## Wed Oct 16 11:41:24 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/EH3_bin.37.fa -m mmseqs --itype genome -o EH3_bin.37 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/EH3_bin.37 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
EH3_k127_1101900_5	593750.Metfor_1881	3.412e-15	77.0	arCOG09272@1|root,arCOG09272@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1101900_2	456442.Mboo_0921	4.02e-109	362.0	COG1548@1|root,arCOG04369@2157|Archaea,2XVPP@28890|Euryarchaeota,2N9IT@224756|Methanomicrobia	224756|Methanomicrobia	K	Hydantoinase/oxoprolinase	-	-	2.5.1.131	ko:K07072	ko00680,map00680	-	R11040	RC01372,RC03335	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_A
EH3_k127_1101900_0	368407.Memar_1384	4.08e-127	412.0	COG1821@1|root,arCOG01592@2157|Archaea,2XXPE@28890|Euryarchaeota,2N9JU@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	6.3.4.24	ko:K06914	ko00680,map00680	-	R10902	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_3
EH3_k127_1101900_1	368407.Memar_1385	1.24e-124	403.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,2N9DM@224756|Methanomicrobia	224756|Methanomicrobia	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1192	SurE
EH3_k127_1101900_3	521011.Mpal_0583	1.121e-79	273.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
EH3_k127_1101900_4	593750.Metfor_1876	2.346e-42	157.0	COG4738@1|root,arCOG04377@2157|Archaea,2Y0VV@28890|Euryarchaeota,2N9YZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1110605_4	456442.Mboo_0007	4.297e-20	91.0	COG1270@1|root,arCOG04274@2157|Archaea,2XT37@28890|Euryarchaeota,2N9JD@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
EH3_k127_1110605_1	593750.Metfor_0171	1.391e-150	480.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,2N9DB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
EH3_k127_1110605_2	593750.Metfor_0170	2.28e-76	261.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,2N9HT@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
EH3_k127_1110605_0	323259.Mhun_0342	0.0	1151.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2NAFK@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
EH3_k127_1110605_3	593750.Metfor_0943	1.637e-72	248.0	COG0531@1|root,arCOG00009@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Trp_Tyr_perm,Usp
EH3_k127_1132366_11	323259.Mhun_2332	4.107e-84	280.0	COG0374@1|root,arCOG01549@2157|Archaea,2XSXP@28890|Euryarchaeota,2N964@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	frhA-1	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.98.1	ko:K00440	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
EH3_k127_1132366_3	456442.Mboo_0480	2.877e-166	527.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,2N944@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
EH3_k127_1132366_1	593750.Metfor_2711	2.345e-174	551.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,2N98K@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
EH3_k127_1132366_0	679926.Mpet_0587	1.363e-289	905.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,2N93B@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0536	AIRS,AIRS_C
EH3_k127_1132366_9	456442.Mboo_0483	4.956e-101	331.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,2N9JI@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
EH3_k127_1132366_13	521011.Mpal_2581	5.479e-33	132.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,2NA0Z@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
EH3_k127_1132366_10	593750.Metfor_2707	6.414e-97	324.0	COG1235@1|root,arCOG00499@2157|Archaea,2XTWY@28890|Euryarchaeota,2N9GT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM beta-lactamase domain protein	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
EH3_k127_1132366_2	593750.Metfor_2706	1.085e-173	554.0	COG0464@1|root,arCOG04368@2157|Archaea,2XT63@28890|Euryarchaeota,2N9B2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
EH3_k127_1132366_8	593750.Metfor_2705	9.175e-114	375.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
EH3_k127_1132366_6	593750.Metfor_2704	1.779e-122	404.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
EH3_k127_1132366_17	456442.Mboo_0489	1.699e-16	81.0	arCOG09499@1|root,arCOG09499@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1132366_15	456442.Mboo_0490	2.052e-31	125.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,2N9YC@224756|Methanomicrobia	224756|Methanomicrobia	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1132366_7	593750.Metfor_2699	1.691e-114	378.0	arCOG01220@1|root,arCOG01220@2157|Archaea,2XYGI@28890|Euryarchaeota,2N9S5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
EH3_k127_1132366_4	368407.Memar_2444	2.367e-143	460.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,2N9QE@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the LDH MDH superfamily	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
EH3_k127_1132366_14	521011.Mpal_2591	5.531e-32	126.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,2NA09@224756|Methanomicrobia	224756|Methanomicrobia	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
EH3_k127_1132366_16	593750.Metfor_2695	2.597e-24	102.0	COG2888@1|root,arCOG01989@2157|Archaea	2157|Archaea	J	Zn-ribbon RNA-binding protein with a function in translation	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
EH3_k127_1132366_12	456442.Mboo_0494	1.854e-53	199.0	COG2054@1|root,arCOG00859@2157|Archaea,2XVEI@28890|Euryarchaeota,2N9QG@224756|Methanomicrobia	224756|Methanomicrobia	S	aspartate glutamate uridylate kinase	-	-	2.7.4.31	ko:K07144	ko00680,map00680	-	R11039	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH3_k127_1132366_5	593750.Metfor_2693	2.167e-141	460.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
EH3_k127_1243868_1	368407.Memar_0702	2.129e-107	353.0	COG3635@1|root,arCOG01696@2157|Archaea,2XU1U@28890|Euryarchaeota,2N95W@224756|Methanomicrobia	224756|Methanomicrobia	G	phosphoglycerate mutase	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
EH3_k127_1243868_2	368407.Memar_0703	0.0001754	45.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2N966@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
EH3_k127_1243868_0	368407.Memar_0705	1.775e-125	415.0	COG4020@1|root,arCOG04885@2157|Archaea,2XV89@28890|Euryarchaeota,2N956@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0285 family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1296576_0	593750.Metfor_2049	1.521e-128	417.0	COG4294@1|root,arCOG01898@2157|Archaea,2XVT2@28890|Euryarchaeota	28890|Euryarchaeota	L	UV-endonuclease UvdE	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
EH3_k127_1296576_1	192952.MM_3293	4.472e-121	393.0	COG1600@1|root,arCOG02740@2157|Archaea,2Y47Z@28890|Euryarchaeota,2NAXR@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH3_k127_1296576_3	485913.Krac_5569	1.03e-12	73.0	COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
EH3_k127_1296576_2	679926.Mpet_2511	3.279e-45	166.0	COG2050@1|root,arCOG00777@2157|Archaea,2XXGC@28890|Euryarchaeota,2N9TQ@224756|Methanomicrobia	224756|Methanomicrobia	Q	Thioesterase superfamily	paaI	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
EH3_k127_1311910_1	593750.Metfor_2232	8.076e-189	592.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,2N9BE@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
EH3_k127_1311910_0	593750.Metfor_2231	3.801e-306	945.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
EH3_k127_1331408_3	521011.Mpal_2135	2.524e-60	213.0	arCOG05116@1|root,arCOG05116@2157|Archaea,2XX7X@28890|Euryarchaeota	28890|Euryarchaeota	J	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1331408_2	456442.Mboo_0940	1.729e-171	545.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,2NA2J@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
EH3_k127_1331408_0	456442.Mboo_0939	7.479e-247	788.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,2NA3F@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
EH3_k127_1331408_1	456442.Mboo_0937	4.234e-222	701.0	COG0433@1|root,arCOG00280@2157|Archaea,2XZQZ@28890|Euryarchaeota,2NB38@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
EH3_k127_1331408_4	368407.Memar_1615	2.525e-08	55.0	arCOG07472@1|root,arCOG07472@2157|Archaea	2157|Archaea	-	-	-	-	2.5.1.73	ko:K06868	ko00970,map00970	-	R08577	RC02948	ko00000,ko00001,ko01000,ko03016	-	-	-	-
EH3_k127_1352095_0	573413.Spirs_4212	1.238e-28	127.0	COG0242@1|root,COG0242@2|Bacteria	2|Bacteria	J	peptide deformylase activity	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	HTH_31,Pep_deformylase
EH3_k127_1387943_0	157072.XP_008869902.1	4.283e-07	63.0	COG5271@1|root,KOG1808@2759|Eukaryota	2759|Eukaryota	M	Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits	VWA8	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	AAA_5
EH3_k127_1435638_2	456442.Mboo_2138	3.599e-51	183.0	COG4992@1|root,arCOG00914@2157|Archaea,2XTKV@28890|Euryarchaeota,2N98X@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH3_k127_1435638_1	456442.Mboo_2139	1.257e-156	501.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,2N92B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
EH3_k127_1435638_0	593750.Metfor_0701	3.262e-272	844.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,2N94B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
EH3_k127_1435638_3	521011.Mpal_0071	3.106e-41	154.0	COG2050@1|root,arCOG00777@2157|Archaea,2Y26I@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
EH3_k127_1451593_3	368407.Memar_0274	8.396e-101	338.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2N9B3@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
EH3_k127_1451593_2	593750.Metfor_0293	1.137e-104	346.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,2N92A@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
EH3_k127_1451593_0	456442.Mboo_2391	3.132e-316	979.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
EH3_k127_1451593_1	593750.Metfor_0295	1.076e-182	580.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH3_k127_1452386_1	456442.Mboo_1924	1.313e-155	494.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
EH3_k127_1452386_0	456442.Mboo_1923	4.211e-304	942.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2N924@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM PilT protein domain protein	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
EH3_k127_1464279_0	593750.Metfor_2041	0.0	1031.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
EH3_k127_1464279_4	368407.Memar_1514	1.312e-32	130.0	COG5431@1|root,arCOG01121@2157|Archaea,2XY1I@28890|Euryarchaeota	28890|Euryarchaeota	S	zinc finger, SWIM	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
EH3_k127_1464279_2	456442.Mboo_1271	2.593e-79	271.0	COG0327@1|root,arCOG04454@2157|Archaea,2XT5G@28890|Euryarchaeota,2N9RT@224756|Methanomicrobia	224756|Methanomicrobia	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
EH3_k127_1464279_1	456442.Mboo_1272	6.039e-252	784.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
EH3_k127_1464279_3	593750.Metfor_2034	1.663e-50	184.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,2NA23@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
EH3_k127_1464279_5	593750.Metfor_1462	3.022e-20	92.0	COG4186@1|root,arCOG01154@2157|Archaea,2XYK6@28890|Euryarchaeota,2NAXE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
EH3_k127_153379_1	368407.Memar_1632	1.88e-186	590.0	COG1625@1|root,arCOG00950@2157|Archaea,2XTIR@28890|Euryarchaeota,2N94K@224756|Methanomicrobia	224756|Methanomicrobia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH3_k127_153379_5	368407.Memar_0430	6.069e-68	233.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,2N9S2@224756|Methanomicrobia	224756|Methanomicrobia	J	ribosomal protein S15	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
EH3_k127_153379_3	456442.Mboo_2236	1.116e-127	419.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
EH3_k127_153379_7	456442.Mboo_2237	2.307e-14	75.0	arCOG01354@1|root,arCOG01354@2157|Archaea,2Y224@28890|Euryarchaeota,2NA54@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_153379_0	521011.Mpal_2658	4.083e-245	765.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
EH3_k127_153379_4	593750.Metfor_0461	1.217e-83	281.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,2N9KM@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
EH3_k127_153379_2	368407.Memar_0425	1.322e-174	556.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,2NAHE@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
EH3_k127_153379_6	593750.Metfor_0457	4.761e-27	115.0	arCOG03479@1|root,arCOG03479@2157|Archaea,2Y0TG@28890|Euryarchaeota,2NB1D@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1534548_0	456442.Mboo_1927	1.363e-81	274.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
EH3_k127_1534548_3	521011.Mpal_0693	1.438e-39	153.0	COG1935@1|root,arCOG04420@2157|Archaea,2Y1FM@28890|Euryarchaeota,2NA37@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF473)	-	-	-	ko:K09135	-	-	-	-	ko00000	-	-	-	DUF473
EH3_k127_1534548_1	521011.Mpal_2164	3.614e-71	243.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2N9SC@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription termination protein NusA	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
EH3_k127_1534548_2	456442.Mboo_1930	1.914e-42	157.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,2NA2A@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein L7Ae L30e S12e Gadd45	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
EH3_k127_15464_4	593750.Metfor_0773	2.328e-14	78.0	COG2710@1|root,arCOG00593@2157|Archaea	2157|Archaea	C	PFAM oxidoreductase nitrogenase, component 1	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_nitro
EH3_k127_15464_2	410358.Mlab_0164	1.879e-72	257.0	COG2710@1|root,arCOG00598@2157|Archaea	2157|Archaea	C	PFAM oxidoreductase nitrogenase, component 1	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_nitro
EH3_k127_15464_0	593750.Metfor_0771	8.935e-129	416.0	COG1348@1|root,arCOG00590@2157|Archaea,2XUNI@28890|Euryarchaeota,2NBI4@224756|Methanomicrobia	224756|Methanomicrobia	D	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
EH3_k127_15464_1	593750.Metfor_0769	1.754e-100	337.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
EH3_k127_15464_3	593750.Metfor_1491	3.639e-33	136.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
EH3_k127_1579697_1	368407.Memar_0380	3.208e-110	370.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
EH3_k127_1579697_4	368407.Memar_2440	7.665e-89	301.0	COG0613@1|root,arCOG00302@2157|Archaea,2Y3KK@28890|Euryarchaeota	28890|Euryarchaeota	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
EH3_k127_1579697_0	368407.Memar_2038	1.239e-134	439.0	COG0388@1|root,arCOG00062@2157|Archaea,2XVVK@28890|Euryarchaeota,2NBG5@224756|Methanomicrobia	224756|Methanomicrobia	S	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase,PAD_porph
EH3_k127_1579697_2	368407.Memar_2038	3.398e-106	356.0	COG0388@1|root,arCOG00062@2157|Archaea,2XVVK@28890|Euryarchaeota,2NBG5@224756|Methanomicrobia	224756|Methanomicrobia	S	Porphyromonas-type peptidyl-arginine deiminase	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase,PAD_porph
EH3_k127_1579697_3	368407.Memar_0594	5.184e-96	323.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,2NAVM@224756|Methanomicrobia	224756|Methanomicrobia	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
EH3_k127_1579697_5	593750.Metfor_2050	7.068e-49	179.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota,2NB49@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM TspO MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
EH3_k127_1628375_4	228405.HNE_2611	0.0001454	46.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2UE8H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Uracil-DNA glycosylase superfamily	-	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
EH3_k127_1628375_2	679926.Mpet_2820	5.365e-25	105.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
EH3_k127_1628375_3	456442.Mboo_2175	1.421e-10	70.0	arCOG03888@1|root,arCOG03888@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_1628375_1	192952.MM_0232	4.089e-47	171.0	COG3324@1|root,arCOG04946@2157|Archaea,2Y3YR@28890|Euryarchaeota,2NB03@224756|Methanomicrobia	224756|Methanomicrobia	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
EH3_k127_1628375_0	368407.Memar_1442	2.819e-85	288.0	COG0655@1|root,arCOG02572@2157|Archaea,2Y8HP@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM NAD(P)H dehydrogenase (quinone)	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
EH3_k127_167745_1	456442.Mboo_0911	7.763e-49	175.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,2N9ZZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	tfs	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
EH3_k127_167745_0	456442.Mboo_0910	5.117e-92	310.0	COG4083@1|root,arCOG04471@2157|Archaea,2XTQZ@28890|Euryarchaeota,2N9VN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
EH3_k127_167745_2	380749.HY04AAS1_0066	4.29e-36	144.0	COG0558@1|root,COG0558@2|Bacteria,2G3Z1@200783|Aquificae	200783|Aquificae	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
EH3_k127_167745_3	456442.Mboo_0908	6.976e-16	79.0	COG1985@1|root,arCOG01484@2157|Archaea,2Y3FX@28890|Euryarchaeota,2NARM@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM bifunctional deaminase-reductase domain protein	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
EH3_k127_1682502_4	521011.Mpal_2730	3.387e-23	106.0	COG1473@1|root,arCOG01108@2157|Archaea,2XV81@28890|Euryarchaeota,2N9WP@224756|Methanomicrobia	224756|Methanomicrobia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
EH3_k127_1682502_2	580340.Tlie_0306	2.641e-112	370.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,3TCII@508458|Synergistetes	508458|Synergistetes	H	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH3_k127_1682502_3	368407.Memar_1507	4.033e-80	271.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,2N9QD@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM sugar isomerase (SIS)	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
EH3_k127_1682502_1	456442.Mboo_1200	9.681e-162	516.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9E9@224756|Methanomicrobia	224756|Methanomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_1682502_0	456442.Mboo_1201	3.319e-167	531.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,2N94F@224756|Methanomicrobia	224756|Methanomicrobia	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
EH3_k127_1736420_2	368407.Memar_0658	1.634e-24	104.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
EH3_k127_1736420_1	123214.PERMA_0044	1.913e-34	137.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	glsA	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	CBS,Glutaminase,MS_channel,STAS,cNMP_binding
EH3_k127_1736420_3	1207063.P24_03680	8.135e-10	66.0	COG4095@1|root,COG4095@2|Bacteria,1N759@1224|Proteobacteria,2UG31@28211|Alphaproteobacteria,2JTWT@204441|Rhodospirillales	204441|Rhodospirillales	S	Sugar efflux transporter for intercellular exchange	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	PQ-loop
EH3_k127_1736420_0	1187848.AJYQ01000142_gene2020	6.047e-40	161.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,1S1PQ@1236|Gammaproteobacteria,1XV2D@135623|Vibrionales	135623|Vibrionales	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH3_k127_1761981_2	593750.Metfor_0087	4.108e-121	400.0	COG0477@1|root,arCOG00147@2157|Archaea,2XTS8@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
EH3_k127_1761981_0	456442.Mboo_0066	0.0	1010.0	COG0365@1|root,arCOG04201@2157|Archaea,2Y84I@28890|Euryarchaeota,2NA7J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
EH3_k127_1761981_1	593750.Metfor_0084	1.051e-164	524.0	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,2N9EF@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
EH3_k127_2227072_2	368407.Memar_1088	1.081e-08	57.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,2NA1R@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
EH3_k127_2227072_0	368407.Memar_1087	2.614e-179	571.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,2N91D@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent	dadD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
EH3_k127_2227072_1	521011.Mpal_1036	2.011e-161	513.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
EH3_k127_2239425_4	679926.Mpet_0917	2.137e-28	118.0	COG0135@1|root,arCOG01983@2157|Archaea,2Y0F5@28890|Euryarchaeota,2NASD@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
EH3_k127_2239425_0	323259.Mhun_1790	5.762e-184	582.0	COG0133@1|root,arCOG01433@2157|Archaea,2XUHQ@28890|Euryarchaeota,2N9DF@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_2239425_2	323259.Mhun_1791	7.387e-77	267.0	COG0159@1|root,arCOG01086@2157|Archaea,2XTAW@28890|Euryarchaeota,2N9KY@224756|Methanomicrobia	224756|Methanomicrobia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
EH3_k127_2239425_3	456442.Mboo_0096	1.056e-75	260.0	arCOG01788@1|root,arCOG01788@2157|Archaea,2XXVU@28890|Euryarchaeota,2NAW7@224756|Methanomicrobia	224756|Methanomicrobia	Q	O-methyltransferase	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25
EH3_k127_2239425_1	1041930.Mtc_1121	1.882e-85	285.0	arCOG10401@1|root,arCOG10401@2157|Archaea,2Y2EP@28890|Euryarchaeota,2NA7M@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2262932_4	323259.Mhun_2613	5.26e-49	181.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
EH3_k127_2262932_3	456442.Mboo_2167	3.988e-75	258.0	COG0503@1|root,arCOG00030@2157|Archaea,2XTWM@28890|Euryarchaeota,2N9KI@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis	hpt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	iAF692.Mbar_A1633	Pribosyltran
EH3_k127_2262932_2	589924.Ferp_1624	9.153e-103	351.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,246M6@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the group II decarboxylase family. MfnA subfamily	mfnA	-	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
EH3_k127_2262932_0	593750.Metfor_0588	0.0	1150.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
EH3_k127_2262932_1	456442.Mboo_2164	7.177e-257	800.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
EH3_k127_2274904_1	593750.Metfor_2873	5.085e-132	425.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,2N9B7@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,RIO1
EH3_k127_2274904_10	456442.Mboo_0241	5.438e-20	91.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,2NA60@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
EH3_k127_2274904_6	593750.Metfor_2871	2.147e-33	131.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,2NA0E@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
EH3_k127_2274904_5	368407.Memar_2244	2.218e-50	183.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
EH3_k127_2274904_8	368407.Memar_2243	6.967e-26	109.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
EH3_k127_2274904_3	593750.Metfor_2868	1.144e-95	316.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,2N9GJ@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
EH3_k127_2274904_7	521011.Mpal_0604	1.915e-26	115.0	COG1412@1|root,arCOG04312@2157|Archaea,2XX55@28890|Euryarchaeota,2N9V2@224756|Methanomicrobia	224756|Methanomicrobia	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
EH3_k127_2274904_0	368407.Memar_2240	1.358e-213	668.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,2N93K@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
EH3_k127_2274904_4	521011.Mpal_0606	9.092e-73	246.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
EH3_k127_2274904_9	593750.Metfor_2865	3.117e-25	107.0	COG4014@1|root,arCOG04846@2157|Archaea	2157|Archaea	S	Uncharacterized protein conserved in archaea (DUF2098)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2098
EH3_k127_2274904_2	368407.Memar_2237	1.414e-107	354.0	COG1944@1|root,arCOG02882@2157|Archaea,2XUE0@28890|Euryarchaeota,2N9AP@224756|Methanomicrobia	224756|Methanomicrobia	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
EH3_k127_228662_3	269797.Mbar_A3616	4.057e-57	200.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,2N9X7@224756|Methanomicrobia	224756|Methanomicrobia	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
EH3_k127_228662_0	456442.Mboo_0263	0.0	1258.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,2N9FS@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
EH3_k127_228662_1	456442.Mboo_0264	5.998e-86	288.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,2N9K7@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
EH3_k127_228662_5	29078.XP_008160308.1	1.611e-34	136.0	COG0048@1|root,KOG1749@2759|Eukaryota,39ZWD@33154|Opisthokonta,3BPBM@33208|Metazoa,3CU4X@33213|Bilateria,488JW@7711|Chordata,4921H@7742|Vertebrata,3J51S@40674|Mammalia,4M2U7@9397|Chiroptera	33208|Metazoa	J	Ribosomal protein S23	RPS23	-	-	ko:K02973	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
EH3_k127_228662_4	521011.Mpal_0282	1.474e-55	201.0	COG0720@1|root,arCOG02172@2157|Archaea,2XX1X@28890|Euryarchaeota,2NBDZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM 6-pyruvoyl tetrahydropterin synthase and	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
EH3_k127_228662_2	593750.Metfor_2836	7.612e-83	280.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,2N9MX@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
EH3_k127_228662_6	593750.Metfor_2837	1.056e-25	109.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,2N9IW@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
EH3_k127_2340699_0	456442.Mboo_1105	3.668e-137	439.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
EH3_k127_2340699_2	456442.Mboo_1628	1.483e-52	190.0	arCOG05293@1|root,arCOG05293@2157|Archaea	2157|Archaea	G	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
EH3_k127_2340699_1	593750.Metfor_2573	1.139e-53	193.0	arCOG09584@1|root,arCOG09584@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2346639_17	323259.Mhun_2228	3.519e-66	231.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,2N9PG@224756|Methanomicrobia	224756|Methanomicrobia	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
EH3_k127_2346639_9	593750.Metfor_2631	2.533e-78	266.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota	28890|Euryarchaeota	F	Belongs to the archaeal adenylate kinase family	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
EH3_k127_2346639_0	456442.Mboo_0555	1.868e-252	786.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,2N9AJ@224756|Methanomicrobia	224756|Methanomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
EH3_k127_2346639_21	679926.Mpet_2210	6.927e-54	192.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2N9U7@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
EH3_k127_2346639_10	456442.Mboo_0553	2.42e-76	262.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2N9JA@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM ribosomal protein L30P	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
EH3_k127_2346639_5	456442.Mboo_0552	4.593e-112	363.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,2N954@224756|Methanomicrobia	224756|Methanomicrobia	J	With S4 and S12 plays an important role in translational accuracy	rps5	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
EH3_k127_2346639_11	679926.Mpet_2207	4.856e-74	252.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2N9SW@224756|Methanomicrobia	224756|Methanomicrobia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
EH3_k127_2346639_18	521011.Mpal_0460	3.993e-64	222.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,2N9QQ@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
EH3_k127_2346639_23	368407.Memar_0581	3.411e-41	155.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,2N9TN@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
EH3_k127_2346639_13	456442.Mboo_0548	2.101e-69	240.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,2N9KP@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
EH3_k127_2346639_19	593750.Metfor_2640	1.572e-62	216.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2N9Q6@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
EH3_k127_2346639_27	456442.Mboo_0546	2.871e-24	102.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y04R@28890|Euryarchaeota,2NA3T@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
EH3_k127_2346639_14	593750.Metfor_2642	2.879e-69	238.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,2N9KJ@224756|Methanomicrobia	224756|Methanomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
EH3_k127_2346639_4	593750.Metfor_2643	2.952e-114	372.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,2N9HR@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,RS4NT,Ribosomal_S4e,S4
EH3_k127_2346639_24	368407.Memar_0575	7.31e-41	153.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2N9XR@224756|Methanomicrobia	224756|Methanomicrobia	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
EH3_k127_2346639_12	456442.Mboo_0542	8.407e-70	239.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,2N9SH@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
EH3_k127_2346639_22	456442.Mboo_0541	3.625e-53	188.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
EH3_k127_2346639_26	368407.Memar_0572	1.377e-26	111.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,2NA4I@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
EH3_k127_2346639_29	323259.Mhun_2246	2.082e-23	100.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,2NA4R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
EH3_k127_2346639_6	521011.Mpal_0448	7.846e-112	365.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,2N95N@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
EH3_k127_2346639_15	368407.Memar_0569	4.677e-68	234.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,2N9UR@224756|Methanomicrobia	224756|Methanomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
EH3_k127_2346639_16	521011.Mpal_0446	1.599e-67	231.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,2N9PW@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
EH3_k127_2346639_3	456442.Mboo_0535	3.885e-130	417.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,2N99T@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
EH3_k127_2346639_25	456442.Mboo_0534	1.107e-28	116.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,2N9ZC@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
EH3_k127_2346639_8	593750.Metfor_2654	1.06e-109	359.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,2N9DG@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
EH3_k127_2346639_1	456442.Mboo_0532	4.657e-170	538.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,2N98A@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
EH3_k127_2346639_20	368407.Memar_0563	6.716e-61	212.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,2NB55@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM sigma-70 region 4 domain protein	-	-	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
EH3_k127_2346639_2	456442.Mboo_0530	2.409e-153	487.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,2N9GS@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
EH3_k127_2346639_7	456442.Mboo_0529	5.088e-110	363.0	COG1085@1|root,arCOG00420@2157|Archaea,2XWY6@28890|Euryarchaeota	28890|Euryarchaeota	C	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2346639_28	456442.Mboo_0528	1.232e-23	100.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
EH3_k127_2376868_4	456442.Mboo_0428	7.076e-52	185.0	COG2041@1|root,arCOG00266@2157|Archaea,2Y690@28890|Euryarchaeota,2NAWR@224756|Methanomicrobia	224756|Methanomicrobia	S	Oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
EH3_k127_2376868_0	192952.MM_0843	1.064e-215	681.0	COG1541@1|root,arCOG02622@2157|Archaea,2XVU6@28890|Euryarchaeota,2N93X@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
EH3_k127_2376868_2	456442.Mboo_0561	3.024e-66	231.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota	28890|Euryarchaeota	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
EH3_k127_2376868_1	593750.Metfor_2627	6.802e-108	358.0	COG4866@1|root,arCOG05191@2157|Archaea	2157|Archaea	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
EH3_k127_2376868_5	368407.Memar_1021	1.596e-45	168.0	COG0454@1|root,arCOG00839@2157|Archaea,2Y20T@28890|Euryarchaeota,2NA2S@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
EH3_k127_2376868_3	456442.Mboo_0558	2.872e-61	217.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,2N9PR@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
EH3_k127_2376868_6	593750.Metfor_2630	2.641e-34	133.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,2N9PG@224756|Methanomicrobia	224756|Methanomicrobia	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
EH3_k127_2381339_1	456442.Mboo_0184	6.537e-146	467.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2N91B@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-2	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
EH3_k127_2381339_0	368407.Memar_2348	6.341e-173	551.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,2N9EI@224756|Methanomicrobia	224756|Methanomicrobia	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
EH3_k127_2381339_2	694440.JOMF01000004_gene1349	0.0002299	47.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,2N98I@224756|Methanomicrobia	224756|Methanomicrobia	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
EH3_k127_2424149_3	456442.Mboo_0056	4.89e-115	375.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9D7@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_2424149_7	593750.Metfor_0113	1.779e-68	234.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,2N9NP@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
EH3_k127_2424149_5	593750.Metfor_0114	1.359e-80	271.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,2N9J0@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM riboflavin synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
EH3_k127_2424149_1	456442.Mboo_0053	2.698e-185	586.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,2N9EM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
EH3_k127_2424149_8	368407.Memar_0055	3.982e-52	186.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
EH3_k127_2424149_0	521011.Mpal_0416	1.036e-199	629.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,2N91J@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine biosynthesis protein ThiC	thiC-1	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
EH3_k127_2424149_4	456442.Mboo_0043	7.322e-82	276.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2N9QR@224756|Methanomicrobia	224756|Methanomicrobia	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
EH3_k127_2424149_9	679926.Mpet_0325	3.192e-35	149.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,2NB15@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
EH3_k127_2424149_6	593750.Metfor_0134	1.967e-80	282.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVMU@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
EH3_k127_2424149_2	368407.Memar_0048	1.399e-150	481.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota,2N942@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH-1	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
EH3_k127_2433587_1	323259.Mhun_1134	2.578e-30	122.0	COG1745@1|root,arCOG02254@2157|Archaea	2157|Archaea	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
EH3_k127_2433587_0	456442.Mboo_1956	1.661e-227	715.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,2N9D5@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM histone acetyltransferase, ELP3 family	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
EH3_k127_2505922_2	456442.Mboo_0524	1.418e-33	139.0	arCOG03260@1|root,arCOG03260@2157|Archaea,2Y7UA@28890|Euryarchaeota,2NAMH@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2505922_0	456442.Mboo_0523	1.96e-243	760.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,2N9C6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,Molydop_binding,PYNP_C
EH3_k127_2505922_1	323259.Mhun_2263	3.991e-62	220.0	arCOG03906@1|root,arCOG03906@2157|Archaea,2XUWK@28890|Euryarchaeota	28890|Euryarchaeota	DZ	Domain of unknown function (DUF3821)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3821
EH3_k127_2548852_0	521011.Mpal_1701	1.441e-165	529.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,2N963@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
EH3_k127_2548852_1	521011.Mpal_1699	4.986e-89	299.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,2N91F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DEAD_2 domain protein	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
EH3_k127_2673857_1	521011.Mpal_0712	8.251e-53	190.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,2NBE1@224756|Methanomicrobia	224756|Methanomicrobia	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4,HTH_5
EH3_k127_2673857_0	593750.Metfor_2571	1.331e-67	234.0	COG1839@1|root,arCOG04298@2157|Archaea,2XY40@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
EH3_k127_2673857_3	410358.Mlab_0285	5.114e-09	58.0	arCOG04838@1|root,arCOG04838@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2673857_2	641491.DND132_2748	6.363e-14	78.0	COG0506@1|root,COG0506@2|Bacteria,1R8VR@1224|Proteobacteria,42P21@68525|delta/epsilon subdivisions,2WJU2@28221|Deltaproteobacteria,2M89P@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
EH3_k127_2714354_3	521011.Mpal_2698	3.608e-29	121.0	COG0856@1|root,arCOG00028@2157|Archaea,2XU2R@28890|Euryarchaeota,2N9NM@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	pyrE-2	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
EH3_k127_2714354_2	368407.Memar_0273	1.152e-46	174.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,2NA00@224756|Methanomicrobia	224756|Methanomicrobia	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
EH3_k127_2714354_0	368407.Memar_0274	1.941e-102	343.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2N9B3@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
EH3_k127_2714354_1	593750.Metfor_0293	3.56e-100	333.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,2N92A@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
EH3_k127_2790854_0	368407.Memar_2247	3.423e-124	404.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,2N9B7@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,RIO1
EH3_k127_2790854_1	368407.Memar_2248	1.714e-65	228.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,2N9KV@224756|Methanomicrobia	224756|Methanomicrobia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
EH3_k127_2790854_2	368407.Memar_2249	7.973e-08	53.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota,2NB9F@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
EH3_k127_283930_0	593750.Metfor_2496	2.965e-178	568.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
EH3_k127_283930_2	593750.Metfor_2498	1.855e-24	107.0	COG1254@1|root,arCOG01674@2157|Archaea	2157|Archaea	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
EH3_k127_283930_1	593750.Metfor_2499	1.879e-82	284.0	COG1518@1|root,arCOG01452@2157|Archaea	2157|Archaea	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas1
EH3_k127_283930_3	679926.Mpet_0402	1.979e-06	49.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N9EC@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
EH3_k127_2841032_2	521011.Mpal_2060	2.609e-116	380.0	COG0516@1|root,arCOG00612@2157|Archaea,2XU40@28890|Euryarchaeota,2NAPF@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
EH3_k127_2841032_3	521011.Mpal_2061	4.328e-98	325.0	COG1891@1|root,arCOG04482@2157|Archaea,2XUBQ@28890|Euryarchaeota,2N952@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P)	mfnB	-	4.2.3.153	ko:K09733	ko00680,map00680	-	R10935	RC03315	ko00000,ko00001,ko01000	-	-	-	4HFCP_synth
EH3_k127_2841032_4	521011.Mpal_2062	4.856e-77	263.0	COG1411@1|root,arCOG00616@2157|Archaea,2XYJ0@28890|Euryarchaeota,2N9PP@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
EH3_k127_2841032_5	593750.Metfor_1274	6.414e-73	252.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2N9Y8@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
EH3_k127_2841032_0	456442.Mboo_1721	0.0	1285.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
EH3_k127_2841032_1	368407.Memar_1573	1.059e-123	411.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
EH3_k127_2841032_6	368407.Memar_1575	3.764e-49	184.0	arCOG04389@1|root,arCOG04389@2157|Archaea,2XWXD@28890|Euryarchaeota	28890|Euryarchaeota	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2897051_2	368407.Memar_0658	7.089e-91	303.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
EH3_k127_2897051_0	368407.Memar_0659	1.022e-129	420.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N9HU@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
EH3_k127_2897051_1	593750.Metfor_0764	2.635e-115	386.0	COG4637@1|root,arCOG03241@2157|Archaea	2157|Archaea	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
EH3_k127_2897051_3	1231241.Mc24_08439	4.213e-41	158.0	2ECM2@1|root,336J2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
EH3_k127_2897051_4	593750.Metfor_1502	1.913e-22	99.0	COG2061@1|root,arCOG04396@2157|Archaea,2XWMD@28890|Euryarchaeota,2N9PF@224756|Methanomicrobia	224756|Methanomicrobia	E	amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_2914651_3	679926.Mpet_2695	4.926e-25	110.0	COG0456@1|root,arCOG00833@2157|Archaea	2157|Archaea	C	PFAM GCN5-related N-acetyltransferase	-	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
EH3_k127_2914651_1	368407.Memar_1334	1.375e-42	160.0	COG0314@1|root,arCOG00534@2157|Archaea,2XZG1@28890|Euryarchaeota	28890|Euryarchaeota	H	Molybdopterin converting factor	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
EH3_k127_2914651_4	368407.Memar_1335	1.218e-19	92.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
EH3_k127_2914651_0	368407.Memar_1336	4.939e-86	291.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1238	ThiF
EH3_k127_2914651_2	593750.Metfor_0805	2.511e-42	162.0	COG1606@1|root,arCOG00043@2157|Archaea,2XV2X@28890|Euryarchaeota,2N9N2@224756|Methanomicrobia	224756|Methanomicrobia	S	PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase,QueC
EH3_k127_2920184_3	593750.Metfor_2676	1.264e-89	299.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH3_k127_2920184_2	368407.Memar_0538	1.348e-101	341.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
EH3_k127_2920184_4	368407.Memar_0539	3.916e-81	278.0	COG1587@1|root,arCOG02048@2157|Archaea,2Y267@28890|Euryarchaeota,2N9PI@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
EH3_k127_2920184_0	368407.Memar_0540	2.219e-122	404.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,2N9A6@224756|Methanomicrobia	224756|Methanomicrobia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
EH3_k127_2920184_5	368407.Memar_0541	4.409e-77	267.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,2N9S7@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
EH3_k127_2920184_6	521011.Mpal_2744	1.855e-72	249.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,2N9QB@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
EH3_k127_2920184_1	456442.Mboo_0521	3.791e-111	363.0	COG0207@1|root,arCOG03214@2157|Archaea,2XTCY@28890|Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
EH3_k127_2920184_7	456442.Mboo_0705	3.327e-08	58.0	COG5184@1|root,arCOG08219@2157|Archaea	2157|Archaea	DZ	Domain of unknown function (DUF3821)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3821,Lipase_GDSL_2
EH3_k127_3120267_0	521011.Mpal_0394	7.87e-228	713.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,2N978@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
EH3_k127_3120267_5	521011.Mpal_0395	4.569e-25	104.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,2NA67@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
EH3_k127_3120267_4	593750.Metfor_0049	6.105e-38	145.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,2NA2C@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Like-Sm ribonucleoprotein, core	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
EH3_k127_3120267_1	368407.Memar_0231	2.16e-65	228.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,2N9WM@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
EH3_k127_3120267_2	456442.Mboo_0091	1.089e-47	173.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2N9X3@224756|Methanomicrobia	224756|Methanomicrobia	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
EH3_k127_3120267_3	521011.Mpal_0399	4.175e-40	149.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2N9T4@224756|Methanomicrobia	224756|Methanomicrobia	S	ZPR1-related zinc finger protein	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
EH3_k127_3215906_2	323259.Mhun_2592	2.315e-33	129.0	COG1143@1|root,arCOG01543@2157|Archaea,2XYQV@28890|Euryarchaeota	28890|Euryarchaeota	C	Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I)	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
EH3_k127_3215906_1	679926.Mpet_1563	2.928e-38	149.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0IM@28890|Euryarchaeota,2NBF7@224756|Methanomicrobia	224756|Methanomicrobia	O	Hydrogenase maturation protease	-	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
EH3_k127_3215906_3	368407.Memar_1051	2.352e-22	102.0	COG3187@1|root,arCOG03952@2157|Archaea,2Y55P@28890|Euryarchaeota,2NBFA@224756|Methanomicrobia	224756|Methanomicrobia	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
EH3_k127_3215906_0	456442.Mboo_0218	2.188e-48	177.0	COG0394@1|root,arCOG04425@2157|Archaea,2XZ4R@28890|Euryarchaeota,2N9TH@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
EH3_k127_3320301_0	593750.Metfor_0356	2.033e-285	886.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,2N96H@224756|Methanomicrobia	224756|Methanomicrobia	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
EH3_k127_3320301_15	593750.Metfor_0355	6.566e-51	183.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2N9XB@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
EH3_k127_3320301_16	593750.Metfor_0353	4.352e-44	167.0	COG3612@1|root,arCOG04418@2157|Archaea,2XXT8@28890|Euryarchaeota,2NA4A@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
EH3_k127_3320301_24	1121413.JMKT01000009_gene1934	6.767e-05	49.0	2DNS2@1|root,32YVY@2|Bacteria,1N9QQ@1224|Proteobacteria,42X5E@68525|delta/epsilon subdivisions,2WSAR@28221|Deltaproteobacteria,2MGI0@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3320301_13	521011.Mpal_0336	1.877e-53	191.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,2N9UK@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein S8E	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
EH3_k127_3320301_5	456442.Mboo_2308	1.905e-105	345.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,2N9SQ@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
EH3_k127_3320301_22	593750.Metfor_0349	1.111e-23	103.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68X@28890|Euryarchaeota,2NA5V@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
EH3_k127_3320301_8	593750.Metfor_0348	2.375e-89	299.0	COG1387@1|root,arCOG00304@2157|Archaea,2XVZY@28890|Euryarchaeota,2N90M@224756|Methanomicrobia	224756|Methanomicrobia	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
EH3_k127_3320301_23	593750.Metfor_0347	4.39e-22	97.0	COG3277@1|root,arCOG02466@2157|Archaea	2157|Archaea	J	RNA-binding protein involved in rRNA processing	gar1	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
EH3_k127_3320301_2	456442.Mboo_2311	6.203e-203	635.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
EH3_k127_3320301_10	368407.Memar_1661	9.354e-63	220.0	COG0235@1|root,arCOG04226@2157|Archaea,2XYQT@28890|Euryarchaeota,2N9R0@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
EH3_k127_3320301_7	593750.Metfor_1333	2.479e-90	302.0	COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,2N9SI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
EH3_k127_3320301_18	521011.Mpal_1024	8.732e-35	136.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZ0C@28890|Euryarchaeota,2NB68@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
EH3_k127_3320301_3	593750.Metfor_1331	2.425e-184	588.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,2N9BA@224756|Methanomicrobia	224756|Methanomicrobia	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
EH3_k127_3320301_6	368407.Memar_1655	1.015e-97	329.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,2N9GN@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
EH3_k127_3320301_19	368407.Memar_1654	4.422e-32	128.0	arCOG04419@1|root,arCOG04419@2157|Archaea,2XZTP@28890|Euryarchaeota,2N9ZJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2551)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2551
EH3_k127_3320301_21	368407.Memar_1653	3.718e-25	108.0	arCOG05136@1|root,arCOG05136@2157|Archaea,2Y1BS@28890|Euryarchaeota,2NA5R@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3320301_20	456442.Mboo_1793	3.024e-31	130.0	COG1371@1|root,arCOG04055@2157|Archaea	2157|Archaea	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	Archease
EH3_k127_3320301_1	323259.Mhun_3181	3.984e-232	725.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,2N90W@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
EH3_k127_3320301_9	521011.Mpal_1017	1.728e-66	231.0	arCOG04998@1|root,arCOG04998@2157|Archaea,2XZR1@28890|Euryarchaeota,2N9VB@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3320301_11	593750.Metfor_1324	3.766e-58	205.0	COG4048@1|root,arCOG04902@2157|Archaea,2Y8FE@28890|Euryarchaeota,2N9Y6@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111
EH3_k127_3320301_4	456442.Mboo_1789	7.711e-155	494.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,2N982@224756|Methanomicrobia	224756|Methanomicrobia	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
EH3_k127_3320301_14	521011.Mpal_1014	5.356e-52	189.0	COG1268@1|root,arCOG02986@2157|Archaea,2XWSG@28890|Euryarchaeota,2N9UN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM BioY protein	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
EH3_k127_3320301_12	456442.Mboo_1787	1.761e-57	207.0	COG3839@1|root,arCOG00211@2157|Archaea	2157|Archaea	G	PFAM ABC transporter	-	-	-	ko:K16786	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
EH3_k127_3320301_17	368407.Memar_1645	3.811e-39	152.0	COG1122@1|root,arCOG00188@2157|Archaea	2157|Archaea	P	PFAM ABC transporter related	phnG	-	2.7.8.37	ko:K02068,ko:K03529,ko:K06166,ko:K16786,ko:K16787	ko00440,ko02010,map00440,map02010	M00211,M00582	R10185	RC00005,RC00063	ko00000,ko00001,ko00002,ko01000,ko02000,ko03036	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,PhnG,SMC_N,SMC_hinge
EH3_k127_3346676_1	521011.Mpal_0037	1.042e-164	525.0	COG0436@1|root,arCOG01133@2157|Archaea,2XU6A@28890|Euryarchaeota,2N9FK@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_3346676_6	582515.KR51_00036130	2.064e-25	109.0	COG1324@1|root,COG1324@2|Bacteria,1G7PJ@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
EH3_k127_3346676_3	368407.Memar_1911	8.595e-71	246.0	COG1526@1|root,arCOG04358@2157|Archaea,2XY65@28890|Euryarchaeota,2NBJ5@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM formate dehydrogenase family accessory protein FdhD	-	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
EH3_k127_3346676_5	593750.Metfor_0756	5.591e-56	199.0	COG4081@1|root,arCOG04845@2157|Archaea,2XXFT@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1890
EH3_k127_3346676_7	456320.Mvol_0335	9.16e-17	83.0	COG4033@1|root,arCOG04844@2157|Archaea,2XYZ8@28890|Euryarchaeota,23R60@183939|Methanococci	183939|Methanococci	S	PFAM Uncharacterised conserved protein UCP006577	-	-	-	-	-	-	-	-	-	-	-	-	DUF1894
EH3_k127_3346676_0	593750.Metfor_0760	2.397e-196	626.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
EH3_k127_3346676_2	456442.Mboo_2090	1.279e-117	384.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,2N9NQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
EH3_k127_3346676_4	593750.Metfor_0763	3.059e-66	231.0	COG4843@1|root,arCOG06902@2157|Archaea	2157|Archaea	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
EH3_k127_3346676_8	521011.Mpal_2748	2.485e-12	68.0	arCOG03597@1|root,arCOG03597@2157|Archaea,2Y07Y@28890|Euryarchaeota,2NBAH@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
EH3_k127_3346780_3	1041930.Mtc_2336	5.817e-17	81.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
EH3_k127_3346780_2	593750.Metfor_0257	5.79e-35	138.0	COG1436@1|root,arCOG04102@2157|Archaea,2XZ62@28890|Euryarchaeota,2NB4R@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF-2	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
EH3_k127_3346780_0	1041930.Mtc_2334	4.485e-300	927.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2NANC@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA-2	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
EH3_k127_3346780_1	304371.MCP_2291	2.138e-253	785.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2NAB4@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB-2	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
EH3_k127_3350388_0	593750.Metfor_0752	3.376e-176	555.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
EH3_k127_3350388_6	694440.JOMF01000004_gene1108	1.301e-66	237.0	COG0561@1|root,arCOG01213@2157|Archaea,2XX94@28890|Euryarchaeota,2N9JY@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the dephosphorylation of 2-phosphoglycolate	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
EH3_k127_3350388_2	456442.Mboo_2102	1.233e-129	419.0	COG2524@1|root,arCOG00610@2157|Archaea,2XVPF@28890|Euryarchaeota,2N96A@224756|Methanomicrobia	224756|Methanomicrobia	K	signal transduction protein with CBS domains	-	-	-	ko:K07744	-	-	-	-	ko00000	-	-	-	CBS,HrcA_DNA-bdg
EH3_k127_3350388_3	456442.Mboo_2103	3.591e-125	407.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2N941@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
EH3_k127_3350388_4	593750.Metfor_0714	6.269e-95	319.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
EH3_k127_3350388_7	593750.Metfor_0713	3.521e-14	77.0	arCOG04995@1|root,arCOG04995@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3350388_1	456442.Mboo_2106	1.006e-144	465.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,2N9EE@224756|Methanomicrobia	224756|Methanomicrobia	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
EH3_k127_3350388_5	368407.Memar_1904	5.428e-77	262.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,2N9N5@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
EH3_k127_3350388_8	368407.Memar_1903	2.438e-06	49.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,2N9V1@224756|Methanomicrobia	224756|Methanomicrobia	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
EH3_k127_3357624_1	456442.Mboo_1444	1.5e-46	169.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
EH3_k127_3357624_0	456442.Mboo_1443	2.541e-246	767.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,2N9B4@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
EH3_k127_3404363_4	456442.Mboo_1327	5.745e-31	126.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,2N9PQ@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidylprolyl isomerase FKBP-type	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
EH3_k127_3404363_3	521011.Mpal_1572	2.632e-49	181.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,2N9TV@224756|Methanomicrobia	224756|Methanomicrobia	F	adenylyl cyclase CyaB	cyaB	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
EH3_k127_3404363_1	593750.Metfor_1531	9.649e-90	299.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXXF@28890|Euryarchaeota,2N9PM@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
EH3_k127_3404363_0	368407.Memar_0931	5.05e-143	462.0	COG1032@1|root,arCOG01356@2157|Archaea,2XUA3@28890|Euryarchaeota,2N9AZ@224756|Methanomicrobia	224756|Methanomicrobia	C	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
EH3_k127_3404363_5	521011.Mpal_1312	2.296e-19	93.0	arCOG07676@1|root,arCOG07676@2157|Archaea	2157|Archaea	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3404363_2	456442.Mboo_1457	4.623e-53	190.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
EH3_k127_3404363_6	368407.Memar_1308	7.302e-12	70.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N947@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM 26S proteasome subunit P45 family	pan-1	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
EH3_k127_3409812_3	593750.Metfor_0315	8.657e-48	172.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
EH3_k127_3409812_4	1210908.HSB1_17600	3.314e-21	96.0	COG1436@1|root,arCOG04102@2157|Archaea,2XXYI@28890|Euryarchaeota,23W7A@183963|Halobacteria	183963|Halobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
EH3_k127_3409812_1	593750.Metfor_0313	1.325e-129	422.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
EH3_k127_3409812_2	593750.Metfor_0312	1.356e-57	210.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,2N9TB@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
EH3_k127_3409812_5	521011.Mpal_2681	5.474e-20	92.0	COG0636@1|root,arCOG02455@2157|Archaea,2XZRP@28890|Euryarchaeota,2N9ZA@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM H transporting two-sector ATPase C subunit	atpK-1	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0390	ATP-synt_C
EH3_k127_3409812_0	368407.Memar_0282	1.897e-233	739.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
EH3_k127_3419632_0	593750.Metfor_0695	1.826e-178	567.0	COG0847@1|root,arCOG06460@2157|Archaea,2XZQV@28890|Euryarchaeota	28890|Euryarchaeota	L	P-loop Domain of unknown function (DUF2791)	-	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	DUF2791
EH3_k127_3419632_1	593750.Metfor_0696	1.029e-123	420.0	arCOG03042@1|root,arCOG03042@2157|Archaea	2157|Archaea	KLT	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3419632_2	593750.Metfor_0697	1.067e-74	259.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y7SU@28890|Euryarchaeota,2NAYT@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
EH3_k127_3419632_3	593750.Metfor_0698	1.73e-23	102.0	arCOG08217@1|root,arCOG08217@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3419632_4	368407.Memar_1898	5.615e-11	72.0	COG2050@1|root,arCOG00777@2157|Archaea,2Y26I@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
EH3_k127_3429020_3	368407.Memar_1237	2.083e-77	268.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
EH3_k127_3429020_2	323259.Mhun_0828	2.207e-101	342.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
EH3_k127_3429020_5	593750.Metfor_1348	1.656e-25	109.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,2N9YQ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
EH3_k127_3429020_0	368407.Memar_1240	1.671e-112	369.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,2N9EW@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM TatD-related deoxyribonuclease	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
EH3_k127_3429020_4	410358.Mlab_0831	3.37e-32	129.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,2N9TR@224756|Methanomicrobia	224756|Methanomicrobia	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
EH3_k127_3429020_1	521011.Mpal_2104	4.894e-109	357.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,2N9E6@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
EH3_k127_3450562_2	456442.Mboo_0207	9.484e-52	186.0	COG0475@1|root,arCOG01955@2157|Archaea,2XT4U@28890|Euryarchaeota	28890|Euryarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
EH3_k127_3450562_0	456442.Mboo_0206	3.745e-68	236.0	COG0490@1|root,arCOG01970@2157|Archaea,2XWSV@28890|Euryarchaeota	28890|Euryarchaeota	P	regulatory, ligand-binding protein related to C-terminal domains of K channels	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
EH3_k127_3450562_4	368407.Memar_0249	8.799e-12	69.0	arCOG04907@1|root,arCOG04907@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3450562_3	857293.CAAU_0099	6.687e-38	147.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,36I0G@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
EH3_k127_3450562_1	368407.Memar_0350	1.692e-53	190.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,2NAB8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
EH3_k127_3469505_2	456442.Mboo_1002	7.075e-48	176.0	arCOG05293@1|root,arCOG05293@2157|Archaea	2157|Archaea	G	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3469505_1	391623.TERMP_01962	7.147e-57	207.0	COG1573@1|root,arCOG00905@2157|Archaea,2XUVI@28890|Euryarchaeota,243FM@183968|Thermococci	183968|Thermococci	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
EH3_k127_3469505_0	593750.Metfor_0631	1.108e-83	285.0	COG0655@1|root,arCOG02574@2157|Archaea	2157|Archaea	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
EH3_k127_3475571_0	593750.Metfor_2111	0.0	1312.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,2N92M@224756|Methanomicrobia	224756|Methanomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2374	CPSase_L_D2,CPSase_L_D3,MGS
EH3_k127_3475571_1	593750.Metfor_2113	2.204e-207	649.0	COG0137@1|root,arCOG00112@2157|Archaea,2XU8K@28890|Euryarchaeota,2N9DR@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
EH3_k127_3475571_2	368407.Memar_0996	3.596e-31	124.0	COG3576@1|root,arCOG00518@2157|Archaea,2XYMW@28890|Euryarchaeota,2N9U6@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
EH3_k127_3476928_3	323261.Noc_0358	5.426e-05	53.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales	135613|Chromatiales	P	Chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
EH3_k127_3476928_1	593750.Metfor_0988	1.562e-76	268.0	COG1226@1|root,arCOG01964@2157|Archaea,2Y19J@28890|Euryarchaeota,2NADN@224756|Methanomicrobia	224756|Methanomicrobia	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
EH3_k127_3476928_0	456442.Mboo_1053	1.822e-77	264.0	COG4749@1|root,arCOG04411@2157|Archaea,2XT50@28890|Euryarchaeota,2N9VH@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2150)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2150
EH3_k127_3476928_2	456442.Mboo_1054	4.397e-55	195.0	COG1202@1|root,arCOG03143@2157|Archaea,2XWI3@28890|Euryarchaeota	28890|Euryarchaeota	S	COG1202 Superfamily II helicase, archaea-specific	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3483268_0	593750.Metfor_2544	2.454e-158	505.0	COG0535@1|root,arCOG00956@2157|Archaea,2XU9R@28890|Euryarchaeota,2N96X@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
EH3_k127_3483268_2	237368.SCABRO_01859	1.141e-14	75.0	arCOG09503@1|root,33HQ7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3483268_1	456442.Mboo_0664	1.483e-15	81.0	arCOG09427@1|root,arCOG09427@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3513165_12	456442.Mboo_1860	1.288e-05	48.0	arCOG12704@1|root,arCOG12704@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3513165_4	323259.Mhun_0672	8.6e-153	486.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,2N9CI@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
EH3_k127_3513165_0	593750.Metfor_1747	7.417e-190	603.0	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,2N96K@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source	cbiA-1	-	6.3.5.12	ko:K22012	ko00860,map00860	M00836	R11627	-	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
EH3_k127_3513165_1	368407.Memar_1733	3.495e-178	563.0	COG2710@1|root,arCOG04888@2157|Archaea,2XUYC@28890|Euryarchaeota,2N90I@224756|Methanomicrobia	224756|Methanomicrobia	C	Methanogenesis marker 13 metalloprotein	-	-	6.3.3.7	ko:K21611	ko00860,ko01120,map00860,map01120	M00836	R11628	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
EH3_k127_3513165_6	368407.Memar_1732	4.928e-120	397.0	COG0770@1|root,arCOG02822@2157|Archaea,2XX2Y@28890|Euryarchaeota,2N9JG@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Mur ligase, middle domain protein	murD	-	6.4.1.9	ko:K21612	ko00860,ko01120,map00860,map01120	M00836	R11629	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
EH3_k127_3513165_9	456442.Mboo_1417	4.807e-58	203.0	COG2138@1|root,arCOG02246@2157|Archaea,2XTSY@28890|Euryarchaeota,2N9W8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin	cbiX	-	4.99.1.11,4.99.1.3	ko:K22011	ko00860,ko01100,map00860,map01100	M00836	R05807,R11626	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2400	CbiX
EH3_k127_3513165_3	521011.Mpal_0683	7.048e-167	531.0	COG0042@1|root,arCOG00605@2157|Archaea,2XU1I@28890|Euryarchaeota,2N9FE@224756|Methanomicrobia	224756|Methanomicrobia	J	Dihydrouridine synthase (Dus)	-	-	-	-	-	-	-	-	-	-	-	-	Dus
EH3_k127_3513165_7	368407.Memar_1728	1.086e-113	372.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,2N9HM@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM triphosphoribosyl-dephospho-CoA protein	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
EH3_k127_3513165_10	521011.Mpal_0685	9.82e-46	173.0	COG2457@1|root,arCOG04458@2157|Archaea,2XZFN@28890|Euryarchaeota,2N9V4@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
EH3_k127_3513165_2	456442.Mboo_1413	1.51e-170	539.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,2N97M@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
EH3_k127_3513165_11	456442.Mboo_1412	2.183e-43	162.0	COG0375@1|root,arCOG04426@2157|Archaea,2Y0W9@28890|Euryarchaeota,2NB6Y@224756|Methanomicrobia	224756|Methanomicrobia	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
EH3_k127_3513165_8	593750.Metfor_1712	1.626e-62	222.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota,2NB98@224756|Methanomicrobia	224756|Methanomicrobia	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
EH3_k127_3513165_5	593750.Metfor_1710	8.925e-151	482.0	COG1907@1|root,arCOG01026@2157|Archaea	2157|Archaea	H	Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P)	-	-	2.4.2.54	ko:K06984	ko00790,map00790	-	R10337,R11102	-	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
EH3_k127_3554120_0	593750.Metfor_1626	6.453e-296	915.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,2N92F@224756|Methanomicrobia	224756|Methanomicrobia	L	acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DnaJ_CXXCXGXG,S1,tRNA_anti-codon
EH3_k127_3554120_1	593750.Metfor_1625	1.212e-139	450.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
EH3_k127_3554120_2	456442.Mboo_1592	2.441e-108	357.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2N9NR@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH3_k127_3554120_4	323259.Mhun_1714	1.891e-44	168.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2N9RC@224756|Methanomicrobia	224756|Methanomicrobia	H	adenyl ribonucleotide binding	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0975	AAA_17,RNA_binding
EH3_k127_3554120_3	593750.Metfor_1622	7.767e-72	252.0	COG1180@1|root,arCOG00952@2157|Archaea,2XZ0I@28890|Euryarchaeota,2N9XE@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	nrdG	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
EH3_k127_3565874_1	521011.Mpal_0692	4.704e-45	164.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
EH3_k127_3565874_2	456442.Mboo_1926	1.242e-35	138.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y12M@28890|Euryarchaeota,2N9YP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3565874_0	593750.Metfor_1041	2.589e-254	793.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
EH3_k127_3605691_5	593750.Metfor_0332	1.961e-40	151.0	arCOG02780@1|root,arCOG02780@2157|Archaea,2XZQI@28890|Euryarchaeota,2N9W5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3605691_3	456442.Mboo_2329	1.444e-142	465.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2
EH3_k127_3605691_4	639282.DEFDS_0235	8.119e-126	421.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GF76@200930|Deferribacteres	200930|Deferribacteres	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
EH3_k127_3605691_2	292415.Tbd_0367	5.333e-154	508.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3605691_0	521011.Mpal_1009	3.416e-263	816.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
EH3_k127_3605691_1	593750.Metfor_1318	6.409e-191	602.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,2N90X@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM oxaloacetate decarboxylase alpha subunit	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1586	Biotin_lipoyl,HMGL-like,PYC_OADA
EH3_k127_3632214_11	593750.Metfor_2676	1.901e-26	113.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH3_k127_3632214_5	456442.Mboo_0504	1.006e-77	265.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,2N9JS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
EH3_k127_3632214_0	593750.Metfor_2678	2.836e-300	930.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,2N93H@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
EH3_k127_3632214_12	521011.Mpal_2760	5.368e-26	113.0	arCOG06929@1|root,arCOG06929@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3632214_7	593750.Metfor_2680	1.296e-59	212.0	arCOG05307@1|root,arCOG05307@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3632214_1	456442.Mboo_0501	2.455e-133	437.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,2N9GQ@224756|Methanomicrobia	224756|Methanomicrobia	J	SMART Elongator protein 3 MiaB NifB	miaB	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
EH3_k127_3632214_3	593750.Metfor_2687	6.342e-108	355.0	COG1712@1|root,arCOG00254@2157|Archaea,2XXKF@28890|Euryarchaeota,2N96R@224756|Methanomicrobia	224756|Methanomicrobia	H	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21,5.3.3.2	ko:K01823,ko:K06989	ko00760,ko00900,ko01100,ko01110,ko01130,map00760,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123,R07407,R07410	RC00455,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF108,NAD_binding_3
EH3_k127_3632214_2	368407.Memar_0820	7.149e-120	391.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
EH3_k127_3632214_4	593750.Metfor_2688	2.213e-91	308.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,2N950@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
EH3_k127_3632214_8	593750.Metfor_2689	1.795e-47	178.0	COG5635@1|root,arCOG02967@2157|Archaea	2157|Archaea	T	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
EH3_k127_3632214_13	368407.Memar_2451	3.21e-24	106.0	arCOG03400@1|root,arCOG03400@2157|Archaea	2157|Archaea	F	nucleic acid binding OB-fold tRNA helicase-type	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-codon
EH3_k127_3632214_10	521011.Mpal_2597	2.538e-28	115.0	COG0640@1|root,arCOG00394@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HTH_24,HTH_27,HTH_5
EH3_k127_3632214_9	593750.Metfor_2692	2.062e-31	126.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y1WV@28890|Euryarchaeota,2NA61@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
EH3_k127_3632214_6	368407.Memar_2448	8.201e-61	214.0	COG1502@1|root,arCOG02039@2157|Archaea,2XTH3@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	pld	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
EH3_k127_367770_7	593750.Metfor_2528	2.665e-36	145.0	arCOG02874@1|root,arCOG02874@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_367770_1	593750.Metfor_2527	6.165e-211	661.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2N96D@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC-1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_367770_2	593750.Metfor_2526	3.096e-83	284.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,2NA3A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
EH3_k127_367770_3	521011.Mpal_1556	5.336e-76	260.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,2N9VP@224756|Methanomicrobia	224756|Methanomicrobia	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
EH3_k127_367770_4	368407.Memar_0718	2.442e-66	228.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2N9MF@224756|Methanomicrobia	224756|Methanomicrobia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iAF692.Mbar_A3385	NDK
EH3_k127_367770_9	521011.Mpal_0525	7.774e-30	119.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,2NA03@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
EH3_k127_367770_8	521011.Mpal_0524	2.887e-35	134.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,2N9ZH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
EH3_k127_367770_5	593750.Metfor_2521	6.733e-57	199.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2N9WX@224756|Methanomicrobia	224756|Methanomicrobia	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
EH3_k127_367770_0	456442.Mboo_0691	3.431e-219	700.0	COG5427@1|root,arCOG00563@2157|Archaea,2XV1K@28890|Euryarchaeota,2NAMT@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
EH3_k127_367770_6	593750.Metfor_2519	3.823e-50	182.0	COG0392@1|root,arCOG00897@2157|Archaea,2XT65@28890|Euryarchaeota,2NBAD@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
EH3_k127_3719976_10	323259.Mhun_2321	9.011e-18	85.0	COG1270@1|root,arCOG04274@2157|Archaea,2XT37@28890|Euryarchaeota,2N9JD@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
EH3_k127_3719976_11	456442.Mboo_0005	1.616e-17	85.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,2NA4S@224756|Methanomicrobia	224756|Methanomicrobia	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
EH3_k127_3719976_3	368407.Memar_0005	2.479e-175	554.0	COG0104@1|root,arCOG04387@2157|Archaea,2XT59@28890|Euryarchaeota,2N9T2@224756|Methanomicrobia	224756|Methanomicrobia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
EH3_k127_3719976_2	456442.Mboo_0003	3.051e-193	608.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N95M@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	iAF692.Mbar_A3463	Aminotran_1_2
EH3_k127_3719976_7	456442.Mboo_0002	5.947e-69	237.0	COG1522@1|root,arCOG01580@2157|Archaea,2XTN6@28890|Euryarchaeota,2N9R1@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
EH3_k127_3719976_1	593750.Metfor_0178	5.301e-219	685.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
EH3_k127_3719976_8	456442.Mboo_2460	1.987e-59	212.0	COG0521@1|root,arCOG00214@2157|Archaea,2XWJF@28890|Euryarchaeota,2N9SU@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM molybdenum cofactor synthesis domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
EH3_k127_3719976_9	323259.Mhun_2467	8.873e-35	139.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,2N9VU@224756|Methanomicrobia	224756|Methanomicrobia	S	KEOPS complex Cgi121-like subunit	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
EH3_k127_3719976_0	593750.Metfor_0182	7.619e-284	888.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
EH3_k127_3719976_6	593750.Metfor_0183	4.744e-77	262.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,2N9JJ@224756|Methanomicrobia	224756|Methanomicrobia	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
EH3_k127_3719976_4	593750.Metfor_0184	1.319e-104	347.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
EH3_k127_3719976_5	593750.Metfor_0185	7.042e-92	304.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,2N98T@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
EH3_k127_3742141_0	593750.Metfor_0225	2.144e-276	854.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N9CH@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
EH3_k127_3816197_12	323259.Mhun_0785	2.461e-17	81.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,2N9C9@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
EH3_k127_3816197_4	521011.Mpal_0111	4.499e-69	241.0	COG0020@1|root,arCOG01532@2157|Archaea,2XU1R@28890|Euryarchaeota,2N9SY@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Di-trans-poly-cis-decaprenylcistransferase	uppS-1	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
EH3_k127_3816197_1	521011.Mpal_0112	3.802e-199	634.0	COG1796@1|root,arCOG00305@2157|Archaea,2XT14@28890|Euryarchaeota,2N90T@224756|Methanomicrobia	224756|Methanomicrobia	L	Helix-hairpin-helix domain	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8
EH3_k127_3816197_9	521011.Mpal_0113	1.038e-40	158.0	COG1321@1|root,arCOG02099@2157|Archaea	2157|Archaea	K	iron dependent repressor	sirR	-	-	ko:K03709,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
EH3_k127_3816197_0	368407.Memar_1784	8.844e-221	701.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
EH3_k127_3816197_3	368407.Memar_1783	3.83e-95	319.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
EH3_k127_3816197_10	456442.Mboo_2069	9.841e-32	134.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,2NA0B@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
EH3_k127_3816197_2	368407.Memar_1781	4.498e-118	389.0	COG0392@1|root,arCOG00899@2157|Archaea,2XY3K@28890|Euryarchaeota,2NATI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
EH3_k127_3816197_8	368407.Memar_1780	5.548e-44	167.0	COG1259@1|root,arCOG01759@2157|Archaea,2XWIM@28890|Euryarchaeota,2NA0M@224756|Methanomicrobia	224756|Methanomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
EH3_k127_3816197_11	593750.Metfor_0781	2.701e-27	113.0	COG0140@1|root,arCOG02677@2157|Archaea,2XYNB@28890|Euryarchaeota,2NA17@224756|Methanomicrobia	224756|Methanomicrobia	E	phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
EH3_k127_3816197_5	593750.Metfor_0780	1.011e-56	201.0	COG0195@1|root,arCOG01760@2157|Archaea	2157|Archaea	K	transcription termination protein NusA	nusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
EH3_k127_3816197_6	368407.Memar_1773	4.213e-55	201.0	COG2968@1|root,arCOG04715@2157|Archaea,2XZAZ@28890|Euryarchaeota,2N9TF@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
EH3_k127_3816197_7	368407.Memar_1949	6.559e-50	181.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N97Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
EH3_k127_388921_4	593750.Metfor_1089	4.078e-29	117.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
EH3_k127_388921_2	456442.Mboo_1887	3.335e-62	217.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,2N9QY@224756|Methanomicrobia	224756|Methanomicrobia	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
EH3_k127_388921_5	593750.Metfor_1087	8.111e-23	100.0	COG1534@1|root,arCOG01346@2157|Archaea,2Y6W9@28890|Euryarchaeota,2NA5I@224756|Methanomicrobia	224756|Methanomicrobia	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
EH3_k127_388921_3	368407.Memar_1975	8.087e-30	123.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota	28890|Euryarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
EH3_k127_388921_1	368407.Memar_1976	6.146e-90	300.0	COG0299@1|root,arCOG02825@2157|Archaea,2Y838@28890|Euryarchaeota,2N9JE@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM formyl transferase domain protein	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2317	Formyl_trans_N
EH3_k127_388921_0	521011.Mpal_0531	9.142e-102	336.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,2N962@224756|Methanomicrobia	224756|Methanomicrobia	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
EH3_k127_3958730_0	679926.Mpet_1577	6.384e-72	250.0	COG0651@1|root,arCOG01537@2157|Archaea,2XU88@28890|Euryarchaeota,2NAW3@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
EH3_k127_3958730_3	439481.Aboo_0670	1.373e-34	135.0	COG1006@1|root,arCOG03072@2157|Archaea,2XZHS@28890|Euryarchaeota,3F3DH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
EH3_k127_3958730_2	439481.Aboo_0669	3.066e-48	179.0	COG2111@1|root,arCOG03079@2157|Archaea,2XZIA@28890|Euryarchaeota,3F3BU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Domain related to MnhB subunit of Na+/H+ antiporter	-	-	-	ko:K05566	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MnhB
EH3_k127_3958730_7	673860.AciM339_1158	6.406e-16	80.0	COG2111@1|root,arCOG03077@2157|Archaea,2Y00R@28890|Euryarchaeota,3F3GB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Membrane bound hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_3958730_6	673860.AciM339_1157	1.554e-21	98.0	COG1563@1|root,arCOG03078@2157|Archaea,2Y0QD@28890|Euryarchaeota,3F3HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Domain of unknown function (DUF4040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040
EH3_k127_3958730_4	323259.Mhun_2581	1.096e-33	133.0	COG1320@1|root,arCOG03082@2157|Archaea,2XZ52@28890|Euryarchaeota,2NBDI@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
EH3_k127_3958730_5	323259.Mhun_2580	3.239e-25	107.0	COG2212@1|root,arCOG03121@2157|Archaea,2Y0XI@28890|Euryarchaeota	28890|Euryarchaeota	P	Multisubunit Na H antiporter, MnhF subunit	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
EH3_k127_3958730_1	323259.Mhun_2579	8.398e-69	239.0	COG1863@1|root,arCOG03099@2157|Archaea,2XYYP@28890|Euryarchaeota	28890|Euryarchaeota	P	Multisubunit Na H antiporter MnhE subunit	-	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
EH3_k127_406850_4	693661.Arcve_1143	2.972e-08	57.0	COG0668@1|root,arCOG01568@2157|Archaea,2XUHN@28890|Euryarchaeota,245QV@183980|Archaeoglobi	183980|Archaeoglobi	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
EH3_k127_406850_1	368407.Memar_1776	1.074e-57	208.0	COG2430@1|root,arCOG01766@2157|Archaea,2XY9F@28890|Euryarchaeota,2N9PD@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF432)	-	-	-	ko:K09149	-	-	-	-	ko00000	-	-	-	DUF432
EH3_k127_406850_2	521011.Mpal_0512	2.648e-42	171.0	COG1413@1|root,arCOG02966@2157|Archaea	2157|Archaea	C	PBS lyase HEAT domain protein repeat-containing protein	prp	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
EH3_k127_406850_3	351160.RCIX576	6.232e-11	74.0	COG0642@1|root,COG2202@1|root,arCOG06940@1|root,arCOG06192@2157|Archaea,arCOG06918@2157|Archaea,arCOG06940@2157|Archaea,2Y7UZ@28890|Euryarchaeota,2NBMV@224756|Methanomicrobia	224756|Methanomicrobia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4,PAS_9,Response_reg
EH3_k127_406850_0	323259.Mhun_2437	7.689e-110	361.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,2N98R@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
EH3_k127_4071418_3	593750.Metfor_0452	2.035e-62	218.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,2N9FC@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM NiFe hydrogenase maturation protein HypF	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
EH3_k127_4071418_4	304371.MCP_0067	1.572e-44	167.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,2N9RU@224756|Methanomicrobia	224756|Methanomicrobia	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
EH3_k127_4071418_1	593750.Metfor_0454	4.307e-134	431.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,2N9I6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein, Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
EH3_k127_4071418_0	593750.Metfor_0455	7.759e-289	900.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,2N92E@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
EH3_k127_4071418_5	368407.Memar_1940	1.301e-21	101.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
EH3_k127_4071418_2	593750.Metfor_0457	7.047e-69	239.0	arCOG03479@1|root,arCOG03479@2157|Archaea,2Y0TG@28890|Euryarchaeota,2NB1D@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_41302_1	593750.Metfor_0332	2.406e-81	279.0	arCOG02780@1|root,arCOG02780@2157|Archaea,2XZQI@28890|Euryarchaeota,2N9W5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_41302_0	456442.Mboo_2327	3.758e-97	327.0	COG1693@1|root,arCOG02711@2157|Archaea,2XUUJ@28890|Euryarchaeota,2N94A@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function DUF128	-	-	-	ko:K21640	-	-	-	-	ko00000	-	-	-	DUF128
EH3_k127_41302_2	521011.Mpal_1202	6.411e-60	216.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,2N9ZM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
EH3_k127_41302_3	679926.Mpet_2596	6.809e-46	174.0	COG1361@1|root,arCOG02079@2157|Archaea,2XZ6Z@28890|Euryarchaeota,2NBMG@224756|Methanomicrobia	224756|Methanomicrobia	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_41504_0	521011.Mpal_0544	3.951e-231	721.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,2N99J@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
EH3_k127_41504_1	368407.Memar_1965	1.928e-146	470.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,2N9A4@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
EH3_k127_41504_4	593750.Metfor_1107	2.266e-47	175.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y1IQ@28890|Euryarchaeota,2NA28@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
EH3_k127_41504_8	521011.Mpal_0541	5.674e-17	82.0	COG2157@1|root,arCOG04175@2157|Archaea	2157|Archaea	J	PFAM Ribosomal LX protein	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
EH3_k127_41504_2	456442.Mboo_1882	2.333e-82	279.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,2N9JT@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
EH3_k127_41504_5	521011.Mpal_0539	3.43e-35	136.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,2N9YU@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL31 family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
EH3_k127_41504_7	593750.Metfor_1091	4.048e-18	84.0	COG2167@1|root,arCOG04177@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
EH3_k127_41504_3	593750.Metfor_1090	4.234e-67	233.0	COG2117@1|root,arCOG00037@2157|Archaea,2XTGQ@28890|Euryarchaeota,2N9S4@224756|Methanomicrobia	224756|Methanomicrobia	J	subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain	-	-	-	ko:K07585	-	-	-	-	ko00000	-	-	-	-
EH3_k127_41504_6	323259.Mhun_3016	4.064e-29	117.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
EH3_k127_4411519_1	521011.Mpal_0276	1.013e-109	359.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2N94I@224756|Methanomicrobia	224756|Methanomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
EH3_k127_4411519_3	391623.TERMP_00142	3.824e-23	108.0	COG1669@1|root,COG2361@1|root,arCOG01206@2157|Archaea,arCOG05024@2157|Archaea,2Y0GK@28890|Euryarchaeota,244JN@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86
EH3_k127_4411519_4	368407.Memar_2457	1.509e-11	72.0	arCOG03906@1|root,arCOG03906@2157|Archaea	2157|Archaea	DZ	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3821
EH3_k127_4411519_0	521011.Mpal_2578	2.667e-111	366.0	COG0391@1|root,arCOG04395@2157|Archaea,2XTPP@28890|Euryarchaeota,2N94E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
EH3_k127_4411519_2	521011.Mpal_2577	1.26e-82	282.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
EH3_k127_4432477_0	521011.Mpal_0152	1e-188	601.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
EH3_k127_4432477_1	456442.Mboo_2270	1.383e-88	299.0	COG4021@1|root,arCOG03218@2157|Archaea,2XWU9@28890|Euryarchaeota,2N9I7@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNAHis guanylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thg1,Thg1C
EH3_k127_4432477_3	593750.Metfor_0391	3.022e-31	124.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,2N9Y7@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
EH3_k127_4432477_2	368407.Memar_0400	5.104e-66	229.0	COG0517@1|root,arCOG00607@2157|Archaea,2XTE5@28890|Euryarchaeota,2N998@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
EH3_k127_4433715_2	323259.Mhun_2632	7.41e-124	400.0	COG0516@1|root,arCOG00612@2157|Archaea,2XU40@28890|Euryarchaeota,2NAPF@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
EH3_k127_4433715_3	521011.Mpal_2059	5.543e-63	222.0	COG1777@1|root,arCOG01684@2157|Archaea,2XUMR@28890|Euryarchaeota,2NA1M@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K07721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
EH3_k127_4433715_6	593750.Metfor_1186	2.618e-27	116.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4433715_0	456442.Mboo_1709	0.0	1256.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
EH3_k127_4433715_7	593750.Metfor_1188	3.259e-26	111.0	COG0695@1|root,arCOG02607@2157|Archaea	2157|Archaea	O	COG3634 Alkyl hydroperoxide reductase, large subunit	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Glutaredoxin,Pyr_redox_2
EH3_k127_4433715_5	593750.Metfor_1189	1.719e-49	183.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,2N9X8@224756|Methanomicrobia	224756|Methanomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
EH3_k127_4433715_1	593750.Metfor_1190	6.879e-172	550.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,2N94Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
EH3_k127_4433715_4	323259.Mhun_2762	2.711e-58	216.0	COG3291@1|root,arCOG02510@2157|Archaea	2157|Archaea	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CHB_HEX_C_1,PKD
EH3_k127_44386_2	593750.Metfor_0591	1.348e-54	203.0	COG2314@1|root,COG5635@1|root,arCOG02967@2157|Archaea,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
EH3_k127_44386_1	593750.Metfor_0591	2.176e-83	287.0	COG2314@1|root,COG5635@1|root,arCOG02967@2157|Archaea,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
EH3_k127_44386_4	368407.Memar_0998	1.747e-23	102.0	arCOG03365@1|root,arCOG03365@2157|Archaea,2Y1W5@28890|Euryarchaeota,2NA3V@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_44386_0	593750.Metfor_2114	4.347e-261	813.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
EH3_k127_44386_3	593750.Metfor_2108	2.555e-30	122.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota,2NB58@224756|Methanomicrobia	224756|Methanomicrobia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
EH3_k127_4439228_3	368407.Memar_0521	0.0001124	47.0	COG2426@1|root,arCOG01330@2157|Archaea,2Y4KG@28890|Euryarchaeota	28890|Euryarchaeota	S	Small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
EH3_k127_4439228_2	456442.Mboo_0841	8.168e-49	180.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,2N9UY@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
EH3_k127_4439228_1	694440.JOMF01000005_gene204	4.549e-59	213.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,2N9PZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
EH3_k127_4439228_0	456442.Mboo_0843	9.206e-68	233.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,2N91G@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
EH3_k127_4446687_2	456442.Mboo_1384	4.535e-52	186.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
EH3_k127_4446687_0	456442.Mboo_1383	3.096e-134	434.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2N994@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH3_k127_4446687_3	521011.Mpal_0780	4.495e-46	170.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia	224756|Methanomicrobia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
EH3_k127_4446687_1	368407.Memar_1195	4.048e-117	387.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,2N9II@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	A_deaminase,Amidohydro_1
EH3_k127_4446687_4	593750.Metfor_1829	1.338e-14	74.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y6WB@28890|Euryarchaeota,2NA5T@224756|Methanomicrobia	224756|Methanomicrobia	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
EH3_k127_4452990_2	456442.Mboo_1585	9.36e-35	134.0	arCOG02866@1|root,arCOG02866@2157|Archaea,2Y8JA@28890|Euryarchaeota,2NB6N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4452990_3	593750.Metfor_1628	3.942e-24	102.0	arCOG07469@1|root,arCOG07469@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4452990_0	456442.Mboo_1940	5.052e-106	351.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,2N97C@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
EH3_k127_4452990_5	593750.Metfor_1173	4.398e-18	93.0	COG2881@1|root,arCOG03630@2157|Archaea,2XYDD@28890|Euryarchaeota,2NBAT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
EH3_k127_4452990_1	368407.Memar_1332	1.611e-69	243.0	COG3482@1|root,arCOG05002@2157|Archaea,2XXHR@28890|Euryarchaeota,2N9MU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM TfuA domain protein, core	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
EH3_k127_4452990_4	868131.MSWAN_1943	2.716e-22	100.0	COG1944@1|root,arCOG02882@2157|Archaea,2XUE0@28890|Euryarchaeota,23NW8@183925|Methanobacteria	183925|Methanobacteria	S	methanogenesis marker protein 1	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
EH3_k127_4464806_5	387631.Asulf_00933	5.752e-32	128.0	COG0347@1|root,arCOG02305@2157|Archaea,2XYN5@28890|Euryarchaeota,2475X@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
EH3_k127_4464806_1	521011.Mpal_2711	1.209e-234	732.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,2N98P@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine synthetase, type I	glnA-2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
EH3_k127_4464806_2	521011.Mpal_2710	7.509e-173	548.0	COG0067@1|root,arCOG00095@2157|Archaea,2XUF6@28890|Euryarchaeota,2N91X@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM glutamine amidotransferase, class-II	gltB1	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0665	GATase_2,GATase_6
EH3_k127_4464806_0	1094980.Mpsy_1373	2.405e-273	847.0	COG0069@1|root,arCOG00619@2157|Archaea,2Y7H6@28890|Euryarchaeota,2N95Y@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the glutamate synthase family	gltB2	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0664	Fer4,Fer4_10,Fer4_9,Glu_syn_central,Glu_synthase
EH3_k127_4464806_4	269797.Mbar_A0663	9.546e-103	340.0	COG0070@1|root,arCOG00096@2157|Archaea,2XW01@28890|Euryarchaeota,2N91Z@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM glutamate synthase alpha subunit domain protein	gltB3	-	-	-	-	-	-	-	-	-	-	-	GXGXG
EH3_k127_4464806_3	456442.Mboo_1693	4.316e-135	438.0	COG1035@1|root,arCOG02650@2157|Archaea,2XVXF@28890|Euryarchaeota,2N93J@224756|Methanomicrobia	224756|Methanomicrobia	C	Coenzyme F420 hydrogenase dehydrogenase, beta subunit	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_4,Fer4_6,FrhB_FdhB_C,FrhB_FdhB_N
EH3_k127_4464806_6	323259.Mhun_0597	5.42e-14	81.0	COG3291@1|root,arCOG02559@1|root,arCOG06792@1|root,arCOG02508@2157|Archaea,arCOG02559@2157|Archaea,arCOG06792@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
EH3_k127_4464806_7	335543.Sfum_0903	2.262e-11	70.0	COG4870@1|root,COG4870@2|Bacteria,1NC9B@1224|Proteobacteria,42Z35@68525|delta/epsilon subdivisions,2WTVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Peptidase C1A, papain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
EH3_k127_4504367_1	593750.Metfor_2077	1.723e-120	392.0	COG0306@1|root,arCOG02267@2157|Archaea,2XSUU@28890|Euryarchaeota,2N9TT@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM phosphate transporter	pitA	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
EH3_k127_4504367_3	368407.Memar_1039	2.507e-76	263.0	COG1392@1|root,arCOG02640@2157|Archaea	2157|Archaea	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
EH3_k127_4504367_0	456442.Mboo_0766	3.091e-153	494.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota,2NA3G@224756|Methanomicrobia	224756|Methanomicrobia	H	Nicotinic acid phosphoribosyltransferase	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
EH3_k127_4504367_2	368407.Memar_1088	7.989e-85	287.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,2NA1R@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
EH3_k127_4504367_4	593750.Metfor_2069	6.379e-35	136.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,2N91D@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent	dadD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
EH3_k127_4511468_0	521011.Mpal_1056	1.569e-184	591.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,2N99B@224756|Methanomicrobia	224756|Methanomicrobia	S	hydrophobe amphiphile efflux-3 (HAE3) family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
EH3_k127_4511468_2	368407.Memar_1019	1.414e-150	486.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,2N9BT@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
EH3_k127_4511468_6	323259.Mhun_1102	5.813e-22	99.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,2N9YJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
EH3_k127_4511468_1	593750.Metfor_2124	1.254e-174	556.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,2N98U@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
EH3_k127_4511468_5	368407.Memar_1016	6.707e-41	152.0	COG1745@1|root,arCOG02254@2157|Archaea,2XZ09@28890|Euryarchaeota,2NA4W@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0058	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
EH3_k127_4511468_4	368407.Memar_1015	1.909e-105	348.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT8Z@28890|Euryarchaeota,2NA1D@224756|Methanomicrobia	224756|Methanomicrobia	H	RimK domain protein ATP-grasp	-	-	6.3.2.33	ko:K05844,ko:K15740	ko00790,map00790	-	R09594	RC00064,RC00141	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK
EH3_k127_4511468_3	593750.Metfor_2122	4.082e-117	385.0	COG2423@1|root,arCOG01035@2157|Archaea,2XTTC@28890|Euryarchaeota,2N94J@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate	ala	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
EH3_k127_4525253_1	593750.Metfor_1117	3.317e-147	475.0	COG0422@1|root,arCOG02741@2157|Archaea,2Y2NF@28890|Euryarchaeota,2NAHH@224756|Methanomicrobia	224756|Methanomicrobia	H	Radical SAM ThiC family	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
EH3_k127_4525253_0	521011.Mpal_2254	0.0	1838.0	COG1933@1|root,arCOG03146@1|root,arCOG03146@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,2N91E@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
EH3_k127_4525253_2	456442.Mboo_0125	7.478e-09	58.0	arCOG07476@1|root,arCOG07476@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
EH3_k127_4535137_2	456442.Mboo_0059	1.178e-50	185.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NA6W@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
EH3_k127_4535137_0	323259.Mhun_2931	3.092e-96	322.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2N9I9@224756|Methanomicrobia	28890|Euryarchaeota	E	PFAM ABC transporter related	yvrO-2	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
EH3_k127_4535137_1	323259.Mhun_2930	1.854e-89	307.0	COG1361@1|root,arCOG04400@2157|Archaea,2XZN3@28890|Euryarchaeota,2N9X5@224756|Methanomicrobia	224756|Methanomicrobia	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4574273_3	521011.Mpal_0743	2.438e-34	136.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y879@28890|Euryarchaeota,2N9M1@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
EH3_k127_4574273_2	521011.Mpal_0744	2.792e-112	370.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,2N9EP@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
EH3_k127_4574273_1	593750.Metfor_0530	1.146e-209	657.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,2N90U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
EH3_k127_4574273_4	456442.Mboo_2186	1.165e-24	110.0	arCOG06890@1|root,arCOG06890@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
EH3_k127_4574273_0	593750.Metfor_0532	3.859e-259	816.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,2N92I@224756|Methanomicrobia	224756|Methanomicrobia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
EH3_k127_4608847_2	593750.Metfor_0270	9.307e-86	292.0	COG1361@1|root,arCOG02079@2157|Archaea,2XZ6Z@28890|Euryarchaeota,2NBMG@224756|Methanomicrobia	224756|Methanomicrobia	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4608847_3	456442.Mboo_2325	9.491e-79	271.0	COG2140@1|root,arCOG02602@2157|Archaea,2XWS8@28890|Euryarchaeota,2N9IM@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Glucose-6-phosphate isomerase	gpi	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
EH3_k127_4608847_1	456442.Mboo_2324	1.457e-104	345.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,2N9N9@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
EH3_k127_4608847_0	521011.Mpal_1196	8.894e-142	464.0	COG1226@1|root,arCOG01960@2157|Archaea,2XTQV@28890|Euryarchaeota,2N9KX@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM TrkA-N domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
EH3_k127_4634618_1	693661.Arcve_0696	1.806e-115	375.0	COG0004@1|root,arCOG04397@2157|Archaea,2XTEB@28890|Euryarchaeota,246NZ@183980|Archaeoglobi	183980|Archaeoglobi	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
EH3_k127_4634618_7	323259.Mhun_2505	2.23e-40	151.0	COG0347@1|root,arCOG02305@2157|Archaea,2XYN5@28890|Euryarchaeota	28890|Euryarchaeota	E	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
EH3_k127_4634618_8	521011.Mpal_1539	4.785e-34	136.0	arCOG05300@1|root,arCOG05300@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
EH3_k127_4634618_6	593750.Metfor_1174	6.162e-46	170.0	arCOG05293@1|root,arCOG05293@2157|Archaea	2157|Archaea	G	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4634618_5	593750.Metfor_1336	1.657e-68	240.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
EH3_k127_4634618_0	456442.Mboo_1802	2.127e-121	398.0	COG0463@1|root,arCOG00894@2157|Archaea,2XTEG@28890|Euryarchaeota,2N988@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
EH3_k127_4634618_3	593750.Metfor_0971	1.069e-99	331.0	COG1707@1|root,arCOG00813@2157|Archaea,2XT8A@28890|Euryarchaeota,2NAE8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	ko:K06862	-	-	-	-	ko00000	-	-	-	ACT
EH3_k127_4634618_4	593750.Metfor_0970	2.763e-77	263.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,2N9VK@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
EH3_k127_4634618_2	694440.JOMF01000007_gene907	2.803e-114	376.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,2N92D@224756|Methanomicrobia	224756|Methanomicrobia	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
EH3_k127_4634618_9	456442.Mboo_2060	1.026e-08	57.0	COG1468@1|root,arCOG00793@2157|Archaea,2Y05J@28890|Euryarchaeota,2NA1Y@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
EH3_k127_4647826_0	323259.Mhun_2495	6.193e-87	302.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
EH3_k127_4647826_3	368407.Memar_1748	1.933e-27	117.0	arCOG06067@1|root,arCOG06067@2157|Archaea	2157|Archaea	S	Phosphate-starvation-inducible E	-	-	-	-	-	-	-	-	-	-	-	-	PsiE
EH3_k127_4647826_1	368407.Memar_2117	8.681e-68	236.0	COG4066@1|root,arCOG03215@2157|Archaea,2Y0A8@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0305 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2115
EH3_k127_4647826_2	269797.Mbar_A1308	1.044e-34	135.0	COG2249@1|root,arCOG02577@2157|Archaea,2XXMK@28890|Euryarchaeota,2NAG5@224756|Methanomicrobia	224756|Methanomicrobia	S	Flavodoxin-like fold	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
EH3_k127_4749976_2	368407.Memar_0761	5.323e-35	137.0	COG0836@1|root,arCOG02427@2157|Archaea,2XUHF@28890|Euryarchaeota,2N9CC@224756|Methanomicrobia	224756|Methanomicrobia	M	TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	-	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0229	MannoseP_isomer,NTP_transferase
EH3_k127_4749976_0	1356854.N007_04160	1.066e-103	353.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4H9NK@91061|Bacilli,2783S@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4,PALP
EH3_k127_4749976_1	368407.Memar_1427	9.296e-61	222.0	COG5623@1|root,arCOG04127@2157|Archaea,2XT4Z@28890|Euryarchaeota	28890|Euryarchaeota	A	Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA	-	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
EH3_k127_4765604_1	593750.Metfor_2308	2.685e-102	336.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
EH3_k127_4765604_0	593750.Metfor_2307	4.558e-164	533.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,2N94D@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
EH3_k127_4765604_2	593750.Metfor_2306	1.544e-16	81.0	COG1255@1|root,arCOG04385@2157|Archaea,2XYWU@28890|Euryarchaeota,2NBE6@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0146 family	-	-	-	ko:K09713	-	-	-	-	ko00000	-	-	-	UPF0146
EH3_k127_4769135_0	593750.Metfor_1467	1.144e-244	774.0	COG0249@1|root,arCOG02897@2157|Archaea,2XT0M@28890|Euryarchaeota,2N9EU@224756|Methanomicrobia	224756|Methanomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
EH3_k127_4781553_27	593750.Metfor_1072	2.945e-22	96.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,2N9W4@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
EH3_k127_4781553_26	456442.Mboo_2233	1.055e-26	113.0	COG3364@1|root,arCOG04417@2157|Archaea,2Y0WK@28890|Euryarchaeota,2N9ZI@224756|Methanomicrobia	224756|Methanomicrobia	S	Zn-ribbon containing protein	-	-	-	ko:K07163	-	-	-	-	ko00000	-	-	-	DUF2072
EH3_k127_4781553_24	368407.Memar_1792	1.576e-45	167.0	COG3365@1|root,arCOG04416@2157|Archaea,2XX2F@28890|Euryarchaeota,2N9XF@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2073)	-	-	-	ko:K09743	-	-	-	-	ko00000	-	-	-	DUF2073
EH3_k127_4781553_11	456442.Mboo_2232	4.473e-105	344.0	COG1100@1|root,arCOG00354@2157|Archaea,2XT36@28890|Euryarchaeota,2N9A5@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GTP-binding protein HSR1-related	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	MMR_HSR1
EH3_k127_4781553_17	368407.Memar_1794	2.422e-78	266.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH3_k127_4781553_18	521011.Mpal_2666	2.796e-73	255.0	COG0517@1|root,arCOG00602@2157|Archaea,2XYM5@28890|Euryarchaeota,2N9RH@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH3_k127_4781553_6	593750.Metfor_0471	6.146e-134	433.0	COG0517@1|root,arCOG00600@2157|Archaea,2XX02@28890|Euryarchaeota,2N9I1@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH3_k127_4781553_10	368407.Memar_1797	4.138e-112	368.0	COG0517@1|root,arCOG00600@2157|Archaea,2XXMJ@28890|Euryarchaeota,2N9JW@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
EH3_k127_4781553_12	456442.Mboo_2228	5.359e-105	347.0	COG0517@1|root,arCOG00600@2157|Archaea,2XYA3@28890|Euryarchaeota,2N9Q4@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
EH3_k127_4781553_3	521011.Mpal_2389	1.497e-148	476.0	COG1899@1|root,arCOG04142@2157|Archaea,2XUTF@28890|Euryarchaeota,2N9AF@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-1	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
EH3_k127_4781553_21	521011.Mpal_2388	5.02e-62	217.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
EH3_k127_4781553_16	456442.Mboo_2224	5.064e-81	273.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,2N9QT@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
EH3_k127_4781553_19	593750.Metfor_0484	6.044e-72	244.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,2N9RP@224756|Methanomicrobia	224756|Methanomicrobia	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
EH3_k127_4781553_9	593750.Metfor_0485	2.087e-113	372.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
EH3_k127_4781553_23	456442.Mboo_2221	2.114e-48	177.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2N9UH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
EH3_k127_4781553_22	323259.Mhun_2897	3.111e-59	207.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,2N9Q5@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
EH3_k127_4781553_20	368407.Memar_1806	9.605e-64	220.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2N9S9@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
EH3_k127_4781553_25	323259.Mhun_2895	3.322e-31	124.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,2NA2D@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
EH3_k127_4781553_28	593750.Metfor_0491	7.57e-22	95.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,2NA2R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
EH3_k127_4781553_2	521011.Mpal_2379	1.67e-177	563.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,2NAG2@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
EH3_k127_4781553_13	521011.Mpal_2378	3.54e-104	341.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,2N9BZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
EH3_k127_4781553_14	593750.Metfor_0494	4.254e-104	344.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,2N9H3@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
EH3_k127_4781553_7	368407.Memar_1812	2.786e-130	421.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2N96Q@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
EH3_k127_4781553_15	456442.Mboo_2212	2.504e-84	287.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,2N9PA@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
EH3_k127_4781553_4	593750.Metfor_0497	3.132e-143	462.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,2N94G@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
EH3_k127_4781553_0	456442.Mboo_2210	1.48e-249	780.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
EH3_k127_4781553_8	368407.Memar_1816	7.6e-129	419.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
EH3_k127_4781553_1	593750.Metfor_0500	1.575e-246	773.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,2N9CR@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
EH3_k127_4781553_5	456442.Mboo_2205	8.298e-139	452.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,2N9FG@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ABC-1 domain protein	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
EH3_k127_4786827_2	521011.Mpal_0248	2.752e-59	209.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y12T@28890|Euryarchaeota,2N9VC@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM alkylhydroperoxidase like protein, AhpD family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
EH3_k127_4786827_0	368407.Memar_1858	2.296e-258	810.0	COG1032@1|root,arCOG04984@2157|Archaea,2XUS3@28890|Euryarchaeota,2N97H@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
EH3_k127_4786827_3	456442.Mboo_2445	1.218e-47	175.0	COG1661@1|root,arCOG04212@2157|Archaea,2XZVT@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
EH3_k127_4786827_1	368407.Memar_2464	4.811e-174	563.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,2NA0A@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
EH3_k127_4812155_1	857087.Metme_2112	1.401e-79	275.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,1S2MJ@1236|Gammaproteobacteria,1XF24@135618|Methylococcales	135618|Methylococcales	S	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
EH3_k127_4812155_2	593750.Metfor_1178	8.043e-62	218.0	COG3428@1|root,arCOG04619@2157|Archaea	2157|Archaea	S	membrane	-	-	-	ko:K09167	-	-	-	-	ko00000	-	-	-	bPH_2
EH3_k127_4812155_0	456442.Mboo_1503	8.43e-106	346.0	COG0605@1|root,arCOG04147@2157|Archaea,2XUDD@28890|Euryarchaeota,2NAEN@224756|Methanomicrobia	224756|Methanomicrobia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
EH3_k127_4862893_0	521011.Mpal_0529	2.489e-110	364.0	COG1570@1|root,arCOG04513@2157|Archaea,2XVDP@28890|Euryarchaeota,2NAAC@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM Exonuclease VII large subunit	-	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
EH3_k127_4862893_3	290317.Cpha266_2446	1.014e-07	55.0	COG1722@1|root,COG1722@2|Bacteria,1FEAV@1090|Chlorobi	1090|Chlorobi	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
EH3_k127_4862893_1	593750.Metfor_1080	1.807e-46	172.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,2NB77@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
EH3_k127_4862893_2	593750.Metfor_1079	4.849e-26	111.0	COG1326@1|root,arCOG02680@2157|Archaea,2XUFW@28890|Euryarchaeota,2NA07@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal Zn-finger protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_4899082_4	351160.LRC454	8.528e-99	334.0	arCOG04580@1|root,arCOG04580@2157|Archaea,2XUWY@28890|Euryarchaeota,2NA9J@224756|Methanomicrobia	224756|Methanomicrobia	Q	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
EH3_k127_4899082_1	593750.Metfor_1142	2.165e-139	449.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,2N99Z@224756|Methanomicrobia	224756|Methanomicrobia	F	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
EH3_k127_4899082_7	368407.Memar_1690	1.169e-68	237.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2N9RS@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
EH3_k127_4899082_12	192952.MM_3330	1.428e-19	97.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
EH3_k127_4899082_8	521011.Mpal_2538	9.973e-65	224.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2N9RM@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM cytidyltransferase-related domain	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
EH3_k127_4899082_9	593750.Metfor_1138	1.688e-60	213.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2N9S0@224756|Methanomicrobia	224756|Methanomicrobia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
EH3_k127_4899082_0	368407.Memar_1693	4.145e-195	617.0	COG1148@1|root,arCOG02234@2157|Archaea,2Y7JF@28890|Euryarchaeota,2NBK7@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9,Pyr_redox_2
EH3_k127_4899082_3	456442.Mboo_1840	3.777e-125	411.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,2N95Z@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
EH3_k127_4899082_6	456442.Mboo_1841	1.715e-89	302.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,2N9TJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
EH3_k127_4899082_5	456442.Mboo_1843	2.368e-90	307.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,2N9SR@224756|Methanomicrobia	224756|Methanomicrobia	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
EH3_k127_4899082_11	593750.Metfor_0254	1.056e-23	102.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y4F6@28890|Euryarchaeota,2NB8I@224756|Methanomicrobia	224756|Methanomicrobia	C	ATP synthase subunit C	atpK-2	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
EH3_k127_4899082_2	679926.Mpet_0923	9.812e-138	447.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,2N97Q@224756|Methanomicrobia	224756|Methanomicrobia	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
EH3_k127_4899082_10	521011.Mpal_2546	6.188e-47	170.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,2N946@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
EH3_k127_517789_0	456442.Mboo_1679	0.0	1097.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
EH3_k127_5264674_1	243231.GSU1613	7.684e-14	73.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,43TKZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	endonuclease III	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
EH3_k127_5264674_0	56780.SYN_00402	2.568e-157	510.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2MQYG@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA photolyase	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
EH3_k127_5362639_2	679926.Mpet_1892	1.573e-48	173.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2N94I@224756|Methanomicrobia	224756|Methanomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
EH3_k127_5362639_0	368407.Memar_2152	9.828e-100	333.0	COG0620@1|root,arCOG01876@2157|Archaea,2XUCW@28890|Euryarchaeota,2NAQD@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Methionine synthase, vitamin-B12 independent	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
EH3_k127_5362639_1	456442.Mboo_0101	5.133e-54	197.0	COG0467@1|root,arCOG01175@2157|Archaea,2Y7UD@28890|Euryarchaeota,2NBDD@224756|Methanomicrobia	224756|Methanomicrobia	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
EH3_k127_5362639_3	593750.Metfor_0225	6.669e-33	130.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N9CH@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
EH3_k127_5540452_3	1209989.TepiRe1_0900	1.67e-38	149.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
EH3_k127_5540452_2	593750.Metfor_0521	2.039e-46	173.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y1MD@28890|Euryarchaeota,2NA64@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5540452_1	456442.Mboo_0085	1.529e-233	732.0	COG0247@1|root,COG0479@1|root,arCOG00333@2157|Archaea,arCOG00963@2157|Archaea,2Y85M@28890|Euryarchaeota,2N9EY@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
EH3_k127_5540452_0	521011.Mpal_0402	3.224e-246	770.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinate dehydrogenase fumarate reductase flavoprotein subunit	sdhA	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114	1.3.4.1,1.3.5.1,1.3.5.4	ko:K00239,ko:K18209	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376,M00620	R02164,R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
EH3_k127_5540452_4	456442.Mboo_0087	2.466e-24	104.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,2N91C@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
EH3_k127_5585925_0	313606.M23134_04239	2.968e-82	301.0	COG0642@1|root,COG4251@1|root,COG2205@2|Bacteria,COG4251@2|Bacteria,4NDUQ@976|Bacteroidetes,47PTN@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,PAS_3,PAS_9
EH3_k127_5585925_1	1123269.NX02_28075	3.728e-42	158.0	COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,2U7MF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
EH3_k127_5603561_4	593750.Metfor_1026	2.583e-34	135.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,2NA20@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
EH3_k127_5603561_2	456442.Mboo_1934	5.108e-312	959.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU9Q@28890|Euryarchaeota,2N99Y@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the RNA polymerase beta chain family	rpoB1	-	2.7.7.6	ko:K03045	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3
EH3_k127_5603561_1	456442.Mboo_1933	0.0	1069.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,2N93R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB2	-	2.7.7.6	ko:K03044	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
EH3_k127_5603561_0	593750.Metfor_1029	0.0	1601.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,2N96G@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
EH3_k127_5603561_3	456442.Mboo_1931	7.412e-202	633.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,2N927@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
EH3_k127_5605657_2	1192034.CAP_7054	1.076e-92	309.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the WrbA family	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0771	FMN_red
EH3_k127_5605657_5	368407.Memar_1957	5.501e-59	210.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,2N9RR@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM methyltransferase small	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
EH3_k127_5605657_1	456442.Mboo_1871	1.049e-104	347.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
EH3_k127_5605657_3	593750.Metfor_1114	9.123e-89	296.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,2N9MM@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
EH3_k127_5605657_7	679926.Mpet_1858	1.155e-42	159.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
EH3_k127_5605657_6	521011.Mpal_0547	4.381e-48	173.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,2N9X1@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
EH3_k127_5605657_0	456442.Mboo_1875	2.965e-173	552.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
EH3_k127_5605657_4	368407.Memar_1963	2.34e-72	248.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
EH3_k127_5635640_0	1094980.Mpsy_3038	2.904e-90	303.0	arCOG01637@1|root,arCOG01637@2157|Archaea,2Y1E8@28890|Euryarchaeota,2NA48@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
EH3_k127_5635640_1	444158.MmarC6_0863	6.854e-84	284.0	arCOG03165@1|root,arCOG03165@2157|Archaea,2XXAZ@28890|Euryarchaeota,23QZB@183939|Methanococci	183939|Methanococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5635640_2	593750.Metfor_0693	3.247e-10	66.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,2N985@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
EH3_k127_5649696_0	368407.Memar_0644	6.453e-244	765.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
EH3_k127_5649696_1	368407.Memar_0643	1.134e-215	678.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,2N94C@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
EH3_k127_5649696_2	593750.Metfor_2551	1.595e-201	634.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
EH3_k127_5649696_3	521011.Mpal_0572	1.04e-17	83.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,2N92W@224756|Methanomicrobia	224756|Methanomicrobia	J	sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
EH3_k127_5695712_4	368407.Memar_2211	9.16e-40	150.0	COG0494@1|root,arCOG01073@2157|Archaea	2157|Archaea	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
EH3_k127_5695712_1	593750.Metfor_2840	4.423e-224	699.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,2N9BK@224756|Methanomicrobia	224756|Methanomicrobia	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
EH3_k127_5695712_0	368407.Memar_2213	2.311e-240	754.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
EH3_k127_5695712_3	323259.Mhun_2838	1.181e-120	394.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,2N9E5@224756|Methanomicrobia	224756|Methanomicrobia	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
EH3_k127_5695712_2	521011.Mpal_0290	6.769e-193	609.0	COG0016@1|root,arCOG00411@2157|Archaea,2XUJD@28890|Euryarchaeota,2N9CX@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys)	sepS	-	6.1.1.27	ko:K07587	ko00970,map00970	M00360	R08576	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
EH3_k127_5717476_6	410358.Mlab_1207	5.273e-53	191.0	COG0343@1|root,arCOG00989@2157|Archaea,2XTFH@28890|Euryarchaeota,2N9F2@224756|Methanomicrobia	224756|Methanomicrobia	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
EH3_k127_5717476_4	368407.Memar_1288	1.273e-69	245.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,2N9RQ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
EH3_k127_5717476_3	593750.Metfor_1608	1.188e-71	246.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,2N9J9@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3
EH3_k127_5717476_2	593750.Metfor_1606	4.085e-93	312.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,2N9G7@224756|Methanomicrobia	224756|Methanomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
EH3_k127_5717476_0	368407.Memar_1293	1.187e-211	685.0	COG0826@1|root,arCOG03203@2157|Archaea,2XT7F@28890|Euryarchaeota,2N97J@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
EH3_k127_5717476_5	521011.Mpal_2603	3.631e-53	194.0	COG0169@1|root,arCOG02097@2157|Archaea,2XWH4@28890|Euryarchaeota,2N9XM@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
EH3_k127_5717476_1	368407.Memar_1296	5.186e-147	472.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,2N90S@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
EH3_k127_5718979_0	593750.Metfor_1538	7.299e-195	613.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N92K@224756|Methanomicrobia	224756|Methanomicrobia	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
EH3_k127_5718979_5	456442.Mboo_1462	6.061e-50	184.0	COG1813@1|root,arCOG01863@2157|Archaea,2XYZ0@28890|Euryarchaeota,2N9WA@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
EH3_k127_5718979_2	323259.Mhun_1036	4.207e-137	439.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N93C@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	-	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
EH3_k127_5718979_1	456442.Mboo_1558	1.298e-138	443.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K11645,ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568,R08568	RC00438,RC00439,RC00603,RC00604,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
EH3_k127_5718979_3	456442.Mboo_1559	1.219e-126	412.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
EH3_k127_5718979_4	456442.Mboo_1560	1.897e-93	314.0	COG0722@1|root,arCOG00245@2157|Archaea,2XU8C@28890|Euryarchaeota,2N9HG@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
EH3_k127_5718979_6	521011.Mpal_2607	1.248e-24	105.0	COG0077@1|root,arCOG00255@2157|Archaea,2XTAI@28890|Euryarchaeota,2N9DQ@224756|Methanomicrobia	224756|Methanomicrobia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
EH3_k127_5814970_3	593750.Metfor_0712	8.862e-20	89.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,2N9EE@224756|Methanomicrobia	224756|Methanomicrobia	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
EH3_k127_5814970_1	368407.Memar_1904	1.397e-76	261.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,2N9N5@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
EH3_k127_5814970_2	368407.Memar_1903	4.357e-61	216.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,2N9V1@224756|Methanomicrobia	224756|Methanomicrobia	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
EH3_k127_5814970_0	368407.Memar_1902	6.907e-132	431.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,2N91P@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
EH3_k127_5814970_4	679926.Mpet_0942	2.629e-09	63.0	COG0614@1|root,arCOG02483@1|root,arCOG02483@2157|Archaea,arCOG03611@2157|Archaea	2157|Archaea	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,NHL,PKD,Peptidase_C1,Peptidase_S8
EH3_k127_58163_11	323259.Mhun_0823	2.417e-10	68.0	arCOG10172@1|root,arCOG10172@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_58163_4	456442.Mboo_2440	1.326e-149	479.0	COG4052@1|root,arCOG03226@2157|Archaea,2XTWG@28890|Euryarchaeota,2N9D6@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogenesis marker protein 7	-	-	-	-	-	-	-	-	-	-	-	-	MCR_C
EH3_k127_58163_9	593750.Metfor_0210	1.806e-66	231.0	COG4051@1|root,arCOG04904@2157|Archaea,2Y0XT@28890|Euryarchaeota,2N9XA@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2113)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2113
EH3_k127_58163_1	368407.Memar_2061	1.437e-214	672.0	COG1924@1|root,arCOG02679@2157|Archaea,2XU50@28890|Euryarchaeota,2N92J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
EH3_k127_58163_8	521011.Mpal_0252	1.931e-70	241.0	COG4050@1|root,arCOG04903@2157|Archaea,2XY68@28890|Euryarchaeota,2N9PJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2112
EH3_k127_58163_10	368407.Memar_2063	6.518e-61	213.0	COG4029@1|root,arCOG04901@2157|Archaea,2XZQS@28890|Euryarchaeota,2N9W1@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2102)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2102
EH3_k127_58163_2	456442.Mboo_2435	8.936e-185	591.0	COG4070@1|root,arCOG04900@2157|Archaea,2XU32@28890|Euryarchaeota,2N90Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the UPF0288 family	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_58163_0	593750.Metfor_0215	5.548e-285	882.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
EH3_k127_58163_6	593750.Metfor_0216	3.901e-117	387.0	COG4087@1|root,arCOG01579@2157|Archaea,2XXV0@28890|Euryarchaeota,2N9NS@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iAF692.Mbar_A0708	Hydrolase
EH3_k127_58163_5	456442.Mboo_2432	3.964e-121	399.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2N97Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
EH3_k127_58163_3	521011.Mpal_0258	1.087e-166	532.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
EH3_k127_58163_7	368407.Memar_2160	1.056e-89	299.0	COG0253@1|root,arCOG02255@2157|Archaea,2XUYX@28890|Euryarchaeota,2NAG6@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
EH3_k127_5907098_3	456442.Mboo_1278	3.337e-37	144.0	COG2232@1|root,arCOG01595@2157|Archaea,2XXHX@28890|Euryarchaeota,2N9KN@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
EH3_k127_5907098_1	593750.Metfor_2030	2.973e-74	254.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,2N9MS@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
EH3_k127_5907098_5	456442.Mboo_1276	4.837e-18	86.0	arCOG06936@1|root,arCOG06936@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5907098_4	368407.Memar_1520	9.257e-29	120.0	arCOG05311@1|root,arCOG05311@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_5907098_0	593750.Metfor_2033	4.781e-77	267.0	COG2122@1|root,arCOG04376@2157|Archaea,2XV48@28890|Euryarchaeota,2N9HW@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0280 family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
EH3_k127_5907098_2	456442.Mboo_1212	2.885e-57	214.0	COG4186@1|root,arCOG01154@2157|Archaea,2XYK6@28890|Euryarchaeota,2NB5V@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6054598_3	679926.Mpet_1754	4.367e-06	48.0	COG2242@1|root,arCOG00977@2157|Archaea,2XVKZ@28890|Euryarchaeota,2N9SF@224756|Methanomicrobia	224756|Methanomicrobia	Q	Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7	cbiT	-	2.1.1.196	ko:K02191	ko00860,map00860	-	R05813,R07774	RC00003,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	Methyltransf_18,Methyltransf_25,Methyltransf_31
EH3_k127_6054598_2	1041930.Mtc_1826	3.124e-76	260.0	COG2243@1|root,arCOG00648@2157|Archaea,2XTS5@28890|Euryarchaeota,2N9NT@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
EH3_k127_6054598_0	368407.Memar_0510	4.783e-94	314.0	COG2875@1|root,arCOG00645@2157|Archaea,2XSZA@28890|Euryarchaeota,2N9G2@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0627	TP_methylase
EH3_k127_6054598_1	368407.Memar_0511	2.727e-92	313.0	COG2073@1|root,arCOG00651@2157|Archaea,2XTVD@28890|Euryarchaeota,2N9TZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM cobalamin (vitamin B12) biosynthesis CbiG protein	-	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N
EH3_k127_662336_0	456442.Mboo_2075	8.52e-172	544.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N97Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
EH3_k127_662336_2	410358.Mlab_0608	1.231e-56	203.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2N9GR@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
EH3_k127_662336_1	456442.Mboo_2077	1.54e-163	518.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N918@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
EH3_k127_6638891_0	521011.Mpal_1994	6.988e-113	372.0	COG1571@1|root,arCOG01116@2157|Archaea,2Y2R5@28890|Euryarchaeota,2NA6I@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogenesis marker protein 11	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
EH3_k127_6638891_1	456442.Mboo_1653	1.252e-92	313.0	COG1814@1|root,arCOG01096@2157|Archaea,2Y0T2@28890|Euryarchaeota	28890|Euryarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
EH3_k127_6638891_2	404380.Gbem_2175	9.309e-15	74.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,42VC4@68525|delta/epsilon subdivisions,2WRDM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
EH3_k127_6686794_0	593750.Metfor_2598	4.707e-156	496.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,2N97E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
EH3_k127_6686794_1	368407.Memar_0630	6.055e-129	419.0	COG1571@1|root,arCOG01116@2157|Archaea,2XTUY@28890|Euryarchaeota,2N933@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF1743)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1743
EH3_k127_6686794_2	368407.Memar_0631	1.477e-105	352.0	COG2516@1|root,arCOG00662@2157|Archaea,2Y23P@28890|Euryarchaeota,2NBFM@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH3_k127_6686794_3	593750.Metfor_2594	6.002e-62	217.0	COG4231@1|root,arCOG01612@2157|Archaea,2XWAR@28890|Euryarchaeota,2N95R@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C,TPP_enzyme_N
EH3_k127_6709517_2	521011.Mpal_0976	8.336e-26	107.0	COG1060@1|root,arCOG00657@2157|Archaea,2XT78@28890|Euryarchaeota,2N94M@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofG	-	2.5.1.77	ko:K11780	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
EH3_k127_6709517_1	456442.Mboo_2202	8.325e-91	304.0	COG0152@1|root,arCOG04421@2157|Archaea,2XUKC@28890|Euryarchaeota,2N9F8@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosylaminoimidazolesuccinocarboxamide synthase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
EH3_k127_6709517_3	368407.Memar_1840	1.496e-22	98.0	COG1828@1|root,arCOG04462@2157|Archaea,2XYPB@28890|Euryarchaeota,2NA2T@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
EH3_k127_6709517_0	679926.Mpet_0717	1.358e-106	350.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,2N9HC@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
EH3_k127_6713293_3	521011.Mpal_2646	2.069e-100	334.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,2N925@224756|Methanomicrobia	224756|Methanomicrobia	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
EH3_k127_6713293_8	368407.Memar_2363	1.031e-61	216.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,2N9PT@224756|Methanomicrobia	224756|Methanomicrobia	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
EH3_k127_6713293_0	521011.Mpal_2509	4.8e-209	657.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
EH3_k127_6713293_1	521011.Mpal_2510	2.053e-185	583.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,2N99Q@224756|Methanomicrobia	224756|Methanomicrobia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
EH3_k127_6713293_7	304371.MCP_2746	2.301e-71	250.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,2N9HI@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
EH3_k127_6713293_5	456442.Mboo_0159	4.405e-94	313.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,2N9NG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,MarR
EH3_k127_6713293_4	368407.Memar_2358	1.49e-94	315.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,2N9HB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1524	DHBP_synthase
EH3_k127_6713293_9	593750.Metfor_2782	6.08e-20	91.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	DnaJ,Fer4_13,Fer4_15
EH3_k127_6713293_6	521011.Mpal_0023	2.518e-84	284.0	COG3390@1|root,arCOG02257@2157|Archaea,2XTM4@28890|Euryarchaeota,2N9JC@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
EH3_k127_6713293_2	593750.Metfor_0013	1.515e-172	549.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTYM@28890|Euryarchaeota,2N9GI@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
EH3_k127_6724493_0	593750.Metfor_1620	7.763e-212	665.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N91U@224756|Methanomicrobia	224756|Methanomicrobia	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
EH3_k127_6724493_2	521011.Mpal_0800	1.764e-08	61.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	hsp20b	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
EH3_k127_6724493_1	368407.Memar_1563	5.781e-86	286.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota	28890|Euryarchaeota	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
EH3_k127_6750306_4	368407.Memar_0400	1.628e-94	315.0	COG0517@1|root,arCOG00607@2157|Archaea,2XTE5@28890|Euryarchaeota,2N998@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
EH3_k127_6750306_0	368407.Memar_0399	5.796e-235	737.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
EH3_k127_6750306_5	521011.Mpal_0147	7.448e-81	275.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,2N9JZ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
EH3_k127_6750306_1	456442.Mboo_2275	1.505e-198	631.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,2N951@224756|Methanomicrobia	224756|Methanomicrobia	S	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
EH3_k127_6750306_7	456442.Mboo_0725	7.678e-11	66.0	arCOG03165@1|root,arCOG03165@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6750306_6	555088.DealDRAFT_2075	5.982e-45	169.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6750306_3	593750.Metfor_0368	5.712e-116	380.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUT0@28890|Euryarchaeota,2N9J5@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
EH3_k127_6750306_2	593750.Metfor_0366	9.112e-173	560.0	COG1668@1|root,arCOG04450@2157|Archaea,2XTRJ@28890|Euryarchaeota,2N9IA@224756|Methanomicrobia	224756|Methanomicrobia	C	COG1668 ABC-type Na efflux pump, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
EH3_k127_6758308_1	368407.Memar_1033	2.569e-29	118.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,2N9WI@224756|Methanomicrobia	224756|Methanomicrobia	L	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
EH3_k127_6758308_2	593750.Metfor_0644	3.306e-14	78.0	arCOG12340@1|root,arCOG12340@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6758308_0	521011.Mpal_1958	5.802e-236	751.0	COG0855@1|root,arCOG04535@2157|Archaea,2XTCF@28890|Euryarchaeota,2N965@224756|Methanomicrobia	224756|Methanomicrobia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
EH3_k127_6789329_2	926569.ANT_19760	2.824e-64	226.0	COG2267@1|root,COG2267@2|Bacteria,2G6KF@200795|Chloroflexi	200795|Chloroflexi	I	Alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
EH3_k127_6789329_1	926550.CLDAP_20430	6.212e-67	237.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
EH3_k127_6789329_0	456442.Mboo_1455	2.043e-78	279.0	COG5607@1|root,arCOG05139@2157|Archaea	2157|Archaea	T	CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH,HD,Metallophos_2
EH3_k127_6799004_0	521011.Mpal_2096	1.848e-104	351.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
EH3_k127_6799004_1	368407.Memar_1400	1.313e-43	163.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,2N9U3@224756|Methanomicrobia	224756|Methanomicrobia	J	hydrolase	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
EH3_k127_6799004_2	410358.Mlab_1392	2.987e-25	106.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
EH3_k127_6878462_12	593750.Metfor_2405	4.676e-36	137.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,2N99H@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
EH3_k127_6878462_4	593750.Metfor_2404	7.637e-121	393.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
EH3_k127_6878462_6	456442.Mboo_0734	4.895e-85	284.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
EH3_k127_6878462_5	368407.Memar_0847	5.226e-111	366.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,2N9FT@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
EH3_k127_6878462_7	368407.Memar_0846	5.34e-82	276.0	COG1838@1|root,arCOG04406@2157|Archaea,2XYBR@28890|Euryarchaeota,2NBIN@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, beta	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
EH3_k127_6878462_10	456442.Mboo_0731	1.228e-46	168.0	COG1146@1|root,arCOG00959@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	korD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
EH3_k127_6878462_0	593750.Metfor_2322	8.6e-173	548.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,2N9RY@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
EH3_k127_6878462_2	456442.Mboo_0729	4.262e-144	460.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2NBH3@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
EH3_k127_6878462_8	368407.Memar_0842	9.054e-80	269.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota	28890|Euryarchaeota	C	Oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
EH3_k127_6878462_1	368407.Memar_0841	1.374e-155	498.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
EH3_k127_6878462_3	521011.Mpal_1945	7.695e-144	461.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota	28890|Euryarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
EH3_k127_6878462_13	593750.Metfor_2315	4.546e-26	118.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
EH3_k127_6878462_9	323259.Mhun_0924	5.92e-77	270.0	COG0500@1|root,arCOG03411@2157|Archaea,2XVFA@28890|Euryarchaeota,2NAYR@224756|Methanomicrobia	224756|Methanomicrobia	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
EH3_k127_6878462_11	368407.Memar_0838	1.008e-36	139.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,2N9CD@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
EH3_k127_6879097_4	593750.Metfor_2754	2.014e-15	77.0	COG4843@1|root,arCOG06902@2157|Archaea	593750.Metfor_2754|-	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6879097_0	456442.Mboo_0618	1.307e-121	400.0	arCOG07502@1|root,arCOG07502@2157|Archaea,2Y56F@28890|Euryarchaeota,2NBE8@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6879097_2	368407.Memar_2380	1.528e-75	264.0	COG1408@1|root,arCOG01156@2157|Archaea,2XYFR@28890|Euryarchaeota,2NBCE@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
EH3_k127_6879097_1	593750.Metfor_2574	1.288e-92	308.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,2N9NF@224756|Methanomicrobia	224756|Methanomicrobia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
EH3_k127_6879097_3	368407.Memar_0906	5.701e-18	84.0	arCOG09491@1|root,arCOG09491@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_6895740_2	323259.Mhun_1540	1.08e-09	63.0	arCOG03788@1|root,arCOG03788@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
EH3_k127_6895740_1	679926.Mpet_0316	9.121e-49	182.0	COG2426@1|root,arCOG01330@2157|Archaea,2Y4KG@28890|Euryarchaeota	28890|Euryarchaeota	S	Small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
EH3_k127_6895740_0	456442.Mboo_2259	4.164e-75	258.0	arCOG02290@1|root,arCOG02290@2157|Archaea,2XWJW@28890|Euryarchaeota,2N9PB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
EH3_k127_7017246_4	456442.Mboo_2353	1.976e-23	99.0	arCOG04838@1|root,arCOG04838@2157|Archaea,2Y1E7@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7017246_2	679926.Mpet_2421	2.137e-89	302.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2NAVQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
EH3_k127_7017246_0	368407.Memar_1188	7.391e-287	889.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,2N9G0@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
EH3_k127_7017246_1	368407.Memar_1187	8.777e-211	662.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
EH3_k127_7017246_5	573063.Metin_1131	3.076e-20	96.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,23QYY@183939|Methanococci	183939|Methanococci	C	PFAM molydopterin dinucleotide-binding region	fwdD	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
EH3_k127_7017246_3	368407.Memar_1185	4.425e-27	112.0	COG1145@1|root,arCOG00292@2157|Archaea,2Y7HC@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	-	ko:K11260,ko:K14107	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4
EH3_k127_7050970_2	593750.Metfor_2045	5.907e-70	239.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
EH3_k127_7050970_0	593750.Metfor_2044	4.184e-86	289.0	COG0118@1|root,arCOG00089@2157|Archaea,2XTJ7@28890|Euryarchaeota,2N9N4@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
EH3_k127_7050970_4	323259.Mhun_0041	1.387e-42	166.0	arCOG06913@1|root,arCOG06913@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7050970_3	456442.Mboo_1266	2.228e-56	205.0	COG0640@1|root,arCOG01686@2157|Archaea,2XX9R@28890|Euryarchaeota,2N9WK@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
EH3_k127_7050970_1	456442.Mboo_1267	2.119e-78	266.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
EH3_k127_7299045_4	368407.Memar_1997	1.323e-05	47.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,2N9W4@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
EH3_k127_7299045_0	368407.Memar_1998	5.759e-204	650.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
EH3_k127_7299045_1	593750.Metfor_1073	9.342e-201	636.0	COG1492@1|root,arCOG00105@2157|Archaea,2XT04@28890|Euryarchaeota,2N93Y@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
EH3_k127_7299045_3	368407.Memar_1996	5.202e-19	90.0	arCOG07471@1|root,arCOG07471@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7299045_2	456442.Mboo_1900	1.315e-26	111.0	arCOG05314@1|root,arCOG05314@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7486084_2	368407.Memar_0556	5.062e-47	174.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota	28890|Euryarchaeota	D	Involved in cell shape control	cetZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
EH3_k127_7486084_0	593750.Metfor_2661	3.521e-142	456.0	COG1693@1|root,arCOG02710@2157|Archaea,2XVGZ@28890|Euryarchaeota,2N90G@224756|Methanomicrobia	224756|Methanomicrobia	K	Ribonuclease R winged-helix domain	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
EH3_k127_7486084_1	593750.Metfor_2662	5.482e-50	181.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y071@28890|Euryarchaeota,2N9T7@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM deoxycytidine triphosphate deaminase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
EH3_k127_7723411_1	706587.Desti_4437	7.062e-85	288.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2MQVX@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	PFAM HhH-GPD superfamily base excision DNA repair protein	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
EH3_k127_7723411_2	456442.Mboo_1223	7.613e-59	210.0	COG2241@1|root,arCOG00650@2157|Archaea,2XZ22@28890|Euryarchaeota,2N9VQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit	cbiE	-	2.1.1.289	ko:K03399	ko00860,ko01100,map00860,map01100	-	R05813,R07775	RC00003,RC02052,RC02053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1492	TP_methylase
EH3_k127_7723411_0	368407.Memar_0514	1.184e-112	372.0	COG1903@1|root,arCOG04383@2157|Archaea,2XV53@28890|Euryarchaeota,2N9AY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
EH3_k127_7747468_10	593750.Metfor_2406	1.265e-43	162.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV39@28890|Euryarchaeota,2N923@224756|Methanomicrobia	224756|Methanomicrobia	P	ABC transporter, substrate-binding protein, aliphatic	ssuA	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
EH3_k127_7747468_5	593750.Metfor_2407	1.229e-79	268.0	COG4800@1|root,arCOG04375@2157|Archaea,2XXJS@28890|Euryarchaeota,2N9MB@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
EH3_k127_7747468_2	456442.Mboo_0739	2.817e-183	586.0	COG0165@1|root,arCOG01748@2157|Archaea,2XUWS@28890|Euryarchaeota,2N9AC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
EH3_k127_7747468_3	368407.Memar_0853	4.289e-165	529.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2N97V@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
EH3_k127_7747468_0	368407.Memar_0854	1.155e-263	825.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,2N9BR@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
EH3_k127_7747468_11	593750.Metfor_2411	5.865e-25	107.0	arCOG04481@1|root,arCOG04481@2157|Archaea,2Y0HE@28890|Euryarchaeota,2NA4C@224756|Methanomicrobia	224756|Methanomicrobia	S	Family of unknown function (DUF5350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5350
EH3_k127_7747468_6	456442.Mboo_1660	2.233e-68	238.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota,2NAXX@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
EH3_k127_7747468_8	368407.Memar_0858	7.253e-54	190.0	COG1885@1|root,arCOG02119@2157|Archaea,2XX3M@28890|Euryarchaeota,2N9T5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0212 family	-	-	-	ko:K09731	-	-	-	-	ko00000	-	-	-	DUF555
EH3_k127_7747468_4	456442.Mboo_1658	1.027e-120	394.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,2N9AW@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15,2.7.1.213,2.7.1.73	ko:K00852,ko:K22026	ko00030,ko00230,ko00240,map00030,map00230,map00240	-	R00513,R01051,R01131,R01228,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A2903	PfkB
EH3_k127_7747468_1	521011.Mpal_1087	2.446e-200	642.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
EH3_k127_7747468_9	679926.Mpet_2508	4.265e-51	192.0	arCOG01744@1|root,arCOG01744@2157|Archaea,2Y62D@28890|Euryarchaeota	28890|Euryarchaeota	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
EH3_k127_7747468_7	593750.Metfor_0162	9.863e-60	216.0	arCOG02350@1|root,arCOG03931@1|root,arCOG02350@2157|Archaea,arCOG03931@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,PAS_4,PAS_9,TBPIP
EH3_k127_7763971_2	368407.Memar_0508	8.477e-51	187.0	COG2242@1|root,arCOG00977@2157|Archaea,2XVKZ@28890|Euryarchaeota,2N9SF@224756|Methanomicrobia	224756|Methanomicrobia	Q	Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7	cbiT	-	2.1.1.196	ko:K02191	ko00860,map00860	-	R05813,R07774	RC00003,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	Methyltransf_18,Methyltransf_25,Methyltransf_31
EH3_k127_7763971_1	368407.Memar_0984	1.562e-110	364.0	COG0007@1|root,arCOG00644@2157|Archaea,2XTE1@28890|Euryarchaeota,2N96Z@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
EH3_k127_7763971_0	368407.Memar_0983	2.381e-118	387.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,2N97F@224756|Methanomicrobia	224756|Methanomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1465	Porphobil_deam,Porphobil_deamC
EH3_k127_7763971_3	410358.Mlab_0525	1.296e-22	98.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,2N937@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
EH3_k127_7775463_2	521011.Mpal_0503	7.3e-35	136.0	arCOG05298@1|root,arCOG05298@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7775463_0	593750.Metfor_1895	1.645e-81	274.0	COG0288@1|root,arCOG02860@2157|Archaea,2XUWI@28890|Euryarchaeota,2NB9R@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
EH3_k127_7775463_1	456442.Mboo_1683	4.121e-43	164.0	COG3503@1|root,arCOG04370@2157|Archaea,2XWYK@28890|Euryarchaeota,2N9R6@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
EH3_k127_7785912_1	593750.Metfor_2500	1.6e-226	706.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N9EC@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
EH3_k127_7785912_0	593750.Metfor_2501	2.188e-235	734.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N95A@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
EH3_k127_7785912_4	593750.Metfor_2502	1.628e-62	218.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota,2N9SE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
EH3_k127_7785912_2	456442.Mboo_0707	8.15e-189	599.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia	224756|Methanomicrobia	G	Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
EH3_k127_7785912_3	456442.Mboo_1629	5.15e-135	436.0	COG2899@1|root,arCOG05299@2157|Archaea,2Y4HF@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
EH3_k127_7785912_7	521011.Mpal_2117	2.894e-24	109.0	COG0607@1|root,arCOG02021@2157|Archaea,2XYA6@28890|Euryarchaeota	28890|Euryarchaeota	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
EH3_k127_7785912_5	1365176.N186_00760	1.449e-41	156.0	COG2033@1|root,arCOG02146@2157|Archaea,2XQNQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Desulfoferrodoxin ferrous iron-binding region	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
EH3_k127_7785912_6	521011.Mpal_0470	3.562e-41	153.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYGC@28890|Euryarchaeota,2NAUV@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
EH3_k127_7788207_12	323259.Mhun_1494	2.036e-18	85.0	COG1145@1|root,arCOG04117@2157|Archaea,2Y7JN@28890|Euryarchaeota,2NBK8@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH3_k127_7788207_2	593750.Metfor_1772	3.2e-168	533.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,2N920@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Semialdehyde dehydrogenase NAD - binding	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
EH3_k127_7788207_10	593750.Metfor_1771	8.333e-41	153.0	COG1581@1|root,arCOG01753@2157|Archaea,2Y0UY@28890|Euryarchaeota	28890|Euryarchaeota	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
EH3_k127_7788207_8	456442.Mboo_1401	8.407e-43	160.0	arCOG03480@1|root,arCOG03480@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7788207_3	593750.Metfor_1769	1.548e-138	450.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2N948@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
EH3_k127_7788207_4	593750.Metfor_1768	8.623e-136	436.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,2N93Q@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7788207_0	593750.Metfor_1766	1.025e-207	650.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,2N934@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ-1	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
EH3_k127_7788207_11	593750.Metfor_1765	1.628e-20	92.0	COG3609@1|root,arCOG01009@2157|Archaea,2XZTH@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
EH3_k127_7788207_6	456442.Mboo_1406	1.887e-109	364.0	COG0079@1|root,arCOG04273@2157|Archaea,2XV1E@28890|Euryarchaeota,2N9D3@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,zf-like
EH3_k127_7788207_7	368407.Memar_1446	2.207e-64	228.0	COG2266@1|root,arCOG01871@2157|Archaea,2XZP4@28890|Euryarchaeota,2N9T9@224756|Methanomicrobia	224756|Methanomicrobia	M	MobA-like NTP transferase domain	cobY	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
EH3_k127_7788207_1	521011.Mpal_2149	1.998e-198	626.0	COG1915@1|root,arCOG04422@2157|Archaea,2XTUK@28890|Euryarchaeota,2NAC6@224756|Methanomicrobia	224756|Methanomicrobia	S	LOR SDH bifunctional enzyme conserved	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
EH3_k127_7788207_5	593750.Metfor_1761	1.356e-126	413.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
EH3_k127_7788207_9	593750.Metfor_1760	8.697e-42	164.0	arCOG06913@1|root,arCOG06913@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_78174_6	368407.Memar_1431	4.675e-26	110.0	COG0622@1|root,arCOG01141@2157|Archaea,2XX8V@28890|Euryarchaeota,2NB0G@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
EH3_k127_78174_7	693746.OBV_36450	7.623e-25	119.0	COG4908@1|root,COG4908@2|Bacteria,1TS0H@1239|Firmicutes,24B0M@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,DUF1298
EH3_k127_78174_0	593750.Metfor_0089	4.893e-251	784.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,2N98B@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
EH3_k127_78174_2	521011.Mpal_0661	1.15e-121	401.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota	28890|Euryarchaeota	S	ATP-NAD AcoX kinase	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
EH3_k127_78174_1	323259.Mhun_1785	6.475e-145	475.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,2N9A9@224756|Methanomicrobia	224756|Methanomicrobia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
EH3_k127_78174_5	323259.Mhun_1786	4.098e-75	256.0	COG0512@1|root,arCOG00086@2157|Archaea,2XTES@28890|Euryarchaeota,2N9PV@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
EH3_k127_78174_3	368407.Memar_0073	3.48e-110	367.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,2N9AU@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
EH3_k127_78174_4	323259.Mhun_1788	6.107e-77	269.0	COG0134@1|root,arCOG01088@2157|Archaea,2XTWK@28890|Euryarchaeota,2N9V0@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3621	IGPS
EH3_k127_78174_8	1121937.AUHJ01000005_gene2201	4.9e-08	59.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,466TM@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
EH3_k127_7818076_2	626887.J057_21115	2.632e-07	52.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the carbamate kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iJN746.PP_0999	AA_kinase
EH3_k127_7818076_0	1121946.AUAX01000010_gene3765	4.111e-167	534.0	COG2235@1|root,COG2235@2|Bacteria,2GJTR@201174|Actinobacteria,4D9VS@85008|Micromonosporales	201174|Actinobacteria	E	Amidinotransferase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
EH3_k127_7818076_1	521674.Plim_0927	2.209e-60	213.0	COG2326@1|root,COG2326@2|Bacteria,2IYWN@203682|Planctomycetes	203682|Planctomycetes	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
EH3_k127_7827610_2	593750.Metfor_2231	4.678e-127	410.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
EH3_k127_7827610_5	593750.Metfor_2230	1.501e-52	192.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
EH3_k127_7827610_6	456442.Mboo_0811	3.891e-42	156.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,2N9Y5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
EH3_k127_7827610_8	323259.Mhun_1709	9.097e-28	116.0	COG1645@1|root,arCOG00578@2157|Archaea,2Y1BV@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
EH3_k127_7827610_0	456442.Mboo_0813	7.675e-301	939.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
EH3_k127_7827610_1	323259.Mhun_1707	1.111e-280	873.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
EH3_k127_7827610_3	456442.Mboo_0815	6.999e-98	325.0	arCOG04725@1|root,arCOG04725@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GerE
EH3_k127_7827610_4	368407.Memar_1421	2.735e-97	321.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,2N9ME@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
EH3_k127_7827610_7	593750.Metfor_0002	3.526e-28	117.0	arCOG09576@1|root,arCOG09576@2157|Archaea	2157|Archaea	S	Prokaryotic RING finger family 2	-	-	-	-	-	-	-	-	-	-	-	-	Prok-RING_2
EH3_k127_7827610_11	456442.Mboo_0188	1.414e-13	73.0	arCOG06491@1|root,arCOG06491@2157|Archaea	2157|Archaea	-	-	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	-
EH3_k127_7827610_10	593750.Metfor_0005	1.074e-15	80.0	arCOG06491@1|root,arCOG06491@2157|Archaea	2157|Archaea	-	-	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	-
EH3_k127_7827610_9	323259.Mhun_1826	1.058e-18	92.0	arCOG09574@1|root,arCOG09574@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7827610_12	323259.Mhun_1825	3.962e-10	66.0	arCOG04224@1|root,arCOG04224@2157|Archaea	2157|Archaea	L	defense response to virus	-	-	-	ko:K07061	-	-	-	-	ko00000,ko02048	-	-	-	-
EH3_k127_7839745_4	593750.Metfor_0997	1.623e-53	194.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
EH3_k127_7839745_3	593750.Metfor_0998	8.292e-54	197.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,2N9Z3@224756|Methanomicrobia	224756|Methanomicrobia	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
EH3_k127_7839745_5	456442.Mboo_1953	2.306e-52	185.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,2N9XH@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
EH3_k127_7839745_6	410358.Mlab_1300	1.23e-22	98.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
EH3_k127_7839745_1	323259.Mhun_1128	3.846e-113	370.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,2N93I@224756|Methanomicrobia	224756|Methanomicrobia	J	Translation initiation factor 2 alpha subunit	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
EH3_k127_7839745_8	323259.Mhun_1127	1.68e-14	76.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
EH3_k127_7839745_2	323259.Mhun_1126	1.119e-95	321.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2N9I4@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
EH3_k127_7839745_0	410358.Mlab_1296	4.506e-142	460.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,2N99G@224756|Methanomicrobia	224756|Methanomicrobia	S	PHP C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
EH3_k127_7839745_7	593750.Metfor_1010	7.452e-18	84.0	COG1145@1|root,arCOG00958@2157|Archaea,2Y1CC@28890|Euryarchaeota,2NA30@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
EH3_k127_7849162_0	593750.Metfor_2029	8.043e-92	309.0	COG2232@1|root,arCOG01595@2157|Archaea,2XXHX@28890|Euryarchaeota,2N9KN@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
EH3_k127_7849162_2	456442.Mboo_1279	1.437e-70	247.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2N9WY@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
EH3_k127_7849162_3	456442.Mboo_1280	3.997e-45	168.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
EH3_k127_7849162_1	593750.Metfor_2026	7.552e-72	246.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,2N9NE@224756|Methanomicrobia	224756|Methanomicrobia	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
EH3_k127_7935813_1	368407.Memar_0280	1.138e-42	162.0	arCOG03197@1|root,arCOG03197@2157|Archaea,2XZKC@28890|Euryarchaeota,2N9ZV@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7935813_0	593750.Metfor_0296	6.993e-139	454.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH3_k127_7935813_3	579137.Metvu_1172	1.84e-05	48.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,23Q6F@183939|Methanococci	183939|Methanococci	L	PFAM peptidase U62 modulator of DNA gyrase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
EH3_k127_7964628_6	679926.Mpet_1287	9.663e-73	247.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
EH3_k127_7964628_11	410358.Mlab_1226	5.934e-20	90.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,2NA41@224756|Methanomicrobia	224756|Methanomicrobia	J	structural constituent of ribosome	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
EH3_k127_7964628_7	368407.Memar_1460	9.638e-68	235.0	COG1992@1|root,arCOG00021@2157|Archaea,2Y84Z@28890|Euryarchaeota,2NBNT@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine-phosphate synthase	-	-	2.5.1.3	ko:K21220	ko00730,ko01100,map00730,map01100	-	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	ThiP_synth
EH3_k127_7964628_4	521011.Mpal_0793	4.662e-109	362.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
EH3_k127_7964628_3	456442.Mboo_1392	6.31e-113	368.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2N931@224756|Methanomicrobia	224756|Methanomicrobia	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
EH3_k127_7964628_5	456442.Mboo_1391	2.119e-79	270.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,2N955@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,TRAM
EH3_k127_7964628_2	593750.Metfor_1817	7.393e-128	414.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,2N9FQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
EH3_k127_7964628_8	456442.Mboo_1389	2.885e-59	209.0	arCOG05301@1|root,arCOG05301@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7964628_1	368407.Memar_1467	1.804e-136	445.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,2NB5W@224756|Methanomicrobia	224756|Methanomicrobia	E	peptidase dimerisation domain	argE	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
EH3_k127_7964628_0	593750.Metfor_1674	1.354e-231	726.0	COG1282@1|root,arCOG09400@2157|Archaea,2XV3Y@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM NAD(P) transhydrogenase, beta subunit	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
EH3_k127_7964628_10	593750.Metfor_1673	2.46e-45	166.0	COG3288@1|root,arCOG09401@2157|Archaea,2XZE6@28890|Euryarchaeota	28890|Euryarchaeota	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
EH3_k127_7964628_9	593750.Metfor_1672	5.027e-59	206.0	COG0686@1|root,arCOG06678@2157|Archaea,2XZEG@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM alanine dehydrogenase PNT domain protein	-	GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1,1.6.1.2	ko:K00259,ko:K00324	ko00250,ko00430,ko00760,ko01100,map00250,map00430,map00760,map01100	-	R00112,R00396	RC00001,RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
EH3_k127_7975014_4	593750.Metfor_2308	2.23e-71	244.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
EH3_k127_7975014_2	456442.Mboo_1072	2.559e-81	277.0	COG4002@1|root,arCOG00854@2157|Archaea,2XXS9@28890|Euryarchaeota,2N9HQ@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogen marker protein 4	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_7975014_6	323259.Mhun_0919	2.464e-28	114.0	COG2036@1|root,arCOG02144@2157|Archaea	2157|Archaea	K	transcription factor (CBF NF-Y)	hstA	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
EH3_k127_7975014_7	357808.RoseRS_3392	0.0002279	49.0	COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
EH3_k127_7975014_3	593750.Metfor_2311	3.685e-80	271.0	COG0131@1|root,arCOG04398@2157|Archaea,2XT2K@28890|Euryarchaeota,2N9NB@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1310	IGPD
EH3_k127_7975014_1	456442.Mboo_1066	7.34e-93	311.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,2N949@224756|Methanomicrobia	224756|Methanomicrobia	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
EH3_k127_7975014_0	368407.Memar_0837	4.496e-127	414.0	COG0040@1|root,arCOG02208@2157|Archaea,2XTZ3@28890|Euryarchaeota,2N9AD@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
EH3_k127_7975014_5	521011.Mpal_1744	1.433e-35	136.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,2N9CD@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
EH3_k127_8047202_4	323259.Mhun_1922	7.223e-15	80.0	COG0457@1|root,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
EH3_k127_8047202_3	323259.Mhun_1922	3.031e-17	85.0	COG0457@1|root,arCOG03032@2157|Archaea	2157|Archaea	T	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
EH3_k127_8047202_2	326427.Cagg_1682	1.047e-24	107.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_23570	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_34
EH3_k127_8047202_1	521011.Mpal_0740	1.74e-90	304.0	COG1082@1|root,arCOG01895@2157|Archaea,2XV4X@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
EH3_k127_8047202_0	456442.Mboo_1301	6.776e-154	488.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,2N958@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
EH3_k127_8272661_1	456442.Mboo_0111	7.864e-52	190.0	COG0817@1|root,arCOG06910@2157|Archaea,2Y49H@28890|Euryarchaeota,2NB1G@224756|Methanomicrobia	224756|Methanomicrobia	L	Crossover junction endodeoxyribonuclease RuvC	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
EH3_k127_8272661_2	456442.Mboo_0112	8.943e-44	167.0	COG0632@1|root,arCOG06911@2157|Archaea,2Y4CP@28890|Euryarchaeota,2NAY8@224756|Methanomicrobia	224756|Methanomicrobia	L	RuvA, C-terminal domain	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
EH3_k127_8272661_0	323259.Mhun_0892	4.638e-115	376.0	COG2255@1|root,arCOG00473@2157|Archaea	2157|Archaea	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
EH3_k127_8563_0	456442.Mboo_1253	7.289e-221	703.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
EH3_k127_8563_3	521011.Mpal_1186	3.829e-06	57.0	arCOG07300@1|root,arCOG07300@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8563_1	593750.Metfor_2246	3.238e-37	147.0	COG0417@1|root,arCOG07763@1|root,arCOG00329@2157|Archaea,arCOG07763@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
EH3_k127_8563_2	593750.Metfor_1124	7.478e-09	58.0	arCOG07650@1|root,arCOG07650@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8563_4	584708.Apau_1004	6.495e-05	53.0	2ENZG@1|root,33GKC@2|Bacteria,3TBSZ@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8613187_0	456442.Mboo_1238	1.455e-99	331.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,2N97X@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
EH3_k127_8613187_1	368407.Memar_0979	4.092e-65	228.0	COG1648@1|root,arCOG01044@2157|Archaea,2XWMY@28890|Euryarchaeota,2N9U9@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM siroheme synthase	cysG	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
EH3_k127_8652942_1	593750.Metfor_1230	1.623e-134	438.0	arCOG05290@1|root,arCOG05290@2157|Archaea,2Y58D@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_8652942_0	521460.Athe_2034	2.047e-294	908.0	COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia,42J79@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ferredoxin-dependent glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
EH3_k127_8652942_2	521011.Mpal_2077	6.96e-120	389.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,2N9AE@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
EH3_k127_933_0	456442.Mboo_0144	4.929e-305	942.0	COG1982@1|root,arCOG00092@2157|Archaea	2157|Archaea	E	PFAM Orn Lys Arg decarboxylase major region	-	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
EH3_k127_933_4	521011.Mpal_2482	1.6e-99	330.0	COG0655@1|root,arCOG02572@2157|Archaea,2Y30Q@28890|Euryarchaeota,2NAGE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM NAD(P)H dehydrogenase (quinone)	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
EH3_k127_933_2	593750.Metfor_2082	4.794e-129	421.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2NADX@224756|Methanomicrobia	224756|Methanomicrobia	K	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
EH3_k127_933_5	368407.Memar_2276	9.133e-94	315.0	COG0226@1|root,arCOG00213@2157|Archaea,2XUC6@28890|Euryarchaeota,2NBJP@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
EH3_k127_933_1	593750.Metfor_2080	2.453e-241	762.0	COG0581@1|root,arCOG00168@2157|Archaea,2Y8DS@28890|Euryarchaeota,2N9FR@224756|Methanomicrobia	224756|Methanomicrobia	P	phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
EH3_k127_933_3	593750.Metfor_2079	3.464e-123	399.0	COG1117@1|root,arCOG00231@2157|Archaea,2XTJK@28890|Euryarchaeota,2N93D@224756|Methanomicrobia	224756|Methanomicrobia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
EH3_k127_933_6	593750.Metfor_2078	1.213e-23	102.0	COG0704@1|root,arCOG00232@2157|Archaea,2XUZ9@28890|Euryarchaeota,2N9W2@224756|Methanomicrobia	224756|Methanomicrobia	P	Plays a role in the regulation of phosphate uptake	phoU-2	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
EH3_k127_9413_2	521011.Mpal_1953	2.958e-31	126.0	arCOG03390@1|root,arCOG03390@2157|Archaea,2Y08K@28890|Euryarchaeota,2N9YI@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EH3_k127_9413_0	368407.Memar_1258	9.45e-53	192.0	COG4079@1|root,arCOG03213@2157|Archaea,2XW0G@28890|Euryarchaeota,2NAV2@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2121)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2121
EH3_k127_9413_1	593750.Metfor_2084	3.471e-49	177.0	COG1917@1|root,arCOG02992@2157|Archaea,2XZHW@28890|Euryarchaeota,2NAZU@224756|Methanomicrobia	224756|Methanomicrobia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
## 900 queries scanned
## Total time (seconds): 22.636194705963135
## Rate: 39.76 q/s