp_2,MarR_2
EH1_k127_6796441_4	694429.Pyrfu_0108	1.425e-65	233.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
EH1_k127_6796441_13	589924.Ferp_1275	1.802e-22	105.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,246DZ@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
EH1_k127_6796441_5	868131.MSWAN_1563	1.102e-59	220.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,23NUJ@183925|Methanobacteria	183925|Methanobacteria	J	N2,N2-dimethylguanosine tRNA methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
EH1_k127_6796441_10	386456.JQKN01000016_gene901	4.263e-27	124.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
EH1_k127_6796441_14	1094508.Tsac_0594	2.225e-22	110.0	COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes,24IX5@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
EH1_k127_6796441_19	1437824.BN940_14136	2.603e-07	63.0	28IIF@1|root,2Z8JJ@2|Bacteria,1NUA0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	4.2.1.127,5.4.4.4	ko:K20614	-	-	-	-	ko00000,ko01000	-	-	-	-
EH1_k127_6796441_7	765913.ThidrDRAFT_1391	7.592e-44	175.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,1SM1V@1236|Gammaproteobacteria,1X00A@135613|Chromatiales	135613|Chromatiales	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
EH1_k127_6796441_6	237368.SCABRO_02465	4.816e-53	194.0	COG1136@1|root,COG1136@2|Bacteria,2J1VY@203682|Planctomycetes	203682|Planctomycetes	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
EH1_k127_6796441_17	944546.ABED_1908	2.167e-10	72.0	28K4S@1|root,2Z9TM@2|Bacteria,1N4AQ@1224|Proteobacteria,42PSN@68525|delta/epsilon subdivisions,2YMP7@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6796441_18	1499683.CCFF01000012_gene1285	8.492e-08	63.0	COG4449@1|root,COG4449@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abi
EH1_k127_6796441_15	647113.Metok_1476	8.626e-20	93.0	COG0375@1|root,arCOG04426@2157|Archaea,2XY46@28890|Euryarchaeota,23QZX@183939|Methanococci	183939|Methanococci	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
EH1_k127_6796441_20	330214.NIDE1286	3.416e-05	54.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
EH1_k127_6796441_11	797299.HALLA_15405	2.335e-26	112.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23W98@183963|Halobacteria	183963|Halobacteria	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
EH1_k127_6796441_1	1220534.B655_2351	1.414e-100	342.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,23NWV@183925|Methanobacteria	183925|Methanobacteria	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
EH1_k127_6796441_12	269797.Mbar_A0594	3.329e-25	111.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
EH1_k127_6796441_16	529709.PYCH_01210	1.306e-16	89.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2434N@183968|Thermococci	183968|Thermococci	L	Segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
EH1_k127_6796441_0	529709.PYCH_01200	2.209e-101	361.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
EH1_k127_6803067_21	643867.Ftrac_2288	6.913e-23	106.0	COG2020@1|root,COG2020@2|Bacteria,4NTXI@976|Bacteroidetes,47RFP@768503|Cytophagia	976|Bacteroidetes	O	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
EH1_k127_6803067_19	1365176.N186_01240	5.284e-28	119.0	arCOG00299@1|root,arCOG00299@2157|Archaea,2XQKR@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6803067_22	797304.Natgr_1172	3.355e-21	105.0	COG3608@1|root,arCOG02890@2157|Archaea,2XUN3@28890|Euryarchaeota,23TXV@183963|Halobacteria	183963|Halobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
EH1_k127_6803067_28	509191.AEDB02000098_gene3518	0.0001622	51.0	2AV9C@1|root,31M09@2|Bacteria,1UFS2@1239|Firmicutes,24W59@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6803067_10	1183377.Py04_0876	6.284e-66	235.0	COG2521@1|root,arCOG00054@2157|Archaea,2Y2KZ@28890|Euryarchaeota,243QH@183968|Thermococci	183968|Thermococci	Q	Spermine/spermidine synthase domain	-	-	-	ko:K06983	-	-	-	-	ko00000	-	-	-	Methyltransf_11,Methyltransf_25
EH1_k127_6803067_27	1280689.AUJC01000001_gene2348	2.609e-06	59.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,36JIM@31979|Clostridiaceae	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
EH1_k127_6803067_4	926550.CLDAP_21080	7.029e-135	441.0	COG0474@1|root,COG0474@2|Bacteria,2G60Z@200795|Chloroflexi	200795|Chloroflexi	P	Cation transporting ATPase, C-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH1_k127_6803067_0	673860.AciM339_1034	8.008e-280	890.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,3F2EY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
EH1_k127_6803067_23	521011.Mpal_0795	4.018e-13	73.0	arCOG08221@1|root,arCOG08221@2157|Archaea,2Y1Z0@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6803067_5	243232.MJ_1192	5.506e-125	419.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,23QHR@183939|Methanococci	183939|Methanococci	C	PFAM Nickel-dependent hydrogenase, large subunit	vhuA	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
EH1_k127_6803067_9	647113.Metok_0822	9.686e-68	241.0	COG1941@1|root,arCOG02472@2157|Archaea,2XVJ0@28890|Euryarchaeota,23QEJ@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	vhuG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
EH1_k127_6803067_14	429009.Adeg_2015	2e-50	184.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
EH1_k127_6803067_25	1365176.N186_03445	2.815e-08	59.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH1_k127_6803067_1	574087.Acear_1487	1.619e-148	491.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_6803067_20	565033.GACE_0774	5.12e-25	110.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
EH1_k127_6803067_8	748727.CLJU_c15340	4.304e-87	306.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	-	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
EH1_k127_6803067_24	272844.PAB3241	6.481e-13	76.0	COG1977@1|root,arCOG00536@2157|Archaea,2Y6GG@28890|Euryarchaeota,244HE@183968|Thermococci	183968|Thermococci	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
EH1_k127_6803067_18	702438.HMPREF9431_01429	1.469e-30	132.0	COG0524@1|root,COG0524@2|Bacteria,4NFJ9@976|Bacteroidetes,2FM38@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
EH1_k127_6803067_16	1041930.Mtc_2101	3.602e-42	169.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
EH1_k127_6803067_6	1184251.TCELL_1373	1.341e-104	351.0	COG0167@1|root,COG1143@1|root,arCOG00603@2157|Archaea,arCOG01543@2157|Archaea,2XQ06@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
EH1_k127_6803067_3	574087.Acear_1487	2.851e-136	456.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_6803067_17	589924.Ferp_1231	8.8e-39	152.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
EH1_k127_6803067_2	485913.Krac_6352	3.725e-137	450.0	COG0402@1|root,COG0402@2|Bacteria,2G6DG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,CYTH
EH1_k127_6803067_11	1499967.BAYZ01000156_gene556	6.925e-65	229.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
EH1_k127_6803067_26	453591.Igni_1084	1.25e-07	64.0	COG1668@1|root,arCOG01462@2157|Archaea,2XPNJ@28889|Crenarchaeota	28889|Crenarchaeota	C	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
EH1_k127_6803067_12	351160.RRC81	3.477e-62	222.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH1_k127_6803067_13	374847.Kcr_0737	8.648e-59	216.0	COG0476@1|root,arCOG01676@2157|Archaea	2157|Archaea	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	TBP,ThiF,ThiS
EH1_k127_6803067_15	186497.PF0703	2.2e-48	182.0	arCOG04883@1|root,arCOG04883@2157|Archaea,2Y2KG@28890|Euryarchaeota,245FR@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6803067_7	272844.PAB0829	1.668e-91	315.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
EH1_k127_6805975_0	36331.EPrPI00000015031	1.737e-38	158.0	KOG4341@1|root,KOG4341@2759|Eukaryota,1MD7A@121069|Pythiales	121069|Pythiales	L	Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	DUF389,IQ,LRR_6
EH1_k127_6805975_7	644076.SCH4B_3800	0.0001122	52.0	COG0640@1|root,COG0640@2|Bacteria,1N3ZI@1224|Proteobacteria,2UCYW@28211|Alphaproteobacteria,4NDJU@97050|Ruegeria	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
EH1_k127_6805975_2	370438.PTH_1831	1.227e-29	125.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
EH1_k127_6805975_3	1094980.Mpsy_2342	2.187e-23	114.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
EH1_k127_6805975_6	1306990.BARG01000110_gene9868	8.441e-08	65.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
EH1_k127_6805975_1	633148.Tagg_1188	7.593e-33	138.0	COG0467@1|root,arCOG01171@2157|Archaea,2XPNC@28889|Crenarchaeota	28889|Crenarchaeota	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
EH1_k127_6805975_5	269800.Tfu_1181	7.836e-11	68.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4EH2P@85012|Streptosporangiales	201174|Actinobacteria	T	ANTAR	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
EH1_k127_6805975_4	351160.RCIX1840	5.705e-23	103.0	COG0784@1|root,arCOG02391@2157|Archaea,2Y6EC@28890|Euryarchaeota,2NBEQ@224756|Methanomicrobia	224756|Methanomicrobia	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
EH1_k127_6813915_0	479434.Sthe_0670	2.815e-24	117.0	COG0477@1|root,COG2814@2|Bacteria,2G9Z5@200795|Chloroflexi,27XES@189775|Thermomicrobia	189775|Thermomicrobia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_6832697_2	267608.RSp1626	2.308e-08	63.0	COG0454@1|root,COG0454@2|Bacteria,1QUS5@1224|Proteobacteria,2WHD7@28216|Betaproteobacteria,1K8NG@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
EH1_k127_6832697_0	870187.Thini_4526	1.895e-57	222.0	COG3950@1|root,COG3950@2|Bacteria,1MUE9@1224|Proteobacteria,1RRPV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
EH1_k127_6832697_1	1163617.SCD_n00128	7.666e-27	113.0	COG1403@1|root,COG1403@2|Bacteria,1NHCP@1224|Proteobacteria	1224|Proteobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
EH1_k127_6847154_0	644966.Tmar_2146	7.174e-68	238.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,3WD79@538999|Clostridiales incertae sedis	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH1_k127_6847154_1	1120971.AUCA01000003_gene1434	5.551e-13	81.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,1TRF1@1239|Firmicutes,4HI50@91061|Bacilli	91061|Bacilli	V	COG0842 ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
EH1_k127_6862684_6	765420.OSCT_1333	4.95e-21	103.0	COG1721@1|root,COG1721@2|Bacteria,2G7PU@200795|Chloroflexi,375DS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
EH1_k127_6862684_1	195522.BD01_1777	3.443e-101	339.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,24353@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
EH1_k127_6862684_7	1324957.K933_00632	4.883e-13	81.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
EH1_k127_6862684_9	1457250.BBMO01000001_gene75	8.921e-10	74.0	COG1305@1|root,arCOG02486@2157|Archaea,2Y7XM@28890|Euryarchaeota,240Z9@183963|Halobacteria	183963|Halobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
EH1_k127_6862684_3	69014.TK0480	1.693e-41	161.0	COG1418@1|root,arCOG01860@2157|Archaea,2XT54@28890|Euryarchaeota,24358@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
EH1_k127_6862684_4	1343739.PAP_08350	1.119e-30	128.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,2440H@183968|Thermococci	183968|Thermococci	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
EH1_k127_6862684_0	633148.Tagg_0552	4.864e-106	358.0	COG0498@1|root,arCOG01434@2157|Archaea,2XQ1A@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH1_k127_6862684_2	273063.STK_02990	6.388e-80	280.0	COG0144@1|root,arCOG00973@2157|Archaea,2XQ6R@28889|Crenarchaeota	28889|Crenarchaeota	J	NOL1 NOP2 sun family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
EH1_k127_6862684_8	572546.Arcpr_0562	1.743e-11	72.0	COG1374@1|root,arCOG00993@2157|Archaea,2Y0D1@28890|Euryarchaeota,2474B@183980|Archaeoglobi	183980|Archaeoglobi	J	PUA domain	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
EH1_k127_6862684_5	768679.TTX_1935	1.218e-30	130.0	COG1938@1|root,arCOG00347@2157|Archaea,2XPV9@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
EH1_k127_6921925_8	591019.Shell_1588	2.782e-07	59.0	COG2517@1|root,arCOG04359@2157|Archaea,2XR9E@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM t-RNA-binding domain protein	-	-	-	ko:K07135	-	-	-	-	ko00000	-	-	-	tRNA_bind
EH1_k127_6921925_7	273075.Ta1201	1.934e-21	104.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,241Q6@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
EH1_k127_6921925_5	1122917.KB899679_gene451	4.425e-41	161.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,26RCQ@186822|Paenibacillaceae	91061|Bacilli	L	Hydrolase, tatd	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
EH1_k127_6921925_4	572546.Arcpr_0344	5.318e-50	195.0	COG0144@1|root,arCOG00974@2157|Archaea,2XSWG@28890|Euryarchaeota,245SS@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
EH1_k127_6921925_3	547163.BN979_04068	1.771e-51	203.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,232XE@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
EH1_k127_6921925_9	641491.DND132_0447	1.44e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,2MCBQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
EH1_k127_6921925_1	997296.PB1_08792	3.426e-72	258.0	COG2516@1|root,COG2516@2|Bacteria,1UI8Q@1239|Firmicutes,4HV1D@91061|Bacilli,1ZJTY@1386|Bacillus	91061|Bacilli	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH1_k127_6921925_2	565033.GACE_1903	2.477e-68	247.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
EH1_k127_6921925_0	278957.ABEA03000186_gene1540	8.859e-109	368.0	COG0277@1|root,COG0277@2|Bacteria,46Y87@74201|Verrucomicrobia,3K93M@414999|Opitutae	414999|Opitutae	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_6921925_6	877455.Metbo_0664	2.634e-31	138.0	COG0247@1|root,COG0479@1|root,arCOG00333@2157|Archaea,arCOG00963@2157|Archaea,2Y85M@28890|Euryarchaeota,23NVI@183925|Methanobacteria	183925|Methanobacteria	C	fumarate reductase	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
EH1_k127_6964957_1	909663.KI867150_gene2279	9.975e-94	319.0	COG0037@1|root,COG0037@2|Bacteria,1NKHX@1224|Proteobacteria,42Q26@68525|delta/epsilon subdivisions,2WPER@28221|Deltaproteobacteria,2MSF2@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	TIGRFAM N-acetyl sugar amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_6964957_0	909663.KI867150_gene1592	1.205e-95	323.0	COG0171@1|root,COG0171@2|Bacteria,1QHZ4@1224|Proteobacteria,42QD8@68525|delta/epsilon subdivisions,2WMK9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
EH1_k127_6964957_2	768671.ThimaDRAFT_1981	2.641e-18	88.0	COG0236@1|root,COG0236@2|Bacteria,1NC80@1224|Proteobacteria,1SJ0G@1236|Gammaproteobacteria,1X1K5@135613|Chromatiales	135613|Chromatiales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
EH1_k127_7031811_2	670487.Ocepr_1544	7.97e-08	61.0	COG0457@1|root,COG0457@2|Bacteria,1WJSM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
EH1_k127_7031811_1	1200792.AKYF01000019_gene4521	7.604e-10	69.0	COG0491@1|root,COG0491@2|Bacteria,1TR4H@1239|Firmicutes,4HBXR@91061|Bacilli	91061|Bacilli	F	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_7031811_0	1459636.NTE_01295	7.284e-34	134.0	COG1415@1|root,arCOG04253@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
EH1_k127_7045894_2	697281.Mahau_1079	6.725e-27	119.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,42G5Q@68295|Thermoanaerobacterales	186801|Clostridia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
EH1_k127_7045894_0	1094980.Mpsy_2726	1.134e-68	241.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
EH1_k127_7045894_1	671065.MetMK1DRAFT_00012040	8.562e-51	192.0	COG0189@1|root,arCOG01589@2157|Archaea,2XQGE@28889|Crenarchaeota	28889|Crenarchaeota	H	RimK domain protein ATP-grasp	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
EH1_k127_7045894_3	1459636.NTE_01466	9.225e-14	79.0	arCOG03727@1|root,arCOG03727@2157|Archaea,41STD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
EH1_k127_7072553_0	304371.MCP_0498	3.126e-55	200.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2N9Y8@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
EH1_k127_7072553_3	552811.Dehly_1549	3.02e-06	52.0	COG3316@1|root,COG3316@2|Bacteria,2G9P3@200795|Chloroflexi	200795|Chloroflexi	L	COGs COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
EH1_k127_7072553_1	477974.Daud_0504	1.495e-16	81.0	COG1190@1|root,COG1190@2|Bacteria	2|Bacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
EH1_k127_7072553_2	673860.AciM339_0078	6.845e-14	74.0	COG3609@1|root,arCOG06966@2157|Archaea,2Y5GZ@28890|Euryarchaeota,3F3D2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Ribbon-helix-helix protein, copG family	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	RHH_1
EH1_k127_7073389_2	126957.SMAR010035-PA	9.824e-30	125.0	KOG0078@1|root,KOG0078@2759|Eukaryota,38EHU@33154|Opisthokonta,3B9UK@33208|Metazoa,3CTWJ@33213|Bilateria,41WVY@6656|Arthropoda	33208|Metazoa	U	GTP binding. It is involved in the biological process described with protein transport	RAB10	GO:0000003,GO:0000166,GO:0000902,GO:0000904,GO:0001738,GO:0001775,GO:0001881,GO:0001882,GO:0001883,GO:0002009,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0002790,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005797,GO:0005802,GO:0005829,GO:0005886,GO:0005929,GO:0006810,GO:0006886,GO:0006887,GO:0006892,GO:0006893,GO:0006904,GO:0006955,GO:0006996,GO:0007029,GO:0007154,GO:0007163,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007295,GO:0007399,GO:0007405,GO:0007409,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008283,GO:0008356,GO:0009306,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010008,GO:0010033,GO:0010243,GO:0010256,GO:0010511,GO:0010512,GO:0010563,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016328,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017022,GO:0017076,GO:0017111,GO:0017145,GO:0017157,GO:0019001,GO:0019003,GO:0019216,GO:0019220,GO:0019222,GO:0019882,GO:0019904,GO:0019953,GO:0022008,GO:0022406,GO:0022412,GO:0022414,GO:0023051,GO:0023052,GO:0030010,GO:0030030,GO:0030133,GO:0030141,GO:0030154,GO:0030182,GO:0030198,GO:0030424,GO:0030659,GO:0030667,GO:0030855,GO:0030859,GO:0031045,GO:0031090,GO:0031175,GO:0031254,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031489,GO:0031982,GO:0031984,GO:0031985,GO:0032456,GO:0032482,GO:0032501,GO:0032502,GO:0032504,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032593,GO:0032794,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032990,GO:0033036,GO:0033365,GO:0034613,GO:0035556,GO:0035639,GO:0036094,GO:0036230,GO:0036445,GO:0036477,GO:0040007,GO:0042119,GO:0042175,GO:0042221,GO:0042886,GO:0042995,GO:0043001,GO:0043005,GO:0043025,GO:0043062,GO:0043112,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043299,GO:0043312,GO:0043434,GO:0044237,GO:0044260,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044432,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045055,GO:0045165,GO:0045175,GO:0045178,GO:0045184,GO:0045196,GO:0045200,GO:0045321,GO:0045833,GO:0045936,GO:0046677,GO:0046890,GO:0046903,GO:0046907,GO:0048103,GO:0048193,GO:0048278,GO:0048468,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048523,GO:0048589,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048729,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051021,GO:0051046,GO:0051049,GO:0051055,GO:0051128,GO:0051174,GO:0051179,GO:0051234,GO:0051301,GO:0051640,GO:0051641,GO:0051649,GO:0051704,GO:0051716,GO:0055037,GO:0055038,GO:0055057,GO:0055059,GO:0060429,GO:0060627,GO:0061351,GO:0061564,GO:0061864,GO:0061951,GO:0065007,GO:0070201,GO:0070278,GO:0070382,GO:0070727,GO:0070887,GO:0070972,GO:0071071,GO:0071072,GO:0071236,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071532,GO:0071702,GO:0071704,GO:0071705,GO:0071782,GO:0071786,GO:0071840,GO:0071944,GO:0072089,GO:0072594,GO:0072599,GO:0072657,GO:0072659,GO:0080090,GO:0090150,GO:0097051,GO:0097159,GO:0097367,GO:0097458,GO:0097708,GO:0098588,GO:0098722,GO:0098791,GO:0098805,GO:0098827,GO:0098876,GO:0099503,GO:0110010,GO:0110011,GO:0120025,GO:0120036,GO:0120039,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902646,GO:1902647,GO:1903053,GO:1903361,GO:1903530,GO:1903725,GO:1903726,GO:1904951,GO:1990778	-	ko:K07903	ko04144,ko04152,map04144,map04152	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_7073389_1	5722.XP_001584373.1	2.224e-36	145.0	KOG0084@1|root,KOG0084@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	-	-	-	ko:K07874	ko05134,map05134	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_7073389_3	706587.Desti_2578	2.951e-16	88.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH1_k127_7073389_0	218851.Aquca_017_00087.1	8.109e-44	170.0	COG4354@1|root,KOG2119@2759|Eukaryota,37JKE@33090|Viridiplantae,3GG94@35493|Streptophyta	35493|Streptophyta	G	Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide	-	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0006082,GO:0006629,GO:0007275,GO:0007399,GO:0007417,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008422,GO:0009056,GO:0009987,GO:0015926,GO:0016020,GO:0016021,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0019752,GO:0021953,GO:0021954,GO:0022008,GO:0030154,GO:0030182,GO:0031224,GO:0032501,GO:0032502,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0048468,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0071704,GO:1901135,GO:1901136,GO:1901360,GO:1901575,GO:1901615,GO:1901657,GO:1901658	3.2.1.45	ko:K17108	ko00511,ko00600,ko01100,map00511,map00600,map01100	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH116	-	DUF608,Glyco_hydr_116N
EH1_k127_7097239_0	315730.BcerKBAB4_5553	6.555e-05	56.0	COG3420@1|root,COG3420@2|Bacteria,1UN63@1239|Firmicutes,4HAZN@91061|Bacilli,1ZE50@1386|Bacillus	91061|Bacilli	P	Periplasmic copper-binding protein (NosD)	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
EH1_k127_7135225_8	109760.SPPG_01459T0	7.768e-26	112.0	COG0638@1|root,KOG0178@2759|Eukaryota,38HA3@33154|Opisthokonta,3NVH4@4751|Fungi	4751|Fungi	O	proteasome subunit alpha	PRE9	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005839,GO:0006508,GO:0006511,GO:0006807,GO:0007088,GO:0007346,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009896,GO:0009987,GO:0010498,GO:0010499,GO:0010564,GO:0010638,GO:0010965,GO:0012505,GO:0016020,GO:0016043,GO:0019538,GO:0019773,GO:0019941,GO:0022607,GO:0030071,GO:0030163,GO:0031331,GO:0031597,GO:0032270,GO:0032436,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034515,GO:0034622,GO:0042175,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043248,GO:0043632,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045931,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051247,GO:0051603,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0062033,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080129,GO:0090068,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902494,GO:1903052,GO:1903364,GO:1905368,GO:1905369,GO:1905818,GO:1905820,GO:2001252	3.4.25.1	ko:K02728	ko03050,map03050	M00337,M00340	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
EH1_k127_7135225_5	368407.Memar_1677	4.049e-55	201.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
EH1_k127_7135225_4	694429.Pyrfu_1743	3.501e-57	209.0	COG1097@1|root,arCOG00678@2157|Archaea,2XQE2@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1,KH_6
EH1_k127_7135225_0	195522.BD01_2095	3.449e-79	274.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
EH1_k127_7135225_2	1151117.AJLF01000002_gene83	4.135e-72	254.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
EH1_k127_7135225_9	342949.PNA2_0520	5.105e-23	104.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
EH1_k127_7135225_11	374847.Kcr_1367	8.807e-08	61.0	COG2136@1|root,arCOG03247@2157|Archaea	2157|Archaea	AJ	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
EH1_k127_7135225_14	1071085.KK033114_gene346	7.211e-05	49.0	COG2892@1|root,arCOG04414@2157|Archaea,2XZUI@28890|Euryarchaeota,23XE5@183963|Halobacteria	183963|Halobacteria	S	KEOPS complex Pcc1-like subunit	pcc1	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
EH1_k127_7135225_10	593117.TGAM_1495	3.141e-10	66.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,244D1@183968|Thermococci	183968|Thermococci	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044464,GO:0071840	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
EH1_k127_7135225_6	415426.Hbut_0577	3.646e-43	171.0	COG0618@1|root,arCOG01565@2157|Archaea,2XQUB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
EH1_k127_7135225_1	374847.Kcr_1381	1.906e-72	254.0	COG1122@1|root,arCOG00188@2157|Archaea	2157|Archaea	P	PFAM ABC transporter related	phnG	-	2.7.8.37	ko:K03529,ko:K06166,ko:K16786,ko:K16787	ko00440,ko02010,map00440,map02010	M00582	R10185	RC00005,RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko03036	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,PhnG,SMC_N,SMC_hinge
EH1_k127_7135225_3	368408.Tpen_0713	1.411e-69	247.0	COG1122@1|root,arCOG00202@2157|Archaea	2157|Archaea	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
EH1_k127_7135225_7	195522.BD01_0706	1.773e-31	133.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota,2436Y@183968|Thermococci	183968|Thermococci	P	ABC-type cobalt transport system, permease	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
EH1_k127_7135225_13	936053.I1CI16	2.636e-06	53.0	KOG0274@1|root,KOG0274@2759|Eukaryota,38B8G@33154|Opisthokonta,3NYHA@4751|Fungi,1GVS1@112252|Fungi incertae sedis	4751|Fungi	S	A Receptor for Ubiquitination Targets	-	-	-	-	-	-	-	-	-	-	-	-	F-box,WD40
EH1_k127_7135225_12	593750.Metfor_2784	9.846e-07	57.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_11,HTH_24,HTH_27,HTH_5
EH1_k127_718996_4	756499.Desde_2173	2.107e-52	196.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPG1@1239|Firmicutes,24C2Y@186801|Clostridia,263T4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
EH1_k127_718996_1	1089553.Tph_c19580	1.591e-70	254.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,25ETM@186801|Clostridia,42I7T@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
EH1_k127_718996_2	1379698.RBG1_1C00001G1133	3.337e-67	243.0	COG1575@1|root,COG1575@2|Bacteria,2NPNN@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
EH1_k127_718996_3	1220534.B655_0860	9.999e-53	199.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23NK4@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
EH1_k127_718996_0	192952.MM_0718	2.386e-79	279.0	COG0644@1|root,arCOG00570@2157|Archaea,2XWXQ@28890|Euryarchaeota,2N9RD@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH1_k127_7195376_2	1042156.CXIVA_16150	2.331e-28	118.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	BBE,FAD_binding_4
EH1_k127_7195376_1	439235.Dalk_4040	5.425e-101	343.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42S94@68525|delta/epsilon subdivisions,2WNCW@28221|Deltaproteobacteria,2MNBQ@213118|Desulfobacterales	1224|Proteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
EH1_k127_7195376_0	439235.Dalk_4041	2.362e-115	391.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,42Q28@68525|delta/epsilon subdivisions,2WMZ9@28221|Deltaproteobacteria,2MPEE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	pcmI	-	1.17.99.1	ko:K05797	ko00623,ko01100,ko01120,map00623,map01100,map01120	-	R02675,R11194	RC00769	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_7195376_3	485913.Krac_4103	1.346e-10	70.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
EH1_k127_7244830_2	593750.Metfor_2578	6.141e-71	253.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
EH1_k127_7244830_5	304371.MCP_1198	2.224e-24	116.0	COG2202@1|root,arCOG02329@1|root,arCOG02329@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg
EH1_k127_7244830_1	1408473.JHXO01000010_gene3609	3.565e-106	353.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,2FX64@200643|Bacteroidia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH1_k127_7244830_4	246969.TAM4_812	8.317e-34	141.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2436S@183968|Thermococci	183968|Thermococci	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH1_k127_7244830_3	264732.Moth_0153	5.189e-34	136.0	COG1142@1|root,COG1142@2|Bacteria,1VH83@1239|Firmicutes,24TVN@186801|Clostridia,42JCX@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_4,Fer4_7
EH1_k127_7244830_0	574087.Acear_1487	7.423e-134	449.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WBG8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738,ko:K19515	ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200	M00309,M00541	R08571,R10961	RC00242,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_7252815_1	415426.Hbut_1243	2.572e-14	81.0	COG2129@1|root,arCOG01147@2157|Archaea,2XQK4@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
EH1_k127_7252815_0	227086.JGI_V11_51880	6.65e-30	130.0	KOG0078@1|root,KOG0078@2759|Eukaryota	2759|Eukaryota	S	GTPase activity	SEC4	GO:0000003,GO:0000131,GO:0000166,GO:0000910,GO:0001411,GO:0001882,GO:0001883,GO:0002790,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005768,GO:0005783,GO:0005886,GO:0005933,GO:0005934,GO:0005935,GO:0005937,GO:0006810,GO:0006887,GO:0006892,GO:0006893,GO:0006903,GO:0006904,GO:0006906,GO:0006914,GO:0006996,GO:0007049,GO:0007107,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009306,GO:0009653,GO:0009987,GO:0010927,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0017157,GO:0019001,GO:0019867,GO:0019953,GO:0022402,GO:0022406,GO:0022413,GO:0022414,GO:0022607,GO:0030133,GO:0030154,GO:0030427,GO:0030435,GO:0030437,GO:0031090,GO:0031321,GO:0031410,GO:0031521,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0031982,GO:0032502,GO:0032505,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0032940,GO:0032989,GO:0032991,GO:0033036,GO:0034293,GO:0034613,GO:0035639,GO:0035690,GO:0036094,GO:0042221,GO:0042493,GO:0042886,GO:0042995,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043332,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044248,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044703,GO:0045184,GO:0046903,GO:0048193,GO:0048278,GO:0048284,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051179,GO:0051234,GO:0051286,GO:0051301,GO:0051321,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051704,GO:0051716,GO:0060627,GO:0061024,GO:0061025,GO:0061919,GO:0065007,GO:0070727,GO:0070887,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0072659,GO:0090174,GO:0097159,GO:0097367,GO:0097708,GO:0098588,GO:0098805,GO:0098876,GO:0120025,GO:0120038,GO:0140029,GO:0140056,GO:1901265,GO:1901363,GO:1903046,GO:1903530,GO:1990778	-	ko:K07901	ko04144,ko04152,ko04530,ko04972,map04144,map04152,map04530,map04972	-	-	-	ko00000,ko00001,ko03036,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_7283832_5	926569.ANT_03760	1.303e-27	115.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
EH1_k127_7283832_0	391623.TERMP_00459	2.206e-113	379.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,242ZD@183968|Thermococci	183968|Thermococci	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
EH1_k127_7283832_3	573413.Spirs_1723	4.791e-40	161.0	COG1829@1|root,COG1829@2|Bacteria	2|Bacteria	S	kinase activity	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
EH1_k127_7283832_1	768672.Desfe_0418	9.458e-77	268.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
EH1_k127_7283832_2	401526.TcarDRAFT_1939	7.208e-53	198.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,4H595@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
EH1_k127_7283832_4	565033.GACE_1621	1.032e-28	120.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2467X@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_7335591_2	351160.LRC325	3.275e-23	102.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	ABC_cobalt,Oxidored_molyb
EH1_k127_7335591_3	1415780.JPOG01000001_gene3106	5.027e-21	106.0	COG0438@1|root,COG1409@1|root,COG0438@2|Bacteria,COG1409@2|Bacteria,1MUB7@1224|Proteobacteria,1RZ4V@1236|Gammaproteobacteria,1X6YI@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
EH1_k127_7335591_0	477974.Daud_1635	3.541e-148	485.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,26041@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
EH1_k127_7335591_1	572546.Arcpr_1231	8.648e-133	433.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,246UQ@183980|Archaeoglobi	183980|Archaeoglobi	F	IMP biosynthesis enzyme PurP domain protein	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
EH1_k127_7335591_4	693661.Arcve_0590	3.191e-14	74.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,245ZA@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
EH1_k127_736145_2	368407.Memar_1425	3.744e-06	58.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2N9P3@224756|Methanomicrobia	224756|Methanomicrobia	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
EH1_k127_736145_0	342451.SSP0028	3.659e-69	244.0	COG0863@1|root,COG0863@2|Bacteria,1VC9K@1239|Firmicutes,4HSVW@91061|Bacilli	91061|Bacilli	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
EH1_k127_736145_1	1151117.AJLF01000001_gene1013	1.089e-10	72.0	COG0454@1|root,arCOG00845@2157|Archaea,2Y67B@28890|Euryarchaeota,2430F@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH1_k127_7382357_2	869210.Marky_0886	2.467e-17	84.0	COG1409@1|root,COG1409@2|Bacteria,1WKV1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
EH1_k127_7382357_1	926560.KE387023_gene1657	4.554e-23	112.0	COG4805@1|root,COG4805@2|Bacteria,1WM4J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7382357_0	304371.MCP_1854	3.04e-47	183.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
EH1_k127_7382357_4	1500890.JQNL01000001_gene2344	1.671e-09	70.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7382357_3	568816.Acin_0566	6.958e-13	75.0	COG0589@1|root,COG0589@2|Bacteria,1U42A@1239|Firmicutes,4H5JT@909932|Negativicutes	909932|Negativicutes	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
EH1_k127_7434896_2	186497.PF0373	1.022e-22	108.0	COG0803@1|root,arCOG01005@2157|Archaea,2XVB3@28890|Euryarchaeota,242P1@183968|Thermococci	183968|Thermococci	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
EH1_k127_7434896_4	762966.HMPREF9439_00285	7.169e-07	56.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,2VR6M@28216|Betaproteobacteria,4PR7S@995019|Sutterellaceae	28216|Betaproteobacteria	K	Transcriptional regulator	nikR	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
EH1_k127_7434896_1	693661.Arcve_1255	4.05e-48	182.0	COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1121 ABC-type Mn Zn transport systems ATPase component	znuC1	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
EH1_k127_7434896_0	693661.Arcve_1256	5.491e-51	194.0	COG1108@1|root,arCOG01006@2157|Archaea,2XTNB@28890|Euryarchaeota	28890|Euryarchaeota	P	COG1108 ABC-type Mn2 Zn2 transport systems permease components	znuB1	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	iAF692.Mbar_A0996	ABC-3
EH1_k127_7434896_3	224325.AF_0490	7.397e-15	77.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,246RW@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
EH1_k127_7438470_1	593750.Metfor_2049	1.496e-91	316.0	COG4294@1|root,arCOG01898@2157|Archaea,2XVT2@28890|Euryarchaeota	28890|Euryarchaeota	L	UV-endonuclease UvdE	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
EH1_k127_7438470_0	1125863.JAFN01000001_gene929	1.134e-202	651.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
EH1_k127_7466927_1	391009.Tmel_0561	2.805e-67	234.0	COG0444@1|root,COG0444@2|Bacteria,2GCDR@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH1_k127_7466927_0	439481.Aboo_0845	1.194e-98	336.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
EH1_k127_7466927_2	756883.Halar_2809	2.188e-64	235.0	COG3608@1|root,arCOG02890@2157|Archaea	2157|Archaea	O	Succinylglutamate desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
EH1_k127_7466927_3	304371.MCP_1481	3.401e-41	164.0	28M2T@1|root,2N55N@2157|Archaea,2Y31V@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7466927_4	304371.MCP_1482	6.909e-32	126.0	COG0574@1|root,arCOG01114@2157|Archaea,2XVSY@28890|Euryarchaeota	28890|Euryarchaeota	G	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
EH1_k127_7487437_2	56780.SYN_00663	1.138e-39	154.0	COG1751@1|root,COG1751@2|Bacteria,1RBXI@1224|Proteobacteria,42R3D@68525|delta/epsilon subdivisions,2WMRV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
EH1_k127_7487437_1	382464.ABSI01000010_gene3750	2.809e-94	319.0	COG0484@1|root,COG0484@2|Bacteria,46TKC@74201|Verrucomicrobia,2ITUR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
EH1_k127_7487437_0	1209989.TepiRe1_1197	4.376e-236	745.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,42F10@68295|Thermoanaerobacterales	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
EH1_k127_7487437_3	1009370.ALO_13654	2.554e-09	60.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4H4K0@909932|Negativicutes	909932|Negativicutes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
EH1_k127_7574313_1	391623.TERMP_00518	9.829e-79	277.0	COG0624@1|root,arCOG01107@2157|Archaea,2Y315@28890|Euryarchaeota,242ZX@183968|Thermococci	183968|Thermococci	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Peptidase_M20
EH1_k127_7574313_0	1343739.PAP_00935	2.371e-263	846.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,242NA@183968|Thermococci	183968|Thermococci	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
EH1_k127_7576828_1	8081.XP_008410947.1	4.737e-05	53.0	COG5491@1|root,KOG3232@2759|Eukaryota,38DT1@33154|Opisthokonta,3BAHW@33208|Metazoa,3CTBG@33213|Bilateria,480BJ@7711|Chordata,490A8@7742|Vertebrata,49ZH5@7898|Actinopterygii	33208|Metazoa	U	Charged multivesicular body protein	CHMP1A	GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000793,GO:0000794,GO:0000819,GO:0000920,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005768,GO:0005769,GO:0005815,GO:0005856,GO:0006323,GO:0006355,GO:0006508,GO:0006807,GO:0006810,GO:0006996,GO:0006997,GO:0007032,GO:0007049,GO:0007059,GO:0007076,GO:0007080,GO:0007088,GO:0007275,GO:0007346,GO:0007399,GO:0007417,GO:0007420,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010558,GO:0010564,GO:0010605,GO:0010629,GO:0010824,GO:0012505,GO:0015630,GO:0016020,GO:0016032,GO:0016043,GO:0016050,GO:0016192,GO:0016363,GO:0016458,GO:0016787,GO:0019058,GO:0019068,GO:0019219,GO:0019222,GO:0019538,GO:0019904,GO:0021549,GO:0022037,GO:0022402,GO:0022411,GO:0022607,GO:0030261,GO:0030902,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032501,GO:0032502,GO:0032886,GO:0032984,GO:0033043,GO:0034399,GO:0036257,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044087,GO:0044238,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0045786,GO:0045892,GO:0045934,GO:0046605,GO:0046755,GO:0046872,GO:0046914,GO:0046983,GO:0048285,GO:0048513,GO:0048519,GO:0048523,GO:0048731,GO:0048856,GO:0050000,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051276,GO:0051301,GO:0051303,GO:0051310,GO:0051493,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0051704,GO:0051726,GO:0051783,GO:0060236,GO:0060255,GO:0060322,GO:0065007,GO:0070011,GO:0070013,GO:0070507,GO:0070925,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090169,GO:0090224,GO:0097708,GO:0098588,GO:0098805,GO:0098813,GO:0140014,GO:0140096,GO:1901564,GO:1901673,GO:1902115,GO:1902679,GO:1903047,GO:1903506,GO:1903507,GO:1904896,GO:1904903,GO:2000112,GO:2000113,GO:2001141	-	ko:K12197	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	Snf7
EH1_k127_7576828_0	9823.ENSSSCP00000005264	1.642e-75	268.0	KOG0739@1|root,KOG0739@2759|Eukaryota,38D1Q@33154|Opisthokonta,3BCY8@33208|Metazoa,3DEB2@33213|Bilateria,48IEF@7711|Chordata,49EBQ@7742|Vertebrata,3JIWP@40674|Mammalia,4JCE8@91561|Cetartiodactyla	33208|Metazoa	O	IstB-like ATP binding protein	VPS4B	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464	-	ko:K12196	ko04144,ko04217,map04144,map04217	M00412	-	-	ko00000,ko00001,ko00002,ko04131	-	-	-	AAA,MIT,Vps4_C
EH1_k127_7640190_3	243232.MJ_0719	3.857e-54	193.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,23Q3J@183939|Methanococci	183939|Methanococci	E	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
EH1_k127_7640190_1	1343739.PAP_08445	1.199e-104	346.0	COG2820@1|root,arCOG01324@2157|Archaea,2XSWN@28890|Euryarchaeota,243RY@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
EH1_k127_7640190_2	1051632.TPY_1071	1.989e-102	341.0	COG1830@1|root,COG1830@2|Bacteria,1TR4S@1239|Firmicutes,24CYU@186801|Clostridia	186801|Clostridia	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
EH1_k127_7640190_0	272557.APE_1109.1	4.878e-149	482.0	COG1980@1|root,arCOG04180@2157|Archaea,2XPV4@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	GO:0000287,GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016830,GO:0016832,GO:0019203,GO:0019318,GO:0019319,GO:0019362,GO:0019637,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0046483,GO:0046496,GO:0046872,GO:0050308,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901360,GO:1901564,GO:1901576	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
EH1_k127_7640190_4	720554.Clocl_3125	1.998e-10	61.0	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,3WNNC@541000|Ruminococcaceae	186801|Clostridia	O	PPIC-type PPIASE domain	prsA2	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
EH1_k127_7656123_0	272844.PAB2313	6.04e-175	580.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,24373@183968|Thermococci	183968|Thermococci	L	helicase superfamily c-terminal domain	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
EH1_k127_7656123_6	644281.MFS40622_0146	3.988e-07	56.0	COG2034@1|root,arCOG02717@2157|Archaea,2Y6J3@28890|Euryarchaeota,23RTU@183939|Methanococci	183939|Methanococci	S	Protein of unknown function DUF131	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
EH1_k127_7656123_4	985053.VMUT_1828	1.388e-30	127.0	arCOG05489@1|root,arCOG05489@2157|Archaea,2XQT5@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7656123_3	178306.PAE3418	2.912e-35	147.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
EH1_k127_7656123_2	529709.PYCH_12090	7.038e-62	225.0	COG1063@1|root,arCOG01459@2157|Archaea,2Y683@28890|Euryarchaeota,2450G@183968|Thermococci	183968|Thermococci	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
EH1_k127_7656123_1	246969.TAM4_453	2.946e-86	300.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,243BB@183968|Thermococci	183968|Thermococci	S	PFAM PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
EH1_k127_7656123_5	453591.Igni_0828	1.398e-22	100.0	COG3357@1|root,arCOG04479@2157|Archaea,2XR5D@28889|Crenarchaeota	28889|Crenarchaeota	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	-
EH1_k127_7662678_1	1117379.BABA_03774	2.615e-33	135.0	COG2021@1|root,COG2021@2|Bacteria,1UN0R@1239|Firmicutes,4IUMT@91061|Bacilli,1ZSGR@1386|Bacillus	91061|Bacilli	E	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
EH1_k127_7662678_0	292564.Cyagr_3056	5.722e-88	303.0	2EVJP@1|root,33NZT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7679662_0	1123508.JH636439_gene1367	8.044e-60	230.0	COG0433@1|root,COG2887@1|root,COG0433@2|Bacteria,COG2887@2|Bacteria,2IY71@203682|Planctomycetes	203682|Planctomycetes	L	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87,PDDEXK_1
EH1_k127_7679662_1	639282.DEFDS_0706	2.31e-43	171.0	COG0672@1|root,COG0672@2|Bacteria,2GGKP@200930|Deferribacteres	200930|Deferribacteres	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
EH1_k127_7679662_4	203267.TWT_742	3.278e-20	100.0	COG0647@1|root,COG0647@2|Bacteria,2GJG6@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the HAD-like hydrolase superfamily	nagD	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
EH1_k127_7679662_3	604354.TSIB_1238	1.431e-23	106.0	COG1917@1|root,arCOG02994@2157|Archaea,2XZAN@28890|Euryarchaeota,2446X@183968|Thermococci	183968|Thermococci	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
EH1_k127_7679662_2	269797.Mbar_A1752	1.481e-42	166.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
EH1_k127_7688208_5	523845.AQXV01000055_gene71	1.138e-23	117.0	COG1002@1|root,arCOG02634@2157|Archaea,arCOG02635@2157|Archaea,2Y89W@28890|Euryarchaeota,23R3Q@183939|Methanococci	183939|Methanococci	L	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase,TaqI_C
EH1_k127_7688208_0	251221.35211855	1.256e-97	338.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
EH1_k127_7688208_1	368408.Tpen_1035	3.106e-74	259.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
EH1_k127_7688208_3	1210908.HSB1_26060	1.367e-32	137.0	COG1234@1|root,arCOG00500@2157|Archaea,2XTUD@28890|Euryarchaeota,23STE@183963|Halobacteria	183963|Halobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
EH1_k127_7688208_9	1206731.BAGB01000049_gene4935	0.0002224	51.0	COG2909@1|root,COG3267@1|root,COG2909@2|Bacteria,COG3267@2|Bacteria,2GJXF@201174|Actinobacteria,4G9G7@85025|Nocardiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03556,ko:K06886	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
EH1_k127_7688208_4	720554.Clocl_3514	1.093e-25	117.0	28IEB@1|root,2Z8GD@2|Bacteria,1VCER@1239|Firmicutes,251XP@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7688208_2	457405.FSDG_00309	1.138e-42	162.0	COG2030@1|root,COG2030@2|Bacteria,37A21@32066|Fusobacteria	32066|Fusobacteria	I	N-terminal half of MaoC dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
EH1_k127_7688208_6	688269.Theth_1245	1.422e-11	70.0	COG0332@1|root,COG0332@2|Bacteria,2GC8A@200918|Thermotogae	200918|Thermotogae	I	PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
EH1_k127_7688208_8	411467.BACCAP_00869	0.0002049	52.0	COG0693@1|root,COG0693@2|Bacteria,1V3WB@1239|Firmicutes,24HGU@186801|Clostridia,2691M@186813|unclassified Clostridiales	186801|Clostridia	S	DJ-1/PfpI family	yajL	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
EH1_k127_7694740_1	572478.Vdis_0392	1.2e-70	246.0	COG0674@1|root,arCOG01606@2157|Archaea,2XQ12@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
EH1_k127_7694740_0	1459636.NTE_01234	1.726e-139	450.0	COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
EH1_k127_7725829_0	797114.C475_19298	5.667e-05	50.0	COG0640@1|root,arCOG00394@2157|Archaea,2Y4HA@28890|Euryarchaeota,2403Q@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7725829_1	304371.MCP_0053	0.0001488	53.0	COG2202@1|root,arCOG06515@2157|Archaea	304371.MCP_0053|-	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7757918_1	1123009.AUID01000001_gene1051	7.525e-62	217.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,267M9@186813|unclassified Clostridiales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
EH1_k127_7757918_0	1304880.JAGB01000002_gene1765	3.733e-311	974.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
EH1_k127_7759585_9	309799.DICTH_1588	1.686e-06	51.0	COG4952@1|root,COG4952@2|Bacteria	2|Bacteria	M	isomerase activity	xylA_2	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
EH1_k127_7759585_1	1499967.BAYZ01000057_gene4667	1.857e-188	603.0	COG1070@1|root,COG1070@2|Bacteria,2NQ9W@2323|unclassified Bacteria	2|Bacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	1.1.1.57,2.7.1.17	ko:K00040,ko:K00854,ko:K19168	ko00040,ko01100,map00040,map01100	M00014,M00061	R01639,R02454	RC00002,RC00085,RC00538	ko00000,ko00001,ko00002,ko01000,ko02048	-	-	-	FGGY_C,FGGY_N
EH1_k127_7759585_0	1195236.CTER_3560	4.006e-213	682.0	COG1472@1|root,COG1472@2|Bacteria,1VSFU@1239|Firmicutes,25BFI@186801|Clostridia	186801|Clostridia	G	PFAM Glycosyl hydrolase family 3 C terminal domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
EH1_k127_7759585_6	1380391.JIAS01000011_gene5393	7.739e-58	204.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2U2CJ@28211|Alphaproteobacteria,2JZPG@204441|Rhodospirillales	204441|Rhodospirillales	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
EH1_k127_7759585_4	1150474.JQJI01000001_gene1807	1.863e-79	275.0	COG1079@1|root,COG1079@2|Bacteria,2GCR8@200918|Thermotogae	200918|Thermotogae	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
EH1_k127_7759585_5	511051.CSE_09000	2.052e-67	244.0	COG4603@1|root,COG4603@2|Bacteria	2|Bacteria	L	Belongs to the binding-protein-dependent transport system permease family	tsgB13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
EH1_k127_7759585_3	273068.TTE0458	2.294e-113	384.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,42F9A@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
EH1_k127_7759585_2	670487.Ocepr_0131	7.535e-127	422.0	COG1744@1|root,COG1744@2|Bacteria,1WIU4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
EH1_k127_7759585_7	926561.KB900622_gene463	1.574e-28	119.0	29X3G@1|root,30IS5@2|Bacteria,1W5BE@1239|Firmicutes,24MZE@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
EH1_k127_7759585_8	1379698.RBG1_1C00001G0234	3.217e-11	71.0	COG1404@1|root,COG5276@1|root,COG1404@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria	2|Bacteria	P	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,LVIVD
EH1_k127_777588_2	374847.Kcr_0332	1.407e-06	58.0	arCOG03462@1|root,arCOG03462@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
EH1_k127_777588_1	1094980.Mpsy_1686	4.227e-44	168.0	COG5012@1|root,arCOG02028@2157|Archaea,2XX6R@28890|Euryarchaeota,2NA0S@224756|Methanomicrobia	224756|Methanomicrobia	S	Acts probably as a methyl group carrier between MttB and either MtbA or MtaA	-	-	-	ko:K14084	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124	RC00035,RC00732,RC02984	ko00000,ko00001,ko00002	-	-	iAF692.Mbar_A1503	B12-binding,B12-binding_2
EH1_k127_777588_0	913865.DOT_4724	3.095e-66	244.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24CK1@186801|Clostridia,25ZYG@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
EH1_k127_7791487_0	1110697.NCAST_32_01250	1.923e-17	90.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria,4FUGJ@85025|Nocardiaceae	201174|Actinobacteria	P	Bacterial Na+/H+ antiporter B (NhaB)	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
EH1_k127_7791513_4	926550.CLDAP_10970	8.702e-11	73.0	COG0078@1|root,COG0078@2|Bacteria,2G7QE@200795|Chloroflexi	200795|Chloroflexi	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	-	2.1.3.9	ko:K09065	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
EH1_k127_7791513_0	1365176.N186_05835	3.291e-118	392.0	COG1313@1|root,arCOG00934@2157|Archaea,2XPK3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
EH1_k127_7791513_2	1944.JOAZ01000003_gene5176	3.305e-17	87.0	COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria	201174|Actinobacteria	O	Hydrogenase expression formation protein	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
EH1_k127_7791513_3	1449063.JMLS01000013_gene6156	1.635e-11	74.0	COG0241@1|root,COG1208@1|root,COG0241@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,4IS8X@91061|Bacilli,277CZ@186822|Paenibacillaceae	91061|Bacilli	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like,NTP_transferase
EH1_k127_7791513_1	572478.Vdis_0006	3.707e-29	123.0	COG0463@1|root,arCOG00895@2157|Archaea,2XSPD@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
EH1_k127_7808600_2	515635.Dtur_1640	2.374e-21	104.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH1_k127_7808600_0	933262.AXAM01000035_gene2154	3.157e-59	217.0	2E0M7@1|root,32W6F@2|Bacteria,1NB9Z@1224|Proteobacteria,42W6T@68525|delta/epsilon subdivisions,2WSFF@28221|Deltaproteobacteria,2MNT8@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7808600_1	304371.MCP_1435	5.337e-26	117.0	COG2202@1|root,arCOG03931@1|root,arCOG06712@1|root,arCOG03931@2157|Archaea,arCOG06538@2157|Archaea,arCOG06712@2157|Archaea,2Y3TD@28890|Euryarchaeota,2NAV1@224756|Methanomicrobia	224756|Methanomicrobia	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
EH1_k127_7834286_2	1094980.Mpsy_2013	4.059e-15	83.0	COG1233@1|root,arCOG01524@2157|Archaea,2XSYN@28890|Euryarchaeota,2NA9X@224756|Methanomicrobia	224756|Methanomicrobia	Q	GDP dissociation inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
EH1_k127_7834286_0	69014.TK1978	2.217e-55	199.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
EH1_k127_7834286_1	1229909.NSED_03065	5.258e-32	132.0	COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
EH1_k127_787733_0	243232.MJ_1377	2.921e-133	445.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,23Q9N@183939|Methanococci	183939|Methanococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
EH1_k127_787733_1	43151.ADAC005928-PA	0.0006962	51.0	KOG3341@1|root,KOG3341@2759|Eukaryota,38FCZ@33154|Opisthokonta,3B9KQ@33208|Metazoa,3CUGF@33213|Bilateria,41UN2@6656|Arthropoda,3SFS4@50557|Insecta,44XJI@7147|Diptera,45EXT@7148|Nematocera	33208|Metazoa	U	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs	SNF8	GO:0000003,GO:0000578,GO:0000814,GO:0003002,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006403,GO:0006508,GO:0006511,GO:0006807,GO:0006810,GO:0006886,GO:0006914,GO:0006996,GO:0007032,GO:0007034,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007308,GO:0007309,GO:0007314,GO:0007350,GO:0007351,GO:0007389,GO:0008022,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0008298,GO:0008358,GO:0008593,GO:0008595,GO:0009056,GO:0009057,GO:0009790,GO:0009798,GO:0009880,GO:0009889,GO:0009893,GO:0009894,GO:0009896,GO:0009948,GO:0009952,GO:0009966,GO:0009968,GO:0009987,GO:0009994,GO:0010008,GO:0010256,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010796,GO:0010797,GO:0010941,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016192,GO:0016197,GO:0016236,GO:0016247,GO:0016482,GO:0017157,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0019953,GO:0021700,GO:0022412,GO:0022414,GO:0022607,GO:0023051,GO:0023057,GO:0030154,GO:0030163,GO:0031090,GO:0031323,GO:0031326,GO:0031410,GO:0031902,GO:0031974,GO:0031981,GO:0031982,GO:0032456,GO:0032501,GO:0032502,GO:0032504,GO:0032509,GO:0032511,GO:0032535,GO:0032879,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0035282,GO:0036257,GO:0036258,GO:0036452,GO:0042058,GO:0042059,GO:0042176,GO:0042802,GO:0042803,GO:0042886,GO:0042981,GO:0043067,GO:0043162,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043328,GO:0043632,GO:0043900,GO:0043903,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045022,GO:0045184,GO:0045324,GO:0045450,GO:0045732,GO:0045921,GO:0046907,GO:0046983,GO:0047485,GO:0048468,GO:0048469,GO:0048471,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048599,GO:0048609,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0051036,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051252,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0055037,GO:0060255,GO:0060627,GO:0060810,GO:0060811,GO:0061635,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0071985,GO:0072594,GO:0072665,GO:0072666,GO:0080090,GO:0090066,GO:0097708,GO:0098588,GO:0098772,GO:0098796,GO:0098805,GO:0098927,GO:1901184,GO:1901185,GO:1901564,GO:1901565,GO:1901575,GO:1903506,GO:1903530,GO:1903532,GO:1903541,GO:1903543,GO:1903772,GO:1903900,GO:2000112,GO:2001141	-	ko:K12188	ko04144,map04144	M00410	-	-	ko00000,ko00001,ko00002,ko04131,ko04147	-	-	-	EAP30
EH1_k127_7894513_1	484770.UFO1_4023	1.304e-53	207.0	COG3075@1|root,COG3075@2|Bacteria,1UXV7@1239|Firmicutes,4H3GE@909932|Negativicutes	909932|Negativicutes	E	PFAM fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
EH1_k127_7894513_0	404589.Anae109_1336	5.467e-95	332.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42M8D@68525|delta/epsilon subdivisions,2WJ6E@28221|Deltaproteobacteria,2YWFY@29|Myxococcales	28221|Deltaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C,Fer2_BFD
EH1_k127_7902294_1	565033.GACE_1903	1.897e-74	268.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
EH1_k127_7902294_4	1265505.ATUG01000002_gene1142	7.005e-40	167.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,43B2Q@68525|delta/epsilon subdivisions,2WK38@28221|Deltaproteobacteria,2MJTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_7902294_2	1329516.JPST01000003_gene1189	1.416e-70	248.0	COG3970@1|root,COG3970@2|Bacteria,1U819@1239|Firmicutes,4HDEZ@91061|Bacilli	91061|Bacilli	S	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
EH1_k127_7902294_6	374847.Kcr_0903	2.22e-10	69.0	COG2229@1|root,arCOG00362@2157|Archaea	2157|Archaea	K	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	GTP_EFTU,P-II
EH1_k127_7902294_9	1117108.PAALTS15_07319	1.879e-05	54.0	COG4720@1|root,COG4720@2|Bacteria,1V1GT@1239|Firmicutes,4HGAE@91061|Bacilli,26VVU@186822|Paenibacillaceae	91061|Bacilli	S	ECF-type riboflavin transporter, S component	-	-	-	ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.29	-	-	ECF-ribofla_trS
EH1_k127_7902294_8	1437824.BN940_14136	7.339e-06	59.0	28IIF@1|root,2Z8JJ@2|Bacteria,1NUA0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	4.2.1.127,5.4.4.4	ko:K20614	-	-	-	-	ko00000,ko01000	-	-	-	-
EH1_k127_7902294_3	411468.CLOSCI_00801	3.962e-56	203.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,220S6@1506553|Lachnoclostridium	186801|Clostridia	G	COG COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
EH1_k127_7902294_0	324057.Pjdr2_1891	6.554e-201	637.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HVE0@91061|Bacilli,271P8@186822|Paenibacillaceae	91061|Bacilli	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH1_k127_7902294_5	416591.Tlet_1438	1.943e-11	77.0	COG0747@1|root,COG0747@2|Bacteria,2GCPN@200918|Thermotogae	200918|Thermotogae	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_7902294_7	1123229.AUBC01000047_gene3804	6.646e-09	69.0	COG0747@1|root,COG0747@2|Bacteria,1R59W@1224|Proteobacteria,2U7T7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_7914880_1	868595.Desca_0835	1.517e-56	218.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,2601P@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
EH1_k127_7914880_2	1122915.AUGY01000001_gene7114	2.295e-16	87.0	COG2318@1|root,COG2318@2|Bacteria,1VI69@1239|Firmicutes,4HPG9@91061|Bacilli,26TJI@186822|Paenibacillaceae	91061|Bacilli	S	DinB superfamily	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
EH1_k127_7914880_0	309807.SRU_0049	4.682e-91	311.0	COG2309@1|root,COG2309@2|Bacteria,4NRU3@976|Bacteroidetes	976|Bacteroidetes	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
EH1_k127_7924882_0	1365176.N186_00370	1.287e-39	154.0	COG0451@1|root,arCOG01369@2157|Archaea,2XRSX@28889|Crenarchaeota	28889|Crenarchaeota	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
EH1_k127_7924882_3	65672.G4T4W2	0.0007709	51.0	KOG1125@1|root,KOG1125@2759|Eukaryota,38C1T@33154|Opisthokonta,3NVEX@4751|Fungi,3UY4W@5204|Basidiomycota,227UU@155619|Agaricomycetes,3H1GC@355688|Agaricomycetes incertae sedis	4751|Fungi	S	Tetratricopeptide repeat	-	-	-	ko:K13342	ko04146,map04146	-	-	-	ko00000,ko00001,ko04131	3.A.20.1	-	-	TPR_1,TPR_16,TPR_19,TPR_8
EH1_k127_7924882_1	96561.Dole_1578	1.376e-08	67.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1R7IR@1224|Proteobacteria,42MT7@68525|delta/epsilon subdivisions,2WITW@28221|Deltaproteobacteria,2MJDP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,TPR_1,TPR_14,TPR_2,TPR_8
EH1_k127_7924882_2	1122971.BAME01000092_gene5630	1.97e-05	50.0	COG0842@1|root,COG0842@2|Bacteria,4NDU0@976|Bacteroidetes,2FMJ3@200643|Bacteroidia,22WTM@171551|Porphyromonadaceae	976|Bacteroidetes	V	Transport permease protein	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
EH1_k127_7928536_0	224325.AF_1815	9.503e-168	539.0	COG4992@1|root,arCOG00914@2157|Archaea,2XTKV@28890|Euryarchaeota,24610@183980|Archaeoglobi	28890|Euryarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH1_k127_7928536_2	1206737.BAGF01000062_gene4155	1.027e-52	192.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria,4G0JA@85025|Nocardiaceae	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
EH1_k127_7929803_1	1121946.AUAX01000001_gene2234	2.749e-36	156.0	COG5316@1|root,COG5316@2|Bacteria,2GN81@201174|Actinobacteria,4D9MM@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
EH1_k127_7929803_0	1167006.UWK_03340	3.404e-221	698.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MI0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
EH1_k127_793266_2	400682.PAC_15720459	1.459e-12	74.0	KOG0078@1|root,KOG0078@2759|Eukaryota,39RSX@33154|Opisthokonta,3BJT1@33208|Metazoa	33208|Metazoa	U	RAB13, member RAS oncogene family	RAB13	GO:0000003,GO:0000166,GO:0001525,GO:0001568,GO:0001667,GO:0001882,GO:0001883,GO:0001944,GO:0002064,GO:0003006,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0006464,GO:0006807,GO:0006810,GO:0006886,GO:0006928,GO:0006935,GO:0006996,GO:0007010,GO:0007043,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007548,GO:0008104,GO:0008150,GO:0008152,GO:0008406,GO:0008584,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0010033,GO:0010243,GO:0010631,GO:0010737,GO:0010827,GO:0010828,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016197,GO:0016328,GO:0016462,GO:0016477,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019897,GO:0019898,GO:0019899,GO:0019900,GO:0019901,GO:0022008,GO:0022414,GO:0022607,GO:0023052,GO:0030027,GO:0030029,GO:0030030,GO:0030036,GO:0030054,GO:0030139,GO:0030141,GO:0030154,GO:0030182,GO:0030659,GO:0030855,GO:0030865,GO:0030866,GO:0031090,GO:0031175,GO:0031252,GO:0031410,GO:0031982,GO:0031984,GO:0032456,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032593,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0033036,GO:0033500,GO:0034236,GO:0034329,GO:0034330,GO:0034613,GO:0034762,GO:0034764,GO:0035239,GO:0035295,GO:0035556,GO:0035639,GO:0035767,GO:0036094,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0042592,GO:0042593,GO:0042886,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043296,GO:0043297,GO:0043412,GO:0043434,GO:0043542,GO:0043687,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044795,GO:0045137,GO:0045184,GO:0045216,GO:0046324,GO:0046326,GO:0046546,GO:0046661,GO:0046907,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048608,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051018,GO:0051049,GO:0051050,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051674,GO:0051716,GO:0055037,GO:0060008,GO:0060009,GO:0060326,GO:0060429,GO:0061458,GO:0065007,GO:0065008,GO:0070160,GO:0070727,GO:0070830,GO:0070887,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0072358,GO:0072359,GO:0072657,GO:0072659,GO:0090130,GO:0090132,GO:0097159,GO:0097367,GO:0097368,GO:0097458,GO:0097708,GO:0098791,GO:0099503,GO:0120025,GO:0120036,GO:1901265,GO:1901363,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902463,GO:1990778	-	ko:K06109	ko04530,map04530	-	-	-	ko00000,ko00001,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_793266_4	404589.Anae109_3584	0.0005764	50.0	COG0546@1|root,COG0546@2|Bacteria,1P19B@1224|Proteobacteria,431NT@68525|delta/epsilon subdivisions,2WWU8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_793266_1	351160.LRC596	2.1e-24	120.0	arCOG02352@1|root,arCOG06516@1|root,arCOG02352@2157|Archaea,arCOG06516@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg
EH1_k127_793266_0	246197.MXAN_3757	2.571e-33	139.0	COG1024@1|root,COG1024@2|Bacteria,1MW41@1224|Proteobacteria,42N51@68525|delta/epsilon subdivisions,2WKBV@28221|Deltaproteobacteria,2YUYZ@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
EH1_k127_7934683_2	398720.MED217_12294	4.799e-13	80.0	COG1305@1|root,COG1305@2|Bacteria,4NFI4@976|Bacteroidetes,1HZ26@117743|Flavobacteriia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
EH1_k127_7934683_0	985053.VMUT_0238	2.757e-109	363.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
EH1_k127_7934683_1	797299.HALLA_09865	1.094e-15	88.0	arCOG03129@1|root,arCOG03129@2157|Archaea,2XTF9@28890|Euryarchaeota,23T0X@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF2797)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2797
EH1_k127_7951002_2	32057.KB217478_gene2348	7.954e-11	73.0	COG0679@1|root,COG0679@2|Bacteria,1G30E@1117|Cyanobacteria,1HTYQ@1161|Nostocales	1117|Cyanobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
EH1_k127_7951002_0	1163730.FFONT_0226	5.437e-144	477.0	COG2414@1|root,arCOG00706@2157|Archaea,2XQ6E@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
EH1_k127_7951002_1	1163730.FFONT_0548	1.11e-23	103.0	COG0235@1|root,arCOG04226@2157|Archaea,2XQGF@28889|Crenarchaeota	28889|Crenarchaeota	G	Class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
EH1_k127_7953388_7	69014.TK2264	1.897e-33	152.0	COG1800@1|root,arCOG07561@1|root,arCOG02164@2157|Archaea,arCOG07561@2157|Archaea,2XV3J@28890|Euryarchaeota,2435K@183968|Thermococci	183968|Thermococci	K	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
EH1_k127_7953388_5	234267.Acid_5754	6.14e-43	160.0	COG3324@1|root,COG3324@2|Bacteria,3Y8A9@57723|Acidobacteria	57723|Acidobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
EH1_k127_7953388_16	706587.Desti_2132	0.0009704	51.0	COG2271@1|root,COG2271@2|Bacteria,1QUCH@1224|Proteobacteria,42Y5F@68525|delta/epsilon subdivisions,2WUBT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Sugar (and other) transporter	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,Sugar_tr
EH1_k127_7953388_3	304371.MCP_2060	9.338e-49	189.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7953388_6	351160.RCIX179	7.956e-38	159.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_7953388_9	593750.Metfor_2783	2.322e-15	80.0	arCOG11509@1|root,arCOG11509@2157|Archaea,2Y3KG@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7953388_12	1229909.NSED_05310	1.22e-06	57.0	arCOG10526@1|root,arCOG10526@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7953388_1	580331.Thit_0631	4.476e-140	465.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,42ERQ@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
EH1_k127_7953388_8	1122604.JONR01000022_gene671	1.235e-28	124.0	2CD6U@1|root,32RX5@2|Bacteria,1N8DY@1224|Proteobacteria,1SF31@1236|Gammaproteobacteria,1X8KS@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7953388_4	1192034.CAP_0500	2.188e-47	180.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2Z33Y@29|Myxococcales	28221|Deltaproteobacteria	M	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
EH1_k127_7953388_14	1192034.CAP_0500	5.633e-06	53.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2Z33Y@29|Myxococcales	28221|Deltaproteobacteria	M	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
EH1_k127_7953388_2	536227.CcarbDRAFT_0754	1.343e-80	275.0	COG2872@1|root,COG2872@2|Bacteria,1UHS6@1239|Firmicutes,24AK0@186801|Clostridia,36GRN@31979|Clostridiaceae	186801|Clostridia	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
EH1_k127_7953388_15	400682.PAC_15703539	6.265e-06	54.0	KOG1128@1|root,KOG1128@2759|Eukaryota,38BIC@33154|Opisthokonta,3BGWF@33208|Metazoa	33208|Metazoa	IQ	tetratricopeptide repeat	TTC27	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
EH1_k127_7953388_13	1541960.KQ78_01444	1.496e-06	60.0	2E6H4@1|root,3314B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7953388_10	584708.Apau_1004	2.06e-09	66.0	2ENZG@1|root,33GKC@2|Bacteria,3TBSZ@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7953388_0	269797.Mbar_A0543	1.746e-227	725.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,2N99D@224756|Methanomicrobia	224756|Methanomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
EH1_k127_7973642_3	521011.Mpal_0423	1.279e-41	174.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
EH1_k127_7973642_5	883067.HMPREF9237_00042	3.792e-10	75.0	COG2885@1|root,COG3064@1|root,COG2885@2|Bacteria,COG3064@2|Bacteria,2IC22@201174|Actinobacteria,4D3XJ@85005|Actinomycetales	201174|Actinobacteria	M	tail sheath protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	He_PIG,Rib,TSP_3
EH1_k127_7973642_2	1094980.Mpsy_3151	2.029e-47	198.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_7973642_4	304371.MCP_2203	2.267e-23	111.0	COG1266@1|root,arCOG02766@2157|Archaea	2157|Archaea	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH1_k127_7973642_1	1121423.JONT01000010_gene1827	3.59e-63	235.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,260J4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_7973642_0	1236689.MMALV_16610	4.329e-70	251.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota	28890|Euryarchaeota	C	reductase	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
EH1_k127_7982343_1	1043493.BBLU01000003_gene2464	2.44e-35	141.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
EH1_k127_7982343_3	634452.APA01_04120	3e-07	62.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,2JPJR@204441|Rhodospirillales	204441|Rhodospirillales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
EH1_k127_7982343_0	195103.CPF_0375	1.177e-57	214.0	COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,36UH1@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
EH1_k127_7982343_2	1227453.C444_19642	2.062e-19	89.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,23SA4@183963|Halobacteria	183963|Halobacteria	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
EH1_k127_7990999_4	1463879.JOHP01000044_gene188	1.486e-11	68.0	COG1619@1|root,COG1619@2|Bacteria,2GNW5@201174|Actinobacteria	201174|Actinobacteria	V	proteins homologs of microcin C7 resistance protein MccF	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
EH1_k127_7990999_2	1120971.AUCA01000027_gene703	1.139e-43	175.0	COG0644@1|root,COG0644@2|Bacteria,1U3SW@1239|Firmicutes,4HSRK@91061|Bacilli	91061|Bacilli	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_3
EH1_k127_7990999_3	1266925.JHVX01000012_gene1688	1.537e-17	89.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
EH1_k127_7990999_0	1303518.CCALI_00638	3.47e-106	362.0	COG2317@1|root,COG2317@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	ypwA	-	3.4.17.19	ko:K01299,ko:K03281	-	-	-	-	ko00000,ko01000,ko01002	2.A.49	-	-	Peptidase_M32
EH1_k127_7990999_5	670487.Ocepr_1878	6.619e-05	55.0	COG1520@1|root,COG1520@2|Bacteria,1WKKN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	N	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,SBBP
EH1_k127_7993953_2	386456.JQKN01000001_gene2365	2.847e-20	94.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23NW7@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the phosphohexose mutase family	glmM2	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
EH1_k127_7993953_3	533240.CRC_02908	4.585e-14	81.0	COG2120@1|root,COG2120@2|Bacteria,1G7GT@1117|Cyanobacteria,1HSX9@1161|Nostocales	1117|Cyanobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
EH1_k127_7993953_1	518766.Rmar_0245	3.089e-85	295.0	COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes,1FIY3@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Glycosyl transferase 4-like	bshA	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
EH1_k127_7993953_4	635013.TherJR_0754	4.815e-09	69.0	COG4365@1|root,COG4365@2|Bacteria,1TQ2P@1239|Firmicutes,24DMW@186801|Clostridia,261JK@186807|Peptococcaceae	186801|Clostridia	S	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
EH1_k127_7993953_0	374847.Kcr_0092	1.144e-97	327.0	COG1167@1|root,arCOG00492@2157|Archaea	2157|Archaea	EK	PFAM Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
EH1_k127_7999154_0	635013.TherJR_1489	4.943e-220	707.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,260PA@186807|Peptococcaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
EH1_k127_7999154_4	634956.Geoth_2742	3.483e-68	237.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1WE4J@129337|Geobacillus	91061|Bacilli	G	Ribulose-phosphate 3 epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
EH1_k127_7999154_2	456320.Mvol_0133	3.488e-86	289.0	COG0176@1|root,arCOG05061@2157|Archaea,2XTET@28890|Euryarchaeota,23Q23@183939|Methanococci	183939|Methanococci	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
EH1_k127_7999154_1	662479.C440_10373	1.273e-96	335.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria	183963|Halobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
EH1_k127_7999154_3	1392491.JIAE01000001_gene1455	1.803e-72	258.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,3WHC5@541000|Ruminococcaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
EH1_k127_8036108_1	264732.Moth_0433	8.43e-19	90.0	COG1553@1|root,COG1553@2|Bacteria,1VG50@1239|Firmicutes,24R7R@186801|Clostridia,42H7U@68295|Thermoanaerobacterales	186801|Clostridia	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
EH1_k127_8036108_4	1123053.AUDG01000007_gene3189	0.0006797	48.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1WY53@135613|Chromatiales	135613|Chromatiales	P	Belongs to the DsrF TusC family	dsrF	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
EH1_k127_8036108_3	1114922.CIFAM_11_00050	0.0001026	48.0	COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,3WYQ7@544|Citrobacter	1236|Gammaproteobacteria	P	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions	tusB	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234	-	ko:K07237	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DsrH
EH1_k127_8036108_2	1220534.B655_0736	1.503e-08	62.0	COG1417@1|root,arCOG04850@2157|Archaea	2157|Archaea	S	to GB L77117 SP Q58031 PID 1591324 percent identity	-	-	-	-	-	-	-	-	-	-	-	-	DUF22
EH1_k127_8036108_0	7739.XP_002600805.1	1.705e-26	116.0	KOG0095@1|root,KOG0095@2759|Eukaryota,38CET@33154|Opisthokonta,3BEQP@33208|Metazoa,3D04X@33213|Bilateria,489CN@7711|Chordata	33208|Metazoa	U	Golgi organization	RAB30	GO:0000139,GO:0001700,GO:0002009,GO:0002165,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005795,GO:0005801,GO:0005802,GO:0006810,GO:0006996,GO:0007030,GO:0007154,GO:0007165,GO:0007264,GO:0007265,GO:0007275,GO:0007390,GO:0007391,GO:0007444,GO:0007552,GO:0007560,GO:0008150,GO:0008258,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009888,GO:0009987,GO:0010256,GO:0012505,GO:0016020,GO:0016043,GO:0016192,GO:0016331,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0023052,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0031985,GO:0032482,GO:0032501,GO:0032502,GO:0035239,GO:0035295,GO:0035556,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045202,GO:0046528,GO:0046529,GO:0048513,GO:0048563,GO:0048569,GO:0048598,GO:0048707,GO:0048729,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0060429,GO:0060562,GO:0065007,GO:0071840,GO:0097708,GO:0098588,GO:0098791	-	ko:K07917	-	-	-	-	ko00000,ko04031	-	-	-	Ras
EH1_k127_8051739_2	266264.Rmet_0710	1.171e-09	64.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,1JZZC@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglycolate phosphatase	gph	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
EH1_k127_8051739_0	485915.Dret_1495	3.193e-70	252.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42PSQ@68525|delta/epsilon subdivisions,2WKDY@28221|Deltaproteobacteria,2M8IA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
EH1_k127_8051739_1	1151117.AJLF01000002_gene104	1.234e-11	75.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,242NP@183968|Thermococci	183968|Thermococci	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
EH1_k127_8075288_3	1347393.HG726020_gene878	5.323e-10	64.0	COG0778@1|root,COG0778@2|Bacteria,4NPZV@976|Bacteroidetes,2FNIP@200643|Bacteroidia,4ANZZ@815|Bacteroidaceae	976|Bacteroidetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH1_k127_8075288_1	246194.CHY_1732	2.83e-100	340.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42I2K@68295|Thermoanaerobacterales	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
EH1_k127_8075288_0	1382356.JQMP01000003_gene1745	1.166e-109	368.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi,27YZ2@189775|Thermomicrobia	189775|Thermomicrobia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
EH1_k127_8075288_2	644281.MFS40622_0737	9.758e-16	81.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23QWX@183939|Methanococci	183939|Methanococci	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
EH1_k127_8136443_4	4920.XP_004202586.1	9.499e-13	81.0	COG1100@1|root,KOG0071@2759|Eukaryota,3A2CM@33154|Opisthokonta,3P36Y@4751|Fungi,3QVRS@4890|Ascomycota,3RUN9@4891|Saccharomycetes,47BS9@766764|Debaryomycetaceae	4751|Fungi	U	Belongs to the small GTPase superfamily. Arf family	-	-	-	ko:K07977	-	-	-	-	ko00000,ko04031	-	-	-	Arf
EH1_k127_8136443_5	633148.Tagg_0423	1.068e-12	74.0	COG1599@1|root,arCOG01510@2157|Archaea,2XQQM@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
EH1_k127_8136443_8	1121104.AQXH01000001_gene2185	8.98e-06	54.0	COG3613@1|root,COG3613@2|Bacteria	2|Bacteria	F	nucleoside 2-deoxyribosyltransferase	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
EH1_k127_8136443_2	1132509.C447_14541	2.011e-39	160.0	COG0697@1|root,arCOG00271@2157|Archaea,2XT64@28890|Euryarchaeota,23TZT@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH1_k127_8136443_0	453591.Igni_0393	1.73e-195	620.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
EH1_k127_8136443_1	679926.Mpet_2037	1.913e-76	267.0	COG1254@1|root,arCOG00643@2157|Archaea,2XVIJ@28890|Euryarchaeota	28890|Euryarchaeota	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
EH1_k127_8136443_3	1313265.JNIE01000002_gene932	2.003e-20	100.0	COG2229@1|root,COG2229@2|Bacteria,2G4BW@200783|Aquificae	200783|Aquificae	S	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1,Arf
EH1_k127_8136443_6	298654.FraEuI1c_4647	1.288e-08	66.0	COG3903@1|root,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7
EH1_k127_8136443_7	1540221.JQNI01000002_gene2562	7.399e-06	59.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
EH1_k127_8178118_0	1255043.TVNIR_0699	1.414e-74	264.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,1SZZW@1236|Gammaproteobacteria,1WXD4@135613|Chromatiales	135613|Chromatiales	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
EH1_k127_8178118_1	1236689.MMALV_14890	6.085e-74	268.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y696@28890|Euryarchaeota,3F2WC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
EH1_k127_8178118_2	401526.TcarDRAFT_1898	5.41e-35	151.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H2ME@909932|Negativicutes	909932|Negativicutes	C	PFAM FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
EH1_k127_8178118_3	52644.XP_010581064.1	2.123e-18	91.0	KOG3339@1|root,KOG3339@2759|Eukaryota,38Z55@33154|Opisthokonta,3BF7Q@33208|Metazoa,3D2TU@33213|Bilateria,48C0Y@7711|Chordata,48WUA@7742|Vertebrata,4GKSY@8782|Aves	33208|Metazoa	S	ALG14, UDP-N-acetylglucosaminyltransferase subunit	ALG14	GO:0003674,GO:0003824,GO:0004577,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006488,GO:0006490,GO:0006629,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0023052,GO:0030154,GO:0031984,GO:0032502,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045165,GO:0045168,GO:0046331,GO:0048869,GO:0070085,GO:0071704,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.141	ko:K07441	ko00510,ko00513,ko01100,map00510,map00513,map01100	M00055	R05970	-	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT1	-	Alg14
EH1_k127_8178118_4	30611.ENSOGAP00000020093	5.264e-16	84.0	COG5017@1|root,KOG3349@2759|Eukaryota,3A88H@33154|Opisthokonta,3BPCV@33208|Metazoa,3D57S@33213|Bilateria,48APN@7711|Chordata,4996B@7742|Vertebrata,3J9IW@40674|Mammalia,35F9A@314146|Euarchontoglires,4MF13@9443|Primates	33208|Metazoa	S	Glycosyltransferase family 28 C-terminal domain	Alg13	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006488,GO:0006490,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043541,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.141	ko:K07432	ko00510,ko00513,ko01100,map00510,map00513,map01100	M00055	R05970	-	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT1	-	Glyco_tran_28_C
EH1_k127_8185230_1	656519.Halsa_1020	2.259e-60	220.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,25N8F@186801|Clostridia,3WBM2@53433|Halanaerobiales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
EH1_k127_8185230_0	768710.DesyoDRAFT_1953	7.205e-112	381.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,260RG@186807|Peptococcaceae	186801|Clostridia	C	PFAM 2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
EH1_k127_8185230_2	224325.AF_0009	7.182e-58	212.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2474P@183980|Archaeoglobi	183980|Archaeoglobi	H	Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
EH1_k127_8185230_3	743719.PaelaDRAFT_3280	7.573e-56	207.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4IPQ3@91061|Bacilli,2769W@186822|Paenibacillaceae	91061|Bacilli	E	alcohol dehydrogenase	gutB	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
EH1_k127_8229136_0	720554.Clocl_1136	9.935e-130	438.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,249BI@186801|Clostridia,3WP08@541000|Ruminococcaceae	186801|Clostridia	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
EH1_k127_8229136_1	1114856.C496_20025	5.072e-32	137.0	COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,23RY4@183963|Halobacteria	183963|Halobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_8258473_2	10224.XP_006824693.1	0.0003295	51.0	COG0468@1|root,KOG1434@2759|Eukaryota,39J83@33154|Opisthokonta,3CNVJ@33208|Metazoa,3CSYZ@33213|Bilateria	33208|Metazoa	DL	strand invasion	DMC1	GO:0000003,GO:0000150,GO:0000166,GO:0000217,GO:0000228,GO:0000280,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0000781,GO:0000793,GO:0000794,GO:0001541,GO:0001556,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007059,GO:0007127,GO:0007129,GO:0007131,GO:0007140,GO:0007141,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007292,GO:0007548,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008406,GO:0008585,GO:0009314,GO:0009628,GO:0009987,GO:0009994,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019953,GO:0021700,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0030154,GO:0030554,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034622,GO:0034641,GO:0035639,GO:0035825,GO:0036094,GO:0042148,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0044703,GO:0045003,GO:0045132,GO:0045137,GO:0045143,GO:0046483,GO:0046545,GO:0046660,GO:0048232,GO:0048285,GO:0048468,GO:0048469,GO:0048477,GO:0048513,GO:0048515,GO:0048599,GO:0048608,GO:0048609,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0051276,GO:0051321,GO:0051704,GO:0051716,GO:0061458,GO:0061982,GO:0065003,GO:0065004,GO:0070013,GO:0070192,GO:0071695,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0097367,GO:0098687,GO:0098813,GO:0140013,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1903046	-	ko:K10872,ko:K19347	ko04113,map04113	-	-	-	ko00000,ko00001,ko03036,ko03400	-	-	-	HHH_5,Rad51
EH1_k127_8258473_1	1242864.D187_008172	1.689e-27	115.0	COG3602@1|root,COG3602@2|Bacteria,1MZKQ@1224|Proteobacteria,431QG@68525|delta/epsilon subdivisions,2WX2D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ACT domain	-	-	-	ko:K09964	-	-	-	-	ko00000	-	-	-	ACT_3
EH1_k127_8258473_0	1459636.NTE_00771	7.982e-34	133.0	COG1173@1|root,arCOG00749@2157|Archaea,41SFE@651137|Thaumarchaeota	651137|Thaumarchaeota	P	inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH1_k127_8265394_1	316067.Geob_1922	0.0004528	48.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH1_k127_8265394_0	406327.Mevan_0385	4e-101	344.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,23QBT@183939|Methanococci	183939|Methanococci	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
EH1_k127_8271280_2	634498.mru_1950	5.874e-22	104.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,23NQ6@183925|Methanobacteria	183925|Methanobacteria	S	Pheromone shutdown	-	-	-	-	-	-	-	-	-	-	-	-	TraB
EH1_k127_8271280_0	453591.Igni_0355	3.53e-57	206.0	COG0378@1|root,arCOG01231@2157|Archaea,2XRY5@28889|Crenarchaeota	28889|Crenarchaeota	O	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	ko:K03189,ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
EH1_k127_8271280_3	192952.MM_2042	2.614e-13	74.0	COG3355@1|root,arCOG02242@2157|Archaea,2XX1H@28890|Euryarchaeota,2NB0S@224756|Methanomicrobia	224756|Methanomicrobia	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
EH1_k127_8271280_1	69014.TK1957	7.662e-30	130.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,242VX@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	ubiA	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
EH1_k127_8271280_4	493475.GARC_4164	4.385e-10	67.0	2EE5F@1|root,33800@2|Bacteria,1R6R9@1224|Proteobacteria,1RRIQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_8307512_0	1121422.AUMW01000045_gene1210	2.438e-69	248.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260YA@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
EH1_k127_8307512_2	523850.TON_0512	7.459e-45	178.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,243T8@183968|Thermococci	183968|Thermococci	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
EH1_k127_8307512_1	1365176.N186_02405	2.706e-60	215.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
EH1_k127_8307512_3	1173023.KE650771_gene3059	8.485e-05	55.0	COG4932@1|root,COG4932@2|Bacteria,1G7U0@1117|Cyanobacteria,1JJCX@1189|Stigonemataceae	1117|Cyanobacteria	M	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
EH1_k127_8324217_1	926561.KB900617_gene1868	3.793e-51	192.0	COG0491@1|root,COG0491@2|Bacteria,1VHN6@1239|Firmicutes,24AT7@186801|Clostridia	186801|Clostridia	S	Zn-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH1_k127_8324217_2	192952.MM_0621	1.185e-21	100.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2Y507@28890|Euryarchaeota,2NB79@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
EH1_k127_8324217_0	66692.ABC1732	1.219e-66	234.0	COG1027@1|root,COG1027@2|Bacteria,1TP3U@1239|Firmicutes,4HFM9@91061|Bacilli,1ZB5F@1386|Bacillus	91061|Bacilli	E	Aspartate ammonia-lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
EH1_k127_8392234_2	891968.Anamo_0055	2.538e-07	57.0	COG0601@1|root,COG0601@2|Bacteria,3TAG1@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH1_k127_8392234_0	1303518.CCALI_00439	2.85e-104	351.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	MA20_31690	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
EH1_k127_8392234_1	572547.Amico_1777	1.35e-43	180.0	COG0747@1|root,COG0747@2|Bacteria,3TAM5@508458|Synergistetes	508458|Synergistetes	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_8395213_1	264732.Moth_0241	1.697e-07	60.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Calx-beta,DUF11,DUF1573,F5_F8_type_C,FG-GAP,Glyco_hyd_101C,Glyco_hydro_101,NPCBM_assoc,SASA
EH1_k127_8395213_0	641524.ADICYQ_4137	1.172e-22	113.0	2DDE1@1|root,2ZHNZ@2|Bacteria,4NNSM@976|Bacteroidetes,47UJY@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
EH1_k127_8411365_2	415426.Hbut_0268	9.509e-19	93.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRIJ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_8411365_0	264732.Moth_1918	1.044e-213	679.0	COG1061@1|root,COG1061@2|Bacteria,1TPDM@1239|Firmicutes,24CK8@186801|Clostridia	186801|Clostridia	KL	Helicase conserved C-terminal domain	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
EH1_k127_8411365_1	490899.DKAM_0206	9.06e-30	129.0	COG0467@1|root,arCOG05482@2157|Archaea,2XQX8@28889|Crenarchaeota	28889|Crenarchaeota	T	COGs COG0467 RecA-superfamily ATPase implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
EH1_k127_8425817_3	439235.Dalk_1327	3.274e-08	62.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
EH1_k127_8425817_0	374847.Kcr_0737	1.092e-56	208.0	COG0476@1|root,arCOG01676@2157|Archaea	2157|Archaea	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	TBP,ThiF,ThiS
EH1_k127_8425817_1	7425.NV16204-PA	1.167e-15	82.0	COG5133@1|root,KOG3381@2759|Eukaryota,3A1NG@33154|Opisthokonta,3BQM5@33208|Metazoa,3D4ZQ@33213|Bilateria,41Z6Z@6656|Arthropoda,3SKXE@50557|Insecta,46IBJ@7399|Hymenoptera	33208|Metazoa	S	Iron-sulfur cluster assembly protein	FAM96B	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0006790,GO:0007059,GO:0008150,GO:0008152,GO:0009987,GO:0015630,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0031974,GO:0031981,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0051186,GO:0070013,GO:0071817,GO:0071840,GO:0097361	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
EH1_k127_8425817_2	269797.Mbar_A0957	2.454e-14	78.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2NA25@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
EH1_k127_8426636_0	555088.DealDRAFT_2538	3.412e-221	696.0	COG1960@1|root,COG1960@2|Bacteria,1V03D@1239|Firmicutes,24A8N@186801|Clostridia	186801|Clostridia	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
EH1_k127_8426636_6	1487923.DP73_06490	1.472e-13	72.0	COG1146@1|root,COG1146@2|Bacteria,1W2AI@1239|Firmicutes,25709@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
EH1_k127_8426636_3	1121468.AUBR01000028_gene1506	5.994e-46	178.0	COG1149@1|root,COG1149@2|Bacteria,1VDSQ@1239|Firmicutes,24NTS@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH1_k127_8426636_5	1121353.H924_08445	1.163e-13	77.0	COG1249@1|root,COG1249@2|Bacteria,2GNSR@201174|Actinobacteria,22JKS@1653|Corynebacteriaceae	201174|Actinobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	mtr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0010126,GO:0016137,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050627,GO:0050660,GO:0050661,GO:0050662,GO:0051186,GO:0055114,GO:0070402,GO:0071704,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901657	1.8.1.15	ko:K17883	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
EH1_k127_8426636_1	391623.TERMP_00490	9.371e-175	568.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,242P8@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
EH1_k127_8426636_2	1379698.RBG1_1C00001G0675	1.403e-100	340.0	COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lysDH	-	1.4.1.18	ko:K19064	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R00446,R02317	RC00062,RC00694	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
EH1_k127_8426636_4	1293054.HSACCH_00395	1.101e-35	140.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
EH1_k127_8443075_4	351160.RCIX86	7.539e-63	233.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia	224756|Methanomicrobia	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH1_k127_8443075_3	1259795.ARJK01000002_gene28	1.386e-96	327.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,25J0X@186801|Clostridia,42F6Z@68295|Thermoanaerobacterales	186801|Clostridia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
EH1_k127_8443075_5	511051.CSE_09390	4.181e-18	87.0	2C539@1|root,33HA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH1_k127_8443075_1	498848.TaqDRAFT_4226	1.218e-142	470.0	COG0318@1|root,COG0318@2|Bacteria,1WIAG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
EH1_k127_8443075_0	572478.Vdis_0258	5.39e-197	634.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
EH1_k127_8443075_2	986075.CathTA2_1447	4.748e-115	384.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4HASW@91061|Bacilli	91061|Bacilli	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
EH1_k127_8443075_6	580340.Tlie_0403	4.412e-16	79.0	COG0346@1|root,COG0346@2|Bacteria,3TAXT@508458|Synergistetes	508458|Synergistetes	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
EH1_k127_8443860_1	1380391.JIAS01000004_gene2960	3.269e-06	57.0	COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2TS4U@28211|Alphaproteobacteria,2JP86@204441|Rhodospirillales	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH1_k127_8443860_0	1304874.JAFY01000002_gene134	1.048e-75	273.0	COG1173@1|root,COG1173@2|Bacteria,3T9XU@508458|Synergistetes	508458|Synergistetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH1_k127_8474503_3	224325.AF_0965	8.932e-10	69.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y3J3@28890|Euryarchaeota,24718@183980|Archaeoglobi	183980|Archaeoglobi	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
EH1_k127_8474503_0	273075.Ta0351	1.436e-69	251.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
EH1_k127_8474503_2	1220534.B655_1002	4.487e-11	77.0	arCOG02498@1|root,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	NosD
EH1_k127_8474503_1	926569.ANT_22340	9.915e-28	120.0	COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi	200795|Chloroflexi	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
EH1_k127_8476744_1	439481.Aboo_0721	5.365e-11	65.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,3F31M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH1_k127_8476744_0	517418.Ctha_0236	4.911e-22	113.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	cspBA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
EH1_k127_852448_2	1499967.BAYZ01000028_gene1366	1.241e-70	245.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
EH1_k127_852448_3	1120959.ATXF01000006_gene1866	1.058e-37	153.0	COG2021@1|root,COG2021@2|Bacteria,2IMKC@201174|Actinobacteria,4FQP1@85023|Microbacteriaceae	201174|Actinobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
EH1_k127_852448_1	1313304.CALK_0001	9.668e-104	352.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH1_k127_852448_0	1121422.AUMW01000009_gene3340	0.0	1062.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
EH1_k127_852448_4	1227454.C446_18166	1.251e-17	92.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
EH1_k127_852448_5	357808.RoseRS_0760	4.4e-15	84.0	COG0526@1|root,COG0526@2|Bacteria,2G737@200795|Chloroflexi,375V3@32061|Chloroflexia	32061|Chloroflexia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DnaJ
EH1_k127_852448_6	883078.HMPREF9695_00868	5.713e-10	68.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,3JVFP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Cytochrome c biogenesis protein	soxV	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
EH1_k127_872349_0	1173027.Mic7113_3386	5.862e-56	216.0	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
EH1_k127_872349_2	1386089.N865_10560	2.176e-05	55.0	COG3832@1|root,COG3832@2|Bacteria,2HY31@201174|Actinobacteria,4FJKG@85021|Intrasporangiaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
EH1_k127_872349_1	1033810.HLPCO_001860	3.997e-07	61.0	COG0170@1|root,COG0170@2|Bacteria,2NRZ0@2323|unclassified Bacteria	2|Bacteria	I	dolichyl monophosphate biosynthetic process	sec59	GO:0003674,GO:0003824,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0006766,GO:0006775,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009987,GO:0010189,GO:0010276,GO:0016101,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017144,GO:0018130,GO:0033306,GO:0034308,GO:0042360,GO:0042362,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1903173	2.7.1.182	ko:K18678	-	-	R10659	RC00002,RC00017	ko00000,ko01000	-	-	-	DUF92
EH1_k127_879904_0	1313172.YM304_09780	1.763e-07	64.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	PE
EH1_k127_90521_1	710696.Intca_3130	9.688e-49	179.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4FJQG@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
EH1_k127_90521_0	374847.Kcr_1556	2.542e-65	238.0	COG0624@1|root,arCOG01107@2157|Archaea	2157|Archaea	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
EH1_k127_90521_2	1160718.SU9_22635	2.644e-33	139.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
EH1_k127_90521_4	9767.XP_007175422.1	4.986e-18	92.0	KOG0443@1|root,KOG0443@2759|Eukaryota,38QM1@33154|Opisthokonta,3B9JY@33208|Metazoa,3D0D6@33213|Bilateria,47YVF@7711|Chordata,48X58@7742|Vertebrata,3J3W1@40674|Mammalia,4J1PR@91561|Cetartiodactyla	33208|Metazoa	Z	Capping actin protein, gelsolin like	CAPG	GO:0002376,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0005815,GO:0005819,GO:0005856,GO:0006950,GO:0006952,GO:0006955,GO:0008064,GO:0008150,GO:0008290,GO:0009987,GO:0010033,GO:0010639,GO:0015629,GO:0015630,GO:0016043,GO:0019904,GO:0022607,GO:0030030,GO:0030031,GO:0030139,GO:0030496,GO:0030832,GO:0030833,GO:0030834,GO:0030835,GO:0030837,GO:0031333,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0032271,GO:0032272,GO:0032535,GO:0032956,GO:0032970,GO:0032991,GO:0033043,GO:0034097,GO:0034341,GO:0042221,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043242,GO:0043244,GO:0043254,GO:0043933,GO:0044085,GO:0044087,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044450,GO:0044464,GO:0044877,GO:0045087,GO:0045335,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051016,GO:0051128,GO:0051129,GO:0051493,GO:0051494,GO:0051693,GO:0051716,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070887,GO:0071310,GO:0071345,GO:0071346,GO:0071840,GO:0072686,GO:0090066,GO:0090543,GO:0097708,GO:0110053,GO:1901879,GO:1901880,GO:1902903,GO:1902904	-	ko:K10368	-	-	-	-	ko00000,ko04147,ko04812	-	-	-	Gelsolin
EH1_k127_90521_3	456442.Mboo_0505	3.117e-22	101.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH1_k127_918629_0	926569.ANT_18640	3.574e-99	331.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
EH1_k127_918629_1	225117.XP_009350218.1	6.257e-10	72.0	KOG0094@1|root,KOG0094@2759|Eukaryota,37QK7@33090|Viridiplantae,3G9XA@35493|Streptophyta,4JK48@91835|fabids	33090|Viridiplantae	U	Ras-related protein	-	-	-	ko:K07893	-	-	-	-	ko00000,ko04031,ko04131,ko04147	-	-	-	Ras
EH1_k127_918629_3	7244.FBpp0232124	1.303e-05	55.0	COG4886@1|root,KOG0619@2759|Eukaryota,KOG4641@2759|Eukaryota,39WAB@33154|Opisthokonta,3BN8H@33208|Metazoa,3D2S8@33213|Bilateria,41X4B@6656|Arthropoda,3SK89@50557|Insecta,451UW@7147|Diptera,45VA2@7214|Drosophilidae	33208|Metazoa	S	Leucine Rich repeat	-	GO:0000902,GO:0000904,GO:0001558,GO:0002020,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006935,GO:0007275,GO:0007399,GO:0007423,GO:0007444,GO:0008037,GO:0008038,GO:0008056,GO:0008150,GO:0009605,GO:0009653,GO:0009888,GO:0009987,GO:0010720,GO:0010769,GO:0010770,GO:0010975,GO:0010976,GO:0016020,GO:0016043,GO:0016358,GO:0019899,GO:0022008,GO:0022603,GO:0022604,GO:0030030,GO:0030154,GO:0030182,GO:0030425,GO:0031175,GO:0031252,GO:0031253,GO:0031256,GO:0031344,GO:0031346,GO:0032501,GO:0032502,GO:0032589,GO:0032590,GO:0032989,GO:0032990,GO:0035214,GO:0035295,GO:0036477,GO:0040008,GO:0040011,GO:0042221,GO:0042330,GO:0042995,GO:0043005,GO:0044425,GO:0044459,GO:0044463,GO:0044464,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048638,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048813,GO:0048814,GO:0048856,GO:0048858,GO:0048869,GO:0050767,GO:0050769,GO:0050773,GO:0050775,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051128,GO:0051130,GO:0051239,GO:0051240,GO:0051960,GO:0051962,GO:0060284,GO:0060429,GO:0065007,GO:0070593,GO:0070983,GO:0071840,GO:0071944,GO:0097447,GO:0097458,GO:0097485,GO:0098590,GO:0120025,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:1900006,GO:1903859,GO:2000026	-	ko:K13023	-	-	-	-	ko00000,ko01002	-	-	-	LRR_6,LRR_8
EH1_k127_918629_2	649638.Trad_2143	1.127e-07	65.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Metallophos
EH1_k127_940739_0	1121472.AQWN01000011_gene1255	2.629e-153	497.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,26167@186807|Peptococcaceae	186801|Clostridia	C	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
EH1_k127_940739_3	273068.TTE2383	4.667e-16	86.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,42GW2@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM Biotin lipoyl attachment	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
EH1_k127_940739_1	679926.Mpet_0551	1.095e-86	300.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
EH1_k127_940739_4	224325.AF_1292	5.493e-06	53.0	COG1545@1|root,arCOG01285@2157|Archaea,2XYBD@28890|Euryarchaeota	28890|Euryarchaeota	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
EH1_k127_940739_2	1274524.BSONL12_05683	6.442e-82	287.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HAWZ@91061|Bacilli,1ZCGC@1386|Bacillus	91061|Bacilli	I	acyl-CoA dehydrogenase	yngJ	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
EH1_k127_957271_4	70601.3257011	1.342e-31	128.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,24423@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
EH1_k127_957271_6	415426.Hbut_1085	3.871e-19	93.0	COG2412@1|root,arCOG04051@2157|Archaea,2XR9B@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
EH1_k127_957271_5	572546.Arcpr_0696	1.462e-27	125.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2464I@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
EH1_k127_957271_3	647113.Metok_1149	6.919e-32	128.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23QZQ@183939|Methanococci	183939|Methanococci	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
EH1_k127_957271_0	351160.LRC287	5.647e-59	214.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
EH1_k127_957271_2	604354.TSIB_1106	7.222e-44	166.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,24319@183968|Thermococci	183968|Thermococci	J	Pfam:KH_3	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
EH1_k127_957271_1	1006006.Mcup_0475	1.316e-55	206.0	COG1389@1|root,arCOG01165@2157|Archaea,2XPVY@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	FbpA,HATPase_c,HATPase_c_3,Topo-VIb_trans
EH1_k127_970498_0	1444309.JAQG01000157_gene3280	6.843e-10	67.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,4HBYM@91061|Bacilli,26S4B@186822|Paenibacillaceae	91061|Bacilli	L	8-oxoguanine DNA glycosylase	yfjP	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
## 2196 queries scanned
## Total time (seconds): 56.14259576797485
## Rate: 39.11 q/s