## Sat Nov 16 05:14:33 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin2/EH_3_bin.30.fa -m mmseqs --itype genome -o EH_3_bin.30 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/EH_3_bin.30 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
EH3_k127_1035198_3	518766.Rmar_1488	3.561e-39	149.0	COG1313@1|root,COG1313@2|Bacteria	2|Bacteria	C	radical SAM domain protein	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
EH3_k127_1035198_6	1122611.KB903987_gene3955	2.362e-11	76.0	COG1670@1|root,COG1670@2|Bacteria,2H4AD@201174|Actinobacteria,4EJIU@85012|Streptosporangiales	201174|Actinobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1035198_2	526225.Gobs_3538	1.831e-45	168.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4ETQ3@85013|Frankiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
EH3_k127_1035198_0	1144312.PMI09_04985	2.432e-227	744.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,Guanylate_cyc,SAM_1,SAM_2,TPR_12,TPR_4
EH3_k127_1035198_8	518766.Rmar_2901	0.0005322	47.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
EH3_k127_1035198_4	237368.SCABRO_01150	9.536e-33	133.0	COG1487@1|root,COG1487@2|Bacteria,2J1EF@203682|Planctomycetes	203682|Planctomycetes	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
EH3_k127_1035198_1	479431.Namu_0826	5.313e-178	566.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4ERYT@85013|Frankiales	201174|Actinobacteria	L	DNA ligase	ligC	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
EH3_k127_1035198_7	1120948.KB903217_gene1523	1.816e-06	53.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria,4E5GS@85010|Pseudonocardiales	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
EH3_k127_1035198_5	515635.Dtur_0951	3.494e-30	130.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
EH3_k127_1077942_7	197221.22294316	5.491e-45	170.0	COG0606@1|root,COG0606@2|Bacteria,1G0K1@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM Magnesium chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
EH3_k127_1077942_0	1267534.KB906754_gene3508	1.149e-192	620.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
EH3_k127_1077942_6	479431.Namu_3507	1.41e-47	186.0	COG1392@1|root,COG1392@2|Bacteria,2IIE4@201174|Actinobacteria	201174|Actinobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
EH3_k127_1077942_1	1123258.AQXZ01000016_gene2438	5.599e-103	348.0	COG0306@1|root,COG0306@2|Bacteria,2GJHK@201174|Actinobacteria,4FW14@85025|Nocardiaceae	201174|Actinobacteria	P	Phosphate transporter family	pitB	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	iNJ661.Rv2281	PHO4
EH3_k127_1077942_12	1125863.JAFN01000001_gene2289	4.027e-26	111.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
EH3_k127_1077942_9	478801.Ksed_11130	1.42e-32	128.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,1ZW2U@145357|Dermacoccaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
EH3_k127_1077942_3	1869.MB27_36785	1.484e-58	210.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4DA93@85008|Micromonosporales	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
EH3_k127_1077942_8	1380347.JNII01000007_gene752	2.163e-42	168.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4ESKU@85013|Frankiales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
EH3_k127_1077942_5	994479.GL877878_gene404	1.318e-49	183.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4E3E1@85010|Pseudonocardiales	201174|Actinobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
EH3_k127_1077942_2	1160707.AJIK01000004_gene1206	3.215e-77	264.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26D2R@186818|Planococcaceae	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
EH3_k127_1077942_11	1194972.MVAC_17098	2.042e-27	121.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,238SB@1762|Mycobacteriaceae	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
EH3_k127_1077942_13	1235797.C816_01848	1.246e-16	85.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,2N7N7@216572|Oscillospiraceae	186801|Clostridia	S	KH domain	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
EH3_k127_1077942_10	592015.HMPREF1705_00188	2.255e-31	126.0	COG0228@1|root,COG0228@2|Bacteria,3TBDH@508458|Synergistetes	508458|Synergistetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
EH3_k127_1077942_4	1121441.AUCX01000010_gene257	7.559e-56	200.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2M8JZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
EH3_k127_107836_0	1121017.AUFG01000019_gene2375	3.514e-111	370.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4FINF@85021|Intrasporangiaceae	201174|Actinobacteria	H	Elongator protein 3, MiaB family, Radical SAM	fbiC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
EH3_k127_107836_1	1054860.KB913030_gene2473	5.905e-81	281.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
EH3_k127_1174846_2	243230.DR_0987	1.322e-49	184.0	COG2197@1|root,COG2197@2|Bacteria,1WI4W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
EH3_k127_1174846_4	521096.Tpau_1009	3.867e-15	88.0	COG2197@1|root,COG2197@2|Bacteria,2GMUG@201174|Actinobacteria	201174|Actinobacteria	T	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
EH3_k127_1174846_3	443143.GM18_1089	2.287e-25	120.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X6YR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,Response_reg,dCache_1
EH3_k127_1174846_0	926690.KE386573_gene2078	1.956e-79	283.0	COG1120@1|root,arCOG00199@2157|Archaea,2XTTV@28890|Euryarchaeota,23SRW@183963|Halobacteria	183963|Halobacteria	E	COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components	btuD	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
EH3_k127_1174846_1	1289387.AUKW01000014_gene3422	2.487e-76	269.0	COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
EH3_k127_1203728_10	42256.RradSPS_2904	2.057e-46	192.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,4CTVZ@84995|Rubrobacteria	84995|Rubrobacteria	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Phosphoesterase
EH3_k127_1203728_16	1385519.N801_03035	1.016e-06	57.0	COG2085@1|root,COG2085@2|Bacteria,2GMN3@201174|Actinobacteria,4FJWG@85021|Intrasporangiaceae	201174|Actinobacteria	S	NADP oxidoreductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
EH3_k127_1203728_8	1297742.A176_03404	4.147e-79	287.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM ROK family protein	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
EH3_k127_1203728_11	644966.Tmar_0126	7.523e-46	188.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1V33I@1239|Firmicutes	1239|Firmicutes	IM	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.7.74,2.7.8.34	ko:K07281,ko:K07291	ko00562,map00562	-	R09669,R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,NTP_transf_3
EH3_k127_1203728_2	477641.MODMU_3653	1.336e-127	420.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4EV33@85013|Frankiales	201174|Actinobacteria	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH3_k127_1203728_14	177437.HRM2_48610	5.12e-25	110.0	COG1028@1|root,COG3427@1|root,COG1028@2|Bacteria,COG3427@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2MIUD@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2,adh_short
EH3_k127_1203728_7	1120934.KB894415_gene3946	2.499e-80	282.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4E0AR@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
EH3_k127_1203728_6	589865.DaAHT2_2619	8.094e-84	286.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,42R9G@68525|delta/epsilon subdivisions,2WMTN@28221|Deltaproteobacteria,2MMGZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
EH3_k127_1203728_13	351607.Acel_1448	3.709e-34	134.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,2GIV9@201174|Actinobacteria,4EXEH@85013|Frankiales	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_1203728_0	402881.Plav_3090	6.561e-167	541.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2U3DK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
EH3_k127_1203728_12	543632.JOJL01000038_gene3143	3.22e-43	176.0	COG4447@1|root,COG4447@2|Bacteria,2IT8P@201174|Actinobacteria	201174|Actinobacteria	M	phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1203728_1	1380347.JNII01000012_gene2641	5.314e-139	457.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
EH3_k127_1203728_9	930171.Asphe3_29930	5.939e-52	195.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
EH3_k127_1203728_4	35754.JNYJ01000042_gene1350	3.897e-103	344.0	COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria,4DMD2@85008|Micromonosporales	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran,DUF4162
EH3_k127_1203728_3	1380390.JIAT01000001_gene5080	1.807e-108	367.0	COG0665@1|root,COG0665@2|Bacteria,2IEZA@201174|Actinobacteria,4CRMC@84995|Rubrobacteria	84995|Rubrobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_1203728_15	1120950.KB892782_gene296	5.197e-20	99.0	COG0346@1|root,COG0346@2|Bacteria,2IN2S@201174|Actinobacteria,4DVTH@85009|Propionibacteriales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
EH3_k127_1203728_5	1294143.H681_16500	1.931e-97	335.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_1227791_7	316067.Geob_3458	2.377e-07	54.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,42RID@68525|delta/epsilon subdivisions,2WN9N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase U62 modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH3_k127_1227791_2	1313172.YM304_10970	2.479e-69	244.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
EH3_k127_1227791_3	713587.THITH_05975	1.036e-47	177.0	COG5573@1|root,COG5573@2|Bacteria,1RKIK@1224|Proteobacteria,1SBYM@1236|Gammaproteobacteria,1WZ8S@135613|Chromatiales	135613|Chromatiales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
EH3_k127_1227791_6	429009.Adeg_1039	6.186e-12	74.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,42H14@68295|Thermoanaerobacterales	186801|Clostridia	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
EH3_k127_1227791_0	643648.Slip_0897	2.273e-106	356.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42JJA@68298|Syntrophomonadaceae	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
EH3_k127_1227791_5	754252.PFREUD_18020	8.972e-19	99.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria	201174|Actinobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
EH3_k127_1227791_1	246194.CHY_2582	2.608e-102	349.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,42EY9@68295|Thermoanaerobacterales	186801|Clostridia	M	TIGRFAM UTP--glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
EH3_k127_1227791_4	67275.JOAP01000009_gene3867	1.673e-19	97.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria	201174|Actinobacteria	H	Molybdenum cofactor synthesis domain protein	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
EH3_k127_1351279_3	1121877.JQKF01000003_gene1461	4.03e-107	354.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CMWQ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
EH3_k127_1351279_4	1306174.JODP01000016_gene7064	2.267e-56	204.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria	201174|Actinobacteria	E	Acetolactate synthase	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
EH3_k127_1351279_2	479434.Sthe_1555	5.826e-137	443.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi,27XV8@189775|Thermomicrobia	189775|Thermomicrobia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
EH3_k127_1351279_0	525909.Afer_1529	3.181e-175	563.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4CNJW@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
EH3_k127_1351279_1	335543.Sfum_2989	6.567e-140	454.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2MR26@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
EH3_k127_1491702_10	1210884.HG799463_gene9434	1.556e-19	104.0	COG1524@1|root,COG1524@2|Bacteria,2J1VF@203682|Planctomycetes	203682|Planctomycetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
EH3_k127_1491702_9	585502.HMPREF0645_1477	4.583e-20	106.0	COG1524@1|root,COG1524@2|Bacteria,4NE94@976|Bacteroidetes,2FMQC@200643|Bacteroidia	976|Bacteroidetes	P	type I phosphodiesterase nucleotide pyrophosphatase	pafA	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
EH3_k127_1491702_11	1210884.HG799463_gene9434	2.066e-17	96.0	COG1524@1|root,COG1524@2|Bacteria,2J1VF@203682|Planctomycetes	203682|Planctomycetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
EH3_k127_1491702_13	253839.SSNG_05355	0.0002109	53.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria	201174|Actinobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
EH3_k127_1491702_5	543632.JOJL01000042_gene4660	2.76e-53	201.0	COG0701@1|root,COG0701@2|Bacteria,2GJQ0@201174|Actinobacteria,4D9HD@85008|Micromonosporales	201174|Actinobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
EH3_k127_1491702_12	316274.Haur_1695	6.553e-10	71.0	COG3689@1|root,COG3689@2|Bacteria,2G73M@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF1980)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1980
EH3_k127_1491702_7	1229780.BN381_100221	7.5e-26	122.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
EH3_k127_1491702_1	479435.Kfla_2457	6.411e-60	226.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,4DPI0@85009|Propionibacteriales	201174|Actinobacteria	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
EH3_k127_1491702_3	1386089.N865_16990	1.261e-58	212.0	COG1121@1|root,COG1121@2|Bacteria,2GP3A@201174|Actinobacteria,4FFIB@85021|Intrasporangiaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	mntB	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
EH3_k127_1491702_0	446466.Cfla_2183	4.592e-79	275.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4F23Y@85016|Cellulomonadaceae	201174|Actinobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
EH3_k127_1491702_8	312284.A20C1_10214	1.316e-25	110.0	COG1725@1|root,COG1725@2|Bacteria,2IQEW@201174|Actinobacteria,3UWUM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR
EH3_k127_1491702_2	1078020.KEK_14703	9.772e-60	220.0	COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria,234CU@1762|Mycobacteriaceae	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH3_k127_1491702_6	1236902.ANAS01000025_gene455	1.607e-31	143.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4EH36@85012|Streptosporangiales	201174|Actinobacteria	M	D-Ala-D-Ala carboxypeptidase 3 (S13) family	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
EH3_k127_1491702_4	42256.RradSPS_1835	4.528e-55	212.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CRIR@84995|Rubrobacteria	84995|Rubrobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
EH3_k127_1524322_3	42256.RradSPS_2494	1.88e-09	63.0	COG0589@1|root,COG0589@2|Bacteria,2HR8H@201174|Actinobacteria,4CT4U@84995|Rubrobacteria	84995|Rubrobacteria	T	COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms	-	-	-	-	-	-	-	-	-	-	-	-	Usp
EH3_k127_1524322_0	1382356.JQMP01000003_gene1584	1.196e-309	972.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
EH3_k127_1524322_1	1048834.TC41_2887	2.052e-26	117.0	COG4097@1|root,COG4097@2|Bacteria,1VAMR@1239|Firmicutes,4HKN3@91061|Bacilli	91061|Bacilli	P	Ferric reductase like transmembrane component	-	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
EH3_k127_1524322_2	68219.JNXI01000010_gene5736	1.357e-20	96.0	COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
EH3_k127_1540471_1	710687.KI912270_gene4527	8.258e-112	381.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2I2WW@201174|Actinobacteria,23FHB@1762|Mycobacteriaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_1540471_0	1122138.AQUZ01000056_gene6929	8.258e-114	370.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4DPH5@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
EH3_k127_1540471_3	1120949.KB903326_gene3159	2.279e-69	244.0	2DN8B@1|root,32W2U@2|Bacteria,2ISPU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1540471_9	1120949.KB903294_gene4318	1.986e-28	128.0	COG0640@1|root,COG0640@2|Bacteria,2ISNZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
EH3_k127_1540471_8	675635.Psed_4075	5.434e-42	163.0	COG3832@1|root,COG3832@2|Bacteria,2GQIZ@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
EH3_k127_1540471_4	1001240.GY21_04735	1.248e-64	224.0	2AKGE@1|root,31B89@2|Bacteria,2IN2E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1540471_11	1382303.JPOM01000001_gene262	0.0002875	51.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,2U6YA@28211|Alphaproteobacteria,2KGUX@204458|Caulobacterales	204458|Caulobacterales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
EH3_k127_1540471_5	58344.JOEL01000010_gene5721	1.737e-55	201.0	COG1670@1|root,COG1670@2|Bacteria,2GNYE@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferases including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
EH3_k127_1540471_7	1382306.JNIM01000001_gene535	9.258e-49	188.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
EH3_k127_1540471_10	1283283.ATXA01000001_gene487	1.607e-21	100.0	COG3795@1|root,COG3795@2|Bacteria	2|Bacteria	F	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2,YCII
EH3_k127_1540471_2	1463920.JOGB01000002_gene3215	1.404e-78	269.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
EH3_k127_1540471_6	1179773.BN6_84170	3.091e-55	204.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4DYBZ@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
EH3_k127_1580395_8	298655.KI912266_gene120	0.0004386	52.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4ERMX@85013|Frankiales	201174|Actinobacteria	K	Response regulator receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
EH3_k127_1580395_6	1156844.KB891801_gene2764	3.625e-10	66.0	COG2919@1|root,COG2919@2|Bacteria,2GQH7@201174|Actinobacteria	201174|Actinobacteria	D	septum formation initiator	divIC	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
EH3_k127_1580395_1	1114959.SZMC14600_03012	5.276e-182	578.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4DXDR@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
EH3_k127_1580395_4	378806.STAUR_4845	1.575e-19	92.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,Acetyltransf_9,DUF952
EH3_k127_1580395_7	1120934.KB894441_gene5681	1.685e-05	57.0	COG0454@1|root,COG0454@2|Bacteria,2IDJQ@201174|Actinobacteria	201174|Actinobacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH3_k127_1580395_5	1151122.AQYD01000007_gene510	2.596e-15	84.0	COG0671@1|root,COG0671@2|Bacteria,2HPG8@201174|Actinobacteria,4FNPW@85023|Microbacteriaceae	201174|Actinobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
EH3_k127_1580395_2	1235835.C814_00747	3.226e-66	235.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,3WHY1@541000|Ruminococcaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
EH3_k127_1580395_3	938293.CAJU020000016_gene1664	7.787e-27	126.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,22H08@1570339|Peptoniphilaceae	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
EH3_k127_1580395_0	1463856.JOHY01000006_gene201	1.916e-296	943.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
EH3_k127_158205_1	391037.Sare_4810	4.966e-74	275.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,2GMG7@201174|Actinobacteria,4DDUD@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR,MerR_1
EH3_k127_158205_2	1122182.KB903835_gene4485	7.751e-16	85.0	COG1595@1|root,COG1595@2|Bacteria,2IHVZ@201174|Actinobacteria,4DDW8@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_158205_0	285535.JOEY01000056_gene6770	2.289e-131	428.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria	201174|Actinobacteria	G	family 4	-	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
EH3_k127_1662998_1	471852.Tcur_3392	1.031e-169	544.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4EFKQ@85012|Streptosporangiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_1662998_3	1283299.AUKG01000002_gene5276	9.826e-115	379.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4CR0F@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH3_k127_1662998_2	1499967.BAYZ01000028_gene1366	4.488e-115	395.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
EH3_k127_1662998_0	880073.Calab_0341	6.377e-238	745.0	COG2986@1|root,COG2986@2|Bacteria,2NQHF@2323|unclassified Bacteria	2|Bacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
EH3_k127_1662998_5	1463901.JOIY01000035_gene6961	5.683e-66	233.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
EH3_k127_1662998_4	768706.Desor_5053	1.305e-93	330.0	COG5598@1|root,COG5598@2|Bacteria,1UYBQ@1239|Firmicutes,249D7@186801|Clostridia,260FT@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
EH3_k127_1662998_6	365528.KB891263_gene641	2.349e-41	159.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4ERPB@85013|Frankiales	201174|Actinobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
EH3_k127_1704395_20	1236902.ANAS01000024_gene3166	6.769e-07	56.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria,4EPZI@85012|Streptosporangiales	201174|Actinobacteria	CO	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
EH3_k127_1704395_14	1122933.JNIY01000003_gene783	1.129e-18	89.0	COG0526@1|root,COG0526@2|Bacteria,2IR6C@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
EH3_k127_1704395_11	429009.Adeg_1599	6.25e-38	158.0	COG1322@1|root,COG1322@2|Bacteria	2|Bacteria	S	DNA recombination	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	Apolipoprotein,RmuC
EH3_k127_1704395_17	285535.JOEY01000004_gene10062	3.13e-10	68.0	COG3868@1|root,COG3868@2|Bacteria,2GM86@201174|Actinobacteria	201174|Actinobacteria	MU	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_114
EH3_k127_1704395_3	1896.JOAU01000001_gene4534	1.219e-79	273.0	COG3868@1|root,COG3868@2|Bacteria,2GM86@201174|Actinobacteria	201174|Actinobacteria	MU	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_114
EH3_k127_1704395_10	246197.MXAN_3222	2.546e-38	149.0	COG0454@1|root,COG0456@2|Bacteria,1N9KA@1224|Proteobacteria,431PF@68525|delta/epsilon subdivisions,2WW76@28221|Deltaproteobacteria,2Z1KC@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
EH3_k127_1704395_18	391613.RTM1035_05500	1.002e-09	67.0	COG3450@1|root,COG3450@2|Bacteria,1N1GM@1224|Proteobacteria,2UIF2@28211|Alphaproteobacteria,46Q7K@74030|Roseovarius	28211|Alphaproteobacteria	S	Protein of unknown function (DUF861)	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
EH3_k127_1704395_7	357808.RoseRS_3403	4.253e-62	221.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi,375NK@32061|Chloroflexia	32061|Chloroflexia	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
EH3_k127_1704395_13	644283.Micau_5425	5.133e-27	116.0	2DHRC@1|root,32U9K@2|Bacteria,2II2K@201174|Actinobacteria,4DM9E@85008|Micromonosporales	201174|Actinobacteria	S	Family of unknown function (DUF5319)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5319
EH3_k127_1704395_1	1035308.AQYY01000001_gene3210	4.776e-142	485.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1TSAC@1239|Firmicutes,25EIJ@186801|Clostridia,261GW@186807|Peptococcaceae	186801|Clostridia	L	Eukaryotic and archaeal DNA primase small subunit	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
EH3_k127_1704395_4	35754.JNYJ01000038_gene4979	7.424e-78	273.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4D9ZY@85008|Micromonosporales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
EH3_k127_1704395_12	485913.Krac_3201	1.464e-36	153.0	COG0454@1|root,COG0456@2|Bacteria,2G6N6@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH3_k127_1704395_6	1380370.JIBA01000012_gene3446	1.798e-62	231.0	COG3832@1|root,COG3832@2|Bacteria,2IBWM@201174|Actinobacteria,4FGG3@85021|Intrasporangiaceae	201174|Actinobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1704395_8	443143.GM18_0267	7.222e-59	215.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
EH3_k127_1704395_5	1115632.JAFW01000001_gene4529	1.041e-65	233.0	COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,1WBSU@1268|Micrococcaceae	201174|Actinobacteria	S	Hydrolase of the alpha beta-hydrolase	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	DLH
EH3_k127_1704395_16	471852.Tcur_3898	1.224e-12	72.0	2E3EP@1|root,32YDP@2|Bacteria,2GQST@201174|Actinobacteria,4EKFS@85012|Streptosporangiales	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1704395_0	526227.Mesil_1980	5.143e-168	542.0	COG3303@1|root,COG3303@2|Bacteria,1WI15@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
EH3_k127_1704395_9	452637.Oter_4607	2.701e-52	191.0	COG3005@1|root,COG3005@2|Bacteria,46T0N@74201|Verrucomicrobia,3K8D9@414999|Opitutae	414999|Opitutae	C	TIGRFAM cytochrome c nitrate reductase, small subunit	-	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
EH3_k127_1704395_19	1034347.CAHJ01000081_gene1362	2.169e-09	64.0	2DGVU@1|root,2ZXGD@2|Bacteria,1W2UG@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1704395_15	1048339.KB913029_gene974	1.72e-15	89.0	COG0406@1|root,COG0406@2|Bacteria,2GM22@201174|Actinobacteria	201174|Actinobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
EH3_k127_1704395_21	485913.Krac_0968	0.0001816	53.0	COG2318@1|root,COG2318@2|Bacteria,2G92D@200795|Chloroflexi	2|Bacteria	S	SPTR D1C1B9 DinB family protein	dinB	-	-	-	-	-	-	-	-	-	-	-	DUF664,DinB
EH3_k127_1704395_2	196162.Noca_1635	1.077e-88	298.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria,4DP6H@85009|Propionibacteriales	201174|Actinobacteria	F	Amidohydrolase family	hyuA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
EH3_k127_1734378_3	428125.CLOLEP_02088	4.176e-113	374.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
EH3_k127_1734378_1	1125863.JAFN01000001_gene1869	4.233e-174	576.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
EH3_k127_1734378_2	710111.FraQA3DRAFT_6333	2.434e-115	379.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4ERRI@85013|Frankiales	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
EH3_k127_1734378_0	1907.SGLAU_02855	4.344e-232	732.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria	201174|Actinobacteria	E	PHP domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
EH3_k127_1734378_4	67332.FM21_09230	5.001e-26	117.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the DNA glycosylase MPG family	alkA	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
EH3_k127_1735184_2	2074.JNYD01000023_gene1340	2.436e-51	196.0	COG2120@1|root,COG2120@2|Bacteria,2IDT2@201174|Actinobacteria,4EBAF@85010|Pseudonocardiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K22135	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
EH3_k127_1735184_4	525909.Afer_1639	5.355e-28	124.0	COG3340@1|root,COG3340@2|Bacteria,2HH0B@201174|Actinobacteria,4CP0Q@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
EH3_k127_1735184_1	1123371.ATXH01000032_gene460	4.208e-75	258.0	COG0177@1|root,COG0177@2|Bacteria,2GH3R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
EH3_k127_1735184_3	1382356.JQMP01000001_gene895	1.583e-35	154.0	COG0584@1|root,COG0584@2|Bacteria,2G6YD@200795|Chloroflexi,27Z0U@189775|Thermomicrobia	189775|Thermomicrobia	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
EH3_k127_1735184_0	391625.PPSIR1_35022	4.601e-89	301.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,42SMW@68525|delta/epsilon subdivisions,2WPP1@28221|Deltaproteobacteria,2YUYP@29|Myxococcales	28221|Deltaproteobacteria	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
EH3_k127_175883_8	68219.JNXI01000032_gene7052	2.05e-10	67.0	COG3794@1|root,COG3794@2|Bacteria,2GS7W@201174|Actinobacteria	201174|Actinobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
EH3_k127_175883_3	28444.JODQ01000001_gene2572	2.083e-83	293.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4EGJM@85012|Streptosporangiales	201174|Actinobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
EH3_k127_175883_6	290397.Adeh_0620	5.37e-32	134.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,42UZH@68525|delta/epsilon subdivisions,2WR2R@28221|Deltaproteobacteria,2YVFS@29|Myxococcales	28221|Deltaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
EH3_k127_175883_1	1254432.SCE1572_36775	3.073e-120	406.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WJV1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
EH3_k127_175883_7	1122611.KB903948_gene6748	7.712e-23	106.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4EIYX@85012|Streptosporangiales	201174|Actinobacteria	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
EH3_k127_175883_0	471852.Tcur_3247	1.973e-128	421.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4EFKP@85012|Streptosporangiales	201174|Actinobacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
EH3_k127_175883_5	273068.TTE0963	1.881e-38	146.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,42GH7@68295|Thermoanaerobacterales	186801|Clostridia	FG	PFAM Histidine triad (HIT) protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
EH3_k127_175883_2	1283283.ATXA01000004_gene4270	1.028e-99	343.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4ERI5@85013|Frankiales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
EH3_k127_175883_4	1236902.ANAS01000009_gene2624	2.856e-61	225.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4EHDY@85012|Streptosporangiales	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
EH3_k127_177329_1	166318.Syn8016DRAFT_2888	4.479e-24	104.0	COG0329@1|root,COG0329@2|Bacteria,1G0HP@1117|Cyanobacteria,1GYAH@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
EH3_k127_177329_0	1051632.TPY_1683	2.027e-169	550.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,3WCCG@538999|Clostridiales incertae sedis	186801|Clostridia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
EH3_k127_177329_2	337191.KTR9_2110	1.559e-08	65.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4GD0I@85026|Gordoniaceae	201174|Actinobacteria	D	Ftsk_gamma	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
EH3_k127_1777911_1	1229485.AMYV01000011_gene202	1.041e-30	139.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	(ABC) transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
EH3_k127_1777911_2	1313172.YM304_31920	6.93e-23	114.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
EH3_k127_1777911_0	525904.Tter_1099	2.516e-46	186.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1788433_1	390989.JOEG01000012_gene3414	2.161e-41	171.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4DA3T@85008|Micromonosporales	201174|Actinobacteria	L	Putative exonuclease SbcCD, C subunit	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
EH3_k127_1788433_5	543632.JOJL01000020_gene526	0.0001545	55.0	COG5002@1|root,COG5002@2|Bacteria,2GMH4@201174|Actinobacteria,4DAGR@85008|Micromonosporales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	baeS	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_1788433_4	1172188.KB911825_gene3704	1.412e-06	62.0	COG4585@1|root,COG4585@2|Bacteria,2IAG1@201174|Actinobacteria,4FEJ3@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9,Response_reg
EH3_k127_1788433_2	1463879.JOHP01000004_gene6498	4.638e-39	153.0	COG1607@1|root,COG1607@2|Bacteria,2GK6X@201174|Actinobacteria	201174|Actinobacteria	I	Acyl-CoA hydrolase	-	-	3.1.2.23	ko:K01075,ko:K10806	ko00130,ko00362,ko01040,ko01100,ko01110,ko01120,map00130,map00362,map01040,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
EH3_k127_1788433_0	105559.Nwat_1319	2.096e-172	555.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
EH3_k127_1851377_0	266117.Rxyl_2466	8.448e-195	619.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CPHH@84995|Rubrobacteria	84995|Rubrobacteria	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
EH3_k127_1870451_2	1043205.AFYF01000017_gene1043	1.142e-31	142.0	COG1012@1|root,COG1012@2|Bacteria,2GMNB@201174|Actinobacteria,4FJ2A@85021|Intrasporangiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
EH3_k127_1870451_4	1122223.KB890688_gene1875	1.264e-11	77.0	COG0179@1|root,COG0179@2|Bacteria	2|Bacteria	Q	Fumarylacetoacetate (FAA) hydrolase	mhpD	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
EH3_k127_1870451_0	471852.Tcur_4459	1.756e-87	298.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,4EHTN@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
EH3_k127_1870451_1	1382306.JNIM01000001_gene4028	3.524e-70	251.0	COG0506@1|root,COG0506@2|Bacteria,2G6B6@200795|Chloroflexi	200795|Chloroflexi	C	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
EH3_k127_1870451_3	1121440.AUMA01000007_gene1337	5.181e-19	95.0	COG1309@1|root,COG1309@2|Bacteria,1MYVR@1224|Proteobacteria,42SV2@68525|delta/epsilon subdivisions,2WPSA@28221|Deltaproteobacteria,2MBKN@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
EH3_k127_1878148_2	935839.JAGJ01000013_gene2895	9.095e-14	77.0	COG1228@1|root,COG1228@2|Bacteria,2IISK@201174|Actinobacteria,4F5R2@85017|Promicromonosporaceae	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH3_k127_1878148_0	222534.KB893783_gene5230	1.529e-287	896.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4ERJA@85013|Frankiales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
EH3_k127_1878148_1	414996.IL38_11680	9.215e-67	237.0	COG1878@1|root,COG1878@2|Bacteria,2GNFV@201174|Actinobacteria	201174|Actinobacteria	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
EH3_k127_1919812_2	67332.FM21_28100	1.705e-37	153.0	COG1877@1|root,COG1877@2|Bacteria,2GMKW@201174|Actinobacteria	201174|Actinobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
EH3_k127_1919812_0	1246445.ANAY01000002_gene3423	4.8e-124	430.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4EGDH@85012|Streptosporangiales	201174|Actinobacteria	G	Glycosyltransferase family 20	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
EH3_k127_1919812_1	1089553.Tph_c26450	2.05e-120	399.0	COG0438@1|root,COG0438@2|Bacteria,1TS4X@1239|Firmicutes,24BYU@186801|Clostridia,42F0Q@68295|Thermoanaerobacterales	186801|Clostridia	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
EH3_k127_1919812_3	1121380.JNIW01000002_gene2359	6.017e-24	107.0	COG1959@1|root,COG1959@2|Bacteria,1WIBU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Transcriptional regulator, BadM Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
EH3_k127_1924431_3	28444.JODQ01000017_gene6543	1.843e-33	141.0	COG2380@1|root,COG2380@2|Bacteria,2I8F9@201174|Actinobacteria,4EI5H@85012|Streptosporangiales	201174|Actinobacteria	S	COGs COG2380 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1924431_0	1122182.KB903837_gene3715	1.171e-182	590.0	COG0433@1|root,COG0433@2|Bacteria,2I0H5@201174|Actinobacteria,4D9TP@85008|Micromonosporales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
EH3_k127_1924431_1	926554.KI912645_gene1597	3.6e-67	251.0	COG0420@1|root,COG0420@2|Bacteria,1WJ9N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
EH3_k127_1924431_2	649638.Trad_1105	4.357e-53	200.0	COG0419@1|root,COG0419@2|Bacteria,1WJ38@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	ATPase involved in DNA repair	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
EH3_k127_2133010_2	42256.RradSPS_3092	3.165e-63	227.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH3_k127_2133010_3	219305.MCAG_00296	9.655e-60	227.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,4DAW3@85008|Micromonosporales	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
EH3_k127_2133010_5	266117.Rxyl_3106	1.091e-50	198.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4CPVG@84995|Rubrobacteria	84995|Rubrobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
EH3_k127_2133010_1	479434.Sthe_0968	8.148e-95	320.0	COG1088@1|root,COG1088@2|Bacteria,2G5KR@200795|Chloroflexi,27XGB@189775|Thermomicrobia	189775|Thermomicrobia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
EH3_k127_2133010_4	479434.Sthe_0904	1.099e-57	217.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
EH3_k127_2133010_0	566461.SSFG_04775	6.557e-120	397.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
EH3_k127_2133010_6	477641.MODMU_5056	8.354e-05	49.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4ESMP@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM cell envelope-related function transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
EH3_k127_2191435_1	1179773.BN6_02650	7.473e-149	492.0	COG1506@1|root,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria,4DZST@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Prolyl oligopeptidase family	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
EH3_k127_2191435_2	649638.Trad_2634	1.525e-75	264.0	COG0702@1|root,COG0702@2|Bacteria,1WJH3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10,NmrA
EH3_k127_2191435_4	1896.JOAU01000004_gene95	4.305e-24	115.0	2EB9B@1|root,3359U@2|Bacteria,2GSA6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
EH3_k127_2191435_3	1127673.GLIP_0399	1.03e-26	113.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,4679F@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the P(II) protein family	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046890,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
EH3_k127_2191435_0	880073.Calab_2352	1e-233	729.0	COG0334@1|root,COG0334@2|Bacteria,2NNTY@2323|unclassified Bacteria	2|Bacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
EH3_k127_221968_5	253839.SSNG_04366	2.046e-18	87.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
EH3_k127_221968_1	446468.Ndas_0358	6.915e-94	318.0	COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4EHVD@85012|Streptosporangiales	201174|Actinobacteria	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
EH3_k127_221968_2	1121946.AUAX01000006_gene3555	3.506e-51	199.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4DBWZ@85008|Micromonosporales	201174|Actinobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
EH3_k127_221968_6	101510.RHA1_ro11324	4.345e-05	54.0	2FIJ7@1|root,34AB9@2|Bacteria,2GUPT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_221968_0	867903.ThesuDRAFT_01319	4.863e-95	322.0	COG1063@1|root,COG1063@2|Bacteria,1TPIW@1239|Firmicutes,24AY7@186801|Clostridia,3WDFJ@538999|Clostridiales incertae sedis	186801|Clostridia	C	Alcohol dehydrogenase GroES-like domain	adhB	-	1.1.1.1,1.1.1.284,1.2.1.46	ko:K00121,ko:K00148	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00604,R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00188,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
EH3_k127_221968_3	1463903.JOIZ01000003_gene1743	1.386e-35	140.0	COG3255@1|root,COG3255@2|Bacteria	2|Bacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH3_k127_221968_4	264732.Moth_1913	2.375e-20	99.0	COG1266@1|root,COG1266@2|Bacteria,1UUMR@1239|Firmicutes,25CF0@186801|Clostridia,42GZJ@68295|Thermoanaerobacterales	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH3_k127_2228667_1	469371.Tbis_3438	7.086e-68	235.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4DZQQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	cytochrome P450	cyp20	-	1.14.14.1	ko:K00493	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko01000	-	-	-	p450
EH3_k127_2228667_4	469383.Cwoe_0932	1.161e-18	93.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	mazF5	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
EH3_k127_2228667_0	926560.KE387023_gene3024	4.025e-95	323.0	COG0604@1|root,COG0604@2|Bacteria,1WM8H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
EH3_k127_2228667_2	1146883.BLASA_4591	2.133e-21	104.0	COG0671@1|root,COG1718@1|root,COG0671@2|Bacteria,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	kdkA	-	2.7.1.166,3.6.1.27	ko:K11211,ko:K19302	ko00540,ko00550,map00540,map00550	-	R05627,R09767	RC00002,RC00078	ko00000,ko00001,ko01000,ko01011	-	-	-	Kdo,PAP2
EH3_k127_2274775_3	196162.Noca_0968	7.927e-30	119.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH3_k127_2274775_0	196162.Noca_0969	6.486e-214	690.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH3_k127_2274775_2	1123072.AUDH01000007_gene1145	1.83e-42	162.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,2JTBZ@204441|Rhodospirillales	204441|Rhodospirillales	T	Phosphohistidine phosphatase SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
EH3_k127_2274775_1	1304874.JAFY01000005_gene1251	9.802e-103	345.0	COG0018@1|root,COG0018@2|Bacteria,3TA5K@508458|Synergistetes	508458|Synergistetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
EH3_k127_2359178_6	1122611.KB903941_gene2102	2.126e-18	88.0	COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,4EI83@85012|Streptosporangiales	201174|Actinobacteria	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
EH3_k127_2359178_3	96561.Dole_1971	3.328e-67	242.0	COG1216@1|root,COG1216@2|Bacteria,1QW1K@1224|Proteobacteria,43BRI@68525|delta/epsilon subdivisions,2WN0V@28221|Deltaproteobacteria,2MM2M@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
EH3_k127_2359178_0	479434.Sthe_2765	1.264e-181	575.0	COG0451@1|root,COG0451@2|Bacteria,2G5M4@200795|Chloroflexi	200795|Chloroflexi	GM	PFAM NAD-dependent epimerase dehydratase	-	-	3.13.1.1	ko:K06118	ko00520,ko00561,map00520,map00561	-	R05775	RC01469	ko00000,ko00001,ko01000	-	-	-	Epimerase
EH3_k127_2359178_1	357808.RoseRS_3113	1.892e-132	450.0	COG0520@1|root,COG0520@2|Bacteria,2G5W7@200795|Chloroflexi,375CE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
EH3_k127_2359178_2	1193181.BN10_690004	5.396e-78	271.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FFNS@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH3_k127_2359178_5	446466.Cfla_3577	2.15e-35	143.0	COG2306@1|root,COG2306@2|Bacteria,2GJP9@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF402
EH3_k127_2359178_7	1122947.FR7_3801	0.0003847	46.0	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,4H4QE@909932|Negativicutes	909932|Negativicutes	E	Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
EH3_k127_2376488_4	298653.Franean1_5272	1.027e-61	215.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4ERKD@85013|Frankiales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
EH3_k127_2376488_0	1121877.JQKF01000001_gene1378	8.554e-86	289.0	COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4CMUY@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
EH3_k127_2376488_1	471852.Tcur_1528	3.572e-84	295.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4EI7Y@85012|Streptosporangiales	201174|Actinobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
EH3_k127_2376488_5	1110697.NCAST_05_00190	3.712e-58	226.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4FUZ6@85025|Nocardiaceae	201174|Actinobacteria	G	Inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008934,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016053,GO:0016137,GO:0016138,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
EH3_k127_2376488_2	570967.JMLV01000001_gene2520	3.112e-72	255.0	COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TT7X@28211|Alphaproteobacteria,2JRGC@204441|Rhodospirillales	204441|Rhodospirillales	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
EH3_k127_2376488_3	1047013.AQSP01000067_gene2204	1.153e-64	235.0	COG0436@1|root,COG0436@2|Bacteria,2NR19@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_2384334_4	266940.Krad_2943	1.621e-17	84.0	COG0237@1|root,COG2320@1|root,COG0237@2|Bacteria,COG2320@2|Bacteria,2GN96@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
EH3_k127_2384334_1	446462.Amir_5522	8.147e-164	529.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4DYWG@85010|Pseudonocardiales	201174|Actinobacteria	J	Ribosomal protein S1	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
EH3_k127_2384334_0	1394178.AWOO02000083_gene4527	8.58e-228	735.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4EH6R@85012|Streptosporangiales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
EH3_k127_2384334_2	1463934.JOCF01000044_gene204	1.785e-65	234.0	COG0672@1|root,COG0672@2|Bacteria,2GJ22@201174|Actinobacteria	201174|Actinobacteria	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
EH3_k127_2384334_3	1122609.AUGT01000002_gene3998	3.358e-53	188.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4DNUK@85009|Propionibacteriales	201174|Actinobacteria	E	Polar amino acid transport system	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
EH3_k127_2391812_5	931627.MycrhDRAFT_3645	2.547e-20	103.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae	201174|Actinobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
EH3_k127_2391812_0	1304874.JAFY01000002_gene574	8.614e-95	331.0	COG5598@1|root,COG5598@2|Bacteria,3TC8U@508458|Synergistetes	508458|Synergistetes	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
EH3_k127_2391812_2	1120949.KB903358_gene5099	3.658e-72	255.0	COG1387@1|root,COG1387@2|Bacteria,2HYSU@201174|Actinobacteria,4DB4Z@85008|Micromonosporales	201174|Actinobacteria	E	PHP domain	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
EH3_k127_2391812_7	85643.Tmz1t_3451	5.226e-10	60.0	COG0537@1|root,COG0537@2|Bacteria,1N422@1224|Proteobacteria,2VT5W@28216|Betaproteobacteria,2KWFC@206389|Rhodocyclales	206389|Rhodocyclales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
EH3_k127_2391812_10	237368.SCABRO_03829	7.406e-07	56.0	COG1226@1|root,32Y28@2|Bacteria,2J0V4@203682|Planctomycetes	203682|Planctomycetes	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
EH3_k127_2391812_8	1120949.KB903328_gene8833	7.365e-08	63.0	2CCJS@1|root,32RVX@2|Bacteria,2IR2M@201174|Actinobacteria,4DK4Z@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2391812_6	671143.DAMO_1478	1.017e-18	93.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0040008,GO:0045926,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0065007,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	RHH_1
EH3_k127_2391812_3	690850.Desaf_1754	1.133e-35	139.0	COG2337@1|root,COG2337@2|Bacteria,1MYU1@1224|Proteobacteria,42UNN@68525|delta/epsilon subdivisions,2WQA2@28221|Deltaproteobacteria,2MFFM@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
EH3_k127_2391812_4	1380390.JIAT01000010_gene4968	1.65e-35	146.0	COG3631@1|root,COG3631@2|Bacteria,2GRE5@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
EH3_k127_2391812_1	1246995.AFR_26515	4.25e-90	305.0	COG0421@1|root,COG0421@2|Bacteria,2I2TN@201174|Actinobacteria,4DBUZ@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2391812_9	1449346.JQMO01000002_gene592	5.78e-07	54.0	COG1309@1|root,COG1309@2|Bacteria,2HAUK@201174|Actinobacteria,2M23J@2063|Kitasatospora	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
EH3_k127_2409570_1	768706.Desor_3109	4.683e-73	267.0	COG5557@1|root,COG5557@2|Bacteria,1V4C0@1239|Firmicutes,24NSE@186801|Clostridia,264M3@186807|Peptococcaceae	186801|Clostridia	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
EH3_k127_2409570_2	1227457.C451_04261	1.72e-72	253.0	COG0437@1|root,arCOG01500@2157|Archaea,2XU83@28890|Euryarchaeota,23TXG@183963|Halobacteria	183963|Halobacteria	C	COG0437 Fe-S-cluster-containing hydrogenase components 1	hmoA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4,Fer4_11
EH3_k127_2409570_0	1487923.DP73_13280	3.006e-215	693.0	COG0243@1|root,COG0243@2|Bacteria,1UJ0U@1239|Firmicutes,24DJH@186801|Clostridia,263DS@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
EH3_k127_2452018_5	644966.Tmar_1526	1.446e-87	302.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,3WDEV@538999|Clostridiales incertae sedis	186801|Clostridia	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
EH3_k127_2452018_1	2002.JOEQ01000015_gene5055	1.102e-191	611.0	COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4EGAA@85012|Streptosporangiales	201174|Actinobacteria	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
EH3_k127_2452018_4	512565.AMIS_49470	1.496e-129	425.0	COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria,4DATV@85008|Micromonosporales	201174|Actinobacteria	C	cytochrome d ubiquinol oxidase, subunit	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
EH3_k127_2452018_6	649747.HMPREF0083_04954	9.537e-78	272.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26QK6@186822|Paenibacillaceae	91061|Bacilli	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
EH3_k127_2452018_12	357808.RoseRS_0825	4.831e-29	130.0	COG2068@1|root,COG2068@2|Bacteria,2G6W9@200795|Chloroflexi,377EI@32061|Chloroflexia	32061|Chloroflexia	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
EH3_k127_2452018_14	266940.Krad_0131	5.333e-12	74.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
EH3_k127_2452018_7	479434.Sthe_0254	3.183e-77	267.0	COG0388@1|root,COG0388@2|Bacteria,2G6KM@200795|Chloroflexi,27XTA@189775|Thermomicrobia	189775|Thermomicrobia	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
EH3_k127_2452018_2	1121918.ARWE01000001_gene385	4.199e-159	512.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WTRK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
EH3_k127_2452018_0	1122223.KB890688_gene1647	5.135e-224	704.0	COG1012@1|root,COG1012@2|Bacteria,1WJFH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
EH3_k127_2452018_11	1122939.ATUD01000001_gene471	2.86e-34	149.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria,4CTCD@84995|Rubrobacteria	84995|Rubrobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
EH3_k127_2452018_8	859657.RPSI07_mp0564	1.547e-74	259.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2VQC5@28216|Betaproteobacteria,1K1V9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Pfam Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
EH3_k127_2452018_13	1380393.JHVP01000004_gene401	9.083e-22	101.0	COG5416@1|root,COG5416@2|Bacteria,2HD5K@201174|Actinobacteria	201174|Actinobacteria	S	Lipopolysaccharide assembly protein A domain	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
EH3_k127_2452018_10	1179773.BN6_02410	5.799e-41	176.0	COG0457@1|root,COG3629@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4DZ35@85010|Pseudonocardiales	201174|Actinobacteria	K	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8,Trans_reg_C
EH3_k127_2452018_3	1144312.PMI09_04985	1.142e-140	494.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,Guanylate_cyc,SAM_1,SAM_2,TPR_12,TPR_4
EH3_k127_2452018_9	561175.KB894098_gene5236	1.854e-53	201.0	COG0665@1|root,COG0665@2|Bacteria,2HFWH@201174|Actinobacteria,4EPWJ@85012|Streptosporangiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_2475214_0	656519.Halsa_2055	1.787e-84	291.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH3_k127_2475214_2	246200.SPO2833	3.544e-76	272.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2TUCW@28211|Alphaproteobacteria,4NBJD@97050|Ruegeria	28211|Alphaproteobacteria	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH3_k127_2475214_1	765911.Thivi_0898	1.439e-81	286.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales	135613|Chromatiales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH3_k127_2479565_3	378806.STAUR_2094	3.639e-47	175.0	COG1080@1|root,COG1925@1|root,COG3412@1|root,COG1080@2|Bacteria,COG1925@2|Bacteria,COG3412@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WJ6F@28221|Deltaproteobacteria,2YU1Z@29|Myxococcales	28221|Deltaproteobacteria	G	PTS HPr component phosphorylation site	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr
EH3_k127_2479565_5	589924.Ferp_1246	2e-09	64.0	COG2142@1|root,arCOG04162@2157|Archaea,2XZQ6@28890|Euryarchaeota,246EE@183980|Archaeoglobi	183980|Archaeoglobi	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
EH3_k127_2479565_4	926569.ANT_27580	2.333e-16	91.0	COG2009@1|root,COG2009@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	-	ko:K00241,ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
EH3_k127_2479565_2	882.DVU_2674	5.909e-51	191.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
EH3_k127_2479565_1	1499967.BAYZ01000026_gene1648	9.482e-129	422.0	COG0578@1|root,COG0578@2|Bacteria	2|Bacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C,Fer2_BFD
EH3_k127_2479565_0	357808.RoseRS_1768	3.168e-269	835.0	COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi,3751K@32061|Chloroflexia	32061|Chloroflexia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
EH3_k127_254120_5	1123366.TH3_03250	1.061e-50	189.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JSXK@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,FecR,HemolysinCabind,Laminin_G_3
EH3_k127_254120_3	1157490.EL26_00610	1.435e-63	226.0	COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
EH3_k127_254120_2	204669.Acid345_2367	1.281e-82	287.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria,2JIUS@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
EH3_k127_254120_7	1121920.AUAU01000008_gene1566	5.523e-34	143.0	COG0697@1|root,COG0697@2|Bacteria,3Y5RD@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_254120_0	1122622.ATWJ01000014_gene448	1.372e-178	568.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4FG41@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
EH3_k127_254120_1	471856.Jden_1228	1.764e-106	359.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.7.1.11,2.7.1.90	ko:K02351,ko:K07245,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000,ko02000	9.B.62.1	-	-	PFK
EH3_k127_254120_9	1158292.JPOE01000005_gene1188	3.7e-12	80.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,1KKH7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
EH3_k127_254120_4	285535.JOEY01000003_gene10286	1.639e-51	191.0	COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria	201174|Actinobacteria	S	Esterase	yvaK	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
EH3_k127_254120_6	324602.Caur_3918	4.599e-44	174.0	COG1528@1|root,COG1528@2|Bacteria,2G8JG@200795|Chloroflexi,37728@32061|Chloroflexia	32061|Chloroflexia	C	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
EH3_k127_254120_8	1210045.ALNP01000009_gene4821	2.15e-15	83.0	COG3568@1|root,COG3568@2|Bacteria,2GMRU@201174|Actinobacteria	201174|Actinobacteria	S	endonuclease exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
EH3_k127_2548535_7	446462.Amir_5824	8.123e-32	126.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4E5U5@85010|Pseudonocardiales	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
EH3_k127_2548535_0	469371.Tbis_1068	7.994e-258	816.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4DYX9@85010|Pseudonocardiales	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
EH3_k127_2548535_1	1394178.AWOO02000010_gene4176	1.362e-134	441.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4EHPV@85012|Streptosporangiales	201174|Actinobacteria	S	Insulinase (Peptidase family M16)	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
EH3_k127_2548535_3	263358.VAB18032_12020	8.235e-75	261.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4D8IW@85008|Micromonosporales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
EH3_k127_2548535_6	1385521.N803_15620	9.656e-54	199.0	COG2120@1|root,COG2120@2|Bacteria,2IBQH@201174|Actinobacteria,4FI8N@85021|Intrasporangiaceae	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
EH3_k127_2548535_2	1254432.SCE1572_02475	2.621e-87	302.0	COG4552@1|root,COG4552@2|Bacteria,1NBTH@1224|Proteobacteria,42W5G@68525|delta/epsilon subdivisions,2WXK2@28221|Deltaproteobacteria,2YW0Z@29|Myxococcales	28221|Deltaproteobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
EH3_k127_2548535_9	66429.JOFL01000016_gene245	1.79e-06	59.0	COG1280@1|root,COG1280@2|Bacteria,2INXA@201174|Actinobacteria	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
EH3_k127_2548535_5	1304865.JAGF01000001_gene3122	6.577e-63	220.0	COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria	201174|Actinobacteria	S	adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
EH3_k127_2548535_4	1218173.BALCAV_0200010	6.672e-69	242.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,4H9K9@91061|Bacilli,1ZBNR@1386|Bacillus	91061|Bacilli	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
EH3_k127_2615658_0	58123.JOFJ01000002_gene2626	1.771e-101	341.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4EHRB@85012|Streptosporangiales	201174|Actinobacteria	C	FAD binding domain	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
EH3_k127_2615658_3	656024.FsymDg_4007	3.666e-37	145.0	COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4ESXK@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
EH3_k127_2615658_1	1380347.JNII01000010_gene2319	5.497e-73	253.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4ERM4@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
EH3_k127_2615658_2	103733.JNYO01000004_gene7889	9.122e-46	178.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4DY4U@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
EH3_k127_2615658_4	278963.ATWD01000002_gene384	7.473e-09	65.0	COG0649@1|root,COG0649@2|Bacteria,3Y3N1@57723|Acidobacteria,2JIDU@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
EH3_k127_2627109_2	1068980.ARVW01000001_gene8101	2.431e-157	502.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DXRB@85010|Pseudonocardiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
EH3_k127_2627109_0	543632.JOJL01000008_gene5597	1.694e-216	695.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4DB3M@85008|Micromonosporales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
EH3_k127_2627109_7	67352.JODS01000001_gene476	6.286e-71	258.0	COG1572@1|root,COG1572@2|Bacteria,2GKNI@201174|Actinobacteria	201174|Actinobacteria	Q	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF5122,HemolysinCabind
EH3_k127_2627109_6	543632.JOJL01000035_gene5071	1.083e-83	289.0	arCOG06481@1|root,2ZB4E@2|Bacteria,2I95D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2627109_13	1227487.C474_20179	2.027e-07	63.0	COG4250@1|root,arCOG02909@2157|Archaea,2XW9P@28890|Euryarchaeota,23TM7@183963|Halobacteria	183963|Halobacteria	T	sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	DICT
EH3_k127_2627109_11	1246995.AFR_27135	7.049e-21	104.0	COG1670@1|root,COG1670@2|Bacteria,2IIWF@201174|Actinobacteria,4DJ5S@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128,2.3.1.82	ko:K00663,ko:K03790	-	-	-	-	ko00000,ko01000,ko01504,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_3
EH3_k127_2627109_9	323848.Nmul_A2249	2.641e-24	110.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
EH3_k127_2627109_12	1449069.JMLO01000005_gene1335	2.002e-12	70.0	COG2261@1|root,COG2261@2|Bacteria,2HI6H@201174|Actinobacteria,4G30J@85025|Nocardiaceae	201174|Actinobacteria	S	transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
EH3_k127_2627109_1	1348663.KCH_72370	1.493e-178	571.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria,2M0ZR@2063|Kitasatospora	201174|Actinobacteria	F	Amidohydrolase family	hyuA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
EH3_k127_2627109_4	1051632.TPY_1317	1.304e-116	382.0	COG0388@1|root,COG0388@2|Bacteria,1TRMU@1239|Firmicutes,25B19@186801|Clostridia	186801|Clostridia	S	N-carbamoylputrescine amidase	aguB	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
EH3_k127_2627109_3	485913.Krac_11396	4.097e-122	403.0	COG2141@1|root,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH3_k127_2627109_8	880073.Calab_3048	2.397e-49	183.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
EH3_k127_2627109_5	452637.Oter_3676	1.342e-92	314.0	COG2048@1|root,COG2048@2|Bacteria	2|Bacteria	C	Heterodisulfide reductase, subunit B	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
EH3_k127_2627109_10	1123372.AUIT01000008_gene532	2.309e-21	98.0	COG1148@1|root,COG1148@2|Bacteria,2GHHV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored,Fer4,Pyr_redox_2
EH3_k127_2717148_0	525904.Tter_1698	6.687e-224	714.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
EH3_k127_2717148_1	471852.Tcur_0550	3.275e-96	328.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
EH3_k127_2717148_2	937777.Deipe_2820	8.162e-27	114.0	COG2151@1|root,COG2151@2|Bacteria,1WK4T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG2151 metal-sulfur cluster biosynthetic protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
EH3_k127_2778138_1	324602.Caur_0243	4.418e-109	366.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi,3770N@32061|Chloroflexia	32061|Chloroflexia	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
EH3_k127_2778138_2	1238182.C882_0684	5.337e-103	353.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,2TTBH@28211|Alphaproteobacteria,2JRMS@204441|Rhodospirillales	204441|Rhodospirillales	E	L-seryl-tRNA selenium transferase	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
EH3_k127_2778138_0	1121946.AUAX01000003_gene1734	3.356e-132	437.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4DACF@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
EH3_k127_2778138_3	208439.AJAP_16180	4.197e-10	72.0	COG4409@1|root,COG4409@2|Bacteria,2ICIA@201174|Actinobacteria,4EBQC@85010|Pseudonocardiales	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
EH3_k127_2850639_1	867845.KI911784_gene3645	2.603e-141	465.0	COG1744@1|root,COG1744@2|Bacteria,2G6CN@200795|Chloroflexi	200795|Chloroflexi	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
EH3_k127_2850639_0	864702.OsccyDRAFT_1800	5.889e-152	496.0	COG3845@1|root,COG3845@2|Bacteria,1G4UA@1117|Cyanobacteria,1HH79@1150|Oscillatoriales	1117|Cyanobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
EH3_k127_2850639_3	1125863.JAFN01000001_gene149	1.487e-94	329.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42MWE@68525|delta/epsilon subdivisions,2WKIZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
EH3_k127_2850639_4	321332.CYB_1202	4.617e-83	301.0	COG1079@1|root,COG1079@2|Bacteria,1G3PD@1117|Cyanobacteria,1H0T0@1129|Synechococcus	1117|Cyanobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
EH3_k127_2850639_2	1123322.KB904717_gene5085	1.211e-121	407.0	COG0778@1|root,COG1478@1|root,COG0778@2|Bacteria,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
EH3_k127_2850639_5	765420.OSCT_1607	1.582e-11	67.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi,376XW@32061|Chloroflexia	32061|Chloroflexia	S	TIGRFAM LPPG domain	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
EH3_k127_2939507_4	1035308.AQYY01000001_gene3410	2.109e-76	269.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
EH3_k127_2939507_1	1452536.JARE01000050_gene2001	1.461e-251	790.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4FKYU@85023|Microbacteriaceae	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
EH3_k127_2939507_8	28444.JODQ01000001_gene2595	1.115e-16	84.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4EKBP@85012|Streptosporangiales	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
EH3_k127_2939507_7	1352941.M877_29070	3.657e-19	101.0	COG1466@1|root,COG1466@2|Bacteria,2GNMZ@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
EH3_k127_2939507_3	106370.Francci3_1258	2.85e-92	332.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4ES7C@85013|Frankiales	201174|Actinobacteria	S	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
EH3_k127_2939507_6	1298863.AUEP01000005_gene2586	1.137e-35	150.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4DRFZ@85009|Propionibacteriales	201174|Actinobacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
EH3_k127_2939507_5	484770.UFO1_0782	1.551e-36	158.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,4H2EB@909932|Negativicutes	909932|Negativicutes	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
EH3_k127_2939507_2	326427.Cagg_3438	1.745e-209	662.0	COG3033@1|root,COG3033@2|Bacteria,2G7YV@200795|Chloroflexi,376SB@32061|Chloroflexia	32061|Chloroflexia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tpl	-	4.1.99.2	ko:K01668	ko00350,map00350	-	R00728	RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
EH3_k127_2939507_0	351607.Acel_0771	7.471e-290	912.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4ERFA@85013|Frankiales	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
EH3_k127_2946909_0	469371.Tbis_2475	2.076e-155	494.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4DYXZ@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
EH3_k127_2946909_2	663610.JQKO01000012_gene3098	3.464e-13	81.0	COG3187@1|root,COG3187@2|Bacteria,1QVKJ@1224|Proteobacteria,2UI8A@28211|Alphaproteobacteria,3ND0S@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
EH3_k127_2946909_1	1463936.JOJI01000005_gene4126	2.282e-53	206.0	28MY8@1|root,2ZB54@2|Bacteria,2GMYY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2953205_7	765420.OSCT_2229	2.304e-35	146.0	COG2843@1|root,COG2843@2|Bacteria,2GB5U@200795|Chloroflexi,377DF@32061|Chloroflexia	32061|Chloroflexia	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
EH3_k127_2953205_12	926554.KI912625_gene677	7.411e-11	66.0	COG4374@1|root,COG4374@2|Bacteria,1WK8Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
EH3_k127_2953205_6	471853.Bcav_0518	1.234e-46	178.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria	201174|Actinobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
EH3_k127_2953205_9	591157.SSLG_03495	3.241e-30	123.0	COG3824@1|root,COG3824@2|Bacteria,2IKXW@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
EH3_k127_2953205_3	298653.Franean1_5671	8.128e-98	330.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4EUWY@85013|Frankiales	201174|Actinobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
EH3_k127_2953205_8	2074.JNYD01000026_gene642	1.137e-32	137.0	COG3255@1|root,COG3255@2|Bacteria,2GJ5N@201174|Actinobacteria,4E360@85010|Pseudonocardiales	201174|Actinobacteria	I	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,SCP2
EH3_k127_2953205_2	765420.OSCT_2611	1.153e-104	368.0	COG0309@1|root,COG0309@2|Bacteria,2G5MV@200795|Chloroflexi,376G0@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
EH3_k127_2953205_1	234267.Acid_6552	6.714e-160	518.0	COG0409@1|root,COG0409@2|Bacteria,3Y405@57723|Acidobacteria	57723|Acidobacteria	O	Hydrogenase formation hypA family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
EH3_k127_2953205_10	240015.ACP_3060	6.677e-28	115.0	COG0298@1|root,COG0298@2|Bacteria,3Y5NM@57723|Acidobacteria,2JK31@204432|Acidobacteriia	204432|Acidobacteriia	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
EH3_k127_2953205_0	928724.SacglDRAFT_00857	1.207e-221	711.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4DYVA@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
EH3_k127_2953205_11	240015.ACP_3055	2.424e-12	74.0	COG0680@1|root,COG0680@2|Bacteria,3Y9G5@57723|Acidobacteria,2JNUV@204432|Acidobacteriia	204432|Acidobacteriia	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
EH3_k127_2953205_4	429009.Adeg_0292	2.72e-90	317.0	COG5557@1|root,COG5557@2|Bacteria,1TSZC@1239|Firmicutes,24BX8@186801|Clostridia	186801|Clostridia	C	PFAM Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
EH3_k127_2953205_5	696369.KI912183_gene1010	8.444e-75	265.0	COG0437@1|root,COG0437@2|Bacteria,1UAZU@1239|Firmicutes,24DY6@186801|Clostridia,26083@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Fer4_7
EH3_k127_2957758_4	1114856.C496_16152	3.301e-06	55.0	COG2141@1|root,arCOG02410@2157|Archaea,2XVYJ@28890|Euryarchaeota,23U6J@183963|Halobacteria	183963|Halobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH3_k127_2957758_1	710111.FraQA3DRAFT_6431	3.454e-77	284.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4ERT7@85013|Frankiales	201174|Actinobacteria	GK	PFAM ROK family protein	glkA	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
EH3_k127_2957758_3	1125863.JAFN01000001_gene739	8.071e-20	104.0	COG1503@1|root,COG1503@2|Bacteria,1NHEV@1224|Proteobacteria,42XGN@68525|delta/epsilon subdivisions,2WTEW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	translation release factor activity	-	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	-
EH3_k127_2957758_0	42256.RradSPS_1289	7.623e-126	418.0	COG0003@1|root,COG0003@2|Bacteria,2GISZ@201174|Actinobacteria,4CPDY@84995|Rubrobacteria	84995|Rubrobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
EH3_k127_2957758_2	479433.Caci_6066	5.153e-23	105.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria	201174|Actinobacteria	I	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
EH3_k127_2972945_0	1380390.JIAT01000010_gene3567	0.0	1446.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
EH3_k127_2972945_1	35754.JNYJ01000127_gene6382	3.884e-09	57.0	COG3547@1|root,COG3547@2|Bacteria,2GNQB@201174|Actinobacteria,4DEQM@85008|Micromonosporales	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
EH3_k127_2980480_1	1121945.ATXS01000019_gene935	5.024e-51	196.0	COG1748@1|root,arCOG00243@2157|Archaea,2Y08S@28890|Euryarchaeota	28890|Euryarchaeota	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
EH3_k127_2980480_0	1394178.AWOO02000040_gene8571	7.294e-158	516.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4EHQQ@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.9	ko:K00128,ko:K00131	ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00135,M00308,M00633	R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
EH3_k127_2980480_2	298653.Franean1_0951	2.058e-33	129.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4ERRA@85013|Frankiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	prr1	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
EH3_k127_3029839_8	309801.trd_0262	5.004e-23	100.0	COG0247@1|root,COG0247@2|Bacteria,2G5V8@200795|Chloroflexi,27XTC@189775|Thermomicrobia	189775|Thermomicrobia	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
EH3_k127_3029839_9	710686.Mycsm_03429	4.096e-22	100.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
EH3_k127_3029839_4	1380394.JADL01000002_gene1727	6.677e-85	299.0	COG0491@1|root,COG0491@2|Bacteria,1N6PM@1224|Proteobacteria,2TRZ4@28211|Alphaproteobacteria,2JVS0@204441|Rhodospirillales	204441|Rhodospirillales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH3_k127_3029839_10	399739.Pmen_3707	6.779e-22	110.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1YGJQ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
EH3_k127_3029839_7	379066.GAU_2937	1.736e-39	156.0	COG1999@1|root,COG2847@1|root,COG1999@2|Bacteria,COG2847@2|Bacteria	2|Bacteria	P	Copper chaperone PCu(A)C	hyaE	GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277	-	ko:K03619,ko:K07152,ko:K09796	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	HyaE,PCuAC,SCO1-SenC
EH3_k127_3029839_3	266117.Rxyl_0115	8.858e-88	304.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CRRF@84995|Rubrobacteria	84995|Rubrobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
EH3_k127_3029839_1	1122138.AQUZ01000012_gene5957	2.781e-93	326.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4DPPD@85009|Propionibacteriales	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
EH3_k127_3029839_0	1032480.MLP_34050	2.352e-203	644.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4DPQT@85009|Propionibacteriales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
EH3_k127_3029839_6	590998.Celf_1395	7.299e-46	177.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4F0J8@85016|Cellulomonadaceae	201174|Actinobacteria	M	PFAM MscS Mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
EH3_k127_3029839_2	266117.Rxyl_0113	4.057e-89	303.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4CSQX@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM molybdopterin dehydrogenase, FAD-binding	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
EH3_k127_3029839_5	266117.Rxyl_0111	1.715e-59	208.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4CT01@84995|Rubrobacteria	84995|Rubrobacteria	C	2Fe-2S -binding	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
EH3_k127_3081052_6	525368.HMPREF0591_5745	2.14e-30	125.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,235CW@1762|Mycobacteriaceae	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
EH3_k127_3081052_4	663278.Ethha_0037	1.333e-52	200.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,3WISD@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
EH3_k127_3081052_2	390989.JOEG01000007_gene596	3.715e-91	319.0	COG2199@1|root,COG3706@2|Bacteria,2IABQ@201174|Actinobacteria,4D9W3@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
EH3_k127_3081052_1	1121468.AUBR01000026_gene2918	2.825e-115	382.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
EH3_k127_3081052_3	1288079.AUKN01000009_gene959	3.121e-56	202.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria	201174|Actinobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
EH3_k127_3081052_0	635013.TherJR_1781	1.79e-164	536.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,260I8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
EH3_k127_3081052_5	562970.Btus_1823	4.906e-48	188.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli,279P7@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08940	DMRL_synthase
EH3_k127_3081052_8	42256.RradSPS_2707	1.361e-22	111.0	COG0662@1|root,COG0662@2|Bacteria,2IPIR@201174|Actinobacteria	201174|Actinobacteria	G	mannose-6-phosphate isomerase	-	-	2.7.7.13,5.3.1.8	ko:K01809,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer
EH3_k127_3081052_7	1157490.EL26_09360	6.911e-27	111.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,27A9T@186823|Alicyclobacillaceae	91061|Bacilli	K	Cold-shock protein	cspC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
EH3_k127_3081052_9	1246445.ANAY01000019_gene1611	1.561e-18	85.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4EGID@85012|Streptosporangiales	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
EH3_k127_311968_2	58123.JOFJ01000001_gene2965	2.356e-83	300.0	COG3568@1|root,COG3568@2|Bacteria,2GP1E@201174|Actinobacteria,4EH07@85012|Streptosporangiales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
EH3_k127_311968_3	479433.Caci_8039	1.873e-09	65.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH3_k127_311968_1	243090.RB6246	8.039e-123	409.0	COG1932@1|root,COG1932@2|Bacteria,2IYR7@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
EH3_k127_311968_0	266117.Rxyl_0056	6.875e-148	475.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4CPC1@84995|Rubrobacteria	84995|Rubrobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
EH3_k127_3145840_2	1120936.KB907208_gene940	8.954e-33	132.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria,4EGJU@85012|Streptosporangiales	201174|Actinobacteria	G	Family 4 glycosyl hydrolase	malH	-	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
EH3_k127_3145840_0	469383.Cwoe_4996	1.778e-106	363.0	COG1940@1|root,COG1940@2|Bacteria,2GJ3W@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR,MarR_2,ROK
EH3_k127_3145840_1	345341.KUTG_04709	2.353e-45	175.0	COG1653@1|root,COG1653@2|Bacteria,2GJYT@201174|Actinobacteria,4DYRH@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
EH3_k127_3149307_4	1134445.AJJM01000023_gene4278	7.147e-52	190.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria	201174|Actinobacteria	S	protein, coenzyme F420 biosynthesis associated	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
EH3_k127_3149307_6	477974.Daud_0086	2.073e-42	171.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,260U4@186807|Peptococcaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
EH3_k127_3149307_3	1157637.KB892094_gene3045	1.724e-68	239.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
EH3_k127_3149307_0	561175.KB894093_gene4254	3.646e-240	758.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4EGHW@85012|Streptosporangiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
EH3_k127_3149307_5	208444.JNYY01000001_gene5310	5.152e-49	187.0	COG1011@1|root,COG1011@2|Bacteria,2IBB1@201174|Actinobacteria,4E7YD@85010|Pseudonocardiales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
EH3_k127_3149307_2	446468.Ndas_4971	6.417e-70	243.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4EIFX@85012|Streptosporangiales	201174|Actinobacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
EH3_k127_3149307_1	1379698.RBG1_1C00001G1625	3.713e-80	277.0	COG0294@1|root,COG0294@2|Bacteria,2NNN7@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
EH3_k127_3149307_7	1121943.KB900011_gene1129	7.611e-29	130.0	COG0596@1|root,COG0596@2|Bacteria,1MVTG@1224|Proteobacteria,1RQ1B@1236|Gammaproteobacteria,1XM9K@135619|Oceanospirillales	135619|Oceanospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
EH3_k127_314969_1	485913.Krac_11262	1.409e-52	191.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
EH3_k127_314969_0	357808.RoseRS_4356	9.277e-212	665.0	COG0166@1|root,COG0166@2|Bacteria,2G5ZM@200795|Chloroflexi,376U7@32061|Chloroflexia	32061|Chloroflexia	F	glucose-6-phosphate isomerase activity	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
EH3_k127_3167751_0	864563.HMPREF9166_2029	3.609e-288	911.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,4H21Q@909932|Negativicutes	909932|Negativicutes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
EH3_k127_3167751_2	1210046.B277_05853	3.241e-90	336.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4FERU@85021|Intrasporangiaceae	201174|Actinobacteria	H	Folylpolyglutamate synthase	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
EH3_k127_3167751_3	1382358.JHVN01000003_gene2850	4.059e-44	165.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,21VKJ@150247|Anoxybacillus	91061|Bacilli	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
EH3_k127_3167751_1	485913.Krac_1224	2.005e-104	359.0	COG1680@1|root,COG1680@2|Bacteria,2G6QM@200795|Chloroflexi	2|Bacteria	V	COGs COG1680 Beta-lactamase class C and other penicillin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
EH3_k127_3170763_3	1344012.ATMI01000001_gene1259	3.942e-52	186.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,4BVHZ@82986|Tatumella	1236|Gammaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
EH3_k127_3170763_1	642227.HA49_06615	2.592e-77	267.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,1SZCN@1236|Gammaproteobacteria,4BVK1@82986|Tatumella	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
EH3_k127_3170763_2	642227.HA49_06620	4.326e-65	235.0	COG0715@1|root,COG0715@2|Bacteria,1QM3B@1224|Proteobacteria,1TJAT@1236|Gammaproteobacteria,4BVGW@82986|Tatumella	1236|Gammaproteobacteria	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
EH3_k127_3170763_4	526225.Gobs_1669	1.424e-27	119.0	COG1487@1|root,COG1487@2|Bacteria,2ISE2@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
EH3_k127_3170763_5	419947.MRA_1572	1.276e-10	64.0	COG5450@1|root,COG5450@2|Bacteria,2GTYZ@201174|Actinobacteria,23BQF@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	GO:0006417,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045727,GO:0045927,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:2000112	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
EH3_k127_3170763_0	263358.VAB18032_28166	1.803e-253	800.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4D961@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
EH3_k127_3237558_5	330084.JNYZ01000005_gene931	1.36e-29	134.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DXRP@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH3_k127_3237558_2	330084.JNYZ01000005_gene930	4.84e-125	419.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
EH3_k127_3237558_3	1320556.AVBP01000030_gene140	1.921e-109	362.0	COG1173@1|root,COG1173@2|Bacteria,1NRWG@1224|Proteobacteria,2UPAF@28211|Alphaproteobacteria,43PKS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH3_k127_3237558_1	1416759.AYMR01000003_gene3372	8.434e-127	413.0	COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4FR2U@85023|Microbacteriaceae	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH3_k127_3237558_0	1416759.AYMR01000003_gene3373	2.265e-159	526.0	COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4FR84@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH3_k127_3237558_4	479432.Sros_2121	5.418e-85	301.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
EH3_k127_3247593_1	396588.Tgr7_1696	2.082e-129	445.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,1RQKR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the GcvT family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
EH3_k127_3247593_8	1089546.AQUI01000002_gene2985	2.155e-17	84.0	COG4311@1|root,COG4311@2|Bacteria,2IQIZ@201174|Actinobacteria	201174|Actinobacteria	E	Sarcosine oxidase	soxD	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
EH3_k127_3247593_0	502025.Hoch_4339	1.597e-147	487.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWPS@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
EH3_k127_3247593_2	1382356.JQMP01000001_gene1084	1.875e-97	330.0	COG1363@1|root,COG1363@2|Bacteria,2G6EE@200795|Chloroflexi,27Y0M@189775|Thermomicrobia	189775|Thermomicrobia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
EH3_k127_3247593_6	1382304.JNIL01000001_gene1787	6.931e-42	174.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,4HHPP@91061|Bacilli,278GY@186823|Alicyclobacillaceae	91061|Bacilli	H	Probable molybdopterin binding domain	moaB	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
EH3_k127_3247593_4	1380386.JIAW01000007_gene3788	8.217e-92	312.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,23B1Y@1762|Mycobacteriaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH3_k127_3247593_3	251221.35211202	1.661e-92	321.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
EH3_k127_3247593_5	219305.MCAG_00296	7.574e-46	187.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,4DAW3@85008|Micromonosporales	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
EH3_k127_3247593_7	219305.MCAG_00296	2.145e-31	126.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,4DAW3@85008|Micromonosporales	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
EH3_k127_328102_2	1449068.JMLQ01000004_gene1346	2.554e-72	257.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FVV0@85025|Nocardiaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
EH3_k127_328102_5	1111069.TCCBUS3UF1_17920	1.425e-09	63.0	COG0662@1|root,COG0662@2|Bacteria,1WK83@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
EH3_k127_328102_0	357808.RoseRS_2771	1.319e-111	382.0	COG1457@1|root,COG1457@2|Bacteria,2G9KC@200795|Chloroflexi,376PN@32061|Chloroflexia	32061|Chloroflexia	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
EH3_k127_328102_4	211114.JOEF01000002_gene4529	6.317e-16	83.0	COG3427@1|root,COG3427@2|Bacteria,2II8Y@201174|Actinobacteria,4E5GT@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
EH3_k127_328102_3	526225.Gobs_3885	7.046e-56	214.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,4ERQE@85013|Frankiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
EH3_k127_328102_1	1051632.TPY_0096	4.095e-79	286.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia	186801|Clostridia	Q	Belongs to the metallo-dependent hydrolases superfamily. HutI family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
EH3_k127_3330017_0	401526.TcarDRAFT_2201	2.451e-161	538.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,4H1Y3@909932|Negativicutes	909932|Negativicutes	J	elongation factor G	fusA_1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
EH3_k127_3330017_1	1122611.KB904007_gene7813	3.341e-53	205.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4EHU2@85012|Streptosporangiales	201174|Actinobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
EH3_k127_3330017_2	1227261.HMPREF0043_01890	1.696e-33	135.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4D3G5@85005|Actinomycetales	201174|Actinobacteria	M	Glycosyltransferase, group 1 family protein	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
EH3_k127_3330068_3	511051.CSE_10910	4.967e-38	155.0	COG2316@1|root,COG2316@2|Bacteria	2|Bacteria	J	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
EH3_k127_3330068_0	1003195.SCAT_4645	8.254e-146	490.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
EH3_k127_3330068_5	1077144.AGFF01000017_gene2725	1.319e-25	109.0	COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	kdpE	-	-	ko:K02483,ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
EH3_k127_3330068_6	105420.BBPO01000034_gene951	5.79e-19	95.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,2NFGU@228398|Streptacidiphilus	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
EH3_k127_3330068_2	106370.Francci3_1323	1.823e-54	198.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4ESF8@85013|Frankiales	201174|Actinobacteria	P	PFAM TrkA-N domain protein	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
EH3_k127_3330068_1	1123023.JIAI01000002_gene5302	4.712e-69	241.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4DY80@85010|Pseudonocardiales	201174|Actinobacteria	P	overlaps another CDS with the same product name	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
EH3_k127_3330068_7	1449347.JQLN01000007_gene2171	4.033e-15	79.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria,2M2XS@2063|Kitasatospora	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3330068_4	469371.Tbis_0223	1.723e-26	111.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4DY9J@85010|Pseudonocardiales	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
EH3_k127_3396257_2	405948.SACE_4008	1.131e-86	291.0	COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria,4DX73@85010|Pseudonocardiales	201174|Actinobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
EH3_k127_3396257_3	1114856.C496_15837	9.939e-77	271.0	COG2057@1|root,arCOG05316@2157|Archaea,2XW2C@28890|Euryarchaeota,23U50@183963|Halobacteria	183963|Halobacteria	I	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
EH3_k127_3396257_4	1157490.EL26_17810	5.01e-76	264.0	COG3340@1|root,COG3340@2|Bacteria,1TRBA@1239|Firmicutes,4HB19@91061|Bacilli	91061|Bacilli	E	Belongs to the peptidase S51 family	ygaJ	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
EH3_k127_3396257_0	1123251.ATWM01000004_gene1974	2.553e-152	493.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4FE6A@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
EH3_k127_3396257_1	471852.Tcur_4452	1.987e-115	384.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4EGFY@85012|Streptosporangiales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
EH3_k127_3396257_5	1122939.ATUD01000011_gene2272	5.314e-16	91.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4CPJ2@84995|Rubrobacteria	84995|Rubrobacteria	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
EH3_k127_3399293_3	365528.KB891263_gene641	2.303e-111	365.0	COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4ERPB@85013|Frankiales	201174|Actinobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	cfa	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
EH3_k127_3399293_10	565033.GACE_1196	7.961e-20	102.0	COG0607@1|root,arCOG02021@2157|Archaea,2Y0YH@28890|Euryarchaeota,2472N@183980|Archaeoglobi	183980|Archaeoglobi	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
EH3_k127_3399293_8	136273.GY22_16945	2.814e-40	160.0	COG0053@1|root,COG0053@2|Bacteria,2HTNG@201174|Actinobacteria,1WBN8@1268|Micrococcaceae	201174|Actinobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
EH3_k127_3399293_0	215803.DB30_7204	3.754e-292	925.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
EH3_k127_3399293_13	1158292.JPOE01000002_gene3598	7.5e-11	73.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1KKA7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
EH3_k127_3399293_1	266117.Rxyl_2783	9.63e-141	470.0	COG2202@1|root,COG5001@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,2GIZF@201174|Actinobacteria,4CRHY@84995|Rubrobacteria	84995|Rubrobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
EH3_k127_3399293_4	1298863.AUEP01000004_gene1875	6.552e-98	332.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4DRSU@85009|Propionibacteriales	201174|Actinobacteria	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
EH3_k127_3399293_7	743718.Isova_0116	8.623e-41	168.0	COG2606@1|root,COG2606@2|Bacteria,2IIIW@201174|Actinobacteria,4F4JZ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
EH3_k127_3399293_11	675635.Psed_2126	1.919e-16	91.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4E0RB@85010|Pseudonocardiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
EH3_k127_3399293_6	69279.BG36_22830	3.921e-52	198.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,43KX1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
EH3_k127_3399293_2	326424.FRAAL1473	7.254e-124	407.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4ESZR@85013|Frankiales	201174|Actinobacteria	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4,3.5.4.40	ko:K01488,ko:K18286	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
EH3_k127_3399293_5	882083.SacmaDRAFT_5669	5.711e-54	194.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DXRB@85010|Pseudonocardiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
EH3_k127_3399293_12	469383.Cwoe_0606	5.914e-13	74.0	COG0599@1|root,COG0599@2|Bacteria,2HUBM@201174|Actinobacteria,4CU1B@84995|Rubrobacteria	84995|Rubrobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3399293_9	1194165.CAJF01000011_gene1031	1.472e-37	149.0	COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2IBM2@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
EH3_k127_3400712_0	351607.Acel_1497	1.674e-65	233.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4ERZM@85013|Frankiales	201174|Actinobacteria	S	Belongs to the CinA family	cinA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
EH3_k127_3400712_2	326427.Cagg_1608	8.672e-15	86.0	COG1426@1|root,COG1426@2|Bacteria,2G773@200795|Chloroflexi,375R5@32061|Chloroflexia	32061|Chloroflexia	S	SMART helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
EH3_k127_3400712_1	688269.Theth_1404	8.941e-60	210.0	COG0221@1|root,COG0221@2|Bacteria,2GCX4@200918|Thermotogae	200918|Thermotogae	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
EH3_k127_34485_0	292459.STH1872	6.407e-130	422.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_34485_5	28444.JODQ01000007_gene5477	2.183e-35	146.0	COG1309@1|root,COG1309@2|Bacteria,2GQRD@201174|Actinobacteria,4EHRF@85012|Streptosporangiales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
EH3_k127_34485_1	1043493.BBLU01000016_gene1503	1.185e-129	442.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994,ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
EH3_k127_34485_2	66875.JODY01000019_gene330	3.964e-91	309.0	COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH3_k127_34485_3	706587.Desti_2480	2.671e-75	259.0	COG4912@1|root,COG4912@2|Bacteria,1RGVM@1224|Proteobacteria,42ZZV@68525|delta/epsilon subdivisions,2WVCM@28221|Deltaproteobacteria,2MRS8@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
EH3_k127_34485_4	197221.22294757	3.757e-43	166.0	COG0726@1|root,COG0726@2|Bacteria,1G54X@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
EH3_k127_3479910_4	710111.FraQA3DRAFT_3420	7.565e-40	157.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4ES6V@85013|Frankiales	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase (Decarboxylating)	gnd2	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1122	6PGD,NAD_binding_2
EH3_k127_3479910_0	1121946.AUAX01000008_gene7362	4.57e-151	488.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria,4D9VG@85008|Micromonosporales	201174|Actinobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
EH3_k127_3479910_5	1313172.YM304_35230	1.096e-32	140.0	COG0791@1|root,COG1196@1|root,COG0791@2|Bacteria,COG1196@2|Bacteria,2GIWB@201174|Actinobacteria,4CNAP@84992|Acidimicrobiia	84992|Acidimicrobiia	M	NlpC/P60 family	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SLT
EH3_k127_3479910_7	562973.HMPREF0059_00949	1.979e-06	49.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4D3ZA@85005|Actinomycetales	201174|Actinobacteria	L	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
EH3_k127_3479910_2	1173021.ALWA01000019_gene468	6.586e-73	258.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
EH3_k127_3479910_3	570268.ANBB01000058_gene4273	1.653e-56	215.0	COG1408@1|root,COG1408@2|Bacteria,2GJHT@201174|Actinobacteria,4EFSI@85012|Streptosporangiales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
EH3_k127_3479910_6	1158318.ATXC01000001_gene854	1.265e-31	130.0	COG1610@1|root,COG1610@2|Bacteria,2G4V2@200783|Aquificae	200783|Aquificae	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
EH3_k127_3479910_1	351607.Acel_2004	7.812e-102	357.0	COG0744@1|root,COG2815@1|root,COG0744@2|Bacteria,COG2815@2|Bacteria,2GK21@201174|Actinobacteria,4ERGQ@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
EH3_k127_3528010_8	96561.Dole_2131	2.083e-46	173.0	COG2220@1|root,COG2220@2|Bacteria,1QB9E@1224|Proteobacteria,42N7W@68525|delta/epsilon subdivisions,2WNMC@28221|Deltaproteobacteria,2MKW3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
EH3_k127_3528010_3	469383.Cwoe_5231	2.117e-119	398.0	COG3892@1|root,COG3892@2|Bacteria,2INPC@201174|Actinobacteria,4CRB8@84995|Rubrobacteria	84995|Rubrobacteria	G	Uncharacterized protein conserved in bacteria (DUF2090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2090
EH3_k127_3528010_13	743720.Psefu_0233	6.417e-08	56.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1YZ2D@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
EH3_k127_3528010_1	570268.ANBB01000063_gene877	3.637e-169	541.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4EFS2@85012|Streptosporangiales	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
EH3_k127_3528010_15	264732.Moth_2043	0.0001228	47.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,42FB3@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
EH3_k127_3528010_11	570268.ANBB01000063_gene876	1.056e-15	81.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4EHR2@85012|Streptosporangiales	201174|Actinobacteria	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	purD	-	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
EH3_k127_3528010_9	264732.Moth_2053	6.518e-35	139.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,42G1V@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
EH3_k127_3528010_2	1121430.JMLG01000005_gene785	3.046e-154	500.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,260RX@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
EH3_k127_3528010_4	1121335.Clst_2374	3.282e-98	348.0	COG0152@1|root,COG0152@2|Bacteria,1VTBC@1239|Firmicutes,24ZTC@186801|Clostridia,3WH16@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
EH3_k127_3528010_12	1282362.AEAC466_11095	2.448e-13	82.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2KHAS@204458|Caulobacterales	204458|Caulobacterales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
EH3_k127_3528010_5	1120941.AUBL01000055_gene1149	4.587e-75	260.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4D3D5@85005|Actinomycetales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
EH3_k127_3528010_0	351607.Acel_2074	3.725e-220	704.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,4ERE3@85013|Frankiales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
EH3_k127_3528010_10	1121439.dsat_2438	8.887e-23	104.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2M7S0@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
EH3_k127_3528010_7	381764.Fnod_0210	1.124e-48	177.0	COG1607@1|root,COG1607@2|Bacteria,2GCWU@200918|Thermotogae	200918|Thermotogae	I	PFAM thioesterase superfamily	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
EH3_k127_3528010_14	28444.JODQ01000003_gene4757	1.856e-06	54.0	COG0454@1|root,COG0456@2|Bacteria,2I3UD@201174|Actinobacteria,4EKTF@85012|Streptosporangiales	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3528010_6	1121926.AXWO01000004_gene1211	1.648e-52	198.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4EYB3@85014|Glycomycetales	201174|Actinobacteria	C	e3 binding domain	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
EH3_k127_3630998_7	1120950.KB892707_gene4878	1.392e-44	175.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4DNDP@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
EH3_k127_3630998_2	1352941.M877_31420	3.003e-123	403.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria	201174|Actinobacteria	S	associated with various cellular activities	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
EH3_k127_3630998_6	1313172.YM304_19370	3.173e-45	175.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4CN5M@84992|Acidimicrobiia	84992|Acidimicrobiia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
EH3_k127_3630998_8	1009370.ALO_20917	7.76e-31	128.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4H4A5@909932|Negativicutes	909932|Negativicutes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
EH3_k127_3630998_5	357808.RoseRS_3778	1.059e-72	256.0	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi,374SY@32061|Chloroflexia	32061|Chloroflexia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
EH3_k127_3630998_0	710111.FraQA3DRAFT_2863	1.751e-143	479.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
EH3_k127_3630998_1	1121346.KB899816_gene3290	2.535e-129	446.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,4H9T1@91061|Bacilli,26R8F@186822|Paenibacillaceae	91061|Bacilli	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
EH3_k127_3630998_4	365528.KB891102_gene4421	5.578e-101	349.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4EREQ@85013|Frankiales	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
EH3_k127_3630998_3	106370.Francci3_1412	3.864e-119	394.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4ERUH@85013|Frankiales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
EH3_k127_3630998_9	1380354.JIAN01000007_gene58	9.285e-10	67.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4F1RP@85016|Cellulomonadaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
EH3_k127_363523_2	1303518.CCALI_01951	1.131e-62	223.0	COG0177@1|root,COG0177@2|Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
EH3_k127_363523_0	298654.FraEuI1c_7162	7.347e-125	413.0	COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,4ERFB@85013|Frankiales	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
EH3_k127_363523_6	1236902.ANAS01000028_gene311	7.03e-33	136.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4EIIV@85012|Streptosporangiales	201174|Actinobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
EH3_k127_363523_7	298653.Franean1_7310	4.53e-27	117.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4ESZ0@85013|Frankiales	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
EH3_k127_363523_4	644283.Micau_6266	9.403e-46	170.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4DCAH@85008|Micromonosporales	201174|Actinobacteria	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
EH3_k127_363523_8	585530.HMPREF0183_0577	1.661e-23	106.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4FAD4@85019|Brevibacteriaceae	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
EH3_k127_363523_9	1242864.D187_000281	0.0002551	49.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,42WQU@68525|delta/epsilon subdivisions,2WTEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Inosine-uridine preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
EH3_k127_363523_1	429009.Adeg_1877	1.846e-94	317.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,42FEE@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
EH3_k127_363523_3	1146883.BLASA_4848	2.34e-57	215.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria,4ES94@85013|Frankiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,GT87,Mannosyl_trans
EH3_k127_363523_5	351607.Acel_2034	2.154e-44	167.0	COG5542@1|root,COG5542@2|Bacteria,2HJW5@201174|Actinobacteria,4ETD2@85013|Frankiales	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
EH3_k127_3641301_0	1394178.AWOO02000025_gene5047	5.442e-168	542.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4ER2C@85012|Streptosporangiales	201174|Actinobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
EH3_k127_3641301_1	266117.Rxyl_0836	8.045e-102	344.0	COG0075@1|root,COG0075@2|Bacteria,2GM5F@201174|Actinobacteria,4CQFE@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase, class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
EH3_k127_3641301_2	446471.Xcel_2806	4.949e-18	98.0	COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria,4F5RS@85017|Promicromonosporaceae	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
EH3_k127_3642101_7	1229780.BN381_50117	5.512e-09	68.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,3UWKE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
EH3_k127_3642101_1	264732.Moth_1692	7.517e-68	244.0	COG3294@1|root,COG3294@2|Bacteria,1UXSS@1239|Firmicutes,24A8Y@186801|Clostridia,42FRF@68295|Thermoanaerobacterales	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
EH3_k127_3642101_6	717231.Flexsi_0076	2.09e-12	73.0	COG1862@1|root,COG1862@2|Bacteria,2GFUW@200930|Deferribacteres	200930|Deferribacteres	U	Preprotein translocase subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
EH3_k127_3642101_0	867903.ThesuDRAFT_01682	9.386e-138	445.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3WCER@538999|Clostridiales incertae sedis	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
EH3_k127_3642101_3	292459.STH1160	9.048e-42	162.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
EH3_k127_3642101_4	656519.Halsa_1654	2.108e-29	123.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,3WBQ3@53433|Halanaerobiales	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
EH3_k127_3642101_2	1146883.BLASA_5012	2.181e-63	233.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
EH3_k127_3642101_5	883.DvMF_3201	2.508e-21	95.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2M7WJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
EH3_k127_3662136_3	2074.JNYD01000005_gene3235	1.587e-07	55.0	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria,4E724@85010|Pseudonocardiales	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
EH3_k127_3662136_1	1214242.B446_34600	2.776e-73	276.0	COG1226@1|root,COG1226@2|Bacteria,2GKB8@201174|Actinobacteria	201174|Actinobacteria	P	Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
EH3_k127_3662136_0	589924.Ferp_2555	6.145e-99	348.0	COG0183@1|root,arCOG01279@2157|Archaea,2Y2G9@28890|Euryarchaeota,246XN@183980|Archaeoglobi	183980|Archaeoglobi	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
EH3_k127_3662136_2	1122939.ATUD01000021_gene4066	2.884e-08	66.0	COG0346@1|root,COG0346@2|Bacteria,2GPM4@201174|Actinobacteria,4CTJV@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
EH3_k127_3662136_4	1379698.RBG1_1C00001G1464	1.559e-06	53.0	COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	ltp4	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C
EH3_k127_3742729_5	1449976.KALB_2458	1.741e-15	78.0	COG0842@1|root,COG0842@2|Bacteria,2GJ2G@201174|Actinobacteria,4E1IX@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
EH3_k127_3742729_2	525909.Afer_0976	7.308e-46	185.0	COG2210@1|root,COG2210@2|Bacteria,2IGW8@201174|Actinobacteria,4CNFN@84992|Acidimicrobiia	84992|Acidimicrobiia	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
EH3_k127_3742729_4	101510.RHA1_ro11227	5.763e-19	89.0	COG0425@1|root,COG0425@2|Bacteria,2HICA@201174|Actinobacteria,4G3Q7@85025|Nocardiaceae	201174|Actinobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
EH3_k127_3742729_3	305900.GV64_00005	2.643e-28	129.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,He_PIG,HemolysinCabind
EH3_k127_3742729_6	1944.JOAZ01000017_gene3678	1.202e-11	72.0	COG0681@1|root,COG0681@2|Bacteria,2IFS4@201174|Actinobacteria,41B2V@629295|Streptomyces griseus group	201174|Actinobacteria	U	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
EH3_k127_3742729_1	298654.FraEuI1c_0811	6.721e-60	209.0	293MU@1|root,2ZR3M@2|Bacteria,2IFCB@201174|Actinobacteria,4ESJ1@85013|Frankiales	201174|Actinobacteria	Q	Superoxide dismutase	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
EH3_k127_3742729_0	1089545.KB913037_gene798	5.468e-129	428.0	COG0477@1|root,COG0477@2|Bacteria,2GK8M@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH3_k127_3742729_7	469383.Cwoe_3465	1.808e-09	67.0	COG2452@1|root,COG3585@1|root,COG2452@2|Bacteria,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4CQRP@84995|Rubrobacteria	84995|Rubrobacteria	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	MerR,TOBE
EH3_k127_3826819_1	1380391.JIAS01000003_gene1909	1.846e-174	582.0	COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JV15@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
EH3_k127_3826819_0	931627.MycrhDRAFT_3645	7.917e-232	729.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae	201174|Actinobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
EH3_k127_3826819_10	1136417.AZWE01000018_gene948	1.036e-26	123.0	COG1309@1|root,COG1309@2|Bacteria,2GP3D@201174|Actinobacteria,4DD5T@85008|Micromonosporales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
EH3_k127_3826819_12	316274.Haur_4171	7.286e-05	54.0	COG4283@1|root,COG4283@2|Bacteria,2G9ST@200795|Chloroflexi	2|Bacteria	S	Protein of unknown function (DUF1706)	M1-431	-	-	-	-	-	-	-	-	-	-	-	DUF1706
EH3_k127_3826819_2	1380391.JIAS01000011_gene5426	1.258e-158	508.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
EH3_k127_3826819_11	1007103.AFHW01000046_gene2801	6.758e-10	70.0	COG0697@1|root,COG0697@2|Bacteria,1VPVG@1239|Firmicutes,4HSM2@91061|Bacilli,2727M@186822|Paenibacillaceae	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_3826819_7	479434.Sthe_0533	2.656e-86	315.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
EH3_k127_3826819_9	460265.Mnod_0806	1.388e-64	231.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JT04@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
EH3_k127_3826819_6	981369.JQMJ01000004_gene3845	3.001e-92	327.0	COG0687@1|root,COG0687@2|Bacteria,2HPJT@201174|Actinobacteria,2NKQJ@228398|Streptacidiphilus	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
EH3_k127_3826819_8	710687.KI912270_gene394	1.64e-85	295.0	COG1176@1|root,COG1176@2|Bacteria,2IBQM@201174|Actinobacteria,23823@1762|Mycobacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_3826819_5	931627.MycrhDRAFT_3651	8.594e-98	332.0	COG1177@1|root,COG1177@2|Bacteria,2HXTT@201174|Actinobacteria,237JY@1762|Mycobacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_3826819_3	1380391.JIAS01000013_gene3519	6.172e-149	481.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQQC@204441|Rhodospirillales	204441|Rhodospirillales	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
EH3_k127_3826819_4	204669.Acid345_1535	1.511e-146	473.0	COG1012@1|root,COG1012@2|Bacteria,3Y384@57723|Acidobacteria,2JIA8@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85	ko:K00128,ko:K00130,ko:K00146,ko:K10217	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00362,ko00380,ko00410,ko00561,ko00620,ko00622,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00362,map00380,map00410,map00561,map00620,map00622,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130,map01220	M00038,M00135,M00555,M00569	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02762,R02940,R02957,R03283,R03869,R03889,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05353,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00254,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
EH3_k127_3845655_13	1032480.MLP_45100	0.000131	49.0	COG3583@1|root,COG3583@2|Bacteria,2H4RU@201174|Actinobacteria,4DMZZ@85009|Propionibacteriales	201174|Actinobacteria	M	G5	rlpA	-	-	ko:K21688	-	-	-	-	ko00000	-	-	-	DUF348,G5,Transglycosylas
EH3_k127_3845655_6	298654.FraEuI1c_0613	6.568e-56	205.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4ES85@85013|Frankiales	201174|Actinobacteria	L	TIGRFAM hydrolase, TatD family	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
EH3_k127_3845655_0	1120950.KB892810_gene7206	1.119e-185	595.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4DNQ0@85009|Propionibacteriales	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
EH3_k127_3845655_9	1120949.KB903294_gene3852	3.722e-29	128.0	COG5549@1|root,COG5549@2|Bacteria,2IPFT@201174|Actinobacteria	201174|Actinobacteria	O	Matrixin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
EH3_k127_3845655_4	1496688.ER33_15635	2.101e-66	238.0	COG0313@1|root,COG0313@2|Bacteria,1G0IF@1117|Cyanobacteria,22RNS@167375|Cyanobium	1117|Cyanobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
EH3_k127_3845655_10	1206741.BAFX01000113_gene7290	8.425e-29	123.0	2DMMQ@1|root,32SHK@2|Bacteria,2IHWW@201174|Actinobacteria,4G2S5@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
EH3_k127_3845655_3	1463854.JOHT01000010_gene176	2.956e-78	280.0	COG1928@1|root,COG1928@2|Bacteria,2I2H1@201174|Actinobacteria	201174|Actinobacteria	O	PFAM glycosyl transferase family 39	pmt	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_4TMC
EH3_k127_3845655_1	1298863.AUEP01000008_gene1263	4.507e-167	546.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,4DQAW@85009|Propionibacteriales	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
EH3_k127_3845655_7	219305.MCAG_02710	2.461e-54	199.0	COG1266@1|root,COG1266@2|Bacteria,2GK11@201174|Actinobacteria,4D8SM@85008|Micromonosporales	201174|Actinobacteria	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
EH3_k127_3845655_8	1120950.KB892790_gene2070	3.218e-42	157.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria,4DV0A@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
EH3_k127_3845655_12	469383.Cwoe_1973	7.804e-21	105.0	COG4709@1|root,COG4709@2|Bacteria,2GXX9@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3845655_5	690850.Desaf_2977	6.683e-63	224.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2M9ST@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
EH3_k127_3845655_11	994479.GL877878_gene334	1.102e-23	104.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4E5C4@85010|Pseudonocardiales	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH3_k127_3845655_2	469383.Cwoe_4885	2.769e-104	347.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria,4CSK6@84995|Rubrobacteria	84995|Rubrobacteria	G	glycoside hydrolase family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
EH3_k127_3849975_4	196162.Noca_2395	8.03e-85	297.0	COG0265@1|root,COG0265@2|Bacteria,2IE8E@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,Trypsin_2
EH3_k127_3849975_9	1274.HX89_11075	2.391e-26	117.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,1ZVWG@145357|Dermacoccaceae	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
EH3_k127_3849975_12	552811.Dehly_0528	2.254e-23	108.0	COG0558@1|root,COG0558@2|Bacteria,2G6ZT@200795|Chloroflexi,34D5W@301297|Dehalococcoidia	301297|Dehalococcoidia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
EH3_k127_3849975_11	266117.Rxyl_2821	3.211e-24	106.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
EH3_k127_3849975_0	1382356.JQMP01000001_gene1155	2.34e-185	590.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi,27XSD@189775|Thermomicrobia	189775|Thermomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_3849975_2	1463825.JNXC01000023_gene4853	1.844e-138	453.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DYZC@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_3849975_7	235985.BBPN01000014_gene5516	1.563e-36	142.0	COG3795@1|root,COG3795@2|Bacteria,2IQXT@201174|Actinobacteria,2NJNR@228398|Streptacidiphilus	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
EH3_k127_3849975_1	1075090.GOAMR_33_00710	6.571e-179	567.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4GC5F@85026|Gordoniaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
EH3_k127_3849975_3	33876.JNXY01000006_gene1147	1.436e-126	435.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4DCEF@85008|Micromonosporales	201174|Actinobacteria	E	Glycine D-amino acid oxidases (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_3849975_6	309801.trd_A0868	4.91e-62	224.0	COG1194@1|root,COG1194@2|Bacteria,2G62P@200795|Chloroflexi,27XJQ@189775|Thermomicrobia	189775|Thermomicrobia	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
EH3_k127_3849975_10	298653.Franean1_5253	1.596e-24	119.0	COG5662@1|root,COG5662@2|Bacteria,2I5I1@201174|Actinobacteria,4EXC3@85013|Frankiales	201174|Actinobacteria	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
EH3_k127_3849975_5	1134445.AJJM01000056_gene2181	2.492e-75	265.0	COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
EH3_k127_3849975_8	1120950.KB892708_gene4507	1.895e-36	145.0	COG1515@1|root,COG1515@2|Bacteria,2GJEZ@201174|Actinobacteria,4DUVR@85009|Propionibacteriales	201174|Actinobacteria	L	Endonuclease V	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
EH3_k127_395040_2	1385520.N802_06740	1.38e-76	273.0	COG2234@1|root,COG2234@2|Bacteria,2IDP0@201174|Actinobacteria,4FE57@85021|Intrasporangiaceae	201174|Actinobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
EH3_k127_395040_0	243231.GSU1538	1.501e-148	483.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
EH3_k127_395040_4	1144275.COCOR_04568	1.536e-14	88.0	COG2234@1|root,COG2234@2|Bacteria,1R77P@1224|Proteobacteria	1224|Proteobacteria	N	Aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
EH3_k127_395040_3	526225.Gobs_3640	9.768e-31	128.0	2BIEE@1|root,32T9G@2|Bacteria,2I86Y@201174|Actinobacteria,4EXJ3@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_395040_5	1341151.ASZU01000014_gene2204	7.827e-07	60.0	298S5@1|root,2ZVWF@2|Bacteria,1V8I3@1239|Firmicutes,4HHTT@91061|Bacilli,27CFI@186824|Thermoactinomycetaceae	91061|Bacilli	S	Protein of unknown function with PCYCGC motif	-	-	-	-	-	-	-	-	-	-	-	-	PCYCGC
EH3_k127_395040_1	1906.SFRA_16450	2.248e-81	280.0	COG0745@1|root,COG0745@2|Bacteria,2I8R2@201174|Actinobacteria	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
EH3_k127_395040_6	134676.ACPL_5064	7.189e-05	53.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4DAKM@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_3987764_4	1122138.AQUZ01000038_gene7948	0.0008719	53.0	COG1501@1|root,COG3669@1|root,COG1501@2|Bacteria,COG3669@2|Bacteria,2I9R1@201174|Actinobacteria	201174|Actinobacteria	G	Alpha galactosidase A	-	-	-	-	-	-	-	-	-	-	-	-	CBM_X2,Melibiase_2
EH3_k127_3987764_3	1463821.JOGR01000003_gene786	2.188e-37	163.0	COG3757@1|root,COG3757@2|Bacteria,2GKS0@201174|Actinobacteria,4EY4F@85014|Glycomycetales	201174|Actinobacteria	M	PFAM glycoside hydrolase family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
EH3_k127_3987764_0	235909.GK2774	1.367e-98	334.0	COG1062@1|root,COG1062@2|Bacteria,1TP8E@1239|Firmicutes,4HAH9@91061|Bacilli,1WG1U@129337|Geobacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284,1.1.1.90	ko:K00055,ko:K00121	ko00010,ko00071,ko00350,ko00360,ko00622,ko00623,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00360,map00622,map00623,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	M00537,M00538	R00623,R00754,R01763,R02124,R02611,R04304,R04880,R05233,R05234,R05282,R05347,R05348,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
EH3_k127_3987764_1	1380347.JNII01000005_gene3108	5.592e-73	255.0	COG1917@1|root,COG2114@1|root,COG1917@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	lipJ	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
EH3_k127_3987764_2	1385519.N801_05270	3.488e-38	148.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
EH3_k127_4002115_0	269800.Tfu_2490	1.962e-317	994.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4EGCZ@85012|Streptosporangiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
EH3_k127_4002115_1	479434.Sthe_0598	6.741e-51	194.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi	200795|Chloroflexi	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
EH3_k127_4012842_3	1157632.AQWQ01000010_gene742	3.862e-60	215.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
EH3_k127_4012842_0	477974.Daud_1563	1.206e-82	294.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,2608W@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the phosphoenolpyruvate carboxykinase (ATP) family	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
EH3_k127_4012842_4	760568.Desku_0545	1.802e-58	217.0	COG0611@1|root,COG0611@2|Bacteria,1V0SM@1239|Firmicutes,24J04@186801|Clostridia,262KV@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
EH3_k127_4012842_1	932678.THERU_05380	2.843e-79	274.0	COG0351@1|root,COG0351@2|Bacteria	2|Bacteria	H	phosphomethylpyrimidine kinase activity	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7,4.1.99.17	ko:K00941,ko:K03147,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R03472,R04509,R10712	RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2909	Phos_pyr_kin,TMP-TENI
EH3_k127_4012842_5	1203556.HMPREF1478_01971	1.59e-26	115.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4D6AF@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
EH3_k127_4012842_6	378806.STAUR_3689	8.451e-25	113.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
EH3_k127_4012842_2	1313172.YM304_18530	2.345e-65	239.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CMPC@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
EH3_k127_4137482_3	1416759.AYMR01000042_gene1948	5.796e-58	214.0	COG1228@1|root,COG1228@2|Bacteria,2IISK@201174|Actinobacteria,4FNWF@85023|Microbacteriaceae	201174|Actinobacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH3_k127_4137482_2	1382306.JNIM01000001_gene1964	1.024e-87	304.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	ycbU	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
EH3_k127_4137482_4	1394178.AWOO02000050_gene6234	4.086e-24	105.0	2E8UC@1|root,3334W@2|Bacteria,2GPHR@201174|Actinobacteria,4EK6N@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4137482_1	1123261.AXDW01000015_gene3461	1.911e-123	413.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1X53Q@135614|Xanthomonadales	135614|Xanthomonadales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
EH3_k127_4137482_0	644966.Tmar_0209	0.0	1300.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3WCFP@538999|Clostridiales incertae sedis	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
EH3_k127_4156790_0	1122138.AQUZ01000085_gene8823	4.243e-157	510.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4DPHI@85009|Propionibacteriales	201174|Actinobacteria	M	Exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
EH3_k127_4156790_2	67373.JOBF01000034_gene5028	1.892e-143	460.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH3_k127_4156790_6	219305.MCAG_00296	4.122e-47	191.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,4DAW3@85008|Micromonosporales	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
EH3_k127_4156790_4	1894.JOER01000036_gene3185	3.782e-85	287.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
EH3_k127_4156790_3	1304874.JAFY01000002_gene574	5.501e-90	330.0	COG5598@1|root,COG5598@2|Bacteria,3TC8U@508458|Synergistetes	508458|Synergistetes	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
EH3_k127_4156790_8	42256.RradSPS_1042	4.161e-16	81.0	COG4118@1|root,COG4118@2|Bacteria,2HRUG@201174|Actinobacteria,4CTXW@84995|Rubrobacteria	84995|Rubrobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
EH3_k127_4156790_7	525368.HMPREF0591_2104	8.888e-19	93.0	COG1848@1|root,COG1848@2|Bacteria,2GRA5@201174|Actinobacteria,23BD7@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
EH3_k127_4156790_1	1298863.AUEP01000001_gene755	6.032e-147	486.0	COG3021@1|root,COG3021@2|Bacteria,2IMSN@201174|Actinobacteria,4DWIK@85009|Propionibacteriales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
EH3_k127_4156790_9	909663.KI867150_gene2013	1.706e-12	79.0	COG1426@1|root,COG1426@2|Bacteria,1Q29D@1224|Proteobacteria,437BA@68525|delta/epsilon subdivisions,2WS2J@28221|Deltaproteobacteria,2MQQ8@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
EH3_k127_4156790_5	931626.Awo_c20220	1.879e-50	193.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
EH3_k127_4180805_17	749927.AMED_8627	5.452e-09	67.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
EH3_k127_4180805_19	1158182.KB905024_gene73	4.846e-07	59.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1WX0E@135613|Chromatiales	135613|Chromatiales	U	PEP-CTERM system TPR-repeat lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_8
EH3_k127_4180805_21	1382359.JIAL01000001_gene472	0.0001615	53.0	COG0760@1|root,COG0760@2|Bacteria,3Y3V9@57723|Acidobacteria,2JICA@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
EH3_k127_4180805_20	502025.Hoch_3578	9.836e-06	57.0	COG3005@1|root,COG3005@2|Bacteria,1QX4N@1224|Proteobacteria,43BXD@68525|delta/epsilon subdivisions,2X786@28221|Deltaproteobacteria,2Z3DX@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
EH3_k127_4180805_7	246194.CHY_0604	2.116e-36	152.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,2527F@186801|Clostridia	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4180805_14	502025.Hoch_6280	1.941e-18	96.0	COG3005@1|root,COG3005@2|Bacteria,1R03H@1224|Proteobacteria,43CQK@68525|delta/epsilon subdivisions,2X7Y1@28221|Deltaproteobacteria,2Z1GR@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
EH3_k127_4180805_12	246194.CHY_0604	3.601e-22	107.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,2527F@186801|Clostridia	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4180805_9	234267.Acid_6208	3.396e-28	124.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3Y4F0@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome b(C-terminal)/b6/petD	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C,Cytochrome_B
EH3_k127_4180805_2	330214.NIDE3889	9.311e-71	246.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3J0Q6@40117|Nitrospirae	2|Bacteria	C	Cytochrome b/b6/petB	qcrC	-	-	ko:K00412,ko:K03888	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B,Cytochrome_CBB3
EH3_k127_4180805_10	234267.Acid_6209	1.858e-24	117.0	COG0723@1|root,COG0723@2|Bacteria,3Y7YJ@57723|Acidobacteria	57723|Acidobacteria	C	Rieske [2Fe-2S] domain	-	-	-	ko:K03886	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
EH3_k127_4180805_11	635013.TherJR_1118	2.538e-23	110.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,24YVE@186801|Clostridia,2672I@186807|Peptococcaceae	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
EH3_k127_4180805_3	479433.Caci_8326	1.008e-56	214.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
EH3_k127_4180805_13	1089553.Tph_c19900	4.035e-22	102.0	COG1959@1|root,COG1959@2|Bacteria,1VF6H@1239|Firmicutes,25N03@186801|Clostridia,42IJY@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
EH3_k127_4180805_16	1382356.JQMP01000003_gene2356	8.466e-15	87.0	COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi,27XRI@189775|Thermomicrobia	189775|Thermomicrobia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
EH3_k127_4180805_0	861299.J421_2742	2.597e-162	535.0	COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cytochrome c-type biogenesis protein CcmF C-terminal	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
EH3_k127_4180805_1	309801.trd_1217	2.82e-72	251.0	COG0755@1|root,COG0755@2|Bacteria,2G6SI@200795|Chloroflexi,27Y6D@189775|Thermomicrobia	189775|Thermomicrobia	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
EH3_k127_4180805_4	552811.Dehly_0439	3.268e-49	184.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
EH3_k127_4180805_5	1121866.AUGK01000005_gene1173	1.169e-46	182.0	COG1131@1|root,COG1131@2|Bacteria,2H5DY@201174|Actinobacteria,4CV85@84998|Coriobacteriia	84998|Coriobacteriia	V	PFAM ABC transporter	-	-	3.6.3.41,3.6.3.7	ko:K01990,ko:K02193,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254,M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.107,3.A.1.115	-	-	ABC_tran,Rad17
EH3_k127_4180805_15	525904.Tter_1506	2.569e-16	85.0	COG2332@1|root,COG2332@2|Bacteria,2NQ2A@2323|unclassified Bacteria	2|Bacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
EH3_k127_4180805_8	300852.55773110	1.939e-35	144.0	COG0526@1|root,COG0526@2|Bacteria,1WJ2P@1297|Deinococcus-Thermus	2|Bacteria	CO	periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily	dsbE	-	-	ko:K02199,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
EH3_k127_4180805_18	1121413.JMKT01000008_gene1210	3.712e-07	59.0	2EJN9@1|root,33DD4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4180805_6	246969.TAM4_2088	3.758e-44	164.0	COG0535@1|root,arCOG00940@2157|Archaea,2XTQH@28890|Euryarchaeota,243CB@183968|Thermococci	28890|Euryarchaeota	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
EH3_k127_4190939_5	222534.KB893718_gene2243	1.388e-24	107.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4EXBW@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
EH3_k127_4190939_2	1048339.KB913029_gene1641	1.026e-61	231.0	COG2270@1|root,COG2270@2|Bacteria,2GK5A@201174|Actinobacteria,4ERM2@85013|Frankiales	201174|Actinobacteria	S	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH3_k127_4190939_3	1445613.JALM01000020_gene4857	1.217e-53	201.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	2.7.1.119	ko:K17880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	APH
EH3_k127_4190939_0	356851.JOAN01000004_gene1080	1.529e-170	553.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4DAG6@85008|Micromonosporales	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
EH3_k127_4190939_4	1906.SFRA_12660	1.367e-40	158.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
EH3_k127_4190939_1	1380356.JNIK01000013_gene3956	7.961e-69	239.0	COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria,4ESS3@85013|Frankiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Acetyltransf_3,Pyridox_ox_2
EH3_k127_4233547_2	292459.STH3140	3.735e-67	233.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia	186801|Clostridia	J	elongation factor g	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
EH3_k127_4233547_5	1128421.JAGA01000001_gene2006	1.934e-28	122.0	COG2363@1|root,COG2363@2|Bacteria,2NRMS@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF423)	ywdK	-	-	-	-	-	-	-	-	-	-	-	DUF423
EH3_k127_4233547_4	1382306.JNIM01000001_gene1210	4.023e-52	201.0	COG2267@1|root,COG2267@2|Bacteria,2GBHH@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
EH3_k127_4233547_3	2754.EH55_10330	1.068e-53	195.0	COG0537@1|root,COG0537@2|Bacteria,3TB29@508458|Synergistetes	508458|Synergistetes	FG	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
EH3_k127_4233547_0	1313172.YM304_19720	2.327e-218	696.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4CMTQ@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
EH3_k127_4233547_1	656024.FsymDg_2233	2.707e-107	364.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4EXBT@85013|Frankiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH3_k127_4304688_10	1123023.JIAI01000004_gene7846	5.098e-51	187.0	COG1808@1|root,COG1808@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
EH3_k127_4304688_20	479433.Caci_2713	1.264e-24	109.0	COG1808@1|root,COG1808@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
EH3_k127_4304688_22	1121022.ABENE_16855	2.402e-09	68.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2KIWA@204458|Caulobacterales	204458|Caulobacterales	MQ	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
EH3_k127_4304688_16	1382306.JNIM01000001_gene389	2.6e-34	142.0	COG0454@1|root,COG0456@2|Bacteria,2G95I@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH3_k127_4304688_1	338969.Rfer_0150	3.588e-140	456.0	COG4335@1|root,COG4335@2|Bacteria,1P0C1@1224|Proteobacteria,2VISN@28216|Betaproteobacteria,4ADJS@80864|Comamonadaceae	28216|Betaproteobacteria	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation,HEAT
EH3_k127_4304688_21	351607.Acel_1202	2.867e-10	70.0	2BZPH@1|root,33EX8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4304688_19	1183438.GKIL_1766	8.586e-25	111.0	COG2020@1|root,COG2020@2|Bacteria,1G6UG@1117|Cyanobacteria	1117|Cyanobacteria	O	Methyltransferase	ste14	-	-	-	-	-	-	-	-	-	-	-	PEMT
EH3_k127_4304688_7	1121926.AXWO01000017_gene3074	4.531e-95	321.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4EZBA@85014|Glycomycetales	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
EH3_k127_4304688_11	1380390.JIAT01000010_gene4683	3.628e-50	183.0	COG3576@1|root,COG3576@2|Bacteria,2I46F@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
EH3_k127_4304688_26	1499502.EV12_0944	0.0006585	52.0	2DYAZ@1|root,348ZI@2|Bacteria,1GF7Z@1117|Cyanobacteria,1MNUQ@1212|Prochloraceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4304688_9	649638.Trad_2776	2.984e-62	223.0	COG3346@1|root,COG3346@2|Bacteria	2|Bacteria	S	mitochondrial respiratory chain complex IV assembly	surf1	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
EH3_k127_4304688_8	1380391.JIAS01000017_gene563	1.267e-80	276.0	COG1028@1|root,COG1028@2|Bacteria,1RFGR@1224|Proteobacteria	1224|Proteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
EH3_k127_4304688_23	446470.Snas_3206	2.181e-07	55.0	2DRYE@1|root,33DPC@2|Bacteria,2IS24@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4304688_15	471852.Tcur_1674	7.768e-35	144.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4EH3Z@85012|Streptosporangiales	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
EH3_k127_4304688_13	1463825.JNXC01000036_gene3552	5.158e-38	151.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4E04U@85010|Pseudonocardiales	201174|Actinobacteria	GL	phosphoglycerate mutase	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
EH3_k127_4304688_25	345341.KUTG_04140	6.711e-05	46.0	2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4304688_3	68170.KL590535_gene3807	3.178e-113	388.0	COG1506@1|root,COG1680@1|root,COG1506@2|Bacteria,COG1680@2|Bacteria,2GMMM@201174|Actinobacteria,4DYU4@85010|Pseudonocardiales	201174|Actinobacteria	EV	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,PD40,Peptidase_S9
EH3_k127_4304688_5	266117.Rxyl_2548	4.771e-98	338.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4CPF1@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
EH3_k127_4304688_18	67373.JOBF01000004_gene987	5.697e-27	129.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	tcrY	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0036211,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0046983,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_4304688_6	309801.trd_0048	9.701e-97	347.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,2GBGM@200795|Chloroflexi,27YV1@189775|Thermomicrobia	189775|Thermomicrobia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PAS_3
EH3_k127_4304688_2	326427.Cagg_2096	8.706e-135	438.0	COG0022@1|root,COG0022@2|Bacteria,2G5JU@200795|Chloroflexi,374SG@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Transketolase central region	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
EH3_k127_4304688_4	525904.Tter_0093	4.009e-112	371.0	COG1071@1|root,COG1071@2|Bacteria,2NPBB@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	bfmBAA	-	1.2.4.4	ko:K00166,ko:K21416	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS07640	E1_dh
EH3_k127_4304688_17	471852.Tcur_3133	4.672e-27	113.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4EK99@85012|Streptosporangiales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
EH3_k127_4304688_0	1313172.YM304_31890	1.078e-226	728.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CMX3@84992|Acidimicrobiia	84992|Acidimicrobiia	P	E1-E2 ATPase	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K12956	-	-	R00086	RC00002	ko00000,ko01000	3.A.3,3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
EH3_k127_4304688_12	525909.Afer_1305	1.231e-41	168.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4CMY0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Tetratricopeptide repeat	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_20,Thioredoxin
EH3_k127_4304688_14	1463901.JOIY01000035_gene6965	3.326e-37	151.0	COG0500@1|root,COG0500@2|Bacteria,2GKYW@201174|Actinobacteria	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4,Methyltransf_11,NUDIX
EH3_k127_4304688_24	390989.JOEG01000027_gene2211	4.234e-06	51.0	COG3568@1|root,COG3568@2|Bacteria,2GP1E@201174|Actinobacteria,4D8H0@85008|Micromonosporales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
EH3_k127_432090_4	1172188.KB911831_gene3986	8.377e-27	113.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4FE9T@85021|Intrasporangiaceae	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
EH3_k127_432090_3	644283.Micau_2759	5.987e-50	181.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4D8MM@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
EH3_k127_432090_2	395492.Rleg2_2711	1.006e-81	284.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2TRCS@28211|Alphaproteobacteria,4B7JT@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	zinc protease	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
EH3_k127_432090_1	1313172.YM304_13880	5.484e-170	550.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CNIJ@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
EH3_k127_432090_0	1120960.ATXG01000001_gene1075	6.382e-198	627.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4FMB6@85023|Microbacteriaceae	201174|Actinobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
EH3_k127_4322684_8	1380356.JNIK01000014_gene3482	1.507e-10	66.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
EH3_k127_4322684_3	1211815.CBYP010000014_gene3514	2.163e-83	290.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
EH3_k127_4322684_9	291985.CCSI01000002_gene1416	1.085e-08	65.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,2K0P0@204457|Sphingomonadales	204457|Sphingomonadales	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	HAD_2,Virul_fac_BrkB
EH3_k127_4322684_7	42256.RradSPS_2294	5.054e-39	151.0	COG0454@1|root,COG0456@2|Bacteria,2IQQX@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
EH3_k127_4322684_4	1121422.AUMW01000006_gene699	1.293e-67	237.0	COG0586@1|root,COG0586@2|Bacteria,1TS2R@1239|Firmicutes,24HX6@186801|Clostridia,261GD@186807|Peptococcaceae	186801|Clostridia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
EH3_k127_4322684_1	525904.Tter_0485	1.294e-210	683.0	COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
EH3_k127_4322684_2	351607.Acel_1971	7.414e-129	435.0	COG0125@1|root,COG0477@1|root,COG0125@2|Bacteria,COG2814@2|Bacteria,2GNTI@201174|Actinobacteria,4ES48@85013|Frankiales	201174|Actinobacteria	EFGP	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
EH3_k127_4322684_6	390989.JOEG01000010_gene430	1.336e-42	170.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria,4DB0J@85008|Micromonosporales	201174|Actinobacteria	L	DNA polymerase III	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
EH3_k127_4322684_5	1298863.AUEP01000001_gene779	2.853e-67	235.0	COG2197@1|root,COG2197@2|Bacteria,2IIDD@201174|Actinobacteria,4DWNU@85009|Propionibacteriales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
EH3_k127_4322684_0	335283.Neut_0182	1.366e-267	842.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria,3722H@32003|Nitrosomonadales	28216|Betaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,Usp
EH3_k127_4374329_9	469383.Cwoe_4156	1.278e-68	236.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4CP6Q@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH3_k127_4374329_4	2074.JNYD01000022_gene1521	8.045e-102	344.0	COG0709@1|root,COG0709@2|Bacteria,2GNP4@201174|Actinobacteria,4DYK1@85010|Pseudonocardiales	201174|Actinobacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
EH3_k127_4374329_14	644966.Tmar_1104	1.854e-32	130.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia	186801|Clostridia	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
EH3_k127_4374329_3	383372.Rcas_0318	3.725e-113	396.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2G5TN@200795|Chloroflexi,376KE@32061|Chloroflexia	32061|Chloroflexia	HP	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
EH3_k127_4374329_15	1380347.JNII01000006_gene1970	3.22e-27	124.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,4ESZV@85013|Frankiales	201174|Actinobacteria	H	PFAM thiamineS protein	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
EH3_k127_4374329_2	671143.DAMO_1028	8.551e-121	394.0	COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113,2.5.1.47,6.1.1.16	ko:K01883,ko:K12339,ko:K21148	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230,map04122	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859,R10610	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876,RC03225	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	PALP,tRNA-synt_1e
EH3_k127_4374329_7	2074.JNYD01000022_gene1499	3.294e-83	284.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4DX58@85010|Pseudonocardiales	201174|Actinobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
EH3_k127_4374329_11	1944.JOAZ01000015_gene4572	7.603e-54	199.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,41A2J@629295|Streptomyces griseus group	201174|Actinobacteria	S	Beta-lactamase superfamily domain	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
EH3_k127_4374329_8	1437824.BN940_10471	4.813e-73	265.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,3T1QC@506|Alcaligenaceae	28216|Betaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
EH3_k127_4374329_13	1155718.KB891929_gene2565	7.917e-46	185.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
EH3_k127_4374329_6	502025.Hoch_3112	2.27e-88	304.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NAQ@68525|delta/epsilon subdivisions,2WJPX@28221|Deltaproteobacteria,2YX68@29|Myxococcales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Hist_deacetyl
EH3_k127_4374329_0	1123072.AUDH01000001_gene3181	4.225e-218	693.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JR19@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
EH3_k127_4374329_12	159450.NH14_08590	4.964e-46	176.0	COG1504@1|root,COG1504@2|Bacteria,1PIIB@1224|Proteobacteria,2W759@28216|Betaproteobacteria,1KDUX@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
EH3_k127_4374329_10	543632.JOJL01000005_gene4760	1.797e-61	240.0	COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
EH3_k127_4374329_5	1120949.KB903357_gene4836	1.025e-96	346.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4DHP7@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
EH3_k127_4374329_1	1048339.KB913029_gene4749	1.015e-128	434.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4ERYY@85013|Frankiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
EH3_k127_4378405_6	1380354.JIAN01000010_gene2960	1.08e-19	94.0	COG0599@1|root,COG0599@2|Bacteria,2IM93@201174|Actinobacteria	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
EH3_k127_4378405_4	1206726.BAFV01000065_gene4502	1.84e-50	206.0	COG3832@1|root,COG3832@2|Bacteria,2GY9A@201174|Actinobacteria,4G0ZK@85025|Nocardiaceae	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4378405_0	452637.Oter_0981	4.098e-172	552.0	COG2070@1|root,COG2070@2|Bacteria,46UTY@74201|Verrucomicrobia,3K79P@414999|Opitutae	414999|Opitutae	C	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
EH3_k127_4378405_5	1380347.JNII01000007_gene330	1.256e-33	149.0	COG0671@1|root,COG0671@2|Bacteria,2GVMI@201174|Actinobacteria	201174|Actinobacteria	I	phosphoesterase, PA-phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
EH3_k127_4378405_3	1380393.JHVP01000024_gene3309	8.431e-76	268.0	COG0392@1|root,COG0392@2|Bacteria,2ICMJ@201174|Actinobacteria,4ETKK@85013|Frankiales	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
EH3_k127_4378405_1	1380347.JNII01000005_gene3057	4.16e-129	432.0	COG0671@1|root,COG1718@1|root,COG0671@2|Bacteria,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	kdkA	-	2.7.1.166,3.6.1.27	ko:K11211,ko:K19302	ko00540,ko00550,map00540,map00550	-	R05627,R09767	RC00002,RC00078	ko00000,ko00001,ko01000,ko01011	-	-	-	Kdo,PAP2
EH3_k127_4378405_2	756067.MicvaDRAFT_3973	7.684e-128	422.0	COG3391@1|root,COG3409@1|root,COG3391@2|Bacteria,COG3409@2|Bacteria,1G33X@1117|Cyanobacteria,1H9RN@1150|Oscillatoriales	1117|Cyanobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,PG_binding_1
EH3_k127_4391161_7	266940.Krad_1229	1.66e-19	98.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_4391161_6	909613.UO65_3730	6.752e-39	156.0	COG2197@1|root,COG2197@2|Bacteria,2GJ29@201174|Actinobacteria,4E4RN@85010|Pseudonocardiales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
EH3_k127_4391161_5	1193181.BN10_520024	4.036e-41	165.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4FGAV@85021|Intrasporangiaceae	201174|Actinobacteria	K	Chemotaxis protein CheY	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
EH3_k127_4391161_1	1380386.JIAW01000017_gene3191	4.707e-103	344.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,23882@1762|Mycobacteriaceae	201174|Actinobacteria	M	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,GDP_Man_Dehyd
EH3_k127_4391161_9	1324957.K933_07216	0.0009685	48.0	arCOG03232@1|root,arCOG03232@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
EH3_k127_4391161_2	525904.Tter_2814	3.72e-97	332.0	COG0673@1|root,COG0673@2|Bacteria,2NP38@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
EH3_k127_4391161_3	479434.Sthe_1142	4.091e-56	208.0	COG2148@1|root,COG2148@2|Bacteria,2G66B@200795|Chloroflexi,27XNK@189775|Thermomicrobia	200795|Chloroflexi	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
EH3_k127_4391161_0	224324.aq_024	5.484e-116	389.0	COG1004@1|root,COG1004@2|Bacteria,2G3RE@200783|Aquificae	200783|Aquificae	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	nsd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
EH3_k127_4391161_8	443906.CMM_0722	4.418e-09	68.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FM6M@85023|Microbacteriaceae	201174|Actinobacteria	D	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
EH3_k127_4391161_4	489825.LYNGBM3L_22550	1.013e-52	207.0	COG2244@1|root,COG2244@2|Bacteria,1G2BA@1117|Cyanobacteria,1H8SP@1150|Oscillatoriales	1117|Cyanobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
EH3_k127_4408786_2	1194165.CAJF01000023_gene3158	4.711e-44	164.0	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria	201174|Actinobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
EH3_k127_4408786_1	1298863.AUEP01000001_gene755	1.85e-64	241.0	COG3021@1|root,COG3021@2|Bacteria,2IMSN@201174|Actinobacteria,4DWIK@85009|Propionibacteriales	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
EH3_k127_4408786_3	929712.KI912613_gene3853	4.432e-39	162.0	COG0823@1|root,COG0823@2|Bacteria,2I79G@201174|Actinobacteria	201174|Actinobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4408786_0	391600.ABRU01000056_gene579	8.774e-65	241.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,2U6YA@28211|Alphaproteobacteria,2KGUX@204458|Caulobacterales	204458|Caulobacterales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
EH3_k127_4408786_4	316274.Haur_3838	2.18e-16	89.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	HTH_20
EH3_k127_4523498_4	2002.JOEQ01000013_gene5463	9.363e-47	173.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4EGKY@85012|Streptosporangiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
EH3_k127_4523498_1	383372.Rcas_2972	1.101e-72	256.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi,376KK@32061|Chloroflexia	32061|Chloroflexia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
EH3_k127_4523498_3	1386089.N865_21085	5.045e-62	224.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,4FFYF@85021|Intrasporangiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
EH3_k127_4523498_7	547559.Nmag_4143	0.0001412	49.0	arCOG11495@1|root,arCOG11495@2157|Archaea,2XZAM@28890|Euryarchaeota,23XCX@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4523498_0	1380390.JIAT01000010_gene4575	1.176e-101	357.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria	84995|Rubrobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
EH3_k127_4523498_5	1380386.JIAW01000006_gene1093	2.404e-27	124.0	COG0697@1|root,COG0697@2|Bacteria,2ID9Z@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_4523498_2	570268.ANBB01000016_gene3621	5.8e-69	243.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria,4ENHQ@85012|Streptosporangiales	201174|Actinobacteria	S	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
EH3_k127_4523498_6	263358.VAB18032_02035	1.651e-06	55.0	COG2267@1|root,COG2267@2|Bacteria,2I3ZR@201174|Actinobacteria,4DB8U@85008|Micromonosporales	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
EH3_k127_4537862_3	1123251.ATWM01000007_gene2425	3.184e-43	169.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4FE3H@85021|Intrasporangiaceae	201174|Actinobacteria	O	cytochrome C	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
EH3_k127_4537862_6	1120950.KB892801_gene1785	1.925e-41	164.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4DPTU@85009|Propionibacteriales	201174|Actinobacteria	O	cytochrome c biogenesis protein, transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
EH3_k127_4537862_7	1229780.BN381_450012	1.271e-20	97.0	COG1143@1|root,COG1143@2|Bacteria,2H4NQ@201174|Actinobacteria	201174|Actinobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10
EH3_k127_4537862_0	1313172.YM304_04010	9.992e-115	378.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cytochrome b/b6/petB	-	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
EH3_k127_4537862_2	1382306.JNIM01000001_gene1048	4.799e-54	200.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	pcmD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
EH3_k127_4537862_4	1229780.BN381_450009	2.675e-42	166.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria	201174|Actinobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
EH3_k127_4537862_9	1313172.YM304_04040	6.333e-07	59.0	COG2010@1|root,COG2010@2|Bacteria,2H49G@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
EH3_k127_4537862_1	196162.Noca_0493	6.476e-80	273.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4DPX5@85009|Propionibacteriales	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
EH3_k127_4537862_8	1169154.KB897780_gene2546	1.247e-12	70.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria	201174|Actinobacteria	O	PFAM Glutaredoxin 2	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
EH3_k127_4537862_5	68170.KL590578_gene4061	1.844e-41	160.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4E2NI@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70, region 4	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
EH3_k127_4550056_9	1111069.TCCBUS3UF1_3240	1.384e-25	108.0	COG2606@1|root,COG2606@2|Bacteria,1WJSU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	YbaK prolyl-tRNA synthetase associated	ebsC	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
EH3_k127_4550056_6	365528.KB891203_gene3454	1.303e-37	150.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4ESRR@85013|Frankiales	201174|Actinobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
EH3_k127_4550056_0	1394178.AWOO02000021_gene7354	0.0	1592.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4EFW6@85012|Streptosporangiales	201174|Actinobacteria	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
EH3_k127_4550056_11	765420.OSCT_2320	2.015e-17	96.0	COG0664@1|root,COG1994@1|root,COG2905@1|root,COG0664@2|Bacteria,COG1994@2|Bacteria,COG2905@2|Bacteria,2GBJH@200795|Chloroflexi,3761G@32061|Chloroflexia	32061|Chloroflexia	T	PFAM cyclic nucleotide-binding	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	cNMP_binding
EH3_k127_4550056_10	1057002.KB905370_gene3285	4.53e-25	119.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1NARN@1224|Proteobacteria,2U22S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CE	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
EH3_k127_4550056_5	251221.35212182	1.789e-70	250.0	COG0667@1|root,COG0667@2|Bacteria,1G1J4@1117|Cyanobacteria	1117|Cyanobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
EH3_k127_4550056_1	446468.Ndas_5089	5.436e-265	829.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4EFQQ@85012|Streptosporangiales	201174|Actinobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
EH3_k127_4550056_2	66874.JOFS01000017_gene3423	7.197e-137	449.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
EH3_k127_4550056_4	1128421.JAGA01000002_gene997	1.447e-82	300.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
EH3_k127_4550056_13	1027371.GOALK_060_00400	2.886e-13	75.0	COG0784@1|root,COG0784@2|Bacteria,2II71@201174|Actinobacteria,4GE5Y@85026|Gordoniaceae	201174|Actinobacteria	T	response regulator	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Response_reg
EH3_k127_4550056_7	357808.RoseRS_0526	2.293e-30	128.0	2DQ8Q@1|root,335AV@2|Bacteria,2G9D1@200795|Chloroflexi	200795|Chloroflexi	S	pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
EH3_k127_4550056_8	68260.JOAY01000016_gene3400	1.242e-25	122.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH3_k127_4550056_3	1033739.CAEU01000031_gene1673	1.456e-117	390.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,26D7U@186818|Planococcaceae	91061|Bacilli	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
EH3_k127_456238_4	1445613.JALM01000102_gene1527	2.765e-100	334.0	COG2957@1|root,COG2957@2|Bacteria,2GM6J@201174|Actinobacteria,4E46B@85010|Pseudonocardiales	201174|Actinobacteria	E	Porphyromonas-type peptidyl-arginine deiminase	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
EH3_k127_456238_0	1123023.JIAI01000002_gene5803	3.802e-251	794.0	COG0804@1|root,COG0804@2|Bacteria,2GM7X@201174|Actinobacteria,4E041@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
EH3_k127_456238_1	562970.Btus_0349	1.559e-127	421.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4HABI@91061|Bacilli,279GP@186823|Alicyclobacillaceae	91061|Bacilli	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
EH3_k127_456238_3	479433.Caci_5374	3.492e-113	376.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH3_k127_456238_2	1476876.JOJO01000036_gene4370	1.827e-127	415.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
EH3_k127_456238_5	1385518.N798_01500	5.069e-100	340.0	COG1173@1|root,COG1173@2|Bacteria,2GKAW@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH3_k127_456238_6	1122609.AUGT01000009_gene3346	3.789e-91	310.0	COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4DPH9@85009|Propionibacteriales	201174|Actinobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
EH3_k127_4564722_4	946362.XP_004990069.1	5.475e-49	183.0	COG0321@1|root,KOG0325@2759|Eukaryota,39TS9@33154|Opisthokonta	33154|Opisthokonta	CH	octanoyl transferase activity (acting on glycine-cleavage complex H protein)	LIPT2	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009893,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0018065,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031974,GO:0033819,GO:0034641,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051604,GO:0065007,GO:0070013,GO:0071704,GO:1901564,GO:2000374,GO:2000376	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
EH3_k127_4564722_2	234267.Acid_0914	2.115e-113	380.0	COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria	57723|Acidobacteria	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
EH3_k127_4564722_1	330214.NIDE3114	4.065e-116	385.0	COG0022@1|root,COG0022@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	bfmBA	-	1.2.4.4	ko:K00167,ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
EH3_k127_4564722_3	671143.DAMO_0748	7.674e-76	273.0	COG1071@1|root,COG1071@2|Bacteria,2NPBB@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	bfmBA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
EH3_k127_4564722_0	1236902.ANAS01000015_gene533	3.889e-124	410.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4EH93@85012|Streptosporangiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
EH3_k127_4586961_7	1122609.AUGT01000015_gene1968	7.73e-09	60.0	COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria,4DNXG@85009|Propionibacteriales	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
EH3_k127_4586961_4	926550.CLDAP_36970	1.668e-52	196.0	COG1136@1|root,COG1136@2|Bacteria,2G7XA@200795|Chloroflexi	200795|Chloroflexi	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH3_k127_4586961_2	266117.Rxyl_2822	1.779e-113	378.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4CPI4@84995|Rubrobacteria	84995|Rubrobacteria	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
EH3_k127_4586961_6	266117.Rxyl_2821	4.533e-24	108.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
EH3_k127_4586961_5	710111.FraQA3DRAFT_5013	2.141e-35	150.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,4ERU5@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
EH3_k127_4586961_0	401526.TcarDRAFT_2673	1.639e-162	541.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4H327@909932|Negativicutes	909932|Negativicutes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
EH3_k127_4586961_3	1463885.KL578365_gene2732	1.863e-71	255.0	COG0697@1|root,COG0697@2|Bacteria,2I91Y@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_4586961_1	562970.Btus_2801	1.797e-142	460.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,4HBAZ@91061|Bacilli,2782N@186823|Alicyclobacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
EH3_k127_4601221_0	408672.NBCG_00756	3.83e-140	473.0	COG4412@1|root,COG4412@2|Bacteria,2I073@201174|Actinobacteria,4DW1Y@85009|Propionibacteriales	201174|Actinobacteria	S	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4601221_4	28042.GU90_00260	2.69e-52	205.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
EH3_k127_4601221_6	453591.Igni_0598	3.123e-19	94.0	COG0517@1|root,arCOG00606@2157|Archaea,2XQQK@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH3_k127_4601221_2	309799.DICTH_1914	9.286e-111	377.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH3_k127_4601221_10	1150600.ADIARSV_0762	8.682e-09	65.0	COG0312@1|root,COG0312@2|Bacteria,4NG2Y@976|Bacteroidetes,1IRC4@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative modulator of DNA gyrase	tldD1	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH3_k127_4601221_11	192952.MM_2721	6.957e-08	63.0	arCOG05253@1|root,arCOG05253@2157|Archaea,2Y4YF@28890|Euryarchaeota,2NB34@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4601221_3	675635.Psed_6017	5.344e-92	317.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4E1ST@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH3_k127_4601221_5	570268.ANBB01000015_gene3713	1.28e-19	102.0	COG4927@1|root,COG4927@2|Bacteria,2I9GM@201174|Actinobacteria	201174|Actinobacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
EH3_k127_4601221_9	384765.SIAM614_29321	2.482e-09	67.0	COG1413@1|root,COG1413@2|Bacteria,1R4SF@1224|Proteobacteria,2TU29@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PBS lyase HEAT domain protein repeat-containing protein	MA20_14850	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
EH3_k127_4601221_8	1120983.KB894576_gene3431	1.919e-10	72.0	COG3595@1|root,COG3595@2|Bacteria,1QUNK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4601221_1	1125971.ASJB01000099_gene2288	3.542e-115	393.0	COG1131@1|root,COG1131@2|Bacteria,2IBJD@201174|Actinobacteria,4E1YQ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH3_k127_4601221_7	1121272.KB903290_gene4687	6.146e-15	78.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
EH3_k127_4612149_1	1150864.MILUP08_46368	8.167e-19	95.0	COG1595@1|root,COG1595@2|Bacteria,2IHVZ@201174|Actinobacteria,4DDW8@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_4612149_2	309801.trd_1490	4.091e-18	91.0	COG1917@1|root,COG1917@2|Bacteria,2G9S4@200795|Chloroflexi,27ZAD@189775|Thermomicrobia	189775|Thermomicrobia	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
EH3_k127_4612149_0	479434.Sthe_0904	1.455e-56	213.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
EH3_k127_4612149_3	926550.CLDAP_16140	8.629e-16	85.0	COG1215@1|root,COG1215@2|Bacteria,2G6E4@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3,Glycos_transf_2
EH3_k127_4713387_5	1123072.AUDH01000022_gene1093	9.25e-50	188.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,2JRPW@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
EH3_k127_4713387_3	1304880.JAGB01000001_gene574	4.145e-67	244.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
EH3_k127_4713387_2	351607.Acel_1297	9.906e-72	256.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4ESI4@85013|Frankiales	201174|Actinobacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
EH3_k127_4713387_6	292459.STH2803	1.374e-08	62.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24
EH3_k127_4713387_0	1179773.BN6_63180	1.602e-123	409.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4DXZ8@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
EH3_k127_4713387_1	1237500.ANBA01000029_gene4570	1.297e-122	407.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4EH29@85012|Streptosporangiales	201174|Actinobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
EH3_k127_4713387_4	383372.Rcas_2433	8.774e-56	198.0	COG2065@1|root,COG2065@2|Bacteria,2G6WS@200795|Chloroflexi,375J4@32061|Chloroflexia	32061|Chloroflexia	F	Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
EH3_k127_4730077_1	298653.Franean1_6095	3.56e-26	110.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4ERPF@85013|Frankiales	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
EH3_k127_4730077_3	1121933.AUHH01000023_gene975	3.758e-15	82.0	COG3467@1|root,COG3467@2|Bacteria,2IFJS@201174|Actinobacteria,4DQR8@85009|Propionibacteriales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
EH3_k127_4730077_0	446470.Snas_5028	5.48e-52	201.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4EY4D@85014|Glycomycetales	201174|Actinobacteria	H	Polyprenyl synthetase	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
EH3_k127_4730077_2	1283287.KB822579_gene2091	5.97e-23	109.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4DQ6X@85009|Propionibacteriales	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
EH3_k127_4786015_0	1380354.JIAN01000005_gene2490	1.217e-125	418.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4F0QR@85016|Cellulomonadaceae	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
EH3_k127_4786015_1	1283299.AUKG01000001_gene1749	2.683e-62	238.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CQ6E@84995|Rubrobacteria	84995|Rubrobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
EH3_k127_4786015_4	1146883.BLASA_0041	1.346e-25	111.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4ESTH@85013|Frankiales	201174|Actinobacteria	T	FHA domain containing protein	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
EH3_k127_4786015_2	1120936.KB907212_gene4976	2.142e-38	154.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4EFW3@85012|Streptosporangiales	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
EH3_k127_4786015_3	68570.DC74_6671	6.146e-35	139.0	COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria	201174|Actinobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
EH3_k127_4834737_1	883067.HMPREF9237_00930	2.31e-24	109.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4D3EF@85005|Actinomycetales	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
EH3_k127_4834737_2	760568.Desku_1276	3.199e-24	109.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,262DS@186807|Peptococcaceae	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
EH3_k127_4834737_3	469371.Tbis_1418	1.07e-20	97.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria	201174|Actinobacteria	T	Transcriptional regulator, TraR DksA family	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
EH3_k127_4834737_4	1123501.KB902316_gene3006	3.111e-10	64.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
EH3_k127_4834737_0	351607.Acel_1029	2.396e-310	972.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4ERW9@85013|Frankiales	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
EH3_k127_4881456_0	1121377.KB906405_gene136	1.231e-118	403.0	COG4640@1|root,COG4640@2|Bacteria	2|Bacteria	KT	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160,YARHG,zinc_ribbon_2
EH3_k127_4881456_1	1313172.YM304_17360	4.722e-10	64.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K03281,ko:K08714,ko:K16922	-	-	-	-	ko00000,ko01002,ko02000	1.A.1.14,2.A.49	-	-	CBS,Ion_trans,NTP_transferase,TIR-like,cNMP_binding
EH3_k127_489481_4	635013.TherJR_0119	4.44e-16	82.0	COG3391@1|root,COG3391@2|Bacteria,1UW22@1239|Firmicutes,24W73@186801|Clostridia,266DU@186807|Peptococcaceae	186801|Clostridia	M	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
EH3_k127_489481_2	644966.Tmar_0766	1.223e-80	295.0	COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,24IHQ@186801|Clostridia	186801|Clostridia	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
EH3_k127_489481_1	485913.Krac_1479	2.604e-81	282.0	COG0276@1|root,COG0276@2|Bacteria,2G6A2@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the ferrous insertion into protoporphyrin IX	-	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
EH3_k127_489481_0	309801.trd_0048	9.649e-108	372.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,2GBGM@200795|Chloroflexi,27YV1@189775|Thermomicrobia	189775|Thermomicrobia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PAS_3
EH3_k127_489481_3	762983.HMPREF9444_00463	3.771e-31	124.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1Y3FN@135624|Aeromonadales	135624|Aeromonadales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
EH3_k127_4932767_3	247639.MGP2080_09848	1.767e-87	294.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
EH3_k127_4932767_4	1380356.JNIK01000018_gene691	2.226e-77	287.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4ESBZ@85013|Frankiales	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
EH3_k127_4932767_2	1313172.YM304_35550	1.098e-114	387.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
EH3_k127_4932767_0	1229780.BN381_160033	3.941e-174	559.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,3UWBE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
EH3_k127_4932767_1	644966.Tmar_0315	3.705e-148	496.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,3WDAT@538999|Clostridiales incertae sedis	186801|Clostridia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	ndhF	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
EH3_k127_4932767_6	1173022.Cri9333_3478	2.313e-24	112.0	COG0713@1|root,COG0713@2|Bacteria,1G6KK@1117|Cyanobacteria,1HBH9@1150|Oscillatoriales	1117|Cyanobacteria	C	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration	ndhE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K05576	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_q2
EH3_k127_4932767_5	479433.Caci_0850	2.175e-39	152.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
EH3_k127_4969073_1	1304874.JAFY01000002_gene574	5.586e-88	304.0	COG5598@1|root,COG5598@2|Bacteria,3TC8U@508458|Synergistetes	508458|Synergistetes	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
EH3_k127_4969073_2	1386089.N865_04120	3.875e-26	109.0	arCOG05253@1|root,31CTK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YmaF
EH3_k127_4969073_3	445972.ANACOL_01049	5.142e-26	126.0	COG2234@1|root,COG2234@2|Bacteria,1TRWH@1239|Firmicutes,24BM1@186801|Clostridia,3WI61@541000|Ruminococcaceae	186801|Clostridia	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
EH3_k127_4969073_0	981369.JQMJ01000004_gene3844	2.501e-207	675.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,2NF9U@228398|Streptacidiphilus	201174|Actinobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
EH3_k127_4985232_0	1229780.BN381_250091	1.208e-193	630.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,3UWD9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	ERAP1-like C-terminal domain	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
EH3_k127_4985232_1	1150864.MILUP08_46421	1.655e-109	367.0	COG1171@1|root,COG1171@2|Bacteria,2GKCC@201174|Actinobacteria,4D8JB@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-phosphate dependent enzyme	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_4985232_2	178306.PAE1716	7.138e-05	47.0	COG2513@1|root,arCOG00581@2157|Archaea,2XPMR@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
EH3_k127_5015253_0	266117.Rxyl_1558	4.285e-106	359.0	COG0665@1|root,COG0665@2|Bacteria,2I9WR@201174|Actinobacteria,4CSWG@84995|Rubrobacteria	84995|Rubrobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_5015253_1	525904.Tter_2133	4.437e-74	259.0	COG0646@1|root,COG0646@2|Bacteria	2|Bacteria	E	methionine synthase	metH	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
EH3_k127_5088650_4	1089553.Tph_c16170	2.955e-48	180.0	COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,25E7R@186801|Clostridia,42FZK@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
EH3_k127_5088650_6	396014.BF93_08045	7.391e-25	119.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria,4FCIK@85020|Dermabacteraceae	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5088650_0	1121430.JMLG01000002_gene1257	1.781e-233	736.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,260W1@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
EH3_k127_5088650_5	1203602.HMPREF1527_01134	4.67e-31	135.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4CV02@84998|Coriobacteriia	84998|Coriobacteriia	L	Hydrolase, NUDIX family	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
EH3_k127_5088650_2	644283.Micau_2419	1.523e-138	451.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4DA3S@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
EH3_k127_5088650_3	408672.NBCG_02708	9.168e-92	315.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DNSC@85009|Propionibacteriales	201174|Actinobacteria	L	tyrosine recombinase	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
EH3_k127_5088650_7	1463864.JOGO01000003_gene1956	1.563e-13	79.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria	201174|Actinobacteria	T	Transcriptional regulator, TraR DksA family	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
EH3_k127_5088650_1	264732.Moth_1500	4.286e-146	471.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,42F24@68295|Thermoanaerobacterales	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
EH3_k127_5097423_4	247490.KSU1_D0315	5.045e-49	181.0	COG1007@1|root,COG1007@2|Bacteria,2IXC6@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
EH3_k127_5097423_2	106370.Francci3_0552	2.524e-85	293.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4ERU8@85013|Frankiales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
EH3_k127_5097423_1	591157.SSLG_04020	7.478e-87	292.0	COG0377@1|root,COG0377@2|Bacteria,2GJP5@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB2	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
EH3_k127_5097423_5	1394178.AWOO02000003_gene2834	1.778e-38	150.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria,4EIQ6@85012|Streptosporangiales	201174|Actinobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
EH3_k127_5097423_0	469371.Tbis_0318	3.059e-109	370.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4DYNI@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
EH3_k127_5097423_3	469371.Tbis_0320	2.454e-72	248.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,4E32N@85010|Pseudonocardiales	201174|Actinobacteria	C	4Fe-4S dicluster domain	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
EH3_k127_5112171_0	1449069.JMLO01000002_gene4758	1.194e-104	350.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4FYA9@85025|Nocardiaceae	201174|Actinobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
EH3_k127_5112171_6	326427.Cagg_3406	2.138e-21	109.0	COG0526@1|root,COG0526@2|Bacteria,2GACV@200795|Chloroflexi,375FU@32061|Chloroflexia	32061|Chloroflexia	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
EH3_k127_5112171_4	1380390.JIAT01000014_gene6037	1.375e-38	154.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,4CQVT@84995|Rubrobacteria	84995|Rubrobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
EH3_k127_5112171_3	1380390.JIAT01000014_gene6036	3.665e-40	164.0	COG1595@1|root,COG1595@2|Bacteria,2II47@201174|Actinobacteria,4CSB0@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_5112171_1	1128421.JAGA01000003_gene3532	1.904e-76	273.0	COG5032@1|root,COG5032@2|Bacteria,2NR1S@2323|unclassified Bacteria	2|Bacteria	BDLTU	phosphatidylinositol kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	PI3_PI4_kinase
EH3_k127_5112171_5	926569.ANT_04570	1.147e-30	134.0	298YA@1|root,2ZW25@2|Bacteria,2G6UQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
EH3_k127_5112171_2	1128421.JAGA01000003_gene3534	2.252e-47	176.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.3,3.1.3.73,5.4.2.12	ko:K02226,ko:K15634,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
EH3_k127_5113294_8	1157490.EL26_10410	1.698e-17	91.0	COG2217@1|root,COG2217@2|Bacteria,1VJJE@1239|Firmicutes,4HM5J@91061|Bacilli,278HV@186823|Alicyclobacillaceae	91061|Bacilli	P	Heavy metal translocating P-type atpase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5113294_4	222534.KB893739_gene1434	8.068e-49	192.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria,4ERMT@85013|Frankiales	201174|Actinobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH3_k127_5113294_1	266117.Rxyl_0791	1.18e-63	233.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria,4CPVH@84995|Rubrobacteria	84995|Rubrobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
EH3_k127_5113294_6	1120999.JONM01000001_gene1369	5.656e-36	147.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
EH3_k127_5113294_7	472759.Nhal_1060	1.574e-35	147.0	COG1341@1|root,COG1341@2|Bacteria,1NBYH@1224|Proteobacteria,1SN5N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	mRNA cleavage and polyadenylation factor CLP1 P-loop	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
EH3_k127_5113294_3	351607.Acel_0245	1.929e-51	194.0	2EBHZ@1|root,335IE@2|Bacteria,2GNMR@201174|Actinobacteria,4EV8Z@85013|Frankiales	201174|Actinobacteria	S	Phosphatase	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	-	-	-	-	-	-	-	-	-	-	Phosphatase
EH3_k127_5113294_2	65497.JODV01000010_gene2673	8.363e-55	203.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria,4E57Z@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
EH3_k127_5113294_5	543728.Vapar_0808	1.195e-44	175.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2VJE8@28216|Betaproteobacteria,4AEAF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
EH3_k127_5113294_0	1996.JOFO01000003_gene6242	7.558e-95	325.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4EFJS@85012|Streptosporangiales	201174|Actinobacteria	G	Pyruvate kinase, barrel domain	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
EH3_k127_5118866_11	330214.NIDE3395	1.903e-05	49.0	COG2104@1|root,COG2104@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
EH3_k127_5118866_3	644966.Tmar_2076	2.86e-104	351.0	COG0037@1|root,COG0037@2|Bacteria,1UB13@1239|Firmicutes,249NH@186801|Clostridia	186801|Clostridia	H	Belongs to the TtcA family	-	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
EH3_k127_5118866_6	2074.JNYD01000001_gene6122	2.025e-79	278.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4DX8Q@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
EH3_k127_5118866_0	656024.FsymDg_2227	4.486e-236	743.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4ERPJ@85013|Frankiales	201174|Actinobacteria	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
EH3_k127_5118866_2	298655.KI912266_gene3656	4.716e-186	593.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4ERN8@85013|Frankiales	201174|Actinobacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
EH3_k127_5118866_10	671143.DAMO_0690	1.512e-11	67.0	2E9C2@1|root,30ZT9@2|Bacteria,2NRQ4@2323|unclassified Bacteria	2|Bacteria	S	Pup-like protein	-	-	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
EH3_k127_5118866_4	446466.Cfla_2001	3.293e-83	284.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4F0FT@85016|Cellulomonadaceae	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
EH3_k127_5118866_7	196162.Noca_2646	1.906e-72	255.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4DMZ3@85009|Propionibacteriales	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
EH3_k127_5118866_8	485913.Krac_12384	9.243e-31	131.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	yjgM	-	2.3.1.59	ko:K03828,ko:K17840	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF4298
EH3_k127_5118866_1	2002.JOEQ01000002_gene4397	1.52e-220	694.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4EGN1@85012|Streptosporangiales	201174|Actinobacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
EH3_k127_5118866_5	643648.Slip_0448	2.27e-82	287.0	COG3502@1|root,COG3502@2|Bacteria,1TQW1@1239|Firmicutes,24952@186801|Clostridia,42JP4@68298|Syntrophomonadaceae	186801|Clostridia	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
EH3_k127_5118866_9	1122611.KB904018_gene6993	1.135e-22	106.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4EFRP@85012|Streptosporangiales	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
EH3_k127_5129512_7	440512.C211_18604	5.52e-14	84.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S0EK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,Peptidase_M10,Peptidase_M10_C,VWA_2
EH3_k127_5129512_4	525904.Tter_0691	5.96e-44	166.0	COG0691@1|root,COG0691@2|Bacteria,2NPFK@2323|unclassified Bacteria	2|Bacteria	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
EH3_k127_5129512_2	909613.UO65_5372	1.058e-49	191.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4E0J8@85010|Pseudonocardiales	201174|Actinobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
EH3_k127_5129512_1	351607.Acel_1731	8.445e-97	321.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4ERYD@85013|Frankiales	201174|Actinobacteria	D	cell division ATP-binding protein FtsE	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
EH3_k127_5129512_6	525904.Tter_0232	2.319e-35	156.0	COG4485@1|root,COG4485@2|Bacteria,2NP78@2323|unclassified Bacteria	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
EH3_k127_5129512_0	469371.Tbis_0791	1.876e-111	370.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4DZMR@85010|Pseudonocardiales	201174|Actinobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
EH3_k127_5129512_3	35754.JNYJ01000008_gene3275	3.025e-45	187.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4D8KK@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	Peptidase_C14,SBP_bac_5
EH3_k127_5129512_5	68260.JOAY01000034_gene2587	1.121e-37	160.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria	201174|Actinobacteria	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH3_k127_5153221_1	1192034.CAP_7835	1.191e-47	177.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,42V19@68525|delta/epsilon subdivisions,2WSZV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
EH3_k127_5153221_3	953739.SVEN_3487	1.068e-14	83.0	COG4106@1|root,COG4106@2|Bacteria,2GJMG@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	-	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
EH3_k127_5153221_0	105420.BBPO01000011_gene1963	2.451e-104	348.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,2NHNG@228398|Streptacidiphilus	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH3_k127_5153221_2	1089544.KB912942_gene1686	4.613e-28	129.0	COG0842@1|root,COG0842@2|Bacteria,2H2PR@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
EH3_k127_5293580_4	1128421.JAGA01000003_gene2726	6.778e-47	177.0	COG3336@1|root,COG3336@2|Bacteria	2|Bacteria	G	cytochrome c oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
EH3_k127_5293580_5	1313172.YM304_38650	4.351e-09	68.0	2A8HP@1|root,30XJU@2|Bacteria,2HB16@201174|Actinobacteria	201174|Actinobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
EH3_k127_5293580_3	479434.Sthe_1584	1.776e-71	251.0	COG1845@1|root,COG1845@2|Bacteria,2G74U@200795|Chloroflexi,27YE2@189775|Thermomicrobia	189775|Thermomicrobia	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
EH3_k127_5293580_0	1128421.JAGA01000003_gene2730	8.162e-223	706.0	COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	cyoB	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009486,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016682,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0020037,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902494,GO:1902600	1.10.3.10,1.10.3.12,1.9.3.1	ko:K02274,ko:K02298,ko:K02827	ko00190,ko01100,map00190,map01100	M00155,M00416,M00417	R00081,R09492,R11335	RC00016,RC00061,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1
EH3_k127_5293580_1	479434.Sthe_1582	1.463e-94	323.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia	189775|Thermomicrobia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
EH3_k127_5293580_2	656024.FsymDg_4031	1.772e-75	272.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4ESE9@85013|Frankiales	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
EH3_k127_5293580_6	335543.Sfum_0696	1.334e-06	57.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MRK5@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	ResB-like family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
EH3_k127_5298387_5	1032480.MLP_04480	0.0007427	42.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.294,2.7.1.181	ko:K18827	-	-	R10657,R10658	RC00002,RC00003,RC00078,RC03220	ko00000,ko01000,ko01005	-	-	-	Dimerisation2,Methyltransf_11,Methyltransf_2,Methyltransf_23,Methyltransf_25
EH3_k127_5298387_2	266117.Rxyl_0165	1.537e-37	154.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria	201174|Actinobacteria	C	Suf system fes assembly protein, nifu family	sufU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
EH3_k127_5298387_0	266117.Rxyl_0166	8.958e-154	497.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4CPE2@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
EH3_k127_5298387_1	1379698.RBG1_1C00001G0735	5.435e-95	317.0	COG0396@1|root,COG0396@2|Bacteria,2NNYE@2323|unclassified Bacteria	2|Bacteria	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
EH3_k127_5298387_4	110319.CF8_2138	4.457e-19	95.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4DRMD@85009|Propionibacteriales	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
EH3_k127_5298387_3	525904.Tter_1697	2.132e-37	143.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
EH3_k127_5498138_1	1123023.JIAI01000020_gene2106	1.094e-29	119.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4E076@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
EH3_k127_5498138_0	1123023.JIAI01000020_gene2107	9.204e-139	451.0	COG3383@1|root,COG3383@2|Bacteria,2GKBP@201174|Actinobacteria,4DXFK@85010|Pseudonocardiales	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
EH3_k127_5498138_2	1193181.BN10_230028	4.332e-17	89.0	COG0746@1|root,COG0746@2|Bacteria,2HXM8@201174|Actinobacteria,4FHCJ@85021|Intrasporangiaceae	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
EH3_k127_5498138_3	2002.JOEQ01000043_gene5947	1.896e-10	66.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria,4EJB4@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	ytnP_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH3_k127_5532808_0	1229780.BN381_10012	5.88e-115	386.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,3UWE2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
EH3_k127_5532808_1	68260.JOAY01000050_gene1058	1.44e-110	380.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
EH3_k127_5532808_2	1131462.DCF50_p2906	6.639e-73	253.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,26064@186807|Peptococcaceae	186801|Clostridia	J	TIGRFAM Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
EH3_k127_5659697_12	675635.Psed_2123	3.037e-08	66.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
EH3_k127_5659697_8	867903.ThesuDRAFT_00167	1.365e-54	198.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,3WCIP@538999|Clostridiales incertae sedis	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
EH3_k127_5659697_6	1463887.KL589976_gene5928	2.035e-77	271.0	COG0449@1|root,COG0449@2|Bacteria,2IIQ7@201174|Actinobacteria	201174|Actinobacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
EH3_k127_5659697_4	479437.Elen_1612	3.079e-111	375.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4CUJD@84998|Coriobacteriia	84998|Coriobacteriia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
EH3_k127_5659697_3	555079.Toce_1019	3.076e-144	479.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,42ERE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_5659697_7	706587.Desti_3735	1.916e-69	248.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMP4@28221|Deltaproteobacteria,2MQD5@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
EH3_k127_5659697_5	935866.JAER01000040_gene482	2.87e-79	275.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4DP56@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
EH3_k127_5659697_2	1416759.AYMR01000017_gene2381	4.681e-149	484.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4FK4K@85023|Microbacteriaceae	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
EH3_k127_5659697_0	1117108.PAALTS15_26224	1.432e-167	541.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4HC9J@91061|Bacilli,26RXS@186822|Paenibacillaceae	91061|Bacilli	S	Endoribonuclease that initiates mRNA decay	rny	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
EH3_k127_5659697_11	1193181.BN10_680026	6.021e-15	82.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,4FGQS@85021|Intrasporangiaceae	201174|Actinobacteria	S	Modulates RecA activity	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
EH3_k127_5659697_1	1246995.AFR_35655	1.039e-162	520.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4DAV3@85008|Micromonosporales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
EH3_k127_5659697_9	479434.Sthe_1898	1.18e-23	109.0	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi,27YFE@189775|Thermomicrobia	189775|Thermomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
EH3_k127_5659697_10	1227261.HMPREF0043_01537	2.741e-21	96.0	COG1546@1|root,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4D663@85005|Actinomycetales	201174|Actinobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
EH3_k127_5694897_1	1437882.AZRU01000003_gene1733	1.069e-57	211.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria,1YFM2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_5694897_2	1121946.AUAX01000003_gene1447	1.114e-36	149.0	COG2267@1|root,COG2267@2|Bacteria,2IGKW@201174|Actinobacteria,4DIAN@85008|Micromonosporales	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
EH3_k127_5694897_3	309801.trd_0138	2.788e-11	70.0	COG2329@1|root,COG2329@2|Bacteria,2G9HF@200795|Chloroflexi,27YNW@189775|Thermomicrobia	189775|Thermomicrobia	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
EH3_k127_5694897_0	204669.Acid345_1535	2.009e-67	236.0	COG1012@1|root,COG1012@2|Bacteria,3Y384@57723|Acidobacteria,2JIA8@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85	ko:K00128,ko:K00130,ko:K00146,ko:K10217	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00362,ko00380,ko00410,ko00561,ko00620,ko00622,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00362,map00380,map00410,map00561,map00620,map00622,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130,map01220	M00038,M00135,M00555,M00569	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02762,R02940,R02957,R03283,R03869,R03889,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05353,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00254,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
EH3_k127_5699949_3	593907.Celgi_0218	6.654e-17	81.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4F1FY@85016|Cellulomonadaceae	201174|Actinobacteria	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
EH3_k127_5699949_1	478801.Ksed_19270	6.688e-65	239.0	COG0659@1|root,COG0659@2|Bacteria,2H1V9@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
EH3_k127_5699949_2	882083.SacmaDRAFT_1367	3.624e-35	154.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4DXZX@85010|Pseudonocardiales	201174|Actinobacteria	U	Belongs to the peptidase S26 family	lepB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
EH3_k127_5699949_0	351607.Acel_1545	9.892e-128	421.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4ERWA@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
EH3_k127_5713328_1	1313172.YM304_31600	1.803e-151	503.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4CNHT@84992|Acidimicrobiia	84992|Acidimicrobiia	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
EH3_k127_5713328_4	235985.BBPN01000020_gene6517	8.54e-35	152.0	COG1611@1|root,COG1611@2|Bacteria,2IN1B@201174|Actinobacteria,2NMFW@228398|Streptacidiphilus	201174|Actinobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
EH3_k127_5713328_0	1048339.KB913029_gene1198	2.182e-241	769.0	COG1205@1|root,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4ERHU@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
EH3_k127_5713328_2	1120948.KB903217_gene1079	3.395e-144	470.0	COG0530@1|root,COG0530@2|Bacteria,2GP6H@201174|Actinobacteria,4E18G@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM sodium calcium exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
EH3_k127_5713328_3	1120941.AUBL01000014_gene2503	1.458e-41	168.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4D3R4@85005|Actinomycetales	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
EH3_k127_5747271_1	479435.Kfla_3712	6.589e-123	407.0	COG0769@1|root,COG0769@2|Bacteria,2GME3@201174|Actinobacteria,4DPYG@85009|Propionibacteriales	201174|Actinobacteria	M	Mur ligase middle domain	-	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,TPR_5
EH3_k127_5747271_8	397278.JOJN01000002_gene28	6.214e-26	125.0	COG1734@1|root,COG1734@2|Bacteria,2I086@201174|Actinobacteria,4DW6Z@85009|Propionibacteriales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
EH3_k127_5747271_0	1122609.AUGT01000003_gene2286	0.0	1201.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,2GN0U@201174|Actinobacteria,4DP39@85009|Propionibacteriales	201174|Actinobacteria	HJM	RimK-like ATP-grasp domain	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,Mur_ligase_C,Mur_ligase_M,RimK
EH3_k127_5747271_4	1122609.AUGT01000003_gene2285	8.74e-78	273.0	COG4242@1|root,COG4242@2|Bacteria,2I93U@201174|Actinobacteria,4DP1Z@85009|Propionibacteriales	201174|Actinobacteria	PQ	Peptidase family S51	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
EH3_k127_5747271_9	1349785.BAUG01000044_gene2237	1.005e-14	82.0	2EF10@1|root,338U5@2|Bacteria,4NX1T@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5747271_7	485913.Krac_9471	9.838e-32	131.0	COG5516@1|root,COG5516@2|Bacteria	2|Bacteria	S	CGNR zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
EH3_k127_5747271_6	290397.Adeh_0738	2.341e-61	228.0	COG0122@1|root,COG0122@2|Bacteria,1P0FP@1224|Proteobacteria	1224|Proteobacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
EH3_k127_5747271_10	368407.Memar_1553	2.194e-10	67.0	COG1824@1|root,arCOG00624@2157|Archaea,2XUJE@28890|Euryarchaeota,2NA1G@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM MgtE integral membrane region	-	-	-	ko:K07244	-	-	-	-	ko00000,ko02000	1.A.26.3	-	iAF692.Mbar_A2809	MgtE
EH3_k127_5747271_5	266117.Rxyl_1045	6.477e-76	269.0	COG1824@1|root,COG1824@2|Bacteria,2H441@201174|Actinobacteria	201174|Actinobacteria	P	Integral membrane	-	-	-	-	-	-	-	-	-	-	-	-	MgtE
EH3_k127_5747271_2	266117.Rxyl_1044	3.436e-110	368.0	COG3273@1|root,COG3273@2|Bacteria	2|Bacteria	P	potassium ion transport	-	-	-	-	-	-	-	-	-	-	-	-	GntR,PhoU,TrkA_C
EH3_k127_5747271_11	272844.PAB2062.1n	6.218e-06	55.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZIX@28890|Euryarchaeota,244GR@183968|Thermococci	183968|Thermococci	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH3_k127_5747271_3	1289387.AUKW01000010_gene949	6.52e-80	272.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,polyprenyl_synt
EH3_k127_5748304_6	29306.JOBE01000055_gene91	1.119e-06	61.0	COG1295@1|root,COG1295@2|Bacteria,2H11D@201174|Actinobacteria	201174|Actinobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
EH3_k127_5748304_2	1121946.AUAX01000010_gene3769	1.57e-37	145.0	2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria,4DGA5@85008|Micromonosporales	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N,SHOCT
EH3_k127_5748304_4	58123.JOFJ01000005_gene1300	1.67e-30	128.0	COG0392@1|root,COG0671@1|root,COG3642@1|root,COG0392@2|Bacteria,COG0671@2|Bacteria,COG3642@2|Bacteria,2GMAV@201174|Actinobacteria,4EHD3@85012|Streptosporangiales	201174|Actinobacteria	I	Lysylphosphatidylglycerol synthase TM region	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LPG_synthase_TM,PAP2
EH3_k127_5748304_3	351607.Acel_1691	1.123e-35	147.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4ESZD@85013|Frankiales	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
EH3_k127_5748304_5	28444.JODQ01000011_gene3474	1.766e-17	91.0	2E4AX@1|root,32Z6K@2|Bacteria,2GW4T@201174|Actinobacteria,4EJ1I@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
EH3_k127_5748304_0	383372.Rcas_0224	2.601e-49	181.0	COG2010@1|root,COG2010@2|Bacteria,2G6R3@200795|Chloroflexi,377DZ@32061|Chloroflexia	32061|Chloroflexia	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
EH3_k127_5748304_1	234267.Acid_1867	2.713e-42	162.0	COG0665@1|root,COG0665@2|Bacteria,3Y5BS@57723|Acidobacteria	57723|Acidobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303,ko:K21061	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R00610,R11428	RC00060,RC00135,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
EH3_k127_5760654_0	931627.MycrhDRAFT_4464	5.798e-118	392.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,233TJ@1762|Mycobacteriaceae	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase	pdhB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2496c	Transket_pyr,Transketolase_C
EH3_k127_5760654_1	1896.JOAU01000041_gene1232	3.039e-96	327.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
EH3_k127_5760654_2	326424.FRAAL0133	2.301e-36	158.0	2BPHM@1|root,32IA4@2|Bacteria,2GM2J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5760654_5	1123239.KB898630_gene2582	0.0001078	46.0	2ED1A@1|root,336Y8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5760654_4	1463841.JOIR01000017_gene1779	1.456e-13	75.0	COG1430@1|root,COG1430@2|Bacteria,2IKSE@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
EH3_k127_5760654_3	1121123.AUAO01000003_gene2524	2.026e-25	115.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2KGEZ@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
EH3_k127_5785100_1	1246474.ANBE01000009_gene379	9.45e-44	183.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4EFQT@85012|Streptosporangiales	201174|Actinobacteria	K	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
EH3_k127_5785100_0	886293.Sinac_1689	8.615e-251	803.0	COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
EH3_k127_5785100_2	68170.KL590578_gene4061	3.941e-39	154.0	COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria,4E2NI@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70, region 4	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
EH3_k127_5785100_3	1120948.KB903217_gene820	0.0006305	51.0	COG5343@1|root,COG5343@2|Bacteria,2HM9H@201174|Actinobacteria,4E3TB@85010|Pseudonocardiales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
EH3_k127_5792678_0	33898.JRHJ01000049_gene7703	1.07e-118	398.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH3_k127_5792678_2	1211815.CBYP010000026_gene1176	4.239e-94	333.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4ESHX@85013|Frankiales	201174|Actinobacteria	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH3_k127_5792678_3	469383.Cwoe_0731	4.382e-77	283.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-type Na efflux pump, permease	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
EH3_k127_5792678_4	1120934.KB894436_gene4371	1.069e-18	98.0	COG0346@1|root,COG0346@2|Bacteria,2IQJB@201174|Actinobacteria,4E611@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
EH3_k127_5792678_1	554065.XP_005849246.1	4.865e-109	358.0	COG4992@1|root,KOG1401@2759|Eukaryota,37NS6@33090|Viridiplantae,34GPP@3041|Chlorophyta	2759|Eukaryota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
EH3_k127_5800106_6	749414.SBI_05399	6.674e-08	57.0	2E4NY@1|root,32ZHR@2|Bacteria,2GQPW@201174|Actinobacteria	201174|Actinobacteria	D	involved in cell division	crgA	-	-	-	-	-	-	-	-	-	-	-	CrgA
EH3_k127_5800106_1	1382306.JNIM01000001_gene663	4.873e-159	528.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
EH3_k127_5800106_0	1121468.AUBR01000024_gene3021	8.12e-162	530.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
EH3_k127_5800106_3	390989.JOEG01000009_gene1274	5.569e-41	162.0	COG1011@1|root,COG1011@2|Bacteria,2IAUD@201174|Actinobacteria,4DENN@85008|Micromonosporales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
EH3_k127_5800106_4	1382304.JNIL01000001_gene3039	7.006e-33	140.0	COG0329@1|root,COG0329@2|Bacteria,1TPVS@1239|Firmicutes,4HATJ@91061|Bacilli	91061|Bacilli	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
EH3_k127_5800106_5	1313172.YM304_12130	6.279e-18	95.0	COG0697@1|root,COG0697@2|Bacteria,2GU83@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_5800106_2	660470.Theba_1862	1.676e-65	230.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
EH3_k127_5845099_2	106370.Francci3_0724	6.689e-63	226.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4ESU0@85013|Frankiales	201174|Actinobacteria	GM	Transport permease protein	wzm	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
EH3_k127_5845099_0	1283283.ATXA01000004_gene4345	9.38e-93	330.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4ESAJ@85013|Frankiales	201174|Actinobacteria	GM	PFAM ABC transporter related	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
EH3_k127_5845099_5	383372.Rcas_3972	4.081e-14	82.0	COG2510@1|root,COG2510@2|Bacteria,2GBM1@200795|Chloroflexi,3781W@32061|Chloroflexia	32061|Chloroflexia	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_5845099_3	1435356.Y013_07680	4.986e-52	201.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4FUKN@85025|Nocardiaceae	201174|Actinobacteria	S	Glycosyltransferase like family 2	wbbL	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0045226,GO:0046379,GO:0071704,GO:0071944,GO:1901576	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	iNJ661.Rv3265c	Glyco_tranf_2_3,Glycos_transf_2
EH3_k127_5845099_1	222534.KB893683_gene1160	8.122e-71	252.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4ERNP@85013|Frankiales	201174|Actinobacteria	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
EH3_k127_5845099_4	593907.Celgi_1112	2.585e-45	183.0	COG2385@1|root,COG2385@2|Bacteria,2IEPH@201174|Actinobacteria,4F2HG@85016|Cellulomonadaceae	201174|Actinobacteria	D	SpoIID LytB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LGFP,SpoIID
EH3_k127_5845099_6	1172186.KB911467_gene2073	2.095e-05	57.0	COG5479@1|root,COG5479@2|Bacteria,2GN2D@201174|Actinobacteria,235PA@1762|Mycobacteriaceae	201174|Actinobacteria	M	protein potentially involved in peptidoglycan biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	LGFP
EH3_k127_5918659_2	469371.Tbis_1064	1.022e-75	265.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4DZJ8@85010|Pseudonocardiales	201174|Actinobacteria	S	DHH family	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
EH3_k127_5918659_3	243231.GSU1589	2.73e-22	103.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42U0Y@68525|delta/epsilon subdivisions,2WR00@28221|Deltaproteobacteria,43V4Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
EH3_k127_5918659_5	696281.Desru_2804	6.743e-15	80.0	COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,263AU@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
EH3_k127_5918659_0	635013.TherJR_1377	6.005e-198	639.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,260ER@186807|Peptococcaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
EH3_k127_5918659_4	762963.HMPREF9056_02682	5.577e-17	83.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,4D61T@85005|Actinomycetales	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
EH3_k127_5918659_1	1120985.AUMI01000020_gene1216	6.186e-80	272.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,4H1X2@909932|Negativicutes	909932|Negativicutes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
EH3_k127_6024713_2	298653.Franean1_4336	1.97e-42	162.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH3_k127_6024713_3	864702.OsccyDRAFT_1447	3.491e-32	132.0	COG1510@1|root,COG1510@2|Bacteria,1GDM6@1117|Cyanobacteria,1HFEG@1150|Oscillatoriales	1117|Cyanobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
EH3_k127_6024713_0	330214.NIDE3935	1.127e-44	173.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
EH3_k127_6024713_1	1906.SFRA_32235	1.607e-42	167.0	COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria	201174|Actinobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
EH3_k127_6024713_4	1194165.CAJF01000001_gene2024	7.529e-25	108.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4FKZN@85023|Microbacteriaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
EH3_k127_6042002_1	1122947.FR7_3802	5.803e-36	151.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,4H2FM@909932|Negativicutes	909932|Negativicutes	E	Glutamate formiminotransferase	-	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
EH3_k127_6042002_6	1449058.JQKT01000007_gene1434	4.075e-10	70.0	COG4319@1|root,COG4319@2|Bacteria,2IRHC@201174|Actinobacteria,4FQIA@85023|Microbacteriaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
EH3_k127_6042002_5	710696.Intca_1957	7.948e-11	67.0	2ERD0@1|root,33IYN@2|Bacteria,2GV3G@201174|Actinobacteria,4FHU8@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6042002_0	1348663.KCH_71710	2.729e-80	278.0	COG3705@1|root,COG3705@2|Bacteria,2IC8D@201174|Actinobacteria	201174|Actinobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6042002_3	1330700.JQNC01000003_gene665	9.683e-21	100.0	COG2402@1|root,COG2402@2|Bacteria,1WJXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
EH3_k127_6042002_4	477974.Daud_0414	2.399e-11	69.0	2DSVR@1|root,33HKS@2|Bacteria	2|Bacteria	L	CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,RHH_3,RHH_4
EH3_k127_6042002_2	1236902.ANAS01000004_gene3574	5.694e-21	101.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4EGTB@85012|Streptosporangiales	201174|Actinobacteria	L	Bacterial DNA polymerase III alpha subunit	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
EH3_k127_6089178_4	401526.TcarDRAFT_0013	1.68e-50	184.0	COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,4H3I7@909932|Negativicutes	909932|Negativicutes	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
EH3_k127_6089178_6	1125863.JAFN01000001_gene2314	3.363e-41	160.0	COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,42Q20@68525|delta/epsilon subdivisions,2WP8Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
EH3_k127_6089178_9	1160718.SU9_03061	1.113e-19	104.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
EH3_k127_6089178_10	1313172.YM304_15080	6.676e-14	85.0	2C8AG@1|root,33SQR@2|Bacteria,2H3BF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6089178_13	369723.Strop_2632	4.842e-05	56.0	COG3467@1|root,COG3467@2|Bacteria,2IFJS@201174|Actinobacteria,4DGBB@85008|Micromonosporales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
EH3_k127_6089178_12	469383.Cwoe_5278	4.303e-08	65.0	COG3832@1|root,COG3832@2|Bacteria,2HQWE@201174|Actinobacteria,4CSPB@84995|Rubrobacteria	84995|Rubrobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
EH3_k127_6089178_5	1178537.BA1_11064	7.216e-46	175.0	COG0454@1|root,COG0456@2|Bacteria,1V50M@1239|Firmicutes,4HH63@91061|Bacilli,1ZG7D@1386|Bacillus	91061|Bacilli	K	acetyltransferase	yqjY	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
EH3_k127_6089178_14	592010.GCWU000182_001369	0.0004876	49.0	COG5416@1|root,COG5416@2|Bacteria,1VHTF@1239|Firmicutes,4I628@91061|Bacilli,27E6P@186827|Aerococcaceae	91061|Bacilli	S	Pfam:DUF1049	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
EH3_k127_6089178_11	370438.PTH_1972	1.539e-11	74.0	COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia,2631I@186807|Peptococcaceae	186801|Clostridia	I	PFAM PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
EH3_k127_6089178_8	908337.HMPREF9257_0176	3.422e-22	111.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,4HAT0@91061|Bacilli,27DDB@186827|Aerococcaceae	91061|Bacilli	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
EH3_k127_6089178_1	66869.JNXG01000002_gene6249	5.562e-118	395.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4185V@629295|Streptomyces griseus group	201174|Actinobacteria	D	Iron-sulfur cluster assembly protein	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
EH3_k127_6089178_7	330084.JNYZ01000050_gene8605	1.172e-32	136.0	COG2345@1|root,COG2345@2|Bacteria,2IAWJ@201174|Actinobacteria,4E5TR@85010|Pseudonocardiales	201174|Actinobacteria	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR
EH3_k127_6089178_0	351607.Acel_0550	2.885e-124	411.0	COG2805@1|root,COG2805@2|Bacteria,2HPWY@201174|Actinobacteria,4EUA1@85013|Frankiales	201174|Actinobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
EH3_k127_6089178_2	1121877.JQKF01000003_gene1489	6.217e-98	328.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4CMZ4@84992|Acidimicrobiia	84992|Acidimicrobiia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
EH3_k127_6089178_3	1122182.KB903838_gene4198	1.131e-52	198.0	COG1030@1|root,COG1030@2|Bacteria	2|Bacteria	-	-	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
EH3_k127_6096692_0	1283299.AUKG01000002_gene4371	2.159e-116	394.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4CRH0@84995|Rubrobacteria	84995|Rubrobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH3_k127_6096692_1	561175.KB894093_gene3636	2.502e-11	71.0	2FHIX@1|root,349CW@2|Bacteria,2GN7H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6175422_0	1163409.UUA_08366	7.533e-110	362.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1X3Y7@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH3_k127_6175422_9	1136417.AZWE01000005_gene4535	7.224e-14	83.0	2DPD0@1|root,331J4@2|Bacteria,2IFZU@201174|Actinobacteria,4DCU1@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6175422_11	1410668.JNKC01000016_gene993	0.0001268	44.0	2DES4@1|root,2ZP1M@2|Bacteria,1W3CF@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6175422_3	66429.JOFL01000003_gene3418	4.742e-67	241.0	COG1296@1|root,COG1296@2|Bacteria,2IJ35@201174|Actinobacteria	201174|Actinobacteria	E	AzlC protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
EH3_k127_6175422_5	1267533.KB906736_gene957	5.892e-50	191.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	PhzC-PhzF
EH3_k127_6175422_6	335543.Sfum_3090	4.511e-21	101.0	COG1309@1|root,COG1309@2|Bacteria,1MYVR@1224|Proteobacteria,42SV2@68525|delta/epsilon subdivisions,2WPSA@28221|Deltaproteobacteria,2MRSZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator, TetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
EH3_k127_6175422_4	479431.Namu_0370	5.172e-66	237.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,2HTNU@201174|Actinobacteria,4ETQG@85013|Frankiales	201174|Actinobacteria	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding_2,MerR_1
EH3_k127_6175422_2	1313172.YM304_38300	1.949e-73	262.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
EH3_k127_6175422_1	1313172.YM304_38290	5.299e-86	307.0	COG0577@1|root,COG0577@2|Bacteria,2GMC4@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, permease component	hrtB	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH3_k127_6175422_7	1313172.YM304_38280	4.241e-17	83.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH3_k127_6177156_2	349741.Amuc_1974	1.071e-76	263.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46TNN@74201|Verrucomicrobia,2ITZ4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
EH3_k127_6177156_5	187272.Mlg_1762	2.614e-05	54.0	COG3409@1|root,COG3409@2|Bacteria,1RAFU@1224|Proteobacteria,1S7NF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6177156_3	675635.Psed_4458	1.526e-44	169.0	COG1434@1|root,COG1434@2|Bacteria,2I2NF@201174|Actinobacteria,4E2P9@85010|Pseudonocardiales	201174|Actinobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
EH3_k127_6177156_0	697281.Mahau_0300	6.578e-122	409.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,42ES6@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
EH3_k127_6177156_1	446470.Snas_1799	2.599e-119	404.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4EXQW@85014|Glycomycetales	201174|Actinobacteria	L	DNA primase DnaG DnaB-binding	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
EH3_k127_6177156_4	710111.FraQA3DRAFT_3017	1.007e-39	158.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4ERX9@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
EH3_k127_6182093_3	926550.CLDAP_15320	6.628e-17	90.0	COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi	200795|Chloroflexi	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
EH3_k127_6182093_2	1121017.AUFG01000004_gene3225	4.31e-26	116.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria,4FHCV@85021|Intrasporangiaceae	201174|Actinobacteria	S	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
EH3_k127_6182093_0	479434.Sthe_1357	4.506e-246	775.0	COG1506@1|root,COG1506@2|Bacteria,2G5NN@200795|Chloroflexi,27YSI@189775|Thermomicrobia	189775|Thermomicrobia	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
EH3_k127_6182093_1	1214101.BN159_8075	4.816e-39	153.0	COG2890@1|root,COG2890@2|Bacteria,2GNC1@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the protein N5-glutamine methyltransferase family	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
EH3_k127_6184939_3	356851.JOAN01000003_gene1612	7.197e-29	123.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4D8I4@85008|Micromonosporales	201174|Actinobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
EH3_k127_6184939_2	1123024.AUII01000022_gene110	4.915e-55	205.0	COG0494@1|root,COG2062@1|root,COG0494@2|Bacteria,COG2062@2|Bacteria,2GNRV@201174|Actinobacteria,4EF7E@85010|Pseudonocardiales	201174|Actinobacteria	LT	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
EH3_k127_6184939_0	1519464.HY22_08585	2.341e-69	259.0	COG0248@1|root,COG0248@2|Bacteria,1FDDR@1090|Chlorobi	1090|Chlorobi	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
EH3_k127_6184939_5	1303518.CCALI_01831	0.0003655	51.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,His_Phos_1
EH3_k127_6184939_1	196162.Noca_2624	1.024e-56	210.0	COG0598@1|root,COG0598@2|Bacteria,2GKNZ@201174|Actinobacteria,4DPEQ@85009|Propionibacteriales	201174|Actinobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
EH3_k127_6184939_4	68170.KL590477_gene2360	9.202e-05	45.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4DX3Z@85010|Pseudonocardiales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
EH3_k127_6252846_0	338963.Pcar_0349	1.511e-82	279.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,43USZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2269	3HCDH,3HCDH_N
EH3_k127_6252846_7	298655.KI912266_gene6468	4.116e-14	86.0	COG0477@1|root,COG0477@2|Bacteria,2IDYF@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH3_k127_6252846_1	298655.KI912266_gene6468	7.931e-74	267.0	COG0477@1|root,COG0477@2|Bacteria,2IDYF@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH3_k127_6252846_2	2340.JV46_08060	5.165e-61	218.0	COG3369@1|root,COG3369@2|Bacteria,1RE35@1224|Proteobacteria,1T20P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ferritin-like	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin-like
EH3_k127_6252846_4	1137269.AZWL01000024_gene1037	1.192e-53	201.0	COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria	201174|Actinobacteria	S	Beta-lactamase	ytnP_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH3_k127_6252846_6	1382306.JNIM01000001_gene925	1.173e-15	85.0	2E3KN@1|root,32YIY@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2630)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2630
EH3_k127_6252846_3	110319.CF8_4068	1.709e-60	230.0	COG1409@1|root,COG1409@2|Bacteria,2GP0C@201174|Actinobacteria,4DS7R@85009|Propionibacteriales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	ppe2	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N,TAT_signal
EH3_k127_6252846_5	1463853.JOHW01000015_gene196	2.262e-42	175.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilizers,PPDK_N
EH3_k127_6322882_4	1348663.KCH_30690	8.798e-13	83.0	COG1595@1|root,COG1595@2|Bacteria,2IJH1@201174|Actinobacteria,2M339@2063|Kitasatospora	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_6322882_0	1120949.KB903328_gene8876	3.175e-104	365.0	COG0747@1|root,COG3391@1|root,COG3629@1|root,COG0747@2|Bacteria,COG3391@2|Bacteria,COG3629@2|Bacteria,2GJXH@201174|Actinobacteria	201174|Actinobacteria	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH3_k127_6322882_6	1173029.JH980292_gene4205	4.441e-05	57.0	COG1404@1|root,COG1520@1|root,COG2931@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,1G342@1117|Cyanobacteria,1HH6R@1150|Oscillatoriales	1117|Cyanobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP
EH3_k127_6322882_3	68170.KL590535_gene3752	1.203e-15	86.0	COG4758@1|root,COG4758@2|Bacteria,2HQN6@201174|Actinobacteria,4E9G5@85010|Pseudonocardiales	201174|Actinobacteria	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
EH3_k127_6322882_5	487521.OCU_21310	1.03e-12	78.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,23A4J@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
EH3_k127_6322882_2	1123024.AUII01000006_gene4641	6.602e-17	89.0	2BKPP@1|root,32F5B@2|Bacteria,2GZGW@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_2
EH3_k127_6322882_1	710111.FraQA3DRAFT_5973	1.672e-23	101.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4EXEH@85013|Frankiales	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_6339558_0	479434.Sthe_3420	5.157e-125	416.0	COG1132@1|root,COG1132@2|Bacteria,2G5P7@200795|Chloroflexi,27XZA@189775|Thermomicrobia	189775|Thermomicrobia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
EH3_k127_6339558_3	882086.SacxiDRAFT_4055	1.324e-24	122.0	COG0577@1|root,COG0577@2|Bacteria,2IE56@201174|Actinobacteria,4DYHP@85010|Pseudonocardiales	201174|Actinobacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
EH3_k127_6339558_1	1306174.JODP01000017_gene4243	1.185e-72	262.0	COG1136@1|root,COG1136@2|Bacteria,2IH0C@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
EH3_k127_6339558_2	391625.PPSIR1_35022	3.39e-29	119.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,42SMW@68525|delta/epsilon subdivisions,2WPP1@28221|Deltaproteobacteria,2YUYP@29|Myxococcales	28221|Deltaproteobacteria	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
EH3_k127_6394498_4	348780.NP_3878A	1.265e-25	117.0	COG1397@1|root,arCOG04448@2157|Archaea,2XV15@28890|Euryarchaeota,23TFB@183963|Halobacteria	183963|Halobacteria	O	ADP-ribosyl-(Dinitrogen reductase) hydrolase	-	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
EH3_k127_6394498_2	867903.ThesuDRAFT_01483	6.103e-65	231.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,3WD5B@538999|Clostridiales incertae sedis	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
EH3_k127_6394498_6	159450.NH14_18195	5.201e-06	55.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VMIN@28216|Betaproteobacteria,1K4WF@119060|Burkholderiaceae	28216|Betaproteobacteria	P	p-type atpase	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
EH3_k127_6394498_5	1415756.JQMY01000001_gene3064	9.629e-16	89.0	COG1309@1|root,COG1309@2|Bacteria,1ND64@1224|Proteobacteria,2TTVA@28211|Alphaproteobacteria,2PDEG@252301|Oceanicola	28211|Alphaproteobacteria	K	YcdC-like protein, C-terminal region	rutR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_3,TetR_N
EH3_k127_6394498_1	1120950.KB892707_gene4921	1.221e-86	316.0	COG0204@1|root,COG0204@2|Bacteria,2IAXZ@201174|Actinobacteria,4DPFR@85009|Propionibacteriales	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
EH3_k127_6394498_0	1120950.KB892707_gene4920	7.164e-245	766.0	COG3875@1|root,COG3875@2|Bacteria,2IAM4@201174|Actinobacteria,4DPEW@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
EH3_k127_6394498_3	656024.FsymDg_2369	3.863e-53	190.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,4EWHX@85013|Frankiales	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
EH3_k127_6401973_1	1121877.JQKF01000003_gene1462	1.209e-67	235.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CMQ6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
EH3_k127_6401973_3	1869.MB27_07585	2.434e-28	118.0	2E7YB@1|root,332CR@2|Bacteria,2IRTP@201174|Actinobacteria,4DFX8@85008|Micromonosporales	201174|Actinobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
EH3_k127_6401973_0	1323361.JPOC01000022_gene2938	4.107e-122	397.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4FUIQ@85025|Nocardiaceae	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
EH3_k127_6401973_5	926554.KI912671_gene317	2.683e-13	76.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	3.1.1.45	ko:K01061,ko:K15945	ko00361,ko00364,ko00623,ko01057,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01057,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222,R09330	RC00046,RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	SnoaL,SnoaL_2
EH3_k127_6401973_4	1122138.AQUZ01000017_gene6660	5.348e-14	82.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2,SnoaL_3
EH3_k127_6401973_2	1449346.JQMO01000003_gene2675	1.615e-47	181.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,2M4YS@2063|Kitasatospora	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
EH3_k127_6441584_0	42256.RradSPS_0987	1.038e-75	275.0	COG0297@1|root,COG0297@2|Bacteria,2I4BF@201174|Actinobacteria,4CU41@84995|Rubrobacteria	84995|Rubrobacteria	G	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
EH3_k127_6460216_4	479434.Sthe_3024	4.429e-49	184.0	COG1165@1|root,COG1165@2|Bacteria,2G6JR@200795|Chloroflexi,27XZC@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
EH3_k127_6460216_1	634956.Geoth_0188	5.584e-84	294.0	COG1169@1|root,COG1169@2|Bacteria,1TSRT@1239|Firmicutes,4H9K8@91061|Bacilli,1WEK9@129337|Geobacillus	91061|Bacilli	H	Catalyzes the conversion of chorismate to isochorismate	menF	-	5.4.4.2	ko:K02361,ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
EH3_k127_6460216_2	1313172.YM304_24030	2.207e-73	261.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CN6D@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
EH3_k127_6460216_7	68223.JNZY01000049_gene3450	1.513e-20	100.0	COG0789@1|root,COG0789@2|Bacteria,2GKSZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
EH3_k127_6460216_5	1120949.KB903297_gene5622	1.713e-38	153.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4DD37@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_6460216_3	929712.KI912613_gene1139	5.932e-55	210.0	COG0515@1|root,COG0515@2|Bacteria,2GNG1@201174|Actinobacteria,4CPQV@84995|Rubrobacteria	84995|Rubrobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
EH3_k127_6460216_0	656024.FsymDg_4537	1.307e-104	365.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4ERF4@85013|Frankiales	201174|Actinobacteria	KLT	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	mviN	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
EH3_k127_6460216_8	1123024.AUII01000002_gene858	2.73e-15	90.0	2DUHC@1|root,33QN2@2|Bacteria,2I46X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6460216_6	439481.Aboo_0286	9.762e-31	132.0	COG0730@1|root,arCOG02050@2157|Archaea,2Y68P@28890|Euryarchaeota,3F37D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
EH3_k127_6541354_0	1306174.JODP01000009_gene6611	3.87e-135	437.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
EH3_k127_6541354_5	1313172.YM304_19490	1.059e-05	56.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
EH3_k127_6541354_3	935845.JADQ01000008_gene1918	1.447e-60	221.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,26T5F@186822|Paenibacillaceae	91061|Bacilli	M	cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	iYO844.BSU15230	FAD_binding_4,MurB_C
EH3_k127_6541354_1	570268.ANBB01000002_gene385	4.718e-110	373.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4EG2K@85012|Streptosporangiales	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
EH3_k127_6541354_2	429009.Adeg_1564	4.846e-74	266.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,42F8I@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
EH3_k127_6541354_4	1048339.KB913029_gene4859	5.141e-22	97.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4ERRX@85013|Frankiales	201174|Actinobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
EH3_k127_6557709_2	525904.Tter_2592	7.821e-36	140.0	COG0215@1|root,COG1216@1|root,COG0215@2|Bacteria,COG1216@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
EH3_k127_6557709_0	880072.Desac_2444	2.667e-190	614.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2MQ7P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
EH3_k127_6557709_1	1283283.ATXA01000002_gene2796	5.315e-67	233.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4ES6T@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase sigma factor	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_6557709_3	269800.Tfu_0549	2.091e-13	73.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4EKIJ@85012|Streptosporangiales	201174|Actinobacteria	K	Putative zinc-finger	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
EH3_k127_6600316_11	1120950.KB892708_gene4399	1.803e-25	110.0	COG4274@1|root,COG4274@2|Bacteria,2IN0N@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
EH3_k127_6600316_12	649638.Trad_1790	1.119e-23	113.0	COG4758@1|root,COG4758@2|Bacteria,1WKNW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
EH3_k127_6600316_7	1210045.ALNP01000012_gene1465	5.868e-57	207.0	COG0600@1|root,COG0600@2|Bacteria,2GIWG@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	ssuC3	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
EH3_k127_6600316_3	1007103.AFHW01000091_gene3334	4.958e-81	279.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4HAJC@91061|Bacilli,26RHF@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
EH3_k127_6600316_4	443218.AS9A_3875	7.372e-73	261.0	COG0715@1|root,COG0715@2|Bacteria,2GK7X@201174|Actinobacteria,235U4@1762|Mycobacteriaceae	201174|Actinobacteria	P	NMT1-like family	ssuA3	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
EH3_k127_6600316_1	1254432.SCE1572_42880	4.338e-108	369.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MC0@68525|delta/epsilon subdivisions,2WJIC@28221|Deltaproteobacteria,2YX8D@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25,3.6.3.29,3.6.3.55	ko:K02017,ko:K02045,ko:K15497	ko00920,ko02010,map00920,map02010	M00185,M00189,M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE_2,TOBE_3
EH3_k127_6600316_5	1192034.CAP_7442	6.828e-65	239.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,42ND8@68525|delta/epsilon subdivisions,2WN93@28221|Deltaproteobacteria,2YWH9@29|Myxococcales	28221|Deltaproteobacteria	P	sulfate ABC transporter	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
EH3_k127_6600316_6	1192034.CAP_7443	3.315e-60	220.0	COG4208@1|root,COG4208@2|Bacteria	2|Bacteria	P	ATPase-coupled sulfate transmembrane transporter activity	cysW	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02046,ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	iPC815.YPO3013	BPD_transp_1
EH3_k127_6600316_2	1128421.JAGA01000001_gene2450	2.09e-88	304.0	COG1613@1|root,COG1613@2|Bacteria,2NQGY@2323|unclassified Bacteria	2|Bacteria	P	Bacterial extracellular solute-binding protein	subI	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	iJN678.sbpA	SBP_bac_11
EH3_k127_6600316_0	357808.RoseRS_4538	2.65e-157	502.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi,377XZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
EH3_k127_6600316_8	1417296.U879_09200	2.348e-38	150.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
EH3_k127_6600316_9	570268.ANBB01000004_gene145	1.616e-33	140.0	COG0748@1|root,COG0748@2|Bacteria,2I3CW@201174|Actinobacteria,4EJ2B@85012|Streptosporangiales	201174|Actinobacteria	P	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
EH3_k127_6600316_10	66373.JOFQ01000006_gene2990	1.098e-32	134.0	COG0454@1|root,COG0456@2|Bacteria,2IFMH@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
EH3_k127_6623828_6	1122609.AUGT01000009_gene3341	2.142e-10	63.0	COG0665@1|root,COG0665@2|Bacteria,2I9WR@201174|Actinobacteria,4DRYR@85009|Propionibacteriales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
EH3_k127_6623828_0	591159.ACEZ01000014_gene721	1.982e-177	563.0	COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria	201174|Actinobacteria	E	Saccharopine dehydrogenase	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
EH3_k127_6623828_2	469383.Cwoe_0710	1.153e-130	434.0	COG0531@1|root,COG0531@2|Bacteria,2GMTD@201174|Actinobacteria,4CQQ1@84995|Rubrobacteria	84995|Rubrobacteria	E	COG COG0531 Amino acid transporters Amino acid transport and metabolism	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
EH3_k127_6623828_5	1382356.JQMP01000003_gene2449	2.082e-11	70.0	COG4454@1|root,COG4454@2|Bacteria,2GA6H@200795|Chloroflexi,27YMB@189775|Thermomicrobia	189775|Thermomicrobia	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
EH3_k127_6623828_3	1120950.KB892741_gene2685	6.117e-88	297.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4DPHV@85009|Propionibacteriales	201174|Actinobacteria	Q	Domain of unknown function (DUF2437)	fahA	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
EH3_k127_6623828_1	1449353.JQMQ01000005_gene2063	3.308e-139	462.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,2NEZ8@228398|Streptacidiphilus	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), catalytic domain	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
EH3_k127_6623828_4	1380390.JIAT01000010_gene3555	1.752e-50	198.0	COG3023@1|root,COG3023@2|Bacteria,2HCX7@201174|Actinobacteria,4CQYZ@84995|Rubrobacteria	84995|Rubrobacteria	V	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
EH3_k127_6644193_4	374847.Kcr_0105	6.942e-66	239.0	COG4882@1|root,arCOG02960@2157|Archaea	2157|Archaea	V	Aminopeptidase Iap family-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,Peptidase_M28
EH3_k127_6644193_8	164757.Mjls_1687	7.395e-13	78.0	2DZHZ@1|root,31ZDG@2|Bacteria,2IN6I@201174|Actinobacteria,23A9W@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6644193_0	1229780.BN381_130048	2.218e-240	763.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,3UWC5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
EH3_k127_6644193_6	656024.FsymDg_1645	1.883e-31	134.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4ESQZ@85013|Frankiales	201174|Actinobacteria	M	PFAM peptidase C60, sortase A and B	srtB	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
EH3_k127_6644193_1	298655.KI912266_gene273	9.794e-227	716.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4ERBR@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
EH3_k127_6644193_7	671143.DAMO_2676	7.873e-31	126.0	COG1848@1|root,COG1848@2|Bacteria,2NRZ1@2323|unclassified Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
EH3_k127_6644193_2	1121877.JQKF01000009_gene498	4.025e-182	578.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
EH3_k127_6644193_5	756067.MicvaDRAFT_2068	1.015e-60	227.0	COG0529@1|root,COG0529@2|Bacteria,1G21C@1117|Cyanobacteria,1H93G@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
EH3_k127_6644193_3	886293.Sinac_5883	6.976e-95	317.0	COG3119@1|root,COG3379@1|root,COG3119@2|Bacteria,COG3379@2|Bacteria,2IYF3@203682|Planctomycetes	203682|Planctomycetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
EH3_k127_6667803_5	485913.Krac_2372	1.663e-21	96.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6667803_4	656024.FsymDg_0185	2.95e-64	224.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,4ESIC@85013|Frankiales	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	cypB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
EH3_k127_6667803_0	1380390.JIAT01000009_gene522	3.77e-270	856.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4CP9R@84995|Rubrobacteria	84995|Rubrobacteria	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
EH3_k127_6667803_2	318424.EU78_02890	6.018e-80	301.0	COG0687@1|root,COG0687@2|Bacteria,2IBEC@201174|Actinobacteria,234YK@1762|Mycobacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
EH3_k127_6667803_1	931627.MycrhDRAFT_3650	1.876e-90	308.0	COG1176@1|root,COG1176@2|Bacteria,2IBQM@201174|Actinobacteria,23823@1762|Mycobacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_6667803_3	710687.KI912270_gene393	1.31e-76	279.0	COG1177@1|root,COG1177@2|Bacteria,2HXTT@201174|Actinobacteria,237JY@1762|Mycobacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_6667803_6	1499967.BAYZ01000090_gene4945	4.557e-21	102.0	COG0823@1|root,COG1807@1|root,COG0823@2|Bacteria,COG1807@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641,ko:K08676	-	-	-	-	ko00000,ko01000,ko01002,ko02000	2.C.1.2	-	-	PD40,PMT_2,Peptidase_S41,Tricorn_C1
EH3_k127_6673118_5	1306174.JODP01000002_gene5880	1.956e-61	217.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
EH3_k127_6673118_0	1209984.BN978_03093	5.793e-133	437.0	COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria,233HI@1762|Mycobacteriaceae	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
EH3_k127_6673118_2	465541.ATCJ01000005_gene1908	1.226e-104	347.0	COG0449@1|root,COG0449@2|Bacteria,2I38P@201174|Actinobacteria	201174|Actinobacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	-	-	-	-	-	-	-	-	-	-	SIS
EH3_k127_6673118_4	469383.Cwoe_5798	3.856e-91	306.0	COG1349@1|root,COG1349@2|Bacteria,2GJK9@201174|Actinobacteria,4CU3G@84995|Rubrobacteria	84995|Rubrobacteria	K	DeoR C terminal sensor domain	-	-	-	ko:K02081	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
EH3_k127_6673118_1	1394178.AWOO02000095_gene8232	4.298e-123	408.0	COG2159@1|root,COG2159@2|Bacteria,2IEAH@201174|Actinobacteria	201174|Actinobacteria	S	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
EH3_k127_6673118_6	994573.T472_0201925	7.075e-23	114.0	COG0477@1|root,COG2814@2|Bacteria,1TS3C@1239|Firmicutes,25F93@186801|Clostridia	186801|Clostridia	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
EH3_k127_6673118_3	469383.Cwoe_4885	2.258e-96	322.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria,4CSK6@84995|Rubrobacteria	84995|Rubrobacteria	G	glycoside hydrolase family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
EH3_k127_6680185_3	246196.MSMEI_0503	2.707e-30	123.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,23EXH@1762|Mycobacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
EH3_k127_6680185_1	258533.BN977_04785	3.989e-96	327.0	COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria,23317@1762|Mycobacteriaceae	201174|Actinobacteria	P	ABC transporter	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
EH3_k127_6680185_0	867903.ThesuDRAFT_00861	7.126e-121	398.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WCSJ@538999|Clostridiales incertae sedis	186801|Clostridia	P	Carbohydrate ABC transporter ATP-binding protein, CUT1 family	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
EH3_k127_6680185_2	1382306.JNIM01000001_gene3372	1.167e-66	239.0	COG1131@1|root,COG1131@2|Bacteria,2G6JW@200795|Chloroflexi	200795|Chloroflexi	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH3_k127_6680185_4	717605.Theco_0255	3.083e-08	65.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,4H9MK@91061|Bacilli,26SM3@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter permease	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
EH3_k127_6711460_6	1460634.JCM19037_497	1.03e-40	156.0	COG1522@1|root,COG1522@2|Bacteria,1V319@1239|Firmicutes,4HFNU@91061|Bacilli	91061|Bacilli	K	helix_turn_helix ASNC type	bkdR	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
EH3_k127_6711460_0	1121918.ARWE01000001_gene1360	1.87e-169	552.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
EH3_k127_6711460_4	1451261.AS96_01325	2.391e-47	176.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4FN65@85023|Microbacteriaceae	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
EH3_k127_6711460_7	555079.Toce_0050	2.017e-39	158.0	COG1825@1|root,COG1825@2|Bacteria,1VA38@1239|Firmicutes,24N24@186801|Clostridia,42G72@68295|Thermoanaerobacterales	186801|Clostridia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
EH3_k127_6711460_2	525909.Afer_1597	8.662e-103	360.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4CMVQ@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
EH3_k127_6711460_1	635013.TherJR_0131	2.93e-120	404.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,2609P@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
EH3_k127_6711460_5	1121472.AQWN01000007_gene1167	1.877e-43	178.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,261HE@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
EH3_k127_6711460_3	1313172.YM304_33050	5.846e-61	221.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CN5A@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
EH3_k127_6711460_8	1410634.JHVD01000003_gene1935	2.068e-14	82.0	COG0797@1|root,COG3583@1|root,COG0797@2|Bacteria,COG3583@2|Bacteria,2IRQI@201174|Actinobacteria,4DWKR@85009|Propionibacteriales	201174|Actinobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642,ko:K21688	-	-	-	-	ko00000	-	-	-	DPBB_1,DUF348,G5
EH3_k127_6732232_4	1047013.AQSP01000099_gene1508	1.225e-19	95.0	COG4907@1|root,COG4907@2|Bacteria,2NR5D@2323|unclassified Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
EH3_k127_6732232_3	1386089.N865_05505	1.66e-25	108.0	2EJUD@1|root,33DJ1@2|Bacteria,2I7T2@201174|Actinobacteria	201174|Actinobacteria	S	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
EH3_k127_6732232_2	56107.Cylst_1736	3.711e-75	271.0	COG0076@1|root,COG0076@2|Bacteria,1G3F8@1117|Cyanobacteria,1HP30@1161|Nostocales	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86	ko:K01580,ko:K01593,ko:K13745	ko00250,ko00260,ko00350,ko00360,ko00380,ko00410,ko00430,ko00650,ko00901,ko00950,ko00965,ko01100,ko01110,ko01120,ko02024,ko04726,ko04727,ko04728,ko04940,ko05030,ko05031,ko05034,map00250,map00260,map00350,map00360,map00380,map00410,map00430,map00650,map00901,map00950,map00965,map01100,map01110,map01120,map02024,map04726,map04727,map04728,map04940,map05030,map05031,map05034	M00027,M00037,M00042	R00261,R00489,R00685,R00699,R00736,R01682,R02080,R02466,R02701,R04909,R07650	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
EH3_k127_6732232_5	1504319.GM45_0125	9.277e-06	57.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,3UWRY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_6732232_0	479433.Caci_5942	1.551e-109	362.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
EH3_k127_6732232_1	1122182.KB903833_gene5401	1.717e-99	359.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
EH3_k127_6736015_2	1150864.MILUP08_41028	1.435e-133	436.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DAJR@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
EH3_k127_6736015_1	469371.Tbis_0917	1.8e-138	451.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DYM7@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
EH3_k127_6736015_4	479434.Sthe_0599	1.466e-19	96.0	COG2318@1|root,COG2318@2|Bacteria,2G98Y@200795|Chloroflexi,27YQK@189775|Thermomicrobia	189775|Thermomicrobia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
EH3_k127_6736015_0	266940.Krad_1135	7.139e-175	567.0	COG0465@1|root,COG0465@2|Bacteria,2I9X7@201174|Actinobacteria	201174|Actinobacteria	O	Belongs to the AAA ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
EH3_k127_6736015_3	1283299.AUKG01000001_gene1898	7.418e-39	156.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4CQ97@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
EH3_k127_6743776_1	1121468.AUBR01000003_gene627	7.875e-113	376.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,42FQT@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
EH3_k127_6743776_5	1137271.AZUM01000001_gene602	8.279e-49	181.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4E019@85010|Pseudonocardiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
EH3_k127_6743776_6	1382306.JNIM01000001_gene3883	8.939e-42	168.0	COG1490@1|root,COG1490@2|Bacteria,2G6P5@200795|Chloroflexi	200795|Chloroflexi	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
EH3_k127_6743776_0	266940.Krad_3048	5.169e-259	818.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
EH3_k127_6743776_3	471852.Tcur_2115	9.712e-68	234.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4EIYA@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
EH3_k127_6743776_4	477641.MODMU_3354	1.467e-63	243.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4ERCU@85013|Frankiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
EH3_k127_6743776_2	1122138.AQUZ01000011_gene4987	3.371e-69	245.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4DP94@85009|Propionibacteriales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
EH3_k127_6801055_7	1169154.KB897778_gene3421	3.034e-73	252.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
EH3_k127_6801055_4	351607.Acel_0758	1.154e-111	378.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4ES3D@85013|Frankiales	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
EH3_k127_6801055_12	1148.1653447	1.414e-27	122.0	COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1H5QB@1142|Synechocystis	1117|Cyanobacteria	J	Ribosomal L27 protein	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
EH3_k127_6801055_13	1120948.KB903247_gene4479	3.4e-19	102.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4E4K1@85010|Pseudonocardiales	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
EH3_k127_6801055_2	644283.Micau_4889	5.674e-141	477.0	COG1530@1|root,COG3170@1|root,COG1530@2|Bacteria,COG3170@2|Bacteria,2GMM5@201174|Actinobacteria,4DAJS@85008|Micromonosporales	201174|Actinobacteria	J	Ribonuclease E/G family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
EH3_k127_6801055_11	284031.JNXD01000005_gene3580	1.626e-28	129.0	COG2197@1|root,COG2197@2|Bacteria,2GNAU@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
EH3_k127_6801055_6	471852.Tcur_1543	1.064e-94	330.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4EFT6@85012|Streptosporangiales	201174|Actinobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
EH3_k127_6801055_3	471852.Tcur_1542	5.533e-112	386.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4EHIA@85012|Streptosporangiales	201174|Actinobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	FTSW_RODA_SPOVE,PBP_dimer,Transpeptidase
EH3_k127_6801055_15	1298880.AUEV01000003_gene3536	4.471e-11	70.0	COG2891@1|root,COG2891@2|Bacteria,2GN0I@201174|Actinobacteria	201174|Actinobacteria	M	rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
EH3_k127_6801055_10	47716.JOFH01000020_gene2859	4.784e-42	165.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria	201174|Actinobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
EH3_k127_6801055_0	656024.FsymDg_1524	1.7e-163	521.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4ES3S@85013|Frankiales	201174|Actinobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
EH3_k127_6801055_9	1096546.WYO_0719	7.052e-56	207.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,1JTKC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
EH3_k127_6801055_5	555088.DealDRAFT_1964	4.428e-95	333.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42JKV@68298|Syntrophomonadaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
EH3_k127_6801055_8	1280688.AUJB01000016_gene1566	1.36e-61	230.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3NGR4@46205|Pseudobutyrivibrio	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH3_k127_6801055_14	1313172.YM304_21310	3.541e-17	84.0	COG0236@1|root,COG0236@2|Bacteria,2HGA0@201174|Actinobacteria,4CN8U@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
EH3_k127_6801055_1	858215.Thexy_1358	5.733e-142	463.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,42FCV@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
EH3_k127_6803659_6	926560.KE387023_gene3345	2.538e-31	124.0	COG1803@1|root,COG1803@2|Bacteria,1WJTD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
EH3_k127_6803659_5	1385519.N801_01520	3.923e-41	165.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4FGFA@85021|Intrasporangiaceae	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
EH3_k127_6803659_0	518766.Rmar_2539	3.966e-177	560.0	COG1180@1|root,COG1180@2|Bacteria,4NJ18@976|Bacteroidetes	976|Bacteroidetes	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
EH3_k127_6803659_4	526225.Gobs_2556	9.715e-60	235.0	COG1355@1|root,COG1355@2|Bacteria	2|Bacteria	C	regulation of microtubule-based process	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
EH3_k127_6803659_2	748280.NH8B_1552	7.656e-89	306.0	COG2040@1|root,COG2040@2|Bacteria,1QTE6@1224|Proteobacteria,2VNST@28216|Betaproteobacteria,2KTUC@206351|Neisseriales	206351|Neisseriales	H	Homocysteine S-methyltransferase	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
EH3_k127_6803659_1	316274.Haur_4305	1.551e-92	316.0	COG0820@1|root,COG0820@2|Bacteria,2G5SD@200795|Chloroflexi,374VF@32061|Chloroflexia	32061|Chloroflexia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
EH3_k127_6803659_3	1185876.BN8_06700	4.082e-68	239.0	COG2085@1|root,COG2085@2|Bacteria,4NEC7@976|Bacteroidetes,47QUG@768503|Cytophagia	976|Bacteroidetes	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
EH3_k127_6815088_1	1163408.UU9_08852	1.399e-76	267.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,1RXZF@1236|Gammaproteobacteria,1X3IK@135614|Xanthomonadales	135614|Xanthomonadales	CQ	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_3,Cytochrome_CBB3
EH3_k127_6815088_4	525909.Afer_1452	3.291e-33	134.0	COG1959@1|root,COG1959@2|Bacteria,2GS0E@201174|Actinobacteria,4CNRF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
EH3_k127_6815088_3	266117.Rxyl_2982	5.536e-41	170.0	COG5002@1|root,COG5002@2|Bacteria,2I3V4@201174|Actinobacteria,4CR2M@84995|Rubrobacteria	84995|Rubrobacteria	T	PFAM ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like PAS fold-4	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
EH3_k127_6815088_7	246194.CHY_0161	7.303e-05	52.0	29Y0M@1|root,30JTI@2|Bacteria,1V50V@1239|Firmicutes,24GAX@186801|Clostridia,42G5J@68295|Thermoanaerobacterales	186801|Clostridia	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
EH3_k127_6815088_2	246194.CHY_1283	3.244e-55	210.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,42FR9@68295|Thermoanaerobacterales	186801|Clostridia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
EH3_k127_6815088_5	1485543.JMME01000003_gene2019	1.545e-20	105.0	COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,4H4PK@909932|Negativicutes	909932|Negativicutes	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
EH3_k127_6815088_6	1089553.Tph_c00400	3.151e-15	89.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,42GQS@68295|Thermoanaerobacterales	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
EH3_k127_6815088_0	469371.Tbis_0072	4.362e-96	331.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4DXI3@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
EH3_k127_6909584_7	509190.Cseg_0271	0.0002845	44.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,2UJHW@28211|Alphaproteobacteria,2KJ5I@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
EH3_k127_6909584_4	1169144.KB910942_gene2627	3.223e-14	81.0	COG1514@1|root,COG1514@2|Bacteria,1VBG1@1239|Firmicutes,4IMER@91061|Bacilli,1ZJZC@1386|Bacillus	91061|Bacilli	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
EH3_k127_6909584_0	246196.MSMEI_0647	2.917e-216	686.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae	201174|Actinobacteria	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
EH3_k127_6909584_2	1380390.JIAT01000013_gene64	4.467e-52	193.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4CQ9B@84995|Rubrobacteria	84995|Rubrobacteria	K	Uncharacterized ACR, COG1678	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
EH3_k127_6909584_3	326427.Cagg_3130	1.573e-24	107.0	COG0500@1|root,COG2226@2|Bacteria,2G948@200795|Chloroflexi,376TJ@32061|Chloroflexia	32061|Chloroflexia	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH3_k127_6909584_5	1449357.JQLK01000001_gene295	1.548e-08	62.0	COG0500@1|root,COG2226@2|Bacteria,1WJAK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH3_k127_6909584_1	656024.FsymDg_3753	1.87e-121	398.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4EX6N@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
EH3_k127_6909584_6	121225.PHUM390660-PA	6.56e-08	61.0	COG0308@1|root,KOG1046@2759|Eukaryota,38CFG@33154|Opisthokonta,3BADC@33208|Metazoa,3CW5S@33213|Bilateria,41WW7@6656|Arthropoda,3SGEA@50557|Insecta,3E9UH@33342|Paraneoptera	33208|Metazoa	E	ERAP1-like C-terminal domain	NPEPPS	GO:0000003,GO:0000209,GO:0000578,GO:0000793,GO:0000922,GO:0001666,GO:0003002,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0006950,GO:0007049,GO:0007275,GO:0007350,GO:0007351,GO:0007389,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008595,GO:0009056,GO:0009628,GO:0009790,GO:0009792,GO:0009798,GO:0009880,GO:0009948,GO:0009952,GO:0009987,GO:0010564,GO:0010720,GO:0015630,GO:0016567,GO:0016787,GO:0019538,GO:0022402,GO:0022414,GO:0030588,GO:0030590,GO:0032446,GO:0032501,GO:0032502,GO:0033218,GO:0033554,GO:0034641,GO:0035282,GO:0036211,GO:0036293,GO:0036294,GO:0042221,GO:0042277,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043603,GO:0043900,GO:0043902,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0044770,GO:0044771,GO:0045595,GO:0045597,GO:0046662,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050896,GO:0051094,GO:0051179,GO:0051235,GO:0051239,GO:0051240,GO:0051321,GO:0051445,GO:0051640,GO:0051641,GO:0051642,GO:0051651,GO:0051657,GO:0051661,GO:0051716,GO:0051726,GO:0060281,GO:0060282,GO:0060284,GO:0061842,GO:0065007,GO:0065008,GO:0070006,GO:0070011,GO:0070482,GO:0070647,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0072686,GO:0097431,GO:0140096,GO:1900193,GO:1900195,GO:1901564,GO:1901565,GO:1901575,GO:1903046,GO:1903429,GO:1903431,GO:1903538,GO:1905879,GO:1905881,GO:1990947,GO:2000241,GO:2000243	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
EH3_k127_6917686_8	374847.Kcr_1119	5.079e-22	96.0	COG0374@1|root,arCOG01549@2157|Archaea	2157|Archaea	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	mvhA	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
EH3_k127_6917686_10	1206725.BAFU01000247_gene2554	8.271e-15	80.0	COG0680@1|root,COG0680@2|Bacteria,2IJ3P@201174|Actinobacteria,4G2NH@85025|Nocardiaceae	201174|Actinobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
EH3_k127_6917686_13	882.DVU_2328	9.281e-08	63.0	COG0375@1|root,COG0375@2|Bacteria,1PTY5@1224|Proteobacteria,42U07@68525|delta/epsilon subdivisions,2WPIB@28221|Deltaproteobacteria,2MCEE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
EH3_k127_6917686_5	1123508.JH636441_gene3745	1.788e-69	250.0	COG3172@1|root,COG3172@2|Bacteria	2|Bacteria	H	ATPase kinase involved in NAD metabolism	nadR	-	-	-	-	-	-	-	-	-	-	-	AAA_28,CTP_transf_like
EH3_k127_6917686_11	35754.JNYJ01000001_gene7340	1.788e-10	62.0	COG3201@1|root,COG3201@2|Bacteria,2GMBT@201174|Actinobacteria,4DD4M@85008|Micromonosporales	201174|Actinobacteria	H	Nicotinamide mononucleotide transporter	pnuC	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
EH3_k127_6917686_9	1304865.JAGF01000001_gene1006	3.788e-21	97.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
EH3_k127_6917686_7	684949.ATTJ01000001_gene1018	4.593e-36	141.0	COG4270@1|root,COG4270@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,DoxX_2
EH3_k127_6917686_6	525904.Tter_1200	4.254e-54	213.0	COG1331@1|root,COG1331@2|Bacteria,2NPT4@2323|unclassified Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	DUF4861
EH3_k127_6917686_2	1280390.CBQR020000069_gene1436	2.03e-90	327.0	COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,4HAUT@91061|Bacilli,275NJ@186822|Paenibacillaceae	91061|Bacilli	G	glycosidase	-	-	2.4.1.339,2.4.1.340	ko:K20885	-	-	R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
EH3_k127_6917686_3	697281.Mahau_2341	3.48e-88	320.0	COG0438@1|root,COG0438@2|Bacteria,1TQRQ@1239|Firmicutes,249H2@186801|Clostridia,42EVC@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
EH3_k127_6917686_4	452637.Oter_3708	1.67e-74	256.0	COG2227@1|root,COG2227@2|Bacteria,46VSV@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Protein of unknown function (DUF1698)	-	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	-
EH3_k127_6917686_1	251221.35212629	1.152e-151	491.0	COG0498@1|root,COG0498@2|Bacteria,1G0SV@1117|Cyanobacteria	1117|Cyanobacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_6917686_12	262724.TT_C1395	1.572e-08	58.0	COG1724@1|root,COG1724@2|Bacteria,1WKCX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
EH3_k127_6917686_14	289376.THEYE_A1078	9.347e-06	56.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
EH3_k127_6917686_0	1206737.BAGF01000023_gene1201	3.249e-157	506.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4FUF7@85025|Nocardiaceae	201174|Actinobacteria	E	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
EH3_k127_6949233_1	1304865.JAGF01000001_gene1818	1.198e-14	75.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria	201174|Actinobacteria	K	DNA binding domain, excisionase family	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
EH3_k127_6949233_0	1306174.JODP01000013_gene7517	1.983e-67	244.0	COG4972@1|root,COG4972@2|Bacteria,2IBNF@201174|Actinobacteria	201174|Actinobacteria	NU	pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
EH3_k127_6949233_2	1043493.BBLU01000001_gene842	4.01e-06	56.0	COG3166@1|root,COG3166@2|Bacteria,2GWQ0@201174|Actinobacteria	201174|Actinobacteria	NU	PFAM Fimbrial assembly family protein	-	-	-	-	-	-	-	-	-	-	-	-	PilN
EH3_k127_709687_2	443143.GM18_2209	1.05e-37	154.0	COG0840@1|root,COG3290@1|root,COG4251@1|root,COG0840@2|Bacteria,COG3290@2|Bacteria,COG4251@2|Bacteria,1MU9B@1224|Proteobacteria,42N1S@68525|delta/epsilon subdivisions,2WK7R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1
EH3_k127_709687_3	633131.TR2A62_0879	4.2e-12	76.0	2EE5F@1|root,33800@2|Bacteria,1R6R9@1224|Proteobacteria,2UST4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_709687_4	1123321.KB905815_gene3388	1.088e-05	51.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria	201174|Actinobacteria	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
EH3_k127_709687_1	1043205.AFYF01000006_gene1475	1.34e-53	195.0	COG0300@1|root,COG0300@2|Bacteria,2HJGE@201174|Actinobacteria,4FGMX@85021|Intrasporangiaceae	201174|Actinobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
EH3_k127_709687_0	710111.FraQA3DRAFT_6201	1.456e-55	210.0	COG3361@1|root,COG3361@2|Bacteria,2I6N0@201174|Actinobacteria,4EVEC@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
EH3_k127_7099927_12	196162.Noca_1630	2.554e-54	192.0	COG2141@1|root,COG2141@2|Bacteria,2GNQ3@201174|Actinobacteria,4DT50@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
EH3_k127_7099927_9	1343740.M271_13710	4.223e-87	302.0	COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
EH3_k127_7099927_11	1463825.JNXC01000015_gene7587	1.02e-61	220.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4E2JM@85010|Pseudonocardiales	201174|Actinobacteria	C	[2Fe-2S] binding domain	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
EH3_k127_7099927_3	330084.JNYZ01000020_gene4751	3.661e-162	528.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4DZHW@85010|Pseudonocardiales	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
EH3_k127_7099927_0	266117.Rxyl_2839	5.834e-286	902.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CPP1@84995|Rubrobacteria	84995|Rubrobacteria	C	xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
EH3_k127_7099927_6	511051.CSE_04680	9.745e-116	391.0	COG0078@1|root,COG0078@2|Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
EH3_k127_7099927_14	1382306.JNIM01000001_gene2679	9.924e-10	64.0	COG3255@1|root,COG3255@2|Bacteria,2G7E8@200795|Chloroflexi	200795|Chloroflexi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH3_k127_7099927_13	338966.Ppro_1137	2.58e-16	93.0	COG2050@1|root,COG2050@2|Bacteria,1PP3U@1224|Proteobacteria,43E7M@68525|delta/epsilon subdivisions,2X2FF@28221|Deltaproteobacteria,43V5X@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Thioesterase-like superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
EH3_k127_7099927_5	926569.ANT_27910	1.041e-123	427.0	COG1079@1|root,COG1079@2|Bacteria,2G6BT@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
EH3_k127_7099927_8	356851.JOAN01000001_gene3736	4.778e-93	323.0	COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4D9JU@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
EH3_k127_7099927_1	935839.JAGJ01000010_gene374	4.586e-201	638.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4F44H@85017|Promicromonosporaceae	201174|Actinobacteria	S	ATPases associated with a variety of cellular activities	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
EH3_k127_7099927_7	446469.Sked_25760	3.182e-112	374.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria	201174|Actinobacteria	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
EH3_k127_7099927_10	379066.GAU_3928	6.572e-64	226.0	COG0035@1|root,COG0035@2|Bacteria,1ZT1C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
EH3_k127_7099927_4	1298863.AUEP01000002_gene1504	4.487e-132	430.0	COG2876@1|root,COG2876@2|Bacteria,2I3UA@201174|Actinobacteria,4DQ2H@85009|Propionibacteriales	201174|Actinobacteria	E	DAHP synthetase I family	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
EH3_k127_7099927_2	1122138.AQUZ01000019_gene8174	8.601e-190	614.0	COG0737@1|root,COG1524@1|root,COG3379@1|root,COG0737@2|Bacteria,COG1524@2|Bacteria,COG3379@2|Bacteria,2HFJ5@201174|Actinobacteria,4DVDK@85009|Propionibacteriales	201174|Actinobacteria	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C
EH3_k127_712127_3	2074.JNYD01000038_gene532	8.596e-17	93.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4DX6K@85010|Pseudonocardiales	201174|Actinobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
EH3_k127_712127_1	1370125.AUWT01000032_gene1633	1.193e-61	226.0	COG2203@1|root,COG2203@2|Bacteria,2I97I@201174|Actinobacteria	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
EH3_k127_712127_0	1370125.AUWT01000032_gene1634	2.452e-112	370.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
EH3_k127_712127_2	316274.Haur_0049	4.123e-41	171.0	COG0664@1|root,COG0664@2|Bacteria,2GAUQ@200795|Chloroflexi,377NH@32061|Chloroflexia	32061|Chloroflexia	K	Crp-like helix-turn-helix domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
EH3_k127_7155581_2	419947.MRA_2543	8.654e-09	65.0	2ENST@1|root,33GDY@2|Bacteria,2IK5I@201174|Actinobacteria,239KM@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7155581_0	1121877.JQKF01000011_gene381	2.849e-140	457.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CMX1@84992|Acidimicrobiia	84992|Acidimicrobiia	E	ACT domain	ask	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
EH3_k127_7155581_1	67352.JODS01000006_gene6632	2.323e-128	421.0	COG1506@1|root,COG1506@2|Bacteria,2GJ6A@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	pepX	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
EH3_k127_7161137_6	235985.BBPN01000040_gene354	1.658e-23	113.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,2NKRD@228398|Streptacidiphilus	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
EH3_k127_7161137_0	1242864.D187_004550	4.59e-225	706.0	COG1509@1|root,COG1509@2|Bacteria,1R8HT@1224|Proteobacteria,43DMX@68525|delta/epsilon subdivisions,2X6DS@28221|Deltaproteobacteria,2YUSV@29|Myxococcales	28221|Deltaproteobacteria	E	lysine 2,3-aminomutase	kamA1	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	LAM_C
EH3_k127_7161137_1	298654.FraEuI1c_2218	4.85e-211	672.0	COG0021@1|root,COG0021@2|Bacteria,2I36F@201174|Actinobacteria,4EX6G@85013|Frankiales	201174|Actinobacteria	H	Belongs to the transketolase family	tkt3	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
EH3_k127_7161137_4	710111.FraQA3DRAFT_5454	2.8e-55	201.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4EV3P@85013|Frankiales	201174|Actinobacteria	S	TIGRFAM channel protein, hemolysin III family	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
EH3_k127_7161137_2	469383.Cwoe_4727	3.725e-122	404.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4CRSZ@84995|Rubrobacteria	84995|Rubrobacteria	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
EH3_k127_7161137_9	1313172.YM304_30980	1.881e-05	53.0	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
EH3_k127_7161137_5	309801.trd_1386	3.412e-53	200.0	2DPD0@1|root,331J4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7161137_3	997346.HMPREF9374_0645	3.806e-112	374.0	COG1063@1|root,COG1063@2|Bacteria,1UI0K@1239|Firmicutes,4IUD0@91061|Bacilli,27D28@186824|Thermoactinomycetaceae	91061|Bacilli	C	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
EH3_k127_7161137_8	349741.Amuc_0362	7.958e-07	57.0	2ERYI@1|root,33JHP@2|Bacteria,46WPE@74201|Verrucomicrobia,2IUEZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7161137_7	1539298.JO41_05795	3.766e-13	71.0	COG0156@1|root,COG0156@2|Bacteria,2J615@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_7255778_5	404589.Anae109_2884	4.025e-09	60.0	COG1515@1|root,COG1515@2|Bacteria	2|Bacteria	L	deoxyribonuclease V activity	nfi	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
EH3_k127_7255778_1	309801.trd_1282	4.84e-75	261.0	COG1834@1|root,COG1834@2|Bacteria,2G7QT@200795|Chloroflexi,27YZU@189775|Thermomicrobia	189775|Thermomicrobia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
EH3_k127_7255778_7	1267535.KB906767_gene1010	2.172e-05	53.0	COG2606@1|root,COG2606@2|Bacteria,3Y4MI@57723|Acidobacteria,2JJ7H@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	-	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
EH3_k127_7255778_4	1386089.N865_21240	4.476e-19	99.0	2DU40@1|root,33NV5@2|Bacteria,2GTWE@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
EH3_k127_7255778_0	1123023.JIAI01000008_gene1476	4.787e-93	323.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria,4EA0B@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
EH3_k127_7255778_3	1120949.KB903314_gene344	4.361e-39	151.0	COG0778@1|root,COG0778@2|Bacteria,2HG9I@201174|Actinobacteria,4DK68@85008|Micromonosporales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH3_k127_7255778_2	1463921.JODF01000039_gene4952	9.621e-75	266.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
EH3_k127_7255778_6	29306.JOBE01000055_gene91	2.466e-06	59.0	COG1295@1|root,COG1295@2|Bacteria,2H11D@201174|Actinobacteria	201174|Actinobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
EH3_k127_7265856_1	1121430.JMLG01000013_gene1877	7.701e-95	318.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,26106@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
EH3_k127_7265856_0	1463825.JNXC01000022_gene530	2.213e-146	477.0	COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria,4DZMQ@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	1.2.1.18,1.2.1.27,2.6.1.19	ko:K00140,ko:K00823	ko00250,ko00280,ko00410,ko00562,ko00640,ko00650,ko01100,ko01120,ko01200,map00250,map00280,map00410,map00562,map00640,map00650,map01100,map01120,map01200	M00013,M00027	R00705,R00706,R00908,R00922,R00935,R01648	RC00004,RC00006,RC00062,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH3_k127_7265856_2	2002.JOEQ01000012_gene5630	5.024e-34	132.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4EKJP@85012|Streptosporangiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
EH3_k127_7309778_5	1216932.CM240_1942	4.802e-59	217.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,36ESG@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
EH3_k127_7309778_6	1229780.BN381_420028	1.967e-57	217.0	COG0642@1|root,COG0642@2|Bacteria,2HFQI@201174|Actinobacteria,3UXFY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA
EH3_k127_7309778_0	525904.Tter_2416	3.76e-135	437.0	COG0861@1|root,COG0861@2|Bacteria,2NNXY@2323|unclassified Bacteria	2|Bacteria	P	Integral membrane protein TerC family	alx	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
EH3_k127_7309778_7	590998.Celf_0802	4.193e-10	64.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
EH3_k127_7309778_2	298654.FraEuI1c_6494	2.653e-102	340.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yunF	-	-	-	-	-	-	-	-	-	-	-	DUF72
EH3_k127_7309778_1	1223523.H340_08646	4.545e-121	402.0	COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
EH3_k127_7309778_8	35754.JNYJ01000002_gene6949	0.0002671	55.0	COG1595@1|root,COG1595@2|Bacteria,2H5A8@201174|Actinobacteria,4DJ20@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
EH3_k127_7309778_3	1122611.KB903964_gene4962	2.141e-70	257.0	COG1408@1|root,COG1408@2|Bacteria,2GM8M@201174|Actinobacteria,4ER1A@85012|Streptosporangiales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
EH3_k127_7309778_4	28072.Nos7524_2763	2.411e-60	222.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1GC0N@1117|Cyanobacteria,1HR0M@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
EH3_k127_7320797_4	446470.Snas_5708	7.125e-28	117.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria,4EYPF@85014|Glycomycetales	201174|Actinobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
EH3_k127_7320797_1	710696.Intca_0186	4.709e-113	383.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FFQG@85021|Intrasporangiaceae	201174|Actinobacteria	P	Part of an ABC transporter complex. Responsible for energy coupling to the transport system	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
EH3_k127_7320797_2	1463920.JOGB01000004_gene4592	7.329e-86	297.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
EH3_k127_7320797_5	298653.Franean1_2135	2.493e-21	99.0	COG0310@1|root,COG0310@2|Bacteria,2GRUA@201174|Actinobacteria,4EWWX@85013|Frankiales	201174|Actinobacteria	P	PDGLE domain	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	PDGLE
EH3_k127_7320797_3	591159.ACEZ01000121_gene414	1.848e-67	243.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria	201174|Actinobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
EH3_k127_7320797_0	525909.Afer_1791	4.22e-124	405.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMUP@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
EH3_k127_7349202_0	1128421.JAGA01000002_gene1742	4.583e-186	599.0	COG1331@1|root,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
EH3_k127_7349202_2	292459.STH404	1.2e-69	247.0	COG0702@1|root,COG0702@2|Bacteria,1VEC8@1239|Firmicutes,25BCI@186801|Clostridia	186801|Clostridia	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
EH3_k127_7349202_3	68170.KL590535_gene3736	2.247e-41	159.0	COG3439@1|root,COG3439@2|Bacteria,2IKVF@201174|Actinobacteria,4E4ZR@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
EH3_k127_7349202_5	1120949.KB903295_gene2182	6.798e-14	72.0	COG0640@1|root,COG0640@2|Bacteria,2IR66@201174|Actinobacteria,4DFMJ@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
EH3_k127_7349202_4	644966.Tmar_1742	1.18e-23	109.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
EH3_k127_7349202_1	485913.Krac_2372	4.416e-92	316.0	2DBVK@1|root,2ZBBH@2|Bacteria,2G7SF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7383949_1	1463921.JODF01000029_gene3527	1.093e-73	258.0	COG2403@1|root,COG2403@2|Bacteria,2H3G5@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	-
EH3_k127_7383949_0	42256.RradSPS_1600	3.088e-88	306.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	CP_0969	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
EH3_k127_7383949_2	1089453.GOSPT_119_00240	1.077e-12	74.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,4GAEI@85026|Gordoniaceae	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
EH3_k127_7423532_3	1048834.TC41_1279	5.144e-81	278.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H9T4@91061|Bacilli,2785M@186823|Alicyclobacillaceae	91061|Bacilli	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
EH3_k127_7423532_11	63737.Npun_R6228	6.509e-25	108.0	COG0745@1|root,COG0745@2|Bacteria,1G11F@1117|Cyanobacteria,1HR4R@1161|Nostocales	1117|Cyanobacteria	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
EH3_k127_7423532_2	224324.aq_920	2.129e-82	285.0	COG0457@1|root,COG0552@1|root,COG0457@2|Bacteria,COG0552@2|Bacteria,2G3W2@200783|Aquificae	200783|Aquificae	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
EH3_k127_7423532_0	269800.Tfu_0655	1.557e-166	565.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4EFGD@85012|Streptosporangiales	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
EH3_k127_7423532_10	1348663.KCH_01570	3.212e-26	109.0	COG1254@1|root,COG1254@2|Bacteria,2I20A@201174|Actinobacteria,2M5UM@2063|Kitasatospora	201174|Actinobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
EH3_k127_7423532_5	106370.Francci3_1355	9.67e-63	226.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,4ET2V@85013|Frankiales	201174|Actinobacteria	Q	PFAM isochorismatase hydrolase	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
EH3_k127_7423532_6	696281.Desru_2500	4.076e-62	223.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,260YT@186807|Peptococcaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
EH3_k127_7423532_4	1246474.ANBE01000049_gene1390	1.074e-71	264.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4EGGX@85012|Streptosporangiales	201174|Actinobacteria	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
EH3_k127_7423532_13	1158318.ATXC01000001_gene18	8.089e-16	83.0	COG0333@1|root,COG0333@2|Bacteria,2G4C1@200783|Aquificae	200783|Aquificae	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
EH3_k127_7423532_9	1137268.AZXF01000010_gene2748	3.463e-28	122.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,4EJ56@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized ACR, COG1399	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
EH3_k127_7423532_12	1122939.ATUD01000004_gene3789	6.065e-22	108.0	COG0711@1|root,COG0711@2|Bacteria,2HNZ4@201174|Actinobacteria,4CQ8B@84995|Rubrobacteria	84995|Rubrobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7423532_7	351607.Acel_1578	2.329e-55	201.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4ESMC@85013|Frankiales	201174|Actinobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
EH3_k127_7423532_8	42256.RradSPS_1378	2.067e-36	151.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4CQ9U@84995|Rubrobacteria	84995|Rubrobacteria	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
EH3_k127_7423532_1	635013.TherJR_2099	8.649e-111	368.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,260I6@186807|Peptococcaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
EH3_k127_7475483_2	429009.Adeg_1759	6.274e-54	206.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42EWB@68295|Thermoanaerobacterales	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
EH3_k127_7475483_4	633147.Olsu_0164	2.472e-27	115.0	COG0736@1|root,COG0736@2|Bacteria,2HT7V@201174|Actinobacteria,4CVSA@84998|Coriobacteriia	84998|Coriobacteriia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
EH3_k127_7475483_0	1121272.KB903250_gene2948	2.086e-216	687.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4DA3Y@85008|Micromonosporales	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
EH3_k127_7475483_1	446468.Ndas_5160	1.047e-130	435.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4EGXD@85012|Streptosporangiales	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
EH3_k127_7475483_3	1123320.KB889640_gene4450	4.619e-30	129.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
EH3_k127_7484624_16	867903.ThesuDRAFT_01592	4.05e-05	53.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3WD23@538999|Clostridiales incertae sedis	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
EH3_k127_7484624_11	411470.RUMGNA_00339	1.059e-34	143.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3XZ3I@572511|Blautia	186801|Clostridia	M	Belongs to the peptidase S11 family	dacB2	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
EH3_k127_7484624_8	1079986.JH164852_gene338	2.951e-47	179.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria	201174|Actinobacteria	K	merR family	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
EH3_k127_7484624_7	469371.Tbis_1693	8.054e-48	177.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4E2ZJ@85010|Pseudonocardiales	201174|Actinobacteria	T	(FHA) domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
EH3_k127_7484624_10	543632.JOJL01000004_gene4308	1.238e-41	161.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4DE4E@85008|Micromonosporales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
EH3_k127_7484624_13	1121952.ATXT01000011_gene2607	1.742e-32	134.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4FNKM@85023|Microbacteriaceae	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
EH3_k127_7484624_1	1448389.BAVQ01000079_gene519	3.189e-114	386.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria	201174|Actinobacteria	F	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
EH3_k127_7484624_12	1229780.BN381_290068	3.945e-34	140.0	COG0204@1|root,COG0283@1|root,COG0204@2|Bacteria,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,3UWT7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Cytidylate kinase	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyltransferase,Cytidylate_kin
EH3_k127_7484624_3	644966.Tmar_0220	9.694e-89	309.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3WCSS@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
EH3_k127_7484624_6	264732.Moth_1333	6.254e-49	191.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,42GDJ@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
EH3_k127_7484624_14	1907.SGLAU_25435	1.784e-31	127.0	COG4401@1|root,COG4401@2|Bacteria,2IHWT@201174|Actinobacteria	201174|Actinobacteria	E	Chorismate mutase	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
EH3_k127_7484624_4	1120949.KB903312_gene568	6.813e-63	227.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4DBFH@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
EH3_k127_7484624_9	1229780.BN381_290071	5.206e-47	175.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,3UWQK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
EH3_k127_7484624_5	1120934.KB894435_gene4473	2.106e-50	190.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4DXFN@85010|Pseudonocardiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
EH3_k127_7484624_2	632292.Calhy_1895	5.286e-107	357.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,42EWC@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
EH3_k127_7484624_15	633147.Olsu_0911	1.387e-30	132.0	COG1994@1|root,COG1994@2|Bacteria,2GM8E@201174|Actinobacteria,4CUK0@84998|Coriobacteriia	84998|Coriobacteriia	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
EH3_k127_7484624_0	401526.TcarDRAFT_0503	9.435e-118	393.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,4H20A@909932|Negativicutes	909932|Negativicutes	F	pyrimidine-nucleoside phosphorylase	pyn	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
EH3_k127_7591308_7	266117.Rxyl_1657	9.888e-36	142.0	COG2403@1|root,COG2403@2|Bacteria,2H3G5@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	-
EH3_k127_7591308_4	1463921.JODF01000029_gene3526	2.442e-62	227.0	COG2074@1|root,COG2074@2|Bacteria,2H6N5@201174|Actinobacteria	201174|Actinobacteria	G	phosphotransferase activity, carboxyl group as acceptor	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	-
EH3_k127_7591308_3	1552123.EP57_02465	8.884e-68	252.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,4HA8G@91061|Bacilli,26K04@186820|Listeriaceae	91061|Bacilli	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU37110	TAL_FSA
EH3_k127_7591308_0	1288083.AUKR01000002_gene4563	5.849e-149	489.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
EH3_k127_7591308_8	525909.Afer_1810	2.061e-33	130.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
EH3_k127_7591308_2	883156.HMPREF9282_00028	1.347e-83	290.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,4H271@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
EH3_k127_7591308_10	269800.Tfu_2396	0.0005238	51.0	COG2268@1|root,COG2268@2|Bacteria,2GKTJ@201174|Actinobacteria,4EHSF@85012|Streptosporangiales	201174|Actinobacteria	S	DivIVA protein	abpS	-	-	-	-	-	-	-	-	-	-	-	DivIVA
EH3_k127_7591308_1	264732.Moth_2397	5.504e-116	392.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
EH3_k127_7591308_5	526225.Gobs_4147	5.122e-52	194.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4ESEI@85013|Frankiales	201174|Actinobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
EH3_k127_7591308_6	1996.JOFO01000071_gene2198	2.038e-43	166.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4EIA3@85012|Streptosporangiales	201174|Actinobacteria	J	Belongs to the SUA5 family	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
EH3_k127_7591308_9	1123257.AUFV01000012_gene2947	8.39e-06	48.0	COG0394@1|root,COG0394@2|Bacteria,1N0DZ@1224|Proteobacteria,1S92S@1236|Gammaproteobacteria,1X7TK@135614|Xanthomonadales	135614|Xanthomonadales	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
EH3_k127_760790_6	68199.JNZO01000023_gene1882	3.662e-09	60.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type spermidine putrescine transport system, permease component I	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_760790_2	479432.Sros_1882	2.791e-87	307.0	COG0687@1|root,COG0687@2|Bacteria,2GKVG@201174|Actinobacteria,4EGYS@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
EH3_k127_760790_1	1417296.U879_09205	6.553e-137	445.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	ydcT	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
EH3_k127_760790_3	1146883.BLASA_3926	2.509e-77	274.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4ERX0@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 4	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
EH3_k127_760790_0	370438.PTH_2824	7.536e-140	460.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,2609R@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
EH3_k127_760790_4	525909.Afer_1196	1.724e-50	188.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4CN5Y@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Ribose/Galactose Isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
EH3_k127_760790_5	370438.PTH_2826	9.402e-14	77.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,262N5@186807|Peptococcaceae	186801|Clostridia	T	Low molecular weight phosphotyrosine protein phosphatase	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
EH3_k127_7608916_4	1229780.BN381_30048	4.912e-24	104.0	COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria	201174|Actinobacteria	P	phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	HSP70,PBP_like,PBP_like_2
EH3_k127_7608916_1	1313172.YM304_07700	1.242e-80	278.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
EH3_k127_7608916_2	1313172.YM304_07710	3.755e-75	263.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria	201174|Actinobacteria	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
EH3_k127_7608916_0	1245475.ANAE01000206_gene3943	6.842e-120	391.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EM3I@85012|Streptosporangiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
EH3_k127_7608916_3	1380390.JIAT01000001_gene4997	1.011e-36	155.0	COG0704@1|root,COG0704@2|Bacteria,2HGEG@201174|Actinobacteria,4CPTJ@84995|Rubrobacteria	84995|Rubrobacteria	P	Plays a role in the regulation of phosphate uptake	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
EH3_k127_7673452_1	1035308.AQYY01000001_gene2473	3.747e-27	125.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,260F2@186807|Peptococcaceae	186801|Clostridia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C,UvrD_C_2
EH3_k127_7673452_0	749414.SBI_04046	1.686e-145	493.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
EH3_k127_7673576_8	981369.JQMJ01000004_gene452	2.089e-13	71.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,2NIHT@228398|Streptacidiphilus	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
EH3_k127_7673576_9	32264.tetur18g03370.1	2.273e-10	69.0	COG1371@1|root,KOG4528@2759|Eukaryota,39U2I@33154|Opisthokonta,3BD8T@33208|Metazoa,3CWE8@33213|Bilateria,41ZNF@6656|Arthropoda	33208|Metazoa	S	Archease protein family (MTH1598/TM1083)	ZBTB8OS	GO:0000394,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0007275,GO:0007399,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0010720,GO:0010975,GO:0010976,GO:0016070,GO:0022008,GO:0030154,GO:0031344,GO:0031346,GO:0031974,GO:0031981,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0048679,GO:0048680,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051128,GO:0051130,GO:0051239,GO:0051240,GO:0051960,GO:0051962,GO:0060284,GO:0065007,GO:0070013,GO:0070570,GO:0070572,GO:0071704,GO:0072669,GO:0080134,GO:0080135,GO:0090304,GO:0120035,GO:1901360,GO:1903034,GO:1903036,GO:2000026	-	-	-	-	-	-	-	-	-	-	Archease
EH3_k127_7673576_0	1125863.JAFN01000001_gene3570	2.664e-161	524.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
EH3_k127_7673576_6	300852.55772730	3.309e-29	125.0	COG0204@1|root,COG0204@2|Bacteria,1WJXG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
EH3_k127_7673576_2	1896.JOAU01000026_gene3337	1.541e-96	340.0	COG0624@1|root,COG0624@2|Bacteria,2GMH2@201174|Actinobacteria	201174|Actinobacteria	E	peptidase	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
EH3_k127_7673576_4	404589.Anae109_1660	1.017e-68	236.0	COG1839@1|root,COG1839@2|Bacteria,1RBCB@1224|Proteobacteria,42S44@68525|delta/epsilon subdivisions,2WMAS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
EH3_k127_7673576_1	469371.Tbis_2198	4.545e-112	369.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DY7I@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
EH3_k127_7673576_5	58123.JOFJ01000006_gene298	1.717e-30	121.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4EH24@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
EH3_k127_7673576_3	1449355.JQNR01000003_gene794	4.814e-73	267.0	COG2971@1|root,COG2971@2|Bacteria,2GKNB@201174|Actinobacteria	201174|Actinobacteria	G	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
EH3_k127_7673576_10	67332.FM21_06750	4.417e-06	56.0	COG0726@1|root,COG0726@2|Bacteria,2HEQK@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	xynD	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	CBM_2,Polysacc_deac_1
EH3_k127_7673576_7	1410653.JHVC01000007_gene600	3.244e-14	86.0	COG0726@1|root,COG0726@2|Bacteria,1UZGG@1239|Firmicutes,249C9@186801|Clostridia,36FFF@31979|Clostridiaceae	186801|Clostridia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Polysacc_deac_1
EH3_k127_774062_13	1386089.N865_20090	5.422e-23	108.0	COG3408@1|root,COG3408@2|Bacteria,2GIUI@201174|Actinobacteria,4FFC5@85021|Intrasporangiaceae	201174|Actinobacteria	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
EH3_k127_774062_12	219305.MCAG_01657	1.735e-25	113.0	COG3255@1|root,COG3255@2|Bacteria,2GTJZ@201174|Actinobacteria,4DJ9B@85008|Micromonosporales	201174|Actinobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
EH3_k127_774062_17	1380356.JNIK01000003_gene1177	3.915e-09	64.0	COG4803@1|root,COG4803@2|Bacteria,2IQV0@201174|Actinobacteria,4EWI7@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
EH3_k127_774062_4	675635.Psed_2045	2.098e-95	320.0	COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4E6Z6@85010|Pseudonocardiales	201174|Actinobacteria	G	Major intrinsic protein	-	-	-	ko:K02440,ko:K06188,ko:K09874	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.12,1.A.8.2	-	-	MIP
EH3_k127_774062_21	402777.KB235904_gene4456	0.0005777	48.0	28N7T@1|root,2ZBCE@2|Bacteria,1G50K@1117|Cyanobacteria,1H966@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_774062_19	1283283.ATXA01000008_gene3170	1.669e-07	55.0	2E61I@1|root,3176Z@2|Bacteria,2HCFB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_774062_0	67352.JODS01000031_gene799	0.0	1069.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
EH3_k127_774062_2	1150398.JIBJ01000005_gene3177	5.929e-116	383.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria	201174|Actinobacteria	G	polyphosphate kinase	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
EH3_k127_774062_18	797209.ZOD2009_13221	1.331e-07	55.0	arCOG02806@1|root,arCOG02806@2157|Archaea,2XVAW@28890|Euryarchaeota,23Z3N@183963|Halobacteria	183963|Halobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
EH3_k127_774062_10	479431.Namu_2957	1.99e-30	126.0	2CK3K@1|root,32SBH@2|Bacteria,2IQJH@201174|Actinobacteria,4EW1Y@85013|Frankiales	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
EH3_k127_774062_15	675635.Psed_1136	2.976e-11	66.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4EA5D@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
EH3_k127_774062_20	391038.Bphy_2396	1.772e-06	52.0	COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,2VN9A@28216|Betaproteobacteria,1K2DQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
EH3_k127_774062_22	1205680.CAKO01000025_gene4612	0.0005938	46.0	COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,2TU46@28211|Alphaproteobacteria,2JUVN@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
EH3_k127_774062_16	1206101.AZXC01000009_gene527	1.022e-09	68.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
EH3_k127_774062_1	1380354.JIAN01000008_gene3481	1.473e-205	652.0	COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria,4F29I@85016|Cellulomonadaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
EH3_k127_774062_9	543632.JOJL01000070_gene3177	5.179e-55	203.0	2B189@1|root,31TNP@2|Bacteria,2GSQX@201174|Actinobacteria,4DKUX@85008|Micromonosporales	201174|Actinobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
EH3_k127_774062_7	1122182.KB903836_gene4748	5.342e-66	235.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria,4DAFF@85008|Micromonosporales	201174|Actinobacteria	L	5'-3' exonuclease	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
EH3_k127_774062_5	1198452.Jab_2c34270	1.665e-85	290.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4779T@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH3_k127_774062_6	189753.AXAS01000056_gene5966	1.581e-76	264.0	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2TVJW@28211|Alphaproteobacteria,3JXVQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.304,1.1.1.76	ko:K00059,ko:K18009	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671	RC00029,RC00117,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
EH3_k127_774062_8	1223523.H340_22326	1.66e-64	233.0	COG2357@1|root,COG2357@2|Bacteria,2I30R@201174|Actinobacteria	201174|Actinobacteria	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_774062_3	485913.Krac_10080	5.206e-107	353.0	COG0154@1|root,COG0154@2|Bacteria,2G7KI@200795|Chloroflexi	200795|Chloroflexi	J	PFAM Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
EH3_k127_7743451_12	91464.S7335_774	4.291e-05	52.0	COG0589@1|root,COG0589@2|Bacteria,1G6JK@1117|Cyanobacteria,1H1YU@1129|Synechococcus	1117|Cyanobacteria	T	T COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
EH3_k127_7743451_8	1449347.JQLN01000007_gene1817	2.018e-51	204.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria,2M4FI@2063|Kitasatospora	201174|Actinobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
EH3_k127_7743451_3	1394178.AWOO02000059_gene598	1.213e-104	361.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4EGQJ@85012|Streptosporangiales	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3,PAS_4
EH3_k127_7743451_10	861299.J421_1919	7.839e-39	147.0	COG2132@1|root,COG2132@2|Bacteria,1ZTWH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
EH3_k127_7743451_7	1128421.JAGA01000001_gene2386	2.122e-53	201.0	COG2132@1|root,COG2132@2|Bacteria,2NPD2@2323|unclassified Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,DUF4396
EH3_k127_7743451_11	351607.Acel_0515	3.45e-12	75.0	2BM3X@1|root,33KY1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7743451_6	285535.JOEY01000027_gene9518	1.529e-64	229.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
EH3_k127_7743451_0	595460.RRSWK_03757	0.0	1431.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
EH3_k127_7743451_9	595460.RRSWK_03757	1.723e-43	163.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
EH3_k127_7743451_1	595460.RRSWK_03756	1.534e-117	395.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
EH3_k127_7743451_4	1487921.DP68_09700	3.865e-76	276.0	COG3288@1|root,COG3288@2|Bacteria,1UP6K@1239|Firmicutes,25H78@186801|Clostridia,36GD7@31979|Clostridiaceae	186801|Clostridia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
EH3_k127_7743451_5	1511.CLOST_0512	4.906e-76	268.0	COG0686@1|root,COG0686@2|Bacteria,1UHWP@1239|Firmicutes,24FNG@186801|Clostridia	186801|Clostridia	E	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
EH3_k127_7743451_2	867903.ThesuDRAFT_01180	5.561e-108	354.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
EH3_k127_7766160_2	760568.Desku_0652	1.947e-18	88.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
EH3_k127_7766160_0	1229780.BN381_290106	1.997e-127	444.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,3UW69@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
EH3_k127_7766160_1	477974.Daud_1368	1.657e-114	384.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,2601M@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
EH3_k127_7768231_0	1410624.JNKK01000007_gene1809	1.384e-174	559.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,27I5X@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
EH3_k127_7768231_1	645465.ACUR01000350_gene5114	3.979e-53	201.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
EH3_k127_7768231_2	366394.Smed_3316	2.964e-48	188.0	COG0404@1|root,COG3665@1|root,COG0404@2|Bacteria,COG3665@2|Bacteria,1R3WG@1224|Proteobacteria,2TVX2@28211|Alphaproteobacteria,4BA6D@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
EH3_k127_7768231_3	1120973.AQXL01000105_gene2561	1.241e-29	130.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,27A2H@186823|Alicyclobacillaceae	91061|Bacilli	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
EH3_k127_7819279_2	373903.Hore_14240	9.288e-66	232.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3WAHE@53433|Halanaerobiales	186801|Clostridia	D	TIGRFAM cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
EH3_k127_7819279_3	222534.KB893670_gene3663	1.161e-51	197.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4ESJM@85013|Frankiales	201174|Actinobacteria	T	Belongs to the peptidase S16 family	lon	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
EH3_k127_7819279_1	671143.DAMO_1249	5.118e-207	677.0	COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
EH3_k127_7819279_0	1125863.JAFN01000001_gene2057	1.228e-215	686.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42P0M@68525|delta/epsilon subdivisions,2WJMC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
EH3_k127_7819279_4	1089545.KB913037_gene7153	1.288e-29	123.0	COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4DXK3@85010|Pseudonocardiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
EH3_k127_7841937_1	1120949.KB903306_gene7394	2.414e-14	75.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4DBP6@85008|Micromonosporales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
EH3_k127_7841937_0	485913.Krac_5903	1.014e-106	366.0	COG0210@1|root,COG0210@2|Bacteria,2GA78@200795|Chloroflexi	200795|Chloroflexi	L	PFAM NERD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NERD
EH3_k127_7841937_2	644966.Tmar_0200	2.15e-13	79.0	29Y0M@1|root,30JTI@2|Bacteria,1VEVD@1239|Firmicutes,24QVV@186801|Clostridia,3WDJ2@538999|Clostridiales incertae sedis	186801|Clostridia	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
EH3_k127_7841937_3	287.DR97_3569	0.0002677	46.0	COG0834@1|root,COG2202@1|root,COG3852@1|root,COG4585@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG3852@2|Bacteria,COG4585@2|Bacteria,1R6KY@1224|Proteobacteria,1S485@1236|Gammaproteobacteria,1YE3M@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
EH3_k127_7851378_5	525904.Tter_1871	4.046e-05	47.0	COG4867@1|root,COG4867@2|Bacteria,2NQZ8@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
EH3_k127_7851378_1	251221.35211202	4.256e-99	340.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria	1117|Cyanobacteria	P	Arylsulfatase a	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
EH3_k127_7851378_0	471852.Tcur_1054	1.58e-176	571.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4EGIC@85012|Streptosporangiales	201174|Actinobacteria	H	Sigma-54 interaction domain	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
EH3_k127_7851378_4	700508.D174_16670	4.83e-54	211.0	COG1177@1|root,COG1177@2|Bacteria,2ISUW@201174|Actinobacteria,23AV2@1762|Mycobacteriaceae	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053,ko:K11070	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_7851378_3	999549.KI421513_gene759	2.311e-56	208.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,280QZ@191028|Leisingera	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_7851378_2	700508.D174_16660	3.116e-57	216.0	COG0687@1|root,COG0687@2|Bacteria,2HQAG@201174|Actinobacteria,236G3@1762|Mycobacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
EH3_k127_7861751_5	1194165.CAJF01000023_gene3158	1.89e-38	147.0	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria	201174|Actinobacteria	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
EH3_k127_7861751_0	42256.RradSPS_0363	2.886e-114	376.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4CRP7@84995|Rubrobacteria	84995|Rubrobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N_2
EH3_k127_7861751_3	479434.Sthe_1008	2.52e-45	176.0	COG0454@1|root,COG0456@2|Bacteria,2G6N6@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH3_k127_7861751_2	452652.KSE_64370	3.473e-56	214.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,2M36W@2063|Kitasatospora	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
EH3_k127_7861751_4	908340.HMPREF9406_0042	3.254e-40	169.0	COG4990@1|root,COG4990@2|Bacteria,1TV6G@1239|Firmicutes,24C6X@186801|Clostridia,36M7H@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4872)	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
EH3_k127_7861751_1	1157637.KB892097_gene1122	6.911e-96	325.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
EH3_k127_7862187_10	370438.PTH_1245	7.727e-64	232.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,260T7@186807|Peptococcaceae	186801|Clostridia	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
EH3_k127_7862187_11	1172188.KB911821_gene1397	2.472e-63	229.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4FE45@85021|Intrasporangiaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
EH3_k127_7862187_5	351607.Acel_1546	9.231e-95	332.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4ERYG@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	whiG	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
EH3_k127_7862187_19	1136417.AZWE01000004_gene4376	1.454e-22	108.0	COG0739@1|root,COG0739@2|Bacteria,2IQ64@201174|Actinobacteria,4DEE2@85008|Micromonosporales	201174|Actinobacteria	M	peptidase M23B	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
EH3_k127_7862187_20	1123256.KB907926_gene1022	4.331e-13	82.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1X43X@135614|Xanthomonadales	135614|Xanthomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
EH3_k127_7862187_4	1089548.KI783301_gene681	8.365e-95	320.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,4H9N5@91061|Bacilli,3WDY5@539002|Bacillales incertae sedis	91061|Bacilli	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
EH3_k127_7862187_9	868595.Desca_1513	4.762e-71	245.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,260PI@186807|Peptococcaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
EH3_k127_7862187_6	656024.FsymDg_3660	9.655e-88	296.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4ERFG@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH3_k127_7862187_13	351607.Acel_1539	3.227e-58	211.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4ESC9@85013|Frankiales	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
EH3_k127_7862187_16	935839.JAGJ01000007_gene3109	8.91e-33	145.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4F425@85017|Promicromonosporaceae	201174|Actinobacteria	S	Cytidylyltransferase family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
EH3_k127_7862187_3	298653.Franean1_1168	7.545e-114	390.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4ERMJ@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2870c	DXPR_C,DXP_redisom_C,DXP_reductoisom
EH3_k127_7862187_14	656024.FsymDg_3654	5.335e-56	211.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4ESD0@85013|Frankiales	201174|Actinobacteria	M	PFAM peptidase M50	rip1	GO:0008150,GO:0040007	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
EH3_k127_7862187_8	1110697.NCAST_32_01010	3.768e-71	248.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4FVQ8@85025|Nocardiaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	cseB	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
EH3_k127_7862187_7	426716.JOAJ01000001_gene480	2.711e-81	284.0	COG0642@1|root,COG2205@2|Bacteria,2I2QY@201174|Actinobacteria,4FXB6@85025|Nocardiaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4173,HAMP,HATPase_c,HisKA
EH3_k127_7862187_18	1151117.AJLF01000001_gene1313	6.885e-26	113.0	COG0432@1|root,arCOG04214@2157|Archaea,2XXSW@28890|Euryarchaeota,2449A@183968|Thermococci	183968|Thermococci	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
EH3_k127_7862187_1	290402.Cbei_1197	2.49e-124	410.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,36DRW@31979|Clostridiaceae	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
EH3_k127_7862187_12	867903.ThesuDRAFT_01413	2.099e-61	218.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,3WDBJ@538999|Clostridiales incertae sedis	186801|Clostridia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
EH3_k127_7862187_2	1906.SFRA_31660	5.433e-117	396.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria	201174|Actinobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
EH3_k127_7862187_0	1125863.JAFN01000001_gene105	4.186e-165	544.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
EH3_k127_7862187_15	429009.Adeg_1666	7.516e-33	136.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,42GU2@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
EH3_k127_7862187_17	1229780.BN381_330069	1.782e-26	121.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,3UW9A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
EH3_k127_7915675_1	529709.PYCH_07920	1.025e-89	306.0	COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota,243F1@183968|Thermococci	183968|Thermococci	E	Belongs to the carbamate kinase family	cpkA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH3_k127_7915675_0	555079.Toce_2001	2.824e-175	560.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
EH3_k127_7985782_1	1380390.JIAT01000013_gene145	9.204e-83	282.0	COG0457@1|root,COG2114@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
EH3_k127_7985782_2	1380370.JIBA01000012_gene3541	5.433e-21	98.0	2EHZA@1|root,33BQS@2|Bacteria,2IJZ0@201174|Actinobacteria,4FGP6@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7985782_0	1382306.JNIM01000001_gene274	9.334e-177	569.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G6X3@200795|Chloroflexi	200795|Chloroflexi	H	NAD synthase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
EH3_k127_798584_5	324602.Caur_3337	1.169e-39	155.0	COG1816@1|root,COG1816@2|Bacteria,2G6AT@200795|Chloroflexi,374T6@32061|Chloroflexia	200795|Chloroflexi	F	PFAM adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
EH3_k127_798584_4	1254432.SCE1572_13050	1.354e-94	335.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
EH3_k127_798584_2	1121406.JAEX01000007_gene2379	3.768e-131	429.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,42NHC@68525|delta/epsilon subdivisions,2WJQJ@28221|Deltaproteobacteria,2MGAK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Alanine dehydrogenase/PNT, N-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
EH3_k127_798584_6	298654.FraEuI1c_5769	1.699e-30	124.0	COG3288@1|root,COG3288@2|Bacteria,2IKR9@201174|Actinobacteria	201174|Actinobacteria	C	NADP transhydrogenase	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
EH3_k127_798584_1	298655.KI912266_gene6493	5.574e-179	572.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4ERWF@85013|Frankiales	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
EH3_k127_798584_0	1192034.CAP_5178	2.371e-193	620.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
EH3_k127_798584_3	526227.Mesil_2410	9.191e-97	321.0	COG0001@1|root,COG0001@2|Bacteria,1WM90@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH3_k127_8052356_5	337191.KTR9_1848	1.76e-19	90.0	COG0440@1|root,COG0460@1|root,COG0440@2|Bacteria,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4GBVN@85026|Gordoniaceae	201174|Actinobacteria	E	Homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
EH3_k127_8052356_1	561175.KB894093_gene2955	2.204e-147	473.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4EGAS@85012|Streptosporangiales	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_8052356_3	469371.Tbis_0885	4.309e-52	206.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4DZTR@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
EH3_k127_8052356_0	986075.CathTA2_0500	1.355e-194	631.0	COG3408@1|root,COG3408@2|Bacteria,1TPX8@1239|Firmicutes,4HDVV@91061|Bacilli	91061|Bacilli	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
EH3_k127_8052356_4	479432.Sros_8763	2.415e-21	105.0	COG1376@1|root,COG1376@2|Bacteria,2INDP@201174|Actinobacteria,4EIQY@85012|Streptosporangiales	201174|Actinobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
EH3_k127_8052356_2	525909.Afer_1990	1.297e-67	243.0	COG0265@1|root,COG1286@1|root,COG0265@2|Bacteria,COG1286@2|Bacteria,2GJ92@201174|Actinobacteria,4CNDB@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
EH3_k127_8135900_3	1394178.AWOO02000042_gene8750	6.772e-68	234.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4EH4E@85012|Streptosporangiales	201174|Actinobacteria	C	4Fe-4S dicluster domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
EH3_k127_8135900_5	649638.Trad_1491	4.789e-17	92.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1WM3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_4,PAS_8
EH3_k127_8135900_4	1348663.KCH_39940	8.082e-44	169.0	COG2197@1|root,COG2197@2|Bacteria,2I8S4@201174|Actinobacteria,2M0I1@2063|Kitasatospora	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
EH3_k127_8135900_2	1292020.H483_0117005	1.427e-76	265.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
EH3_k127_8135900_0	1380393.JHVP01000003_gene1059	2.438e-108	360.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4ES7M@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
EH3_k127_8135900_1	1077972.ARGLB_037_00790	5.482e-101	342.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,2ITEV@201174|Actinobacteria,1WBN4@1268|Micrococcaceae	201174|Actinobacteria	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,rve,rve_3
EH3_k127_8292425_4	1158050.KB895455_gene1724	1.414e-32	132.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria	201174|Actinobacteria	M	phospholipase C	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
EH3_k127_8292425_0	867903.ThesuDRAFT_01181	2.039e-213	677.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,3WD6G@538999|Clostridiales incertae sedis	186801|Clostridia	CE	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
EH3_k127_8292425_3	479434.Sthe_1348	3.476e-40	158.0	COG0235@1|root,COG0235@2|Bacteria,2G9E9@200795|Chloroflexi,27YQX@189775|Thermomicrobia	189775|Thermomicrobia	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
EH3_k127_8292425_2	1157637.KB892091_gene5564	3.485e-66	244.0	COG0477@1|root,COG2814@2|Bacteria,2GJPT@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
EH3_k127_8292425_1	68219.JNXI01000002_gene3945	3.635e-78	281.0	COG1085@1|root,COG1085@2|Bacteria,2I2DM@201174|Actinobacteria	201174|Actinobacteria	C	galactose-1-phosphate uridylyltransferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
EH3_k127_8292425_5	401526.TcarDRAFT_2422	1.988e-25	108.0	COG4905@1|root,COG4905@2|Bacteria,1VAQJ@1239|Firmicutes,4H4VE@909932|Negativicutes	909932|Negativicutes	S	Putative ABC-transporter type IV	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
EH3_k127_8293946_0	311424.DhcVS_941	2.348e-190	611.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi,34CUT@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
EH3_k127_8293946_9	1289387.AUKW01000023_gene3030	5.309e-17	83.0	2BTN3@1|root,32NUZ@2|Bacteria,2GTXR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8293946_7	909613.UO65_2118	4.615e-43	172.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4DXD7@85010|Pseudonocardiales	201174|Actinobacteria	KT	Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
EH3_k127_8293946_6	1122182.KB903833_gene5482	1.637e-53	201.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4D8WJ@85008|Micromonosporales	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
EH3_k127_8293946_4	1158338.JNLJ01000001_gene956	1.765e-61	225.0	COG0175@1|root,COG0175@2|Bacteria,2G4VI@200783|Aquificae	200783|Aquificae	EH	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
EH3_k127_8293946_1	388467.A19Y_3950	8.601e-151	488.0	COG2046@1|root,COG2046@2|Bacteria,1G0E8@1117|Cyanobacteria,1H7XJ@1150|Oscillatoriales	1117|Cyanobacteria	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
EH3_k127_8293946_8	1313172.YM304_31100	4.784e-29	130.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	LysM,Peptidase_M23
EH3_k127_8293946_10	105425.BBPL01000010_gene2197	2.62e-08	63.0	2DP8R@1|root,32UKH@2|Bacteria,2IFBP@201174|Actinobacteria,2NINC@228398|Streptacidiphilus	201174|Actinobacteria	-	-	amfC	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8293946_5	1283299.AUKG01000003_gene232	9.52e-55	202.0	COG3437@1|root,COG3437@2|Bacteria,2I49F@201174|Actinobacteria,4CSEB@84995|Rubrobacteria	84995|Rubrobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
EH3_k127_8293946_2	287986.DV20_01930	2.08e-68	244.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4DYR1@85010|Pseudonocardiales	201174|Actinobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
EH3_k127_8293946_3	469371.Tbis_0494	6.199e-67	238.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4DX7I@85010|Pseudonocardiales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
EH3_k127_8297719_2	644283.Micau_4230	4.673e-21	102.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4D8TW@85008|Micromonosporales	201174|Actinobacteria	M	Transglycosylase	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
EH3_k127_8297719_1	309801.trd_1267	1.225e-42	175.0	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi,27XU8@189775|Thermomicrobia	189775|Thermomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
EH3_k127_8297719_3	2074.JNYD01000012_gene337	2.779e-20	93.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,4E4SU@85010|Pseudonocardiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
EH3_k127_8297719_0	1219035.NT2_05_00340	1.175e-42	162.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,2K4U7@204457|Sphingomonadales	204457|Sphingomonadales	J	endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
EH3_k127_8297719_4	1121364.ATVG01000002_gene1363	6.628e-17	90.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,22KS0@1653|Corynebacteriaceae	201174|Actinobacteria	J	Translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
EH3_k127_833179_0	1211815.CBYP010000041_gene2485	3.337e-208	666.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4ES5B@85013|Frankiales	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
EH3_k127_833179_6	309799.DICTH_0571	1.4e-21	106.0	COG2122@1|root,COG2122@2|Bacteria	2|Bacteria	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
EH3_k127_833179_2	243231.GSU2569	1.795e-91	316.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,43SZM@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
EH3_k127_833179_5	1229780.BN381_310071	5.407e-60	218.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,3UWNK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
EH3_k127_833179_3	479434.Sthe_2903	9.123e-81	279.0	COG2025@1|root,COG2025@2|Bacteria,2G6PP@200795|Chloroflexi,27XU4@189775|Thermomicrobia	189775|Thermomicrobia	C	Electron transfer flavoprotein	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
EH3_k127_833179_1	477641.MODMU_2852	7.445e-161	527.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4ERUR@85013|Frankiales	201174|Actinobacteria	EH	PFAM chorismate	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Chorismate_bind
EH3_k127_833179_7	68170.KL590470_gene11050	1.029e-06	57.0	COG0454@1|root,COG0456@2|Bacteria,2IPIF@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH3_k127_833179_4	479433.Caci_1281	7.393e-77	269.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
EH3_k127_833179_9	1397693.KK211187_gene2465	0.0007843	43.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,4HHF8@91061|Bacilli,3WFI7@539002|Bacillales incertae sedis	91061|Bacilli	P	Belongs to the Fur family	perR	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
EH3_k127_8346907_2	696281.Desru_0743	3.952e-79	269.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,260QV@186807|Peptococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
EH3_k127_8346907_7	1229780.BN381_130035	1.271e-34	139.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,3UWXZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	FR47-like protein	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
EH3_k127_8346907_4	1313172.YM304_08940	1.789e-48	189.0	COG1214@1|root,COG1214@2|Bacteria	2|Bacteria	O	tRNA threonylcarbamoyladenosine modification	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
EH3_k127_8346907_8	1347392.CCEZ01000007_gene2021	1.229e-30	129.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,36IUF@31979|Clostridiaceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
EH3_k127_8346907_3	330214.NIDE1518	3.707e-58	213.0	COG1573@1|root,COG1573@2|Bacteria,3J0MR@40117|Nitrospirae	40117|Nitrospirae	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
EH3_k127_8346907_1	1382306.JNIM01000001_gene771	4.538e-88	299.0	COG3191@1|root,COG3191@2|Bacteria,2G6BG@200795|Chloroflexi	200795|Chloroflexi	EQ	PFAM peptidase S58, DmpA	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
EH3_k127_8346907_6	1229203.KI301992_gene2056	4.465e-41	166.0	COG2267@1|root,COG2267@2|Bacteria,2HFQB@201174|Actinobacteria,3UXRJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8346907_0	1121468.AUBR01000001_gene578	6.902e-90	309.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
EH3_k127_8346907_5	1121422.AUMW01000010_gene1093	2.517e-44	168.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,260CR@186807|Peptococcaceae	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
EH3_k127_8351751_1	1231185.BAMP01000009_gene2222	2.385e-127	442.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,43JUX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
EH3_k127_8351751_2	1437448.AZRT01000127_gene264	7.151e-81	281.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,1J2P1@118882|Brucellaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
EH3_k127_8351751_3	868595.Desca_1311	2.352e-75	259.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
EH3_k127_8351751_4	1437448.AZRT01000127_gene266	9.133e-55	209.0	COG0683@1|root,COG0683@2|Bacteria,1MWYP@1224|Proteobacteria,2TTAM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
EH3_k127_8351751_5	304371.MCP_0999	9.691e-54	201.0	COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota,2N9TG@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH3_k127_8351751_6	1283283.ATXA01000008_gene3170	6.868e-52	188.0	2E61I@1|root,3176Z@2|Bacteria,2HCFB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8351751_0	43759.JNWK01000085_gene6817	1.404e-212	667.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	aslB	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
EH3_k127_8351751_7	67356.KL575591_gene1465	0.0006651	43.0	COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria	201174|Actinobacteria	K	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
EH3_k127_8401407_2	204669.Acid345_1271	7.539e-75	286.0	COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM phytoene desaturase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
EH3_k127_8401407_0	204669.Acid345_1270	1.07e-228	719.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
EH3_k127_8401407_1	1123073.KB899241_gene2287	2.021e-108	365.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales	135614|Xanthomonadales	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	GCV_T,GCV_T_C
EH3_k127_8401407_3	1210884.HG799463_gene9434	5.699e-14	85.0	COG1524@1|root,COG1524@2|Bacteria,2J1VF@203682|Planctomycetes	203682|Planctomycetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
EH3_k127_8404783_0	234267.Acid_5058	6.109e-112	374.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	-	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
EH3_k127_8404783_4	29306.JOBE01000008_gene4679	2.799e-06	53.0	COG0790@1|root,COG0790@2|Bacteria,2GKCE@201174|Actinobacteria	201174|Actinobacteria	KLT	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Sel1,TPR_10,TPR_16,TPR_4
EH3_k127_8404783_5	314265.R2601_19105	0.0002251	51.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
EH3_k127_8404783_2	1192034.CAP_8672	3.662e-17	87.0	COG2905@1|root,COG3202@1|root,COG2905@2|Bacteria,COG3202@2|Bacteria,1RERN@1224|Proteobacteria	1224|Proteobacteria	T	Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
EH3_k127_8404783_1	1131730.BAVI_07294	3.461e-45	175.0	COG2021@1|root,COG2021@2|Bacteria,1UN0R@1239|Firmicutes,4IUMT@91061|Bacilli,1ZSGR@1386|Bacillus	91061|Bacilli	E	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
EH3_k127_8404783_3	596151.DesfrDRAFT_3843	2.589e-06	59.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2M7T1@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
EH3_k127_8424342_4	40571.JOEA01000012_gene1068	3.369e-16	87.0	COG0730@1|root,COG0730@2|Bacteria,2IIY7@201174|Actinobacteria,4E3NW@85010|Pseudonocardiales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
EH3_k127_8424342_2	1123226.KB899277_gene1431	7.9e-51	200.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,4HE5R@91061|Bacilli,274YW@186822|Paenibacillaceae	91061|Bacilli	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
EH3_k127_8424342_1	298653.Franean1_1187	5.362e-79	275.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4ES77@85013|Frankiales	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
EH3_k127_8424342_0	1123023.JIAI01000002_gene5412	5.096e-121	404.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,4E1IY@85010|Pseudonocardiales	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
EH3_k127_8424342_3	266117.Rxyl_1415	2.999e-34	137.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CPY4@84995|Rubrobacteria	84995|Rubrobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_N
EH3_k127_8428029_3	1229203.KI301992_gene193	2.78e-51	206.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,3UWFY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
EH3_k127_8428029_0	1379698.RBG1_1C00001G1061	3.865e-156	514.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
EH3_k127_8428029_1	880072.Desac_2106	8.302e-148	489.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MS08@213462|Syntrophobacterales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
EH3_k127_8428029_7	106370.Francci3_0548	5.365e-28	126.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4ET3I@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
EH3_k127_8428029_6	298653.Franean1_6085	8.205e-41	166.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4ESIY@85013|Frankiales	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
EH3_k127_8428029_4	28042.GU90_05685	1.963e-49	188.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4DZ6U@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.5.3	ko:K00338,ko:K12143	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3153	Fer4
EH3_k127_8428029_2	1448389.BAVQ01000007_gene4217	2.616e-111	385.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	Fer4,NADHdh
EH3_k127_8428029_5	593907.Celgi_0742	2.149e-42	167.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4F0S5@85016|Cellulomonadaceae	201174|Actinobacteria	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
EH3_k127_845646_3	471857.Svir_35560	1.829e-07	55.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria,4DZM6@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
EH3_k127_845646_2	266117.Rxyl_2469	2.083e-74	263.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4CPNC@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
EH3_k127_845646_1	369723.Strop_4278	3.952e-78	275.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,4D9W0@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
EH3_k127_845646_0	502558.EGYY_07870	4.84e-106	356.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CUAX@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
EH3_k127_8522854_8	368407.Memar_2421	7.581e-21	104.0	COG2133@1|root,COG3794@1|root,arCOG02796@2157|Archaea,arCOG02929@2157|Archaea,2XT1Q@28890|Euryarchaeota	28890|Euryarchaeota	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,GSDH
EH3_k127_8522854_0	1380393.JHVP01000001_gene2412	3.756e-206	660.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4ERT0@85013|Frankiales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
EH3_k127_8522854_5	635013.TherJR_2719	2.779e-81	293.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,2616Z@186807|Peptococcaceae	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
EH3_k127_8522854_1	1237500.ANBA01000020_gene3251	1.548e-152	488.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4EFSC@85012|Streptosporangiales	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
EH3_k127_8522854_3	1121468.AUBR01000012_gene2582	1.944e-117	400.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
EH3_k127_8522854_4	1313172.YM304_21690	3.791e-94	323.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,4CMZ0@84992|Acidimicrobiia	84992|Acidimicrobiia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
EH3_k127_8522854_2	247490.KSU1_C0456	2.484e-122	405.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
EH3_k127_8522854_7	28444.JODQ01000007_gene5876	4.856e-28	131.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4EN96@85012|Streptosporangiales	201174|Actinobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH3_k127_8522854_6	1380390.JIAT01000009_gene1882	5.797e-32	138.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4CPDN@84995|Rubrobacteria	84995|Rubrobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
EH3_k127_8522854_9	1312959.KI914681_gene1998	8.118e-14	79.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,1W8EN@1268|Micrococcaceae	201174|Actinobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
EH3_k127_8522854_10	269800.Tfu_1821	6.771e-12	73.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4EIFK@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
EH3_k127_8523646_4	768704.Desmer_0448	6.778e-70	247.0	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia,260DN@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
EH3_k127_8523646_6	926550.CLDAP_19800	3.569e-47	194.0	28I8Y@1|root,2Z8BR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
EH3_k127_8523646_0	397278.JOJN01000002_gene635	7.723e-166	554.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,2HE4H@201174|Actinobacteria,4DTK0@85009|Propionibacteriales	201174|Actinobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
EH3_k127_8523646_2	1313172.YM304_35710	5.202e-83	295.0	COG1410@1|root,COG1410@2|Bacteria,2IC7C@201174|Actinobacteria	201174|Actinobacteria	E	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
EH3_k127_8523646_5	1089553.Tph_c27670	1.629e-49	192.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548,ko:K14084	ko00270,ko00450,ko00670,ko00680,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map01100,map01110,map01120,map01200,map01230	M00017,M00563	R00946,R09124,R09365	RC00035,RC00113,RC00732,RC01241,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
EH3_k127_8523646_1	1304874.JAFY01000002_gene574	1.882e-124	414.0	COG5598@1|root,COG5598@2|Bacteria,3TC8U@508458|Synergistetes	508458|Synergistetes	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
EH3_k127_8523646_3	1304874.JAFY01000002_gene574	2.568e-73	253.0	COG5598@1|root,COG5598@2|Bacteria,3TC8U@508458|Synergistetes	508458|Synergistetes	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
EH3_k127_8554233_2	1089553.Tph_c05460	7.121e-16	82.0	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,42H5Q@68295|Thermoanaerobacterales	186801|Clostridia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
EH3_k127_8554233_1	656024.FsymDg_4529	1.947e-23	106.0	2CQNK@1|root,32SMG@2|Bacteria,2IIJ7@201174|Actinobacteria,4ET55@85013|Frankiales	201174|Actinobacteria	S	Family of unknown function (DUF5318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5318
EH3_k127_8554233_0	266117.Rxyl_2308	3.851e-118	407.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CPUU@84995|Rubrobacteria	84995|Rubrobacteria	M	glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
EH3_k127_855468_1	1463861.JNXE01000011_gene1590	1.995e-21	106.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
EH3_k127_855468_0	521045.Kole_0725	6.018e-59	221.0	COG0635@1|root,COG0635@2|Bacteria,2GDT0@200918|Thermotogae	200918|Thermotogae	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH3_k127_855468_2	1121272.KB903252_gene1067	4.113e-07	61.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4DAD2@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
EH3_k127_8558433_1	867903.ThesuDRAFT_01770	1.317e-44	185.0	COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,248E0@186801|Clostridia	186801|Clostridia	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
EH3_k127_8558433_0	675635.Psed_3978	6.248e-238	757.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4E1QR@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
EH3_k127_8558433_2	1464048.JNZS01000010_gene5050	7.855e-07	62.0	COG5401@1|root,COG5401@2|Bacteria,2IK3M@201174|Actinobacteria,4DDDD@85008|Micromonosporales	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
EH3_k127_8573410_4	1380386.JIAW01000016_gene6340	6.946e-26	110.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,23EUD@1762|Mycobacteriaceae	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH3_k127_8573410_0	981369.JQMJ01000004_gene3842	5.842e-150	487.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,2NF51@228398|Streptacidiphilus	201174|Actinobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH3_k127_8573410_1	449447.MAE_61320	1.601e-128	416.0	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria	1117|Cyanobacteria	S	TIGRFAM polyphosphate nucleotide phosphotransferase, PPK2 family	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
EH3_k127_8573410_2	446470.Snas_2789	1.275e-81	286.0	COG3214@1|root,COG3214@2|Bacteria,2GP6G@201174|Actinobacteria	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
EH3_k127_8573410_3	126957.SMAR012664-PA	8.631e-27	111.0	COG0646@1|root,KOG1579@2759|Eukaryota,38H9Z@33154|Opisthokonta,3BF53@33208|Metazoa,3CSDJ@33213|Bilateria	33208|Metazoa	E	betaine-homocysteine S-methyltransferase activity	BHMT	GO:0000096,GO:0000097,GO:0001505,GO:0002064,GO:0002065,GO:0002066,GO:0002067,GO:0002068,GO:0003309,GO:0003323,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006521,GO:0006555,GO:0006575,GO:0006576,GO:0006577,GO:0006790,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009308,GO:0009310,GO:0009888,GO:0009987,GO:0010033,GO:0010243,GO:0010565,GO:0016053,GO:0016740,GO:0016741,GO:0017144,GO:0019222,GO:0019538,GO:0019695,GO:0019752,GO:0030154,GO:0030855,GO:0031016,GO:0031018,GO:0031323,GO:0031335,GO:0031982,GO:0032259,GO:0032501,GO:0032502,GO:0032991,GO:0033238,GO:0034641,GO:0035270,GO:0035883,GO:0036211,GO:0042133,GO:0042135,GO:0042221,GO:0042402,GO:0042426,GO:0042762,GO:0043094,GO:0043102,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043412,GO:0043414,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046394,GO:0046872,GO:0046914,GO:0047150,GO:0048468,GO:0048513,GO:0048731,GO:0048856,GO:0048869,GO:0050666,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0055123,GO:0060429,GO:0062012,GO:0065007,GO:0065008,GO:0070062,GO:0071265,GO:0071267,GO:0071704,GO:0080090,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1903561	2.1.1.10,2.1.1.5	ko:K00544,ko:K00547	ko00260,ko00270,ko01100,ko01110,map00260,map00270,map01100,map01110	-	R00650,R02821	RC00003,RC00035,RC00496	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
EH3_k127_858366_5	1304865.JAGF01000001_gene3493	8.47e-06	58.0	COG2132@1|root,COG2866@1|root,COG2132@2|Bacteria,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K22348,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,DUF4396
EH3_k127_858366_3	1089552.KI911559_gene1983	3.131e-30	131.0	COG0500@1|root,COG2226@2|Bacteria,1PHAK@1224|Proteobacteria,2V856@28211|Alphaproteobacteria,2JY4W@204441|Rhodospirillales	204441|Rhodospirillales	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH3_k127_858366_4	1173020.Cha6605_0233	1.315e-13	83.0	COG0517@1|root,COG0517@2|Bacteria,1G5TQ@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
EH3_k127_858366_0	469383.Cwoe_2559	1.935e-88	312.0	COG3191@1|root,COG3191@2|Bacteria,2H89D@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM peptidase S58, DmpA	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
EH3_k127_858366_1	247156.NFA_51700	1.109e-77	291.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4FUGW@85025|Nocardiaceae	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
EH3_k127_858366_2	1444309.JAQG01000075_gene140	6.191e-62	232.0	COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,4H9TV@91061|Bacilli,26RBP@186822|Paenibacillaceae	91061|Bacilli	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
EH3_k127_8651400_7	1288494.EBAPG3_8090	2.48e-65	229.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,2VY9I@28216|Betaproteobacteria,374Q8@32003|Nitrosomonadales	28216|Betaproteobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
EH3_k127_8651400_10	1463825.JNXC01000001_gene6348	1.14e-36	143.0	COG2009@1|root,COG2009@2|Bacteria,2IKU7@201174|Actinobacteria,4E3HK@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM succinate dehydrogenase, cytochrome b556 subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
EH3_k127_8651400_9	656024.FsymDg_0996	5.784e-37	148.0	COG2142@1|root,COG2142@2|Bacteria,2GNKE@201174|Actinobacteria,4EVBI@85013|Frankiales	201174|Actinobacteria	C	Succinate dehydrogenase hydrophobic	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
EH3_k127_8651400_0	525909.Afer_0312	6.107e-247	782.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4CN0E@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
EH3_k127_8651400_4	1463854.JOHT01000027_gene2458	8.405e-104	353.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria	201174|Actinobacteria	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
EH3_k127_8651400_8	1118054.CAGW01000056_gene2099	1.738e-63	223.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,4IQVA@91061|Bacilli	91061|Bacilli	C	COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
EH3_k127_8651400_5	648996.Theam_0603	1.915e-101	340.0	COG1951@1|root,COG1951@2|Bacteria,2G3JI@200783|Aquificae	200783|Aquificae	C	hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
EH3_k127_8651400_3	222534.KB893748_gene2766	1.726e-109	367.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4ESBM@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
EH3_k127_8651400_2	644966.Tmar_1299	7.254e-124	407.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,3WD3X@538999|Clostridiales incertae sedis	186801|Clostridia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
EH3_k127_8651400_11	67373.JOBF01000003_gene55	1.913e-17	89.0	2DUW4@1|root,32UXY@2|Bacteria,2IJWI@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4234)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4234
EH3_k127_8651400_6	522306.CAP2UW1_1830	2.21e-92	311.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1KPV1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
EH3_k127_8651400_1	196162.Noca_3583	3.206e-167	540.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4DP1R@85009|Propionibacteriales	201174|Actinobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
EH3_k127_8651400_13	1033730.CAHG01000002_gene2968	4.519e-05	48.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4DPAW@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
EH3_k127_8746135_0	1047013.AQSP01000134_gene1338	2.609e-76	265.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
EH3_k127_8746135_3	263358.VAB18032_14585	6.154e-16	88.0	2DIS7@1|root,30417@2|Bacteria,2HUR2@201174|Actinobacteria,4DFSW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8746135_1	1125971.ASJB01000083_gene1715	1.809e-27	120.0	COG0346@1|root,COG0346@2|Bacteria,2IM78@201174|Actinobacteria,4EBTP@85010|Pseudonocardiales	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8746135_2	1190606.AJYG01000096_gene3718	2.881e-21	109.0	COG2244@1|root,COG2244@2|Bacteria,1MWKV@1224|Proteobacteria,1S4AZ@1236|Gammaproteobacteria,1XWQF@135623|Vibrionales	135623|Vibrionales	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
EH3_k127_8752903_0	42256.RradSPS_3092	1.787e-155	512.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH3_k127_8752903_3	1304865.JAGF01000001_gene1568	1.21e-11	77.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
EH3_k127_8752903_1	1298863.AUEP01000019_gene3529	2.614e-104	350.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4DT5X@85009|Propionibacteriales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
EH3_k127_8752903_5	1464048.JNZS01000004_gene1682	1.584e-08	60.0	COG3620@1|root,COG3620@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K15773	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	CBS,HTH_3,HTH_31
EH3_k127_8752903_2	1379270.AUXF01000002_gene1393	2.407e-13	79.0	2DRPS@1|root,33CHR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
EH3_k127_8805468_1	408672.NBCG_02118	1.767e-170	549.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4DNDJ@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
EH3_k127_8805468_6	591158.SSMG_01400	1.748e-36	144.0	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria	201174|Actinobacteria	M	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
EH3_k127_8805468_2	1283299.AUKG01000001_gene2531	2.948e-166	538.0	COG0156@1|root,COG0156@2|Bacteria,2GISV@201174|Actinobacteria,4CP6E@84995|Rubrobacteria	201174|Actinobacteria	H	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
EH3_k127_8805468_4	345341.KUTG_04413	1.907e-61	230.0	COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4E10C@85010|Pseudonocardiales	201174|Actinobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9
EH3_k127_8805468_3	222534.KB893794_gene2479	8.945e-74	273.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4ERFW@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
EH3_k127_8805468_0	1068978.AMETH_1526	6.16e-208	664.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4DZ56@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
EH3_k127_8805468_5	471852.Tcur_3464	2.922e-40	171.0	COG1414@1|root,COG1414@2|Bacteria,2GKB0@201174|Actinobacteria,4EGUU@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix isocitrate lyase regulation	ltbR	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
EH3_k127_88296_2	1051006.HMPREF1162_0305	3.186e-25	111.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4DPQ2@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
EH3_k127_88296_3	1121877.JQKF01000004_gene1087	1.5e-07	58.0	2ERJT@1|root,33J59@2|Bacteria,2HGGQ@201174|Actinobacteria,4CNDW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
EH3_k127_88296_1	1122611.KB903978_gene3332	3.622e-113	388.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4EH2D@85012|Streptosporangiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
EH3_k127_88296_0	1146883.BLASA_2192	6.471e-283	900.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4ERJ2@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
EH3_k127_90748_8	479434.Sthe_2024	6.193e-15	77.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2G698@200795|Chloroflexi,27YAJ@189775|Thermomicrobia	189775|Thermomicrobia	E	Cysteine synthase	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_90748_7	292564.Cyagr_2042	7.81e-19	98.0	COG2410@1|root,COG2410@2|Bacteria,1GMRH@1117|Cyanobacteria,22TSM@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
EH3_k127_90748_0	58123.JOFJ01000004_gene1672	1.188e-138	467.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4EIFC@85012|Streptosporangiales	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
EH3_k127_90748_3	661478.OP10G_4211	2.262e-56	225.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
EH3_k127_90748_9	1448389.BAVQ01000036_gene831	3.57e-11	66.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
EH3_k127_90748_4	1340493.JNIF01000004_gene495	3.239e-41	162.0	COG1832@1|root,COG1832@2|Bacteria,3Y5TA@57723|Acidobacteria	57723|Acidobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
EH3_k127_90748_6	1443111.JASG01000004_gene3238	1.406e-23	116.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,3ZWKV@60136|Sulfitobacter	28211|Alphaproteobacteria	L	NUDIX domain	MA20_44635	-	-	-	-	-	-	-	-	-	-	-	NUDIX
EH3_k127_90748_1	867903.ThesuDRAFT_01514	6.553e-82	293.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,25CA8@186801|Clostridia,3WDHY@538999|Clostridiales incertae sedis	186801|Clostridia	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
EH3_k127_90748_2	1123024.AUII01000004_gene1463	1.031e-76	273.0	COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,4DYEF@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
EH3_k127_910780_1	266117.Rxyl_0583	6.172e-142	462.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,4CRM0@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
EH3_k127_910780_2	351607.Acel_1275	7.291e-94	319.0	COG2199@1|root,COG3706@2|Bacteria,2IABQ@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
EH3_k127_910780_0	479434.Sthe_2024	7.202e-162	520.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2G698@200795|Chloroflexi,27YAJ@189775|Thermomicrobia	189775|Thermomicrobia	E	Cysteine synthase	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_999634_4	326424.FRAAL6047	1.87e-23	110.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4ES9T@85013|Frankiales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
EH3_k127_999634_5	926569.ANT_10990	4.041e-17	87.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
EH3_k127_999634_3	1489678.RDMS_11280	1.727e-27	119.0	COG0664@1|root,COG0664@2|Bacteria,1WIWX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
EH3_k127_999634_1	1123023.JIAI01000002_gene5476	9.758e-78	271.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4DYTH@85010|Pseudonocardiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
EH3_k127_999634_2	1394178.AWOO02000087_gene929	3.398e-76	277.0	COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4EHR9@85012|Streptosporangiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	potI	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
EH3_k127_999634_0	58123.JOFJ01000003_gene2015	9.536e-93	312.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4EGH1@85012|Streptosporangiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	potH	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
## 1653 queries scanned
## Total time (seconds): 111.81870484352112
## Rate: 14.78 q/s