## Tue Oct 15 20:21:18 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/GDHHQS1_bin.74.fa -m mmseqs --itype genome -o GDHHQS1_bin.74 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/GDHHQS1_bin.74 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
GDHHQS1_k127_10026009_6	82995.CR62_00675	1.118e-15	85.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1RSE0@1236|Gammaproteobacteria,402C2@613|Serratia	1236|Gammaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_10026009_0	518766.Rmar_1111	3.536e-217	693.0	COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,1FIJF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
GDHHQS1_k127_10026009_1	545695.TREAZ_0022	1.845e-153	494.0	COG3669@1|root,COG3669@2|Bacteria,2J69G@203691|Spirochaetes	203691|Spirochaetes	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
GDHHQS1_k127_10026009_4	395965.Msil_3484	3.549e-36	144.0	COG4113@1|root,COG4113@2|Bacteria,1NEE2@1224|Proteobacteria,2UJ3R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_10026009_5	395965.Msil_3485	5.203e-18	89.0	2A6UU@1|root,30VP8@2|Bacteria,1NQ5B@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10026009_3	1408422.JHYF01000007_gene1302	5.837e-48	182.0	COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,36JNY@31979|Clostridiaceae	186801|Clostridia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
GDHHQS1_k127_10093880_6	511051.CSE_00390	1.128e-129	422.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
GDHHQS1_k127_10093880_0	744872.Spica_2030	3.403e-278	896.0	COG3889@1|root,COG3889@2|Bacteria,2J65D@203691|Spirochaetes	203691|Spirochaetes	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS1_k127_10093880_4	660470.Theba_1947	1.033e-134	438.0	COG0601@1|root,COG0601@2|Bacteria,2GDUZ@200918|Thermotogae	200918|Thermotogae	P	inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS1_k127_10093880_1	660470.Theba_1946	2.966e-158	516.0	COG1173@1|root,COG1173@2|Bacteria,2GE0Y@200918|Thermotogae	200918|Thermotogae	U	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
GDHHQS1_k127_10093880_3	660470.Theba_2418	1.288e-139	473.0	COG0444@1|root,COG0444@2|Bacteria,2GDWH@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_10093880_2	660470.Theba_2419	6.091e-157	505.0	COG4608@1|root,COG4608@2|Bacteria,2GC91@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_10093880_12	1121930.AQXG01000001_gene1108	0.0005988	53.0	2CIUH@1|root,32S8I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10093880_5	383372.Rcas_3626	7.52e-134	443.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
GDHHQS1_k127_10093880_9	552811.Dehly_1029	2.741e-60	213.0	COG1592@1|root,COG4802@1|root,COG1592@2|Bacteria,COG4802@2|Bacteria,2GATJ@200795|Chloroflexi,34DB7@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
GDHHQS1_k127_10093880_11	552811.Dehly_1030	3.783e-22	101.0	COG0695@1|root,COG0695@2|Bacteria,2GAW7@200795|Chloroflexi,34DGN@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
GDHHQS1_k127_10093880_8	1111479.AXAR01000001_gene311	3.249e-64	235.0	COG5482@1|root,COG5482@2|Bacteria,1V3FI@1239|Firmicutes,4HI6C@91061|Bacilli	91061|Bacilli	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2161
GDHHQS1_k127_10093880_7	1304880.JAGB01000001_gene547	4.41e-107	359.0	COG0454@1|root,COG0456@2|Bacteria,1TT30@1239|Firmicutes,24DE0@186801|Clostridia	186801|Clostridia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS1_k127_10093880_10	935557.ATYB01000014_gene3535	5.523e-35	145.0	COG0388@1|root,COG0388@2|Bacteria,1RA15@1224|Proteobacteria,2U1MJ@28211|Alphaproteobacteria,4B72M@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
GDHHQS1_k127_10135618_4	502025.Hoch_1608	8.157e-124	415.0	COG4249@1|root,COG4249@2|Bacteria,1NJ33@1224|Proteobacteria,42PEW@68525|delta/epsilon subdivisions,2WRUQ@28221|Deltaproteobacteria,2Z389@29|Myxococcales	28221|Deltaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
GDHHQS1_k127_10135618_10	404589.Anae109_0876	8.682e-35	146.0	COG5662@1|root,COG5662@2|Bacteria,1Q39S@1224|Proteobacteria,4390Y@68525|delta/epsilon subdivisions,2X465@28221|Deltaproteobacteria,2YYC2@29|Myxococcales	28221|Deltaproteobacteria	K	AntiSigma factor	actD	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10135618_9	378806.STAUR_0585	2.172e-46	173.0	COG1595@1|root,COG1595@2|Bacteria,1RHSF@1224|Proteobacteria,438JV@68525|delta/epsilon subdivisions,2X3UH@28221|Deltaproteobacteria,2YX4W@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	HTH_24,Sigma70_r2,Sigma70_r4_2
GDHHQS1_k127_10135618_0	1499967.BAYZ01000157_gene589	4.237e-202	659.0	COG1486@1|root,COG1486@2|Bacteria,2NQ9I@2323|unclassified Bacteria	2|Bacteria	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22,3.2.1.86	ko:K01222,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603	-	R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_10135618_8	1304880.JAGB01000002_gene2186	7.341e-78	289.0	COG0845@1|root,COG0845@2|Bacteria,1V2R4@1239|Firmicutes,24GQ6@186801|Clostridia	186801|Clostridia	M	Efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
GDHHQS1_k127_10135618_6	1304880.JAGB01000002_gene1929	3.551e-89	299.0	COG1136@1|root,COG1136@2|Bacteria,1TPMF@1239|Firmicutes,24BH4@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_10135618_5	1304880.JAGB01000002_gene1928	2.266e-119	391.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_10135618_7	926550.CLDAP_32200	5.066e-81	289.0	COG0246@1|root,COG0246@2|Bacteria	2|Bacteria	G	mannitol metabolic process	-	-	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
GDHHQS1_k127_10135618_2	573413.Spirs_0059	1.787e-166	554.0	COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
GDHHQS1_k127_10135618_1	160860.XP_007357533.1	5.092e-169	569.0	COG0334@1|root,KOG2250@2759|Eukaryota,390UX@33154|Opisthokonta,3NVNH@4751|Fungi,3UZ5W@5204|Basidiomycota,224JB@155619|Agaricomycetes,3H2CQ@355688|Agaricomycetes incertae sedis	4751|Fungi	E	NAD( )-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate	GDH2	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006103,GO:0006106,GO:0006520,GO:0006536,GO:0006538,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016639,GO:0019551,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051186,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,ELFV_dehydrog
GDHHQS1_k127_10135618_3	909663.KI867150_gene971	1.983e-145	473.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_10333232_2	665571.STHERM_c12020	4.468e-90	311.0	COG0821@1|root,COG0821@2|Bacteria,2J5UT@203691|Spirochaetes	203691|Spirochaetes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
GDHHQS1_k127_10333232_3	665950.HMPREF1025_01232	8.2e-48	179.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,27KP4@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
GDHHQS1_k127_10333232_0	1230342.CTM_21723	2.718e-213	671.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,36DRP@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
GDHHQS1_k127_10333232_1	1499689.CCNN01000006_gene486	6.864e-137	442.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,36DW7@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
GDHHQS1_k127_10432053_8	1499967.BAYZ01000075_gene2069	2.821e-98	327.0	COG0022@1|root,COG0022@2|Bacteria,2NNQZ@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Biotin_lipoyl,Transket_pyr,Transketolase_C
GDHHQS1_k127_10432053_6	1499967.BAYZ01000075_gene2068	1.221e-131	435.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
GDHHQS1_k127_10432053_13	1499967.BAYZ01000075_gene2067	8.423e-35	154.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	ydaG	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx,Pyrid_ox_like
GDHHQS1_k127_10432053_5	504487.JCM19302_2845	4.204e-156	526.0	COG1387@1|root,COG1387@2|Bacteria,4PFQB@976|Bacteroidetes,1I844@117743|Flavobacteriia	976|Bacteroidetes	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10432053_10	573413.Spirs_2677	2.318e-60	226.0	COG2050@1|root,COG2050@2|Bacteria,2JAD0@203691|Spirochaetes	203691|Spirochaetes	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
GDHHQS1_k127_10432053_7	760011.Spico_1861	3.835e-99	341.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,2J58N@203691|Spirochaetes	203691|Spirochaetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
GDHHQS1_k127_10432053_3	795359.TOPB45_1251	1.507e-168	542.0	COG1350@1|root,COG1350@2|Bacteria,2GHCP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
GDHHQS1_k127_10432053_19	1183438.GKIL_3563	1.843e-13	84.0	COG3429@1|root,COG3429@2|Bacteria,1G2UB@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Glucose-6-phosphate dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem,PG_binding_1
GDHHQS1_k127_10432053_4	889378.Spiaf_0198	5.468e-158	525.0	COG0364@1|root,COG0364@2|Bacteria,2J6N0@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
GDHHQS1_k127_10432053_11	665571.STHERM_c19990	2.509e-43	168.0	COG0340@1|root,COG0340@2|Bacteria,2J617@203691|Spirochaetes	203691|Spirochaetes	H	biotin acetyl-CoA-carboxylase ligase	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
GDHHQS1_k127_10432053_16	1123274.KB899410_gene3487	2.634e-27	127.0	COG0560@1|root,COG0560@2|Bacteria,2JB1Y@203691|Spirochaetes	203691|Spirochaetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
GDHHQS1_k127_10432053_0	744872.Spica_0427	9.948e-276	856.0	COG0459@1|root,COG0459@2|Bacteria,2J5CK@203691|Spirochaetes	203691|Spirochaetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
GDHHQS1_k127_10432053_20	889378.Spiaf_0200	9.617e-10	66.0	28WXW@1|root,2ZIX0@2|Bacteria,2J96G@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10432053_17	1047013.AQSP01000138_gene1034	8.476e-25	116.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	4.6.1.1	ko:K01768,ko:K03713,ko:K11923,ko:K13638	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	MerR_1
GDHHQS1_k127_10432053_14	573413.Spirs_3238	9.957e-31	124.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
GDHHQS1_k127_10432053_2	744872.Spica_1832	6.464e-193	619.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
GDHHQS1_k127_10432053_9	1123274.KB899433_gene1343	2.362e-79	291.0	COG0341@1|root,COG0341@2|Bacteria,2J5N7@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
GDHHQS1_k127_10432053_12	342949.PNA2_0923	9.441e-37	152.0	COG2129@1|root,arCOG01145@2157|Archaea,2XW7S@28890|Euryarchaeota,242PU@183968|Thermococci	183968|Thermococci	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
GDHHQS1_k127_10432053_1	665571.STHERM_c01340	1.451e-245	776.0	COG0021@1|root,COG0021@2|Bacteria,2J6KB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
GDHHQS1_k127_10432053_15	357808.RoseRS_2527	3.312e-28	130.0	COG0707@1|root,COG0707@2|Bacteria,2G8GF@200795|Chloroflexi,3768K@32061|Chloroflexia	32061|Chloroflexia	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glycos_transf_1,MGDG_synth
GDHHQS1_k127_10432053_18	207559.Dde_0193	3.413e-16	81.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2M8RR@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
GDHHQS1_k127_10433417_3	1214101.BN159_1654	9.893e-16	78.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
GDHHQS1_k127_10433417_4	1033810.HLPCO_001074	4.653e-10	72.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9,Methyltransf_25
GDHHQS1_k127_10433417_2	485913.Krac_10820	4.612e-23	110.0	COG2045@1|root,COG2045@2|Bacteria	2|Bacteria	H	2-phosphosulfolactate phosphatase activity	-	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
GDHHQS1_k127_10433417_1	1382359.JIAL01000001_gene3042	9.287e-29	132.0	COG1011@1|root,COG1011@2|Bacteria,3Y56D@57723|Acidobacteria,2JJQ6@204432|Acidobacteriia	204432|Acidobacteriia	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
GDHHQS1_k127_10433417_0	1173027.Mic7113_0228	4.584e-31	131.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HHU4@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,dCache_1
GDHHQS1_k127_10480271_12	1122179.KB890435_gene931	1.299e-28	128.0	COG5337@1|root,COG5337@2|Bacteria,4NI4U@976|Bacteroidetes	976|Bacteroidetes	M	COG5337 Spore coat assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH,LTD
GDHHQS1_k127_10480271_10	883.DvMF_3014	5.339e-36	149.0	COG5036@1|root,COG5036@2|Bacteria,1Q515@1224|Proteobacteria,430B2@68525|delta/epsilon subdivisions,2WVUB@28221|Deltaproteobacteria,2MF3Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
GDHHQS1_k127_10480271_11	1499967.BAYZ01000090_gene4947	7.581e-35	147.0	2ATYU@1|root,31JIG@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
GDHHQS1_k127_10480271_7	365044.Pnap_3244	6.769e-63	237.0	COG0265@1|root,COG0265@2|Bacteria,1QWA4@1224|Proteobacteria,2VK6X@28216|Betaproteobacteria,4A9X2@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
GDHHQS1_k127_10480271_2	595537.Varpa_1338	4.602e-145	467.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,4AD31@80864|Comamonadaceae	28216|Betaproteobacteria	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
GDHHQS1_k127_10480271_3	1095769.CAHF01000011_gene2300	2.179e-100	336.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2W98D@28216|Betaproteobacteria,476N1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
GDHHQS1_k127_10480271_4	1095769.CAHF01000011_gene2301	2.636e-90	319.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
GDHHQS1_k127_10480271_14	697303.Thewi_2118	1.031e-19	101.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24IZV@186801|Clostridia,42J2I@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_10480271_6	525904.Tter_2039	1.044e-74	283.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
GDHHQS1_k127_10480271_9	357808.RoseRS_3335	2.203e-39	159.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	-
GDHHQS1_k127_10480271_1	382464.ABSI01000006_gene823	1.249e-157	523.0	COG3170@1|root,COG3170@2|Bacteria,46UPN@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Glycosyl hydrolase family 52	-	-	3.2.1.37	ko:K22268	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH52	-	Glyco_hydro_52
GDHHQS1_k127_10480271_5	357808.RoseRS_3074	3.013e-87	299.0	COG0667@1|root,COG0667@2|Bacteria,2G6BF@200795|Chloroflexi,377XY@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_10480271_8	665942.HMPREF1022_00224	3.363e-51	194.0	COG0679@1|root,COG0679@2|Bacteria,1QKS6@1224|Proteobacteria,435R5@68525|delta/epsilon subdivisions,2X05P@28221|Deltaproteobacteria,2MAPN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	-
GDHHQS1_k127_10480271_0	1293054.HSACCH_01641	7.245e-206	652.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,24ZIP@186801|Clostridia	186801|Clostridia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
GDHHQS1_k127_10480271_13	1293054.HSACCH_01640	2.706e-27	119.0	2ECQ5@1|root,336MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10563889_1	158190.SpiGrapes_2189	4.937e-71	252.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2J8AZ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM competence damage-inducible protein CinA N-terminal domain	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
GDHHQS1_k127_10563889_0	744872.Spica_1604	7.183e-218	687.0	COG1158@1|root,COG1158@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
GDHHQS1_k127_10593516_3	869210.Marky_0743	3.391e-31	133.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Flg_new,LRR_5,PKD
GDHHQS1_k127_10593516_2	749414.SBI_03112	3.205e-36	153.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,2GJ2S@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK
GDHHQS1_k127_10593516_0	697281.Mahau_0817	3.922e-260	823.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,42EN1@68295|Thermoanaerobacterales	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
GDHHQS1_k127_10593516_1	545695.TREAZ_1902	2.643e-127	417.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
GDHHQS1_k127_10593516_4	720554.Clocl_0789	1.097e-09	59.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24IZV@186801|Clostridia,3WP8J@541000|Ruminococcaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_10635614_4	717605.Theco_3925	2.22e-68	234.0	COG1225@1|root,COG1225@2|Bacteria,1V058@1239|Firmicutes,4HE2H@91061|Bacilli,26T9E@186822|Paenibacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
GDHHQS1_k127_10635614_7	1235803.C825_01882	3.623e-23	117.0	COG5434@1|root,COG5434@2|Bacteria,4NIEA@976|Bacteroidetes,2FMVC@200643|Bacteroidia	976|Bacteroidetes	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
GDHHQS1_k127_10635614_1	1121377.KB906399_gene1729	2.101e-147	477.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_10635614_2	1229780.BN381_90106	8.019e-78	275.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,3UWNR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
GDHHQS1_k127_10635614_3	378806.STAUR_3780	9.282e-76	266.0	COG4307@1|root,COG4307@2|Bacteria,1MXES@1224|Proteobacteria,42SJI@68525|delta/epsilon subdivisions,2WPX2@28221|Deltaproteobacteria,2YV2D@29|Myxococcales	28221|Deltaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
GDHHQS1_k127_10635614_6	1191523.MROS_1522	6.331e-56	209.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
GDHHQS1_k127_10635614_0	1116472.MGMO_21c00240	2.855e-210	666.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1XEIR@135618|Methylococcales	135618|Methylococcales	H	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
GDHHQS1_k127_10635614_5	1037409.BJ6T_06440	2.721e-59	211.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2TRMB@28211|Alphaproteobacteria,3JUUA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
GDHHQS1_k127_10635614_9	1123274.KB899407_gene258	3.398e-17	88.0	29IC7@1|root,3059E@2|Bacteria,2JAQH@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10635614_8	1408473.JHXO01000007_gene744	5.825e-19	93.0	COG1120@1|root,COG1120@2|Bacteria	2|Bacteria	HP	ATPase activity	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran,TM1506
GDHHQS1_k127_10657119_0	926569.ANT_05220	1.412e-104	352.0	COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
GDHHQS1_k127_10657119_1	1379698.RBG1_1C00001G1253	4.804e-100	351.0	COG1022@1|root,COG1022@2|Bacteria,2NNTM@2323|unclassified Bacteria	2|Bacteria	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS1_k127_10696041_2	573370.DMR_29630	5.606e-74	269.0	COG0642@1|root,COG4191@1|root,COG5002@1|root,COG0642@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X8BX@28221|Deltaproteobacteria,2MHFZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
GDHHQS1_k127_10696041_0	573370.DMR_35480	1.689e-96	327.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1R4W2@1224|Proteobacteria,43CSC@68525|delta/epsilon subdivisions,2X7ZZ@28221|Deltaproteobacteria,2MHG3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
GDHHQS1_k127_10696041_3	1191523.MROS_1274	2.093e-29	132.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC1	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC,Glutaredoxin
GDHHQS1_k127_10696041_1	1123508.JH636439_gene1391	1.722e-95	344.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_10728413_1	1121920.AUAU01000002_gene2121	1.991e-106	356.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria	57723|Acidobacteria	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
GDHHQS1_k127_10728413_3	545695.TREAZ_2239	1.041e-13	79.0	COG3087@1|root,COG3087@2|Bacteria,2J8S5@203691|Spirochaetes	203691|Spirochaetes	D	PFAM Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
GDHHQS1_k127_10728413_2	1123274.KB899426_gene2791	3.723e-37	148.0	COG0237@1|root,COG0237@2|Bacteria,2J810@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
GDHHQS1_k127_10728413_0	573413.Spirs_3676	6.927e-196	627.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
GDHHQS1_k127_1090105_13	1265505.ATUG01000001_gene3978	5.325e-28	127.0	COG2203@1|root,COG2203@2|Bacteria,1NT6X@1224|Proteobacteria,42XRB@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
GDHHQS1_k127_1090105_15	573413.Spirs_2373	1.545e-20	104.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	hoxI	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	EAL,FliG_C,HATPase_c,HisKA,cNMP_binding
GDHHQS1_k127_1090105_9	1449347.JQLN01000004_gene7281	4.648e-61	225.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,2M34K@2063|Kitasatospora	201174|Actinobacteria	G	pfkB family carbohydrate kinase	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
GDHHQS1_k127_1090105_0	1123274.KB899430_gene1682	0.0	1195.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
GDHHQS1_k127_1090105_5	335543.Sfum_0347	3.961e-75	264.0	COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2MQMZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Protein of unknown function (DUF2400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2400
GDHHQS1_k127_1090105_7	1210884.HG799464_gene10422	6.153e-70	251.0	COG0520@1|root,COG0520@2|Bacteria,2IYSG@203682|Planctomycetes	203682|Planctomycetes	E	PFAM aminotransferase class V	-	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
GDHHQS1_k127_1090105_12	667014.Thein_1317	3.579e-34	150.0	COG1051@1|root,COG1051@2|Bacteria,2GI88@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
GDHHQS1_k127_1090105_2	697281.Mahau_2628	1.068e-113	376.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,42F7F@68295|Thermoanaerobacterales	186801|Clostridia	O	SMART band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
GDHHQS1_k127_1090105_8	1499967.BAYZ01000156_gene563	1.623e-69	248.0	COG1120@1|root,COG1120@2|Bacteria	2|Bacteria	HP	ATPase activity	fhuC	-	3.6.3.28,3.6.3.34	ko:K02013,ko:K02041	ko02010,map02010	M00223,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.9	-	-	ABC_tran
GDHHQS1_k127_1090105_3	1195236.CTER_2031	2.632e-91	320.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24G9G@186801|Clostridia	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_1090105_10	1123274.KB899408_gene3930	5.226e-45	169.0	2B4IF@1|root,31XAC@2|Bacteria,2JAGS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1090105_1	573413.Spirs_0598	2.387e-149	481.0	COG2871@1|root,COG2871@2|Bacteria,2JBKD@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
GDHHQS1_k127_1090105_6	573413.Spirs_0597	5.548e-72	257.0	COG2209@1|root,COG2209@2|Bacteria,2JA3V@203691|Spirochaetes	203691|Spirochaetes	C	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
GDHHQS1_k127_1090105_4	573413.Spirs_0596	4.214e-77	265.0	COG1347@1|root,COG1347@2|Bacteria,2J9XG@203691|Spirochaetes	203691|Spirochaetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
GDHHQS1_k127_1090105_11	1123274.KB899408_gene3926	1.148e-36	150.0	COG2869@1|root,COG2869@2|Bacteria,2JBGM@203691|Spirochaetes	203691|Spirochaetes	C	FMN_bind	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
GDHHQS1_k127_1090105_14	1123274.KB899408_gene3925	1.988e-25	108.0	COG4658@1|root,COG4658@2|Bacteria,2J9NA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the NqrB RnfD family	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
GDHHQS1_k127_10908799_4	744872.Spica_0928	2.905e-15	77.0	COG0568@1|root,COG0568@2|Bacteria,2J5M9@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS1_k127_10908799_2	665571.STHERM_c04550	5.656e-36	147.0	29UU7@1|root,30G6P@2|Bacteria,2JB02@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10908799_3	1123274.KB899428_gene1829	4.998e-34	135.0	COG0234@1|root,COG0234@2|Bacteria,2J8BR@203691|Spirochaetes	203691|Spirochaetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
GDHHQS1_k127_10908799_0	573413.Spirs_1712	6.856e-238	762.0	COG1199@1|root,COG1199@2|Bacteria,2J626@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RadC,ResIII
GDHHQS1_k127_10908799_1	1536773.R70331_21095	3.183e-77	267.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,26TPG@186822|Paenibacillaceae	91061|Bacilli	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
GDHHQS1_k127_10908799_5	1218076.BAYB01000009_gene2051	0.0002093	53.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VQ81@28216|Betaproteobacteria,1KGMV@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
GDHHQS1_k127_10917067_1	110319.CF8_1675	3.046e-91	314.0	COG4974@1|root,COG4974@2|Bacteria,2IGA2@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_10917067_5	1265313.HRUBRA_01348	0.0007259	45.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
GDHHQS1_k127_10917067_3	545695.TREAZ_1859	2.085e-08	59.0	28JJB@1|root,2Z9CE@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10917067_4	589865.DaAHT2_2159	8.939e-07	57.0	COG4930@1|root,COG4930@2|Bacteria,1MWGE@1224|Proteobacteria,42N0V@68525|delta/epsilon subdivisions,2WJ2F@28221|Deltaproteobacteria,2MMS4@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Putative ATP-dependent Lon protease	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	ChlI,Lon_2,Lon_C,MIT_C
GDHHQS1_k127_10917067_0	1501230.ET33_20880	9.585e-163	541.0	COG3408@1|root,COG3408@2|Bacteria,1UXMW@1239|Firmicutes,4IS99@91061|Bacilli,26QZD@186822|Paenibacillaceae	91061|Bacilli	G	Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
GDHHQS1_k127_10917067_2	1267535.KB906767_gene4404	2.326e-33	145.0	2DSF1@1|root,33FW6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10943519_1	935948.KE386494_gene43	1.418e-48	197.0	COG1482@1|root,COG1482@2|Bacteria,1V0PH@1239|Firmicutes,2487K@186801|Clostridia,42F26@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM mannose-6-phosphate isomerase type I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS19425	PMI_typeI
GDHHQS1_k127_10943519_0	1082705.JIBP01000007_gene1301	2.094e-49	192.0	COG0246@1|root,COG0246@2|Bacteria,1MXV8@1224|Proteobacteria,1RPCP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Mannitol-1-Phosphate 5-Dehydrogenase	mtlD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006059,GO:0006066,GO:0008150,GO:0008152,GO:0008926,GO:0009056,GO:0009987,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019400,GO:0019405,GO:0019407,GO:0019592,GO:0019594,GO:0019751,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.17	ko:K00009	ko00051,map00051	-	R02703	RC00085	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_3598,iSbBS512_1146.SbBS512_E4017	Mannitol_dh,Mannitol_dh_C
GDHHQS1_k127_10975109_1	1122223.KB890700_gene1996	3.422e-68	241.0	COG0687@1|root,COG0687@2|Bacteria,1WIRI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Spermidine putrescine-binding periplasmic protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
GDHHQS1_k127_10975109_0	314254.OA2633_11585	2.564e-136	456.0	COG0520@1|root,COG0520@2|Bacteria,1N124@1224|Proteobacteria,2TZXB@28211|Alphaproteobacteria,43ZHD@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
GDHHQS1_k127_10975109_2	1370120.AUWR01000008_gene472	5.711e-53	202.0	COG0604@1|root,COG0604@2|Bacteria,2GK40@201174|Actinobacteria,233XP@1762|Mycobacteriaceae	201174|Actinobacteria	C	Thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle	fadB5	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
GDHHQS1_k127_10975109_3	56110.Oscil6304_4900	3.952e-35	138.0	2DM6P@1|root,31XVD@2|Bacteria,1GQBD@1117|Cyanobacteria,1HCJS@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10982296_2	243275.TDE_1085	3.537e-06	50.0	COG0773@1|root,COG0773@2|Bacteria,2J5DC@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
GDHHQS1_k127_10982296_1	573413.Spirs_1518	5.27e-60	222.0	2DRY6@1|root,33DN5@2|Bacteria,2JB74@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_10982296_0	573413.Spirs_1516	1.317e-108	366.0	COG0621@1|root,COG0621@2|Bacteria,2J5SB@203691|Spirochaetes	203691|Spirochaetes	J	Radical SAM methylthiotransferase, MiaB RimO family	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
GDHHQS1_k127_11016224_3	596151.DesfrDRAFT_1958	4.929e-133	440.0	COG0624@1|root,COG0624@2|Bacteria,1QA8S@1224|Proteobacteria,42NAJ@68525|delta/epsilon subdivisions,2X5JD@28221|Deltaproteobacteria,2MG8U@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
GDHHQS1_k127_11016224_8	889378.Spiaf_1819	1.078e-55	216.0	2F4TS@1|root,33XG8@2|Bacteria,2J5NM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
GDHHQS1_k127_11016224_1	744872.Spica_0750	1.312e-184	597.0	COG0488@1|root,COG0488@2|Bacteria,2J5AN@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
GDHHQS1_k127_11016224_4	1123274.KB899409_gene442	6.942e-108	372.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS1_k127_11016224_6	479434.Sthe_1355	3.961e-89	310.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,27XV0@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
GDHHQS1_k127_11016224_2	744872.Spica_0421	3.886e-138	454.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
GDHHQS1_k127_11016224_7	665571.STHERM_c19290	1.381e-67	247.0	COG2890@1|root,COG2890@2|Bacteria,2J7VJ@203691|Spirochaetes	203691|Spirochaetes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
GDHHQS1_k127_11016224_0	889378.Spiaf_1825	1.246e-245	780.0	COG0317@1|root,COG0317@2|Bacteria,2J5JE@203691|Spirochaetes	203691|Spirochaetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
GDHHQS1_k127_11016224_5	889378.Spiaf_2458	5.222e-93	321.0	2EJFP@1|root,33D6N@2|Bacteria,2J5TW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
GDHHQS1_k127_11037193_2	665571.STHERM_c04580	2.982e-13	83.0	COG2231@1|root,COG2231@2|Bacteria	2|Bacteria	L	endonuclease III	magIII	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
GDHHQS1_k127_11037193_0	573413.Spirs_3573	1.884e-142	480.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	cutE	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
GDHHQS1_k127_11037193_1	665571.STHERM_c14370	1.567e-130	424.0	COG0162@1|root,COG0162@2|Bacteria,2J5ZS@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
GDHHQS1_k127_11053431_2	765913.ThidrDRAFT_1972	1.459e-66	259.0	COG0642@1|root,COG3614@1|root,COG4251@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG3614@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WVYT@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
GDHHQS1_k127_11053431_1	1449063.JMLS01000003_gene1914	1.278e-143	479.0	COG1073@1|root,COG1073@2|Bacteria,1TYA4@1239|Firmicutes,4I7DS@91061|Bacilli,26WH4@186822|Paenibacillaceae	91061|Bacilli	S	Acetyl xylan esterase (AXE1)	-	-	-	-	-	-	-	-	-	-	-	-	AXE1
GDHHQS1_k127_11053431_0	1499967.BAYZ01000157_gene589	4.559e-188	594.0	COG1486@1|root,COG1486@2|Bacteria,2NQ9I@2323|unclassified Bacteria	2|Bacteria	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22,3.2.1.86	ko:K01222,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603	-	R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_11093638_6	665571.STHERM_c15820	3.199e-76	264.0	COG0337@1|root,COG0337@2|Bacteria,2J69J@203691|Spirochaetes	203691|Spirochaetes	H	3-dehydroquinate synthase	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
GDHHQS1_k127_11093638_10	744872.Spica_0136	2.076e-25	121.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
GDHHQS1_k127_11093638_0	665571.STHERM_c15810	5.784e-288	906.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
GDHHQS1_k127_11093638_3	502025.Hoch_5472	5.908e-112	376.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YYM7@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the ClpX chaperone family	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small
GDHHQS1_k127_11093638_9	525904.Tter_1913	9.168e-28	124.0	COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M28	ywaD	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
GDHHQS1_k127_11093638_1	1480694.DC28_14775	3.284e-154	505.0	COG0124@1|root,COG0124@2|Bacteria,2J5DX@203691|Spirochaetes	203691|Spirochaetes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
GDHHQS1_k127_11093638_4	483219.LILAB_26910	1.561e-85	298.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11093638_7	889378.Spiaf_2023	7.55e-75	267.0	COG0617@1|root,COG0617@2|Bacteria,2J5VH@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
GDHHQS1_k127_11093638_5	1307761.L21SP2_0814	2.979e-81	287.0	COG0457@1|root,COG0457@2|Bacteria,2J6MJ@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
GDHHQS1_k127_11093638_8	1123274.KB899415_gene2516	2e-54	200.0	COG0714@1|root,COG1302@1|root,COG0714@2|Bacteria,COG1302@2|Bacteria,2J6I6@203691|Spirochaetes	203691|Spirochaetes	S	Associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11093638_2	1047013.AQSP01000138_gene1035	6.797e-141	462.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
GDHHQS1_k127_11095383_7	512565.AMIS_41550	0.0004688	51.0	COG0204@1|root,COG0204@2|Bacteria,2IB9T@201174|Actinobacteria,4D995@85008|Micromonosporales	201174|Actinobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
GDHHQS1_k127_11095383_5	649747.HMPREF0083_06221	3.827e-27	114.0	COG1733@1|root,COG1733@2|Bacteria,1VBI7@1239|Firmicutes,4HKBR@91061|Bacilli,26Y68@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	yodB	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	HxlR
GDHHQS1_k127_11095383_3	1123368.AUIS01000003_gene1806	3.347e-53	194.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,LUD_dom,SnoaL_3,SnoaL_4
GDHHQS1_k127_11095383_4	545694.TREPR_1653	4.699e-40	154.0	COG0760@1|root,COG0760@2|Bacteria,2J7Z8@203691|Spirochaetes	203691|Spirochaetes	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
GDHHQS1_k127_11095383_0	448385.sce9160	3.958e-122	402.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
GDHHQS1_k127_11095383_1	525897.Dbac_2003	2.26e-103	345.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,42PMI@68525|delta/epsilon subdivisions,2WM2W@28221|Deltaproteobacteria,2MA56@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
GDHHQS1_k127_11095383_2	504728.K649_07925	1.026e-84	299.0	COG1177@1|root,COG1177@2|Bacteria,1WICS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type spermidine putrescine transport system, permease component II	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
GDHHQS1_k127_11095383_6	525282.HMPREF0391_11302	6.607e-16	81.0	COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia,22H59@1570339|Peptoniphilaceae	186801|Clostridia	P	ABC transporter, solute-binding protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1,SBP_bac_6,SBP_bac_8
GDHHQS1_k127_11105670_3	1123274.KB899410_gene3550	1.791e-42	168.0	COG2204@1|root,COG2204@2|Bacteria,2JAI3@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
GDHHQS1_k127_11105670_0	1123274.KB899410_gene3549	5.577e-68	237.0	COG0745@1|root,COG0745@2|Bacteria,2J7DK@203691|Spirochaetes	203691|Spirochaetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
GDHHQS1_k127_11105670_4	744872.Spica_2162	5.816e-29	126.0	COG2454@1|root,COG2454@2|Bacteria,2JADQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
GDHHQS1_k127_11105670_6	573413.Spirs_3751	4.615e-19	96.0	COG2137@1|root,COG2137@2|Bacteria,2J7QC@203691|Spirochaetes	203691|Spirochaetes	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
GDHHQS1_k127_11105670_2	573413.Spirs_3752	1.252e-47	177.0	COG0103@1|root,COG0103@2|Bacteria,2J8A0@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
GDHHQS1_k127_11105670_1	545694.TREPR_2981	1e-54	195.0	COG0102@1|root,COG0102@2|Bacteria,2J7C1@203691|Spirochaetes	203691|Spirochaetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
GDHHQS1_k127_11105670_7	1480694.DC28_10050	7.198e-19	88.0	28WC9@1|root,2ZICM@2|Bacteria,2J8XW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11105670_8	247490.KSU1_B0122	1.36e-12	70.0	2DU2S@1|root,33NPR@2|Bacteria,2J4AF@203682|Planctomycetes	203682|Planctomycetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
GDHHQS1_k127_11105670_5	861299.J421_3607	1.536e-26	125.0	COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria,1ZSQV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso,PIG-L
GDHHQS1_k127_11105670_9	1321815.HMPREF9193_01217	5.841e-08	56.0	294UB@1|root,2ZS7H@2|Bacteria,2J8RW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11143379_4	530564.Psta_2317	1.458e-60	222.0	COG1028@1|root,COG1028@2|Bacteria,2IX1Z@203682|Planctomycetes	203682|Planctomycetes	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS1_k127_11143379_8	1123274.KB899417_gene2080	1.078e-43	164.0	COG2606@1|root,COG2606@2|Bacteria,2J8HJ@203691|Spirochaetes	203691|Spirochaetes	S	YbaK prolyl-tRNA synthetase associated region	ybaK	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
GDHHQS1_k127_11143379_1	744872.Spica_0753	3.606e-99	329.0	COG0807@1|root,COG0807@2|Bacteria,2J9XB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	-	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
GDHHQS1_k127_11143379_0	794903.OPIT5_13320	6.914e-186	589.0	COG0436@1|root,COG0436@2|Bacteria,46TMR@74201|Verrucomicrobia,3K74G@414999|Opitutae	414999|Opitutae	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS1_k127_11143379_6	743719.PaelaDRAFT_2982	5.875e-55	198.0	COG2318@1|root,COG2318@2|Bacteria,1V2BI@1239|Firmicutes,4HF8B@91061|Bacilli,26XPE@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the metal hydrolase YfiT family	yfiT	-	-	-	-	-	-	-	-	-	-	-	DinB_2
GDHHQS1_k127_11143379_7	927658.AJUM01000047_gene2754	1.553e-53	196.0	COG1335@1|root,COG1335@2|Bacteria,4NS3S@976|Bacteroidetes,2FXXN@200643|Bacteroidia,3XK20@558415|Marinilabiliaceae	976|Bacteroidetes	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
GDHHQS1_k127_11143379_2	994573.T472_0208690	1.063e-74	263.0	COG0697@1|root,COG0697@2|Bacteria,1V1H0@1239|Firmicutes,24BBW@186801|Clostridia,36DKH@31979|Clostridiaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS1_k127_11143379_5	635013.TherJR_1189	3.817e-56	208.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,2631B@186807|Peptococcaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS1_k127_11143379_3	1121011.AUCB01000012_gene1643	9.827e-62	217.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,1HX5F@117743|Flavobacteriia,23H18@178469|Arenibacter	976|Bacteroidetes	O	Peptide methionine sulfoxide reductase	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
GDHHQS1_k127_11143379_9	926569.ANT_05220	1.141e-14	75.0	COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
GDHHQS1_k127_11146788_1	1480694.DC28_12175	3.497e-150	486.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM-2	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
GDHHQS1_k127_11146788_0	665571.STHERM_c02830	9.794e-247	766.0	COG0174@1|root,COG0174@2|Bacteria,2J6JS@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
GDHHQS1_k127_11194906_9	391037.Sare_3026	6.689e-05	49.0	COG2161@1|root,COG2161@2|Bacteria,2HWXR@201174|Actinobacteria,4DKNB@85008|Micromonosporales	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
GDHHQS1_k127_11194906_10	211165.AJLN01000047_gene6129	0.0002561	51.0	COG4113@1|root,COG4113@2|Bacteria,1GDRC@1117|Cyanobacteria,1JMJ1@1189|Stigonemataceae	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_11194906_2	404589.Anae109_1511	1.99e-103	351.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2Z11I@29|Myxococcales	28221|Deltaproteobacteria	M	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
GDHHQS1_k127_11194906_4	697281.Mahau_1339	2.826e-66	241.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_11194906_0	1499967.BAYZ01000077_gene870	8.259e-205	647.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
GDHHQS1_k127_11194906_1	1128421.JAGA01000001_gene2222	1.359e-168	534.0	COG1082@1|root,COG1082@2|Bacteria,2NQCG@2323|unclassified Bacteria	2|Bacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
GDHHQS1_k127_11194906_7	255470.cbdbA1472	8.776e-33	132.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11194906_8	1162668.LFE_0693	9.443e-17	93.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
GDHHQS1_k127_11194906_5	1536773.R70331_07180	2.647e-63	233.0	COG1063@1|root,COG1063@2|Bacteria,1U5I6@1239|Firmicutes,4HT2Q@91061|Bacilli,272WN@186822|Paenibacillaceae	91061|Bacilli	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
GDHHQS1_k127_11194906_3	1123508.JH636439_gene1346	2.851e-98	331.0	COG0667@1|root,COG0667@2|Bacteria,2IYHD@203682|Planctomycetes	203682|Planctomycetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_11194906_6	889378.Spiaf_0743	1.602e-35	139.0	2C8AB@1|root,2ZW6G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11252824_4	536227.CcarbDRAFT_3956	1.66e-05	49.0	COG1410@1|root,COG1410@2|Bacteria,1V5ZS@1239|Firmicutes,24I4A@186801|Clostridia,36NGX@31979|Clostridiaceae	186801|Clostridia	E	PFAM Vitamin B12 dependent methionine synthase, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	Met_synt_B12
GDHHQS1_k127_11252824_0	1195236.CTER_3181	6.93e-236	741.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3WGWJ@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
GDHHQS1_k127_11252824_2	555779.Dthio_PD3056	4.045e-26	115.0	COG2062@1|root,COG2062@2|Bacteria,1RGWQ@1224|Proteobacteria,42SEE@68525|delta/epsilon subdivisions,2WPM2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Phosphoglycerate mutase	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
GDHHQS1_k127_11252824_1	1035308.AQYY01000002_gene304	2.62e-47	181.0	COG0153@1|root,COG0153@2|Bacteria	2|Bacteria	G	galactokinase activity	galK	-	2.7.1.157,2.7.1.6	ko:K00849,ko:K18674	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
GDHHQS1_k127_11289909_1	1125725.HMPREF1325_0106	1.074e-125	409.0	2ANAZ@1|root,31D98@2|Bacteria,2JA00@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_11289909_0	1125699.HMPREF9194_00530	1.863e-211	666.0	COG0747@1|root,COG0747@2|Bacteria,2J9WD@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
GDHHQS1_k127_11411742_4	1480694.DC28_00545	1.333e-81	283.0	2BFJ7@1|root,329D7@2|Bacteria,2J651@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	flaA	-	-	-	-	-	-	-	-	-	-	-	FlaA
GDHHQS1_k127_11411742_10	906968.Trebr_1835	6.496e-10	68.0	2DF9V@1|root,2ZR1A@2|Bacteria,2J8C8@203691|Spirochaetes	203691|Spirochaetes	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
GDHHQS1_k127_11411742_5	906968.Trebr_1836	7.296e-79	275.0	COG0860@1|root,COG0860@2|Bacteria,2J5PE@203691|Spirochaetes	203691|Spirochaetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1
GDHHQS1_k127_11411742_0	665571.STHERM_c09640	2.89e-131	458.0	COG1181@1|root,COG1181@2|Bacteria,2J5KK@203691|Spirochaetes	203691|Spirochaetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4
GDHHQS1_k127_11411742_3	889378.Spiaf_1676	1.347e-94	332.0	COG2227@1|root,COG2227@2|Bacteria,2JBIU@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase domain	ubiG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
GDHHQS1_k127_11411742_8	1123274.KB899412_gene1455	1.253e-44	170.0	COG1861@1|root,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
GDHHQS1_k127_11411742_7	889378.Spiaf_1678	4.077e-59	221.0	COG1216@1|root,COG1216@2|Bacteria,2J6ET@203691|Spirochaetes	203691|Spirochaetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11411742_1	744872.Spica_1637	2.702e-126	422.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
GDHHQS1_k127_11411742_2	573413.Spirs_1343	3.308e-126	417.0	COG1570@1|root,COG1570@2|Bacteria,2J5ED@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
GDHHQS1_k127_11411742_11	485915.Dret_1760	5.057e-05	48.0	COG1722@1|root,COG1722@2|Bacteria,1PZUE@1224|Proteobacteria,43334@68525|delta/epsilon subdivisions,2WYAA@28221|Deltaproteobacteria,2MD2Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
GDHHQS1_k127_11411742_9	545695.TREAZ_0763	3.338e-33	133.0	COG1430@1|root,COG1430@2|Bacteria,2J80F@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
GDHHQS1_k127_11411742_6	1123354.AUDR01000013_gene740	6.95e-63	226.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria	28216|Betaproteobacteria	J	SMART PUA domain containing protein	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
GDHHQS1_k127_11481071_0	1191523.MROS_2212	9.426e-99	330.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_11481071_1	880073.Calab_1764	4.618e-74	270.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_11481071_2	1121033.AUCF01000027_gene2780	2.069e-51	203.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVJ@204441|Rhodospirillales	204441|Rhodospirillales	T	transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9
GDHHQS1_k127_11481214_2	445971.ANASTE_00826	1.234e-49	184.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,25ZNZ@186806|Eubacteriaceae	186801|Clostridia	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
GDHHQS1_k127_11481214_1	1499967.BAYZ01000067_gene6041	2.354e-74	261.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
GDHHQS1_k127_11481214_0	1499967.BAYZ01000067_gene6042	1.177e-185	608.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_1151706_1	1121013.P873_08560	6.874e-08	60.0	COG0265@1|root,COG0265@2|Bacteria,1R61I@1224|Proteobacteria	1224|Proteobacteria	O	peptidase S1 and S6 chymotrypsin Hap	-	-	3.4.21.50	ko:K01337	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Trypsin,Trypsin_2
GDHHQS1_k127_1151706_0	1163617.SCD_n01943	1.266e-111	369.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria	28216|Betaproteobacteria	BQ	histone deacetylase	hda	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
GDHHQS1_k127_11536635_5	1122138.AQUZ01000006_gene1267	1.837e-13	75.0	COG1737@1|root,COG1737@2|Bacteria,2HY2W@201174|Actinobacteria,4DNGK@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator, RpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
GDHHQS1_k127_11536635_2	1123511.KB905880_gene2444	2.176e-77	277.0	COG1850@1|root,COG1850@2|Bacteria,1TSZQ@1239|Firmicutes,4H3SI@909932|Negativicutes	1239|Firmicutes	G	ribulose- bisphosphate carboxylase large chain	mtnW	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009853,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016984,GO:0043094,GO:0044237	5.3.2.5	ko:K08965	ko00270,ko01100,map00270,map01100	M00034	R07393	RC02421	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
GDHHQS1_k127_11536635_3	794903.OPIT5_12865	3.298e-76	267.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_11536635_4	469383.Cwoe_2774	1.584e-38	165.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4CPDS@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
GDHHQS1_k127_11536635_1	926550.CLDAP_29470	1.538e-97	332.0	COG1071@1|root,COG1071@2|Bacteria,2G5PA@200795|Chloroflexi	200795|Chloroflexi	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
GDHHQS1_k127_11536635_0	553973.CLOHYLEM_05689	2.863e-115	396.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,221X6@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_11576633_9	1304880.JAGB01000002_gene2035	0.0001482	51.0	COG2211@1|root,COG2211@2|Bacteria,1URUG@1239|Firmicutes,248SK@186801|Clostridia	186801|Clostridia	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_11576633_7	941449.dsx2_0394	9.605e-32	131.0	COG3467@1|root,COG3467@2|Bacteria,1N4RH@1224|Proteobacteria,42TKQ@68525|delta/epsilon subdivisions,2WQ06@28221|Deltaproteobacteria,2MBAF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Pyridoxamine 5'-phosphate oxidase-related	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
GDHHQS1_k127_11576633_8	66874.JOFS01000020_gene5595	5.857e-09	58.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS,Methyltransf_25
GDHHQS1_k127_11576633_5	1121413.JMKT01000014_gene2447	2.828e-55	210.0	COG2230@1|root,COG2230@2|Bacteria,1R1J6@1224|Proteobacteria,43DEG@68525|delta/epsilon subdivisions,2X8KD@28221|Deltaproteobacteria,2MHIT@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
GDHHQS1_k127_11576633_1	556261.HMPREF0240_03852	1.591e-134	439.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,36QW9@31979|Clostridiaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_11576633_4	1121918.ARWE01000001_gene393	9.114e-78	273.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,42MQN@68525|delta/epsilon subdivisions,2WRJ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1,HTH_18,Methyltransf_1N
GDHHQS1_k127_11576633_3	573413.Spirs_2239	1.087e-81	295.0	COG0572@1|root,COG0572@2|Bacteria,2J6XC@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
GDHHQS1_k127_11576633_0	886293.Sinac_7380	3.019e-207	651.0	COG0141@1|root,COG0141@2|Bacteria,2IXQ3@203682|Planctomycetes	2|Bacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD2	-	1.1.1.308	ko:K15509	-	-	-	-	ko00000,ko01000	-	-	-	Histidinol_dh
GDHHQS1_k127_11576633_2	794903.OPIT5_12840	1.861e-93	330.0	COG0673@1|root,COG0673@2|Bacteria,46WEJ@74201|Verrucomicrobia,3K8W2@414999|Opitutae	414999|Opitutae	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_11576633_6	99598.Cal7507_0048	1.4e-32	147.0	COG2199@1|root,COG3706@2|Bacteria,1G3FB@1117|Cyanobacteria,1HM2U@1161|Nostocales	1117|Cyanobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM,PAS_4,PAS_8
GDHHQS1_k127_11611990_0	573413.Spirs_1386	1.124e-166	539.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,2J6YZ@203691|Spirochaetes	203691|Spirochaetes	C	Selenate reductase YgfK	gltD	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
GDHHQS1_k127_11656594_0	96561.Dole_2961	1.532e-173	571.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2MIP5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH-like protein	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
GDHHQS1_k127_11656594_1	1040989.AWZU01000052_gene2531	8.783e-10	70.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2TSHF@28211|Alphaproteobacteria,3K08G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
GDHHQS1_k127_11822377_20	744872.Spica_1604	2.156e-29	117.0	COG1158@1|root,COG1158@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
GDHHQS1_k127_11822377_19	221027.JO40_11775	1.042e-31	125.0	COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes	203691|Spirochaetes	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
GDHHQS1_k127_11822377_17	1078020.KEK_14563	9.403e-43	166.0	COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,23528@1762|Mycobacteriaceae	201174|Actinobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
GDHHQS1_k127_11822377_24	243276.TPANIC_0262	6.651e-12	75.0	COG0664@1|root,COG0664@2|Bacteria,2J6ZR@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
GDHHQS1_k127_11822377_6	573413.Spirs_3175	1.535e-109	368.0	COG0153@1|root,COG0153@2|Bacteria,2J58W@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
GDHHQS1_k127_11822377_13	1123274.KB899429_gene2901	7.243e-72	250.0	COG0496@1|root,COG0496@2|Bacteria,2J7HR@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
GDHHQS1_k127_11822377_16	1123274.KB899429_gene2900	1.715e-54	201.0	COG0457@1|root,COG0457@2|Bacteria,2J6BA@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
GDHHQS1_k127_11822377_7	243276.TPANIC_0421	8.678e-109	377.0	COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
GDHHQS1_k127_11822377_14	935948.KE386495_gene1221	3.651e-70	244.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
GDHHQS1_k127_11822377_21	1123274.KB899408_gene3944	1.37e-20	93.0	COG1146@1|root,COG1146@2|Bacteria,2J9EV@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
GDHHQS1_k127_11822377_2	573413.Spirs_0610	1.482e-147	478.0	COG0674@1|root,COG0674@2|Bacteria,2J65R@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase, alpha subunit	porA6	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
GDHHQS1_k127_11822377_4	1123274.KB899408_gene3946	1.538e-117	382.0	COG1013@1|root,COG1013@2|Bacteria,2J6R4@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00175,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
GDHHQS1_k127_11822377_15	1123274.KB899408_gene3947	3.406e-56	212.0	COG1014@1|root,COG1014@2|Bacteria,2J8M0@203691|Spirochaetes	203691|Spirochaetes	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
GDHHQS1_k127_11822377_25	357808.RoseRS_4198	7.246e-06	56.0	2E64T@1|root,330TJ@2|Bacteria,2G93I@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11822377_22	760011.Spico_1230	1.656e-17	94.0	COG2983@1|root,COG2983@2|Bacteria,2JB4G@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0260 family	-	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	-
GDHHQS1_k127_11822377_3	237368.SCABRO_00441	3.549e-147	482.0	COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes	203682|Planctomycetes	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
GDHHQS1_k127_11822377_0	545695.TREAZ_0886	5.07e-179	589.0	COG0572@1|root,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
GDHHQS1_k127_11822377_12	1480694.DC28_03140	3e-76	270.0	COG2206@1|root,COG2206@2|Bacteria,2J6CD@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
GDHHQS1_k127_11822377_23	243276.TPANIC_0763	1.008e-13	81.0	2F691@1|root,33YSU@2|Bacteria,2J6FP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11822377_10	1307761.L21SP2_2857	4.088e-80	294.0	COG0609@1|root,COG0609@2|Bacteria,2J6D8@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
GDHHQS1_k127_11822377_9	889378.Spiaf_2248	1.297e-97	348.0	COG1120@1|root,COG1120@2|Bacteria,2J7N3@203691|Spirochaetes	203691|Spirochaetes	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
GDHHQS1_k127_11822377_5	1123274.KB899423_gene1590	6.168e-117	387.0	COG1816@1|root,COG1816@2|Bacteria,2J5HJ@203691|Spirochaetes	203691|Spirochaetes	F	Adenosine AMP deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
GDHHQS1_k127_11822377_18	573413.Spirs_2240	5.205e-36	147.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,2J72G@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	lysM	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Amidase_3,LysM,Peptidase_M23
GDHHQS1_k127_11822377_8	545694.TREPR_2469	2.14e-105	352.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS1_k127_11822377_1	744872.Spica_0771	1.077e-147	482.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS1_k127_11822377_11	1123274.KB899428_gene1851	9.809e-78	283.0	COG0664@1|root,COG1729@1|root,COG0664@2|Bacteria,COG1729@2|Bacteria,2J5MQ@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8,cNMP_binding
GDHHQS1_k127_11858334_2	525897.Dbac_2014	1.245e-55	199.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,2M8HV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS1_k127_11858334_3	1120985.AUMI01000018_gene2985	5.187e-22	107.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4H20F@909932|Negativicutes	909932|Negativicutes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
GDHHQS1_k127_11858334_1	1499967.BAYZ01000103_gene3735	5.677e-93	315.0	COG0709@1|root,COG0709@2|Bacteria,2NNUD@2323|unclassified Bacteria	2|Bacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C,Pyr_redox_2
GDHHQS1_k127_11858334_5	1238182.C882_1368	1.274e-08	66.0	COG3568@1|root,COG3568@2|Bacteria,1N7P6@1224|Proteobacteria,2UIJQ@28211|Alphaproteobacteria,2JXDC@204441|Rhodospirillales	204441|Rhodospirillales	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
GDHHQS1_k127_11858334_6	743719.PaelaDRAFT_5458	3.85e-08	66.0	COG0395@1|root,COG0395@2|Bacteria,1V20I@1239|Firmicutes,4IQNR@91061|Bacilli,276GA@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_11858334_0	861299.J421_4258	1.822e-148	486.0	COG0513@1|root,COG0513@2|Bacteria,1ZT7G@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	DEAD-like helicases superfamily	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
GDHHQS1_k127_11858334_4	1121904.ARBP01000001_gene5416	3.045e-11	69.0	2CC7E@1|root,2Z7WG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11900734_15	545695.TREAZ_0356	5.231e-17	93.0	COG0582@1|root,COG0582@2|Bacteria,2J6Z9@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
GDHHQS1_k127_11900734_8	1125700.HMPREF9195_01385	1.505e-53	206.0	COG1820@1|root,COG1820@2|Bacteria,2J5F5@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
GDHHQS1_k127_11900734_6	926569.ANT_20970	5.448e-74	268.0	COG1121@1|root,COG1121@2|Bacteria,2G7X2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	ko:K09820,ko:K11710	ko02010,map02010	M00243,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
GDHHQS1_k127_11900734_2	555079.Toce_2001	1.251e-169	561.0	COG2403@1|root,COG2403@2|Bacteria,1TPZD@1239|Firmicutes,24E2D@186801|Clostridia,42HSE@68295|Thermoanaerobacterales	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
GDHHQS1_k127_11900734_3	273068.TTE0532	1.305e-136	449.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,42EK4@68295|Thermoanaerobacterales	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
GDHHQS1_k127_11900734_14	744872.Spica_1101	7.927e-18	89.0	29BJG@1|root,2ZYHU@2|Bacteria,2J7F5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11900734_4	545695.TREAZ_3136	4.039e-83	289.0	COG0006@1|root,COG0006@2|Bacteria,2J6QH@203691|Spirochaetes	203691|Spirochaetes	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
GDHHQS1_k127_11900734_5	545694.TREPR_3811	1.565e-75	272.0	COG0618@1|root,COG0618@2|Bacteria,2J6GG@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
GDHHQS1_k127_11900734_13	665571.STHERM_c05770	1.876e-18	95.0	2AMT3@1|root,31CPK@2|Bacteria,2J8CQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11900734_7	573413.Spirs_1289	1.439e-56	203.0	COG0127@1|root,COG0127@2|Bacteria,2J7BY@203691|Spirochaetes	203691|Spirochaetes	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
GDHHQS1_k127_11900734_10	665571.STHERM_c16860	1.052e-44	183.0	COG1597@1|root,COG1597@2|Bacteria,2J5GC@203691|Spirochaetes	203691|Spirochaetes	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
GDHHQS1_k127_11900734_9	1125863.JAFN01000001_gene1728	2.667e-46	182.0	COG0477@1|root,COG2814@2|Bacteria,1P2GY@1224|Proteobacteria,42MWI@68525|delta/epsilon subdivisions,2WK29@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_11900734_12	744872.Spica_1054	1.055e-19	92.0	2DHD2@1|root,2ZZ9P@2|Bacteria,2J959@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_11900734_0	1128421.JAGA01000003_gene2953	2.522e-294	962.0	COG0366@1|root,COG0366@2|Bacteria,2NQQN@2323|unclassified Bacteria	2|Bacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
GDHHQS1_k127_11900734_1	889378.Spiaf_0101	8.132e-177	575.0	COG1640@1|root,COG1640@2|Bacteria,2J62I@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
GDHHQS1_k127_11900734_11	768671.ThimaDRAFT_0519	5.931e-44	160.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,1RP0B@1236|Gammaproteobacteria,1WX6H@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
GDHHQS1_k127_12025572_0	452637.Oter_0092	4.728e-150	493.0	COG0745@1|root,COG0784@1|root,COG2202@1|root,COG3452@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3452@2|Bacteria,COG5002@2|Bacteria,46TZ6@74201|Verrucomicrobia,3K8NE@414999|Opitutae	414999|Opitutae	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
GDHHQS1_k127_12084181_3	158189.SpiBuddy_2664	1.616e-19	94.0	COG1802@1|root,COG1802@2|Bacteria,2J9GT@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
GDHHQS1_k127_12084181_5	700598.Niako_1360	1.163e-16	95.0	COG0383@1|root,COG0383@2|Bacteria,4NIM9@976|Bacteroidetes,1IR3M@117747|Sphingobacteriia	976|Bacteroidetes	G	glycoside hydrolase family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
GDHHQS1_k127_12084181_1	765698.Mesci_6266	4.673e-42	167.0	COG0395@1|root,COG0395@2|Bacteria,1QHIK@1224|Proteobacteria,2U2IY@28211|Alphaproteobacteria,43I49@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K02026,ko:K10119	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
GDHHQS1_k127_12084181_2	1306990.BARG01000088_gene8760	5.467e-42	165.0	COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_12084181_4	1235799.C818_03452	3.112e-17	96.0	COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,27KJE@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_12084181_0	309803.CTN_0403	7.01e-68	257.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C,Glyco_hydro_79n
GDHHQS1_k127_1227701_20	1480694.DC28_05555	5.425e-18	85.0	COG1758@1|root,COG1758@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
GDHHQS1_k127_1227701_6	573413.Spirs_2278	1.043e-78	274.0	COG0324@1|root,COG0324@2|Bacteria,2J6T2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
GDHHQS1_k127_1227701_22	1236959.BAMT01000001_gene1053	1.383e-06	59.0	COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2VQDX@28216|Betaproteobacteria,2KMM4@206350|Nitrosomonadales	206350|Nitrosomonadales	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
GDHHQS1_k127_1227701_1	665571.STHERM_c18390	7.165e-210	671.0	COG1154@1|root,COG1154@2|Bacteria,2J5NP@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
GDHHQS1_k127_1227701_8	1121861.KB899910_gene633	1.482e-74	261.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria,2JP97@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
GDHHQS1_k127_1227701_7	1123274.KB899413_gene771	2.449e-76	272.0	COG1624@1|root,COG1624@2|Bacteria,2J5ZB@203691|Spirochaetes	203691|Spirochaetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
GDHHQS1_k127_1227701_13	1123274.KB899413_gene770	1.453e-58	216.0	COG4856@1|root,COG4856@2|Bacteria,2J5XW@203691|Spirochaetes	203691|Spirochaetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
GDHHQS1_k127_1227701_17	665571.STHERM_c18350	2.672e-33	132.0	COG0736@1|root,COG0736@2|Bacteria,2J8AA@203691|Spirochaetes	203691|Spirochaetes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
GDHHQS1_k127_1227701_5	665571.STHERM_c18340	7.092e-95	325.0	COG1655@1|root,COG1655@2|Bacteria,2J5GN@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225
GDHHQS1_k127_1227701_10	665571.STHERM_c18330	1.351e-69	248.0	COG0101@1|root,COG0101@2|Bacteria,2J65Z@203691|Spirochaetes	203691|Spirochaetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
GDHHQS1_k127_1227701_11	1123274.KB899413_gene766	2.268e-62	222.0	COG1573@1|root,COG1573@2|Bacteria,2J612@203691|Spirochaetes	203691|Spirochaetes	L	Uracil-DNA glycosylase, family 4	ung	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
GDHHQS1_k127_1227701_0	889378.Spiaf_1079	4.251e-216	689.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
GDHHQS1_k127_1227701_14	744872.Spica_2334	2.102e-45	173.0	COG0242@1|root,COG0242@2|Bacteria,2J7X0@203691|Spirochaetes	203691|Spirochaetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
GDHHQS1_k127_1227701_9	665571.STHERM_c20370	6.893e-73	263.0	COG0223@1|root,COG0223@2|Bacteria,2J621@203691|Spirochaetes	203691|Spirochaetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
GDHHQS1_k127_1227701_12	545694.TREPR_1180	4.996e-60	228.0	COG2815@1|root,COG2815@2|Bacteria,2J5J2@203691|Spirochaetes	203691|Spirochaetes	S	Pasta domain protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
GDHHQS1_k127_1227701_19	317619.ANKN01000024_gene1590	1.167e-23	115.0	COG3464@1|root,COG3464@2|Bacteria,1G9CU@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1227701_3	1499967.BAYZ01000028_gene1264	1.478e-120	398.0	COG1181@1|root,COG1181@2|Bacteria,2NRF0@2323|unclassified Bacteria	2|Bacteria	M	ATP-grasp domain	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
GDHHQS1_k127_1227701_2	1121428.DESHY_30083___1	1.868e-192	618.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
GDHHQS1_k127_1227701_16	696369.KI912183_gene2143	1.525e-43	167.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,261U9@186807|Peptococcaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
GDHHQS1_k127_1227701_4	1123508.JH636448_gene7605	2.356e-104	352.0	COG0624@1|root,COG0624@2|Bacteria,2IYA5@203682|Planctomycetes	203682|Planctomycetes	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
GDHHQS1_k127_1227701_18	419665.Maeo_0434	7.148e-24	115.0	COG0668@1|root,arCOG01569@2157|Archaea,2XVK0@28890|Euryarchaeota,23QTX@183939|Methanococci	183939|Methanococci	M	PFAM MscS Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
GDHHQS1_k127_1227701_21	1048834.TC41_3302	4.356e-08	65.0	COG1475@1|root,COG1475@2|Bacteria,1TP0I@1239|Firmicutes,4HAC6@91061|Bacilli,278Q7@186823|Alicyclobacillaceae	91061|Bacilli	K	Belongs to the ParB family	noc	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
GDHHQS1_k127_1227701_15	404380.Gbem_3571	5.434e-44	185.0	COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria	1224|Proteobacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
GDHHQS1_k127_12424383_1	646529.Desaci_3401	1.526e-173	582.0	COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,248SW@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1
GDHHQS1_k127_12424383_4	329726.AM1_2305	5.418e-06	57.0	COG0745@1|root,COG5001@1|root,COG0745@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
GDHHQS1_k127_12424383_0	1499967.BAYZ01000061_gene5928	7.791e-311	961.0	COG2759@1|root,COG2759@2|Bacteria,2NP2R@2323|unclassified Bacteria	2|Bacteria	F	Formate--tetrahydrofolate ligase	fhs	GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.5,3.5.4.9,6.3.4.3	ko:K00288,ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00141,M00377	R00943,R01220,R01655	RC00026,RC00111,RC00202,RC00578	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FTHFS
GDHHQS1_k127_12424383_2	1128421.JAGA01000003_gene3015	2.82e-143	473.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2NP92@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrE	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585,iYO844.BSU15560	OMPdecase,Pribosyltran
GDHHQS1_k127_12424383_3	926550.CLDAP_25040	1.003e-43	167.0	COG0167@1|root,COG0167@2|Bacteria,2G6RH@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
GDHHQS1_k127_12435419_12	357808.RoseRS_3074	1.212e-47	179.0	COG0667@1|root,COG0667@2|Bacteria,2G6BF@200795|Chloroflexi,377XY@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_12435419_10	457398.HMPREF0326_01309	1.716e-53	201.0	COG0679@1|root,COG0679@2|Bacteria,1QKS6@1224|Proteobacteria,435R5@68525|delta/epsilon subdivisions,2X05P@28221|Deltaproteobacteria,2MAPN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	-
GDHHQS1_k127_12435419_0	1293054.HSACCH_01641	4.746e-208	658.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,24ZIP@186801|Clostridia	186801|Clostridia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
GDHHQS1_k127_12435419_14	1293054.HSACCH_01640	2.312e-28	125.0	2ECQ5@1|root,336MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12435419_2	1211115.ALIQ01000198_gene465	1.94e-111	381.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VFM7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
GDHHQS1_k127_12435419_15	1121904.ARBP01000008_gene3235	2.665e-28	130.0	COG1802@1|root,COG1802@2|Bacteria,4NM2G@976|Bacteroidetes,47MD6@768503|Cytophagia	976|Bacteroidetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
GDHHQS1_k127_12435419_16	1121904.ARBP01000008_gene3235	2.857e-28	130.0	COG1802@1|root,COG1802@2|Bacteria,4NM2G@976|Bacteroidetes,47MD6@768503|Cytophagia	976|Bacteroidetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
GDHHQS1_k127_12435419_9	1111728.ATYS01000011_gene373	1.506e-58	217.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,1RRUP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	quinone reductase	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
GDHHQS1_k127_12435419_11	1121346.KB899876_gene1732	2.169e-50	185.0	COG3822@1|root,COG3822@2|Bacteria,1V1ZU@1239|Firmicutes,4HHR0@91061|Bacilli,26W0Q@186822|Paenibacillaceae	91061|Bacilli	S	D-lyxose isomerase	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
GDHHQS1_k127_12435419_18	309800.C498_02590	6.237e-07	60.0	COG1082@1|root,arCOG01900@2157|Archaea,2Y7HU@28890|Euryarchaeota,241HN@183963|Halobacteria	183963|Halobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_12435419_8	1385514.N782_15215	6.239e-60	228.0	COG1082@1|root,COG1082@2|Bacteria,1UITG@1239|Firmicutes,4HFIC@91061|Bacilli	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_12435419_3	1121430.JMLG01000004_gene963	2.054e-98	330.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
GDHHQS1_k127_12435419_6	457570.Nther_2213	4.746e-66	238.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_12435419_5	1150399.AQYK01000002_gene2685	9.561e-71	263.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4FMVB@85023|Microbacteriaceae	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
GDHHQS1_k127_12435419_4	1232449.BAHV02000008_gene670	5.25e-91	310.0	COG0176@1|root,COG0176@2|Bacteria,1U9RA@1239|Firmicutes,24DCI@186801|Clostridia	186801|Clostridia	H	PFAM Transaldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
GDHHQS1_k127_12435419_17	1122917.KB899663_gene2758	2.407e-13	84.0	2DMXT@1|root,32UAK@2|Bacteria,1U8NH@1239|Firmicutes,4ICTZ@91061|Bacilli,272ST@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12435419_1	743719.PaelaDRAFT_0996	1.272e-176	564.0	COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,4IRIM@91061|Bacilli,26T43@186822|Paenibacillaceae	91061|Bacilli	O	Crystallin	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
GDHHQS1_k127_12435419_7	1122927.KB895413_gene1949	3.455e-65	244.0	COG2972@1|root,COG2972@2|Bacteria,1TSQR@1239|Firmicutes,4I7AG@91061|Bacilli,26WAA@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase
GDHHQS1_k127_12435419_13	742735.HMPREF9467_04479	3.681e-39	160.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYGS@1239|Firmicutes,24ADJ@186801|Clostridia,21YHA@1506553|Lachnoclostridium	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HTH_18,HTH_AraC,Response_reg
GDHHQS1_k127_1248036_8	497964.CfE428DRAFT_1593	1.108e-07	54.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,LRR_5
GDHHQS1_k127_1248036_0	521098.Aaci_0152	2.15e-157	511.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli	91061|Bacilli	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS1_k127_1248036_5	644966.Tmar_1516	3.855e-22	106.0	COG3255@1|root,COG3255@2|Bacteria,1V7IH@1239|Firmicutes	1239|Firmicutes	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
GDHHQS1_k127_1248036_3	357808.RoseRS_2082	1.729e-88	310.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi,37537@32061|Chloroflexia	32061|Chloroflexia	C	PFAM iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
GDHHQS1_k127_1248036_2	768704.Desmer_2448	9.484e-109	361.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,24BVW@186801|Clostridia,263MB@186807|Peptococcaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
GDHHQS1_k127_1248036_4	1123290.AUDQ01000011_gene1565	4.502e-42	164.0	COG2258@1|root,COG2258@2|Bacteria,1UB2C@1239|Firmicutes,4HB26@91061|Bacilli,26EWH@186818|Planococcaceae	91061|Bacilli	S	MOSC domain	yflK	-	-	-	-	-	-	-	-	-	-	-	3-alpha,MOSC
GDHHQS1_k127_1248036_1	926569.ANT_06990	3.072e-154	499.0	COG2317@1|root,COG2317@2|Bacteria,2G7UQ@200795|Chloroflexi	200795|Chloroflexi	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
GDHHQS1_k127_12518290_0	744872.Spica_1421	1.909e-105	359.0	COG0750@1|root,COG0750@2|Bacteria,2J616@203691|Spirochaetes	203691|Spirochaetes	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
GDHHQS1_k127_12518290_1	665571.STHERM_c13110	7.618e-92	329.0	COG0743@1|root,COG0743@2|Bacteria,2J5M4@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
GDHHQS1_k127_12518290_3	744872.Spica_1419	5.915e-33	143.0	COG4589@1|root,COG4589@2|Bacteria,2J7JM@203691|Spirochaetes	203691|Spirochaetes	S	Phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
GDHHQS1_k127_12518290_2	545695.TREAZ_0620	1.518e-42	159.0	COG0020@1|root,COG0020@2|Bacteria,2J5Y6@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
GDHHQS1_k127_12550190_4	744872.Spica_0331	2.09e-121	397.0	COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes	203691|Spirochaetes	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	malP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
GDHHQS1_k127_12550190_8	665571.STHERM_c01930	1.776e-66	234.0	COG1811@1|root,COG1811@2|Bacteria,2J7KZ@203691|Spirochaetes	203691|Spirochaetes	S	Na channel or pump	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
GDHHQS1_k127_12550190_0	1449063.JMLS01000001_gene4614	8.269e-208	657.0	COG0673@1|root,COG0673@2|Bacteria,1TSUT@1239|Firmicutes,4HDBM@91061|Bacilli,26R1T@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	yteT	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_12550190_11	1307761.L21SP2_0278	1.898e-15	84.0	28VUA@1|root,2ZHVZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12550190_5	744872.Spica_2328	3.038e-103	353.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
GDHHQS1_k127_12550190_3	272562.CA_C0014	1.226e-134	438.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
GDHHQS1_k127_12550190_12	1125725.HMPREF1325_2615	8.977e-05	49.0	2A5S9@1|root,30UHC@2|Bacteria,2J8RT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12550190_2	665571.STHERM_c13320	1.952e-147	480.0	COG0462@1|root,COG0462@2|Bacteria,2J5IY@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
GDHHQS1_k127_12550190_6	459349.CLOAM1469	6.942e-91	308.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	galE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
GDHHQS1_k127_12550190_1	1123274.KB899426_gene2795	1.006e-199	650.0	COG0726@1|root,COG0726@2|Bacteria,2J5Y1@203691|Spirochaetes	203691|Spirochaetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Polysacc_deac_1
GDHHQS1_k127_12550190_9	573413.Spirs_3678	1.255e-32	131.0	COG1516@1|root,COG1516@2|Bacteria,2J7XT@203691|Spirochaetes	203691|Spirochaetes	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
GDHHQS1_k127_12550190_10	744872.Spica_0451	1.952e-25	117.0	2FBJ1@1|root,343Q9@2|Bacteria,2J8G6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
GDHHQS1_k127_12550190_7	573413.Spirs_3676	2.606e-88	310.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
GDHHQS1_k127_1258993_4	1286171.EAL2_c07880	2.243e-11	66.0	COG3945@1|root,COG3945@2|Bacteria,1V3TS@1239|Firmicutes,24HUR@186801|Clostridia	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
GDHHQS1_k127_1258993_0	329726.AM1_4939	6.097e-94	333.0	COG0591@1|root,COG0591@2|Bacteria,1G3QJ@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
GDHHQS1_k127_1258993_2	580331.Thit_0082	8.477e-73	257.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,42FGP@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
GDHHQS1_k127_1258993_3	500153.JOEK01000008_gene2347	2.574e-33	143.0	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria	201174|Actinobacteria	M	Epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
GDHHQS1_k127_1258993_1	1304880.JAGB01000002_gene2183	2.133e-81	281.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
GDHHQS1_k127_12602361_6	180332.JTGN01000024_gene1707	4.898e-104	347.0	COG0407@1|root,COG0407@2|Bacteria	180332.JTGN01000024_gene1707|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12602361_1	1123274.KB899410_gene3555	2.308e-218	704.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS1_k127_12602361_3	573413.Spirs_3743	8.794e-153	500.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS1_k127_12602361_4	1123274.KB899410_gene3557	6.862e-147	471.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
GDHHQS1_k127_12602361_2	573413.Spirs_3741	2.619e-162	521.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_12602361_5	351160.LRC381	1.599e-126	412.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,2N9H8@224756|Methanomicrobia	224756|Methanomicrobia	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
GDHHQS1_k127_12602361_8	448385.sce0767	1.184e-86	299.0	COG1305@1|root,COG1305@2|Bacteria,1R9WH@1224|Proteobacteria	1224|Proteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
GDHHQS1_k127_12602361_13	591157.SSLG_02172	8.737e-41	159.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
GDHHQS1_k127_12602361_7	1121430.JMLG01000005_gene792	3.091e-87	305.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
GDHHQS1_k127_12602361_10	665571.STHERM_c05610	9.859e-55	205.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
GDHHQS1_k127_12602361_0	1123274.KB899407_gene229	1.646e-250	788.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
GDHHQS1_k127_12602361_14	1278073.MYSTI_05190	1.516e-24	113.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YVKS@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS1_k127_12602361_11	744872.Spica_2104	3.822e-49	200.0	2EW9N@1|root,33PNA@2|Bacteria,2J5CY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12602361_12	665571.STHERM_c03850	3.346e-44	166.0	2CA4A@1|root,32RQK@2|Bacteria,2J92B@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4416)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4416
GDHHQS1_k127_12602361_16	545695.TREAZ_3211	1.352e-05	56.0	2AMTU@1|root,31CQC@2|Bacteria,2J8FI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12602361_9	794903.OPIT5_07690	2.668e-63	239.0	COG3170@1|root,COG3170@2|Bacteria,46Y8C@74201|Verrucomicrobia,3K93X@414999|Opitutae	414999|Opitutae	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12610773_0	1121406.JAEX01000006_gene2200	9.78e-76	270.0	COG0642@1|root,COG2205@2|Bacteria,1R7QH@1224|Proteobacteria,42PSC@68525|delta/epsilon subdivisions,2WKFW@28221|Deltaproteobacteria,2M8HM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_5,PAS_8
GDHHQS1_k127_12610773_1	357808.RoseRS_0293	3.969e-46	191.0	COG0308@1|root,COG0308@2|Bacteria,2G75V@200795|Chloroflexi,375Q4@32061|Chloroflexia	32061|Chloroflexia	M	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
GDHHQS1_k127_12610773_2	66377.JOBH01000004_gene3736	1.478e-41	167.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
GDHHQS1_k127_12610773_3	29306.JOBE01000022_gene532	1.515e-20	95.0	COG1063@1|root,COG1063@2|Bacteria,2GNXK@201174|Actinobacteria	201174|Actinobacteria	E	Dehydrogenase	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_12642565_3	880073.Calab_0900	2.032e-51	192.0	COG2078@1|root,COG2078@2|Bacteria,2NPQ0@2323|unclassified Bacteria	2|Bacteria	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
GDHHQS1_k127_12642565_5	744872.Spica_0999	3.916e-31	135.0	COG1355@1|root,COG1355@2|Bacteria,2J963@203691|Spirochaetes	203691|Spirochaetes	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
GDHHQS1_k127_12642565_1	926550.CLDAP_14190	2.211e-78	265.0	COG1945@1|root,COG1945@2|Bacteria	2|Bacteria	I	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
GDHHQS1_k127_12642565_0	1128421.JAGA01000004_gene2510	4.51e-154	501.0	COG1899@1|root,COG1899@2|Bacteria,2NR8I@2323|unclassified Bacteria	2|Bacteria	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
GDHHQS1_k127_12642565_2	926550.CLDAP_14200	5.207e-78	271.0	COG0010@1|root,COG0010@2|Bacteria,2G6IN@200795|Chloroflexi	200795|Chloroflexi	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
GDHHQS1_k127_12642565_4	1429851.X548_00575	6.303e-42	158.0	COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,1S6FE@1236|Gammaproteobacteria,1X739@135614|Xanthomonadales	135614|Xanthomonadales	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	-
GDHHQS1_k127_12660117_5	319225.Plut_2084	9.112e-22	96.0	COG0167@1|root,COG0167@2|Bacteria,1FDV5@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
GDHHQS1_k127_12660117_0	670487.Ocepr_0973	2.592e-76	265.0	COG0476@1|root,COG0476@2|Bacteria,1WIMK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	COGs COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
GDHHQS1_k127_12660117_6	278957.ABEA03000083_gene2692	2.077e-12	79.0	COG1082@1|root,COG1082@2|Bacteria,46XBZ@74201|Verrucomicrobia,3K8IZ@414999|Opitutae	414999|Opitutae	G	Xylose isomerase-like TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_12660117_4	663278.Ethha_0219	1.883e-47	175.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,3WIYS@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
GDHHQS1_k127_12660117_3	395961.Cyan7425_1474	1.646e-49	181.0	COG0757@1|root,COG0757@2|Bacteria,1G5X4@1117|Cyanobacteria,3KI19@43988|Cyanothece	1117|Cyanobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
GDHHQS1_k127_12660117_7	1232410.KI421420_gene3128	0.0006094	51.0	COG1977@1|root,COG1977@2|Bacteria,1P1VY@1224|Proteobacteria,431KF@68525|delta/epsilon subdivisions,2WX00@28221|Deltaproteobacteria,43VH2@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	ThiS family	moaD-1	-	-	-	-	-	-	-	-	-	-	-	ThiS
GDHHQS1_k127_12660117_2	1382356.JQMP01000001_gene1176	7.228e-66	239.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS1_k127_12660117_1	1038862.KB893840_gene1188	2.81e-72	252.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria,3JSAU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_12729409_1	215803.DB30_4895	2.275e-115	376.0	COG0667@1|root,COG0667@2|Bacteria,1Q2VX@1224|Proteobacteria,438IJ@68525|delta/epsilon subdivisions,2X3TE@28221|Deltaproteobacteria,2YX2D@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_12729409_4	1121920.AUAU01000014_gene2790	6.278e-13	79.0	2EK70@1|root,33DXD@2|Bacteria,3Y5QD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12729409_3	1250232.JQNJ01000001_gene2685	4.035e-13	77.0	COG0454@1|root,COG0456@2|Bacteria,4NUI2@976|Bacteroidetes,1I4HH@117743|Flavobacteriia	976|Bacteroidetes	K	GCN5 family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS1_k127_12729409_2	1408473.JHXO01000008_gene2812	8.1e-46	180.0	COG3049@1|root,COG3049@2|Bacteria,4NGDB@976|Bacteroidetes	976|Bacteroidetes	M	Choloylglycine hydrolase	cbh	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
GDHHQS1_k127_12729409_0	1125863.JAFN01000001_gene2425	6.196e-138	449.0	COG4656@1|root,COG4656@2|Bacteria,1PJE1@1224|Proteobacteria,42P69@68525|delta/epsilon subdivisions,2WIM9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB
GDHHQS1_k127_12756469_1	696369.KI912183_gene2158	1.149e-166	549.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,248AI@186801|Clostridia,260EE@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
GDHHQS1_k127_12756469_8	1392502.JNIO01000002_gene472	6.712e-08	62.0	COG4729@1|root,COG4729@2|Bacteria,1VBFA@1239|Firmicutes,4H5G2@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF1850)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1850
GDHHQS1_k127_12756469_2	1121468.AUBR01000007_gene235	1.527e-94	319.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia,42FRJ@68295|Thermoanaerobacterales	186801|Clostridia	S	NMT1-like family	bcsP	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
GDHHQS1_k127_12756469_7	1307761.L21SP2_3448	5.319e-26	118.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
GDHHQS1_k127_12756469_3	756499.Desde_2069	6.933e-49	190.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
GDHHQS1_k127_12756469_6	616991.JPOO01000001_gene4601	5.035e-30	130.0	COG5580@1|root,COG5580@2|Bacteria,4PK53@976|Bacteroidetes,1I3SX@117743|Flavobacteriia	976|Bacteroidetes	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS1_k127_12756469_5	1125863.JAFN01000001_gene1803	1.359e-37	153.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Tellurite resistance protein TerB	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
GDHHQS1_k127_12756469_0	573413.Spirs_0147	5.727e-180	575.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
GDHHQS1_k127_12756469_4	1480694.DC28_07915	3.736e-48	181.0	COG1752@1|root,COG1752@2|Bacteria,2J6JW@203691|Spirochaetes	203691|Spirochaetes	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
GDHHQS1_k127_12756978_1	744872.Spica_2768	7.289e-41	157.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365,ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
GDHHQS1_k127_12756978_2	648996.Theam_1388	7.535e-27	122.0	COG1434@1|root,COG1434@2|Bacteria,2G45V@200783|Aquificae	200783|Aquificae	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
GDHHQS1_k127_12756978_3	907348.TresaDRAFT_0127	1.701e-15	86.0	2BRMP@1|root,32KM3@2|Bacteria,2J6W4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
GDHHQS1_k127_12756978_0	177437.HRM2_08770	4.125e-64	228.0	COG2199@1|root,COG3706@2|Bacteria,1N2X1@1224|Proteobacteria,42TUZ@68525|delta/epsilon subdivisions,2WQ1Q@28221|Deltaproteobacteria,2MKGE@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Carbohydrate-binding family 9	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_2
GDHHQS1_k127_12756978_4	1463854.JOHT01000009_gene1290	2.67e-14	85.0	COG0637@1|root,COG0637@2|Bacteria,2I362@201174|Actinobacteria	201174|Actinobacteria	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
GDHHQS1_k127_12757295_2	665571.STHERM_c11570	6.987e-91	304.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
GDHHQS1_k127_12757295_3	326424.FRAAL6653	7.632e-08	63.0	COG2340@1|root,COG2340@2|Bacteria,2GM57@201174|Actinobacteria,4EWAF@85013|Frankiales	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
GDHHQS1_k127_12757295_1	744872.Spica_0781	5.94e-217	688.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
GDHHQS1_k127_12757295_0	665571.STHERM_c15920	0.0	1462.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
GDHHQS1_k127_12809780_0	660470.Theba_0060	1.54e-107	358.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
GDHHQS1_k127_12809780_1	1007103.AFHW01000058_gene4111	8.61e-20	106.0	COG2931@1|root,COG5184@1|root,COG2931@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.4.24.40	ko:K01406,ko:K20276,ko:K21449	ko01503,ko02024,map01503,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.40.2	-	-	Cadherin-like,Calx-beta,DUF4347,He_PIG,HemolysinCabind,Ice_nucleation,SLH
GDHHQS1_k127_12809780_2	426114.THI_2852	8.17e-08	54.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria	28216|Betaproteobacteria	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
GDHHQS1_k127_12815577_2	644282.Deba_0061	4.11e-29	122.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
GDHHQS1_k127_12815577_1	644282.Deba_1916	3.944e-117	400.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_12815577_0	1304880.JAGB01000002_gene1641	1.978e-164	527.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
GDHHQS1_k127_12825298_4	1499967.BAYZ01000075_gene2070	1.761e-106	358.0	COG0508@1|root,COG0508@2|Bacteria,2NNYD@2323|unclassified Bacteria	2|Bacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	pdhC	-	1.2.4.1,2.3.1.12	ko:K00162,ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R02569,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
GDHHQS1_k127_12825298_0	889378.Spiaf_1800	2.239e-171	569.0	COG1249@1|root,COG1249@2|Bacteria,2J7JJ@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
GDHHQS1_k127_12825298_9	665571.STHERM_c20410	6.233e-63	231.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
GDHHQS1_k127_12825298_3	742738.HMPREF9460_00237	1.121e-142	460.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,2681M@186813|unclassified Clostridiales	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
GDHHQS1_k127_12825298_5	1304875.JAFZ01000001_gene1076	3.013e-104	366.0	COG0800@1|root,COG0800@2|Bacteria,3TAVM@508458|Synergistetes	508458|Synergistetes	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
GDHHQS1_k127_12825298_6	665571.STHERM_c04240	9.562e-100	350.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.399,1.1.1.95	ko:K00058,ko:K04496	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko04310,ko04330,ko05200,ko05220,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map04310,map04330,map05200,map05220	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GDHHQS1_k127_12825298_7	1304880.JAGB01000001_gene865	1.688e-96	334.0	COG0673@1|root,COG0673@2|Bacteria,1UIIC@1239|Firmicutes,249KE@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_12825298_1	1499967.BAYZ01000143_gene6126	4.479e-151	490.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
GDHHQS1_k127_12825298_12	744872.Spica_2713	4.99e-06	57.0	2ANU6@1|root,31DUH@2|Bacteria,2JB1T@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12825298_11	557599.MKAN_21915	7.95e-14	77.0	COG1487@1|root,COG1487@2|Bacteria,2INNM@201174|Actinobacteria,23BPH@1762|Mycobacteriaceae	201174|Actinobacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_12825298_10	96561.Dole_3166	7.525e-17	85.0	COG2002@1|root,COG2002@2|Bacteria,1NFWR@1224|Proteobacteria,42WSB@68525|delta/epsilon subdivisions,2WSD6@28221|Deltaproteobacteria,2MP5S@213118|Desulfobacterales	28221|Deltaproteobacteria	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
GDHHQS1_k127_12825298_2	744872.Spica_2535	1.429e-148	479.0	COG4608@1|root,COG4608@2|Bacteria,2J5YH@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_12825298_8	1321815.HMPREF9193_01215	1.009e-84	283.0	COG0444@1|root,COG0444@2|Bacteria,2J62R@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_12825458_2	1183377.Py04_0413	5.631e-18	99.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,242W8@183968|Thermococci	183968|Thermococci	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
GDHHQS1_k127_12825458_0	290512.Paes_1952	4.783e-37	159.0	COG0451@1|root,COG0451@2|Bacteria,1FDVP@1090|Chlorobi	1090|Chlorobi	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
GDHHQS1_k127_12825458_3	649638.Trad_1558	2.068e-11	73.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
GDHHQS1_k127_12825458_1	1236504.HMPREF2132_06390	1.371e-27	125.0	COG0451@1|root,COG0451@2|Bacteria,4NEJJ@976|Bacteroidetes,2FNM5@200643|Bacteroidia	976|Bacteroidetes	M	NAD dependent epimerase dehydratase family protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
GDHHQS1_k127_12946583_3	1499967.BAYZ01000104_gene3710	2.024e-41	164.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	rnaZ	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
GDHHQS1_k127_12946583_4	1123386.AUIW01000009_gene1812	8.972e-28	122.0	COG1848@1|root,COG1848@2|Bacteria,1WKJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12946583_5	933262.AXAM01000011_gene1792	6.325e-05	49.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
GDHHQS1_k127_12946583_0	1268240.ATFI01000001_gene2728	1.18e-62	235.0	COG5434@1|root,COG5434@2|Bacteria,4NICS@976|Bacteroidetes,2FMGC@200643|Bacteroidia,4APJS@815|Bacteroidaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
GDHHQS1_k127_12946583_2	1480694.DC28_09585	2.453e-46	188.0	2FEQT@1|root,346PZ@2|Bacteria,2J6IX@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12946583_1	665571.STHERM_c01370	1.774e-61	226.0	COG0457@1|root,COG0457@2|Bacteria,2J5N2@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
GDHHQS1_k127_12987490_1	1133850.SHJG_8808	2.473e-27	114.0	COG3212@1|root,COG3212@2|Bacteria,2IF4I@201174|Actinobacteria	201174|Actinobacteria	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_12987490_0	744872.Spica_1618	0.0	1042.0	COG1197@1|root,COG1197@2|Bacteria,2J63X@203691|Spirochaetes	203691|Spirochaetes	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
GDHHQS1_k127_13025866_6	439235.Dalk_5160	1.35e-13	73.0	2E9C8@1|root,333JY@2|Bacteria,1PAR4@1224|Proteobacteria,432FD@68525|delta/epsilon subdivisions,2WY2S@28221|Deltaproteobacteria,2MP8E@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13025866_8	1038859.AXAU01000011_gene2414	1.192e-09	67.0	COG3070@1|root,COG3070@2|Bacteria,1P6Z6@1224|Proteobacteria	1224|Proteobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
GDHHQS1_k127_13025866_4	192952.MM_2919	1.36e-18	90.0	COG0599@1|root,arCOG02151@2157|Archaea,2Y0W0@28890|Euryarchaeota,2NB47@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
GDHHQS1_k127_13025866_3	504472.Slin_5531	6.194e-21	94.0	COG2442@1|root,COG2442@2|Bacteria,4NX9P@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
GDHHQS1_k127_13025866_7	1041139.KB902680_gene1815	1.38e-12	74.0	COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria,4BDYP@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	MA20_05250	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS1_k127_13025866_5	1121929.KB898675_gene2180	5.978e-16	89.0	COG4392@1|root,COG4392@2|Bacteria,1VBUN@1239|Firmicutes,4HKJZ@91061|Bacilli,4712E@74385|Gracilibacillus	91061|Bacilli	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
GDHHQS1_k127_13025866_2	986075.CathTA2_1101	5.521e-46	176.0	COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,4HCET@91061|Bacilli	91061|Bacilli	E	branched-chain amino acid	ygaZ	-	-	-	-	-	-	-	-	-	-	-	AzlC
GDHHQS1_k127_13025866_0	338963.Pcar_2044	1.578e-116	381.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria,43S7P@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS1_k127_13025866_1	518766.Rmar_0136	6.874e-51	183.0	COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes,1FJ3Z@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Lysine-2,3-aminomutase	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
GDHHQS1_k127_13046260_2	402777.KB235904_gene3423	5.721e-05	56.0	COG0279@1|root,COG0279@2|Bacteria,1G1I9@1117|Cyanobacteria,1HDBA@1150|Oscillatoriales	1117|Cyanobacteria	G	SIS domain	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1,SIS_2
GDHHQS1_k127_13046260_0	1244869.H261_07973	9.759e-156	506.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1R7DJ@1224|Proteobacteria,2VF2S@28211|Alphaproteobacteria,2JT8E@204441|Rhodospirillales	204441|Rhodospirillales	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
GDHHQS1_k127_13050623_0	573413.Spirs_0312	6.111e-263	821.0	COG0173@1|root,COG0173@2|Bacteria,2J5KG@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
GDHHQS1_k127_13050623_5	1499967.BAYZ01000190_gene3853	1.113e-85	307.0	COG0407@1|root,COG0407@2|Bacteria,2NPXG@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_13050623_7	1124982.MSI_15590	6.509e-06	56.0	COG0716@1|root,COG0716@2|Bacteria,2J8GW@203691|Spirochaetes	203691|Spirochaetes	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
GDHHQS1_k127_13050623_2	1121904.ARBP01000005_gene4588	4.828e-171	564.0	COG0726@1|root,COG0726@2|Bacteria,4NNN4@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyl hydrolase family 9	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
GDHHQS1_k127_13050623_4	509191.AEDB02000093_gene3407	9.877e-95	333.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,24CHT@186801|Clostridia,3WHM6@541000|Ruminococcaceae	186801|Clostridia	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
GDHHQS1_k127_13050623_6	744872.Spica_1941	1.865e-17	85.0	COG0227@1|root,COG0227@2|Bacteria,2J8S4@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
GDHHQS1_k127_13050623_1	555079.Toce_0243	1.427e-202	667.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.10,1.17.1.9,1.97.1.9	ko:K00123,ko:K12527,ko:K15022	ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519,R07229	RC02420,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
GDHHQS1_k127_13050623_3	351627.Csac_0620	4.431e-137	441.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42I0X@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
GDHHQS1_k127_13058661_7	1235835.C814_00602	1.079e-08	64.0	COG1368@1|root,COG1368@2|Bacteria,1V8EX@1239|Firmicutes,24KF8@186801|Clostridia,3WMJ8@541000|Ruminococcaceae	186801|Clostridia	M	CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
GDHHQS1_k127_13058661_1	744872.Spica_2052	1.362e-49	183.0	COG2095@1|root,COG2095@2|Bacteria,2J7MT@203691|Spirochaetes	203691|Spirochaetes	U	membrane	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
GDHHQS1_k127_13058661_0	1519464.HY22_00065	7.297e-115	379.0	COG1171@1|root,COG1171@2|Bacteria	2|Bacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
GDHHQS1_k127_13058661_3	1408311.JNJM01000010_gene1084	8.908e-20	103.0	COG1373@1|root,COG1373@2|Bacteria,1TQ8Z@1239|Firmicutes,24A83@186801|Clostridia,2PT8M@265975|Oribacterium	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
GDHHQS1_k127_13058661_6	794903.OPIT5_16195	1.101e-15	86.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
GDHHQS1_k127_13058661_5	794903.OPIT5_16195	5.932e-18	89.0	COG2253@1|root,COG2253@2|Bacteria	2|Bacteria	V	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
GDHHQS1_k127_13058661_2	59374.Fisuc_1504	1.19e-36	145.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0004358,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00619,ko:K00930,ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226	AA_kinase,Acetyltransf_1
GDHHQS1_k127_13060615_0	443143.GM18_1405	1.246e-117	400.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
GDHHQS1_k127_13120364_3	1122917.KB899671_gene4398	4.586e-22	100.0	COG0673@1|root,COG0673@2|Bacteria,1TT9N@1239|Firmicutes,4I9F2@91061|Bacilli,271FQ@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_13120364_4	313628.LNTAR_20648	8.726e-09	57.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
GDHHQS1_k127_13120364_5	1123072.AUDH01000018_gene2709	0.0003061	48.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria	1224|Proteobacteria	L	Transposase	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
GDHHQS1_k127_13120364_2	1041147.AUFB01000024_gene5164	2.339e-34	139.0	COG4300@1|root,COG4300@2|Bacteria,1N2FB@1224|Proteobacteria,2VEDF@28211|Alphaproteobacteria,4BEBV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Cadmium resistance transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cad
GDHHQS1_k127_13120364_0	1499967.BAYZ01000147_gene684	7.669e-101	349.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
GDHHQS1_k127_13120364_1	1499967.BAYZ01000147_gene686	1.267e-61	219.0	COG1063@1|root,COG1063@2|Bacteria,2NQVE@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	ydjL	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_13137112_3	158190.SpiGrapes_1081	4.633e-117	406.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
GDHHQS1_k127_13137112_5	471853.Bcav_3352	3.574e-71	258.0	COG1820@1|root,COG1820@2|Bacteria,2HKTU@201174|Actinobacteria	201174|Actinobacteria	G	Amidohydrolase family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
GDHHQS1_k127_13137112_8	573413.Spirs_0552	7.62e-50	190.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,2J8E5@203691|Spirochaetes	203691|Spirochaetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
GDHHQS1_k127_13137112_4	744872.Spica_2327	1.018e-75	274.0	COG2208@1|root,COG5002@1|root,COG2208@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GGDEF,HATPase_c_2,HTH_Crp_2,HisKA,PAS,PAS_4,PAS_9,SpoIIE
GDHHQS1_k127_13137112_6	744872.Spica_2326	2.065e-64	228.0	COG0120@1|root,COG0120@2|Bacteria,2J575@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
GDHHQS1_k127_13137112_1	525904.Tter_2468	5.92e-198	647.0	COG4354@1|root,COG4354@2|Bacteria,2NQ9B@2323|unclassified Bacteria	2|Bacteria	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	-	-	-	-	-	-	-	-	-	-	DUF608,Glyco_hydr_116N
GDHHQS1_k127_13137112_7	1382356.JQMP01000004_gene175	1.821e-60	220.0	COG0179@1|root,COG0179@2|Bacteria,2G6H8@200795|Chloroflexi,27YS7@189775|Thermomicrobia	189775|Thermomicrobia	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
GDHHQS1_k127_13137112_2	1185876.BN8_03164	1.155e-131	434.0	COG2942@1|root,COG2942@2|Bacteria,4NHTQ@976|Bacteroidetes,47KVQ@768503|Cytophagia	976|Bacteroidetes	G	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	-	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
GDHHQS1_k127_13137112_0	889378.Spiaf_0670	2.866e-216	676.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
GDHHQS1_k127_13196217_0	1123267.JONN01000001_gene1238	5.179e-202	654.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
GDHHQS1_k127_13212647_0	1128421.JAGA01000004_gene2560	1.942e-124	416.0	COG2252@1|root,COG2252@2|Bacteria,2NNZ2@2323|unclassified Bacteria	2|Bacteria	S	Permease family	yjcD	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
GDHHQS1_k127_1323849_29	573413.Spirs_4056	2.286e-50	187.0	COG1466@1|root,COG1466@2|Bacteria,2J6PN@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
GDHHQS1_k127_1323849_32	1453505.JASY01000010_gene3939	5.76e-27	123.0	2CCQF@1|root,2Z7QP@2|Bacteria,4NK8W@976|Bacteroidetes,1IN7H@117743|Flavobacteriia,2NYAC@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1323849_35	525904.Tter_2554	1.365e-06	58.0	COG4635@1|root,COG4635@2|Bacteria	2|Bacteria	CH	menaquinone-dependent protoporphyrinogen oxidase activity	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
GDHHQS1_k127_1323849_1	1499967.BAYZ01000032_gene1132	3.155e-232	743.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
GDHHQS1_k127_1323849_0	1499967.BAYZ01000032_gene1131	0.0	1483.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
GDHHQS1_k127_1323849_5	903818.KI912268_gene2682	1.936e-145	469.0	COG1897@1|root,COG1897@2|Bacteria,3Y6RE@57723|Acidobacteria	57723|Acidobacteria	E	Homoserine O-succinyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	HTS
GDHHQS1_k127_1323849_8	1499967.BAYZ01000181_gene4480	2.048e-134	439.0	COG0413@1|root,COG0413@2|Bacteria,2NP1G@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
GDHHQS1_k127_1323849_3	1499967.BAYZ01000180_gene4413	1.149e-168	567.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1323849_34	1123226.KB899282_gene3069	2.114e-08	67.0	COG3828@1|root,COG3828@2|Bacteria,1V3QJ@1239|Firmicutes,4HX2W@91061|Bacilli,26S1A@186822|Paenibacillaceae	91061|Bacilli	S	Glycosyl hydrolase	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
GDHHQS1_k127_1323849_31	1509405.GV67_20385	2.64e-27	125.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2U1Y7@28211|Alphaproteobacteria,4BA95@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_1323849_6	1219084.AP014508_gene244	4.69e-141	467.0	COG2211@1|root,COG2211@2|Bacteria,2GCKM@200918|Thermotogae	200918|Thermotogae	G	MFS/sugar transport protein	-	-	-	ko:K16210	-	-	-	-	ko00000,ko02000	2.A.2.5	-	-	MFS_2
GDHHQS1_k127_1323849_22	768706.Desor_2181	3.928e-66	235.0	2ASZS@1|root,31IFG@2|Bacteria,1V50D@1239|Firmicutes,24PRN@186801|Clostridia,262PV@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1323849_2	537013.CLOSTMETH_02949	2.519e-208	680.0	COG1196@1|root,COG1874@1|root,COG3408@1|root,COG5434@1|root,COG1196@2|Bacteria,COG1874@2|Bacteria,COG3408@2|Bacteria,COG5434@2|Bacteria,1UYMK@1239|Firmicutes,24YZX@186801|Clostridia	2|Bacteria	G	FIVAR domain	sca1	-	3.2.1.23,3.2.1.4	ko:K01179,ko:K01190,ko:K03931,ko:K12308,ko:K21449	ko00052,ko00500,ko00511,ko00600,ko01100,map00052,map00500,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114,R06200,R11307,R11308	RC00049,RC00452	ko00000,ko00001,ko01000,ko02000	1.B.40.2	GH5,GH63,GH9	-	F5_F8_type_C,FIVAR,Pectate_lyase_3,RicinB_lectin_2
GDHHQS1_k127_1323849_21	574087.Acear_0944	2.456e-67	245.0	COG3836@1|root,COG3836@2|Bacteria,1UZZG@1239|Firmicutes,24DTX@186801|Clostridia	186801|Clostridia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52,4.1.2.53	ko:K02510,ko:K12660	ko00051,ko00350,ko01120,map00051,map00350,map01120	-	R01645,R01647,R02261	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
GDHHQS1_k127_1323849_25	1385514.N782_15215	1.776e-60	221.0	COG1082@1|root,COG1082@2|Bacteria,1UITG@1239|Firmicutes,4HFIC@91061|Bacilli	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_1323849_28	1128421.JAGA01000001_gene2050	2.173e-52	190.0	COG3822@1|root,COG3822@2|Bacteria,2NQJ1@2323|unclassified Bacteria	2|Bacteria	S	Pfam:DUF1498	Z012_00995	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
GDHHQS1_k127_1323849_13	588581.Cpap_1209	2.124e-108	357.0	COG0395@1|root,COG0395@2|Bacteria,1TSYB@1239|Firmicutes,24AKM@186801|Clostridia,3WIYF@541000|Ruminococcaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10194	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	BPD_transp_1
GDHHQS1_k127_1323849_14	1195236.CTER_3503	7.042e-100	334.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,248DR@186801|Clostridia,3WISE@541000|Ruminococcaceae	186801|Clostridia	P	carbohydrate ABC transporter membrane protein 1 CUT1 family	-	-	-	ko:K02025,ko:K10193	ko02010,map02010	M00202,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.11	-	-	BPD_transp_1
GDHHQS1_k127_1323849_16	632292.Calhy_0140	7.288e-87	303.0	COG1653@1|root,COG1653@2|Bacteria,1V0P9@1239|Firmicutes,25BEX@186801|Clostridia	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10192	ko02010,map02010	M00202	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.11	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_1323849_19	332101.JIBU02000020_gene2075	3.518e-77	281.0	COG2017@1|root,COG2017@2|Bacteria,1TS6R@1239|Firmicutes,24E8S@186801|Clostridia	186801|Clostridia	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
GDHHQS1_k127_1323849_17	1382306.JNIM01000001_gene2724	7.361e-81	282.0	COG1028@1|root,COG1028@2|Bacteria,2G8K5@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.5.1.33	ko:K00059,ko:K03793	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS1_k127_1323849_24	644966.Tmar_1095	5.026e-61	227.0	COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,247Q4@186801|Clostridia	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GDHHQS1_k127_1323849_30	1235279.C772_01413	1.612e-33	139.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,4HFMP@91061|Bacilli,26E5B@186818|Planococcaceae	91061|Bacilli	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
GDHHQS1_k127_1323849_23	1423321.AS29_18645	1.222e-64	233.0	COG3386@1|root,COG3386@2|Bacteria,1V1TK@1239|Firmicutes,4HG0A@91061|Bacilli,1ZAVX@1386|Bacillus	91061|Bacilli	G	SMP-30/Gluconolaconase/LRE-like region	yvrE	GO:0003674,GO:0003824,GO:0004341,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016051,GO:0016053,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019853,GO:0042364,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:1901576	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
GDHHQS1_k127_1323849_12	665571.STHERM_c18190	6.413e-122	401.0	COG0673@1|root,COG0673@2|Bacteria,2J5J5@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_1323849_9	644282.Deba_1323	3.679e-133	448.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_1323849_4	573413.Spirs_4068	1.062e-161	548.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
GDHHQS1_k127_1323849_18	1123274.KB899414_gene3682	3.044e-80	286.0	COG4733@1|root,COG4733@2|Bacteria,2JBHZ@203691|Spirochaetes	203691|Spirochaetes	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,fn3
GDHHQS1_k127_1323849_15	744872.Spica_2727	1.034e-89	336.0	COG0457@1|root,COG0457@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
GDHHQS1_k127_1323849_11	573413.Spirs_4078	3.14e-123	401.0	COG1639@1|root,COG1639@2|Bacteria,2J74B@203691|Spirochaetes	203691|Spirochaetes	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
GDHHQS1_k127_1323849_7	1123274.KB899414_gene3685	6.71e-139	447.0	COG1235@1|root,COG1235@2|Bacteria,2J6YX@203691|Spirochaetes	203691|Spirochaetes	S	Beta-lactamase superfamily domain	elaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
GDHHQS1_k127_1323849_20	665571.STHERM_c19020	3.169e-73	252.0	COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes	203691|Spirochaetes	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
GDHHQS1_k127_1323849_27	639282.DEFDS_0706	2.014e-53	198.0	COG0672@1|root,COG0672@2|Bacteria,2GGKP@200930|Deferribacteres	200930|Deferribacteres	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
GDHHQS1_k127_1323849_26	234267.Acid_5268	1.311e-54	194.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS1_k127_1323849_10	545694.TREPR_2079	3.382e-131	469.0	COG2911@1|root,COG2911@2|Bacteria,2JBJG@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
GDHHQS1_k127_13239945_4	1122918.KB907247_gene4929	8.669e-29	121.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4HGM6@91061|Bacilli,26V6W@186822|Paenibacillaceae	91061|Bacilli	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
GDHHQS1_k127_13239945_1	926569.ANT_27070	2.251e-208	678.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2G6IW@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GDHHQS1_k127_13239945_2	926569.ANT_27060	3.152e-94	315.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_13239945_3	926569.ANT_27050	3.482e-64	225.0	COG1695@1|root,COG1695@2|Bacteria,2G9N5@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
GDHHQS1_k127_13239945_0	1123274.KB899435_gene1309	0.0	1131.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
GDHHQS1_k127_13239945_5	297246.lpp1558	1.793e-08	58.0	COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_29,rve
GDHHQS1_k127_13242488_9	1307761.L21SP2_0140	5.462e-96	324.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
GDHHQS1_k127_13242488_1	573413.Spirs_3670	5.151e-187	602.0	COG3437@1|root,COG3437@2|Bacteria,2JBCG@203691|Spirochaetes	203691|Spirochaetes	KT	COGs COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,PAS_9
GDHHQS1_k127_13242488_28	1122963.AUHB01000010_gene1568	4.917e-18	98.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,36Y67@31993|Methylocystaceae	28211|Alphaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal
GDHHQS1_k127_13242488_18	545694.TREPR_1276	5.179e-46	169.0	COG0764@1|root,COG0764@2|Bacteria,2J7PK@203691|Spirochaetes	203691|Spirochaetes	I	dehydratase	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
GDHHQS1_k127_13242488_21	665571.STHERM_c08560	2.589e-38	149.0	COG0511@1|root,COG0511@2|Bacteria,2J83W@203691|Spirochaetes	203691|Spirochaetes	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
GDHHQS1_k127_13242488_19	545694.TREPR_1270	2.369e-42	164.0	COG0439@1|root,COG0439@2|Bacteria,2J5D2@203691|Spirochaetes	203691|Spirochaetes	I	Biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
GDHHQS1_k127_13242488_4	665571.STHERM_c08570	2.396e-131	426.0	COG0439@1|root,COG0439@2|Bacteria,2J5D2@203691|Spirochaetes	203691|Spirochaetes	I	Biotin carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
GDHHQS1_k127_13242488_10	665571.STHERM_c08580	6.558e-94	324.0	COG0777@1|root,COG0777@2|Bacteria,2J5W0@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
GDHHQS1_k127_13242488_8	665571.STHERM_c08590	4.758e-98	344.0	COG0825@1|root,COG0825@2|Bacteria,2J5PA@203691|Spirochaetes	203691|Spirochaetes	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
GDHHQS1_k127_13242488_25	889378.Spiaf_0442	1.196e-24	108.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0070482,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_13242488_24	1499967.BAYZ01000050_gene2839	7.197e-27	113.0	COG0640@1|root,COG0640@2|Bacteria,2NQ13@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	3.6.4.12	ko:K03655,ko:K03892	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	HTH_20,HTH_5
GDHHQS1_k127_13242488_2	1499967.BAYZ01000050_gene2840	4.207e-180	574.0	COG0701@1|root,COG0701@2|Bacteria,2NP6A@2323|unclassified Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
GDHHQS1_k127_13242488_29	269797.Mbar_A0155	5.8e-18	89.0	COG0526@1|root,arCOG02713@2157|Archaea,2Y18H@28890|Euryarchaeota,2NA1S@224756|Methanomicrobia	224756|Methanomicrobia	O	Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
GDHHQS1_k127_13242488_26	387092.NIS_0087	4.906e-22	97.0	COG1018@1|root,COG1146@1|root,COG1018@2|Bacteria,COG1146@2|Bacteria,1REP4@1224|Proteobacteria,43BUF@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Oxidoreductase FAD-binding domain	-	-	1.17.1.1,1.18.1.7	ko:K00523,ko:K14581	ko00520,ko00624,ko00626,ko00627,ko00633,ko00642,ko01100,ko01120,ko01220,map00520,map00624,map00626,map00627,map00633,map00642,map01100,map01120,map01220	M00534,M00638	R02968,R03391,R03392,R05422,R05423,R05424,R05425,R05426,R05427,R06909,R06930,R06937,R07704,R07706,R07709,R07710,R09159,R09233	RC00091,RC00098,RC00157,RC00230,RC00274,RC00275,RC00490,RC01376,RC01377,RC01801	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
GDHHQS1_k127_13242488_0	1047013.AQSP01000092_gene323	2.065e-187	599.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
GDHHQS1_k127_13242488_32	646529.Desaci_2271	4.585e-09	63.0	arCOG03368@1|root,331XD@2|Bacteria,1VHY0@1239|Firmicutes,24SSZ@186801|Clostridia,262UP@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13242488_30	1336233.JAEH01000040_gene4257	3.336e-14	82.0	2DPAK@1|root,33193@2|Bacteria,1NDU6@1224|Proteobacteria,1RTIG@1236|Gammaproteobacteria,2QCZV@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13242488_15	1304885.AUEY01000001_gene3203	1.081e-50	188.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
GDHHQS1_k127_13242488_6	926550.CLDAP_40590	6.745e-105	356.0	COG0535@1|root,COG2002@1|root,COG0535@2|Bacteria,COG2002@2|Bacteria,2G75Y@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
GDHHQS1_k127_13242488_17	1511.CLOST_0766	1.047e-47	176.0	COG0701@1|root,COG0701@2|Bacteria,1V5T4@1239|Firmicutes,24HM7@186801|Clostridia	186801|Clostridia	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
GDHHQS1_k127_13242488_16	158189.SpiBuddy_1068	1.381e-48	187.0	COG0701@1|root,COG0701@2|Bacteria,2JAEM@203691|Spirochaetes	203691|Spirochaetes	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
GDHHQS1_k127_13242488_3	665571.STHERM_c20440	7.533e-167	533.0	COG0156@1|root,COG0156@2|Bacteria,2J615@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS1_k127_13242488_13	545694.TREPR_0230	3.694e-66	237.0	COG0785@1|root,COG0785@2|Bacteria,2J640@203691|Spirochaetes	203691|Spirochaetes	O	cytochrome c biogenesis protein	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
GDHHQS1_k127_13242488_20	665571.STHERM_c08610	8.49e-41	161.0	COG0526@1|root,COG0526@2|Bacteria,2J8ET@203691|Spirochaetes	203691|Spirochaetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
GDHHQS1_k127_13242488_27	573413.Spirs_1504	2.114e-19	97.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	3.4.11.19	ko:K01266,ko:K07052	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abi
GDHHQS1_k127_13242488_5	1123274.KB899409_gene438	8.607e-121	398.0	COG5581@1|root,COG5581@2|Bacteria,2J6AM@203691|Spirochaetes	203691|Spirochaetes	M	Type IV pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
GDHHQS1_k127_13242488_12	573413.Spirs_1506	2.378e-78	276.0	COG1413@1|root,COG1413@2|Bacteria,2J7D8@203691|Spirochaetes	203691|Spirochaetes	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13242488_23	545694.TREPR_3484	1.94e-29	134.0	COG0658@1|root,COG0658@2|Bacteria,2J6H9@203691|Spirochaetes	203691|Spirochaetes	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence
GDHHQS1_k127_13242488_14	907348.TresaDRAFT_0382	6.995e-58	219.0	COG0030@1|root,COG0030@2|Bacteria,2J65T@203691|Spirochaetes	203691|Spirochaetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
GDHHQS1_k127_13242488_7	665571.STHERM_c08670	3.775e-103	346.0	COG0329@1|root,COG0329@2|Bacteria,2J5J6@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
GDHHQS1_k127_13242488_11	665571.STHERM_c08680	1.133e-87	296.0	COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
GDHHQS1_k127_13242488_22	158190.SpiGrapes_2966	2.195e-34	132.0	COG0280@1|root,COG0280@2|Bacteria,2J5DS@203691|Spirochaetes	203691|Spirochaetes	C	phosphate acetyltransferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
GDHHQS1_k127_13311220_4	665571.STHERM_c08130	3.613e-36	142.0	COG0399@1|root,COG0399@2|Bacteria,2J62G@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_13311220_1	744872.Spica_1447	6.34e-200	635.0	COG1086@1|root,COG1086@2|Bacteria,2J5C2@203691|Spirochaetes	203691|Spirochaetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,CoA_binding_3,Polysacc_synt_2
GDHHQS1_k127_13311220_5	744872.Spica_1444	2.634e-09	70.0	COG0797@1|root,COG0797@2|Bacteria,2J7K2@203691|Spirochaetes	203691|Spirochaetes	M	Sporulation and cell division repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
GDHHQS1_k127_13311220_0	1123274.KB899409_gene603	1.973e-246	781.0	COG0272@1|root,COG0272@2|Bacteria,2J57Q@203691|Spirochaetes	203691|Spirochaetes	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
GDHHQS1_k127_13311220_2	1259795.ARJK01000003_gene690	8.584e-117	387.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,42FG6@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
GDHHQS1_k127_13311220_3	309798.COPRO5265_0858	1.057e-76	265.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,42F9A@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
GDHHQS1_k127_13371998_0	525904.Tter_1474	1.525e-180	575.0	COG0667@1|root,COG0673@1|root,COG0667@2|Bacteria,COG0673@2|Bacteria,2NP86@2323|unclassified Bacteria	2|Bacteria	C	Oxidoreductase family, NAD-binding Rossmann fold	strT	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,GFO_IDH_MocA
GDHHQS1_k127_13371998_1	497964.CfE428DRAFT_3173	5.905e-85	295.0	COG0673@1|root,COG0673@2|Bacteria,46TMF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_13371998_2	509635.N824_29540	8.907e-10	63.0	COG0793@1|root,COG0793@2|Bacteria,4NIS9@976|Bacteroidetes,1ISHT@117747|Sphingobacteriia	976|Bacteroidetes	M	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
GDHHQS1_k127_13387509_6	1499967.BAYZ01000123_gene2489	8.046e-06	56.0	2ESWM@1|root,33KEZ@2|Bacteria	2|Bacteria	S	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_13387509_5	1157637.KB892132_gene3646	3.624e-12	77.0	COG3568@1|root,COG3568@2|Bacteria,2GNC4@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.4.12,3.1.4.3	ko:K01114,ko:K01117	ko00562,ko00564,ko00565,ko00600,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map00600,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R02541,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Exo_endo_phos
GDHHQS1_k127_13387509_4	1121104.AQXH01000001_gene1190	1.751e-15	84.0	29E7I@1|root,3015I@2|Bacteria,4NNFG@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
GDHHQS1_k127_13387509_1	760011.Spico_0166	9.538e-97	351.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
GDHHQS1_k127_13387509_2	1382304.JNIL01000001_gene1720	1.235e-51	187.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,4HIGJ@91061|Bacilli,27A47@186823|Alicyclobacillaceae	91061|Bacilli	H	Dihydrofolate reductase	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
GDHHQS1_k127_13387509_0	1429916.X566_00885	3.768e-131	429.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,3JV7Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
GDHHQS1_k127_13387509_3	706587.Desti_1075	8.152e-22	99.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
GDHHQS1_k127_13390071_0	530564.Psta_3290	5.634e-103	350.0	COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
GDHHQS1_k127_13390071_3	1122138.AQUZ01000012_gene6041	1.162e-43	181.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13390071_2	7213.XP_004532928.1	3.478e-45	179.0	COG1970@1|root,2S7M9@2759|Eukaryota,398Y7@33154|Opisthokonta,3BVD1@33208|Metazoa,3DB59@33213|Bilateria,4233F@6656|Arthropoda,3SRU1@50557|Insecta	33208|Metazoa	M	Large-conductance mechanosensitive channel, MscL	-	-	-	-	-	-	-	-	-	-	-	-	MscL
GDHHQS1_k127_13390071_4	748727.CLJU_c17460	2.373e-21	109.0	COG2909@1|root,COG2909@2|Bacteria	2|Bacteria	K	trisaccharide binding	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	Abhydrolase_1,GerE
GDHHQS1_k127_13390071_1	871963.Desdi_0372	4.604e-62	237.0	COG0348@1|root,COG0348@2|Bacteria,1UVRB@1239|Firmicutes,25I6A@186801|Clostridia,266AF@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_9
GDHHQS1_k127_13400734_7	1111479.AXAR01000002_gene1813	5.222e-21	101.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,4HB9E@91061|Bacilli	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
GDHHQS1_k127_13400734_3	1349822.NSB1T_03160	4.108e-98	362.0	COG3408@1|root,COG3408@2|Bacteria,4NIK8@976|Bacteroidetes,2FMD2@200643|Bacteroidia,22YSR@171551|Porphyromonadaceae	976|Bacteroidetes	G	Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63,Trehalase
GDHHQS1_k127_13400734_5	610130.Closa_1783	3.735e-76	280.0	COG2972@1|root,COG2972@2|Bacteria,1VSIQ@1239|Firmicutes,24F8A@186801|Clostridia,223UQ@1506553|Lachnoclostridium	186801|Clostridia	T	Cache domain	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
GDHHQS1_k127_13400734_6	743719.PaelaDRAFT_5881	1.125e-39	171.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HI3Z@91061|Bacilli,274BP@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
GDHHQS1_k127_13400734_2	665956.HMPREF1032_03803	6.555e-102	349.0	COG1653@1|root,COG1653@2|Bacteria,1UYEX@1239|Firmicutes,24FEV@186801|Clostridia,3WQFW@541000|Ruminococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
GDHHQS1_k127_13400734_4	755731.Clo1100_3085	1.839e-90	309.0	COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,25C59@186801|Clostridia,36WPU@31979|Clostridiaceae	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_13400734_1	610130.Closa_1787	2.286e-106	367.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,25C5D@186801|Clostridia,21ZV4@1506553|Lachnoclostridium	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_13400734_0	1226325.HMPREF1548_00162	1.349e-128	423.0	COG1053@1|root,COG1053@2|Bacteria,1UM4U@1239|Firmicutes,24AI4@186801|Clostridia,36DHI@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
GDHHQS1_k127_13453311_0	794846.AJQU01000111_gene3208	7.388e-05	50.0	COG0596@1|root,COG0596@2|Bacteria,1Q47F@1224|Proteobacteria,2U3WB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
GDHHQS1_k127_13461745_6	1313172.YM304_34050	0.0002577	55.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14194	ko05150,map05150	-	-	-	ko00000,ko00001	-	-	-	Cadherin,DUF11,GSu_C4xC__C2xCH,SdrD_B
GDHHQS1_k127_13461745_1	177439.DP1963	6e-78	269.0	COG3121@1|root,COG3121@2|Bacteria,1RCF5@1224|Proteobacteria,42Y7D@68525|delta/epsilon subdivisions,2WTKP@28221|Deltaproteobacteria,2MMT2@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Chaperone	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13461745_3	471854.Dfer_1481	2.465e-13	80.0	2EK1V@1|root,33DSB@2|Bacteria,4NZR8@976|Bacteroidetes,47WBP@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13461745_5	172045.KS04_10305	1.023e-07	62.0	2DZDV@1|root,33VF4@2|Bacteria,4P2CD@976|Bacteroidetes,1I8MQ@117743|Flavobacteriia,34RH1@308865|Elizabethkingia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13461745_0	1121346.KB899808_gene3590	1.484e-99	345.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4ISHD@91061|Bacilli,26SCF@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl transferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	F5_F8_type_C,GT87,PMT,PMT_2,PMT_4TMC
GDHHQS1_k127_13461745_2	1229780.BN381_410024	1.88e-68	262.0	COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
GDHHQS1_k127_13461745_4	1268072.PSAB_02965	1.609e-09	68.0	COG4346@1|root,COG5650@1|root,COG4346@2|Bacteria,COG5650@2|Bacteria,1TSHX@1239|Firmicutes,4ISHD@91061|Bacilli,26SCF@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl transferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	F5_F8_type_C,GT87,PMT,PMT_2,PMT_4TMC
GDHHQS1_k127_13465947_6	1047013.AQSP01000140_gene2513	3.146e-64	233.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
GDHHQS1_k127_13465947_1	2325.TKV_c01910	4.077e-108	362.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,42FWZ@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	ko:K02574	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_5
GDHHQS1_k127_13465947_8	2325.TKV_c01900	8.007e-54	200.0	COG0348@1|root,COG0348@2|Bacteria,1V8RW@1239|Firmicutes,24JXS@186801|Clostridia,42GUZ@68295|Thermoanaerobacterales	186801|Clostridia	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13465947_0	439235.Dalk_3029	1.51e-315	989.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WM1R@28221|Deltaproteobacteria,2MID5@213118|Desulfobacterales	28221|Deltaproteobacteria	KL	SNF2 Helicase protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
GDHHQS1_k127_13465947_9	221027.JO40_05570	1.656e-45	173.0	28N6T@1|root,2ZBBM@2|Bacteria,2JA8B@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13465947_7	926569.ANT_17620	2.128e-58	209.0	COG1309@1|root,COG1309@2|Bacteria,2G7DR@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
GDHHQS1_k127_13465947_3	926569.ANT_17630	1.453e-91	331.0	COG0451@1|root,COG0451@2|Bacteria,2G84M@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
GDHHQS1_k127_13465947_11	398511.BpOF4_14470	4.369e-33	149.0	COG0300@1|root,COG0300@2|Bacteria,1TSJ3@1239|Firmicutes,4HDU5@91061|Bacilli,1ZBRZ@1386|Bacillus	91061|Bacilli	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	yqjQ	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
GDHHQS1_k127_13465947_2	1382304.JNIL01000001_gene3184	1.631e-103	351.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,4HC1G@91061|Bacilli	91061|Bacilli	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS1_k127_13465947_12	697281.Mahau_2290	1.58e-27	128.0	COG0407@1|root,COG0407@2|Bacteria,1V47M@1239|Firmicutes,24I1B@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_13465947_10	370438.PTH_2838	1.312e-42	171.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,260W6@186807|Peptococcaceae	186801|Clostridia	G	Fructose-1,6-bisphosphate aldolase, class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
GDHHQS1_k127_13465947_5	886293.Sinac_5399	2.417e-65	248.0	COG0524@1|root,COG0524@2|Bacteria,2IX8I@203682|Planctomycetes	203682|Planctomycetes	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
GDHHQS1_k127_13465947_4	697281.Mahau_0888	2.372e-68	250.0	COG3822@1|root,COG3822@2|Bacteria,1V1ZU@1239|Firmicutes,24ENY@186801|Clostridia,42G5P@68295|Thermoanaerobacterales	186801|Clostridia	S	D-lyxose ketol-isomerase	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
GDHHQS1_k127_13487832_5	1125863.JAFN01000001_gene2916	1.005e-07	55.0	COG0347@1|root,COG0347@2|Bacteria,1NPUT@1224|Proteobacteria,42WWB@68525|delta/epsilon subdivisions,2WTEG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13487832_0	744872.Spica_2723	1.539e-178	574.0	COG0579@1|root,COG0579@2|Bacteria,2J61Q@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
GDHHQS1_k127_13487832_1	889378.Spiaf_0323	2.101e-140	458.0	COG0446@1|root,COG0446@2|Bacteria,2J5ZG@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulfide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
GDHHQS1_k127_13487832_3	748224.HMPREF9436_02049	2.486e-23	105.0	COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,3WKTY@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
GDHHQS1_k127_13487832_2	889378.Spiaf_0246	2.925e-113	375.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
GDHHQS1_k127_13487832_4	1480694.DC28_06515	6.531e-11	63.0	COG0331@1|root,COG0331@2|Bacteria,2J5E6@203691|Spirochaetes	203691|Spirochaetes	I	Malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
GDHHQS1_k127_13623830_2	1307761.L21SP2_1931	1.494e-07	61.0	COG0587@1|root,COG0587@2|Bacteria,2J5DA@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase	-	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
GDHHQS1_k127_13623830_0	1480694.DC28_08450	7.099e-150	484.0	COG0686@1|root,COG0686@2|Bacteria,2J6R2@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
GDHHQS1_k127_13623830_1	545694.TREPR_3857	5.392e-33	147.0	COG0457@1|root,COG0457@2|Bacteria,2J8BT@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
GDHHQS1_k127_1366027_3	573413.Spirs_0003	2.676e-64	225.0	COG0592@1|root,COG0592@2|Bacteria,2J629@203691|Spirochaetes	203691|Spirochaetes	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
GDHHQS1_k127_1366027_2	1123274.KB899423_gene1595	8.267e-91	312.0	COG1195@1|root,COG1195@2|Bacteria,2J5MP@203691|Spirochaetes	203691|Spirochaetes	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
GDHHQS1_k127_1366027_8	744872.Spica_0004	4.408e-15	80.0	COG5512@1|root,COG5512@2|Bacteria,2J8RK@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
GDHHQS1_k127_1366027_6	545695.TREAZ_2143	1.839e-20	92.0	COG0230@1|root,COG0230@2|Bacteria,2J8S9@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
GDHHQS1_k127_1366027_10	1120746.CCNL01000007_gene446	1.554e-06	55.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
GDHHQS1_k127_1366027_5	589865.DaAHT2_2555	3.087e-24	109.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,42VNC@68525|delta/epsilon subdivisions,2WRIM@28221|Deltaproteobacteria,2MM0C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
GDHHQS1_k127_1366027_0	573413.Spirs_0008	8.77e-116	397.0	COG0706@1|root,COG0706@2|Bacteria,2J5HA@203691|Spirochaetes	203691|Spirochaetes	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
GDHHQS1_k127_1366027_4	545694.TREPR_0502	1.453e-42	179.0	COG1847@1|root,COG1847@2|Bacteria,2J5S0@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
GDHHQS1_k127_1366027_9	864051.BurJ1DRAFT_4231	8.982e-08	64.0	COG2331@1|root,COG2331@2|Bacteria,1PVEY@1224|Proteobacteria,2VYJG@28216|Betaproteobacteria,1KP71@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
GDHHQS1_k127_1366027_1	1210884.HG799466_gene12816	1.34e-101	374.0	COG2203@1|root,COG3852@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_1366027_7	640081.Dsui_0966	1.923e-19	100.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VMK6@28216|Betaproteobacteria,2KURB@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
GDHHQS1_k127_1367996_38	9685.ENSFCAP00000021808	4.763e-06	59.0	COG0666@1|root,KOG0504@2759|Eukaryota,39JVB@33154|Opisthokonta,3BJQ0@33208|Metazoa,3CXAM@33213|Bilateria,48AB5@7711|Chordata,490N8@7742|Vertebrata,3JDE8@40674|Mammalia,3EPGU@33554|Carnivora	33208|Metazoa	S	ankyrin repeat and SOCS	ASB3	GO:0000151,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019899,GO:0031625,GO:0032446,GO:0032991,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044424,GO:0044444,GO:0044464,GO:0070647,GO:0071704,GO:0140096,GO:1901564,GO:1902494,GO:1990234	-	ko:K10325	-	-	-	-	ko00000,ko04121	-	-	-	Ank_2,Ank_3,Ank_4,SOCS_box
GDHHQS1_k127_1367996_35	860228.Ccan_12650	5.528e-19	102.0	COG0515@1|root,COG0515@2|Bacteria,4PKQ1@976|Bacteroidetes,1IKEE@117743|Flavobacteriia,1ETJM@1016|Capnocytophaga	976|Bacteroidetes	KLT	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
GDHHQS1_k127_1367996_16	744872.Spica_2494	4.554e-80	272.0	COG0740@1|root,COG0740@2|Bacteria,2J78H@203691|Spirochaetes	203691|Spirochaetes	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP-2	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
GDHHQS1_k127_1367996_12	1307761.L21SP2_2844	7.926e-91	320.0	COG0152@1|root,COG0152@2|Bacteria,2J6XZ@203691|Spirochaetes	203691|Spirochaetes	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
GDHHQS1_k127_1367996_20	573413.Spirs_3694	6.719e-55	209.0	COG3568@1|root,COG3568@2|Bacteria,2J7FP@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Endonuclease Exonuclease phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
GDHHQS1_k127_1367996_5	1480694.DC28_04025	4.368e-121	402.0	COG1364@1|root,COG1364@2|Bacteria,2J5IC@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
GDHHQS1_k127_1367996_30	889378.Spiaf_2529	4.715e-37	141.0	COG0361@1|root,COG0361@2|Bacteria,2J8JW@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
GDHHQS1_k127_1367996_25	573413.Spirs_0464	4.068e-45	166.0	COG1734@1|root,COG1734@2|Bacteria,2J7Y1@203691|Spirochaetes	203691|Spirochaetes	T	Prokaryotic dksA traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
GDHHQS1_k127_1367996_19	573413.Spirs_0466	2.137e-63	240.0	COG0491@1|root,COG0491@2|Bacteria,2J8BJ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0491 Zn-dependent hydrolase including glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS1_k127_1367996_34	768670.Calni_0597	1.321e-20	107.0	COG0220@1|root,COG0220@2|Bacteria,2GFC8@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
GDHHQS1_k127_1367996_31	573413.Spirs_0468	6.702e-35	152.0	COG0513@1|root,COG0724@1|root,COG0513@2|Bacteria,COG0724@2|Bacteria,2J7A1@203691|Spirochaetes	203691|Spirochaetes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA
GDHHQS1_k127_1367996_9	744872.Spica_0276	6.308e-103	368.0	COG2885@1|root,COG2885@2|Bacteria,2J6IG@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	tpn50	-	-	-	-	-	-	-	-	-	-	-	OmpA
GDHHQS1_k127_1367996_15	1121943.KB900003_gene2808	8.719e-83	284.0	COG0583@1|root,COG0583@2|Bacteria,1MZX1@1224|Proteobacteria,1RNFR@1236|Gammaproteobacteria,1XH35@135619|Oceanospirillales	135619|Oceanospirillales	K	transcriptional regulator	-	-	-	ko:K02521	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
GDHHQS1_k127_1367996_3	933262.AXAM01000029_gene2751	2.261e-167	550.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MIRN@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
GDHHQS1_k127_1367996_0	665571.STHERM_c14560	4.445e-282	878.0	COG0129@1|root,COG0129@2|Bacteria	2|Bacteria	EG	dihydroxy-acid dehydratase activity	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1259,iECIAI39_1322.ECIAI39_3015	ILVD_EDD
GDHHQS1_k127_1367996_32	944480.ATUV01000002_gene166	1.461e-27	121.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2M752@213113|Desulfurellales	28221|Deltaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
GDHHQS1_k127_1367996_23	1047013.AQSP01000103_gene1154	2.374e-46	175.0	COG5340@1|root,COG5340@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
GDHHQS1_k127_1367996_10	243231.GSU1368	2.88e-98	333.0	COG2253@1|root,COG2253@2|Bacteria,1NHYV@1224|Proteobacteria,43ABR@68525|delta/epsilon subdivisions,2WSTM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
GDHHQS1_k127_1367996_8	194439.CT1701	1.356e-103	344.0	COG1145@1|root,COG1145@2|Bacteria,1FENI@1090|Chlorobi	1090|Chlorobi	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
GDHHQS1_k127_1367996_24	926569.ANT_00580	8.109e-46	176.0	COG2227@1|root,COG2227@2|Bacteria,2G9HD@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
GDHHQS1_k127_1367996_26	333138.LQ50_19655	2.836e-42	169.0	COG1670@1|root,COG1670@2|Bacteria,1V4T4@1239|Firmicutes,4HGGP@91061|Bacilli,1ZGQ5@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
GDHHQS1_k127_1367996_6	1047013.AQSP01000142_gene195	4.274e-112	380.0	COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
GDHHQS1_k127_1367996_14	1173028.ANKO01000155_gene4447	7.18e-86	302.0	COG0204@1|root,COG0204@2|Bacteria,1G0U3@1117|Cyanobacteria,1H8WE@1150|Oscillatoriales	1117|Cyanobacteria	I	SMART Phospholipid glycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
GDHHQS1_k127_1367996_13	649638.Trad_2282	1.167e-90	314.0	COG1653@1|root,COG1653@2|Bacteria,1WIUT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
GDHHQS1_k127_1367996_17	926550.CLDAP_35610	3.514e-79	273.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	malF	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
GDHHQS1_k127_1367996_18	926550.CLDAP_35620	6.221e-74	264.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17242,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00206,M00207,M00491,M00600,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.39	-	-	BPD_transp_1
GDHHQS1_k127_1367996_27	1232443.BAIA02000147_gene1621	4.784e-42	165.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24R48@186801|Clostridia	186801|Clostridia	S	Creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
GDHHQS1_k127_1367996_22	665571.STHERM_c20830	1.061e-46	174.0	COG0494@1|root,COG0494@2|Bacteria,2J7P7@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
GDHHQS1_k127_1367996_4	497964.CfE428DRAFT_1536	6.176e-146	489.0	COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
GDHHQS1_k127_1367996_21	1089551.KE386572_gene3795	1.034e-49	203.0	COG1940@1|root,COG1940@2|Bacteria,1RBY5@1224|Proteobacteria,2U5ZX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
GDHHQS1_k127_1367996_7	1340493.JNIF01000003_gene2296	7.73e-108	381.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	ko:K18106	ko00040,ko01100,map00040,map01100	M00630	R07676,R10565	RC00108	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_1367996_2	744872.Spica_0671	5.108e-178	569.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
GDHHQS1_k127_1367996_11	545695.TREAZ_0773	1.946e-94	335.0	COG1305@1|root,COG1305@2|Bacteria,2J57S@203691|Spirochaetes	203691|Spirochaetes	E	IPT TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
GDHHQS1_k127_1367996_33	545695.TREAZ_0771	6.824e-24	109.0	COG5662@1|root,COG5662@2|Bacteria,2J8HF@203691|Spirochaetes	203691|Spirochaetes	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
GDHHQS1_k127_1367996_28	1480694.DC28_14910	1.281e-38	164.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS1_k127_1367996_1	665571.STHERM_c18260	7.048e-199	647.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
GDHHQS1_k127_1367996_37	59374.Fisuc_1887	9.716e-13	76.0	COG1105@1|root,COG1105@2|Bacteria	2|Bacteria	H	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.11,2.7.1.144,2.7.1.56	ko:K00882,ko:K00917,ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R02071,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
GDHHQS1_k127_13824503_6	1307761.L21SP2_1323	2.269e-34	152.0	2FE8F@1|root,34689@2|Bacteria,2J592@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13824503_0	1123274.KB899412_gene1512	6.733e-170	548.0	COG0305@1|root,COG0305@2|Bacteria,2J590@203691|Spirochaetes	203691|Spirochaetes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
GDHHQS1_k127_13824503_5	744872.Spica_1425	2.167e-40	168.0	COG0359@1|root,COG0359@2|Bacteria,2J6J9@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
GDHHQS1_k127_13824503_12	1123274.KB899412_gene1510	0.0002994	52.0	2DZ40@1|root,34CCA@2|Bacteria,2J8AY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
GDHHQS1_k127_13824503_9	1125699.HMPREF9194_01138	1.815e-26	114.0	COG0238@1|root,COG0238@2|Bacteria,2J8ZY@203691|Spirochaetes	203691|Spirochaetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
GDHHQS1_k127_13824503_3	545694.TREPR_2684	1.415e-43	164.0	COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
GDHHQS1_k127_13824503_10	744872.Spica_1429	1.483e-12	71.0	COG0360@1|root,COG0360@2|Bacteria,2J88X@203691|Spirochaetes	203691|Spirochaetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
GDHHQS1_k127_13824503_11	889378.Spiaf_2000	3.731e-06	55.0	28Z99@1|root,2ZM16@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_13824503_7	1410609.JHVB01000001_gene2335	1.375e-30	123.0	COG0261@1|root,COG0261@2|Bacteria,2J7PP@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
GDHHQS1_k127_13824503_8	1032480.MLP_36150	5.395e-28	114.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4DRNG@85009|Propionibacteriales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
GDHHQS1_k127_13824503_1	744872.Spica_0785	4.815e-110	367.0	COG0536@1|root,COG0536@2|Bacteria,2J5QY@203691|Spirochaetes	203691|Spirochaetes	C	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1,Radical_SAM
GDHHQS1_k127_13824503_4	665571.STHERM_c10300	6.365e-41	169.0	COG1057@1|root,COG1057@2|Bacteria,2J65I@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
GDHHQS1_k127_13824503_2	1123274.KB899415_gene2423	1.618e-71	258.0	COG1316@1|root,COG1316@2|Bacteria,2J57I@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
GDHHQS1_k127_1390698_2	545694.TREPR_0999	2.3e-52	202.0	COG0739@1|root,COG0739@2|Bacteria,2J7J7@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
GDHHQS1_k127_1390698_0	744872.Spica_1970	6.793e-173	584.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
GDHHQS1_k127_1390698_1	665571.STHERM_c06520	2.117e-141	461.0	COG0213@1|root,COG0213@2|Bacteria,2J607@203691|Spirochaetes	203691|Spirochaetes	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
GDHHQS1_k127_13979592_3	290397.Adeh_1566	1.377e-06	60.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1N3ZM@1224|Proteobacteria,42TUU@68525|delta/epsilon subdivisions,2WQ8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KP	PFAM iron dependent repressor	ideR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
GDHHQS1_k127_13979592_0	573370.DMR_40970	3.448e-139	471.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42PVA@68525|delta/epsilon subdivisions,2WJ10@28221|Deltaproteobacteria,2MF67@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Nucleoside recognition	feoB-1	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
GDHHQS1_k127_13979592_2	903818.KI912268_gene2154	7.77e-26	112.0	COG0735@1|root,COG0735@2|Bacteria,3Y5IN@57723|Acidobacteria	57723|Acidobacteria	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
GDHHQS1_k127_13979592_1	1007103.AFHW01000139_gene1443	3.368e-64	249.0	COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,1V1JU@1239|Firmicutes,4HFW5@91061|Bacilli,26UQX@186822|Paenibacillaceae	91061|Bacilli	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
GDHHQS1_k127_13988436_1	1379270.AUXF01000002_gene1290	5.619e-19	96.0	COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
GDHHQS1_k127_13988436_0	247634.GPB2148_1480	1.104e-36	147.0	COG1468@1|root,COG1468@2|Bacteria,1QW0M@1224|Proteobacteria,1RS6B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
GDHHQS1_k127_13991400_7	1469245.JFBG01000097_gene1355	1.68e-14	76.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_13991400_2	1121405.dsmv_3501	3.425e-86	297.0	COG1801@1|root,COG1801@2|Bacteria,1MXIQ@1224|Proteobacteria,42XHB@68525|delta/epsilon subdivisions,2WSKY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
GDHHQS1_k127_13991400_0	177439.DP2458	6.626e-103	349.0	COG1482@1|root,COG1482@2|Bacteria,1MUD8@1224|Proteobacteria,42QR1@68525|delta/epsilon subdivisions,2WU24@28221|Deltaproteobacteria,2MMJP@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphomannose isomerase type I	-	-	5.3.1.8,5.4.2.8	ko:K01809,ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818,R01819	RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
GDHHQS1_k127_13991400_8	393921.HQ45_01840	7.101e-05	55.0	2CG1Y@1|root,31NHZ@2|Bacteria,4NQ9Z@976|Bacteroidetes,2FSBR@200643|Bacteroidia,22YJ9@171551|Porphyromonadaceae	976|Bacteroidetes	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
GDHHQS1_k127_13991400_4	1321815.HMPREF9193_01811	9.824e-39	152.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS1_k127_13991400_5	697281.Mahau_2282	2.522e-27	115.0	COG0407@1|root,COG0407@2|Bacteria,1UZSW@1239|Firmicutes,24E13@186801|Clostridia,42IBM@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_13991400_1	697281.Mahau_2282	1.07e-97	329.0	COG0407@1|root,COG0407@2|Bacteria,1UZSW@1239|Firmicutes,24E13@186801|Clostridia,42IBM@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_13991400_6	1382304.JNIL01000001_gene757	6.148e-26	114.0	COG2318@1|root,COG2318@2|Bacteria,1VWJD@1239|Firmicutes,4HWMJ@91061|Bacilli	91061|Bacilli	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
GDHHQS1_k127_13991400_3	926550.CLDAP_24220	2.145e-76	269.0	28JDC@1|root,2Z97R@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
GDHHQS1_k127_13999798_2	717605.Theco_2711	9.444e-33	131.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,4H9PE@91061|Bacilli,26TMT@186822|Paenibacillaceae	91061|Bacilli	E	Cystathionine beta-lyase	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS1_k127_13999798_0	1499967.BAYZ01000095_gene4075	1.325e-84	287.0	COG2220@1|root,COG2220@2|Bacteria,2NQD1@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
GDHHQS1_k127_13999798_1	665571.STHERM_c11920	4.998e-74	271.0	2F00C@1|root,33T4C@2|Bacteria,2J5MS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14118303_4	1047013.AQSP01000100_gene587	5.306e-50	196.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_14118303_3	744872.Spica_0155	1.221e-55	220.0	COG1839@1|root,COG1839@2|Bacteria,2JAAH@203691|Spirochaetes	203691|Spirochaetes	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
GDHHQS1_k127_14118303_1	665571.STHERM_c21760	5.549e-204	649.0	COG0072@1|root,COG0072@2|Bacteria,2J63Q@203691|Spirochaetes	203691|Spirochaetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5,tRNA-synt_2d,tRNA_bind
GDHHQS1_k127_14118303_0	573413.Spirs_4136	4.476e-217	685.0	COG0016@1|root,COG0016@2|Bacteria,2J63H@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
GDHHQS1_k127_14118303_2	251221.35212324	1.59e-117	401.0	COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf,Saccharop_dh_N
GDHHQS1_k127_14118303_6	1382359.JIAL01000001_gene2089	1.411e-16	94.0	COG1418@1|root,COG1418@2|Bacteria,3Y4NV@57723|Acidobacteria,2JJD3@204432|Acidobacteriia	204432|Acidobacteriia	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
GDHHQS1_k127_14118303_5	545694.TREPR_1573	2.172e-44	178.0	COG0477@1|root,COG2814@2|Bacteria,2J7NT@203691|Spirochaetes	203691|Spirochaetes	EGP	Major Facilitator	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
GDHHQS1_k127_14118303_7	180332.JTGN01000024_gene1707	1.219e-13	72.0	COG0407@1|root,COG0407@2|Bacteria	180332.JTGN01000024_gene1707|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14145490_0	744872.Spica_1344	4.324e-51	191.0	2C2MH@1|root,33D2Y@2|Bacteria,2J70Q@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14145490_1	1480694.DC28_00145	1.769e-48	181.0	COG0125@1|root,COG0125@2|Bacteria,2J765@203691|Spirochaetes	203691|Spirochaetes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
GDHHQS1_k127_14145490_2	1499967.BAYZ01000065_gene6092	6.683e-27	117.0	COG0811@1|root,COG0811@2|Bacteria,2NPUZ@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	exbB2	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
GDHHQS1_k127_14145490_3	1121413.JMKT01000014_gene2543	9.331e-08	63.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,42SKN@68525|delta/epsilon subdivisions,2WNIQ@28221|Deltaproteobacteria,2MBS5@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
GDHHQS1_k127_14202252_0	335543.Sfum_2180	6.45e-157	526.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,2MQH9@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
GDHHQS1_k127_14202252_1	1254432.SCE1572_04480	2.087e-38	151.0	COG1716@1|root,COG2203@1|root,COG3829@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YZGR@29|Myxococcales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
GDHHQS1_k127_14323869_9	55952.BU52_14345	1.206e-11	74.0	COG0584@1|root,COG0584@2|Bacteria,2GM3M@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ1	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
GDHHQS1_k127_14323869_0	658086.HMPREF0994_04300	1.784e-110	368.0	COG0407@1|root,COG0407@2|Bacteria,1VSHN@1239|Firmicutes,24FDR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_14323869_3	1247963.JPHU01000023_gene52	1.155e-52	196.0	28JTN@1|root,2Z9IV@2|Bacteria,1RCK3@1224|Proteobacteria,2URGH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14323869_5	96561.Dole_0232	2.335e-36	153.0	COG1846@1|root,COG1846@2|Bacteria,1RETW@1224|Proteobacteria,434CA@68525|delta/epsilon subdivisions,2WWMF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14323869_8	1123226.KB899284_gene3791	3.991e-18	94.0	COG0642@1|root,COG2205@2|Bacteria,1UHUJ@1239|Firmicutes,4ISDY@91061|Bacilli,26QMH@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	ciaH	-	2.7.13.3	ko:K14982	ko02020,ko02024,map02020,map02024	M00521	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
GDHHQS1_k127_14323869_1	697281.Mahau_0032	3.375e-79	283.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_14323869_10	700508.D174_07340	7.661e-06	59.0	COG0477@1|root,COG2814@2|Bacteria,2GMWE@201174|Actinobacteria,2351V@1762|Mycobacteriaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
GDHHQS1_k127_14323869_4	1122919.KB905560_gene1455	4.222e-41	173.0	COG3533@1|root,COG3533@2|Bacteria,1VU2F@1239|Firmicutes,4I3KW@91061|Bacilli,26VY6@186822|Paenibacillaceae	91061|Bacilli	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127
GDHHQS1_k127_14323869_2	452637.Oter_3739	4.944e-55	210.0	COG3148@1|root,COG3148@2|Bacteria,46VF1@74201|Verrucomicrobia,3K7WX@414999|Opitutae	414999|Opitutae	S	DTW	-	-	-	-	-	-	-	-	-	-	-	-	DTW
GDHHQS1_k127_14323869_11	1206741.BAFX01000195_gene3646	0.0003012	51.0	28TU2@1|root,2ZG15@2|Bacteria,2GV0E@201174|Actinobacteria,4G1E7@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14323869_6	158189.SpiBuddy_0679	2.09e-35	149.0	2EWYX@1|root,33QA8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14326485_1	665571.STHERM_c07710	8.963e-93	317.0	COG1345@1|root,COG1345@2|Bacteria,2J6CW@203691|Spirochaetes	203691|Spirochaetes	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
GDHHQS1_k127_14326485_8	573413.Spirs_2601	6.316e-14	85.0	2FFSV@1|root,347Q1@2|Bacteria,2J89P@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_14326485_3	1123274.KB899419_gene1887	3.756e-55	214.0	2C7TY@1|root,3483E@2|Bacteria,2J803@203691|Spirochaetes	203691|Spirochaetes	S	Type IV pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
GDHHQS1_k127_14326485_7	1123274.KB899419_gene1885	6.456e-30	132.0	COG0802@1|root,COG0802@2|Bacteria,2J8H4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
GDHHQS1_k127_14326485_5	573413.Spirs_2605	8.296e-32	138.0	COG1214@1|root,COG1214@2|Bacteria,2J80U@203691|Spirochaetes	203691|Spirochaetes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
GDHHQS1_k127_14326485_2	744872.Spica_1119	1.292e-79	282.0	COG2206@1|root,COG2206@2|Bacteria,2J588@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5
GDHHQS1_k127_14326485_4	545694.TREPR_1921	1.02e-46	172.0	COG1699@1|root,COG1699@2|Bacteria,2J7ZU@203691|Spirochaetes	203691|Spirochaetes	N	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
GDHHQS1_k127_14326485_0	889378.Spiaf_0795	1.127e-107	367.0	COG1344@1|root,COG1344@2|Bacteria,2J6BJ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein 3	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
GDHHQS1_k127_14326485_6	1307761.L21SP2_1228	1.552e-31	125.0	COG1256@1|root,COG1256@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
GDHHQS1_k127_1481765_2	573413.Spirs_1501	7.7e-29	120.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS1_k127_1481765_1	1128398.Curi_c21360	4.085e-51	196.0	COG0685@1|root,COG0685@2|Bacteria,1USZE@1239|Firmicutes,250HQ@186801|Clostridia	186801|Clostridia	C	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
GDHHQS1_k127_1481765_0	525897.Dbac_2687	1.591e-162	519.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2MA8W@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
GDHHQS1_k127_1574907_3	1307761.L21SP2_1459	1.372e-09	65.0	COG0760@1|root,COG0760@2|Bacteria,2J720@203691|Spirochaetes	203691|Spirochaetes	O	PFAM PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,SurA_N_2,SurA_N_3
GDHHQS1_k127_1574907_1	573413.Spirs_2349	2.772e-63	242.0	2F58Y@1|root,33W1Y@2|Bacteria,2JBFR@203691|Spirochaetes	203691|Spirochaetes	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1577,PilZ
GDHHQS1_k127_1574907_0	889378.Spiaf_2017	6.959e-113	381.0	COG1078@1|root,COG1078@2|Bacteria,2J64T@203691|Spirochaetes	203691|Spirochaetes	S	HD superfamily phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
GDHHQS1_k127_1574907_2	665571.STHERM_c06710	8.354e-10	70.0	COG0037@1|root,COG0037@2|Bacteria,2J61I@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the TtcA family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
GDHHQS1_k127_1588610_0	545694.TREPR_2328	2.085e-82	283.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
GDHHQS1_k127_1588610_2	1125701.HMPREF1221_00411	1.098e-16	91.0	COG2891@1|root,COG2891@2|Bacteria,2J89Q@203691|Spirochaetes	203691|Spirochaetes	M	Rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
GDHHQS1_k127_1588610_1	744872.Spica_1388	1.042e-58	214.0	COG1792@1|root,COG1792@2|Bacteria,2J77U@203691|Spirochaetes	203691|Spirochaetes	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
GDHHQS1_k127_16245_1	555079.Toce_0687	6.622e-59	212.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,42FAD@68295|Thermoanaerobacterales	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
GDHHQS1_k127_16245_0	1307761.L21SP2_3472	2.02e-204	661.0	COG1252@1|root,COG1252@2|Bacteria,2J79T@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
GDHHQS1_k127_16245_2	744872.Spica_2584	7.12e-40	161.0	COG0142@1|root,COG0142@2|Bacteria,2J7G9@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
GDHHQS1_k127_1641187_3	1194165.CAJF01000005_gene2311	2.162e-96	339.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
GDHHQS1_k127_1641187_5	452637.Oter_3660	4.62e-75	269.0	COG0793@1|root,COG0793@2|Bacteria,46Z7X@74201|Verrucomicrobia	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41
GDHHQS1_k127_1641187_0	1125725.HMPREF1325_2667	4.169e-159	516.0	COG4806@1|root,COG4806@2|Bacteria,2J6VW@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the rhamnose isomerase family	rhaA	-	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
GDHHQS1_k127_1641187_4	755731.Clo1100_2348	1.072e-76	272.0	arCOG12964@1|root,2Z7HP@2|Bacteria,1UZIT@1239|Firmicutes,24G0N@186801|Clostridia,36GIJ@31979|Clostridiaceae	186801|Clostridia	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
GDHHQS1_k127_1641187_2	1195236.CTER_3527	2.166e-116	385.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,3WIUA@541000|Ruminococcaceae	186801|Clostridia	S	aldo keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
GDHHQS1_k127_1641187_6	1123248.KB893320_gene3890	8.15e-32	135.0	COG3595@1|root,COG3595@2|Bacteria,4NSAQ@976|Bacteroidetes,1ITBV@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
GDHHQS1_k127_1641187_1	1304880.JAGB01000002_gene1897	4.333e-139	456.0	COG3387@1|root,COG3387@2|Bacteria,1VSEY@1239|Firmicutes	1239|Firmicutes	G	Alpha-L-rhamnosidase N-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,FIVAR
GDHHQS1_k127_1653111_2	1499967.BAYZ01000088_gene5106	6.747e-47	175.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
GDHHQS1_k127_1653111_0	344747.PM8797T_10544	2.39e-124	429.0	COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes	203682|Planctomycetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
GDHHQS1_k127_1653111_1	665571.STHERM_c19210	6.905e-89	320.0	COG4412@1|root,COG4412@2|Bacteria,2JAS0@203691|Spirochaetes	203691|Spirochaetes	S	Peptidase M30	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M30
GDHHQS1_k127_1668345_2	1297581.H919_10493	2.226e-18	95.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HH84@91061|Bacilli,21WTM@150247|Anoxybacillus	91061|Bacilli	M	NlpC/P60 family	lytE	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3,SLH
GDHHQS1_k127_1668345_0	1480694.DC28_01980	6.335e-107	364.0	COG0728@1|root,COG0728@2|Bacteria,2J697@203691|Spirochaetes	203691|Spirochaetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
GDHHQS1_k127_1668345_1	889378.Spiaf_1529	3.792e-30	139.0	COG1413@1|root,COG1413@2|Bacteria,2J5WK@203691|Spirochaetes	203691|Spirochaetes	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
GDHHQS1_k127_1751569_8	1051632.TPY_1166	2.262e-55	197.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia	186801|Clostridia	E	PFAM DAHP synthetase I	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
GDHHQS1_k127_1751569_7	665571.STHERM_c00260	1.964e-60	218.0	COG5497@1|root,COG5497@2|Bacteria,2J7E8@203691|Spirochaetes	203691|Spirochaetes	S	Predicted secreted protein (DUF2259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2259
GDHHQS1_k127_1751569_1	573413.Spirs_0261	9.013e-218	685.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
GDHHQS1_k127_1751569_11	906968.Trebr_0826	2.413e-08	68.0	2BTSM@1|root,32P03@2|Bacteria,2J74P@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1751569_5	665956.HMPREF1032_00837	7.286e-79	282.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_1751569_3	1156844.KB891842_gene7354	1.057e-160	518.0	COG3579@1|root,COG3579@2|Bacteria,2GNYU@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase C1-like family	pepC2	-	3.4.22.40	ko:K01372	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C1_2
GDHHQS1_k127_1751569_2	1304880.JAGB01000002_gene1654	9.843e-174	554.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
GDHHQS1_k127_1751569_9	716544.wcw_0275	2.125e-31	132.0	COG2120@1|root,COG2120@2|Bacteria,2JG3Z@204428|Chlamydiae	204428|Chlamydiae	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
GDHHQS1_k127_1751569_10	1188256.BASI01000001_gene809	1.27e-23	116.0	COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria,3FDVB@34008|Rhodovulum	28211|Alphaproteobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,Response_reg,SpoIIE
GDHHQS1_k127_1751569_0	1307761.L21SP2_0016	2.315e-303	962.0	COG0046@1|root,COG0046@2|Bacteria,2J66J@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
GDHHQS1_k127_1751569_6	1480694.DC28_09095	2.657e-75	261.0	COG0047@1|root,COG0047@2|Bacteria,2J8JD@203691|Spirochaetes	203691|Spirochaetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	-	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
GDHHQS1_k127_1751569_4	255470.cbdbA1608	1.014e-125	428.0	COG4191@1|root,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,34DMY@301297|Dehalococcoidia	301297|Dehalococcoidia	T	N-terminal 7TM region of histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,HisKA_7TM,PAS_9,Response_reg
GDHHQS1_k127_1772328_3	545695.TREAZ_1098	5.911e-25	105.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
GDHHQS1_k127_1772328_0	1267535.KB906767_gene433	3.777e-163	537.0	COG0480@1|root,COG0480@2|Bacteria,3Y2RR@57723|Acidobacteria,2JI85@204432|Acidobacteriia	204432|Acidobacteriia	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
GDHHQS1_k127_1772328_4	754027.HMPREF9554_00382	1.474e-05	53.0	2FC9X@1|root,2ZJPR@2|Bacteria,2J8DF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1772328_2	1089553.Tph_c18570	2.805e-64	244.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42EWB@68295|Thermoanaerobacterales	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
GDHHQS1_k127_1772328_1	573413.Spirs_2624	2.792e-72	259.0	2CK99@1|root,3464J@2|Bacteria,2J60S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1777363_0	589865.DaAHT2_0063	1.206e-164	526.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
GDHHQS1_k127_1890020_4	158190.SpiGrapes_3123	3.044e-80	273.0	COG2080@1|root,COG2080@2|Bacteria,2JAIS@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
GDHHQS1_k127_1890020_0	158190.SpiGrapes_3122	0.0	1280.0	COG1529@1|root,COG1529@2|Bacteria,2J9MJ@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS1_k127_1890020_1	158190.SpiGrapes_3121	0.0	1013.0	COG0493@1|root,COG1319@1|root,COG0493@2|Bacteria,COG1319@2|Bacteria,2J5W1@203691|Spirochaetes	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
GDHHQS1_k127_1890020_5	324602.Caur_0190	1.647e-26	120.0	COG1196@1|root,COG1196@2|Bacteria,2G788@200795|Chloroflexi,376Y7@32061|Chloroflexia	32061|Chloroflexia	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
GDHHQS1_k127_1890020_2	1111479.AXAR01000001_gene166	9.734e-120	396.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,4HBKY@91061|Bacilli,279KA@186823|Alicyclobacillaceae	91061|Bacilli	L	THUMP	ypsC	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
GDHHQS1_k127_1890020_6	426355.Mrad2831_0324	9.605e-11	72.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria,1JUJZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM Cyclic nucleotide-binding	MA20_39330	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
GDHHQS1_k127_1890020_7	1069080.KB913028_gene736	1.098e-06	61.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,4H2GJ@909932|Negativicutes	909932|Negativicutes	N	flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
GDHHQS1_k127_1890020_3	941824.TCEL_01715	1.457e-80	278.0	COG0144@1|root,COG0144@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,36F0B@31979|Clostridiaceae	186801|Clostridia	J	NOL1 NOP2 sun family	rsmF	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
GDHHQS1_k127_1890020_8	744872.Spica_2768	4.43e-06	59.0	COG0744@1|root,COG0744@2|Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365,ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
GDHHQS1_k127_1893105_0	926569.ANT_27190	1.4e-205	656.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	mdlB	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_1893105_1	1121104.AQXH01000001_gene1465	3.185e-52	187.0	COG1164@1|root,COG1164@2|Bacteria,4NFYH@976|Bacteroidetes	976|Bacteroidetes	E	TIGRFAM oligoendopeptidase, M3 family	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
GDHHQS1_k127_1912395_0	879212.DespoDRAFT_02243	1.694e-59	219.0	COG0820@1|root,COG0820@2|Bacteria,1R67K@1224|Proteobacteria,42PCI@68525|delta/epsilon subdivisions,2WJI5@28221|Deltaproteobacteria,2MIKV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
GDHHQS1_k127_1918471_1	1382359.JIAL01000001_gene1875	2.422e-42	161.0	COG0195@1|root,COG0195@2|Bacteria,3Y379@57723|Acidobacteria,2JIAX@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
GDHHQS1_k127_1918471_2	1231241.Mc24_02723	6.795e-31	128.0	COG0779@1|root,COG0779@2|Bacteria,2GD89@200918|Thermotogae	200918|Thermotogae	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
GDHHQS1_k127_1918471_0	626939.HMPREF9443_00484	1.018e-67	239.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,4H28W@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
GDHHQS1_k127_1952159_3	1123372.AUIT01000012_gene1693	8.948e-07	51.0	COG3103@1|root,COG4991@2|Bacteria,2GHRI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1952159_1	573413.Spirs_3350	4.629e-15	87.0	28X9U@1|root,2ZJ7V@2|Bacteria,2J87S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1952159_0	1458275.AZ34_08275	1.019e-49	201.0	COG3386@1|root,COG3391@1|root,COG4783@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,COG4783@2|Bacteria,1R1XY@1224|Proteobacteria,2VX19@28216|Betaproteobacteria,4AJMH@80864|Comamonadaceae	28216|Betaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_2,TPR_8
GDHHQS1_k127_1952159_2	56107.Cylst_0426	1.179e-12	81.0	COG0823@1|root,COG5276@1|root,COG0823@2|Bacteria,COG5276@2|Bacteria,1GQ7S@1117|Cyanobacteria,1HRXM@1161|Nostocales	1117|Cyanobacteria	Q	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347,HemolysinCabind,LVIVD
GDHHQS1_k127_1963981_16	1137269.AZWL01000003_gene1422	2.182e-13	73.0	COG1070@1|root,COG1070@2|Bacteria,2GISK@201174|Actinobacteria	201174|Actinobacteria	G	Carbohydrate kinase	rhaB	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_1963981_12	530564.Psta_3726	3.202e-29	124.0	COG0637@1|root,COG0637@2|Bacteria,2IZIM@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
GDHHQS1_k127_1963981_1	42256.RradSPS_2475	3.655e-169	559.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GKFE@201174|Actinobacteria,4CRQ6@84995|Rubrobacteria	84995|Rubrobacteria	C	COG COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit Energy production and conversion	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_1963981_7	525904.Tter_2003	9.419e-51	198.0	COG1878@1|root,COG1878@2|Bacteria,2NRE5@2323|unclassified Bacteria	2|Bacteria	S	Putative cyclase	-	-	1.1.1.363,1.1.1.49,3.5.1.9	ko:K00036,ko:K07130	ko00030,ko00380,ko00480,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00380,map00480,map00630,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008,M00038	R00835,R00988,R01959,R02736,R04911,R10907	RC00001,RC00066,RC00263,RC00323	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cyclase
GDHHQS1_k127_1963981_10	1094508.Tsac_2298	1.178e-42	168.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,24BR4@186801|Clostridia,42G9P@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator (RpiR family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
GDHHQS1_k127_1963981_3	382464.ABSI01000011_gene3127	9.273e-92	317.0	COG0673@1|root,COG0673@2|Bacteria,46UE2@74201|Verrucomicrobia,2IVCT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_1963981_6	661478.OP10G_2749	3.071e-52	207.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_1963981_17	886293.Sinac_0912	1.342e-07	66.0	COG5276@1|root,COG5276@2|Bacteria,2IXW8@203682|Planctomycetes	203682|Planctomycetes	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
GDHHQS1_k127_1963981_18	1907.SGLAU_00645	0.0008884	53.0	COG4733@1|root,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14
GDHHQS1_k127_1963981_11	1297742.A176_00262	1.517e-30	141.0	COG1470@1|root,COG2885@1|root,COG4719@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
GDHHQS1_k127_1963981_9	545694.TREPR_2780	7.104e-47	192.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1963981_4	445335.CBN_1409	5.522e-78	269.0	COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,36H4D@31979|Clostridiaceae	186801|Clostridia	G	Class II aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
GDHHQS1_k127_1963981_0	1211813.CAPH01000003_gene1376	1.003e-190	616.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,4NEM0@976|Bacteroidetes,2FWDE@200643|Bacteroidia	976|Bacteroidetes	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short,adh_short_C2
GDHHQS1_k127_1963981_5	338966.Ppro_0727	5.068e-56	202.0	COG0655@1|root,COG0655@2|Bacteria,1N3NQ@1224|Proteobacteria,42TRR@68525|delta/epsilon subdivisions,2WQ13@28221|Deltaproteobacteria,43VWV@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
GDHHQS1_k127_1963981_2	301.JNHE01000001_gene383	6.97e-134	453.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1YI2S@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
GDHHQS1_k127_1963981_15	1396.DJ87_2853	1.687e-17	96.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,4HB1C@91061|Bacilli,1ZASA@1386|Bacillus	91061|Bacilli	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	yisV	-	-	ko:K18907	-	M00700,M00702	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	Aminotran_1_2,GntR
GDHHQS1_k127_1963981_8	658086.HMPREF0994_05295	1.531e-49	192.0	COG5012@1|root,COG5012@2|Bacteria,1UF8A@1239|Firmicutes,24CAU@186801|Clostridia	186801|Clostridia	S	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_1963981_13	502025.Hoch_0149	3.111e-22	102.0	COG1186@1|root,COG1186@2|Bacteria,1ND5C@1224|Proteobacteria,430VS@68525|delta/epsilon subdivisions,2WW3U@28221|Deltaproteobacteria,2Z2GT@29|Myxococcales	28221|Deltaproteobacteria	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
GDHHQS1_k127_1963981_14	744872.Spica_0734	3.853e-21	94.0	COG0642@1|root,COG2205@2|Bacteria,2J63U@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS1_k127_1970956_4	926550.CLDAP_07740	5.178e-44	178.0	COG3250@1|root,COG3250@2|Bacteria,2G61D@200795|Chloroflexi	200795|Chloroflexi	G	glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
GDHHQS1_k127_1970956_0	526222.Desal_1841	4.56e-76	271.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MA7Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
GDHHQS1_k127_1970956_5	1179773.BN6_00630	3.949e-21	97.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4E2DS@85010|Pseudonocardiales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS1_k127_1970956_2	1121451.DESAM_22101	3.465e-54	219.0	COG2202@1|root,COG2984@1|root,COG3852@1|root,COG2202@2|Bacteria,COG2984@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria,42NXV@68525|delta/epsilon subdivisions,2X6Z9@28221|Deltaproteobacteria,2MH91@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3
GDHHQS1_k127_1970956_1	926550.CLDAP_21010	1.932e-61	243.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G6ZM@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
GDHHQS1_k127_1970956_3	278957.ABEA03000084_gene2325	1.205e-49	183.0	COG3822@1|root,COG3822@2|Bacteria	2|Bacteria	S	D-lyxose isomerase	-	-	5.3.1.15	ko:K09988	ko00040,map00040	-	R01898	RC00516	ko00000,ko00001,ko01000	-	-	-	Lyx_isomer
GDHHQS1_k127_1987881_1	1307761.L21SP2_0921	1.145e-126	418.0	COG5000@1|root,COG5000@2|Bacteria,2J5RG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
GDHHQS1_k127_1987881_0	1480694.DC28_14140	4.019e-187	614.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_1991267_4	909663.KI867150_gene2881	2.349e-47	177.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
GDHHQS1_k127_1991267_9	909663.KI867150_gene2880	3.75e-17	90.0	COG0745@1|root,COG0745@2|Bacteria,1PGXZ@1224|Proteobacteria,437JJ@68525|delta/epsilon subdivisions,2X2TK@28221|Deltaproteobacteria,2MSE0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
GDHHQS1_k127_1991267_7	880073.Calab_0422	4.614e-22	101.0	COG0745@1|root,COG0745@2|Bacteria,2NRCE@2323|unclassified Bacteria	2|Bacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
GDHHQS1_k127_1991267_2	1191523.MROS_2483	5.817e-164	540.0	COG2221@1|root,COG4191@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4191@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,HATPase_c,HTH_8,HisKA,PAS_8,Sigma54_activat
GDHHQS1_k127_1991267_1	573413.Spirs_0474	1.645e-258	808.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6JA@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	1.12.1.3,1.17.99.7,1.6.5.3	ko:K00336,ko:K18332,ko:K22015	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
GDHHQS1_k127_1991267_0	573413.Spirs_0475	0.0	1245.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2J5W1@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
GDHHQS1_k127_1991267_8	903814.ELI_0845	3.508e-20	99.0	COG3411@1|root,COG3411@2|Bacteria,1V6DT@1239|Firmicutes,24M31@186801|Clostridia,25X30@186806|Eubacteriaceae	186801|Clostridia	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx
GDHHQS1_k127_1991267_3	573413.Spirs_0476	2.292e-56	204.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
GDHHQS1_k127_1991267_6	935948.KE386494_gene220	3.202e-27	119.0	COG4191@1|root,COG4191@2|Bacteria,1V6MN@1239|Firmicutes,24JDQ@186801|Clostridia,42GGE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
GDHHQS1_k127_1991267_5	706587.Desti_2749	2.404e-31	131.0	COG0613@1|root,COG0613@2|Bacteria,1N68X@1224|Proteobacteria,42TYN@68525|delta/epsilon subdivisions,2WR34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PHP-associated	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP_C
GDHHQS1_k127_1996402_0	596324.TREVI0001_0588	7.565e-174	589.0	COG0841@1|root,COG0841@2|Bacteria,2JBCY@203691|Spirochaetes	203691|Spirochaetes	V	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
GDHHQS1_k127_1996402_1	545694.TREPR_2079	1.34e-14	76.0	COG2911@1|root,COG2911@2|Bacteria,2JBJG@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
GDHHQS1_k127_2001206_13	344747.PM8797T_05260	1.258e-13	79.0	COG0344@1|root,COG0344@2|Bacteria,2J0DJ@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	DUF4149,G3P_acyltransf
GDHHQS1_k127_2001206_8	1245469.S58_53260	1.367e-48	188.0	COG1349@1|root,COG1349@2|Bacteria,1QM4U@1224|Proteobacteria,2TU6A@28211|Alphaproteobacteria,3JTZE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GK	DeoR C terminal sensor domain	ulaR	-	-	ko:K03477	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
GDHHQS1_k127_2001206_7	697281.Mahau_1767	4.732e-52	205.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,42EWH@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783,ko:K17195	ko00030,ko00040,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529,R09031	RC00540,RC03111	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
GDHHQS1_k127_2001206_1	1303518.CCALI_02349	5.199e-121	398.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_2001206_3	1197706.AKKK01000039_gene3931	3.556e-91	311.0	COG1063@1|root,COG1063@2|Bacteria,2IDWX@201174|Actinobacteria	201174|Actinobacteria	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.14,1.1.1.251	ko:K00008,ko:K00094	ko00040,ko00051,ko00052,ko01100,map00040,map00051,map00052,map01100	M00014	R00875,R01896,R05571	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_2001206_6	1499967.BAYZ01000050_gene2837	6.558e-82	296.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	iolE	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_2001206_2	926569.ANT_02320	3.058e-99	339.0	COG1735@1|root,COG1735@2|Bacteria,2G84H@200795|Chloroflexi	200795|Chloroflexi	C	Phosphotriesterase family	-	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
GDHHQS1_k127_2001206_11	221027.JO40_10010	1.155e-21	108.0	COG1011@1|root,COG1011@2|Bacteria,2J9H4@203691|Spirochaetes	203691|Spirochaetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
GDHHQS1_k127_2001206_5	177437.HRM2_43480	2.748e-83	302.0	COG0407@1|root,COG0407@2|Bacteria,1P737@1224|Proteobacteria,4328N@68525|delta/epsilon subdivisions,2WYF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2001206_0	545694.TREPR_3200	1.501e-153	498.0	COG1066@1|root,COG1066@2|Bacteria,2J5WN@203691|Spirochaetes	203691|Spirochaetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
GDHHQS1_k127_2001206_9	889378.Spiaf_0099	2.447e-42	177.0	COG1538@1|root,COG1538@2|Bacteria,2J914@203691|Spirochaetes	203691|Spirochaetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
GDHHQS1_k127_2001206_4	1480694.DC28_09150	3.405e-84	286.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
GDHHQS1_k127_2066139_8	768704.Desmer_3128	3.058e-96	330.0	COG0146@1|root,COG0146@2|Bacteria,1U1N7@1239|Firmicutes,24D6C@186801|Clostridia,2601B@186807|Peptococcaceae	186801|Clostridia	EQ	N-methylhydantoinase B acetone carboxylase, alpha subunit	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
GDHHQS1_k127_2066139_2	1122132.AQYH01000006_gene3688	3.973e-203	654.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,4B7WC@82115|Rhizobiaceae	28211|Alphaproteobacteria	EQ	N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
GDHHQS1_k127_2066139_16	1410653.JHVC01000001_gene1684	2.534e-31	139.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,36F6A@31979|Clostridiaceae	186801|Clostridia	K	GntR domain protein	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
GDHHQS1_k127_2066139_9	529709.PYCH_01760	7.367e-66	232.0	COG1042@1|root,arCOG01338@2157|Archaea,2XXCA@28890|Euryarchaeota,2435P@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
GDHHQS1_k127_2066139_13	391623.TERMP_01314	2.691e-35	156.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242YZ@183968|Thermococci	183968|Thermococci	C	Indolepyruvate ferredoxin oxidoreductase subunit	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
GDHHQS1_k127_2066139_5	1121430.JMLG01000001_gene2400	3.755e-131	445.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,24AKB@186801|Clostridia,260D3@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
GDHHQS1_k127_2066139_4	589924.Ferp_1490	1.786e-141	467.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246RE@183980|Archaeoglobi	183980|Archaeoglobi	C	acetyl coenzyme A synthetase	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
GDHHQS1_k127_2066139_6	573413.Spirs_1022	6.278e-119	390.0	COG0549@1|root,COG0549@2|Bacteria,2J64E@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
GDHHQS1_k127_2066139_10	1347392.CCEZ01000043_gene109	1.188e-59	222.0	COG0167@1|root,COG2768@1|root,COG0167@2|Bacteria,COG2768@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,36EA4@31979|Clostridiaceae	186801|Clostridia	C	dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4
GDHHQS1_k127_2066139_21	469616.FMAG_01038	6.495e-05	53.0	COG0402@1|root,COG0402@2|Bacteria,37908@32066|Fusobacteria	32066|Fusobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS1_k127_2066139_12	585506.HMPREF0877_0678	2.498e-38	161.0	COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,4HCX6@91061|Bacilli,4AYWS@81850|Leuconostocaceae	91061|Bacilli	F	Permease family	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
GDHHQS1_k127_2066139_20	1094980.Mpsy_0774	1.041e-07	59.0	COG1149@1|root,arCOG04073@2157|Archaea,2XWI1@28890|Euryarchaeota,2N9GG@224756|Methanomicrobia	224756|Methanomicrobia	D	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
GDHHQS1_k127_2066139_15	1123511.KB905843_gene934	2.762e-32	140.0	COG0167@1|root,COG2768@1|root,COG0167@2|Bacteria,COG2768@2|Bacteria,1TRPI@1239|Firmicutes,4H3Y6@909932|Negativicutes	1239|Firmicutes	F	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4
GDHHQS1_k127_2066139_11	1137269.AZWL01000031_gene3817	5.079e-45	174.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
GDHHQS1_k127_2066139_19	1223410.KN050846_gene888	2.083e-20	96.0	COG1695@1|root,COG1695@2|Bacteria,4NSI4@976|Bacteroidetes,1I2SA@117743|Flavobacteriia	976|Bacteroidetes	K	transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
GDHHQS1_k127_2066139_3	661478.OP10G_3758	1.509e-185	593.0	COG3534@1|root,COG3534@2|Bacteria	2|Bacteria	G	alpha-L-arabinofuranosidase	abfA	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
GDHHQS1_k127_2066139_18	383372.Rcas_4166	1.156e-20	104.0	COG1896@1|root,COG1896@2|Bacteria,2G72G@200795|Chloroflexi,3778D@32061|Chloroflexia	32061|Chloroflexia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
GDHHQS1_k127_2066139_1	743719.PaelaDRAFT_4236	2.251e-221	709.0	COG3387@1|root,COG3387@2|Bacteria,1VQTD@1239|Firmicutes,4HUGY@91061|Bacilli,26UXQ@186822|Paenibacillaceae	91061|Bacilli	G	Domain of unknown function (DUF5127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1793,DUF4964,DUF4965,DUF5127
GDHHQS1_k127_2066139_7	1122222.AXWR01000002_gene2178	1.214e-115	390.0	COG0477@1|root,COG2814@2|Bacteria,1WJGK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_2066139_14	1125863.JAFN01000001_gene957	1.567e-33	139.0	COG2445@1|root,COG2445@2|Bacteria,1NX6S@1224|Proteobacteria,430RY@68525|delta/epsilon subdivisions,2WVSE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
GDHHQS1_k127_2066139_17	555779.Dthio_PD0769	8.558e-27	118.0	29MUB@1|root,32NQ5@2|Bacteria,1P1HV@1224|Proteobacteria,43108@68525|delta/epsilon subdivisions,2WWMY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2066139_0	1232410.KI421415_gene2933	0.0	1363.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
GDHHQS1_k127_2097189_3	40571.JOEA01000012_gene1029	8.685e-18	85.0	COG1953@1|root,COG1953@2|Bacteria,2GJXN@201174|Actinobacteria,4DZ1Q@85010|Pseudonocardiales	201174|Actinobacteria	FH	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
GDHHQS1_k127_2097189_1	1254432.SCE1572_42640	1.566e-36	145.0	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,42VYV@68525|delta/epsilon subdivisions,2WRGQ@28221|Deltaproteobacteria,2Z0X7@29|Myxococcales	28221|Deltaproteobacteria	K	MerR, DNA binding	-	-	-	ko:K19591	-	M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
GDHHQS1_k127_2097189_2	1205680.CAKO01000007_gene4267	5.892e-31	128.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,2JSZV@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the HesB IscA family	iscA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
GDHHQS1_k127_2097189_0	926569.ANT_17980	8.506e-86	289.0	COG0396@1|root,COG0396@2|Bacteria,2G5S6@200795|Chloroflexi	200795|Chloroflexi	O	PFAM ABC transporter related	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
GDHHQS1_k127_2183868_1	1499967.BAYZ01000047_gene2738	4.331e-90	307.0	COG0053@1|root,COG0053@2|Bacteria,2NPHA@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
GDHHQS1_k127_2183868_0	573413.Spirs_0100	2.436e-103	344.0	COG1435@1|root,COG1435@2|Bacteria,2J6SK@203691|Spirochaetes	203691|Spirochaetes	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
GDHHQS1_k127_2258307_9	76114.ebA688	1.547e-07	53.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria,2KX2N@206389|Rhodocyclales	206389|Rhodocyclales	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
GDHHQS1_k127_2258307_4	573413.Spirs_3194	2.61e-67	238.0	COG0566@1|root,COG0566@2|Bacteria,2J748@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
GDHHQS1_k127_2258307_7	665571.STHERM_c18670	2.311e-19	92.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2,TonB_C
GDHHQS1_k127_2258307_2	292459.STH1434	5.321e-104	346.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
GDHHQS1_k127_2258307_5	292459.STH1435	1.517e-66	240.0	COG3392@1|root,COG3392@2|Bacteria,1TRWE@1239|Firmicutes,248Q7@186801|Clostridia	186801|Clostridia	L	D12 class N6 adenine-specific DNA methyltransferase	fokIM	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
GDHHQS1_k127_2258307_3	1121430.JMLG01000004_gene938	8.315e-98	338.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,261BN@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
GDHHQS1_k127_2258307_8	1278073.MYSTI_06364	3.982e-15	88.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AKM@68525|delta/epsilon subdivisions,2X60K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS1_k127_2258307_1	906968.Trebr_1496	9.242e-133	433.0	COG0484@1|root,COG0484@2|Bacteria,2J614@203691|Spirochaetes	203691|Spirochaetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
GDHHQS1_k127_2258307_0	1379698.RBG1_1C00001G1489	2.337e-257	815.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
GDHHQS1_k127_2258307_6	889378.Spiaf_1961	4.027e-26	111.0	COG0576@1|root,COG0576@2|Bacteria,2J7UP@203691|Spirochaetes	203691|Spirochaetes	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
GDHHQS1_k127_2268301_2	545695.TREAZ_3479	1.586e-49	186.0	COG1496@1|root,COG1496@2|Bacteria,2J7NB@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
GDHHQS1_k127_2268301_4	246969.TAM4_1472	2.055e-16	91.0	COG0454@1|root,arCOG00845@2157|Archaea,2Y67B@28890|Euryarchaeota,2430F@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS1_k127_2268301_1	1173026.Glo7428_3316	5.321e-52	201.0	COG0432@1|root,COG0432@2|Bacteria,1G61Z@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
GDHHQS1_k127_2268301_0	1173026.Glo7428_1980	2.158e-148	482.0	COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
GDHHQS1_k127_2268301_3	477974.Daud_0415	2.172e-32	132.0	COG2402@1|root,COG2402@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
GDHHQS1_k127_2268301_5	477974.Daud_0414	0.0002547	45.0	2DSVR@1|root,33HKS@2|Bacteria	2|Bacteria	L	CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,RHH_3,RHH_4
GDHHQS1_k127_2309983_1	525897.Dbac_2127	1.971e-133	432.0	COG1148@1|root,COG1148@2|Bacteria,1PTJ7@1224|Proteobacteria,42NJN@68525|delta/epsilon subdivisions,2WJHG@28221|Deltaproteobacteria,2M7R4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
GDHHQS1_k127_2309983_5	1411123.JQNH01000001_gene1785	4.22e-66	246.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	MA20_16780	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
GDHHQS1_k127_2309983_0	1480694.DC28_07175	5.526e-144	471.0	COG0747@1|root,COG0747@2|Bacteria,2J86R@203691|Spirochaetes	203691|Spirochaetes	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS1_k127_2309983_3	640513.Entas_3657	6.656e-80	284.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1SKPD@1236|Gammaproteobacteria,3X21W@547|Enterobacter	1236|Gammaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823,ko:K12372	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_2309983_2	1155718.KB891853_gene3493	4.422e-93	331.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	dppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_2309983_4	1089553.Tph_c03530	6.71e-79	275.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FXH@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS1_k127_2371951_0	1267535.KB906767_gene5172	3.977e-207	653.0	COG4225@1|root,COG4225@2|Bacteria,3Y6Y6@57723|Acidobacteria	57723|Acidobacteria	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
GDHHQS1_k127_2371951_1	1230342.CTM_20481	3.069e-151	492.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
GDHHQS1_k127_2371951_5	351016.RAZWK3B_19051	1.612e-32	135.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2U79E@28211|Alphaproteobacteria,2P34U@2433|Roseobacter	28211|Alphaproteobacteria	G	COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2	slyD	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
GDHHQS1_k127_2371951_3	292459.STH2587	4.61e-90	318.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
GDHHQS1_k127_2371951_4	744872.Spica_2772	2.923e-39	156.0	COG0071@1|root,COG0071@2|Bacteria,2J7MQ@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
GDHHQS1_k127_2371951_2	1047013.AQSP01000100_gene587	1.92e-132	434.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_2371951_6	338966.Ppro_2837	2.628e-29	117.0	COG1839@1|root,COG1839@2|Bacteria,1RBCB@1224|Proteobacteria,42S44@68525|delta/epsilon subdivisions,2WMAS@28221|Deltaproteobacteria,43UGI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
GDHHQS1_k127_2375781_1	340.xcc-b100_1204	1.457e-47	179.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1X3DB@135614|Xanthomonadales	135614|Xanthomonadales	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
GDHHQS1_k127_2375781_0	658086.HMPREF0994_03543	9.411e-91	311.0	28MXM@1|root,2Z8AT@2|Bacteria,1V0XI@1239|Firmicutes,24DIS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2397191_1	439235.Dalk_4226	3.384e-108	364.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MHY2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
GDHHQS1_k127_2397191_3	572478.Vdis_0672	0.0001	54.0	COG1708@1|root,arCOG01202@2157|Archaea	2157|Archaea	S	PFAM DNA polymerase beta domain protein region	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
GDHHQS1_k127_2397191_2	370438.PTH_0437	1.098e-23	113.0	COG2250@1|root,COG2250@2|Bacteria,1V8D8@1239|Firmicutes,24KPT@186801|Clostridia,265CJ@186807|Peptococcaceae	186801|Clostridia	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
GDHHQS1_k127_2397191_0	1307761.L21SP2_1484	3.029e-139	452.0	COG3639@1|root,COG3639@2|Bacteria,2J6TW@203691|Spirochaetes	203691|Spirochaetes	U	ABC transporter (Permease)	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
GDHHQS1_k127_2416706_0	744872.Spica_0331	6.912e-265	826.0	COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes	203691|Spirochaetes	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	malP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
GDHHQS1_k127_2416706_1	1123274.KB899419_gene1941	1.239e-134	443.0	COG0786@1|root,COG0786@2|Bacteria,2J7YK@203691|Spirochaetes	203691|Spirochaetes	E	glutamate symporter	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
GDHHQS1_k127_2416706_2	1382356.JQMP01000004_gene103	1.484e-108	365.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,27XV0@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
GDHHQS1_k127_2437190_3	357808.RoseRS_2835	1.725e-15	85.0	COG4030@1|root,COG4030@2|Bacteria,2G67Q@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
GDHHQS1_k127_2437190_0	1195236.CTER_1187	3.271e-225	721.0	COG1882@1|root,COG1882@2|Bacteria,1VTIM@1239|Firmicutes,24EPG@186801|Clostridia,3WRT2@541000|Ruminococcaceae	186801|Clostridia	H	Pyruvate formate lyase-like	-	-	-	-	-	-	-	-	-	-	-	-	Gly_radical,PFL-like
GDHHQS1_k127_2437190_2	237368.SCABRO_03792	6.479e-47	175.0	2DSB3@1|root,33FC0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2437190_5	1281779.H009_07584	0.0005089	52.0	COG1835@1|root,COG1835@2|Bacteria,1N4D5@1224|Proteobacteria,2U1QI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	ko:K11941	-	-	-	-	ko00000,ko01000	-	-	-	Acyl_transf_3
GDHHQS1_k127_2437190_1	1380394.JADL01000007_gene4523	1.856e-47	189.0	COG1835@1|root,COG1835@2|Bacteria,1MYXY@1224|Proteobacteria,2TVER@28211|Alphaproteobacteria,2JX1V@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
GDHHQS1_k127_2437190_4	1121124.JNIX01000013_gene1513	2.413e-15	80.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2KF9Q@204458|Caulobacterales	204458|Caulobacterales	Q	PFAM Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS1_k127_245348_0	1267535.KB906767_gene5490	2.485e-160	514.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,Fucosidase_C
GDHHQS1_k127_245348_1	344747.PM8797T_30137	4.329e-67	252.0	COG4106@1|root,COG4106@2|Bacteria,2IZUZ@203682|Planctomycetes	203682|Planctomycetes	S	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
GDHHQS1_k127_245348_2	410358.Mlab_1184	2.492e-31	137.0	COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,2NAUF@224756|Methanomicrobia	224756|Methanomicrobia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
GDHHQS1_k127_245348_3	1170562.Cal6303_2855	9.169e-08	56.0	COG1609@1|root,COG1609@2|Bacteria,1G54D@1117|Cyanobacteria,1HMP3@1161|Nostocales	1117|Cyanobacteria	K	PFAM Rhodopirellula transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
GDHHQS1_k127_24991_1	697281.Mahau_2021	4.358e-54	211.0	COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,24INX@186801|Clostridia,42GXX@68295|Thermoanaerobacterales	186801|Clostridia	G	isomerase	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
GDHHQS1_k127_24991_0	742725.HMPREF9450_00812	1.63e-108	361.0	COG1940@1|root,COG1940@2|Bacteria,4NHG5@976|Bacteroidetes,2FQJC@200643|Bacteroidia	976|Bacteroidetes	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
GDHHQS1_k127_24991_2	665571.STHERM_c02830	1.018e-25	107.0	COG0174@1|root,COG0174@2|Bacteria,2J6JS@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
GDHHQS1_k127_2516795_2	573413.Spirs_1138	1.466e-34	150.0	COG1028@1|root,COG1028@2|Bacteria	573413.Spirs_1138|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2516795_0	401526.TcarDRAFT_1906	2.259e-214	675.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H23Y@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
GDHHQS1_k127_2516795_1	1242864.D187_008136	2.194e-119	400.0	COG0371@1|root,COG0371@2|Bacteria,1NAAM@1224|Proteobacteria	1224|Proteobacteria	C	Glycerol dehydrogenase and related enzymes	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
GDHHQS1_k127_2516795_3	631362.Thi970DRAFT_03790	0.0009897	48.0	COG3064@1|root,COG3064@2|Bacteria,1MZUF@1224|Proteobacteria,1S95Z@1236|Gammaproteobacteria,1WYT3@135613|Chromatiales	135613|Chromatiales	M	SprA-related family	-	-	-	-	-	-	-	-	-	-	-	-	SprA-related
GDHHQS1_k127_2525877_1	1267534.KB906756_gene626	6.089e-78	276.0	COG1028@1|root,COG1028@2|Bacteria,3Y67C@57723|Acidobacteria,2JM0Y@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
GDHHQS1_k127_2525877_0	1121405.dsmv_0287	5.474e-248	796.0	COG1042@1|root,COG1042@2|Bacteria,1NU6B@1224|Proteobacteria,42NAU@68525|delta/epsilon subdivisions,2WJHX@28221|Deltaproteobacteria,2MIMR@213118|Desulfobacterales	2|Bacteria	C	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
GDHHQS1_k127_2532912_0	1121920.AUAU01000009_gene1864	1.502e-20	108.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2532912_1	479434.Sthe_2440	1.478e-19	94.0	COG1505@1|root,COG1505@2|Bacteria,2GBNH@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
GDHHQS1_k127_2593553_1	439235.Dalk_1600	3.313e-93	325.0	COG0784@1|root,COG2202@1|root,COG3437@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_2593553_2	269799.Gmet_2789	8.53e-48	179.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,42T3B@68525|delta/epsilon subdivisions,2WP8H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
GDHHQS1_k127_2593553_0	338966.Ppro_2725	1.965e-150	506.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43BSB@68525|delta/epsilon subdivisions,2X735@28221|Deltaproteobacteria,43TD7@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SBP_bac_3
GDHHQS1_k127_259883_8	889378.Spiaf_1855	1.824e-30	124.0	COG0745@1|root,COG0745@2|Bacteria	889378.Spiaf_1855|-	T	phosphorelay signal transduction system	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	-
GDHHQS1_k127_259883_9	889378.Spiaf_1856	8.287e-27	118.0	COG1406@1|root,COG1406@2|Bacteria,2J88Z@203691|Spirochaetes	203691|Spirochaetes	N	Chemotaxis phosphatase CheX	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
GDHHQS1_k127_259883_6	1095767.CAHD01000104_gene998	2.157e-34	153.0	COG0643@1|root,COG0643@2|Bacteria,2IBKY@201174|Actinobacteria	201174|Actinobacteria	T	Signal transducing histidine kinase, homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
GDHHQS1_k127_259883_7	1121456.ATVA01000012_gene2670	1.06e-33	138.0	COG3794@1|root,COG3794@2|Bacteria,1N3IJ@1224|Proteobacteria,42TYB@68525|delta/epsilon subdivisions,2WR42@28221|Deltaproteobacteria,2MCVC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
GDHHQS1_k127_259883_11	136273.GY22_00755	8.455e-11	73.0	COG0604@1|root,COG0604@2|Bacteria,2I8SZ@201174|Actinobacteria,1W9Y4@1268|Micrococcaceae	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_259883_10	204669.Acid345_1798	2.577e-26	111.0	COG1695@1|root,COG1695@2|Bacteria,3Y4ST@57723|Acidobacteria,2JJFA@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
GDHHQS1_k127_259883_1	933262.AXAM01000038_gene896	1.644e-80	284.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42PTI@68525|delta/epsilon subdivisions,2WIWT@28221|Deltaproteobacteria,2MIKY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
GDHHQS1_k127_259883_4	880073.Calab_2711	1.21e-46	177.0	COG1443@1|root,COG1443@2|Bacteria,2NQ8N@2323|unclassified Bacteria	2|Bacteria	I	NUDIX domain	yfcD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.7.6.2,5.3.3.2	ko:K00949,ko:K01823	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R00619,R01123	RC00002,RC00017,RC00455	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0565	NUDIX
GDHHQS1_k127_259883_0	1121396.KB893013_gene3675	3.517e-116	384.0	COG0863@1|root,COG0863@2|Bacteria,1R7RV@1224|Proteobacteria,42NFT@68525|delta/epsilon subdivisions,2WJMQ@28221|Deltaproteobacteria,2MJ40@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
GDHHQS1_k127_259883_5	292459.STH181	1.836e-35	142.0	COG1595@1|root,COG1595@2|Bacteria,1VBIF@1239|Firmicutes,24P38@186801|Clostridia	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS1_k127_259883_2	665571.STHERM_c18100	1.597e-55	205.0	COG0300@1|root,COG0300@2|Bacteria,2J5I8@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
GDHHQS1_k127_259883_3	706587.Desti_1456	5.035e-49	182.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
GDHHQS1_k127_266989_6	247490.KSU1_D0866	3.829e-09	61.0	COG0745@1|root,COG0745@2|Bacteria	247490.KSU1_D0866|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_266989_4	889378.Spiaf_2305	4.543e-31	126.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K03413,ko:K21993	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035	1.A.16.2	-	-	Form_Nir_trans,HATPase_c,HTH_8,HisKA,Response_reg
GDHHQS1_k127_266989_3	525904.Tter_2505	2.432e-38	163.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Laminin_G_3,RicinB_lectin_2
GDHHQS1_k127_266989_0	1499967.BAYZ01000097_gene4327	2.519e-159	516.0	COG1486@1|root,COG1486@2|Bacteria	2|Bacteria	G	melibiose metabolic process	-	-	3.2.1.22,3.2.1.86	ko:K01222,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603	-	R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_266989_2	1499967.BAYZ01000009_gene5320	3.78e-72	251.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	M1-742	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
GDHHQS1_k127_266989_1	665571.STHERM_c18410	7.063e-76	263.0	COG3264@1|root,COG3264@2|Bacteria,2JBD8@203691|Spirochaetes	2|Bacteria	M	Mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
GDHHQS1_k127_266989_5	1480694.DC28_10705	2.095e-23	104.0	COG2430@1|root,COG2430@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF432
GDHHQS1_k127_2682832_2	889378.Spiaf_1518	3.439e-56	209.0	COG1386@1|root,COG1386@2|Bacteria,2J75V@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
GDHHQS1_k127_2682832_1	744872.Spica_1375	5.22e-86	300.0	COG1354@1|root,COG1354@2|Bacteria,2J5RF@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
GDHHQS1_k127_2682832_3	469381.Dpep_1457	1.338e-31	132.0	COG0801@1|root,COG1469@1|root,COG0801@2|Bacteria,COG1469@2|Bacteria,3TB8E@508458|Synergistetes	508458|Synergistetes	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	-	-	2.7.6.3,3.5.4.39	ko:K00950,ko:K17488	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R10348	RC00002,RC00017,RC02504,RC03131	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1,HPPK
GDHHQS1_k127_2682832_0	889378.Spiaf_1521	3.419e-116	379.0	COG0468@1|root,COG0468@2|Bacteria,2J5G5@203691|Spirochaetes	203691|Spirochaetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
GDHHQS1_k127_268451_1	1265505.ATUG01000001_gene3550	3.895e-07	63.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_9,Response_reg
GDHHQS1_k127_268451_0	324057.Pjdr2_2566	4.886e-188	599.0	COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,4IRIM@91061|Bacilli,26T43@186822|Paenibacillaceae	91061|Bacilli	O	Crystallin	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
GDHHQS1_k127_2755859_3	1321815.HMPREF9193_01929	1.965e-25	118.0	COG1652@1|root,COG1652@2|Bacteria,2J7QX@203691|Spirochaetes	203691|Spirochaetes	S	Treponemal membrane protein	tmpB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	LysM
GDHHQS1_k127_2755859_1	1116472.MGMO_224c00040	1.071e-104	350.0	COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,1RZ6E@1236|Gammaproteobacteria,1XFNN@135618|Methylococcales	135618|Methylococcales	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
GDHHQS1_k127_2755859_0	1041159.AZUW01000033_gene2486	1.637e-115	383.0	COG4030@1|root,COG4030@2|Bacteria,1NSDB@1224|Proteobacteria,2TSXU@28211|Alphaproteobacteria,4BD4W@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
GDHHQS1_k127_2755859_2	59374.Fisuc_1504	3.572e-75	264.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0004358,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.7.2.8	ko:K00619,ko:K00930,ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226	AA_kinase,Acetyltransf_1
GDHHQS1_k127_2821922_1	1307761.L21SP2_3112	2.21e-102	346.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF11,Gram_pos_anchor,Laminin_G_3
GDHHQS1_k127_2821922_3	180332.JTGN01000016_gene985	6.331e-61	235.0	28MXM@1|root,2ZB4M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2821922_5	1123371.ATXH01000001_gene1181	2.04e-45	179.0	COG1373@1|root,COG1373@2|Bacteria,2GGZJ@200940|Thermodesulfobacteria	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
GDHHQS1_k127_2821922_4	1536772.R70723_15160	2.455e-59	220.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26RMX@186822|Paenibacillaceae	91061|Bacilli	G	Glycoside hydrolase family 3	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4309,Glyco_hydro_3
GDHHQS1_k127_2821922_2	1304284.L21TH_1610	1.381e-74	264.0	COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,24A3M@186801|Clostridia,36G9F@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
GDHHQS1_k127_2821922_0	867845.KI911784_gene695	1.346e-102	340.0	COG4213@1|root,COG4213@2|Bacteria,2G6C4@200795|Chloroflexi,377C5@32061|Chloroflexia	32061|Chloroflexia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
GDHHQS1_k127_2856488_0	744872.Spica_0853	3.307e-187	597.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
GDHHQS1_k127_2898679_51	889378.Spiaf_0779	6.076e-09	65.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J6RF@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
GDHHQS1_k127_2898679_28	665571.STHERM_c07460	3.845e-75	269.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J6RF@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	nlpD	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
GDHHQS1_k127_2898679_11	1123274.KB899435_gene1312	1.93e-154	518.0	COG0768@1|root,COG0768@2|Bacteria,2J5D8@203691|Spirochaetes	203691|Spirochaetes	M	Cell division protein ftsI	pbp3	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
GDHHQS1_k127_2898679_27	545694.TREPR_2208	4.273e-80	289.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
GDHHQS1_k127_2898679_38	335541.Swol_0863	1.33e-37	156.0	COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,25E6A@186801|Clostridia,42JXC@68298|Syntrophomonadaceae	186801|Clostridia	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
GDHHQS1_k127_2898679_20	1121423.JONT01000006_gene2475	1.48e-95	344.0	COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,2603B@186807|Peptococcaceae	186801|Clostridia	NT	Signal transducing histidine kinase homodimeric	cheA3	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
GDHHQS1_k127_2898679_55	404589.Anae109_2293	1.289e-05	53.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
GDHHQS1_k127_2898679_54	573413.Spirs_1589	1.536e-06	62.0	28TF5@1|root,2ZFP6@2|Bacteria,2J8Y7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2898679_52	545694.TREPR_2843	4.236e-08	59.0	29A3I@1|root,31CTV@2|Bacteria,2J8T8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2898679_5	665571.STHERM_c09350	8.318e-189	609.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
GDHHQS1_k127_2898679_12	1480694.DC28_02445	1.44e-126	409.0	COG1191@1|root,COG1191@2|Bacteria,2J5RA@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS1_k127_2898679_14	665571.STHERM_c09320	3.204e-125	406.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
GDHHQS1_k127_2898679_16	744872.Spica_1524	5.97e-109	364.0	COG1419@1|root,COG1419@2|Bacteria,2J5TV@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
GDHHQS1_k127_2898679_1	665571.STHERM_c09300	3.225e-290	906.0	COG1298@1|root,COG1298@2|Bacteria,2J57F@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
GDHHQS1_k127_2898679_15	665571.STHERM_c09290	1.69e-117	403.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
GDHHQS1_k127_2898679_31	1123274.KB899413_gene837	1.936e-71	254.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
GDHHQS1_k127_2898679_42	744872.Spica_1528	1.369e-27	114.0	COG1987@1|root,COG1987@2|Bacteria,2J93G@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
GDHHQS1_k127_2898679_17	1123274.KB899413_gene839	2.812e-97	324.0	COG1338@1|root,COG1338@2|Bacteria,2J5S9@203691|Spirochaetes	203691|Spirochaetes	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
GDHHQS1_k127_2898679_43	1307761.L21SP2_1194	2.375e-25	114.0	COG3190@1|root,COG3190@2|Bacteria,2J8HN@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein, FliO	-	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
GDHHQS1_k127_2898679_19	573413.Spirs_1576	6.762e-96	328.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2J5P8@203691|Spirochaetes	203691|Spirochaetes	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
GDHHQS1_k127_2898679_8	573413.Spirs_1575	1.587e-170	540.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
GDHHQS1_k127_2898679_46	1125699.HMPREF9194_00948	3.166e-23	106.0	COG1580@1|root,COG1580@2|Bacteria,2J7MX@203691|Spirochaetes	203691|Spirochaetes	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
GDHHQS1_k127_2898679_18	573413.Spirs_1573	4.098e-97	322.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
GDHHQS1_k127_2898679_24	665571.STHERM_c09200	2.637e-89	305.0	COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes	203691|Spirochaetes	N	MotA TolQ ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
GDHHQS1_k127_2898679_40	889378.Spiaf_2096	2.861e-29	117.0	COG1582@1|root,COG1582@2|Bacteria,2J8UC@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar protein FlbD	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
GDHHQS1_k127_2898679_2	665571.STHERM_c09180	1.12e-214	675.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
GDHHQS1_k127_2898679_37	545694.TREPR_2864	2.983e-45	168.0	COG1843@1|root,COG1843@2|Bacteria,2J806@203691|Spirochaetes	203691|Spirochaetes	N	flagellar hook	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
GDHHQS1_k127_2898679_48	1123274.KB899413_gene849	3.751e-16	91.0	COG3144@1|root,COG3144@2|Bacteria,2J8AU@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-length control protein	-	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
GDHHQS1_k127_2898679_35	744872.Spica_1540	2.075e-48	181.0	COG3334@1|root,COG3334@2|Bacteria,2J66F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM MgtE intracellular	flbB	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	-
GDHHQS1_k127_2898679_50	545694.TREPR_2554	8.541e-14	77.0	COG2882@1|root,COG2882@2|Bacteria,2J8SK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar export protein FliJ	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
GDHHQS1_k127_2898679_4	744872.Spica_1667	1.432e-189	604.0	COG1157@1|root,COG1157@2|Bacteria,2J5IJ@203691|Spirochaetes	203691|Spirochaetes	NU	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
GDHHQS1_k127_2898679_23	744872.Spica_1668	7.774e-92	310.0	COG1317@1|root,COG1317@2|Bacteria,2J5KZ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
GDHHQS1_k127_2898679_7	1480694.DC28_02330	6.385e-180	569.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
GDHHQS1_k127_2898679_3	744872.Spica_1670	3.4e-195	624.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
GDHHQS1_k127_2898679_45	1123274.KB899413_gene856	1.819e-24	106.0	COG1677@1|root,COG1677@2|Bacteria,2J8B3@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-basal body complex protein	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
GDHHQS1_k127_2898679_29	665571.STHERM_c09080	1.471e-74	252.0	COG1558@1|root,COG1558@2|Bacteria,2J7Q7@203691|Spirochaetes	203691|Spirochaetes	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
GDHHQS1_k127_2898679_36	665571.STHERM_c09070	1.669e-47	175.0	COG1815@1|root,COG1815@2|Bacteria,2J804@203691|Spirochaetes	203691|Spirochaetes	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
GDHHQS1_k127_2898679_6	1480694.DC28_02305	1.008e-182	591.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
GDHHQS1_k127_2898679_30	665571.STHERM_c09050	3.683e-72	247.0	COG5405@1|root,COG5405@2|Bacteria,2J608@203691|Spirochaetes	203691|Spirochaetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
GDHHQS1_k127_2898679_33	1118054.CAGW01000001_gene115	1.043e-61	228.0	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli,2722Y@186822|Paenibacillaceae	91061|Bacilli	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_2898679_0	906968.Trebr_0957	2.722e-303	944.0	COG0550@1|root,COG0550@2|Bacteria,2J5BS@203691|Spirochaetes	203691|Spirochaetes	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
GDHHQS1_k127_2898679_32	243275.TDE_1207	8.407e-64	235.0	COG0758@1|root,COG0758@2|Bacteria,2J6UM@203691|Spirochaetes	203691|Spirochaetes	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
GDHHQS1_k127_2898679_39	754027.HMPREF9554_00203	7.858e-33	147.0	COG0457@1|root,COG0457@2|Bacteria,2J7BD@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
GDHHQS1_k127_2898679_26	1123274.KB899413_gene864	7.509e-81	280.0	COG4974@1|root,COG4974@2|Bacteria,2J7GT@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_2898679_10	573413.Spirs_1552	7.756e-157	503.0	COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes	203691|Spirochaetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
GDHHQS1_k127_2898679_9	1123274.KB899413_gene866	8.879e-167	533.0	COG0849@1|root,COG0849@2|Bacteria,2J5UK@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
GDHHQS1_k127_2898679_47	1123274.KB899413_gene867	3.441e-20	101.0	COG1589@1|root,COG1589@2|Bacteria,2J70E@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
GDHHQS1_k127_2898679_25	1307761.L21SP2_1159	1.668e-87	309.0	COG0772@1|root,COG0772@2|Bacteria,2J58T@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
GDHHQS1_k127_2898679_13	545695.TREAZ_0906	1.656e-125	419.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
GDHHQS1_k127_2898679_22	744872.Spica_1686	1.171e-93	329.0	COG0770@1|root,COG0770@2|Bacteria,2J5GH@203691|Spirochaetes	203691|Spirochaetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
GDHHQS1_k127_2898679_56	744872.Spica_1687	4.465e-05	50.0	2BPMB@1|root,32IEC@2|Bacteria,2J8ZG@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein, FtsL	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
GDHHQS1_k127_2898679_21	221027.JO40_13395	1.974e-94	323.0	COG0275@1|root,COG0275@2|Bacteria,2J6DH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
GDHHQS1_k127_2898679_34	665571.STHERM_c08910	1.121e-52	190.0	COG2001@1|root,COG2001@2|Bacteria,2J7XS@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
GDHHQS1_k127_2898679_44	665571.STHERM_c14030	5.479e-25	109.0	COG4517@1|root,COG4517@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1820)	IV02_29925	-	-	-	-	-	-	-	-	-	-	-	DUF1820
GDHHQS1_k127_2898679_49	1123274.KB899413_gene874	2.515e-14	76.0	2AN0A@1|root,2ZDBY@2|Bacteria,2J9A6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_2898679_57	575540.Isop_0372	0.0006633	48.0	COG1366@1|root,COG1366@2|Bacteria,2J02R@203682|Planctomycetes	203682|Planctomycetes	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
GDHHQS1_k127_2898679_41	744872.Spica_1041	1.699e-28	116.0	COG2227@1|root,COG2227@2|Bacteria,2J6CB@203691|Spirochaetes	203691|Spirochaetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
GDHHQS1_k127_2917226_0	1307761.L21SP2_0211	4.125e-168	546.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
GDHHQS1_k127_2917226_1	545694.TREPR_3045	5.057e-67	244.0	COG1653@1|root,COG1653@2|Bacteria,2J5NC@203691|Spirochaetes	203691|Spirochaetes	G	transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
GDHHQS1_k127_2980100_0	1157708.KB907450_gene6460	2.497e-106	361.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2VNNU@28216|Betaproteobacteria,4ACSJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Amidohydrolase 2	-	-	5.4.1.4	ko:K18982	ko00053,map00053	-	R10846	RC03286	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
GDHHQS1_k127_2980100_1	420324.KI912086_gene7328	3.874e-90	299.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JU3D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3,DUF1643
GDHHQS1_k127_3022300_4	768710.DesyoDRAFT_2021	5.56e-14	80.0	COG0845@1|root,COG0845@2|Bacteria,1V156@1239|Firmicutes,24E26@186801|Clostridia	186801|Clostridia	M	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
GDHHQS1_k127_3022300_1	1122917.KB899664_gene2875	2.204e-88	301.0	COG0395@1|root,COG0395@2|Bacteria,1TS82@1239|Firmicutes,4HV22@91061|Bacilli,26SRI@186822|Paenibacillaceae	91061|Bacilli	G	Sugar ABC transporter permease	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_3022300_0	293826.Amet_4743	1.429e-97	326.0	COG1175@1|root,COG1175@2|Bacteria,1TQTC@1239|Firmicutes,24AQX@186801|Clostridia,36GI8@31979|Clostridiaceae	186801|Clostridia	G	ABC transporter, permease protein	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_3022300_2	264732.Moth_2255	2.902e-73	265.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,42EXZ@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
GDHHQS1_k127_3022300_3	557599.MKAN_09185	2.181e-20	95.0	COG1487@1|root,COG1487@2|Bacteria,2GYEI@201174|Actinobacteria,23DTM@1762|Mycobacteriaceae	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
GDHHQS1_k127_3022300_6	1304875.JAFZ01000003_gene568	7.814e-05	47.0	COG0477@1|root,COG2814@2|Bacteria,3TACW@508458|Synergistetes	508458|Synergistetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
GDHHQS1_k127_3041080_0	1379698.RBG1_1C00001G1545	3.254e-129	431.0	COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria	2|Bacteria	KT	PglZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PglZ,Response_reg
GDHHQS1_k127_3044127_3	1499967.BAYZ01000090_gene4960	2.289e-54	196.0	COG1249@1|root,COG1249@2|Bacteria,2NNTI@2323|unclassified Bacteria	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
GDHHQS1_k127_3044127_0	926550.CLDAP_34860	1.992e-128	426.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	pdhC	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
GDHHQS1_k127_3044127_7	1123274.KB899411_gene3131	2.47e-33	132.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3044127_5	1123274.KB899426_gene2832	2.297e-38	163.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
GDHHQS1_k127_3044127_2	665571.STHERM_c01870	4.407e-75	272.0	2EVQY@1|root,33P4X@2|Bacteria,2J6X8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3044127_6	665571.STHERM_c01860	6.946e-37	141.0	COG3118@1|root,COG3118@2|Bacteria,2J865@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
GDHHQS1_k127_3044127_1	744872.Spica_1991	1.403e-76	269.0	COG3858@1|root,COG3858@2|Bacteria,2J6UU@203691|Spirochaetes	203691|Spirochaetes	S	hydrolase, family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
GDHHQS1_k127_3044127_4	552811.Dehly_0206	3.099e-43	162.0	COG0477@1|root,COG0477@2|Bacteria,2G7N2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_3067369_10	324925.Ppha_1272	5.364e-16	80.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
GDHHQS1_k127_3067369_1	573413.Spirs_3823	4.87e-208	670.0	COG1674@1|root,COG1674@2|Bacteria,2J63D@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
GDHHQS1_k127_3067369_6	243276.TPANIC_0043	5.849e-50	202.0	COG0741@1|root,COG0741@2|Bacteria,2J7A5@203691|Spirochaetes	203691|Spirochaetes	M	transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_6
GDHHQS1_k127_3067369_5	1123274.KB899410_gene3463	1.222e-50	192.0	COG1652@1|root,COG1652@2|Bacteria,2J6RK@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70,LysM
GDHHQS1_k127_3067369_3	744872.Spica_0364	2.073e-96	331.0	COG0457@1|root,COG0457@2|Bacteria,2J5RJ@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
GDHHQS1_k127_3067369_8	545695.TREAZ_2579	9.287e-31	141.0	COG0357@1|root,COG0357@2|Bacteria,2J72Y@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
GDHHQS1_k127_3067369_0	665571.STHERM_c02920	3.603e-252	792.0	COG0445@1|root,COG0445@2|Bacteria,2J5A1@203691|Spirochaetes	203691|Spirochaetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
GDHHQS1_k127_3067369_2	665571.STHERM_c02910	3.846e-119	399.0	COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes	203691|Spirochaetes	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
GDHHQS1_k127_3067369_4	1195236.CTER_2292	7.961e-71	253.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,25CI8@186801|Clostridia,3WJ6E@541000|Ruminococcaceae	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
GDHHQS1_k127_3067369_7	1150474.JQJI01000002_gene1119	1.283e-33	138.0	COG2059@1|root,COG2059@2|Bacteria,2GDEW@200918|Thermotogae	200918|Thermotogae	P	PFAM Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
GDHHQS1_k127_3067369_9	309803.CTN_0750	1.191e-23	111.0	COG2059@1|root,COG2059@2|Bacteria,2GD9V@200918|Thermotogae	200918|Thermotogae	P	PFAM Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
GDHHQS1_k127_3088202_3	889378.Spiaf_1722	6.017e-70	249.0	COG0679@1|root,COG0679@2|Bacteria,2J8BY@203691|Spirochaetes	203691|Spirochaetes	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
GDHHQS1_k127_3088202_6	697281.Mahau_0030	0.0001203	51.0	28MXM@1|root,2ZB4M@2|Bacteria,1V0PQ@1239|Firmicutes,24ENW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3088202_4	1232453.BAIF02000062_gene1902	7.898e-12	78.0	28MXM@1|root,2ZB4M@2|Bacteria,1UYF1@1239|Firmicutes,24DFA@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3088202_5	1267535.KB906767_gene2719	1.304e-10	73.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.1.1.102	ko:K06978,ko:K21105	-	-	R11541	RC00020,RC00041	ko00000,ko01000	-	-	-	AXE1,Big_5,LTD,Peptidase_S9,Tannase
GDHHQS1_k127_3088202_1	1499967.BAYZ01000119_gene3200	8.457e-145	465.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
GDHHQS1_k127_3088202_2	880073.Calab_3447	5.378e-131	430.0	COG1373@1|root,COG1373@2|Bacteria,2NP9F@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
GDHHQS1_k127_3088202_0	1142394.PSMK_17850	8.037e-225	720.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_106
GDHHQS1_k127_3205344_1	1480694.DC28_15195	5.143e-112	377.0	COG0168@1|root,COG0168@2|Bacteria,2J5NF@203691|Spirochaetes	203691|Spirochaetes	P	Potassium uptake protein, TrkH family	ntpJ	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
GDHHQS1_k127_3205344_3	1480694.DC28_15190	8.805e-62	225.0	COG0569@1|root,COG0569@2|Bacteria,2J7SR@203691|Spirochaetes	203691|Spirochaetes	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
GDHHQS1_k127_3205344_2	926569.ANT_02890	4.527e-101	338.0	COG1738@1|root,COG1738@2|Bacteria,2G6BZ@200795|Chloroflexi	200795|Chloroflexi	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
GDHHQS1_k127_3205344_4	439292.Bsel_1271	9.298e-13	81.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	ytxJ	-	-	ko:K20541,ko:K20543	-	-	-	-	ko00000,ko02000	1.B.55.3,4.D.3.1.6	-	-	DUF2847
GDHHQS1_k127_3205344_0	1499967.BAYZ01000009_gene5236	1.36e-126	419.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_7,DLH,Peptidase_S9
GDHHQS1_k127_3205344_5	926550.CLDAP_28790	1.577e-12	75.0	COG0477@1|root,COG2814@2|Bacteria,2GBP2@200795|Chloroflexi	200795|Chloroflexi	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_3238036_10	1120949.KB903294_gene4470	7.696e-19	93.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_3238036_0	697281.Mahau_1770	0.0	1153.0	COG3250@1|root,COG3250@2|Bacteria,1TRU4@1239|Firmicutes,24B1J@186801|Clostridia,42F6Q@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM glycoside hydrolase family 2 sugar binding	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
GDHHQS1_k127_3238036_7	1536770.R50345_05335	3.391e-60	230.0	COG0395@1|root,COG0395@2|Bacteria,1TS0D@1239|Firmicutes,4HA5Y@91061|Bacilli,26R41@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_3238036_2	697281.Mahau_1774	1.635e-143	462.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,24AW8@186801|Clostridia,42F0M@68295|Thermoanaerobacterales	1239|Firmicutes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_3238036_1	697281.Mahau_1775	1.572e-179	575.0	COG1653@1|root,COG1653@2|Bacteria,1V6BR@1239|Firmicutes,251TX@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_8
GDHHQS1_k127_3238036_12	1279017.AQYJ01000023_gene3265	2.553e-07	63.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	2.4.1.10	ko:K00692	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R05140	RC00077	ko00000,ko00001,ko01000,ko01003	-	GH68	-	Alpha-L-AF_C,Alpha-amylase,Big_2,CBM_4_9,Glyco_hydro_32N,Glyco_hydro_43,Glyco_hydro_66,Glyco_hydro_68,Laminin_G_3,PUD,SLH,VCBS
GDHHQS1_k127_3238036_5	1229172.JQFA01000002_gene4789	3.863e-71	259.0	COG3693@1|root,COG3693@2|Bacteria,1GI7D@1117|Cyanobacteria,1HE3X@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolase family 10	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_10
GDHHQS1_k127_3238036_9	411468.CLOSCI_00839	1.462e-40	169.0	COG2159@1|root,COG2159@2|Bacteria,1UEFI@1239|Firmicutes,25JCC@186801|Clostridia,2222C@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
GDHHQS1_k127_3238036_3	573413.Spirs_1915	1.444e-132	447.0	COG1449@1|root,COG1449@2|Bacteria,2J5C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
GDHHQS1_k127_3238036_11	596330.HMPREF0628_0509	3.409e-11	76.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,22GV5@1570339|Peptoniphilaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
GDHHQS1_k127_3238036_13	760011.Spico_0534	2.427e-06	61.0	COG4660@1|root,COG4660@2|Bacteria	2|Bacteria	C	electron transport chain	rnfE	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	2.3.1.243,4.2.99.18	ko:K02560,ko:K03613,ko:K10773	ko00540,ko01100,ko03410,map00540,map01100,map03410	M00060	R05075	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005,ko03400	-	-	iHN637.CLJU_RS05585	Rnf-Nqr
GDHHQS1_k127_3238036_6	573413.Spirs_1910	8.109e-65	245.0	COG4658@1|root,COG4658@2|Bacteria,2J639@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
GDHHQS1_k127_3238036_4	1123274.KB899415_gene2518	1.29e-73	264.0	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
GDHHQS1_k127_3238036_8	1480694.DC28_14730	8.571e-44	164.0	COG1963@1|root,COG1963@2|Bacteria,2J7WX@203691|Spirochaetes	203691|Spirochaetes	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
GDHHQS1_k127_3368815_0	243231.GSU2758	4.085e-239	751.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
GDHHQS1_k127_3368815_4	1223542.GM1_007_01010	1.26e-17	91.0	COG1848@1|root,COG1848@2|Bacteria,2H7T3@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_3368815_6	1032480.MLP_04400	6.125e-05	48.0	COG4691@1|root,COG4691@2|Bacteria,2HB2Z@201174|Actinobacteria,4DW0R@85009|Propionibacteriales	201174|Actinobacteria	S	Plasmid stability protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3368815_5	497964.CfE428DRAFT_3099	2.06e-15	79.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
GDHHQS1_k127_3368815_3	1304865.JAGF01000001_gene1578	1.111e-87	302.0	28PJ3@1|root,2ZC8W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3368815_2	1283284.AZUK01000001_gene284	7.132e-88	299.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1Y61V@135624|Aeromonadales	135624|Aeromonadales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
GDHHQS1_k127_3368815_1	1123508.JH636445_gene6496	1.563e-92	319.0	COG5337@1|root,COG5337@2|Bacteria,2IYR8@203682|Planctomycetes	203682|Planctomycetes	M	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
GDHHQS1_k127_3374127_1	767434.Fraau_0918	2.267e-53	204.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1X40W@135614|Xanthomonadales	135614|Xanthomonadales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
GDHHQS1_k127_3374127_0	1254432.SCE1572_42245	2.845e-72	257.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2YU2F@29|Myxococcales	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
GDHHQS1_k127_3404890_11	401526.TcarDRAFT_1522	1.5e-76	266.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
GDHHQS1_k127_3404890_5	665571.STHERM_c21630	1.049e-123	412.0	COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes	203691|Spirochaetes	G	transporter	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
GDHHQS1_k127_3404890_25	1123274.KB899407_gene358	5.236e-10	68.0	COG0745@1|root,COG0745@2|Bacteria	1123274.KB899407_gene358|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3404890_13	545695.TREAZ_2703	2.165e-69	242.0	COG1842@1|root,COG1842@2|Bacteria,2J5MH@203691|Spirochaetes	203691|Spirochaetes	KT	Phage shock protein A	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
GDHHQS1_k127_3404890_20	545694.TREPR_0065	9.619e-28	124.0	2E9HN@1|root,333QR@2|Bacteria,2J8QF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3404890_9	573413.Spirs_0140	3.975e-99	328.0	COG1366@1|root,COG1366@2|Bacteria,2J6J8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
GDHHQS1_k127_3404890_14	1123274.KB899422_gene107	1.662e-57	218.0	COG0565@1|root,COG0565@2|Bacteria,2J6NV@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
GDHHQS1_k127_3404890_10	941449.dsx2_1429	4.675e-79	299.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_3404890_0	688269.Theth_1511	1.143e-194	627.0	COG5012@1|root,COG5012@2|Bacteria,2GCEQ@200918|Thermotogae	200918|Thermotogae	S	PFAM cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Met_asp_mut_E
GDHHQS1_k127_3404890_6	1047013.AQSP01000075_gene1429	2.948e-120	402.0	COG0240@1|root,COG0240@2|Bacteria	2|Bacteria	I	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	odh	-	1.5.1.28	ko:K04940	-	-	-	-	ko00000,ko01000	-	-	-	ApbA,F420_oxidored,NAD_Gly3P_dh_N,NAD_binding_2,Octopine_DH
GDHHQS1_k127_3404890_23	671143.DAMO_1538	1.348e-19	98.0	COG0668@1|root,COG0668@2|Bacteria,2NQ6B@2323|unclassified Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
GDHHQS1_k127_3404890_17	926569.ANT_06070	2.766e-40	171.0	COG1181@1|root,COG1181@2|Bacteria,2G5RS@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
GDHHQS1_k127_3404890_22	889378.Spiaf_2775	7.959e-22	101.0	COG3030@1|root,COG3030@2|Bacteria	2|Bacteria	S	protein affecting phage T7 exclusion by the F plasmid	fxsA	-	2.3.3.13	ko:K01649,ko:K07113	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	FxsA
GDHHQS1_k127_3404890_18	754027.HMPREF9554_00486	3.352e-38	160.0	COG1922@1|root,COG1922@2|Bacteria,2J6M5@203691|Spirochaetes	203691|Spirochaetes	M	WecB TagA CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
GDHHQS1_k127_3404890_19	744872.Spica_0238	1.55e-34	151.0	COG1385@1|root,COG1385@2|Bacteria,2J7WH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
GDHHQS1_k127_3404890_8	889378.Spiaf_2778	1.382e-110	383.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
GDHHQS1_k127_3404890_16	744872.Spica_2300	1.285e-43	181.0	COG0785@1|root,COG0785@2|Bacteria,2JA8R@203691|Spirochaetes	203691|Spirochaetes	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3404890_7	665571.STHERM_c00350	8.656e-114	387.0	COG0682@1|root,COG0682@2|Bacteria,2J58I@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
GDHHQS1_k127_3404890_1	118005.AWNK01000006_gene1380	1.618e-167	535.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	nifS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
GDHHQS1_k127_3404890_3	273121.WS2205	3.364e-135	438.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	-	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
GDHHQS1_k127_3404890_26	232348.ADXL01000039_gene1655	2.472e-09	69.0	COG2197@1|root,COG2197@2|Bacteria,1G7V9@1117|Cyanobacteria,1H1BB@1129|Synechococcus	1117|Cyanobacteria	K	transcriptional regulator	csgD	-	-	-	-	-	-	-	-	-	-	-	GerE
GDHHQS1_k127_3404890_29	1128398.Curi_c21900	8.238e-05	49.0	COG2339@1|root,COG2339@2|Bacteria,1UZGQ@1239|Firmicutes,24D4U@186801|Clostridia	186801|Clostridia	S	Protease prsW family	prsW	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
GDHHQS1_k127_3404890_27	1306406.ASHX01000002_gene5193	6.369e-09	66.0	COG0596@1|root,COG0596@2|Bacteria,2GK43@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
GDHHQS1_k127_3404890_24	485913.Krac_4110	6.982e-15	76.0	2DRAK@1|root,33AYS@2|Bacteria	485913.Krac_4110|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3404890_4	926560.KE387023_gene2413	8.081e-133	448.0	COG2936@1|root,COG2936@2|Bacteria,1WN5B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
GDHHQS1_k127_3404890_21	1040982.AXAL01000029_gene4283	1.452e-27	132.0	COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1NIJG@1224|Proteobacteria,2U09P@28211|Alphaproteobacteria,43PM5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IT	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,BTAD,Hydrolase_4,Trans_reg_C
GDHHQS1_k127_3404890_2	42256.RradSPS_0358	1.324e-152	524.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
GDHHQS1_k127_3404890_15	665571.STHERM_c00280	8.299e-56	202.0	COG0170@1|root,COG0170@2|Bacteria,2J6YY@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA_1	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3404890_12	926569.ANT_01870	6.609e-73	254.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi	200795|Chloroflexi	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
GDHHQS1_k127_3488836_1	1480694.DC28_14400	4.486e-97	324.0	COG0081@1|root,COG0081@2|Bacteria,2J5HN@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
GDHHQS1_k127_3488836_5	665571.STHERM_c04860	1.07e-59	210.0	COG0080@1|root,COG0080@2|Bacteria,2J7BU@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
GDHHQS1_k127_3488836_3	1123274.KB899411_gene3124	1.695e-81	279.0	COG0250@1|root,COG0250@2|Bacteria,2J7FV@203691|Spirochaetes	203691|Spirochaetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
GDHHQS1_k127_3488836_9	889378.Spiaf_0542	2.581e-16	79.0	COG0690@1|root,COG0690@2|Bacteria,2J9CX@203691|Spirochaetes	203691|Spirochaetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
GDHHQS1_k127_3488836_8	243275.TDE_2428	9.085e-18	84.0	COG0267@1|root,COG0267@2|Bacteria,2J8UW@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
GDHHQS1_k127_3488836_6	596324.TREVI0001_1169	1.049e-45	171.0	COG0742@1|root,COG0742@2|Bacteria,2J7B5@203691|Spirochaetes	203691|Spirochaetes	L	RNA methyltransferase, RsmD family	yhhF	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
GDHHQS1_k127_3488836_0	665571.STHERM_c08070	4.711e-187	608.0	COG1200@1|root,COG1200@2|Bacteria,2J5ET@203691|Spirochaetes	203691|Spirochaetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
GDHHQS1_k127_3488836_7	665571.STHERM_c08080	2.753e-19	102.0	COG0762@1|root,COG0762@2|Bacteria,2J8K1@203691|Spirochaetes	203691|Spirochaetes	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
GDHHQS1_k127_3488836_4	941449.dsx2_0980	2.984e-65	240.0	COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2M8EF@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
GDHHQS1_k127_3488836_2	289376.THEYE_A1986	2.397e-92	323.0	COG0460@1|root,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae	40117|Nitrospirae	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
GDHHQS1_k127_3557257_3	545695.TREAZ_2559	3.705e-55	215.0	2BXG3@1|root,2Z82R@2|Bacteria,2J6D3@203691|Spirochaetes	203691|Spirochaetes	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
GDHHQS1_k127_3557257_0	756272.Plabr_2258	1.32e-142	467.0	COG3875@1|root,COG3875@2|Bacteria,2IY1E@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
GDHHQS1_k127_3557257_1	665956.HMPREF1032_02344	5.739e-97	333.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,3WIGS@541000|Ruminococcaceae	186801|Clostridia	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
GDHHQS1_k127_3557257_2	771875.Ferpe_1310	3.174e-72	254.0	COG0778@1|root,COG0778@2|Bacteria,2GCST@200918|Thermotogae	200918|Thermotogae	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS1_k127_3557257_5	717606.PaecuDRAFT_0919	6.38e-12	78.0	COG1472@1|root,COG2133@1|root,COG2273@1|root,COG1472@2|Bacteria,COG2133@2|Bacteria,COG2273@2|Bacteria,1VTMV@1239|Firmicutes,4HTQP@91061|Bacilli,27225@186822|Paenibacillaceae	91061|Bacilli	G	Cellulose Binding Domain Type IV	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,CHB_HEX_C_1,F5_F8_type_C,Glyco_hydro_3,Glyco_hydro_3_C
GDHHQS1_k127_3557257_4	1279009.ADICEAN_02033	8.738e-48	187.0	COG0793@1|root,COG0793@2|Bacteria,4NFEN@976|Bacteroidetes,47PTG@768503|Cytophagia	976|Bacteroidetes	M	PFAM Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,Tricorn_C1
GDHHQS1_k127_3615439_2	1121904.ARBP01000005_gene4576	3.572e-08	64.0	COG0457@1|root,COG4251@1|root,COG0457@2|Bacteria,COG4251@2|Bacteria,4P2C8@976|Bacteroidetes,47UN6@768503|Cytophagia	976|Bacteroidetes	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,TPR_12
GDHHQS1_k127_3615439_1	573413.Spirs_1730	3.404e-61	232.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J7KD@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
GDHHQS1_k127_3615439_0	665571.STHERM_c07150	2.238e-267	846.0	COG5009@1|root,COG5009@2|Bacteria,2J5D4@203691|Spirochaetes	203691|Spirochaetes	M	penicillin-binding protein	pbp-3	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
GDHHQS1_k127_3669539_3	768706.Desor_1551	5.502e-11	68.0	28HF7@1|root,2ZAT5@2|Bacteria,1VT0D@1239|Firmicutes,24XG8@186801|Clostridia	186801|Clostridia	C	PFAM Glycine sarcosine betaine reductase component B subunits	-	-	-	-	-	-	-	-	-	-	-	-	Gly_reductase
GDHHQS1_k127_3669539_2	243275.TDE_0078	1.33e-21	96.0	COG1978@1|root,COG1978@2|Bacteria,2J9P4@203691|Spirochaetes	203691|Spirochaetes	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
GDHHQS1_k127_3669539_0	2754.EH55_02225	1.132e-102	346.0	COG1978@1|root,COG1978@2|Bacteria,3TA3Z@508458|Synergistetes	508458|Synergistetes	S	Selenoprotein B, glycine betaine sarcosine D-proline reductase family	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
GDHHQS1_k127_3669539_1	204669.Acid345_2237	3.49e-85	290.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
GDHHQS1_k127_3725314_5	744872.Spica_2595	2.722e-98	328.0	COG1916@1|root,COG1916@2|Bacteria,2J5K2@203691|Spirochaetes	203691|Spirochaetes	S	Pheromone shutdown protein	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
GDHHQS1_k127_3725314_10	278957.ABEA03000135_gene1776	5.154e-60	223.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_3725314_6	1121335.Clst_0993	6.836e-96	325.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_3725314_9	697281.Mahau_1773	5.41e-66	254.0	COG0395@1|root,COG0395@2|Bacteria,1TSX2@1239|Firmicutes,24891@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K17320	ko02010,map02010	M00207,M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_3725314_13	324057.Pjdr2_0746	3.599e-57	219.0	COG1653@1|root,COG1653@2|Bacteria,1UNAN@1239|Firmicutes,4HT4T@91061|Bacilli,26U4B@186822|Paenibacillaceae	91061|Bacilli	G	extracellular solute-binding protein, family 1	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
GDHHQS1_k127_3725314_7	204669.Acid345_4388	5.645e-91	317.0	2DUQS@1|root,33RT2@2|Bacteria,3Y6EQ@57723|Acidobacteria,2JMHN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3725314_11	743719.PaelaDRAFT_1265	8.535e-59	224.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HI3Z@91061|Bacilli,26T2X@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
GDHHQS1_k127_3725314_12	742733.HMPREF9469_03371	4.441e-58	230.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,21XTZ@1506553|Lachnoclostridium	186801|Clostridia	T	signal transduction protein with a C-terminal ATPase domain	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
GDHHQS1_k127_3725314_3	1267535.KB906767_gene5008	3.277e-137	484.0	COG4447@1|root,COG4447@2|Bacteria,3Y2MX@57723|Acidobacteria,2JMA6@204432|Acidobacteriia	204432|Acidobacteriia	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3725314_15	324057.Pjdr2_0746	3.391e-37	161.0	COG1653@1|root,COG1653@2|Bacteria,1UNAN@1239|Firmicutes,4HT4T@91061|Bacilli,26U4B@186822|Paenibacillaceae	91061|Bacilli	G	extracellular solute-binding protein, family 1	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
GDHHQS1_k127_3725314_8	439235.Dalk_5096	1.398e-75	261.0	COG0138@1|root,COG0138@2|Bacteria,1N2UC@1224|Proteobacteria,42NFS@68525|delta/epsilon subdivisions,2X5JJ@28221|Deltaproteobacteria,2MIV7@213118|Desulfobacterales	28221|Deltaproteobacteria	F	MGS-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AICARFT_IMPCHas,MGS
GDHHQS1_k127_3725314_1	96561.Dole_1516	1.449e-168	551.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
GDHHQS1_k127_3725314_2	1121346.KB899818_gene2604	3.411e-150	481.0	COG3458@1|root,COG3458@2|Bacteria,1TS02@1239|Firmicutes,4HDID@91061|Bacilli,26QEJ@186822|Paenibacillaceae	91061|Bacilli	Q	Acetyl esterase	cah	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
GDHHQS1_k127_3725314_0	1499967.BAYZ01000061_gene5973	4.897e-200	644.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	2.1.2.1,2.2.1.8	ko:K00600,ko:K18847	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
GDHHQS1_k127_3725314_4	439235.Dalk_0661	1.161e-115	389.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	fgrM	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_3725314_14	1219084.AP014508_gene124	4.653e-40	163.0	COG3437@1|root,COG3437@2|Bacteria,2GCQ2@200918|Thermotogae	200918|Thermotogae	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5,Response_reg
GDHHQS1_k127_3725314_16	1289387.AUKW01000010_gene1065	4.389e-19	102.0	COG2407@1|root,COG2407@2|Bacteria,2I7YU@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the conversion of L-arabinose to L-ribulose	-	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Isome,Fucose_iso_C
GDHHQS1_k127_3726523_1	1304880.JAGB01000001_gene542	1.561e-57	217.0	COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_3726523_3	1226325.HMPREF1548_06805	4.783e-21	109.0	COG4126@1|root,COG4126@2|Bacteria,1UKAT@1239|Firmicutes,25GR6@186801|Clostridia,36NCF@31979|Clostridiaceae	186801|Clostridia	E	Asp/Glu/Hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
GDHHQS1_k127_3726523_2	1391647.AVSV01000018_gene793	5.894e-51	203.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,36E9P@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	tktB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_3726523_0	1121428.DESHY_110537___1	6.892e-60	220.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
GDHHQS1_k127_3726523_4	1123023.JIAI01000004_gene7912	1.688e-05	53.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K11476	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR,Phg_2220_C
GDHHQS1_k127_3759554_0	243231.GSU3266	2.617e-248	810.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,43SUF@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
GDHHQS1_k127_3759554_3	1123274.KB899411_gene3194	2.211e-28	128.0	2E1WK@1|root,3307R@2|Bacteria,2JBFS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3759554_2	1499967.BAYZ01000171_gene5596	2.173e-31	131.0	COG0212@1|root,COG0212@2|Bacteria	2|Bacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	5-FTHF_cyc-lig
GDHHQS1_k127_3759554_1	660470.Theba_0060	2.347e-36	145.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
GDHHQS1_k127_390907_10	1536772.R70723_10405	5.842e-38	145.0	COG3345@1|root,COG3345@2|Bacteria,1TSZB@1239|Firmicutes,4HDHK@91061|Bacilli,26S92@186822|Paenibacillaceae	91061|Bacilli	G	alpha-galactosidase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36N,Melibiase
GDHHQS1_k127_390907_7	1288963.ADIS_1362	1.085e-66	239.0	COG3836@1|root,COG3836@2|Bacteria,4NH2V@976|Bacteroidetes,47JVN@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52,4.1.2.53	ko:K01630,ko:K02510,ko:K12660	ko00051,ko00053,ko00350,ko01120,map00051,map00053,map00350,map01120	-	R01645,R01647,R02261,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
GDHHQS1_k127_390907_6	1380390.JIAT01000013_gene3	2.133e-69	247.0	COG1052@1|root,COG1052@2|Bacteria,2I869@201174|Actinobacteria	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GDHHQS1_k127_390907_0	1307761.L21SP2_3489	3.476e-259	826.0	COG0064@1|root,COG0064@2|Bacteria,2J58X@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
GDHHQS1_k127_390907_3	1123274.KB899411_gene3029	7.685e-137	451.0	COG0154@1|root,COG0154@2|Bacteria,2J58P@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
GDHHQS1_k127_390907_14	1480694.DC28_08865	5.251e-17	85.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
GDHHQS1_k127_390907_1	1480694.DC28_08870	7.319e-200	632.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
GDHHQS1_k127_390907_2	1304880.JAGB01000002_gene2262	9.935e-157	506.0	COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia	186801|Clostridia	E	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_390907_4	1034769.KB910518_gene2305	9.581e-101	336.0	COG3828@1|root,COG3828@2|Bacteria,1TT0R@1239|Firmicutes,4HDKB@91061|Bacilli,26S6M@186822|Paenibacillaceae	91061|Bacilli	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
GDHHQS1_k127_390907_13	1111730.ATTM01000001_gene1684	2.931e-20	105.0	COG5276@1|root,COG5276@2|Bacteria,4NIBK@976|Bacteroidetes,1I07Z@117743|Flavobacteriia,2NS89@237|Flavobacterium	976|Bacteroidetes	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
GDHHQS1_k127_390907_16	926569.ANT_01500	2.443e-06	50.0	COG1132@1|root,COG1132@2|Bacteria,2G5RC@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_390907_5	525904.Tter_2350	1.689e-88	319.0	COG1132@1|root,COG1132@2|Bacteria,2NNP8@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_390907_8	794903.OPIT5_07690	6.85e-66	252.0	COG3170@1|root,COG3170@2|Bacteria,46Y8C@74201|Verrucomicrobia,3K93X@414999|Opitutae	414999|Opitutae	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_390907_9	1499967.BAYZ01000131_gene337	4.882e-59	213.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_390907_11	1499967.BAYZ01000131_gene337	1.326e-24	106.0	COG0399@1|root,COG0399@2|Bacteria,2NQH7@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_390907_12	797210.Halxa_0140	1.168e-22	111.0	arCOG13341@1|root,arCOG13341@2157|Archaea,2XXWE@28890|Euryarchaeota,23WKG@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_390907_15	69014.TK0722	3.718e-08	65.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y18C@28890|Euryarchaeota,24481@183968|Thermococci	183968|Thermococci	O	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
GDHHQS1_k127_3926745_5	588581.Cpap_3503	3.31e-46	181.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3WH8U@541000|Ruminococcaceae	186801|Clostridia	G	beta-galactosidase	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
GDHHQS1_k127_3926745_7	1126627.BAWE01000002_gene44	6.172e-21	109.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TU52@28211|Alphaproteobacteria,3JSN7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	CHASE2	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
GDHHQS1_k127_3926745_9	78245.Xaut_1091	1.1e-08	69.0	COG1404@1|root,COG1404@2|Bacteria,1R5H7@1224|Proteobacteria,2UEP3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
GDHHQS1_k127_3926745_8	1201290.M902_2199	6.433e-09	70.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Flg_new,PKD,SprB
GDHHQS1_k127_3926745_4	545694.TREPR_2780	3.544e-87	314.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3926745_0	929556.Solca_3465	2.507e-185	596.0	COG1132@1|root,COG1132@2|Bacteria,4NEBS@976|Bacteroidetes,1IPPE@117747|Sphingobacteriia	976|Bacteroidetes	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_3926745_10	219305.MCAG_04051	5.579e-05	57.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DAB5@85008|Micromonosporales	201174|Actinobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_4,PAS_8
GDHHQS1_k127_3926745_1	1379698.RBG1_1C00001G1661	2.485e-180	578.0	COG1239@1|root,COG1239@2|Bacteria,2NQQG@2323|unclassified Bacteria	2|Bacteria	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
GDHHQS1_k127_3926745_2	1379698.RBG1_1C00001G1660	4.973e-125	410.0	COG4867@1|root,COG4867@2|Bacteria,2NQZ8@2323|unclassified Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
GDHHQS1_k127_3926745_6	604331.AUHY01000103_gene2121	2.26e-38	153.0	COG4096@1|root,COG4096@2|Bacteria	2|Bacteria	L	type I site-specific deoxyribonuclease activity	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
GDHHQS1_k127_3926745_3	700598.Niako_7160	1.377e-98	331.0	COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,4NEGN@976|Bacteroidetes,1IRIW@117747|Sphingobacteriia	976|Bacteroidetes	S	Virulence protein RhuM family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Virulence_RhuM
GDHHQS1_k127_3964162_7	1123274.KB899431_gene3279	2.07e-39	149.0	COG1774@1|root,COG1774@2|Bacteria,2J5RE@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
GDHHQS1_k127_3964162_1	1304880.JAGB01000002_gene2264	1.19e-119	404.0	2DBSS@1|root,2ZATI@2|Bacteria,1V13H@1239|Firmicutes,24D92@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
GDHHQS1_k127_3964162_2	1304880.JAGB01000002_gene2265	2.658e-107	364.0	COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia	186801|Clostridia	N	-transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_transp_aux
GDHHQS1_k127_3964162_3	1304880.JAGB01000002_gene2266	1.691e-89	304.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia	186801|Clostridia	N	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5
GDHHQS1_k127_3964162_0	1304880.JAGB01000002_gene2267	1.392e-124	407.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_3964162_8	621372.ACIH01000009_gene3788	1.814e-38	153.0	COG1011@1|root,COG1011@2|Bacteria,1TWM7@1239|Firmicutes,4HEXU@91061|Bacilli,2766F@186822|Paenibacillaceae	91061|Bacilli	S	HAD-hyrolase-like	yfnB	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
GDHHQS1_k127_3964162_10	744872.Spica_1612	1.779e-18	87.0	2ERI0@1|root,33J3G@2|Bacteria,2J8XU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_3964162_5	1123250.KB908403_gene631	8.033e-59	231.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,4H2GR@909932|Negativicutes	909932|Negativicutes	H	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
GDHHQS1_k127_3964162_6	545695.TREAZ_2997	2.075e-40	164.0	COG1215@1|root,COG1215@2|Bacteria,2J6KZ@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GDHHQS1_k127_3964162_9	573413.Spirs_1683	6.563e-30	134.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
GDHHQS1_k127_3964162_4	401526.TcarDRAFT_2560	2.645e-71	247.0	2BXG3@1|root,2Z82R@2|Bacteria,1TQT7@1239|Firmicutes,4H6G6@909932|Negativicutes	909932|Negativicutes	S	tagaturonate epimerase	-	-	-	-	-	-	-	-	-	-	-	-	UxaE
GDHHQS1_k127_4016954_18	518766.Rmar_0689	2.25e-54	217.0	COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes	976|Bacteroidetes	G	Alpha-L-rhamnosidase N-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
GDHHQS1_k127_4016954_4	1047013.AQSP01000095_gene2314	2.485e-111	388.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,NMO
GDHHQS1_k127_4016954_1	1131814.JAFO01000001_gene1383	3.771e-169	556.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,3F09H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
GDHHQS1_k127_4016954_10	632518.Calow_2148	1.437e-83	292.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_4016954_26	324057.Pjdr2_1936	3.878e-14	86.0	COG1653@1|root,COG1653@2|Bacteria,1TRF2@1239|Firmicutes,4HAS7@91061|Bacilli,26RAJ@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_4016954_14	1122919.KB905624_gene94	3.444e-73	258.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,4HATZ@91061|Bacilli,26R7F@186822|Paenibacillaceae	91061|Bacilli	G	ABC-type polysaccharide transport system, permease component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_4016954_13	351627.Csac_2553	1.665e-74	260.0	COG0395@1|root,COG0395@2|Bacteria,1TSKG@1239|Firmicutes,25C53@186801|Clostridia,42HT0@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_4016954_3	1304874.JAFY01000002_gene790	3.592e-113	394.0	COG5002@1|root,COG5002@2|Bacteria,3T9XA@508458|Synergistetes	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
GDHHQS1_k127_4016954_12	1304874.JAFY01000002_gene791	9.135e-77	279.0	COG0745@1|root,COG0745@2|Bacteria,3TAJR@508458|Synergistetes	1304874.JAFY01000002_gene791|-	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4016954_2	1121472.AQWN01000007_gene1130	6.744e-114	377.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_4016954_8	1449126.JQKL01000003_gene1820	1.409e-89	307.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,26A0H@186813|unclassified Clostridiales	186801|Clostridia	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
GDHHQS1_k127_4016954_23	717606.PaecuDRAFT_0708	4.626e-36	144.0	COG0279@1|root,COG0279@2|Bacteria,1V610@1239|Firmicutes,4HJH3@91061|Bacilli,272R8@186822|Paenibacillaceae	91061|Bacilli	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
GDHHQS1_k127_4016954_0	1122925.KB895381_gene3889	1.234e-240	762.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,4HB1D@91061|Bacilli,26TU3@186822|Paenibacillaceae	91061|Bacilli	G	Domain of unknown function (DUF5110)	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,DUF5110,F5_F8_type_C,Gal_mutarotas_2,Glyco_hydro_31
GDHHQS1_k127_4016954_19	234267.Acid_6336	3.881e-53	206.0	COG2017@1|root,COG2017@2|Bacteria,3Y6TJ@57723|Acidobacteria	57723|Acidobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4016954_20	269482.Bcep1808_5173	1.551e-49	198.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1K1BU@119060|Burkholderiaceae	28216|Betaproteobacteria	NT	Chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K03776,ko:K05874,ko:K05875	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,TarH,sCache_2
GDHHQS1_k127_4016954_22	390989.JOEG01000030_gene1702	1.785e-43	181.0	COG1595@1|root,COG1595@2|Bacteria,2GK6V@201174|Actinobacteria	201174|Actinobacteria	K	GxGYxYP putative glycoside hydrolase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GxGYxYP_C,GxGYxYP_N
GDHHQS1_k127_4016954_29	561175.KB894096_gene427	1.019e-09	72.0	COG4587@1|root,COG4587@2|Bacteria,2GKX7@201174|Actinobacteria,4EHB4@85012|Streptosporangiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
GDHHQS1_k127_4016954_21	755731.Clo1100_3652	1.25e-47	191.0	COG3694@1|root,COG3694@2|Bacteria,1TR4N@1239|Firmicutes,24A3T@186801|Clostridia,36E7Y@31979|Clostridiaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
GDHHQS1_k127_4016954_6	292459.STH2664	9.864e-106	357.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS1_k127_4016954_27	1121013.P873_11020	1.149e-13	75.0	COG1598@1|root,COG1598@2|Bacteria,1NBIX@1224|Proteobacteria,1SCV3@1236|Gammaproteobacteria,1XBIM@135614|Xanthomonadales	135614|Xanthomonadales	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
GDHHQS1_k127_4016954_24	187303.BN69_1560	4.283e-16	85.0	COG1724@1|root,COG1724@2|Bacteria,1N7S3@1224|Proteobacteria,2UGAG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	N	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
GDHHQS1_k127_4016954_25	1121930.AQXG01000011_gene1730	3.357e-15	87.0	COG0697@1|root,COG0697@2|Bacteria,4PJ9B@976|Bacteroidetes,1IZEH@117747|Sphingobacteriia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS1_k127_4016954_28	1123226.KB899311_gene1758	9.105e-12	78.0	COG1653@1|root,COG1653@2|Bacteria,1TRF2@1239|Firmicutes,4HAS7@91061|Bacilli,26RAJ@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	lplA7	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_4016954_15	697281.Mahau_1331	2.692e-72	258.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_4016954_16	351627.Csac_2553	1.821e-68	243.0	COG0395@1|root,COG0395@2|Bacteria,1TSKG@1239|Firmicutes,25C53@186801|Clostridia,42HT0@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_4016954_5	1304880.JAGB01000002_gene2267	3.393e-110	365.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_4016954_11	1304880.JAGB01000002_gene2266	6.322e-79	272.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia	186801|Clostridia	N	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5
GDHHQS1_k127_4016954_9	1304880.JAGB01000002_gene2265	5.603e-86	304.0	COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia	186801|Clostridia	N	-transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_transp_aux
GDHHQS1_k127_4016954_17	697281.Mahau_2214	3.353e-56	224.0	2DBSS@1|root,2ZATI@2|Bacteria,1V13H@1239|Firmicutes,24D92@186801|Clostridia,42J9A@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
GDHHQS1_k127_4016954_7	697281.Mahau_1771	1.866e-91	311.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_4021036_0	1288494.EBAPG3_30800	3.452e-161	512.0	COG0620@1|root,COG0620@2|Bacteria,1PWDP@1224|Proteobacteria,2WBYB@28216|Betaproteobacteria,3740I@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
GDHHQS1_k127_4021036_1	323848.Nmul_A1491	3.062e-145	482.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WHHA@28216|Betaproteobacteria,371XP@32003|Nitrosomonadales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_7,Response_reg
GDHHQS1_k127_4021036_2	675635.Psed_0935	4.42e-10	61.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4E0TD@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS1_k127_4025811_13	153721.MYP_3053	4.517e-39	153.0	COG0443@1|root,COG0443@2|Bacteria,4NHX7@976|Bacteroidetes,47M2C@768503|Cytophagia	976|Bacteroidetes	O	Hsp70 protein	-	-	-	ko:K04046	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
GDHHQS1_k127_4025811_3	1453496.AT03_07355	1.961e-148	476.0	COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,1RMIG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	reductase	yghZ	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
GDHHQS1_k127_4025811_9	868131.MSWAN_1874	6.883e-68	238.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
GDHHQS1_k127_4025811_6	397291.C804_04716	3.803e-85	296.0	COG1453@1|root,COG1453@2|Bacteria,1TPBG@1239|Firmicutes,2497N@186801|Clostridia,27JCG@186928|unclassified Lachnospiraceae	186801|Clostridia	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4_17
GDHHQS1_k127_4025811_2	1123376.AUIU01000013_gene1818	2.294e-171	543.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
GDHHQS1_k127_4025811_11	443254.Marpi_1805	4.863e-43	181.0	COG1647@1|root,COG1647@2|Bacteria,2GCT5@200918|Thermotogae	200918|Thermotogae	S	Alpha/beta hydrolase family	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
GDHHQS1_k127_4025811_7	1499967.BAYZ01000057_gene4726	1.791e-76	282.0	COG1082@1|root,COG1082@2|Bacteria,2NRTI@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_4025811_0	335543.Sfum_2376	6.906e-281	872.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,42PUK@68525|delta/epsilon subdivisions,2WIN4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
GDHHQS1_k127_4025811_5	1304874.JAFY01000007_gene2347	1.762e-113	377.0	COG3643@1|root,COG3643@2|Bacteria,3T9TJ@508458|Synergistetes	508458|Synergistetes	E	TIGRFAM glutamate formiminotransferase	ftcD	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
GDHHQS1_k127_4025811_4	1304874.JAFY01000007_gene2348	2.733e-147	481.0	COG1228@1|root,COG1228@2|Bacteria,3T9W4@508458|Synergistetes	508458|Synergistetes	Q	PFAM amidohydrolase	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
GDHHQS1_k127_4025811_12	584708.Apau_1445	1.181e-42	165.0	COG3404@1|root,COG3404@2|Bacteria,3TB0V@508458|Synergistetes	508458|Synergistetes	E	PFAM Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
GDHHQS1_k127_4025811_1	335543.Sfum_2378	4.727e-206	664.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
GDHHQS1_k127_4025811_15	290317.Cpha266_1382	1.082e-09	70.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
GDHHQS1_k127_4025811_14	216591.BCAL2555	1.419e-12	70.0	COG2336@1|root,COG2336@2|Bacteria,1NBUD@1224|Proteobacteria,2VWF5@28216|Betaproteobacteria,1KER6@119060|Burkholderiaceae	28216|Betaproteobacteria	T	PFAM SpoVT AbrB	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4025811_10	504728.K649_03170	3.182e-45	179.0	COG2115@1|root,COG2115@2|Bacteria,1WJGE@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Belongs to the xylose isomerase family	xylA	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_4025811_16	1123274.KB899407_gene380	7.664e-07	57.0	COG1051@1|root,COG1051@2|Bacteria,2J968@203691|Spirochaetes	203691|Spirochaetes	F	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
GDHHQS1_k127_4025811_8	1123274.KB899408_gene3925	2.916e-76	273.0	COG4658@1|root,COG4658@2|Bacteria,2J9NA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the NqrB RnfD family	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
GDHHQS1_k127_4057303_0	1499967.BAYZ01000171_gene5559	3.938e-122	396.0	COG0190@1|root,COG0190@2|Bacteria,2NNY1@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
GDHHQS1_k127_4057303_1	118166.JH976538_gene5057	3.202e-110	391.0	COG4191@1|root,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,Response_reg
GDHHQS1_k127_4057303_2	744872.Spica_0319	5.374e-107	376.0	COG2114@1|root,COG2114@2|Bacteria,2J6ME@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
GDHHQS1_k127_4057303_5	935866.JAER01000026_gene3160	1.623e-10	73.0	COG5621@1|root,COG5621@2|Bacteria,2GNHM@201174|Actinobacteria	201174|Actinobacteria	S	secreted hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CrtC
GDHHQS1_k127_4057303_3	390874.Tpet_1483	3.762e-49	180.0	COG1453@1|root,COG1453@2|Bacteria,2GE5P@200918|Thermotogae	200918|Thermotogae	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_4058561_0	243231.GSU1655	1.548e-106	381.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,43T3F@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_4058561_5	96561.Dole_0771	1.131e-19	101.0	COG0484@1|root,COG0484@2|Bacteria,1N40E@1224|Proteobacteria,42UFJ@68525|delta/epsilon subdivisions,2WQAY@28221|Deltaproteobacteria,2MP0M@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4058561_3	1128421.JAGA01000002_gene1814	6.556e-43	162.0	COG0521@1|root,COG0521@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	mog	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0032324,GO:0034641,GO:0042278,GO:0042802,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.75,2.8.1.12,4.99.1.12	ko:K03635,ko:K03831,ko:K09121	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395,R09726	RC00002,RC02507	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1969,iECABU_c1320.ECABU_c00100,iECED1_1282.ECED1_0009,iECNA114_1301.ECNA114_4653,iECP_1309.ECP_0010,iECS88_1305.ECS88_0010,iECSF_1327.ECSF_0009,iECUMN_1333.ECUMN_0010,iEcSMS35_1347.EcSMS35_0008,iLF82_1304.LF82_1379,iNRG857_1313.NRG857_00050,iUMN146_1321.UM146_22820	MoCF_biosynth
GDHHQS1_k127_4058561_2	1121324.CLIT_10c01530	1.859e-46	174.0	COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,25RK7@186804|Peptostreptococcaceae	186801|Clostridia	H	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
GDHHQS1_k127_4058561_1	266117.Rxyl_1981	1.351e-50	186.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4CSG6@84995|Rubrobacteria	84995|Rubrobacteria	H	MoaC family	-	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
GDHHQS1_k127_4058561_4	1045858.Bint_1384	5.97e-20	93.0	COG2896@1|root,COG2896@2|Bacteria,2J7IB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
GDHHQS1_k127_409548_4	545695.TREAZ_1217	1.089e-51	196.0	2BZW8@1|root,32R5W@2|Bacteria,2J6GZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_409548_3	889378.Spiaf_1628	1.278e-58	217.0	COG2214@1|root,COG2214@2|Bacteria,2J5G9@203691|Spirochaetes	203691|Spirochaetes	O	DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
GDHHQS1_k127_409548_5	1123274.KB899419_gene1975	1.494e-48	188.0	COG0760@1|root,COG0760@2|Bacteria,2J6I2@203691|Spirochaetes	203691|Spirochaetes	M	peptidylprolyl isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
GDHHQS1_k127_409548_6	1123274.KB899419_gene1976	9.653e-43	160.0	COG0781@1|root,COG0781@2|Bacteria,2J7V3@203691|Spirochaetes	203691|Spirochaetes	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
GDHHQS1_k127_409548_8	526224.Bmur_2060	1.41e-33	134.0	COG1664@1|root,COG1664@2|Bacteria,2J8N1@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
GDHHQS1_k127_409548_2	665571.STHERM_c09880	2.707e-85	295.0	COG0024@1|root,COG0024@2|Bacteria,2J5Z7@203691|Spirochaetes	203691|Spirochaetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
GDHHQS1_k127_409548_1	545694.TREPR_2807	1.416e-86	289.0	COG2236@1|root,COG2236@2|Bacteria,2J5KF@203691|Spirochaetes	203691|Spirochaetes	F	phosphoribosyl transferase	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
GDHHQS1_k127_409548_9	272568.GDI1048	1.983e-05	49.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
GDHHQS1_k127_409548_10	744872.Spica_1135	2.606e-05	52.0	2A6A2@1|root,30V2P@2|Bacteria,2J9DJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_409548_0	545694.TREPR_1730	1.406e-117	401.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
GDHHQS1_k127_4199277_3	906968.Trebr_0801	4.589e-06	56.0	2EJFP@1|root,33D6N@2|Bacteria,2J5TW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
GDHHQS1_k127_4199277_2	744872.Spica_1835	8.838e-24	103.0	COG1773@1|root,COG1773@2|Bacteria,2J8V4@203691|Spirochaetes	203691|Spirochaetes	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
GDHHQS1_k127_4199277_1	665571.STHERM_c02040	8.928e-37	154.0	COG1600@1|root,COG1600@2|Bacteria,2JAKM@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
GDHHQS1_k127_4199277_0	42256.RradSPS_0294	2.495e-54	196.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4CPG5@84995|Rubrobacteria	84995|Rubrobacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
GDHHQS1_k127_4271219_0	665571.STHERM_c01020	3.015e-104	347.0	COG1210@1|root,COG1210@2|Bacteria,2J70S@203691|Spirochaetes	203691|Spirochaetes	M	Nucleotidyl transferase	gtaB	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
GDHHQS1_k127_4271219_1	1123274.KB899407_gene241	6.208e-77	274.0	COG1301@1|root,COG1301@2|Bacteria,2J6P3@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
GDHHQS1_k127_4273484_1	1307761.L21SP2_0826	2.653e-101	336.0	COG1186@1|root,COG1186@2|Bacteria,2J5QR@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
GDHHQS1_k127_4273484_4	1123274.KB899415_gene2526	1.561e-19	96.0	2FK3B@1|root,34BRF@2|Bacteria,2J8AH@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
GDHHQS1_k127_4273484_3	545695.TREAZ_0006	6.408e-23	110.0	COG1729@1|root,COG1729@2|Bacteria,2J6ZY@203691|Spirochaetes	203691|Spirochaetes	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4273484_0	697281.Mahau_1768	5.797e-109	365.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,42EQH@68295|Thermoanaerobacterales	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
GDHHQS1_k127_4273484_2	1380390.JIAT01000009_gene1420	1.116e-44	170.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_4339579_8	1123274.KB899436_gene1289	8.804e-11	64.0	COG1459@1|root,COG1459@2|Bacteria,2J7Y9@203691|Spirochaetes	203691|Spirochaetes	U	Bacterial type II secretion system protein F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
GDHHQS1_k127_4339579_3	906968.Trebr_1318	4.939e-46	170.0	COG2165@1|root,COG2165@2|Bacteria,2J7Y8@203691|Spirochaetes	203691|Spirochaetes	NU	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
GDHHQS1_k127_4339579_7	1123274.KB899436_gene1296	1.734e-31	140.0	2ANKW@1|root,31DK4@2|Bacteria,2JAP9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4339579_1	1395571.TMS3_0116460	2.079e-55	203.0	COG2197@1|root,COG2197@2|Bacteria,1RENN@1224|Proteobacteria,1SYCS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	uhpA	-	-	ko:K07686	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
GDHHQS1_k127_4339579_2	335543.Sfum_1869	7.973e-54	202.0	COG0784@1|root,COG4585@1|root,COG0784@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42U4X@68525|delta/epsilon subdivisions,2WQCD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_9
GDHHQS1_k127_4339579_4	1173027.Mic7113_0261	1.391e-45	169.0	COG0784@1|root,COG0784@2|Bacteria,1G548@1117|Cyanobacteria,1HBA2@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
GDHHQS1_k127_4339579_0	690850.Desaf_3480	7.56e-77	276.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,43D9G@68525|delta/epsilon subdivisions,2WUNM@28221|Deltaproteobacteria,2MHI6@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
GDHHQS1_k127_4339579_5	690850.Desaf_2597	3.517e-44	174.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42UZS@68525|delta/epsilon subdivisions,2X77T@28221|Deltaproteobacteria,2MA9G@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051,ko:K15551	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	NMT1,NMT1_2
GDHHQS1_k127_4339579_10	298386.PBPRB1539	4.965e-07	54.0	COG1414@1|root,COG3276@1|root,COG1414@2|Bacteria,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,1RQJI@1236|Gammaproteobacteria,1XWBW@135623|Vibrionales	135623|Vibrionales	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_3
GDHHQS1_k127_4339579_9	404589.Anae109_0256	3.82e-07	58.0	2DYDA@1|root,34983@2|Bacteria,1N38S@1224|Proteobacteria,4318W@68525|delta/epsilon subdivisions,2WWC4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_4339579_6	298386.PBPRB1539	2.82e-37	150.0	COG1414@1|root,COG3276@1|root,COG1414@2|Bacteria,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,1RQJI@1236|Gammaproteobacteria,1XWBW@135623|Vibrionales	135623|Vibrionales	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_3
GDHHQS1_k127_4371396_1	643648.Slip_0169	1.038e-40	167.0	COG1368@1|root,COG1368@2|Bacteria,1V8EX@1239|Firmicutes,24KF8@186801|Clostridia	186801|Clostridia	M	CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
GDHHQS1_k127_4371396_0	861299.J421_6055	5.31e-114	378.0	COG2242@1|root,COG2242@2|Bacteria	2|Bacteria	H	protein methyltransferase activity	-	-	2.1.1.242,2.1.1.303,2.1.1.319	ko:K11434,ko:K15984,ko:K20421	ko01059,ko01130,ko04068,ko04922,map01059,map01130,map04068,map04922	M00830	R10963,R11216,R11217,R11219	RC00003,RC00392,RC02120,RC03388,RC03390	ko00000,ko00001,ko00002,ko01000,ko03009,ko03036	-	-	-	DOT1,Methyltransf_21,Methyltransf_25
GDHHQS1_k127_4484559_1	1499967.BAYZ01000171_gene5571	1.433e-83	298.0	COG1143@1|root,COG1143@2|Bacteria,2NQ09@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
GDHHQS1_k127_4484559_0	1499967.BAYZ01000171_gene5570	1.644e-109	371.0	COG4656@1|root,COG4656@2|Bacteria	2|Bacteria	C	electron transfer activity	citB	-	-	ko:K03616,ko:K13795	-	-	-	-	ko00000	-	-	-	CCG,Complex1_51K,Fer4,Fer4_17,Fer4_21,Fer4_8,FrhB_FdhB_C
GDHHQS1_k127_4484559_3	1499967.BAYZ01000171_gene5568	1e-68	239.0	COG1908@1|root,COG1908@2|Bacteria,2NPFI@2323|unclassified Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	hdrG	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
GDHHQS1_k127_4484559_2	1499967.BAYZ01000171_gene5567	1.517e-77	265.0	COG1148@1|root,COG4231@1|root,COG1148@2|Bacteria,COG4231@2|Bacteria	2|Bacteria	C	indolepyruvate ferredoxin oxidoreductase activity	bamE	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_20,Fer4_7,Pyr_redox_2
GDHHQS1_k127_4490122_5	1307761.L21SP2_1427	4.723e-27	111.0	COG0119@1|root,COG0119@2|Bacteria,2J6AF@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
GDHHQS1_k127_4490122_3	1089553.Tph_c19820	1.843e-54	207.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,42G3R@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
GDHHQS1_k127_4490122_2	1125863.JAFN01000001_gene2478	1.472e-168	550.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
GDHHQS1_k127_4490122_1	1121428.DESHY_150097___1	1.381e-178	606.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,260GB@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
GDHHQS1_k127_4490122_4	351627.Csac_1143	1.857e-47	175.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,42GAW@68295|Thermoanaerobacterales	186801|Clostridia	E	Acetolactate synthase, small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
GDHHQS1_k127_4490122_0	588581.Cpap_1800	3.338e-232	734.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3WGYC@541000|Ruminococcaceae	186801|Clostridia	H	Thiamine pyrophosphate enzyme, central domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
GDHHQS1_k127_4490122_6	744872.Spica_0016	1.682e-08	57.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
GDHHQS1_k127_4493941_5	1007104.SUS17_1572	4.567e-12	77.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2K08K@204457|Sphingomonadales	204457|Sphingomonadales	NT	CheA signal transduction histidine kinase	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
GDHHQS1_k127_4493941_4	693661.Arcve_1465	1.609e-27	121.0	COG1871@1|root,arCOG02380@2157|Archaea,2XZ1N@28890|Euryarchaeota,2471T@183980|Archaeoglobi	183980|Archaeoglobi	N	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
GDHHQS1_k127_4493941_2	1500894.JQNN01000001_gene1972	5.261e-52	201.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VKFS@28216|Betaproteobacteria,4726S@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
GDHHQS1_k127_4493941_0	62928.azo0402	9.212e-79	288.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2VI13@28216|Betaproteobacteria,2KVEM@206389|Rhodocyclales	206389|Rhodocyclales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
GDHHQS1_k127_4493941_6	744872.Spica_1423	3.216e-07	61.0	2AMU2@1|root,31CQK@2|Bacteria,2J8GC@203691|Spirochaetes	203691|Spirochaetes	S	Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
GDHHQS1_k127_4493941_1	204669.Acid345_2498	5.616e-60	220.0	COG3437@1|root,COG3437@2|Bacteria,3Y2TI@57723|Acidobacteria,2JHKC@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
GDHHQS1_k127_4493941_3	1121448.DGI_1665	2.629e-43	171.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,42T5Y@68525|delta/epsilon subdivisions,2WNT6@28221|Deltaproteobacteria,2MAZR@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
GDHHQS1_k127_4568934_0	589865.DaAHT2_0901	4.81e-297	932.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
GDHHQS1_k127_4568934_1	1304888.ATWF01000001_gene659	1.162e-136	445.0	COG0505@1|root,COG0505@2|Bacteria,2GF07@200930|Deferribacteres	200930|Deferribacteres	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
GDHHQS1_k127_4568934_2	404380.Gbem_3571	3.379e-50	186.0	COG4832@1|root,COG4832@2|Bacteria,1RBGY@1224|Proteobacteria	1224|Proteobacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
GDHHQS1_k127_4577872_7	1158292.JPOE01000002_gene2965	7.925e-06	53.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2VQ09@28216|Betaproteobacteria,1KITD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
GDHHQS1_k127_4577872_0	180332.JTGN01000003_gene1963	3.188e-140	462.0	COG1070@1|root,COG1070@2|Bacteria,1V3CR@1239|Firmicutes,25CBB@186801|Clostridia	186801|Clostridia	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_4577872_2	1120950.KB892794_gene2342	3.181e-83	295.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria,4DQ3J@85009|Propionibacteriales	201174|Actinobacteria	V	Beta-lactamase	ampC2	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
GDHHQS1_k127_4577872_8	1449355.JQNR01000005_gene5653	0.0002178	55.0	COG3345@1|root,COG3345@2|Bacteria,2GJJ1@201174|Actinobacteria	201174|Actinobacteria	G	alpha-galactosidase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
GDHHQS1_k127_4577872_4	1121904.ARBP01000003_gene6217	1.372e-35	139.0	COG1725@1|root,COG1725@2|Bacteria,4NT1X@976|Bacteroidetes,47QCP@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR
GDHHQS1_k127_4577872_6	1124780.ANNU01000048_gene2114	2.572e-06	58.0	2DPSV@1|root,3338R@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4577872_1	1121904.ARBP01000003_gene6219	1.363e-92	312.0	COG1131@1|root,COG1131@2|Bacteria,4NFRV@976|Bacteroidetes,47N9E@768503|Cytophagia	976|Bacteroidetes	V	ABC-type multidrug transport system ATPase component	cbiO	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_4577872_3	485913.Krac_0538	1.033e-62	229.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
GDHHQS1_k127_4577872_5	494419.ALPM01000024_gene260	1.215e-10	68.0	COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria,1W9H8@1268|Micrococcaceae	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
GDHHQS1_k127_4591839_2	215803.DB30_5064	5.15e-95	346.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1Q712@1224|Proteobacteria,433SV@68525|delta/epsilon subdivisions,2WYAY@28221|Deltaproteobacteria,2YXT0@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
GDHHQS1_k127_4591839_6	697281.Mahau_0126	0.0001977	54.0	COG1653@1|root,COG1653@2|Bacteria,1TRF2@1239|Firmicutes,25CTC@186801|Clostridia,42EKC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_4591839_5	485913.Krac_2635	5.887e-33	146.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
GDHHQS1_k127_4591839_3	1303518.CCALI_00292	5.69e-51	202.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	DUF5128,NHL,VPEP
GDHHQS1_k127_4591839_0	706587.Desti_5611	3.582e-138	451.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2MQ8M@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.11,4.4.1.8	ko:K01739,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
GDHHQS1_k127_4591839_1	1499967.BAYZ01000104_gene3694	2.761e-105	347.0	COG1028@1|root,COG1028@2|Bacteria	1499967.BAYZ01000104_gene3694|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4591839_4	1121423.JONT01000009_gene1501	8.945e-34	137.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24GQP@186801|Clostridia,266UQ@186807|Peptococcaceae	186801|Clostridia	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_461204_4	871968.DESME_15655	3.027e-52	194.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,26173@186807|Peptococcaceae	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
GDHHQS1_k127_461204_0	1236514.BAKL01000099_gene5180	1.384e-153	499.0	COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,2FNAR@200643|Bacteroidia,4AKUS@815|Bacteroidaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 20, catalytic domain protein	nagZ2	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b
GDHHQS1_k127_461204_6	1033732.CAHI01000030_gene1006	2.718e-09	71.0	COG0366@1|root,COG0366@2|Bacteria,4P0R0@976|Bacteroidetes	976|Bacteroidetes	G	Alpha amylase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_461204_1	448385.sce6750	3.931e-146	471.0	COG4586@1|root,COG4586@2|Bacteria,1RA7G@1224|Proteobacteria,42RT3@68525|delta/epsilon subdivisions,2WNGM@28221|Deltaproteobacteria,2YU3C@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_461204_3	272134.KB731324_gene3159	6.544e-66	259.0	COG4587@1|root,COG4587@2|Bacteria	2|Bacteria	S	transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
GDHHQS1_k127_461204_2	794903.OPIT5_16000	1.157e-83	294.0	COG3694@1|root,COG3694@2|Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
GDHHQS1_k127_461204_5	1007103.AFHW01000114_gene3786	2.465e-33	132.0	COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,4HBB0@91061|Bacilli,26QHF@186822|Paenibacillaceae	91061|Bacilli	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_4653309_5	744872.Spica_0637	9.44e-60	215.0	COG1653@1|root,COG1653@2|Bacteria,2J66Q@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_4653309_3	518766.Rmar_2470	2.217e-80	282.0	COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes	976|Bacteroidetes	V	Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
GDHHQS1_k127_4653309_7	316067.Geob_2072	1.123e-34	144.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
GDHHQS1_k127_4653309_4	765420.OSCT_0273	8.92e-80	282.0	COG0451@1|root,COG0451@2|Bacteria,2GAZF@200795|Chloroflexi,374ZI@32061|Chloroflexia	32061|Chloroflexia	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	3Beta_HSD
GDHHQS1_k127_4653309_8	324925.Ppha_1113	7.907e-08	61.0	2ESXY@1|root,33KG8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4653309_1	1173028.ANKO01000127_gene4126	1.398e-105	362.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1G2RJ@1117|Cyanobacteria,1H9PS@1150|Oscillatoriales	1117|Cyanobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HATPase_c,HisKA,PAS_4,Response_reg
GDHHQS1_k127_4653309_0	1382356.JQMP01000004_gene447	5.423e-203	642.0	COG4948@1|root,COG4948@2|Bacteria,2G69R@200795|Chloroflexi,27YWW@189775|Thermomicrobia	189775|Thermomicrobia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS1_k127_4653309_6	658086.HMPREF0994_01771	6.01e-49	191.0	COG5012@1|root,COG5012@2|Bacteria,1V82H@1239|Firmicutes,24HQC@186801|Clostridia	186801|Clostridia	S	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4653309_2	926550.CLDAP_29120	9.85e-97	318.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_4711893_0	1191523.MROS_1835	0.0	1235.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
GDHHQS1_k127_4711893_1	665571.STHERM_c12280	2.525e-61	233.0	COG0738@1|root,COG0738@2|Bacteria,2J7KW@203691|Spirochaetes	203691|Spirochaetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_4711893_2	933262.AXAM01000034_gene1574	6.22e-49	198.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42RPD@68525|delta/epsilon subdivisions,2WNI0@28221|Deltaproteobacteria,2MK1B@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
GDHHQS1_k127_4864404_0	552811.Dehly_0563	4.649e-163	523.0	COG0426@1|root,COG0426@2|Bacteria,2G9HN@200795|Chloroflexi	200795|Chloroflexi	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4864404_2	1536775.H70737_00930	4.871e-84	295.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,4HAAW@91061|Bacilli,26T2A@186822|Paenibacillaceae	91061|Bacilli	S	Family of unknown function (DUF438)	XK27_04775	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
GDHHQS1_k127_4864404_5	158190.SpiGrapes_1174	1.182e-74	276.0	COG1122@1|root,COG1122@2|Bacteria,2J5SA@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
GDHHQS1_k127_4864404_9	158190.SpiGrapes_1173	1.516e-24	121.0	COG0619@1|root,COG0619@2|Bacteria,2J7RZ@203691|Spirochaetes	203691|Spirochaetes	P	cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
GDHHQS1_k127_4864404_8	158190.SpiGrapes_1172	1.851e-38	150.0	COG4720@1|root,COG4720@2|Bacteria	2|Bacteria	P	Psort location CytoplasmicMembrane, score	XK27_01265	-	-	ko:K16923,ko:K16924	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28,3.A.1.29	-	-	ECF-ribofla_trS
GDHHQS1_k127_4864404_6	1123274.KB899419_gene1943	2.209e-47	186.0	COG0325@1|root,COG0325@2|Bacteria,2J71S@203691|Spirochaetes	203691|Spirochaetes	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
GDHHQS1_k127_4864404_11	744872.Spica_1584	2.101e-13	79.0	290S3@1|root,34CB1@2|Bacteria,2J8EJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4864404_3	545694.TREPR_3488	2.738e-80	278.0	COG0564@1|root,COG0564@2|Bacteria,2J63B@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil	rluD_1	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
GDHHQS1_k127_4864404_7	158190.SpiGrapes_0332	1.105e-40	168.0	COG0491@1|root,COG0491@2|Bacteria,2J7B4@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS1_k127_4864404_12	257310.BB0795	7.628e-07	57.0	COG1357@1|root,COG5351@1|root,COG1357@2|Bacteria,COG5351@2|Bacteria,1N7U9@1224|Proteobacteria,2VNN1@28216|Betaproteobacteria,3T1CG@506|Alcaligenaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2169)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2169,Pentapeptide,Pentapeptide_4
GDHHQS1_k127_4864404_10	1124982.MSI_13700	4.666e-20	102.0	2EH48@1|root,33AW7@2|Bacteria,2J921@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_4864404_4	1539298.JO41_04920	1.066e-79	278.0	COG1162@1|root,COG1162@2|Bacteria,2J5AI@203691|Spirochaetes	203691|Spirochaetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
GDHHQS1_k127_4864404_1	243275.TDE_1450	1.519e-150	505.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
GDHHQS1_k127_5008021_1	1487923.DP73_14320	1.729e-77	273.0	COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia,263B9@186807|Peptococcaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
GDHHQS1_k127_5008021_0	1123274.KB899411_gene3031	9.412e-177	562.0	COG0017@1|root,COG0017@2|Bacteria,2J73H@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
GDHHQS1_k127_5008021_2	290397.Adeh_0486	5.137e-62	231.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1Q712@1224|Proteobacteria,433SV@68525|delta/epsilon subdivisions,2WYAY@28221|Deltaproteobacteria,2YXT0@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
GDHHQS1_k127_5096905_2	1459636.NTE_01726	1.244e-101	355.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
GDHHQS1_k127_5096905_3	886293.Sinac_6174	9.271e-84	289.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
GDHHQS1_k127_5096905_0	1211813.CAPH01000009_gene257	1.189e-131	449.0	COG3345@1|root,COG3345@2|Bacteria,4NZUR@976|Bacteroidetes,2FNUD@200643|Bacteroidia	976|Bacteroidetes	G	Melibiase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
GDHHQS1_k127_5096905_1	926569.ANT_05540	5.236e-112	370.0	COG1363@1|root,COG1363@2|Bacteria,2G6EE@200795|Chloroflexi	200795|Chloroflexi	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
GDHHQS1_k127_5135677_10	1499967.BAYZ01000068_gene1973	4.994e-08	64.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27,2.7.7.91	ko:K00975,ko:K20427	ko00500,ko00520,ko00525,ko01100,ko01110,ko01130,ko02026,map00500,map00520,map00525,map01100,map01110,map01130,map02026	M00565,M00814	R00948,R11237,R11246,R11402	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
GDHHQS1_k127_5135677_7	573413.Spirs_2421	2.575e-45	182.0	COG2304@1|root,COG2304@2|Bacteria,2J712@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
GDHHQS1_k127_5135677_1	573413.Spirs_2420	9.333e-313	971.0	2EZDZ@1|root,33SJ6@2|Bacteria,2J6M2@203691|Spirochaetes	203691|Spirochaetes	S	Cytoplasmic filament protein A	cfpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5135677_5	1123274.KB899419_gene1996	4.006e-95	323.0	2F0EQ@1|root,33THS@2|Bacteria,2J5ZQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5135677_0	573413.Spirs_2418	0.0	1086.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J6C2@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C
GDHHQS1_k127_5135677_6	744872.Spica_1146	4.508e-74	273.0	COG0457@1|root,COG0457@2|Bacteria,2J58A@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
GDHHQS1_k127_5135677_8	535289.Dtpsy_1888	2.492e-20	105.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VITJ@28216|Betaproteobacteria,4AA3T@80864|Comamonadaceae	28216|Betaproteobacteria	NT	chemotaxis	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal,sCache_2
GDHHQS1_k127_5135677_3	1123274.KB899424_gene3019	9.558e-171	556.0	COG0015@1|root,COG0015@2|Bacteria,2J60J@203691|Spirochaetes	203691|Spirochaetes	F	Adenylosuccinate lyase	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
GDHHQS1_k127_5135677_4	489825.LYNGBM3L_69090	7.675e-124	413.0	COG0104@1|root,COG0104@2|Bacteria,1G147@1117|Cyanobacteria,1H831@1150|Oscillatoriales	1117|Cyanobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
GDHHQS1_k127_5135677_2	665571.STHERM_c10030	3.848e-208	674.0	COG0519@1|root,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
GDHHQS1_k127_5135677_9	545695.TREAZ_0574	6.317e-09	64.0	28YH3@1|root,2ZKB9@2|Bacteria,2J8G8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5208329_0	1120954.ATXE01000004_gene88	7.88e-75	275.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,DUF3459
GDHHQS1_k127_522512_1	555088.DealDRAFT_2606	8.639e-100	349.0	COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,42JP1@68298|Syntrophomonadaceae	186801|Clostridia	T	CheA signal transduction histidine	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
GDHHQS1_k127_522512_5	521460.Athe_2134	8.579e-15	85.0	COG1406@1|root,COG1406@2|Bacteria,1V6JI@1239|Firmicutes,25DXQ@186801|Clostridia,42H88@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM CheC domain protein	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
GDHHQS1_k127_522512_2	1120972.AUMH01000011_gene207	7.344e-42	156.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli,279U5@186823|Alicyclobacillaceae	91061|Bacilli	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
GDHHQS1_k127_522512_4	748247.AZKH_0042	5.331e-27	115.0	COG0784@1|root,COG0784@2|Bacteria,1QU3I@1224|Proteobacteria,2WGTG@28216|Betaproteobacteria	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
GDHHQS1_k127_522512_0	1125863.JAFN01000001_gene2253	1.272e-119	399.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_522512_3	768706.Desor_4001	1.63e-34	143.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261ZQ@186807|Peptococcaceae	186801|Clostridia	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
GDHHQS1_k127_5289649_2	1173028.ANKO01000044_gene791	6.209e-16	81.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,FR47,GNAT_acetyltran
GDHHQS1_k127_5289649_1	1304284.L21TH_0785	9.546e-45	176.0	COG5522@1|root,COG5522@2|Bacteria,1V4XE@1239|Firmicutes,24Q8V@186801|Clostridia,36KVT@31979|Clostridiaceae	186801|Clostridia	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
GDHHQS1_k127_5289649_0	861299.J421_2962	1.019e-104	370.0	COG4191@1|root,COG4191@2|Bacteria,1ZUC5@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
GDHHQS1_k127_5320386_11	1123274.KB899431_gene3247	7.11e-13	72.0	COG2103@1|root,COG2103@2|Bacteria	2|Bacteria	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	-
GDHHQS1_k127_5320386_9	1122925.KB895400_gene115	9.743e-45	173.0	COG0454@1|root,COG0456@2|Bacteria,1VCET@1239|Firmicutes,4HDB3@91061|Bacilli,26VZ3@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS1_k127_5320386_5	1122915.AUGY01000074_gene4353	5.036e-77	278.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26RMX@186822|Paenibacillaceae	91061|Bacilli	G	Glycoside hydrolase family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
GDHHQS1_k127_5320386_4	292459.STH303	1.144e-95	342.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,24CF8@186801|Clostridia	186801|Clostridia	F	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF1343
GDHHQS1_k127_5320386_7	665956.HMPREF1032_00514	3.708e-64	247.0	COG2377@1|root,COG2377@2|Bacteria,1TSBU@1239|Firmicutes,247S1@186801|Clostridia	186801|Clostridia	O	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
GDHHQS1_k127_5320386_2	158190.SpiGrapes_0946	3.775e-113	396.0	COG0395@1|root,COG0395@2|Bacteria,2J6NP@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_5320386_1	357809.Cphy_1119	1.05e-148	476.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,248XU@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_5320386_0	158189.SpiBuddy_1013	3.037e-254	794.0	COG1653@1|root,COG1653@2|Bacteria,2J728@203691|Spirochaetes	203691|Spirochaetes	G	bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
GDHHQS1_k127_5320386_8	1541065.JRFE01000014_gene1151	1.21e-60	237.0	COG3420@1|root,COG3420@2|Bacteria,1GPUW@1117|Cyanobacteria,3VJI4@52604|Pleurocapsales	1117|Cyanobacteria	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
GDHHQS1_k127_5320386_10	306281.AJLK01000170_gene5036	1.281e-20	108.0	COG2202@1|root,COG2202@2|Bacteria	2|Bacteria	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_5320386_6	1123508.JH636439_gene1315	4.802e-67	259.0	COG4191@1|root,COG4191@2|Bacteria,2J2PC@203682|Planctomycetes	203682|Planctomycetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
GDHHQS1_k127_5320386_3	565033.GACE_1704	2.305e-110	374.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,245UV@183980|Archaeoglobi	183980|Archaeoglobi	C	Glycolate oxidase subunit (GlcD)	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0036094,GO:0043167,GO:0043168,GO:0047809,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.1.3.15,1.1.99.6	ko:K00104,ko:K21836	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
GDHHQS1_k127_5320386_12	1123226.KB899278_gene630	0.0002033	46.0	COG1234@1|root,COG1234@2|Bacteria,1UYM3@1239|Firmicutes,4HEWE@91061|Bacilli,26U57@186822|Paenibacillaceae	91061|Bacilli	S	beta-lactamase	rnaZ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
GDHHQS1_k127_533955_2	278957.ABEA03000060_gene3064	9.292e-67	240.0	COG0421@1|root,COG0421@2|Bacteria,46Z5G@74201|Verrucomicrobia,3K91M@414999|Opitutae	414999|Opitutae	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_533955_3	1499684.CCNP01000025_gene3587	1.115e-45	177.0	2EXW2@1|root,33R56@2|Bacteria,1VR16@1239|Firmicutes,24IMV@186801|Clostridia,36RIZ@31979|Clostridiaceae	186801|Clostridia	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
GDHHQS1_k127_533955_5	867845.KI911784_gene1816	4.072e-19	102.0	COG0296@1|root,COG0296@2|Bacteria,2G9SJ@200795|Chloroflexi,377QN@32061|Chloroflexia	32061|Chloroflexia	G	PFAM glycoside hydrolase family 13 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
GDHHQS1_k127_533955_0	452637.Oter_4352	1.881e-224	714.0	COG4868@1|root,COG4868@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1846)	XK27_07020	-	-	-	-	-	-	-	-	-	-	-	DUF1846
GDHHQS1_k127_533955_1	665571.STHERM_c01070	1.889e-155	508.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
GDHHQS1_k127_533955_4	665571.STHERM_c01120	2.606e-44	187.0	2C0A1@1|root,33WBM@2|Bacteria,2J8WC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5349537_2	1123368.AUIS01000004_gene120	5.907e-81	295.0	COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria,2NDJ6@225057|Acidithiobacillales	1236|Gammaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd
GDHHQS1_k127_5349537_5	511051.CSE_10050	7.03e-16	88.0	2BVWN@1|root,33U5I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5349537_3	926569.ANT_24650	7.789e-19	100.0	COG1541@1|root,COG1541@2|Bacteria,2G5RU@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
GDHHQS1_k127_5349537_1	1307761.L21SP2_1482	1.167e-93	317.0	COG3221@1|root,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
GDHHQS1_k127_5349537_0	1307761.L21SP2_1483	2.591e-104	361.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
GDHHQS1_k127_5349537_4	1307761.L21SP2_1484	3.264e-16	90.0	COG3639@1|root,COG3639@2|Bacteria,2J6TW@203691|Spirochaetes	203691|Spirochaetes	U	ABC transporter (Permease)	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
GDHHQS1_k127_5425322_4	1437824.BN940_13166	5.467e-16	83.0	COG2388@1|root,COG2388@2|Bacteria,1N8AQ@1224|Proteobacteria,2VW02@28216|Betaproteobacteria,3T4TK@506|Alcaligenaceae	28216|Betaproteobacteria	S	Acetyltransferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
GDHHQS1_k127_5425322_3	351160.RCIX417	6.483e-42	167.0	arCOG04380@1|root,arCOG04380@2157|Archaea,2Y4IJ@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5425322_2	670487.Ocepr_0357	3.574e-47	175.0	COG0517@1|root,COG0517@2|Bacteria,1WNHR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG2905 signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
GDHHQS1_k127_5425322_1	545695.TREAZ_0852	9.745e-55	210.0	2DM20@1|root,31DN4@2|Bacteria,2J5AS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5425322_0	316067.Geob_0371	1.34e-141	461.0	COG4277@1|root,COG4277@2|Bacteria,1MVCV@1224|Proteobacteria,42NNA@68525|delta/epsilon subdivisions,2WTR9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
GDHHQS1_k127_5437434_6	1499967.BAYZ01000014_gene6411	1.323e-78	273.0	COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_5437434_10	1499967.BAYZ01000095_gene4055	5.133e-54	197.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
GDHHQS1_k127_5437434_7	1499967.BAYZ01000095_gene4057	5.444e-74	272.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
GDHHQS1_k127_5437434_0	1121861.KB899916_gene1707	1.343e-183	584.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,2JPK9@204441|Rhodospirillales	204441|Rhodospirillales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
GDHHQS1_k127_5437434_8	1111454.HMPREF1250_0799	9.652e-59	225.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,4H2G0@909932|Negativicutes	909932|Negativicutes	S	Flavoprotein family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
GDHHQS1_k127_5437434_3	1128421.JAGA01000003_gene3269	4.861e-107	364.0	COG2262@1|root,COG2262@2|Bacteria,2NNWI@2323|unclassified Bacteria	2|Bacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
GDHHQS1_k127_5437434_9	1278308.KB907075_gene1266	1.293e-57	211.0	COG0730@1|root,COG0730@2|Bacteria,2GK5W@201174|Actinobacteria,4FM95@85023|Microbacteriaceae	201174|Actinobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
GDHHQS1_k127_5437434_14	525898.Sdel_0655	2.21e-23	117.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42USK@68525|delta/epsilon subdivisions,2YPZR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
GDHHQS1_k127_5437434_11	563192.HMPREF0179_01009	9.991e-44	166.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42T6B@68525|delta/epsilon subdivisions,2WPVS@28221|Deltaproteobacteria,2MGG2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Aminoacyl-tRNA editing domain	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
GDHHQS1_k127_5437434_12	1499967.BAYZ01000167_gene6735	2.493e-34	149.0	COG0454@1|root,COG0456@2|Bacteria,2NS1J@2323|unclassified Bacteria	2|Bacteria	K	FR47-like protein	argO	-	2.3.1.1	ko:K03826,ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
GDHHQS1_k127_5437434_5	660470.Theba_2271	3.128e-82	311.0	COG0535@1|root,COG0535@2|Bacteria,2GE4B@200918|Thermotogae	200918|Thermotogae	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
GDHHQS1_k127_5437434_4	443144.GM21_1870	1.189e-87	328.0	COG2984@1|root,COG4191@1|root,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,43TUP@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3,sCache_2
GDHHQS1_k127_5437434_1	1191523.MROS_2212	4.029e-159	519.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_5437434_16	929713.NIASO_17705	1.139e-16	92.0	COG4667@1|root,COG4667@2|Bacteria,4NF0K@976|Bacteroidetes	976|Bacteroidetes	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
GDHHQS1_k127_5437434_2	1499967.BAYZ01000182_gene4442	1.858e-126	413.0	COG0673@1|root,COG0673@2|Bacteria,2NQJN@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_5437434_13	1499967.BAYZ01000117_gene3303	1.146e-25	109.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_5437546_1	889378.Spiaf_1749	2.138e-67	235.0	COG2334@1|root,COG2334@2|Bacteria,2J9JA@203691|Spirochaetes	203691|Spirochaetes	S	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
GDHHQS1_k127_5437546_0	448385.sce7663	2.281e-190	609.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
GDHHQS1_k127_5437546_2	1499967.BAYZ01000103_gene3728	2.932e-39	148.0	COG2350@1|root,COG2350@2|Bacteria,2NR74@2323|unclassified Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
GDHHQS1_k127_5437546_3	999541.bgla_1g21730	1.866e-37	151.0	arCOG09511@1|root,2Z9DH@2|Bacteria,1MXRV@1224|Proteobacteria,2VYEG@28216|Betaproteobacteria,1K1KC@119060|Burkholderiaceae	28216|Betaproteobacteria	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
GDHHQS1_k127_5447956_4	909663.KI867150_gene970	5.202e-29	131.0	COG4191@1|root,COG4191@2|Bacteria,1R89N@1224|Proteobacteria,42QDX@68525|delta/epsilon subdivisions,2WKNA@28221|Deltaproteobacteria,2MR83@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
GDHHQS1_k127_5447956_2	1480694.DC28_02930	6.581e-74	267.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	natB	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
GDHHQS1_k127_5447956_1	1480694.DC28_02925	2.937e-104	346.0	COG4152@1|root,COG4152@2|Bacteria,2JBF0@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS1_k127_5447956_0	331869.BAL199_24904	2.245e-137	451.0	COG0673@1|root,COG0673@2|Bacteria,1NVJK@1224|Proteobacteria,2U0NE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_5447956_3	1499967.BAYZ01000182_gene4469	4.255e-66	230.0	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
GDHHQS1_k127_5462071_1	1173028.ANKO01000035_gene3718	1.475e-29	138.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1H968@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8,Trypsin_2
GDHHQS1_k127_5462071_0	926550.CLDAP_12830	3.616e-88	301.0	COG3669@1|root,COG3669@2|Bacteria,2G69T@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase family 29 (alpha-L-fucosidase)	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
GDHHQS1_k127_5466272_13	665571.STHERM_c16630	2.763e-54	192.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
GDHHQS1_k127_5466272_3	313628.LNTAR_18720	8.597e-119	417.0	COG1915@1|root,COG1915@2|Bacteria	2|Bacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5466272_1	1434325.AZQN01000006_gene3304	1.725e-155	513.0	COG0546@1|root,COG2870@1|root,COG0546@2|Bacteria,COG2870@2|Bacteria,4NJ8F@976|Bacteroidetes,47MRA@768503|Cytophagia	976|Bacteroidetes	M	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,PfkB
GDHHQS1_k127_5466272_7	545695.TREAZ_2084	1.044e-82	285.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026,ko:K17317	ko02010,map02010	M00207,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.24,3.A.1.1.30	-	-	BPD_transp_1
GDHHQS1_k127_5466272_6	545695.TREAZ_2083	6.867e-90	305.0	COG1175@1|root,COG1175@2|Bacteria,2J5SW@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_5466272_4	177437.HRM2_25740	6.944e-116	388.0	COG1653@1|root,COG1653@2|Bacteria,1N98V@1224|Proteobacteria	1224|Proteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
GDHHQS1_k127_5466272_8	1499967.BAYZ01000117_gene3307	3.426e-81	282.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
GDHHQS1_k127_5466272_2	278957.ABEA03000005_gene4380	2.401e-148	481.0	COG0407@1|root,COG0407@2|Bacteria,46WW7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_5466272_0	1303518.CCALI_01759	1.145e-155	516.0	COG0383@1|root,COG0383@2|Bacteria	2|Bacteria	G	mannose metabolic process	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
GDHHQS1_k127_5466272_10	1168034.FH5T_11665	5.708e-79	280.0	COG5505@1|root,COG5505@2|Bacteria,4NPE1@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
GDHHQS1_k127_5466272_12	1033810.HLPCO_002490	8.119e-55	201.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
GDHHQS1_k127_5466272_9	742741.HMPREF9475_00026	2.57e-79	284.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,221VW@1506553|Lachnoclostridium	186801|Clostridia	H	FGGY family of carbohydrate kinases, C-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_5466272_5	1304880.JAGB01000001_gene972	2.157e-110	371.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia	186801|Clostridia	C	binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
GDHHQS1_k127_5466272_11	1173028.ANKO01000116_gene5719	7.432e-59	208.0	COG2114@1|root,COG2114@2|Bacteria,1G6D6@1117|Cyanobacteria,1HB2S@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
GDHHQS1_k127_5478870_4	665571.STHERM_c09800	2.713e-84	293.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
GDHHQS1_k127_5478870_5	545695.TREAZ_3664	6.316e-82	299.0	COG0457@1|root,COG0457@2|Bacteria,2J5SR@203691|Spirochaetes	203691|Spirochaetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_6,TPR_8
GDHHQS1_k127_5478870_7	545695.TREAZ_3662	2.523e-25	114.0	COG0319@1|root,COG0319@2|Bacteria,2J7YN@203691|Spirochaetes	203691|Spirochaetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
GDHHQS1_k127_5478870_1	744872.Spica_1228	1.402e-142	481.0	COG1480@1|root,COG1480@2|Bacteria,2J5K4@203691|Spirochaetes	203691|Spirochaetes	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
GDHHQS1_k127_5478870_3	573413.Spirs_2450	1.031e-109	364.0	COG1702@1|root,COG1702@2|Bacteria,2J64H@203691|Spirochaetes	203691|Spirochaetes	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
GDHHQS1_k127_5478870_2	665571.STHERM_c11980	2.489e-117	418.0	COG1452@1|root,COG1452@2|Bacteria,2J5EC@203691|Spirochaetes	203691|Spirochaetes	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5478870_0	573413.Spirs_2452	0.0	1319.0	COG0178@1|root,COG0178@2|Bacteria,2J5BN@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
GDHHQS1_k127_5478870_6	545695.TREAZ_1000	1.057e-26	110.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
GDHHQS1_k127_5487484_1	1449126.JQKL01000003_gene1825	1.483e-93	323.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AFOR_C,AFOR_N
GDHHQS1_k127_5487484_3	1122939.ATUD01000001_gene377	5.1e-05	54.0	COG0314@1|root,COG0315@1|root,COG0521@1|root,COG0314@2|Bacteria,COG0315@2|Bacteria,COG0521@2|Bacteria,2IHR6@201174|Actinobacteria,4CU2W@84995|Rubrobacteria	84995|Rubrobacteria	H	MoaE protein	-	-	-	-	-	-	-	-	-	-	-	-	MoaC,MoaE,ThiS
GDHHQS1_k127_5487484_0	1218074.BAXZ01000013_gene2930	1.264e-117	391.0	COG0169@1|root,COG0169@2|Bacteria,1QNXY@1224|Proteobacteria,2VZFK@28216|Betaproteobacteria,1K5JT@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5487484_2	1122917.KB899663_gene2684	1.787e-36	156.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,4HDT9@91061|Bacilli,26T41@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	-	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
GDHHQS1_k127_550267_13	697281.Mahau_2714	5.3e-25	119.0	28IUJ@1|root,2Z8T8@2|Bacteria,1W5W7@1239|Firmicutes,25E72@186801|Clostridia,42G4J@68295|Thermoanaerobacterales	186801|Clostridia	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
GDHHQS1_k127_550267_6	857293.CAAU_1183	8.62e-85	287.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,36DUF@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_550267_10	234267.Acid_3923	1.018e-38	164.0	COG1073@1|root,COG1073@2|Bacteria,3Y93F@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	-
GDHHQS1_k127_550267_17	743299.Acife_2767	1.213e-07	62.0	COG1872@1|root,COG1872@2|Bacteria,1NGWG@1224|Proteobacteria,1SY5J@1236|Gammaproteobacteria,2NDAJ@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
GDHHQS1_k127_550267_18	1172180.KB911776_gene917	2.889e-07	54.0	2EM92@1|root,33EY7@2|Bacteria,2GS4K@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_550267_15	1121920.AUAU01000010_gene54	2.478e-13	73.0	COG4877@1|root,COG4877@2|Bacteria,3Y8ZI@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_550267_4	745411.B3C1_13254	6.461e-95	321.0	COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,1RUQU@1236|Gammaproteobacteria,1J7WG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0330 Membrane protease subunits, stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
GDHHQS1_k127_550267_3	518766.Rmar_1295	7.182e-99	331.0	COG0428@1|root,COG0428@2|Bacteria,4NGQ8@976|Bacteroidetes,1FJI0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	ZIP Zinc transporter	gufA	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
GDHHQS1_k127_550267_12	546414.Deide_03150	2.33e-36	152.0	COG0697@1|root,COG0697@2|Bacteria,1WJTG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS1_k127_550267_0	1123274.KB899429_gene2872	4.149e-289	897.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
GDHHQS1_k127_550267_16	761193.Runsl_2088	3.095e-08	66.0	COG1983@1|root,COG1983@2|Bacteria,4NS0M@976|Bacteroidetes,47QMV@768503|Cytophagia	976|Bacteroidetes	KT	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
GDHHQS1_k127_550267_5	906968.Trebr_1393	3.957e-86	310.0	COG0820@1|root,COG0820@2|Bacteria,2J5C3@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
GDHHQS1_k127_550267_2	744872.Spica_1434	1.101e-138	450.0	COG0457@1|root,COG0457@2|Bacteria,2J5I5@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
GDHHQS1_k127_550267_14	1307761.L21SP2_1039	7.456e-19	90.0	291RI@1|root,2ZPBI@2|Bacteria,2J8IP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_550267_8	665571.STHERM_c08030	4.232e-59	211.0	COG0131@1|root,COG0131@2|Bacteria,2J6ZQ@203691|Spirochaetes	203691|Spirochaetes	E	imidazoleglycerol-phosphate dehydratase	hisB	-	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_like,IGPD
GDHHQS1_k127_550267_1	1123274.KB899424_gene2975	5.57e-287	891.0	COG0464@1|root,COG0464@2|Bacteria,2J66D@203691|Spirochaetes	203691|Spirochaetes	O	ATPase (AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA
GDHHQS1_k127_550267_7	665571.STHERM_c19320	2.284e-74	265.0	COG0577@1|root,COG0577@2|Bacteria,2J66A@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GDHHQS1_k127_550267_9	246194.CHY_2239	5.131e-42	158.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,42FHC@68295|Thermoanaerobacterales	186801|Clostridia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GDHHQS1_k127_5552724_9	889378.Spiaf_0222	9.921e-19	88.0	2DFDU@1|root,2ZRHI@2|Bacteria,2J8SZ@203691|Spirochaetes	203691|Spirochaetes	S	factor, FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
GDHHQS1_k127_5552724_3	744872.Spica_0014	1.655e-77	274.0	COG1454@1|root,COG1454@2|Bacteria,2J5ZT@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	eutG	-	1.1.1.1	ko:K13954,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
GDHHQS1_k127_5552724_7	665571.STHERM_c01630	4.913e-46	187.0	COG0566@1|root,COG0566@2|Bacteria,2J6AD@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
GDHHQS1_k127_5552724_2	545695.TREAZ_1653	1.292e-100	346.0	COG0407@1|root,COG0407@2|Bacteria,2JAFK@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_5552724_8	665571.STHERM_c01650	6.38e-31	124.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	nrdH	-	-	ko:K03676,ko:K06191	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
GDHHQS1_k127_5552724_1	1123274.KB899407_gene185	7.952e-194	616.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
GDHHQS1_k127_5552724_10	1209989.TepiRe1_2355	1.766e-17	90.0	COG2119@1|root,COG2119@2|Bacteria,1UR7U@1239|Firmicutes,24QEI@186801|Clostridia,42GXZ@68295|Thermoanaerobacterales	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
GDHHQS1_k127_5552724_4	545695.TREAZ_3613	4.315e-76	268.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_5552724_5	1123368.AUIS01000006_gene566	4.258e-66	248.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,Response_reg
GDHHQS1_k127_5552724_6	1307761.L21SP2_1903	1.527e-51	190.0	COG0440@1|root,COG0440@2|Bacteria,2J7CQ@203691|Spirochaetes	203691|Spirochaetes	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
GDHHQS1_k127_5552724_0	665571.STHERM_c17170	1.648e-249	781.0	COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
GDHHQS1_k127_5568800_1	926549.KI421517_gene3390	1.548e-120	393.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_5568800_3	33898.JRHJ01000079_gene1278	3.87e-40	168.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
GDHHQS1_k127_5568800_6	1279009.ADICEAN_02457	8.5e-17	94.0	COG1840@1|root,COG1840@2|Bacteria,4NJ1Z@976|Bacteroidetes,47MBQ@768503|Cytophagia	976|Bacteroidetes	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6,SBP_bac_8
GDHHQS1_k127_5568800_7	2045.KR76_05840	3.255e-16	84.0	COG1959@1|root,COG1959@2|Bacteria,2IFQN@201174|Actinobacteria,4DSEN@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
GDHHQS1_k127_5568800_9	1307761.L21SP2_0818	1.279e-07	63.0	COG4656@1|root,COG4656@2|Bacteria,2J6BV@203691|Spirochaetes	203691|Spirochaetes	C	RnfC Barrel sandwich hybrid domain	-	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_17,Fer4_8,Fer4_9,NQR2_RnfD_RnfE,RnfC_N,SLBB
GDHHQS1_k127_5568800_5	903818.KI912268_gene2338	1.521e-21	102.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
GDHHQS1_k127_5568800_10	443143.GM18_0339	2.212e-05	55.0	COG0810@1|root,COG4254@1|root,COG0810@2|Bacteria,COG4254@2|Bacteria,1NATC@1224|Proteobacteria,42X7Q@68525|delta/epsilon subdivisions,2WS9F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
GDHHQS1_k127_5568800_2	760011.Spico_0147	3.356e-72	255.0	COG0327@1|root,COG0327@2|Bacteria,2J6QQ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM dinuclear metal center protein, YbgI SA1388 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
GDHHQS1_k127_5568800_0	1122915.AUGY01000068_gene6768	5.377e-138	458.0	COG1680@1|root,COG1680@2|Bacteria,1UUHI@1239|Firmicutes,4HNEC@91061|Bacilli,26QY8@186822|Paenibacillaceae	91061|Bacilli	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
GDHHQS1_k127_5568800_8	1293054.HSACCH_02637	3.431e-16	92.0	COG0793@1|root,COG0793@2|Bacteria,1UYV5@1239|Firmicutes,24B0A@186801|Clostridia,3WBSQ@53433|Halanaerobiales	186801|Clostridia	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
GDHHQS1_k127_5568800_11	323848.Nmul_A1582	0.0008195	42.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2WGMS@28216|Betaproteobacteria,3721D@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
GDHHQS1_k127_5570525_3	665571.STHERM_c11270	1.228e-90	332.0	COG2911@1|root,COG2911@2|Bacteria,2J5CF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Family of	-	-	-	-	-	-	-	-	-	-	-	-	TamB
GDHHQS1_k127_5570525_1	889378.Spiaf_1546	2.025e-210	685.0	COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane protein assembly complex, YaeT protein	yaeT	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
GDHHQS1_k127_5570525_6	1307761.L21SP2_1821	4.62e-19	94.0	COG2825@1|root,COG2825@2|Bacteria,2J7PA@203691|Spirochaetes	203691|Spirochaetes	M	Cationic outer membrane protein	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
GDHHQS1_k127_5570525_5	911045.PSE_3776	1.228e-19	100.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
GDHHQS1_k127_5570525_7	744872.Spica_1349	1.883e-17	89.0	COG1366@1|root,COG1366@2|Bacteria,2JAU8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
GDHHQS1_k127_5570525_0	545694.TREPR_2630	2.738e-268	852.0	COG0249@1|root,COG0249@2|Bacteria,2J5XM@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
GDHHQS1_k127_5570525_8	1430440.MGMSRv2_3575	1.242e-16	94.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2JSB6@204441|Rhodospirillales	204441|Rhodospirillales	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
GDHHQS1_k127_5570525_4	1480694.DC28_02040	1.865e-20	98.0	COG0779@1|root,COG0779@2|Bacteria,2J87E@203691|Spirochaetes	203691|Spirochaetes	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
GDHHQS1_k127_5570525_2	573413.Spirs_2027	4.656e-197	631.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
GDHHQS1_k127_5609506_1	1123274.KB899410_gene3574	9.671e-146	470.0	COG0115@1|root,COG0115@2|Bacteria,2J6WR@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
GDHHQS1_k127_5609506_2	1123274.KB899410_gene3573	4.165e-121	428.0	COG0457@1|root,COG0457@2|Bacteria,2J5XG@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
GDHHQS1_k127_5609506_6	573413.Spirs_3736	2.154e-34	142.0	COG0296@1|root,COG0296@2|Bacteria,2J5AV@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
GDHHQS1_k127_5609506_5	1047013.AQSP01000128_gene411	6.281e-35	142.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS1_k127_5609506_4	573413.Spirs_0330	3.703e-35	153.0	COG0204@1|root,COG0204@2|Bacteria,2JAJG@203691|Spirochaetes	203691|Spirochaetes	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
GDHHQS1_k127_5609506_9	1041522.MCOL_V206220	7.594e-19	98.0	COG3340@1|root,COG3340@2|Bacteria,2IC7Y@201174|Actinobacteria,234WT@1762|Mycobacteriaceae	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
GDHHQS1_k127_5609506_8	794903.OPIT5_20400	4.049e-24	120.0	COG1541@1|root,COG1541@2|Bacteria,46XXX@74201|Verrucomicrobia,3K79B@414999|Opitutae	414999|Opitutae	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
GDHHQS1_k127_5609506_0	545695.TREAZ_1519	0.0	1549.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,2J5M3@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN
GDHHQS1_k127_5609506_7	870187.Thini_3577	4.501e-28	117.0	COG3744@1|root,COG3744@2|Bacteria,1N349@1224|Proteobacteria,1T0BG@1236|Gammaproteobacteria,4635V@72273|Thiotrichales	72273|Thiotrichales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_5609506_10	240016.ABIZ01000001_gene424	8.049e-12	69.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
GDHHQS1_k127_5609506_3	1123274.KB899418_gene2367	2.749e-55	214.0	2E9WN@1|root,3342D@2|Bacteria,2J71N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5650812_4	1128421.JAGA01000003_gene3078	2.818e-81	281.0	COG1874@1|root,COG1874@2|Bacteria,2NP1U@2323|unclassified Bacteria	2|Bacteria	G	Beta-galactosidase trimerisation domain	bgaB	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
GDHHQS1_k127_5650812_5	1121859.KB890741_gene3709	1.212e-73	261.0	COG2159@1|root,COG2159@2|Bacteria,4NG9U@976|Bacteroidetes	976|Bacteroidetes	S	PFAM Amidohydrolase 2	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
GDHHQS1_k127_5650812_10	868131.MSWAN_0193	3.499e-12	75.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
GDHHQS1_k127_5650812_3	479434.Sthe_3148	4.054e-90	310.0	COG0428@1|root,COG0428@2|Bacteria,2G9IR@200795|Chloroflexi	200795|Chloroflexi	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5650812_2	1429046.RR21198_1534	3.606e-112	382.0	COG2132@1|root,COG2132@2|Bacteria,2GPUP@201174|Actinobacteria,4FYPQ@85025|Nocardiaceae	201174|Actinobacteria	Q	Multicopper oxidase	aniA	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
GDHHQS1_k127_5650812_7	1382356.JQMP01000004_gene217	1.01e-52	193.0	COG1321@1|root,COG1321@2|Bacteria,2G6N4@200795|Chloroflexi,27YBV@189775|Thermomicrobia	189775|Thermomicrobia	K	FeoA	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
GDHHQS1_k127_5650812_8	665571.STHERM_c05760	6.257e-35	146.0	COG0822@1|root,COG0822@2|Bacteria,2J7U2@203691|Spirochaetes	203691|Spirochaetes	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
GDHHQS1_k127_5650812_0	266117.Rxyl_0166	2.384e-147	482.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4CPE2@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
GDHHQS1_k127_5650812_9	665571.STHERM_c05740	1.414e-25	120.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
GDHHQS1_k127_5650812_6	1480694.DC28_14500	3.67e-58	225.0	COG0719@1|root,COG0719@2|Bacteria,2J5WQ@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
GDHHQS1_k127_5650812_1	1480694.DC28_14505	4.069e-128	412.0	COG0719@1|root,COG0719@2|Bacteria,2J5T1@203691|Spirochaetes	203691|Spirochaetes	O	assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
GDHHQS1_k127_5679062_2	485913.Krac_10280	1.386e-19	92.0	COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi	2|Bacteria	S	PFAM alpha beta hydrolase fold	MA20_20400	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Abhydrolase_6
GDHHQS1_k127_5679062_0	861299.J421_3685	7.587e-55	198.0	COG0231@1|root,COG0231@2|Bacteria,1ZT2N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
GDHHQS1_k127_5679062_3	743722.Sph21_1165	0.000179	51.0	COG4206@1|root,COG4206@2|Bacteria,4PKFW@976|Bacteroidetes,1J0MD@117747|Sphingobacteriia	976|Bacteroidetes	H	Outer membrane protein beta-barrel family	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3
GDHHQS1_k127_5679062_1	1379698.RBG1_1C00001G0584	4.097e-45	182.0	COG2373@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3386@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.4.24.40	ko:K01406,ko:K14274,ko:K20276,ko:K21449	ko00040,ko01503,ko02024,map00040,map01503,map02024	-	R02427	RC00713	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.40.2	-	-	Calx-beta,DUF4347,He_PIG,Ice_nucleation,SGL
GDHHQS1_k127_5686921_12	457570.Nther_2303	1.502e-49	184.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
GDHHQS1_k127_5686921_5	1118054.CAGW01000053_gene1477	2.772e-92	314.0	COG3191@1|root,COG3191@2|Bacteria,1TP60@1239|Firmicutes,4HD7F@91061|Bacilli,26V5I@186822|Paenibacillaceae	91061|Bacilli	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
GDHHQS1_k127_5686921_4	891968.Anamo_1589	3.389e-93	330.0	COG0413@1|root,COG0413@2|Bacteria,3T9V5@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
GDHHQS1_k127_5686921_7	401526.TcarDRAFT_1939	2.476e-78	273.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,4H595@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
GDHHQS1_k127_5686921_2	1408254.T458_01165	8.995e-128	420.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,2750F@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase dimerisation domain	dapE_3	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
GDHHQS1_k127_5686921_11	926550.CLDAP_29810	3.343e-59	219.0	COG0411@1|root,COG0411@2|Bacteria,2G5W6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS1_k127_5686921_6	545694.TREPR_0441	6.48e-90	302.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS1_k127_5686921_3	545694.TREPR_0442	1.498e-102	341.0	COG0559@1|root,COG0559@2|Bacteria	2|Bacteria	E	leucine import across plasma membrane	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS1_k127_5686921_9	545694.TREPR_0443	1.657e-70	267.0	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS1_k127_5686921_1	545694.TREPR_0444	5.928e-139	456.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
GDHHQS1_k127_5686921_18	754027.HMPREF9554_01610	1.09e-07	57.0	COG3027@1|root,COG3027@2|Bacteria,2J8Z5@203691|Spirochaetes	203691|Spirochaetes	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
GDHHQS1_k127_5686921_17	545695.TREAZ_0922	7.276e-08	63.0	28ZFQ@1|root,2ZM78@2|Bacteria,2J8CS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ZapB
GDHHQS1_k127_5686921_13	545694.TREPR_1647	1.219e-35	140.0	COG0292@1|root,COG0292@2|Bacteria,2J82V@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
GDHHQS1_k127_5686921_15	889378.Spiaf_0813	7.33e-22	96.0	COG0291@1|root,COG0291@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
GDHHQS1_k127_5686921_10	665571.STHERM_c07810	3.233e-70	243.0	COG0290@1|root,COG0290@2|Bacteria,2J76T@203691|Spirochaetes	203691|Spirochaetes	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
GDHHQS1_k127_5686921_14	215803.DB30_6191	6.815e-22	113.0	COG2114@1|root,COG2114@2|Bacteria,1Q6BC@1224|Proteobacteria,432SK@68525|delta/epsilon subdivisions,2WXUK@28221|Deltaproteobacteria,2YZ4T@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
GDHHQS1_k127_5686921_16	1123504.JQKD01000008_gene5422	2.766e-10	72.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2VN0T@28216|Betaproteobacteria,4AB27@80864|Comamonadaceae	28216|Betaproteobacteria	S	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,TPR_1,TPR_10,TPR_11,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
GDHHQS1_k127_5686921_8	906968.Trebr_0729	9.701e-74	254.0	COG0563@1|root,COG0563@2|Bacteria,2J6MV@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
GDHHQS1_k127_5686921_0	1191523.MROS_1378	1.585e-188	597.0	COG0499@1|root,COG0499@2|Bacteria	2|Bacteria	H	adenosylhomocysteinase activity	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
GDHHQS1_k127_5691750_2	1487923.DP73_21435	2.064e-12	79.0	COG0407@1|root,COG0407@2|Bacteria,1VPBU@1239|Firmicutes,24IYJ@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_5691750_0	1307761.L21SP2_3449	1.008e-154	501.0	COG2211@1|root,COG2211@2|Bacteria,2J5PU@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_5691750_1	545694.TREPR_0485	1.52e-32	133.0	COG2730@1|root,COG2730@2|Bacteria,2J6EW@203691|Spirochaetes	203691|Spirochaetes	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
GDHHQS1_k127_5707967_1	661367.LLO_2504	4.414e-88	301.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1JCER@118969|Legionellales	118969|Legionellales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
GDHHQS1_k127_5707967_0	247490.KSU1_C1370	1.95e-245	775.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
GDHHQS1_k127_5707967_2	234267.Acid_0710	1.08e-55	201.0	COG0329@1|root,COG0329@2|Bacteria,3Y6I2@57723|Acidobacteria	57723|Acidobacteria	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
GDHHQS1_k127_5713216_4	1226325.HMPREF1548_00033	1.048e-05	55.0	COG3170@1|root,COG3170@2|Bacteria,1US63@1239|Firmicutes,24YI9@186801|Clostridia	186801|Clostridia	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5713216_2	926550.CLDAP_35930	3.094e-49	195.0	COG1131@1|root,COG1131@2|Bacteria,2G5PC@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_5713216_0	215803.DB30_6505	7.429e-165	543.0	COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUHS@29|Myxococcales	28221|Deltaproteobacteria	D	5' nucleotidase family	surE2	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid
GDHHQS1_k127_5713216_1	1304885.AUEY01000002_gene436	3.59e-88	312.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2MHYS@213118|Desulfobacterales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
GDHHQS1_k127_5713216_3	671143.DAMO_1308	2.116e-20	93.0	COG0642@1|root,COG2205@2|Bacteria	671143.DAMO_1308|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5727685_26	1307759.JOMJ01000003_gene1234	1.784e-12	69.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,2M9DA@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
GDHHQS1_k127_5727685_12	1408473.JHXO01000010_gene3618	6.433e-74	263.0	COG0303@1|root,COG0303@2|Bacteria,4NDYD@976|Bacteroidetes	976|Bacteroidetes	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
GDHHQS1_k127_5727685_16	1499967.BAYZ01000161_gene394	8.068e-54	202.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	gtsA	-	3.6.3.30,3.6.3.55	ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112	ko02010,map02010	M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE_2
GDHHQS1_k127_5727685_17	1125863.JAFN01000001_gene2264	3.729e-51	201.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,42N6T@68525|delta/epsilon subdivisions,2WMKR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
GDHHQS1_k127_5727685_4	1125863.JAFN01000001_gene2036	6.023e-92	311.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WJ49@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
GDHHQS1_k127_5727685_24	945713.IALB_0360	1.233e-14	86.0	2E1HF@1|root,32WVJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3996
GDHHQS1_k127_5727685_20	1122919.KB905560_gene1455	3.461e-38	164.0	COG3533@1|root,COG3533@2|Bacteria,1VU2F@1239|Firmicutes,4I3KW@91061|Bacilli,26VY6@186822|Paenibacillaceae	91061|Bacilli	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127
GDHHQS1_k127_5727685_5	665571.STHERM_c03300	1.824e-91	315.0	COG3391@1|root,COG3391@2|Bacteria,2J5ZD@203691|Spirochaetes	203691|Spirochaetes	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
GDHHQS1_k127_5727685_0	309801.trd_1954	6.115e-121	397.0	COG0444@1|root,COG0444@2|Bacteria,2GBE3@200795|Chloroflexi,27Z2B@189775|Thermomicrobia	189775|Thermomicrobia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_5727685_1	1382356.JQMP01000001_gene959	5.827e-116	389.0	COG4608@1|root,COG4608@2|Bacteria,2GARG@200795|Chloroflexi,27Z3W@189775|Thermomicrobia	189775|Thermomicrobia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_5727685_3	1122962.AULH01000031_gene3964	8.278e-106	366.0	COG0747@1|root,COG0747@2|Bacteria,1R49R@1224|Proteobacteria,2U198@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS1_k127_5727685_9	309801.trd_1951	6.638e-86	296.0	COG0601@1|root,COG0601@2|Bacteria,2GAQS@200795|Chloroflexi,27YWJ@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS1_k127_5727685_14	290400.Jann_2055	1.994e-57	211.0	COG1173@1|root,COG1173@2|Bacteria,1R6BK@1224|Proteobacteria,2U30Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS1_k127_5727685_27	1501391.LG35_00580	5.385e-05	54.0	2CG1Y@1|root,2Z9QX@2|Bacteria,4NJI6@976|Bacteroidetes,2FPRX@200643|Bacteroidia,22UZB@171550|Rikenellaceae	976|Bacteroidetes	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
GDHHQS1_k127_5727685_15	697281.Mahau_2974	1.325e-56	223.0	COG2972@1|root,COG2972@2|Bacteria,1UYEW@1239|Firmicutes,24CU0@186801|Clostridia	186801|Clostridia	T	Histidine kinase- DNA gyrase B	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
GDHHQS1_k127_5727685_22	1122919.KB905563_gene2531	1.716e-26	127.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HI3Z@91061|Bacilli,274BP@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
GDHHQS1_k127_5727685_13	697281.Mahau_2970	1.051e-59	227.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5727685_6	697281.Mahau_2972	3.475e-90	313.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia,42J4C@68295|Thermoanaerobacterales	186801|Clostridia	U	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_5727685_10	697281.Mahau_2971	6.617e-82	283.0	COG0395@1|root,COG0395@2|Bacteria,1TP14@1239|Firmicutes,2481Z@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_5727685_23	436229.JOEH01000017_gene6941	1.923e-22	114.0	COG3345@1|root,COG3345@2|Bacteria,2HI4Y@201174|Actinobacteria,2NI4A@228398|Streptacidiphilus	201174|Actinobacteria	G	Melibiase	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase
GDHHQS1_k127_5727685_25	1125863.JAFN01000001_gene418	1.824e-13	85.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42N1X@68525|delta/epsilon subdivisions,2WKMS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase MttB (TMA methyltransferase)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
GDHHQS1_k127_5727685_28	748247.AZKH_1609	7.358e-05	55.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VM1W@28216|Betaproteobacteria,2KXH9@206389|Rhodocyclales	206389|Rhodocyclales	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
GDHHQS1_k127_5727685_18	525904.Tter_2509	1.513e-48	199.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase,Laminin_G_3,RicinB_lectin_2
GDHHQS1_k127_5727685_7	1125699.HMPREF9194_00152	6.628e-87	325.0	COG1397@1|root,COG1397@2|Bacteria,2J6S9@203691|Spirochaetes	203691|Spirochaetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
GDHHQS1_k127_5727685_2	556261.HMPREF0240_00122	7.701e-108	362.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_5727685_8	383372.Rcas_3813	4.374e-86	306.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	stsA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576	2.6.1.109	ko:K19715	-	-	R11395	RC00160	ko00000,ko01000,ko01005	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_5727685_19	1324957.K933_16217	2.322e-47	180.0	COG1082@1|root,arCOG01900@2157|Archaea,2XTYC@28890|Euryarchaeota,23UZ6@183963|Halobacteria	183963|Halobacteria	G	COG3622 Hydroxypyruvate isomerase	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_5727685_11	589865.DaAHT2_2487	1.589e-74	269.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
GDHHQS1_k127_5727685_21	324057.Pjdr2_2566	2.86e-28	114.0	COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,4IRIM@91061|Bacilli,26T43@186822|Paenibacillaceae	91061|Bacilli	O	Crystallin	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
GDHHQS1_k127_5741024_1	1125699.HMPREF9194_00902	1.193e-158	509.0	COG1653@1|root,COG1653@2|Bacteria,2JAFM@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
GDHHQS1_k127_5741024_6	1125699.HMPREF9194_00903	6.381e-87	295.0	COG0395@1|root,COG0395@2|Bacteria,2JAF4@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_5741024_3	1125699.HMPREF9194_00904	2.667e-111	366.0	COG4209@1|root,COG4209@2|Bacteria,2JA83@203691|Spirochaetes	203691|Spirochaetes	G	transmembrane transport	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_5741024_7	1125699.HMPREF9194_00905	1.023e-79	275.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
GDHHQS1_k127_5741024_0	909663.KI867150_gene718	6.077e-201	633.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2MRAN@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
GDHHQS1_k127_5741024_9	706587.Desti_4549	7.433e-26	113.0	COG3090@1|root,COG3090@2|Bacteria,1N9EF@1224|Proteobacteria,42WJB@68525|delta/epsilon subdivisions,2WRDN@28221|Deltaproteobacteria,2MS19@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
GDHHQS1_k127_5741024_2	706587.Desti_0319	1.437e-130	424.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42MVD@68525|delta/epsilon subdivisions,2WIY3@28221|Deltaproteobacteria,2MR71@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
GDHHQS1_k127_5741024_8	644282.Deba_0089	8.574e-52	210.0	COG2204@1|root,COG4191@1|root,COG4564@1|root,COG5000@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,COG4564@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,sCache_2
GDHHQS1_k127_5741024_5	886293.Sinac_7218	1.082e-94	331.0	COG2304@1|root,COG2304@2|Bacteria,2IYXD@203682|Planctomycetes	203682|Planctomycetes	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
GDHHQS1_k127_5741024_4	158189.SpiBuddy_0679	4.645e-109	371.0	2EWYX@1|root,33QA8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5742373_0	864702.OsccyDRAFT_2563	3.946e-245	788.0	COG1770@1|root,COG1770@2|Bacteria,1G1RH@1117|Cyanobacteria,1HE2Y@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
GDHHQS1_k127_5742373_1	1089550.ATTH01000001_gene1592	9.573e-74	252.0	COG1239@1|root,COG1239@2|Bacteria,4NF1J@976|Bacteroidetes,1FIU1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	magnesium chelatase	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Sigma54_activat
GDHHQS1_k127_5759415_4	1492922.GY26_07330	5.567e-33	130.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,1S58E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.34,5.3.1.6	ko:K01808,ko:K21911	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3353	LacAB_rpiB
GDHHQS1_k127_5759415_6	1050202.KB913024_gene2425	8.136e-21	105.0	COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria,409WM@622450|Actinopolysporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	blaB3	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS1_k127_5759415_5	926554.KI912674_gene2604	1.713e-32	140.0	COG0673@1|root,COG0673@2|Bacteria,1WJ56@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	COGs COG0673 dehydrogenase and related protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_5759415_2	665571.STHERM_c17040	1.781e-56	214.0	COG0796@1|root,COG0796@2|Bacteria,2J758@203691|Spirochaetes	203691|Spirochaetes	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
GDHHQS1_k127_5759415_0	1408473.JHXO01000011_gene2970	2.049e-65	241.0	COG0524@1|root,COG0524@2|Bacteria,4NGFK@976|Bacteroidetes,2FN72@200643|Bacteroidia	976|Bacteroidetes	G	Kinase, PfkB family	ydjH_1	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
GDHHQS1_k127_5759415_1	225937.HP15_1897	7.711e-65	237.0	COG3291@1|root,COG3828@1|root,COG3291@2|Bacteria,COG3828@2|Bacteria,1QUSE@1224|Proteobacteria	1224|Proteobacteria	G	PFAM FecR protein	-	-	3.2.1.4	ko:K01179,ko:K03933	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	AA10,CBM73,GH5,GH9	-	CBM_2,Calx-beta,Cellulase,PKD
GDHHQS1_k127_5759415_3	755731.Clo1100_0347	8.905e-47	185.0	COG1653@1|root,COG1653@2|Bacteria,1TSHR@1239|Firmicutes,24D6W@186801|Clostridia,36VR5@31979|Clostridiaceae	186801|Clostridia	G	Extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_5783062_25	1123376.AUIU01000018_gene29	1.402e-30	126.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	DinB_2,Metallophos_2
GDHHQS1_k127_5783062_16	889378.Spiaf_1828	5.259e-49	189.0	COG0345@1|root,COG0345@2|Bacteria,2J6DB@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
GDHHQS1_k127_5783062_0	573413.Spirs_2904	1.05e-168	540.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
GDHHQS1_k127_5783062_6	665571.STHERM_c00550	2.076e-73	263.0	COG2844@1|root,COG2844@2|Bacteria,2J5W2@203691|Spirochaetes	203691|Spirochaetes	O	HD domain	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD
GDHHQS1_k127_5783062_7	335543.Sfum_2043	5.37e-69	245.0	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,42WF3@68525|delta/epsilon subdivisions,2WS14@28221|Deltaproteobacteria,2MQY7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
GDHHQS1_k127_5783062_3	665571.STHERM_c00540	3.859e-142	464.0	COG0498@1|root,COG0498@2|Bacteria,2J63T@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
GDHHQS1_k127_5783062_5	269798.CHU_0074	3.411e-97	346.0	COG0083@1|root,COG0083@2|Bacteria,4NE2M@976|Bacteroidetes,47KGY@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
GDHHQS1_k127_5783062_2	665571.STHERM_c00530	2.808e-147	489.0	COG0527@1|root,COG0527@2|Bacteria,2J5C6@203691|Spirochaetes	203691|Spirochaetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
GDHHQS1_k127_5783062_9	1191523.MROS_1971	8.706e-66	227.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
GDHHQS1_k127_5783062_15	880072.Desac_1950	2.858e-49	189.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
GDHHQS1_k127_5783062_21	1536773.R70331_02165	3.12e-40	170.0	COG3437@1|root,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,4HB2P@91061|Bacilli,26SDZ@186822|Paenibacillaceae	91061|Bacilli	T	Chemotaxis protein CheY	rpfG	-	-	-	-	-	-	-	-	-	-	-	HAMP,HD
GDHHQS1_k127_5783062_10	880072.Desac_0427	1.384e-62	239.0	COG0784@1|root,COG1719@1|root,COG4191@1|root,COG0784@2|Bacteria,COG1719@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MRI2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction response regulator, receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,dCache_1
GDHHQS1_k127_5783062_20	1229172.JQFA01000002_gene4655	5.958e-41	166.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS1_k127_5783062_13	573370.DMR_02950	5.323e-56	220.0	COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2M7RD@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
GDHHQS1_k127_5783062_18	1125699.HMPREF9194_01864	3.538e-46	174.0	COG0293@1|root,COG0293@2|Bacteria,2J5SK@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
GDHHQS1_k127_5783062_14	573413.Spirs_0298	1.62e-51	194.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
GDHHQS1_k127_5783062_24	889378.Spiaf_0084	4.555e-31	136.0	2FBC5@1|root,343I0@2|Bacteria,2J6WZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5783062_4	573413.Spirs_4114	1.049e-122	412.0	COG4166@1|root,COG4166@2|Bacteria,2J5KU@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
GDHHQS1_k127_5783062_1	688269.Theth_1581	4.177e-153	520.0	COG0426@1|root,COG0426@2|Bacteria,2GCAS@200918|Thermotogae	200918|Thermotogae	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
GDHHQS1_k127_5783062_19	665571.STHERM_c18960	4.548e-44	169.0	COG0398@1|root,COG0398@2|Bacteria,2J8MX@203691|Spirochaetes	203691|Spirochaetes	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
GDHHQS1_k127_5783062_8	545694.TREPR_1023	2.137e-66	231.0	COG1329@1|root,COG1329@2|Bacteria,2J7TP@203691|Spirochaetes	203691|Spirochaetes	K	Transcription factor	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
GDHHQS1_k127_5783062_22	573413.Spirs_4117	1.773e-38	159.0	COG1211@1|root,COG1211@2|Bacteria,2J6JT@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the IspD TarI cytidylyltransferase family. IspD subfamily	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
GDHHQS1_k127_5783062_17	1183438.GKIL_3289	1.074e-47	186.0	COG0245@1|root,COG0245@2|Bacteria,1G4Z2@1117|Cyanobacteria	1117|Cyanobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
GDHHQS1_k127_5783062_12	706587.Desti_4119	9.106e-61	228.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42R18@68525|delta/epsilon subdivisions,2WN0H@28221|Deltaproteobacteria,2MRMP@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	endonuclease III	nth	-	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,Exo_endo_phos,HhH-GPD
GDHHQS1_k127_5783062_27	909663.KI867149_gene3376	3.22e-25	119.0	COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,42T10@68525|delta/epsilon subdivisions,2WPNN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4
GDHHQS1_k127_5783062_28	335541.Swol_0083	3.035e-09	63.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,42K0V@68298|Syntrophomonadaceae	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
GDHHQS1_k127_5783062_23	889378.Spiaf_0087	3.992e-33	134.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
GDHHQS1_k127_5783062_11	1123274.KB899438_gene649	3.385e-61	220.0	COG0106@1|root,COG0106@2|Bacteria,2J8GX@203691|Spirochaetes	203691|Spirochaetes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
GDHHQS1_k127_5783062_26	648996.Theam_1287	8.82e-27	117.0	COG0703@1|root,COG0703@2|Bacteria,2G46N@200783|Aquificae	200783|Aquificae	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
GDHHQS1_k127_5784037_0	935948.KE386494_gene745	1.319e-197	624.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,42FX4@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_5784037_1	1499967.BAYZ01000190_gene3853	2.217e-59	219.0	COG0407@1|root,COG0407@2|Bacteria,2NPXG@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_5784037_2	690850.Desaf_1643	3.867e-11	63.0	COG0642@1|root,COG0642@2|Bacteria,1R1IA@1224|Proteobacteria,43D9F@68525|delta/epsilon subdivisions,2X8G3@28221|Deltaproteobacteria,2MHI1@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
GDHHQS1_k127_5788097_9	867903.ThesuDRAFT_01176	4.415e-90	322.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
GDHHQS1_k127_5788097_7	555088.DealDRAFT_2005	1.815e-97	331.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
GDHHQS1_k127_5788097_17	1547437.LL06_25585	0.0003529	53.0	COG0697@1|root,COG0697@2|Bacteria,1R4G2@1224|Proteobacteria,2TTS7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS1_k127_5788097_11	211165.AJLN01000066_gene4475	6.347e-59	215.0	COG0561@1|root,COG0561@2|Bacteria,1GDI4@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
GDHHQS1_k127_5788097_16	420662.Mpe_A1365	1.157e-06	61.0	COG2002@1|root,COG2002@2|Bacteria,1NX4F@1224|Proteobacteria	1224|Proteobacteria	K	SpoVT / AbrB like domain	VL23_17280	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
GDHHQS1_k127_5788097_10	1304865.JAGF01000001_gene1100	2.599e-62	226.0	COG3440@1|root,COG3440@2|Bacteria	2|Bacteria	V	regulation of methylation-dependent chromatin silencing	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
GDHHQS1_k127_5788097_2	1279009.ADICEAN_00534	4.317e-155	504.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	isp	-	-	ko:K13275	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
GDHHQS1_k127_5788097_14	686340.Metal_3029	6.619e-26	112.0	COG1724@1|root,COG1724@2|Bacteria,1P3W9@1224|Proteobacteria,1SSC4@1236|Gammaproteobacteria,1XGPG@135618|Methylococcales	135618|Methylococcales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
GDHHQS1_k127_5788097_15	357808.RoseRS_1787	7.81e-19	98.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5788097_5	986075.CathTA2_2611	2.676e-107	372.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli	91061|Bacilli	P	Belongs to the ABC transporter superfamily	appF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_5788097_6	933115.GPDM_07590	3.228e-100	349.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26EEB@186818|Planococcaceae	91061|Bacilli	P	COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_5788097_8	207559.Dde_1183	1.243e-90	317.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,43B4R@68525|delta/epsilon subdivisions,2X5VN@28221|Deltaproteobacteria,2MGWB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
GDHHQS1_k127_5788097_4	207559.Dde_1184	3.746e-116	383.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria,2MG57@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	dppB	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS1_k127_5788097_1	400668.Mmwyl1_0114	2.014e-161	524.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1XIX9@135619|Oceanospirillales	135619|Oceanospirillales	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035,ko:K12368	ko02010,ko02024,ko02030,map02010,map02024,map02030	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS1_k127_5788097_3	96561.Dole_3272	5.961e-139	470.0	COG0784@1|root,COG2202@1|root,COG3437@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
GDHHQS1_k127_5788097_0	768671.ThimaDRAFT_1090	0.0	1139.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,1T2RH@1236|Gammaproteobacteria,1WW59@135613|Chromatiales	1236|Gammaproteobacteria	NT	PFAM CheB methylesterase	-	-	-	-	-	-	-	-	-	-	-	-	CheB_methylest,CheR,CheR_N,PAS,PAS_10,PAS_4
GDHHQS1_k127_5788097_13	316274.Haur_3795	5.035e-43	167.0	COG1528@1|root,COG1528@2|Bacteria,2G8JG@200795|Chloroflexi,37728@32061|Chloroflexia	32061|Chloroflexia	C	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
GDHHQS1_k127_5788097_12	690850.Desaf_3320	8.32e-44	164.0	COG2033@1|root,COG2033@2|Bacteria,1QNA5@1224|Proteobacteria,435XP@68525|delta/epsilon subdivisions,2X0EC@28221|Deltaproteobacteria,2MC18@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Desulfoferrodoxin	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
GDHHQS1_k127_5804883_6	1047013.AQSP01000114_gene706	4.451e-11	64.0	COG4710@1|root,COG4710@2|Bacteria	2|Bacteria	DJ	CopG domain protein DNA-binding domain protein	-	-	-	ko:K18918	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1,RHH_3,TraY
GDHHQS1_k127_5804883_1	573413.Spirs_2389	5.776e-83	282.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK,RadC
GDHHQS1_k127_5804883_2	1379698.RBG1_1C00001G0752	1.725e-46	173.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	cbiX	-	-	-	-	-	-	-	-	-	-	-	CbiX
GDHHQS1_k127_5804883_0	497964.CfE428DRAFT_4783	8.163e-90	310.0	COG3214@1|root,COG3214@2|Bacteria,46UTW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
GDHHQS1_k127_5804883_4	368407.Memar_0330	3.435e-42	167.0	arCOG02703@1|root,arCOG02703@2157|Archaea	2157|Archaea	S	Methyltransferase type 11	aknG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
GDHHQS1_k127_5804883_5	479434.Sthe_0834	1.117e-24	108.0	COG2050@1|root,COG2050@2|Bacteria,2G751@200795|Chloroflexi,27Z8E@189775|Thermomicrobia	189775|Thermomicrobia	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
GDHHQS1_k127_5804883_3	438753.AZC_0460	6.677e-43	169.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3EYVZ@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Glutamate synthase central domain	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
GDHHQS1_k127_5808770_5	1254432.SCE1572_30115	1.422e-09	62.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,1MW5Z@1224|Proteobacteria,42RM8@68525|delta/epsilon subdivisions,2WNZ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Guanylate_cyc,Hemerythrin
GDHHQS1_k127_5808770_3	880073.Calab_1429	1.255e-40	155.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.12.1.4,1.6.5.3	ko:K00334,ko:K17999	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
GDHHQS1_k127_5808770_0	1191523.MROS_2481	2.771e-236	752.0	COG1894@1|root,COG3411@1|root,COG1894@2|Bacteria,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	hoxF	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K05587,ko:K17992,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
GDHHQS1_k127_5808770_1	760568.Desku_2307	1.156e-209	666.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,2610M@186807|Peptococcaceae	186801|Clostridia	C	iron hydrogenase, small subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
GDHHQS1_k127_5808770_4	945713.IALB_0533	3.759e-20	95.0	COG0745@1|root,COG0745@2|Bacteria	945713.IALB_0533|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5808770_2	909663.KI867150_gene2881	1.505e-48	194.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
GDHHQS1_k127_5812536_1	545694.TREPR_1715	8.013e-130	427.0	COG0343@1|root,COG0343@2|Bacteria,2J5U0@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
GDHHQS1_k127_5812536_5	443143.GM18_1183	5.623e-55	210.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria,43TWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	GK	PFAM ROK family protein	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
GDHHQS1_k127_5812536_3	744872.Spica_1361	6.365e-73	267.0	COG0795@1|root,COG0795@2|Bacteria,2J64B@203691|Spirochaetes	203691|Spirochaetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
GDHHQS1_k127_5812536_2	889378.Spiaf_1533	4.366e-84	300.0	COG0795@1|root,COG0795@2|Bacteria,2J5F9@203691|Spirochaetes	203691|Spirochaetes	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
GDHHQS1_k127_5812536_10	1121013.P873_01295	1.644e-10	74.0	COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RQCR@1236|Gammaproteobacteria,1X4SZ@135614|Xanthomonadales	135614|Xanthomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Reg_prop,Y_Y_Y
GDHHQS1_k127_5812536_6	906968.Trebr_1252	1.153e-48	179.0	COG0756@1|root,COG0756@2|Bacteria,2J7JH@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
GDHHQS1_k127_5812536_4	906968.Trebr_1964	4.11e-72	271.0	COG0612@1|root,COG0612@2|Bacteria,2J6UV@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the peptidase M16 family	pqqL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
GDHHQS1_k127_5812536_0	573413.Spirs_2033	5.489e-278	873.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
GDHHQS1_k127_5812536_8	1123274.KB899421_gene1762	6.782e-27	114.0	COG0184@1|root,COG0184@2|Bacteria,2J91K@203691|Spirochaetes	203691|Spirochaetes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
GDHHQS1_k127_5812536_9	292564.Cyagr_1238	2.246e-23	115.0	COG0196@1|root,COG0196@2|Bacteria,1G0RB@1117|Cyanobacteria,22RYP@167375|Cyanobium	1117|Cyanobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
GDHHQS1_k127_5812536_7	545694.TREPR_1758	4.697e-44	169.0	COG0130@1|root,COG0130@2|Bacteria,2J7Q2@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
GDHHQS1_k127_5817302_0	697281.Mahau_2024	1.246e-116	398.0	COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia,42FZN@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.165,3.2.1.25	ko:K01192,ko:K15855	ko00511,ko00520,ko01100,ko04142,map00511,map00520,map01100,map04142	-	R01966	RC00049	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
GDHHQS1_k127_5817302_1	697281.Mahau_2859	2.898e-17	90.0	COG0407@1|root,COG0407@2|Bacteria	697281.Mahau_2859|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5835403_8	604354.TSIB_0629	2.537e-16	91.0	COG1180@1|root,arCOG00952@2157|Archaea,2XZW0@28890|Euryarchaeota,244ZY@183968|Thermococci	183968|Thermococci	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
GDHHQS1_k127_5835403_9	406124.ACPC01000017_gene601	0.0001013	53.0	COG0697@1|root,COG0697@2|Bacteria,1TRKD@1239|Firmicutes,4HA3N@91061|Bacilli,1ZER6@1386|Bacillus	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS1_k127_5835403_4	1307761.L21SP2_3058	1.031e-41	160.0	2DBC8@1|root,2Z8C9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5835403_6	1121382.JQKG01000035_gene3871	8.476e-19	87.0	2DBC8@1|root,2Z8C9@2|Bacteria,1WKX1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5835403_2	401526.TcarDRAFT_1716	1.914e-76	266.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,4H2DY@909932|Negativicutes	909932|Negativicutes	C	Phosphate acetyl/butaryl transferase	ptb	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
GDHHQS1_k127_5835403_5	251221.35214371	1.119e-35	140.0	COG3744@1|root,COG3744@2|Bacteria,1G9I2@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_5835403_7	1282360.ABAC460_08205	8.317e-17	85.0	COG4118@1|root,COG4118@2|Bacteria,1NME9@1224|Proteobacteria,2UMMS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
GDHHQS1_k127_5835403_0	665571.STHERM_c21530	1.003e-161	536.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
GDHHQS1_k127_5835403_3	665571.STHERM_c21540	3.882e-74	268.0	COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS1_k127_5835403_1	665571.STHERM_c21550	2.2e-95	321.0	COG0331@1|root,COG0331@2|Bacteria,2J5E6@203691|Spirochaetes	203691|Spirochaetes	I	Malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
GDHHQS1_k127_5844104_0	1259795.ARJK01000004_gene1361	1.218e-79	268.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,42ET1@68295|Thermoanaerobacterales	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
GDHHQS1_k127_5844104_2	1131814.JAFO01000001_gene2573	6.857e-19	95.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	5.3.3.19	ko:K19547	ko01130,map01130	M00787	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,HATPase_c,His_kinase,PocR
GDHHQS1_k127_5844104_3	881621.LIV_2774	0.0005502	47.0	COG1609@1|root,COG1609@2|Bacteria,1TPZM@1239|Firmicutes,4H9ZT@91061|Bacilli,26IPD@186820|Listeriaceae	91061|Bacilli	K	Transcriptional regulator	malR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
GDHHQS1_k127_5844104_1	926569.ANT_06990	3.346e-41	154.0	COG2317@1|root,COG2317@2|Bacteria,2G7UQ@200795|Chloroflexi	200795|Chloroflexi	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
GDHHQS1_k127_5882704_0	1120950.KB892742_gene3002	2.913e-279	885.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria,4DPD7@85009|Propionibacteriales	201174|Actinobacteria	G	Beta galactosidase small chain	lacZ	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
GDHHQS1_k127_5882704_1	1122223.KB890698_gene914	4.198e-33	130.0	COG1764@1|root,COG1764@2|Bacteria,1WJVD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	redox protein regulator of disulfide bond formation	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
GDHHQS1_k127_5929371_1	744872.Spica_1386	2.063e-137	446.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
GDHHQS1_k127_5929371_2	906968.Trebr_1355	7.096e-101	344.0	COG0772@1|root,COG0772@2|Bacteria,2J62H@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family. MrdB RodA subfamily	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
GDHHQS1_k127_5929371_0	573413.Spirs_2070	8.51e-199	644.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2J5YW@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
GDHHQS1_k127_5929371_3	889378.Spiaf_0934	5.76e-72	256.0	COG1694@1|root,COG3956@2|Bacteria,2J5HG@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM MazG family protein	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
GDHHQS1_k127_5929371_4	373903.Hore_20290	3.97e-14	75.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,3WAK7@53433|Halanaerobiales	186801|Clostridia	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
GDHHQS1_k127_593447_7	665571.STHERM_c08880	2.811e-35	143.0	COG2227@1|root,COG2227@2|Bacteria,2J6CB@203691|Spirochaetes	203691|Spirochaetes	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
GDHHQS1_k127_593447_8	526224.Bmur_0013	4.462e-22	110.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K08642	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M23
GDHHQS1_k127_593447_9	545695.TREAZ_0855	1.16e-17	96.0	2C8R1@1|root,2ZG03@2|Bacteria,2J6QN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_593447_6	906968.Trebr_1664	3.111e-36	143.0	COG0295@1|root,COG0295@2|Bacteria,2J80W@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
GDHHQS1_k127_593447_2	889378.Spiaf_2129	2.481e-75	282.0	2E1YA@1|root,32X70@2|Bacteria,2J5Q9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_593447_0	573413.Spirs_1535	3.64e-147	490.0	COG0497@1|root,COG0497@2|Bacteria,2J5E5@203691|Spirochaetes	203691|Spirochaetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
GDHHQS1_k127_593447_3	158189.SpiBuddy_1252	2.37e-74	260.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
GDHHQS1_k127_593447_4	573413.Spirs_1533	3.168e-67	246.0	COG0399@1|root,COG0399@2|Bacteria,2J6I3@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_593447_5	317025.Tcr_1069	4.862e-56	202.0	COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,1RNDR@1236|Gammaproteobacteria,45ZNR@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT
GDHHQS1_k127_593447_1	1123274.KB899413_gene886	1.743e-78	278.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like,Usp
GDHHQS1_k127_593447_10	1229758.C270_03020	1.266e-10	72.0	COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,4HB8K@91061|Bacilli,4AXGS@81850|Leuconostocaceae	91061|Bacilli	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
GDHHQS1_k127_5944530_1	990073.ATHU01000002_gene68	2.974e-07	61.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,42RF8@68525|delta/epsilon subdivisions,2YP7F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	KT	Chemotaxis protein cheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
GDHHQS1_k127_5944530_0	545695.TREAZ_1298	7.344e-52	199.0	2F39Z@1|root,33W49@2|Bacteria,2J8PJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5992696_2	1307761.L21SP2_1651	7.476e-117	391.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_5992696_1	665571.STHERM_c06640	3.328e-130	445.0	COG4254@1|root,COG4254@2|Bacteria,2J9KS@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
GDHHQS1_k127_5992696_0	1480694.DC28_11095	1.541e-131	439.0	COG0323@1|root,COG0323@2|Bacteria,2J5XE@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
GDHHQS1_k127_5992696_5	1122237.AUGQ01000005_gene1327	9.622e-07	53.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
GDHHQS1_k127_5992696_4	543632.JOJL01000097_gene5167	1.97e-08	57.0	COG4974@1|root,COG4974@2|Bacteria,2IGA2@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_6021342_6	1123274.KB899421_gene1770	9.861e-41	173.0	COG2304@1|root,COG2304@2|Bacteria,2J67D@203691|Spirochaetes	203691|Spirochaetes	K	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
GDHHQS1_k127_6021342_0	573413.Spirs_2041	1.879e-307	966.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,2J5MW@203691|Spirochaetes	203691|Spirochaetes	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
GDHHQS1_k127_6021342_1	744872.Spica_1366	6.217e-79	275.0	COG0457@1|root,COG0457@2|Bacteria,2J7GS@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
GDHHQS1_k127_6021342_2	545695.TREAZ_0531	1.6e-74	256.0	COG0036@1|root,COG0036@2|Bacteria,2J7B7@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
GDHHQS1_k127_6021342_7	573413.Spirs_2047	2.679e-36	153.0	COG1729@1|root,COG1729@2|Bacteria,2J5PP@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
GDHHQS1_k127_6021342_4	1123274.KB899421_gene1778	2.595e-52	205.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cohesin,DUF11,SLH
GDHHQS1_k127_6021342_3	573413.Spirs_2049	1.936e-74	278.0	COG0457@1|root,COG0457@2|Bacteria,2J5D0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_2
GDHHQS1_k127_6021342_5	264732.Moth_1679	9.91e-42	168.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,42GII@68295|Thermoanaerobacterales	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
GDHHQS1_k127_6021342_8	379066.GAU_0824	4.535e-14	74.0	COG1194@1|root,COG1194@2|Bacteria,1ZTNM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
GDHHQS1_k127_6031296_1	665571.STHERM_c18650	3.177e-81	285.0	COG0042@1|root,COG0042@2|Bacteria,2J691@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
GDHHQS1_k127_6031296_0	573413.Spirs_3191	1.51e-115	377.0	COG0084@1|root,COG0084@2|Bacteria,2J68W@203691|Spirochaetes	203691|Spirochaetes	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
GDHHQS1_k127_6031296_2	744872.Spica_0040	6.283e-64	232.0	COG0739@1|root,COG0739@2|Bacteria,2J5SN@203691|Spirochaetes	203691|Spirochaetes	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
GDHHQS1_k127_6031296_4	1123274.KB899431_gene3277	6.677e-40	152.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
GDHHQS1_k127_6031296_5	1487923.DP73_06660	1.879e-06	56.0	COG1728@1|root,COG1728@2|Bacteria,1VF6M@1239|Firmicutes,25DMP@186801|Clostridia,26221@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF327)	-	-	-	ko:K09770	-	-	-	-	ko00000	-	-	-	DUF327
GDHHQS1_k127_6031296_3	744872.Spica_0043	4.68e-57	209.0	COG1774@1|root,COG1774@2|Bacteria,2J5RE@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
GDHHQS1_k127_6049106_8	665571.STHERM_c02000	1.481e-66	238.0	COG1242@1|root,COG1242@2|Bacteria,2J6Y8@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM radical SAM protein, TIGR01212 family	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
GDHHQS1_k127_6049106_10	744872.Spica_2384	2.642e-35	141.0	2AMDJ@1|root,31C90@2|Bacteria,2J6DK@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_6049106_4	1123274.KB899411_gene3047	8.776e-136	444.0	COG0436@1|root,COG0436@2|Bacteria,2J5R0@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
GDHHQS1_k127_6049106_2	706587.Desti_3602	1.458e-214	680.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
GDHHQS1_k127_6049106_9	744872.Spica_1647	1.828e-55	196.0	COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
GDHHQS1_k127_6049106_3	1499967.BAYZ01000119_gene3219	1.771e-179	571.0	COG0004@1|root,COG0004@2|Bacteria,2NP8F@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
GDHHQS1_k127_6049106_1	665571.STHERM_c21600	1.055e-293	914.0	COG1274@1|root,COG1274@2|Bacteria,2J5BB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
GDHHQS1_k127_6049106_7	665571.STHERM_c03320	4.362e-72	255.0	2EYH2@1|root,33RQY@2|Bacteria,2J9M4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_6049106_5	545695.TREAZ_0071	1.846e-121	405.0	COG0771@1|root,COG0771@2|Bacteria,2J5IW@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
GDHHQS1_k127_6049106_0	439235.Dalk_4850	0.0	1158.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
GDHHQS1_k127_6049106_6	552811.Dehly_1194	2.39e-78	269.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
GDHHQS1_k127_6049106_12	497964.CfE428DRAFT_3099	1.202e-08	59.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
GDHHQS1_k127_6049106_11	177437.HRM2_02250	5.072e-14	72.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42RPD@68525|delta/epsilon subdivisions,2WNI0@28221|Deltaproteobacteria,2MK1B@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
GDHHQS1_k127_6057510_14	1125700.HMPREF9195_02018	2.106e-26	121.0	COG2885@1|root,COG2885@2|Bacteria,2J5X0@203691|Spirochaetes	203691|Spirochaetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
GDHHQS1_k127_6057510_10	545695.TREAZ_3370	2.606e-74	275.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2J5H1@203691|Spirochaetes	203691|Spirochaetes	M	Transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
GDHHQS1_k127_6057510_11	573413.Spirs_2857	7.531e-68	258.0	COG0457@1|root,COG0457@2|Bacteria,2J5XK@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_8
GDHHQS1_k127_6057510_1	665571.STHERM_c18430	7.095e-168	557.0	COG0538@1|root,COG0538@2|Bacteria,2J5RP@203691|Spirochaetes	203691|Spirochaetes	C	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
GDHHQS1_k127_6057510_15	889378.Spiaf_1816	1.357e-21	110.0	2AMU1@1|root,31CQJ@2|Bacteria,2J8GB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_6057510_5	889378.Spiaf_0091	3.885e-134	450.0	COG1306@1|root,COG1306@2|Bacteria,2J5BQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
GDHHQS1_k127_6057510_3	744872.Spica_2556	1.091e-148	521.0	COG1413@1|root,COG2211@1|root,COG1413@2|Bacteria,COG2211@2|Bacteria,2J9QA@203691|Spirochaetes	203691|Spirochaetes	CG	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
GDHHQS1_k127_6057510_8	158189.SpiBuddy_2723	3.637e-90	325.0	COG0826@1|root,COG0826@2|Bacteria,2J667@203691|Spirochaetes	203691|Spirochaetes	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
GDHHQS1_k127_6057510_13	665571.STHERM_c21800	5.688e-55	203.0	COG0791@1|root,COG0791@2|Bacteria,2JB19@203691|Spirochaetes	203691|Spirochaetes	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,NLPC_P60
GDHHQS1_k127_6057510_2	189425.PGRAT_23740	4.341e-163	541.0	COG3408@1|root,COG3408@2|Bacteria,1TSSU@1239|Firmicutes,4HCTS@91061|Bacilli,26RHX@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	ram2	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
GDHHQS1_k127_6057510_0	1499967.BAYZ01000077_gene871	4.555e-295	929.0	COG3250@1|root,COG3250@2|Bacteria,2NNR1@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolases family 2	manB2	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
GDHHQS1_k127_6057510_12	748449.Halha_2501	3.212e-64	232.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
GDHHQS1_k127_6057510_7	1280390.CBQR020000101_gene2396	8.241e-94	316.0	COG0395@1|root,COG0395@2|Bacteria,1TPHS@1239|Firmicutes,4HF83@91061|Bacilli,26RB4@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_6057510_6	658086.HMPREF0994_06788	3.751e-100	336.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_6057510_9	588581.Cpap_3326	1.448e-76	277.0	COG1653@1|root,COG1653@2|Bacteria,1TSF4@1239|Firmicutes,24DIH@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
GDHHQS1_k127_6057510_4	1122919.KB905624_gene95	3.325e-140	467.0	COG4225@1|root,COG4225@2|Bacteria,1TPTR@1239|Firmicutes,4HEFB@91061|Bacilli,26TI0@186822|Paenibacillaceae	91061|Bacilli	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
GDHHQS1_k127_6057510_16	1288826.MSNKSG1_07353	2.069e-21	105.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,465G5@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	amidohydrolase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
GDHHQS1_k127_6072814_4	1321778.HMPREF1982_01904	2.703e-05	46.0	COG1814@1|root,COG1814@2|Bacteria,1V4D2@1239|Firmicutes	1239|Firmicutes	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
GDHHQS1_k127_6072814_3	479434.Sthe_2603	7.548e-26	117.0	COG3595@1|root,COG3595@2|Bacteria,2G73J@200795|Chloroflexi	200795|Chloroflexi	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
GDHHQS1_k127_6072814_0	1167006.UWK_00092	2.081e-138	450.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MHQS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
GDHHQS1_k127_6072814_1	589865.DaAHT2_0104	2.091e-108	359.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MJJN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS1_k127_6072814_2	589865.DaAHT2_0103	9.843e-58	220.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42TE0@68525|delta/epsilon subdivisions,2WPEP@28221|Deltaproteobacteria,2MKDG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS1_k127_6104648_7	760568.Desku_2340	1.773e-31	137.0	arCOG09742@1|root,2ZBGR@2|Bacteria,1V0RW@1239|Firmicutes,24AYH@186801|Clostridia,263KV@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_6104648_11	1307761.L21SP2_0672	0.0001686	48.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1,Y2_Tnp,Zn_Tnp_IS91
GDHHQS1_k127_6104648_9	1047013.AQSP01000049_gene2263	2.986e-06	50.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1,Y2_Tnp,Zn_Tnp_IS91
GDHHQS1_k127_6104648_12	1535422.ND16A_2175	0.0006089	44.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2Q64M@267889|Colwelliaceae	1236|Gammaproteobacteria	U	AAA domain	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1,T2SSB
GDHHQS1_k127_6104648_2	660470.Theba_2561	7.825e-139	465.0	COG1307@1|root,COG1461@1|root,COG1307@2|Bacteria,COG1461@2|Bacteria,2GC94@200918|Thermotogae	2|Bacteria	S	DAK2 domain fusion protein YloV	yfhG	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2,DegV
GDHHQS1_k127_6104648_4	1307761.L21SP2_2808	6.469e-67	238.0	COG3752@1|root,COG3752@2|Bacteria,2J9PV@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
GDHHQS1_k127_6104648_6	290512.Paes_2175	8.769e-34	139.0	COG0344@1|root,COG0344@2|Bacteria,1FDRT@1090|Chlorobi	1090|Chlorobi	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
GDHHQS1_k127_6104648_3	649638.Trad_1460	1.214e-105	361.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1WM48@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
GDHHQS1_k127_6104648_0	573413.Spirs_3695	1.226e-196	637.0	COG1022@1|root,COG1022@2|Bacteria,2J9S5@203691|Spirochaetes	203691|Spirochaetes	I	Long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS1_k127_6104648_1	382464.ABSI01000010_gene3515	2.358e-185	607.0	2F006@1|root,33T46@2|Bacteria,46U4Y@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_6104648_8	1041930.Mtc_0968	4.823e-25	114.0	arCOG00787@1|root,arCOG00787@2157|Archaea	2157|Archaea	L	UvrD REP helicase	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
GDHHQS1_k127_6104648_5	935863.AWZR01000009_gene8	3.12e-37	151.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1X3AV@135614|Xanthomonadales	135614|Xanthomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
GDHHQS1_k127_6314145_1	1267534.KB906756_gene625	5.096e-122	406.0	COG1063@1|root,COG1063@2|Bacteria,3Y6II@57723|Acidobacteria,2JKQW@204432|Acidobacteriia	204432|Acidobacteriia	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_6314145_2	1396418.BATQ01000130_gene4880	2.337e-115	388.0	COG3875@1|root,COG3875@2|Bacteria,46TVY@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
GDHHQS1_k127_6314145_0	1499967.BAYZ01000147_gene687	2.19e-142	493.0	2EDIX@1|root,337ET@2|Bacteria	2|Bacteria	S	tagaturonate epimerase	-	-	-	-	-	-	-	-	-	-	-	-	UxaE
GDHHQS1_k127_6314145_3	545694.TREPR_1711	8.583e-06	56.0	2ANZ6@1|root,31E07@2|Bacteria,2JB87@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_6347895_3	697281.Mahau_1209	8.72e-05	50.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_6347895_0	1123274.KB899409_gene635	3.726e-73	255.0	COG0670@1|root,COG0670@2|Bacteria,2J7GY@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
GDHHQS1_k127_6347895_1	744872.Spica_0292	2.241e-71	257.0	COG5522@1|root,COG5522@2|Bacteria	2|Bacteria	S	Integral membrane protein (intg_mem_TP0381)	ywaF	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
GDHHQS1_k127_6347895_2	545695.TREAZ_2569	1.116e-07	53.0	COG0407@1|root,COG0407@2|Bacteria,2JA7B@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_6413404_2	665571.STHERM_c19900	2.215e-44	171.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2J8CK@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
GDHHQS1_k127_6413404_3	1307761.L21SP2_1378	5.734e-35	138.0	COG1664@1|root,COG1664@2|Bacteria,2J85N@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
GDHHQS1_k127_6413404_5	573413.Spirs_3182	7.366e-25	105.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4071,GAF,Guanylate_cyc,Pkinase,dCache_1
GDHHQS1_k127_6413404_1	1480694.DC28_03065	1.206e-84	292.0	COG0745@1|root,COG0745@2|Bacteria,2J7JA@203691|Spirochaetes	203691|Spirochaetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
GDHHQS1_k127_6413404_0	665571.STHERM_c18560	4.698e-164	533.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
GDHHQS1_k127_6413404_4	760011.Spico_1237	5.811e-31	124.0	COG0776@1|root,COG0776@2|Bacteria,2J7PW@203691|Spirochaetes	203691|Spirochaetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K04764,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
GDHHQS1_k127_6413404_7	1480694.DC28_03055	4.801e-13	72.0	COG0268@1|root,COG0268@2|Bacteria,2J84G@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
GDHHQS1_k127_6413404_6	744872.Spica_1614	5.524e-18	93.0	COG5360@1|root,COG5360@2|Bacteria,2J6PR@203691|Spirochaetes	203691|Spirochaetes	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_6544298_2	177437.HRM2_06330	1.885e-78	280.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42QQQ@68525|delta/epsilon subdivisions,2WMBP@28221|Deltaproteobacteria,2MIM7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS1_k127_6544298_0	665571.STHERM_c19110	4.133e-187	601.0	COG3845@1|root,COG3845@2|Bacteria	2|Bacteria	P	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
GDHHQS1_k127_6544298_1	665571.STHERM_c19120	1.52e-168	539.0	COG1744@1|root,COG1744@2|Bacteria,2J7UH@203691|Spirochaetes	203691|Spirochaetes	S	Membrane protein, bmp family	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
GDHHQS1_k127_6544298_3	391625.PPSIR1_24484	1.313e-30	123.0	COG3392@1|root,COG3392@2|Bacteria,1R6P4@1224|Proteobacteria,42ND7@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	DNA methyltransferase	fokIM	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
GDHHQS1_k127_6573493_8	1122915.AUGY01000009_gene4890	1.774e-21	105.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1U766@1239|Firmicutes,4ISKZ@91061|Bacilli,27663@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	rr09	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
GDHHQS1_k127_6573493_5	572479.Hprae_0084	2.588e-40	152.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3WBW4@53433|Halanaerobiales	186801|Clostridia	K	PFAM Silent information regulator protein Sir2	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
GDHHQS1_k127_6573493_4	1267534.KB906757_gene993	5.422e-74	264.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	MA20_35850	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS1_k127_6573493_3	717605.Theco_1688	5.368e-96	325.0	COG0684@1|root,COG0684@2|Bacteria,1UY1F@1239|Firmicutes,4I6H6@91061|Bacilli,26T30@186822|Paenibacillaceae	91061|Bacilli	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
GDHHQS1_k127_6573493_9	1232410.KI421413_gene747	5.579e-17	93.0	COG2006@1|root,COG2006@2|Bacteria,1R7BH@1224|Proteobacteria,42QGJ@68525|delta/epsilon subdivisions,2WJ1A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
GDHHQS1_k127_6573493_0	697281.Mahau_2102	1.413e-190	605.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia,42ES0@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Mandelate racemase muconate lactonizing enzyme	-	-	4.2.1.5,4.2.1.6,4.2.1.8	ko:K01683,ko:K01684,ko:K08323	ko00040,ko00052,ko01100,ko01120,map00040,map00052,map01100,map01120	M00061,M00552	R03033,R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS1_k127_6573493_10	744872.Spica_2481	2.101e-09	68.0	2BRF6@1|root,32KE2@2|Bacteria,2J8NK@203691|Spirochaetes	203691|Spirochaetes	M	Domain of unknown function (DUF4398)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
GDHHQS1_k127_6573493_7	485914.Hmuk_3414	5.278e-32	136.0	COG0613@1|root,arCOG00302@2157|Archaea	2157|Archaea	E	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,CarboxypepD_reg,DDOST_48kD
GDHHQS1_k127_6573493_1	926569.ANT_16800	2.367e-190	606.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
GDHHQS1_k127_6573493_2	1128421.JAGA01000002_gene784	2.959e-156	515.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
GDHHQS1_k127_6573493_6	1307761.L21SP2_0011	1.886e-36	141.0	COG0509@1|root,COG0509@2|Bacteria,2J8D7@203691|Spirochaetes	203691|Spirochaetes	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
GDHHQS1_k127_6573493_11	1408419.JHYG01000004_gene1497	5.384e-05	48.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,2JQ8S@204441|Rhodospirillales	204441|Rhodospirillales	E	Glycine cleavage system T protein	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
GDHHQS1_k127_662293_4	909663.KI867150_gene1166	7.32e-34	138.0	COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,42W6K@68525|delta/epsilon subdivisions,2WS34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
GDHHQS1_k127_662293_5	744872.Spica_0029	1.802e-33	137.0	COG0824@1|root,COG0824@2|Bacteria,2J837@203691|Spirochaetes	203691|Spirochaetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
GDHHQS1_k127_662293_3	545694.TREPR_0598	1.961e-44	172.0	COG0328@1|root,COG0328@2|Bacteria,2J7Y2@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
GDHHQS1_k127_662293_1	1382306.JNIM01000001_gene1575	4.616e-129	430.0	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi	200795|Chloroflexi	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
GDHHQS1_k127_662293_2	665571.STHERM_c05270	2.682e-121	402.0	COG0265@1|root,COG0265@2|Bacteria,2J6JY@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
GDHHQS1_k127_662293_0	665571.STHERM_c05280	2.63e-284	901.0	COG0556@1|root,COG0556@2|Bacteria,2J57B@203691|Spirochaetes	203691|Spirochaetes	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
GDHHQS1_k127_662293_7	1123274.KB899422_gene111	2.763e-13	83.0	COG3103@1|root,COG3103@2|Bacteria	2|Bacteria	T	Sh3 type 3 domain protein	batE	-	-	-	-	-	-	-	-	-	-	-	BatD,Phenol_MetA_deg,SH3_3,SH3_4,TPR_16,TPR_2
GDHHQS1_k127_662293_6	545695.TREAZ_0638	5.791e-25	117.0	COG4399@1|root,COG4399@2|Bacteria,2JAAN@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
GDHHQS1_k127_6848637_2	1125700.HMPREF9195_00080	1.705e-89	309.0	COG3276@1|root,COG3276@2|Bacteria,2J5YI@203691|Spirochaetes	203691|Spirochaetes	J	translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,SelB-wing_3
GDHHQS1_k127_6848637_1	1448139.AI20_06870	9.109e-117	394.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,1RN73@1236|Gammaproteobacteria,1Y5MI@135624|Aeromonadales	135624|Aeromonadales	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
GDHHQS1_k127_6848637_0	264732.Moth_0722	1.128e-117	402.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
GDHHQS1_k127_6848637_5	558152.IQ37_04455	3.316e-47	182.0	2DB8K@1|root,2Z7S1@2|Bacteria,4NI7A@976|Bacteroidetes,1I0N2@117743|Flavobacteriia,3ZRFB@59732|Chryseobacterium	976|Bacteroidetes	I	Streptomycin adenylyltransferase	aadK	-	-	ko:K05593	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Adenyl_transf
GDHHQS1_k127_6848637_3	1365176.N186_04140	2.369e-74	257.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS1_k127_6848637_4	575540.Isop_2345	2.904e-50	184.0	COG0160@1|root,COG0160@2|Bacteria,2IYBU@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS1_k127_6848637_7	1123274.KB899430_gene1693	3.069e-12	80.0	COG1522@1|root,COG1522@2|Bacteria,2JADV@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_AsnC-type
GDHHQS1_k127_6848637_6	525897.Dbac_2014	5.096e-29	119.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,2M8HV@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS1_k127_6908457_3	1210884.HG799462_gene8571	6.608e-142	456.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_6908457_2	243231.GSU0193	5.315e-166	529.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,42MU3@68525|delta/epsilon subdivisions,2WKTF@28221|Deltaproteobacteria,43SSU@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
GDHHQS1_k127_6908457_4	1265505.ATUG01000003_gene610	3.99e-22	105.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
GDHHQS1_k127_6908457_1	880073.Calab_2883	7.933e-177	589.0	COG0493@1|root,COG0493@2|Bacteria,2NNUI@2323|unclassified Bacteria	2|Bacteria	E	Flavin containing amine oxidoreductase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
GDHHQS1_k127_6908457_0	880073.Calab_2882	0.0	1814.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2NP08@2323|unclassified Bacteria	2|Bacteria	E	Glutamate synthase central domain	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
GDHHQS1_k127_6981541_0	335541.Swol_0657	3.93e-121	397.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42KH9@68298|Syntrophomonadaceae	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
GDHHQS1_k127_6981541_2	555079.Toce_0241	1.143e-44	177.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24I29@186801|Clostridia,42ICW@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
GDHHQS1_k127_6981541_1	596324.TREVI0001_0151	7.078e-52	195.0	COG0514@1|root,COG0514@2|Bacteria,2J5BY@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
GDHHQS1_k127_713829_3	1047013.AQSP01000109_gene2440	3.589e-24	104.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
GDHHQS1_k127_713829_1	552811.Dehly_1422	4.068e-82	281.0	COG0500@1|root,COG2226@2|Bacteria,2G6GD@200795|Chloroflexi,34CS0@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
GDHHQS1_k127_713829_2	1379698.RBG1_1C00001G0613	2.849e-50	184.0	COG1268@1|root,COG1268@2|Bacteria,2NPGG@2323|unclassified Bacteria	2|Bacteria	S	BioY family	bioY	-	-	ko:K02014,ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	1.B.14,2.A.88.1,2.A.88.2	-	-	BioY
GDHHQS1_k127_713829_0	1304880.JAGB01000003_gene1262	1.179e-94	313.0	28KX8@1|root,2ZAD8@2|Bacteria,1U7ZE@1239|Firmicutes,24DFK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7159838_2	545695.TREAZ_2088	1.776e-59	211.0	COG0714@1|root,COG0714@2|Bacteria,2J65W@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
GDHHQS1_k127_7159838_3	1123242.JH636435_gene2167	2.466e-06	59.0	COG2010@1|root,COG4654@1|root,COG2010@2|Bacteria,COG4654@2|Bacteria,2IYSS@203682|Planctomycetes	203682|Planctomycetes	C	Protein of unknown function (DUF1549)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1
GDHHQS1_k127_7159838_0	926569.ANT_29680	4.078e-208	679.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi	200795|Chloroflexi	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_7159838_1	926569.ANT_29670	6.546e-127	414.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_7178767_0	404589.Anae109_3474	3.35e-113	393.0	COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,42U1I@68525|delta/epsilon subdivisions,2WQQV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	7 transmembrane helices usually fused to an inactive transglutaminase	-	-	-	-	-	-	-	-	-	-	-	-	7TM_transglut,Transglut_core,Transglut_i_TM
GDHHQS1_k127_7178767_1	290397.Adeh_3414	1.805e-82	297.0	COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,42MVH@68525|delta/epsilon subdivisions,2WMHB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	HJ	Sugar-transfer associated ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST
GDHHQS1_k127_7186415_2	335543.Sfum_1909	3.339e-86	293.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2MQAU@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
GDHHQS1_k127_7186415_0	1304880.JAGB01000002_gene2197	1.505e-302	938.0	COG2407@1|root,COG2407@2|Bacteria,1TQ5Q@1239|Firmicutes,248V0@186801|Clostridia	186801|Clostridia	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
GDHHQS1_k127_7186415_5	1089550.ATTH01000001_gene1358	2.957e-10	72.0	COG0697@1|root,COG0697@2|Bacteria,4PEYF@976|Bacteroidetes,1FJUY@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7186415_3	1210884.HG799468_gene13844	3.504e-57	220.0	COG0585@1|root,COG0585@2|Bacteria,2IWTM@203682|Planctomycetes	203682|Planctomycetes	J	PFAM tRNA pseudouridine synthase D TruD	-	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
GDHHQS1_k127_7186415_1	1453500.AT05_07410	3.109e-127	418.0	COG0436@1|root,COG0436@2|Bacteria,4NG6G@976|Bacteroidetes,1HY78@117743|Flavobacteriia	976|Bacteroidetes	E	Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate	aspC	-	2.6.1.1,2.6.1.2,2.6.1.66	ko:K00812,ko:K14260	ko00220,ko00250,ko00270,ko00290,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00258,R00355,R00694,R00734,R00896,R01215,R02433,R02619,R05052	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS1_k127_7186415_4	1121405.dsmv_0777	3.303e-51	188.0	COG0309@1|root,COG0546@1|root,COG0309@2|Bacteria,COG0546@2|Bacteria,1N04A@1224|Proteobacteria,437IA@68525|delta/epsilon subdivisions,2WYKF@28221|Deltaproteobacteria,2MP0D@213118|Desulfobacterales	28221|Deltaproteobacteria	O	AIR synthase related protein, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
GDHHQS1_k127_7205617_1	1047013.AQSP01000134_gene1371	1.11e-198	642.0	COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2NS54@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	ybaT	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169	-	ko:K07076,ko:K11932,ko:K16263	-	-	-	-	ko00000,ko02000	2.A.3.13	-	-	AA_permease_2,Usp
GDHHQS1_k127_7205617_0	1226325.HMPREF1548_05505	4.317e-246	794.0	COG3250@1|root,COG3250@2|Bacteria,1TS9P@1239|Firmicutes,24C3W@186801|Clostridia,36G7E@31979|Clostridiaceae	186801|Clostridia	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106,Glyco_hydro_2_N
GDHHQS1_k127_7205617_2	1254432.SCE1572_33210	5.891e-167	557.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria,2Z1M7@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
GDHHQS1_k127_7205617_5	28444.JODQ01000004_gene6448	4.151e-17	90.0	COG1486@1|root,COG1486@2|Bacteria,2GK80@201174|Actinobacteria	201174|Actinobacteria	G	family 4	malH	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_7205617_3	234267.Acid_6969	5.019e-151	491.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7205617_6	748449.Halha_2519	1.691e-06	53.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,3WB15@53433|Halanaerobiales	186801|Clostridia	G	PFAM Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_7223240_30	1306990.BARG01000018_gene1846	1.248e-05	47.0	COG1609@1|root,COG1609@2|Bacteria,2GK7G@201174|Actinobacteria	201174|Actinobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
GDHHQS1_k127_7223240_26	1487921.DP68_07280	1.186e-27	121.0	COG1266@1|root,COG1266@2|Bacteria,1VXTB@1239|Firmicutes,24HAI@186801|Clostridia,36J1R@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
GDHHQS1_k127_7223240_6	935948.KE386494_gene530	1.811e-121	414.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,42FSG@68295|Thermoanaerobacterales	186801|Clostridia	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_7223240_7	1191523.MROS_2338	2.313e-113	376.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	ydjG	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0019170,GO:0055114	-	ko:K18471	ko00640,map00640	-	R10718	RC00739	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
GDHHQS1_k127_7223240_18	573413.Spirs_1114	8.326e-59	219.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	nagC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02565,ko:K15545	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR,ROK
GDHHQS1_k127_7223240_28	1042326.AZNV01000029_gene3560	8.298e-15	89.0	2CH5W@1|root,3020J@2|Bacteria,1Q73P@1224|Proteobacteria,2VD7X@28211|Alphaproteobacteria,4BIB8@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7223240_19	272844.PAB1845	4.931e-55	212.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,242X5@183968|Thermococci	183968|Thermococci	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS1_k127_7223240_17	1449126.JQKL01000058_gene2235	2.012e-66	240.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,2682T@186813|unclassified Clostridiales	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
GDHHQS1_k127_7223240_22	1122919.KB905560_gene1455	1.237e-39	170.0	COG3533@1|root,COG3533@2|Bacteria,1VU2F@1239|Firmicutes,4I3KW@91061|Bacilli,26VY6@186822|Paenibacillaceae	91061|Bacilli	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_127
GDHHQS1_k127_7223240_23	580331.Thit_0425	9.103e-37	151.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,42FWJ@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
GDHHQS1_k127_7223240_25	1238450.VIBNISOn1_450025	2.093e-29	128.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,1RYEC@1236|Gammaproteobacteria,1Y25I@135623|Vibrionales	135623|Vibrionales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10238	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	BPD_transp_1
GDHHQS1_k127_7223240_27	478749.BRYFOR_05961	1.27e-17	96.0	COG1653@1|root,COG1653@2|Bacteria,1U4H4@1239|Firmicutes,24A14@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_7223240_5	1121085.AUCI01000006_gene1591	6.258e-135	466.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM_35,CHB_HEX_C_1,Laminin_G_3
GDHHQS1_k127_7223240_9	997884.HMPREF1068_02686	4.536e-106	366.0	COG1520@1|root,COG4225@1|root,COG1520@2|Bacteria,COG4225@2|Bacteria,4NM00@976|Bacteroidetes,2FR1A@200643|Bacteroidia,4ANP9@815|Bacteroidaceae	976|Bacteroidetes	S	unsaturated rhamnogalacturonyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans,Glyco_hydro_88,PQQ_2
GDHHQS1_k127_7223240_13	1121335.Clst_0906	5.836e-84	291.0	COG1082@1|root,COG1082@2|Bacteria,1U81K@1239|Firmicutes,2492P@186801|Clostridia,3WQ0E@541000|Ruminococcaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_7223240_12	382464.ABSI01000013_gene1635	8.405e-95	321.0	COG0667@1|root,COG0667@2|Bacteria,46UF5@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS1_k127_7223240_3	1195236.CTER_1615	9.721e-144	481.0	COG3386@1|root,COG3386@2|Bacteria,1V0DH@1239|Firmicutes,24CIJ@186801|Clostridia	186801|Clostridia	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
GDHHQS1_k127_7223240_1	1304880.JAGB01000002_gene1654	1.633e-167	535.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
GDHHQS1_k127_7223240_0	1499967.BAYZ01000109_gene2986	1.059e-223	702.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_7223240_4	1499967.BAYZ01000118_gene3284	4.021e-140	452.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_7223240_8	649638.Trad_2192	1.796e-110	363.0	COG1028@1|root,COG1028@2|Bacteria,1WJHI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS1_k127_7223240_11	545695.TREAZ_2632	8.061e-97	323.0	COG1028@1|root,COG1028@2|Bacteria,2J7HY@203691|Spirochaetes	203691|Spirochaetes	IQ	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
GDHHQS1_k127_7223240_10	697281.Mahau_0476	1.575e-101	351.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,42ET8@68295|Thermoanaerobacterales	186801|Clostridia	G	Transketolase, central region	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_7223240_14	697281.Mahau_0475	3.799e-82	302.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,42EYC@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
GDHHQS1_k127_7223240_15	889378.Spiaf_1785	1.383e-80	298.0	COG1902@1|root,COG1902@2|Bacteria,2J7Z3@203691|Spirochaetes	203691|Spirochaetes	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
GDHHQS1_k127_7223240_20	744872.Spica_1516	1.157e-54	205.0	2F5GM@1|root,33VRH@2|Bacteria,2JBFA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7223240_29	338966.Ppro_2588	1.137e-09	71.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,43SZA@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM ResB family protein	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
GDHHQS1_k127_7223240_16	545694.TREPR_3192	1.829e-75	276.0	COG0755@1|root,COG0755@2|Bacteria,2JADE@203691|Spirochaetes	203691|Spirochaetes	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
GDHHQS1_k127_7223240_2	744872.Spica_2563	1.276e-161	535.0	COG1032@1|root,COG1032@2|Bacteria,2J656@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7223240_31	604331.AUHY01000038_gene136	0.0002464	51.0	2DGZ3@1|root,2ZXUD@2|Bacteria,1WKRC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
GDHHQS1_k127_7223240_24	1123386.AUIW01000009_gene1812	1.66e-29	122.0	COG1848@1|root,COG1848@2|Bacteria,1WKJ4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7223240_21	266834.SM_b20821	3.933e-44	164.0	COG0413@1|root,COG0413@2|Bacteria,1RFYM@1224|Proteobacteria,2U7V2@28211|Alphaproteobacteria,4BAR4@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Ketopantoate hydroxymethyltransferase	-	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
GDHHQS1_k127_7230517_3	1123274.KB899424_gene2999	1.14e-07	60.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7230517_1	744872.Spica_1490	1.9e-23	103.0	COG1550@1|root,COG1550@2|Bacteria,2J8FX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
GDHHQS1_k127_7230517_2	1047013.AQSP01000033_gene1389	3.795e-22	101.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
GDHHQS1_k127_7238876_0	1304872.JAGC01000003_gene3948	0.0	1444.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria,2M8AX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
GDHHQS1_k127_7238876_4	211165.AJLN01000109_gene163	6.74e-25	121.0	COG0596@1|root,COG0596@2|Bacteria,1G199@1117|Cyanobacteria,1JGYM@1189|Stigonemataceae	1117|Cyanobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
GDHHQS1_k127_7238876_1	1205680.CAKO01000027_gene4745	1.874e-147	480.0	COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria	1224|Proteobacteria	L	PFAM DNA photolyase, FAD-binding	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
GDHHQS1_k127_7238876_3	933262.AXAM01000002_gene504	2.398e-52	204.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_7238876_5	571166.KI421509_gene2632	2.128e-24	118.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,Response_reg,SpoIIE
GDHHQS1_k127_7238876_2	1094980.Mpsy_0812	3.414e-76	280.0	COG3322@1|root,COG3920@1|root,arCOG02335@2157|Archaea,arCOG04446@2157|Archaea,2Y7UT@28890|Euryarchaeota,2NBMR@224756|Methanomicrobia	224756|Methanomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2
GDHHQS1_k127_7238876_6	398767.Glov_0402	2.5e-05	48.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RI33@1224|Proteobacteria,42SUG@68525|delta/epsilon subdivisions,2WP3A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	bamV	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
GDHHQS1_k127_7268126_13	748449.Halha_1052	1.66e-47	181.0	COG0167@1|root,COG1145@1|root,COG0167@2|Bacteria,COG1145@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,3WBGH@53433|Halanaerobiales	186801|Clostridia	C	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4
GDHHQS1_k127_7268126_12	158190.SpiGrapes_0167	6.406e-62	227.0	COG1744@1|root,COG1744@2|Bacteria,2J572@203691|Spirochaetes	203691|Spirochaetes	S	Basic membrane protein	tpn38b	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
GDHHQS1_k127_7268126_1	521045.Kole_1553	9.817e-118	398.0	COG3845@1|root,COG3845@2|Bacteria,2GBZ4@200918|Thermotogae	200918|Thermotogae	S	PFAM ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
GDHHQS1_k127_7268126_9	158190.SpiGrapes_0169	4.109e-74	262.0	COG4603@1|root,COG4603@2|Bacteria,2J7BS@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS1_k127_7268126_7	158190.SpiGrapes_0170	3.706e-81	280.0	COG1079@1|root,COG1079@2|Bacteria,2J81E@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS1_k127_7268126_10	525904.Tter_0410	1.331e-73	268.0	COG2055@1|root,COG2055@2|Bacteria,2NQ9A@2323|unclassified Bacteria	2|Bacteria	C	Malate/L-lactate dehydrogenase	comC	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
GDHHQS1_k127_7268126_11	479434.Sthe_2515	2.238e-64	232.0	COG3836@1|root,COG3836@2|Bacteria,2G925@200795|Chloroflexi,27YE5@189775|Thermomicrobia	189775|Thermomicrobia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
GDHHQS1_k127_7268126_3	158190.SpiGrapes_0167	6.093e-95	326.0	COG1744@1|root,COG1744@2|Bacteria,2J572@203691|Spirochaetes	203691|Spirochaetes	S	Basic membrane protein	tpn38b	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
GDHHQS1_k127_7268126_0	158190.SpiGrapes_0168	3.879e-139	459.0	COG3845@1|root,COG3845@2|Bacteria	2|Bacteria	P	ABC transporter	rbsA	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
GDHHQS1_k127_7268126_5	158190.SpiGrapes_0169	2.521e-89	316.0	COG4603@1|root,COG4603@2|Bacteria,2J7BS@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS1_k127_7268126_6	158190.SpiGrapes_0170	1.924e-87	314.0	COG1079@1|root,COG1079@2|Bacteria,2J81E@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS1_k127_7268126_4	158190.SpiGrapes_0164	2.313e-91	312.0	COG1063@1|root,COG1063@2|Bacteria,2J6S3@203691|Spirochaetes	203691|Spirochaetes	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_7268126_2	158190.SpiGrapes_0165	1.607e-98	343.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_7268126_8	158190.SpiGrapes_0166	1.985e-79	280.0	COG1830@1|root,COG1830@2|Bacteria,2J5HC@203691|Spirochaetes	203691|Spirochaetes	G	PFAM DeoC LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
GDHHQS1_k127_7268126_17	67332.FM21_09715	1.611e-05	57.0	COG0477@1|root,COG2814@2|Bacteria,2GN78@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2.65	-	-	MFS_1
GDHHQS1_k127_7268126_14	671143.DAMO_0380	6.096e-34	132.0	2E3EN@1|root,32YDN@2|Bacteria,2NS2J@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
GDHHQS1_k127_7268126_16	314278.NB231_04355	2.056e-18	89.0	2DQJV@1|root,337C3@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
GDHHQS1_k127_7268126_15	240016.ABIZ01000001_gene4025	1.347e-30	126.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
GDHHQS1_k127_7273765_5	517418.Ctha_0533	8.832e-15	74.0	COG0438@1|root,COG0438@2|Bacteria,1FDQD@1090|Chlorobi	1090|Chlorobi	M	PFAM glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
GDHHQS1_k127_7273765_0	1480694.DC28_12530	5.854e-113	371.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
GDHHQS1_k127_7273765_4	1307761.L21SP2_2351	6.108e-24	106.0	COG1963@1|root,COG1963@2|Bacteria	2|Bacteria	S	Acid phosphatase vanadium-dependent haloperoxidase related	yuiD	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
GDHHQS1_k127_7273765_1	926569.ANT_26620	3.694e-65	230.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS1_k127_7273765_2	573413.Spirs_0334	3.673e-46	181.0	COG2843@1|root,COG2843@2|Bacteria,2J6GA@203691|Spirochaetes	203691|Spirochaetes	M	Bacterial capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
GDHHQS1_k127_7273765_6	744872.Spica_2481	6.473e-05	53.0	2BRF6@1|root,32KE2@2|Bacteria,2J8NK@203691|Spirochaetes	203691|Spirochaetes	M	Domain of unknown function (DUF4398)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
GDHHQS1_k127_7273765_3	889378.Spiaf_1719	8.989e-27	116.0	COG0457@1|root,COG0457@2|Bacteria,2JAI6@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7318386_1	1120950.KB892756_gene6655	7.264e-20	103.0	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,4DSTX@85009|Propionibacteriales	201174|Actinobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	galE	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
GDHHQS1_k127_7318386_0	312284.A20C1_08378	2.452e-31	142.0	2F006@1|root,33T46@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7353647_2	1541065.JRFE01000025_gene1965	1.932e-79	276.0	COG1397@1|root,COG1397@2|Bacteria,1G437@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM ADP-ribosylglycohydrolase	-	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
GDHHQS1_k127_7353647_5	479434.Sthe_2603	1.192e-25	121.0	COG3595@1|root,COG3595@2|Bacteria,2G73J@200795|Chloroflexi	200795|Chloroflexi	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
GDHHQS1_k127_7353647_3	309798.COPRO5265_0008	3.799e-61	219.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,42G5Q@68295|Thermoanaerobacterales	186801|Clostridia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
GDHHQS1_k127_7353647_0	1347087.CBYO010000022_gene3297	7.158e-147	481.0	COG0477@1|root,COG0477@2|Bacteria,1UHRM@1239|Firmicutes,4ISTP@91061|Bacilli	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
GDHHQS1_k127_7353647_4	1519439.JPJG01000031_gene1729	4.536e-30	136.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,2N6UP@216572|Oscillospiraceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
GDHHQS1_k127_7353647_1	518766.Rmar_1623	3.437e-87	294.0	COG3291@1|root,COG3291@2|Bacteria,4PMYH@976|Bacteroidetes	976|Bacteroidetes	S	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
GDHHQS1_k127_7379386_1	665571.STHERM_c15900	1.21e-57	210.0	COG0118@1|root,COG0118@2|Bacteria,2J8MS@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
GDHHQS1_k127_7379386_0	665571.STHERM_c15890	5.108e-117	385.0	COG0107@1|root,COG0107@2|Bacteria,2J6FB@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
GDHHQS1_k127_7379386_2	573413.Spirs_1898	1.067e-19	102.0	COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes	203691|Spirochaetes	S	FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
GDHHQS1_k127_7394646_0	459349.CLOAM1211	3.265e-196	618.0	COG0205@1|root,COG0205@2|Bacteria,2NP3J@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
GDHHQS1_k127_7394646_1	744872.Spica_0812	1.728e-98	333.0	COG5608@1|root,COG5608@2|Bacteria,2J9FY@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Late embryogenesis abundant protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
GDHHQS1_k127_7394646_2	644282.Deba_2986	1.926e-38	150.0	COG0095@1|root,COG0095@2|Bacteria,1RDZE@1224|Proteobacteria	1224|Proteobacteria	H	PFAM biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
GDHHQS1_k127_7415955_2	1499967.BAYZ01000066_gene6056	3.981e-34	148.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_7415955_1	1499967.BAYZ01000118_gene3283	1.212e-120	402.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_7415955_0	1499967.BAYZ01000159_gene504	1.473e-147	474.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	1.1.1.370	ko:K16043	ko00562,ko01120,map00562,map01120	-	R09953	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_7415955_3	445971.ANASTE_00826	1.79e-11	68.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,25ZNZ@186806|Eubacteriaceae	186801|Clostridia	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
GDHHQS1_k127_74202_65	1536774.H70357_17705	4.335e-09	58.0	COG0395@1|root,COG0395@2|Bacteria,1TPHS@1239|Firmicutes,4HF83@91061|Bacilli,26RB4@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	lplC9	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_74202_4	1499967.BAYZ01000131_gene362	2.907e-219	691.0	COG2407@1|root,COG2407@2|Bacteria	2|Bacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
GDHHQS1_k127_74202_3	1499967.BAYZ01000159_gene498	8.968e-238	766.0	COG1069@1|root,COG1069@2|Bacteria,2NQNS@2323|unclassified Bacteria	2|Bacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	araB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008741,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046373,GO:0046835,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100	-	R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000	-	-	iBWG_1329.BWG_0059,iECH74115_1262.ECH74115_0068,iECSP_1301.ECSP_0067,iECs_1301.ECs0067,iG2583_1286.G2583_0066,iPC815.YPO2254,iZ_1308.Z0072	FGGY_C,FGGY_N
GDHHQS1_k127_74202_33	709991.Odosp_0034	3.068e-79	279.0	COG0235@1|root,COG0235@2|Bacteria,4NGMP@976|Bacteroidetes,2FMV0@200643|Bacteroidia,22WKM@171551|Porphyromonadaceae	976|Bacteroidetes	G	Class II Aldolase and Adducin N-terminal domain	araD	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
GDHHQS1_k127_74202_47	368408.Tpen_0319	9.651e-43	178.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
GDHHQS1_k127_74202_52	1408419.JHYG01000004_gene1437	6.858e-37	149.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TZJG@28211|Alphaproteobacteria,2JQDD@204441|Rhodospirillales	204441|Rhodospirillales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,MASE1,Response_reg
GDHHQS1_k127_74202_21	1499967.BAYZ01000076_gene841	6.399e-105	352.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
GDHHQS1_k127_74202_66	1123274.KB899409_gene466	7.846e-09	63.0	28Y5G@1|root,2ZK0U@2|Bacteria,2JB1C@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_30	1121935.AQXX01000118_gene4933	9.221e-82	287.0	COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria,1RXGJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von willebrand factor, type A	-	-	2.7.11.1	ko:K11912	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	VWA_2
GDHHQS1_k127_74202_5	1313421.JHBV01000041_gene3629	1.183e-168	558.0	COG2304@1|root,COG2304@2|Bacteria,4NK2W@976|Bacteroidetes	976|Bacteroidetes	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	OmpA,VIT,VWA,VWA_3
GDHHQS1_k127_74202_40	378806.STAUR_6673	3.767e-66	242.0	COG5459@1|root,COG5459@2|Bacteria,1MWMM@1224|Proteobacteria,42WIB@68525|delta/epsilon subdivisions,2WRHR@28221|Deltaproteobacteria,2YZNU@29|Myxococcales	28221|Deltaproteobacteria	J	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
GDHHQS1_k127_74202_6	1499967.BAYZ01000155_gene633	8.313e-152	503.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_74202_48	706587.Desti_4300	3.328e-42	167.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
GDHHQS1_k127_74202_38	1041138.KB890221_gene1420	1.059e-70	250.0	COG1830@1|root,COG1830@2|Bacteria,1N4VG@1224|Proteobacteria,2UE4V@28211|Alphaproteobacteria,4BCMB@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
GDHHQS1_k127_74202_39	478741.JAFS01000001_gene1978	3.074e-67	238.0	COG2360@1|root,COG2360@2|Bacteria,46VHR@74201|Verrucomicrobia,37GDI@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
GDHHQS1_k127_74202_60	158189.SpiBuddy_2752	5.132e-18	99.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
GDHHQS1_k127_74202_31	744872.Spica_1887	4.94e-80	293.0	COG0477@1|root,COG2814@2|Bacteria,2JAJU@203691|Spirochaetes	203691|Spirochaetes	EGP	Major Facilitator Superfamily	-	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1
GDHHQS1_k127_74202_0	665571.STHERM_c12610	9.921e-284	891.0	COG0542@1|root,COG0542@2|Bacteria,2J6BU@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
GDHHQS1_k127_74202_56	56780.SYN_02377	1.198e-27	118.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MS9E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
GDHHQS1_k127_74202_64	103733.JNYO01000070_gene3646	2.201e-09	70.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4E8XQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
GDHHQS1_k127_74202_25	889378.Spiaf_1081	1.331e-93	325.0	COG1624@1|root,COG1762@1|root,COG1624@2|Bacteria,COG1762@2|Bacteria,2J84N@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
GDHHQS1_k127_74202_43	573413.Spirs_3787	1.059e-59	232.0	COG2114@1|root,COG2114@2|Bacteria,2J9VX@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_51	1123274.KB899410_gene3503	2.426e-37	153.0	COG2114@1|root,COG2114@2|Bacteria,2JAZ7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_16	1089548.KI783301_gene3181	3.562e-115	382.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,3WE9Q@539002|Bacillales incertae sedis	91061|Bacilli	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
GDHHQS1_k127_74202_55	399742.Ent638_1957	2.421e-29	130.0	COG0451@1|root,COG0451@2|Bacteria,1R4XX@1224|Proteobacteria	1224|Proteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.203	ko:K18981	ko00053,map00053	-	R10841	RC00066	ko00000,ko00001,ko01000	-	-	-	Epimerase
GDHHQS1_k127_74202_36	660470.Theba_0067	1.082e-75	267.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_74202_69	316067.Geob_2542	9.392e-07	61.0	COG0407@1|root,COG0407@2|Bacteria,1MZ5P@1224|Proteobacteria,42TMK@68525|delta/epsilon subdivisions,2WR32@28221|Deltaproteobacteria,43UTT@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_74202_2	556261.HMPREF0240_00421	4.482e-243	782.0	COG1882@1|root,COG1882@2|Bacteria,1VTIM@1239|Firmicutes,24EPG@186801|Clostridia,36H8K@31979|Clostridiaceae	186801|Clostridia	C	Pyruvate formate lyase-like	-	-	-	-	-	-	-	-	-	-	-	-	Gly_radical,PFL-like
GDHHQS1_k127_74202_63	1121346.KB899813_gene2189	2.109e-09	70.0	2BNNR@1|root,32HBR@2|Bacteria,1W3MN@1239|Firmicutes,4I0RU@91061|Bacilli,273QC@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_11	1280390.CBQR020000071_gene1442	5.091e-140	466.0	2DBD9@1|root,2Z8J6@2|Bacteria,1V9NP@1239|Firmicutes,4HQDX@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_59	1270193.JARP01000004_gene1414	4.082e-19	104.0	28IIY@1|root,2Z8JY@2|Bacteria,4NHQ5@976|Bacteroidetes,1IMWR@117743|Flavobacteriia,2NVU8@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_67	545695.TREAZ_2899	3.103e-08	64.0	28MXM@1|root,2Z8AT@2|Bacteria,2JBFX@203691|Spirochaetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_54	1123075.AUDP01000024_gene1065	1.011e-31	140.0	28MXM@1|root,2Z8AT@2|Bacteria,1V0XI@1239|Firmicutes,24DIS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_18	1089548.KI783301_gene819	9.061e-111	373.0	2DBD9@1|root,2Z8J6@2|Bacteria,1V9NP@1239|Firmicutes,4HQDX@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_7	697281.Mahau_2288	1.806e-150	484.0	COG0407@1|root,COG0407@2|Bacteria,1UZSW@1239|Firmicutes,24E13@186801|Clostridia	697281.Mahau_2288|-	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_46	1117108.PAALTS15_24580	5.001e-44	177.0	COG1653@1|root,COG1653@2|Bacteria,1V96Q@1239|Firmicutes,4IRIF@91061|Bacilli,276SS@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
GDHHQS1_k127_74202_61	1122963.AUHB01000001_gene588	7.124e-17	95.0	28IIY@1|root,2Z8JY@2|Bacteria,1NRU9@1224|Proteobacteria,2UPN0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_32	1304880.JAGB01000001_gene434	1.151e-79	278.0	COG0395@1|root,COG0395@2|Bacteria,1UYH5@1239|Firmicutes,24AMA@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_74202_37	697281.Mahau_0463	2.957e-71	251.0	COG1175@1|root,COG1175@2|Bacteria,1U73Q@1239|Firmicutes,24AFP@186801|Clostridia,42I87@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_74202_15	1304880.JAGB01000001_gene436	1.477e-116	419.0	COG3420@1|root,COG3420@2|Bacteria,1TSNZ@1239|Firmicutes,24D4T@186801|Clostridia	186801|Clostridia	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_9	697281.Mahau_0458	2.402e-140	475.0	COG0457@1|root,COG2881@1|root,COG3391@1|root,COG0457@2|Bacteria,COG2881@2|Bacteria,COG3391@2|Bacteria,1U3IC@1239|Firmicutes,2490J@186801|Clostridia,42I05@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,Yip1
GDHHQS1_k127_74202_27	717605.Theco_2273	3.178e-92	327.0	COG0395@1|root,COG0395@2|Bacteria,1TRS1@1239|Firmicutes,4HFCC@91061|Bacilli,26U82@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_74202_20	1122917.KB899675_gene246	5.06e-108	358.0	COG1175@1|root,COG1175@2|Bacteria,1TR0M@1239|Firmicutes,4HC8B@91061|Bacilli,26TEK@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_74202_1	1304880.JAGB01000001_gene440	6.333e-250	821.0	COG1653@1|root,COG1653@2|Bacteria,1UYEE@1239|Firmicutes,24B6R@186801|Clostridia	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_74202_13	661478.OP10G_4566	6.795e-129	446.0	2DBD9@1|root,2Z8J6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_41	1480694.DC28_15120	1.198e-65	237.0	COG1609@1|root,COG1609@2|Bacteria,2J87T@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
GDHHQS1_k127_74202_34	1195236.CTER_1271	2.316e-78	287.0	2C4GI@1|root,2Z7IK@2|Bacteria,1TR77@1239|Firmicutes,24DI3@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1861)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1861
GDHHQS1_k127_74202_58	1449355.JQNR01000005_gene4872	6.697e-26	124.0	COG2152@1|root,COG3537@1|root,COG2152@2|Bacteria,COG3537@2|Bacteria,2I57U@201174|Actinobacteria	201174|Actinobacteria	G	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_49	1254432.SCE1572_39530	1.784e-39	159.0	COG3173@1|root,COG3173@2|Bacteria,1R5VZ@1224|Proteobacteria	1224|Proteobacteria	S	Phosphotransferase enzyme family	-	-	2.7.1.119	ko:K17880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	APH
GDHHQS1_k127_74202_44	697281.Mahau_0767	1.138e-55	214.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24IZV@186801|Clostridia,42J2I@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_74202_57	1358423.N180_08650	1.721e-26	127.0	28IIY@1|root,2Z8JY@2|Bacteria,4NHQ5@976|Bacteroidetes,1IQVD@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_35	180332.JTGN01000003_gene2001	1.616e-76	282.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_74202_24	697281.Mahau_1771	1.746e-97	331.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_74202_23	180332.JTGN01000006_gene3443	2.511e-100	346.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes	1239|Firmicutes	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_74202_42	794903.OPIT5_11270	6.916e-60	220.0	COG1082@1|root,COG1082@2|Bacteria,46UG0@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_74202_17	556261.HMPREF0240_00139	1.225e-112	376.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_74202_26	180332.JTGN01000003_gene2001	2.095e-92	319.0	COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24E5A@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_74202_45	266117.Rxyl_1235	1.835e-51	208.0	COG3119@1|root,COG3119@2|Bacteria,2H50Z@201174|Actinobacteria,4CRT6@84995|Rubrobacteria	84995|Rubrobacteria	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
GDHHQS1_k127_74202_68	643648.Slip_0763	1.536e-07	64.0	COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,249D0@186801|Clostridia,42KCD@68298|Syntrophomonadaceae	186801|Clostridia	G	SPTR Q0AVN8 Glycosylase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
GDHHQS1_k127_74202_8	390874.Tpet_0865	6.144e-141	457.0	COG1173@1|root,COG1173@2|Bacteria,2GCBY@200918|Thermotogae	200918|Thermotogae	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
GDHHQS1_k127_74202_22	706587.Desti_5628	8.918e-103	344.0	COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,2MQBC@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS1_k127_74202_19	1219084.AP014508_gene1004	4.313e-108	374.0	COG0747@1|root,COG0747@2|Bacteria,2GCNZ@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS1_k127_74202_10	697281.Mahau_1202	4.553e-140	454.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,42F38@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_74202_14	1304880.JAGB01000002_gene2307	1.043e-117	399.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS1_k127_74202_12	485913.Krac_1042	5.663e-135	439.0	COG2152@1|root,COG2152@2|Bacteria,2G6ZE@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycosidase PH1107-related	-	-	2.4.1.319,2.4.1.320,2.4.1.339,2.4.1.340	ko:K18785,ko:K20885	-	-	R10811,R10829,R11397,R11398	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
GDHHQS1_k127_74202_29	278957.ABEA03000166_gene4032	2.337e-85	307.0	COG0407@1|root,COG0407@2|Bacteria,46UQR@74201|Verrucomicrobia,3K9WM@414999|Opitutae	414999|Opitutae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_74202_53	66692.ABC3582	6.405e-32	143.0	COG0644@1|root,COG0644@2|Bacteria,1TR0D@1239|Firmicutes,4HBWH@91061|Bacilli,1ZDCV@1386|Bacillus	91061|Bacilli	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
GDHHQS1_k127_74202_50	1120972.AUMH01000004_gene1436	2.513e-39	167.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	2.4.1.339,2.4.1.340,3.2.1.197	ko:K20885,ko:K21065	-	-	R11397,R11398,R11544	RC00049,RC02748	ko00000,ko01000	-	GH130	-	Glyco_hydro_130
GDHHQS1_k127_74202_28	449673.BACSTE_02588	2.118e-87	319.0	28KZC@1|root,2ZAEP@2|Bacteria,4NITB@976|Bacteroidetes,2FX9E@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_74202_62	1461694.ATO9_09530	6.939e-11	71.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2V8RX@28211|Alphaproteobacteria,2PFPW@252301|Oceanicola	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_7459626_3	926554.KI912674_gene2548	1.529e-23	114.0	COG0845@1|root,COG0845@2|Bacteria,1WJ9T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
GDHHQS1_k127_7459626_0	264462.Bd0709	3.223e-174	570.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2MTI3@213481|Bdellovibrionales,2X727@28221|Deltaproteobacteria	213481|Bdellovibrionales	V	membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
GDHHQS1_k127_7459626_2	744872.Spica_0733	4.541e-77	264.0	COG0745@1|root,COG0745@2|Bacteria,2J7CF@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS1_k127_7459626_1	744872.Spica_0734	6.611e-82	288.0	COG0642@1|root,COG2205@2|Bacteria,2J63U@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS1_k127_7462257_2	530564.Psta_3315	5.39e-44	178.0	COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,2IXQA@203682|Planctomycetes	203682|Planctomycetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,PAS_4,PAS_9
GDHHQS1_k127_7462257_1	760568.Desku_2036	2.223e-62	244.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9,Response_reg,dCache_3,sCache_3_3
GDHHQS1_k127_7462257_0	1123274.KB899410_gene3363	1.273e-85	319.0	COG2911@1|root,COG2911@2|Bacteria,2J6UE@203691|Spirochaetes	203691|Spirochaetes	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig
GDHHQS1_k127_7462257_3	717773.Thicy_0285	2.824e-17	98.0	COG3087@1|root,COG3210@1|root,COG3087@2|Bacteria,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,1RSAX@1236|Gammaproteobacteria,461F5@72273|Thiotrichales	72273|Thiotrichales	U	Large exoproteins involved in heme utilization or adhesion	-	-	-	-	-	-	-	-	-	-	-	-	PATR
GDHHQS1_k127_749697_2	926550.CLDAP_24220	7.781e-69	238.0	28JDC@1|root,2Z97R@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
GDHHQS1_k127_749697_3	744872.Spica_0661	4.727e-12	74.0	2ANXJ@1|root,31DYA@2|Bacteria,2JB64@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_749697_1	665571.STHERM_c10350	3.038e-81	280.0	COG0157@1|root,COG0157@2|Bacteria,2J93N@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767,ko:K03813	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
GDHHQS1_k127_749697_0	1307761.L21SP2_1446	4.008e-131	429.0	COG0029@1|root,COG0029@2|Bacteria,2JBD7@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
GDHHQS1_k127_7547783_9	1123355.JHYO01000018_gene1667	1.253e-05	53.0	COG1366@1|root,COG1366@2|Bacteria,1NGGT@1224|Proteobacteria,2UHDV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
GDHHQS1_k127_7547783_7	926560.KE387023_gene1958	6.385e-18	90.0	2DRNI@1|root,33CD9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7547783_8	203119.Cthe_0073	4.351e-09	66.0	COG4758@1|root,COG4758@2|Bacteria,1UITP@1239|Firmicutes,24NAQ@186801|Clostridia	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
GDHHQS1_k127_7547783_1	1191523.MROS_2798	5.189e-147	494.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
GDHHQS1_k127_7547783_0	335543.Sfum_3244	2.243e-199	627.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
GDHHQS1_k127_7547783_4	357808.RoseRS_3316	3.268e-44	176.0	COG0483@1|root,COG0483@2|Bacteria,2G6JD@200795|Chloroflexi,375ER@32061|Chloroflexia	32061|Chloroflexia	G	PFAM inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
GDHHQS1_k127_7547783_5	697281.Mahau_1532	3.646e-30	137.0	COG5012@1|root,COG5012@2|Bacteria,1V82H@1239|Firmicutes,24JSA@186801|Clostridia	186801|Clostridia	S	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7547783_6	373903.Hore_12950	1.884e-25	119.0	COG0407@1|root,COG0407@2|Bacteria,1V7NA@1239|Firmicutes,24MGR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7547783_3	926569.ANT_14890	1.625e-50	194.0	COG2267@1|root,COG2267@2|Bacteria,2G6QC@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
GDHHQS1_k127_7547783_2	926569.ANT_29670	1.509e-64	249.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_7657_1	545694.TREPR_2639	1.212e-172	571.0	COG1643@1|root,COG1643@2|Bacteria,2J62C@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
GDHHQS1_k127_7657_4	1480694.DC28_03360	1.23e-78	283.0	COG1315@1|root,COG1315@2|Bacteria,2J6E5@203691|Spirochaetes	203691|Spirochaetes	L	Pfam:DUF342	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
GDHHQS1_k127_7657_6	889378.Spiaf_2305	5.506e-30	123.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K03413,ko:K21993	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035	1.A.16.2	-	-	Form_Nir_trans,HATPase_c,HTH_8,HisKA,Response_reg
GDHHQS1_k127_7657_5	1267535.KB906767_gene1217	4.473e-66	245.0	COG4974@1|root,COG4974@2|Bacteria,3Y6KW@57723|Acidobacteria	57723|Acidobacteria	L	phage integrase domain protein SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_7657_3	381666.PHG042	1.175e-157	509.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,2VMS7@28216|Betaproteobacteria,1JZVB@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_7657_2	76114.p2A228	8.235e-158	501.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2VJRU@28216|Betaproteobacteria,2KXTA@206389|Rhodocyclales	206389|Rhodocyclales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
GDHHQS1_k127_7657_0	381666.PHG038	2.429e-173	548.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria,1K65J@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_7657_7	266264.Rmet_1273	1.236e-29	119.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria,1K65J@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS1_k127_7657_8	927677.ALVU02000005_gene547	2.5e-24	105.0	COG5433@1|root,COG5433@2|Bacteria,1G2IT@1117|Cyanobacteria	1117|Cyanobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
GDHHQS1_k127_7718683_2	1121468.AUBR01000033_gene1208	1.161e-46	187.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,42EU1@68295|Thermoanaerobacterales	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS1_k127_7718683_3	925409.KI911562_gene374	1.848e-10	72.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
GDHHQS1_k127_7718683_4	502025.Hoch_4790	5.645e-09	68.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YYCB@29|Myxococcales	28221|Deltaproteobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
GDHHQS1_k127_7718683_1	1120973.AQXL01000124_gene2358	4.775e-61	233.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,279HQ@186823|Alicyclobacillaceae	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS1_k127_7718683_0	1304880.JAGB01000002_gene1773	1.734e-276	868.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia	186801|Clostridia	G	beta-galactosidase	pbg	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
GDHHQS1_k127_7722193_3	525897.Dbac_2314	7.533e-57	216.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,2MB0D@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Pyruvate ketoisovalerate oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
GDHHQS1_k127_7722193_1	891968.Anamo_1440	7.074e-249	788.0	COG4231@1|root,COG4231@2|Bacteria,3T9PR@508458|Synergistetes	508458|Synergistetes	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
GDHHQS1_k127_7722193_4	1125699.HMPREF9194_02175	3.272e-49	203.0	2FEVZ@1|root,346UT@2|Bacteria,2J9B6@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7722193_5	1379698.RBG1_1C00001G0936	2.527e-32	136.0	COG1335@1|root,COG1335@2|Bacteria,2NRGH@2323|unclassified Bacteria	2|Bacteria	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
GDHHQS1_k127_7722193_2	1480694.DC28_11295	4.694e-162	519.0	COG1816@1|root,COG1816@2|Bacteria	2|Bacteria	F	deaminase activity	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
GDHHQS1_k127_7722193_0	545695.TREAZ_2148	2.783e-270	865.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
GDHHQS1_k127_7722193_6	880072.Desac_2411	0.0001971	53.0	COG0642@1|root,COG2203@1|root,COG3605@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3605@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,MASE1,PAS,PAS_4,PAS_9,Response_reg
GDHHQS1_k127_7762234_3	1499967.BAYZ01000104_gene3700	1.289e-41	170.0	COG1082@1|root,COG3291@1|root,COG1082@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,UnbV_ASPIC,VCBS
GDHHQS1_k127_7762234_4	556261.HMPREF0240_03601	8.929e-10	70.0	COG0407@1|root,COG0407@2|Bacteria,1TS5A@1239|Firmicutes,24F2K@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7762234_1	180332.JTGN01000005_gene2898	3.92e-68	250.0	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
GDHHQS1_k127_7762234_0	471854.Dfer_1569	1.479e-251	807.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,47MY0@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
GDHHQS1_k127_7762234_2	1122917.KB899667_gene3723	4.296e-67	232.0	COG0395@1|root,COG0395@2|Bacteria,1TPHS@1239|Firmicutes,4HF83@91061|Bacilli,26RB4@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_7779474_26	1121472.AQWN01000005_gene2341	4.722e-07	61.0	COG1566@1|root,COG1566@2|Bacteria,1TRB8@1239|Firmicutes,24AG7@186801|Clostridia,261CA@186807|Peptococcaceae	186801|Clostridia	V	Secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
GDHHQS1_k127_7779474_25	661478.OP10G_0769	1.682e-08	67.0	COG1538@1|root,COG1538@2|Bacteria	661478.OP10G_0769|-	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7779474_22	1125700.HMPREF9195_01154	4.13e-13	78.0	2CK8S@1|root,2ZY01@2|Bacteria,2J87W@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7779474_14	1196323.ALKF01000201_gene2936	9.573e-47	182.0	COG0500@1|root,COG2226@2|Bacteria,1V0UT@1239|Firmicutes,4IT1S@91061|Bacilli,2777J@186822|Paenibacillaceae	91061|Bacilli	Q	sAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
GDHHQS1_k127_7779474_13	138119.DSY2870	4.749e-50	192.0	COG1082@1|root,COG1082@2|Bacteria,1UZFB@1239|Firmicutes,247UI@186801|Clostridia,2641T@186807|Peptococcaceae	186801|Clostridia	G	Sugar phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
GDHHQS1_k127_7779474_23	661478.OP10G_1929	4.626e-13	77.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_7779474_16	32057.KB217478_gene5882	1.163e-40	156.0	COG5533@1|root,COG5533@2|Bacteria,1G67R@1117|Cyanobacteria,1HSQW@1161|Nostocales	1117|Cyanobacteria	O	Opioid growth factor receptor (OGFr) conserved region	-	-	-	-	-	-	-	-	-	-	-	-	OGFr_N
GDHHQS1_k127_7779474_8	545695.TREAZ_0221	7.135e-87	299.0	COG0191@1|root,COG0191@2|Bacteria,2J9U8@203691|Spirochaetes	203691|Spirochaetes	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
GDHHQS1_k127_7779474_5	1303518.CCALI_00386	8.221e-105	363.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_7779474_4	158189.SpiBuddy_2223	1.665e-116	412.0	COG0613@1|root,COG0613@2|Bacteria,2J6D0@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7779474_6	926550.CLDAP_03280	4.195e-103	343.0	COG1957@1|root,COG1957@2|Bacteria,2G7IF@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Inosine uridine-preferring nucleoside hydrolase	-	-	3.2.2.1	ko:K01239	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
GDHHQS1_k127_7779474_24	373994.Riv7116_1768	6.994e-09	66.0	2CBRD@1|root,32RTX@2|Bacteria,1G64U@1117|Cyanobacteria,1HQ69@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7779474_2	1304880.JAGB01000002_gene1624	1.959e-193	619.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7779474_10	66429.JOFL01000003_gene3295	1.469e-66	237.0	COG0584@1|root,COG0584@2|Bacteria,2GIY5@201174|Actinobacteria	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	GDPD_2
GDHHQS1_k127_7779474_19	744872.Spica_2481	2.367e-22	113.0	2BRF6@1|root,32KE2@2|Bacteria,2J8NK@203691|Spirochaetes	203691|Spirochaetes	M	Domain of unknown function (DUF4398)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
GDHHQS1_k127_7779474_9	1123274.KB899410_gene3492	8.543e-67	259.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
GDHHQS1_k127_7779474_3	744872.Spica_2479	2.416e-121	401.0	2AMMU@1|root,31CHX@2|Bacteria,2J7FZ@203691|Spirochaetes	203691|Spirochaetes	S	by glimmer	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7779474_18	397948.Cmaq_1276	2.202e-31	143.0	COG4354@1|root,arCOG03865@2157|Archaea,2XRKN@28889|Crenarchaeota	28889|Crenarchaeota	G	beta-glucosidase 2, glycosyl-hydrolase family 116 N-term	-	-	-	-	-	-	-	-	-	-	-	-	DUF608,Glyco_hydr_116N
GDHHQS1_k127_7779474_7	545694.TREPR_2780	2.511e-87	316.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7779474_17	459349.CLOAM0425	1.55e-38	157.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,2NQWH@2323|unclassified Bacteria	2|Bacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Pkinase,Trypsin_2
GDHHQS1_k127_7779474_1	1499967.BAYZ01000131_gene368	7.15e-209	673.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2NP16@2323|unclassified Bacteria	2|Bacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
GDHHQS1_k127_7779474_11	1499967.BAYZ01000131_gene367	6.707e-61	228.0	COG4783@1|root,COG4783@2|Bacteria,2NP4F@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
GDHHQS1_k127_7779474_20	1304872.JAGC01000009_gene116	3.976e-22	107.0	COG3807@1|root,COG3807@2|Bacteria,1N5AB@1224|Proteobacteria,42URU@68525|delta/epsilon subdivisions,2WQYJ@28221|Deltaproteobacteria,2MBA2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Bacterial SH3 domain homologues	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
GDHHQS1_k127_7779474_0	889378.Spiaf_2634	6.598e-253	796.0	COG0326@1|root,COG0326@2|Bacteria,2J6JQ@203691|Spirochaetes	203691|Spirochaetes	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
GDHHQS1_k127_7779474_12	929703.KE386491_gene3023	8.644e-54	199.0	COG1030@1|root,COG1030@2|Bacteria,4PN0T@976|Bacteroidetes,47YFF@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
GDHHQS1_k127_7779474_15	545695.TREAZ_3287	4.72e-44	167.0	COG0618@1|root,COG0618@2|Bacteria,2J6ZI@203691|Spirochaetes	203691|Spirochaetes	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH
GDHHQS1_k127_7803130_1	573413.Spirs_3991	1.054e-90	318.0	COG0857@1|root,COG0857@2|Bacteria	2|Bacteria	C	belongs to the CobB CobQ family	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
GDHHQS1_k127_7803130_0	889378.Spiaf_1894	6.017e-182	578.0	COG0119@1|root,COG0119@2|Bacteria,2J6AF@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
GDHHQS1_k127_7803164_0	697281.Mahau_0015	1.28e-315	992.0	COG0383@1|root,COG0383@2|Bacteria,1V0Q3@1239|Firmicutes,24AMV@186801|Clostridia,42I1U@68295|Thermoanaerobacterales	186801|Clostridia	G	Alpha mannosidase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
GDHHQS1_k127_7803164_8	309801.trd_1946	1.066e-98	332.0	COG3386@1|root,COG3386@2|Bacteria,2GBCX@200795|Chloroflexi,27YTS@189775|Thermomicrobia	189775|Thermomicrobia	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
GDHHQS1_k127_7803164_15	545695.TREAZ_2759	1.764e-47	190.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7803164_17	889378.Spiaf_2195	3.201e-35	144.0	2EEHS@1|root,338BM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7803164_3	211165.AJLN01000017_gene2137	4.609e-195	627.0	COG2217@1|root,COG2217@2|Bacteria,1G11M@1117|Cyanobacteria,1JJQ5@1189|Stigonemataceae	1117|Cyanobacteria	P	E1-E2 ATPase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
GDHHQS1_k127_7803164_18	1278306.KB906922_gene1761	3.31e-20	94.0	COG0640@1|root,COG0640@2|Bacteria,37A93@32066|Fusobacteria	32066|Fusobacteria	K	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
GDHHQS1_k127_7803164_19	349161.Dred_2977	5.185e-14	81.0	COG3212@1|root,COG3212@2|Bacteria,1VJGF@1239|Firmicutes,24RQ9@186801|Clostridia,262RI@186807|Peptococcaceae	186801|Clostridia	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7803164_23	1379281.AVAG01000045_gene368	7.765e-05	49.0	COG3462@1|root,COG3462@2|Bacteria,1QE33@1224|Proteobacteria,43EKD@68525|delta/epsilon subdivisions,2X0Z4@28221|Deltaproteobacteria,2MDTR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
GDHHQS1_k127_7803164_14	158190.SpiGrapes_2635	2.334e-63	226.0	COG0745@1|root,COG0745@2|Bacteria,2J7YW@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulatory protein	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS1_k127_7803164_12	158190.SpiGrapes_2634	1.58e-76	283.0	COG0642@1|root,COG2205@2|Bacteria,2J7ZP@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS1_k127_7803164_20	158190.SpiGrapes_3226	1.018e-13	74.0	2EMZY@1|root,33FN4@2|Bacteria,2J8Y2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7803164_16	309799.DICTH_1530	2.574e-37	147.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Nitroreductase
GDHHQS1_k127_7803164_2	697281.Mahau_1207	6.357e-198	634.0	COG2730@1|root,COG2730@2|Bacteria,1V9GI@1239|Firmicutes,24KYA@186801|Clostridia	186801|Clostridia	G	Domain of unknown function (DUF5060)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4038,DUF5060
GDHHQS1_k127_7803164_7	697281.Mahau_1209	3.427e-153	509.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7803164_24	478741.JAFS01000002_gene184	0.0004408	52.0	2BFNX@1|root,329HD@2|Bacteria,46ZC6@74201|Verrucomicrobia,37GSZ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7803164_5	290397.Adeh_3930	5.625e-168	541.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2YXS2@29|Myxococcales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
GDHHQS1_k127_7803164_13	552811.Dehly_0392	6.069e-75	283.0	COG0383@1|root,COG0383@2|Bacteria,2G5U7@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
GDHHQS1_k127_7803164_9	1480694.DC28_07030	2.775e-95	330.0	COG0544@1|root,COG0544@2|Bacteria,2J5FS@203691|Spirochaetes	203691|Spirochaetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
GDHHQS1_k127_7803164_10	665571.STHERM_c05830	2.958e-95	316.0	COG0740@1|root,COG0740@2|Bacteria,2J5VY@203691|Spirochaetes	203691|Spirochaetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
GDHHQS1_k127_7803164_4	1123274.KB899417_gene2164	4.36e-189	598.0	COG1219@1|root,COG1219@2|Bacteria,2J5FF@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
GDHHQS1_k127_7803164_1	573413.Spirs_1293	2.733e-264	847.0	COG0466@1|root,COG0466@2|Bacteria,2J71Y@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
GDHHQS1_k127_7803164_11	935948.KE386495_gene1239	2.188e-82	287.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7803164_6	589865.DaAHT2_1713	1.571e-161	520.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,2MJ3W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
GDHHQS1_k127_7812244_12	28532.XP_010543611.1	6.764e-06	51.0	COG0531@1|root,KOG1286@2759|Eukaryota,37INT@33090|Viridiplantae,3GE9C@35493|Streptophyta,3HSB2@3699|Brassicales	35493|Streptophyta	E	Cationic amino acid transporter 9	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0009507,GO:0009526,GO:0009536,GO:0009941,GO:0016020,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0042170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0098588,GO:0098805	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
GDHHQS1_k127_7812244_10	1162668.LFE_0693	9.113e-23	109.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
GDHHQS1_k127_7812244_11	589873.EP13_11740	3.41e-22	110.0	28KJN@1|root,2ZA4P@2|Bacteria,1NU5W@1224|Proteobacteria,1SK99@1236|Gammaproteobacteria,46CDW@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7812244_9	926556.Echvi_0410	1.466e-53	198.0	COG2188@1|root,COG2188@2|Bacteria,4PJQ8@976|Bacteroidetes,47PR4@768503|Cytophagia	976|Bacteroidetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
GDHHQS1_k127_7812244_3	1238450.VIBNISOn1_280037	4.491e-105	349.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria,1Y26H@135623|Vibrionales	1224|Proteobacteria	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
GDHHQS1_k127_7812244_1	1238450.VIBNISOn1_280038	2.232e-133	432.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XV36@135623|Vibrionales	135623|Vibrionales	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_7812244_5	697281.Mahau_1309	4.454e-79	276.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,42EMP@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM ketose-bisphosphate aldolase, class-II	-	-	4.1.2.13,4.1.2.40	ko:K01624,ko:K08302	ko00010,ko00030,ko00051,ko00052,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01069,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
GDHHQS1_k127_7812244_7	58123.JOFJ01000005_gene1403	3.915e-75	267.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4EN87@85012|Streptosporangiales	201174|Actinobacteria	C	e3 binding domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
GDHHQS1_k127_7812244_6	3656.XP_008464480.1	4.877e-79	280.0	COG0637@1|root,KOG2914@2759|Eukaryota,37KNJ@33090|Viridiplantae,3G8EX@35493|Streptophyta,4JD2Z@91835|fabids	35493|Streptophyta	S	Haloacid dehalogenase-like hydrolase domain-containing protein At3g48420	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD_2
GDHHQS1_k127_7812244_8	1089553.Tph_c27820	5.522e-59	214.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,42EPM@68295|Thermoanaerobacterales	186801|Clostridia	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
GDHHQS1_k127_7812244_0	314256.OG2516_12126	5.281e-140	466.0	COG1082@1|root,COG1082@2|Bacteria,1MVSJ@1224|Proteobacteria,2TV5J@28211|Alphaproteobacteria,2PDP8@252301|Oceanicola	28211|Alphaproteobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
GDHHQS1_k127_7812244_2	518766.Rmar_1734	1.707e-122	404.0	COG0673@1|root,COG0673@2|Bacteria,4NFMS@976|Bacteroidetes,1FJ32@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_7812244_4	1034769.KB910518_gene1014	1.645e-92	313.0	COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,4HCRT@91061|Bacilli,26VSZ@186822|Paenibacillaceae	91061|Bacilli	G	isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_Isome,Fucose_iso_C
GDHHQS1_k127_7813009_1	1122921.KB898188_gene211	4.392e-100	347.0	COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,4HCKV@91061|Bacilli,26WB4@186822|Paenibacillaceae	91061|Bacilli	I	Carboxylesterase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
GDHHQS1_k127_7813009_11	1279009.ADICEAN_01064	4.85e-21	100.0	COG4784@1|root,COG4784@2|Bacteria,4PM59@976|Bacteroidetes,47MK2@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
GDHHQS1_k127_7813009_5	1480694.DC28_04730	9.317e-87	306.0	COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes	203691|Spirochaetes	G	transporter	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
GDHHQS1_k127_7813009_12	269799.Gmet_1951	1.412e-10	63.0	2DGFU@1|root,2ZVU3@2|Bacteria,1P4ND@1224|Proteobacteria,433P8@68525|delta/epsilon subdivisions,2WY4U@28221|Deltaproteobacteria,43VV6@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7813009_9	1499967.BAYZ01000074_gene2080	1.662e-58	207.0	COG1853@1|root,COG1853@2|Bacteria,2NQXP@2323|unclassified Bacteria	2|Bacteria	S	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	actI	-	1.5.1.36	ko:K00484	ko00350,ko00740,ko01100,ko01120,ko01220,map00350,map00740,map01100,map01120,map01220	-	R02698,R03299,R05705,R09748,R09750	RC00046,RC00126	ko00000,ko00001,ko01000	-	-	-	Flavin_Reduct
GDHHQS1_k127_7813009_2	697281.Mahau_0032	3.69e-94	322.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_7813009_6	512565.AMIS_47040	2.953e-85	299.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria,4DHYY@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
GDHHQS1_k127_7813009_10	1254432.SCE1572_41585	2.673e-55	210.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
GDHHQS1_k127_7813009_0	264732.Moth_0513	1.025e-148	484.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,42FTU@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
GDHHQS1_k127_7813009_7	439235.Dalk_1705	6.381e-77	279.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2MIUN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS1_k127_7813009_8	1121403.AUCV01000001_gene871	4.204e-72	268.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2MIA1@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS1_k127_7813009_4	1167006.UWK_00090	9.2e-90	320.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42TE0@68525|delta/epsilon subdivisions,2WPEP@28221|Deltaproteobacteria,2MKDG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS1_k127_7813009_3	589865.DaAHT2_0104	2.695e-92	313.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MJJN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS1_k127_7828289_0	497964.CfE428DRAFT_3030	5.974e-51	185.0	COG0294@1|root,COG0294@2|Bacteria,46SSW@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
GDHHQS1_k127_7828289_2	530564.Psta_2531	4.285e-22	102.0	COG2318@1|root,COG2318@2|Bacteria,2J0C1@203682|Planctomycetes	203682|Planctomycetes	T	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
GDHHQS1_k127_7828289_1	1379698.RBG1_1C00001G0411	1.397e-49	201.0	COG2885@1|root,COG2885@2|Bacteria,2NPWP@2323|unclassified Bacteria	2|Bacteria	M	OmpA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	DUF4384,OmpA,TSP_3
GDHHQS1_k127_7861648_0	665571.STHERM_c16630	2.194e-314	978.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
GDHHQS1_k127_7861648_4	665571.STHERM_c08770	1.377e-09	66.0	2DH0H@1|root,2ZXYI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7861648_1	158190.SpiGrapes_0165	4.631e-90	314.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_7861648_3	351627.Csac_0151	1.09e-28	126.0	COG0569@1|root,COG0569@2|Bacteria,1V2ZF@1239|Firmicutes,24GNX@186801|Clostridia,42H6T@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	trkA2	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
GDHHQS1_k127_7861648_2	357808.RoseRS_3062	4.392e-41	167.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi,377FQ@32061|Chloroflexia	32061|Chloroflexia	C	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
GDHHQS1_k127_7864635_1	1499967.BAYZ01000115_gene2932	2.599e-194	615.0	COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	2.1.2.1,2.1.2.10,2.2.1.8	ko:K00600,ko:K00605,ko:K18847	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R01221,R02300,R04125,R09099	RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C,SHMT
GDHHQS1_k127_7864635_2	767817.Desgi_3968	3.891e-79	274.0	COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,261MU@186807|Peptococcaceae	186801|Clostridia	S	Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3
GDHHQS1_k127_7864635_4	1286171.EAL2_808p07290	6.119e-33	138.0	COG1192@1|root,COG1192@2|Bacteria,1UI78@1239|Firmicutes,25ECF@186801|Clostridia	186801|Clostridia	D	Involved in chromosome partitioning	yqeC	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7864635_3	573370.DMR_06050	1.451e-46	194.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2M9YK@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3,XdhC_C,XdhC_CoxI
GDHHQS1_k127_7864635_0	1123274.KB899407_gene221	0.0	1230.0	COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
GDHHQS1_k127_7864635_5	545694.TREPR_1107	5.834e-17	83.0	COG0006@1|root,COG0006@2|Bacteria,2J5QB@203691|Spirochaetes	203691|Spirochaetes	E	peptidase	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
GDHHQS1_k127_7907945_1	1123508.JH636443_gene4760	1.144e-08	62.0	2DCDW@1|root,2ZDSQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_7907945_0	1254432.SCE1572_37905	7.589e-177	564.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42PXH@68525|delta/epsilon subdivisions,2WKEX@28221|Deltaproteobacteria,2YTWX@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
GDHHQS1_k127_7941505_0	335543.Sfum_1087	9.665e-197	624.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2MQT7@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.18,1.2.1.20,1.2.1.27,1.2.1.3,1.2.1.79,1.2.1.9	ko:K00128,ko:K00131,ko:K00135,ko:K00140	ko00010,ko00030,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00562,ko00620,ko00625,ko00640,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00562,map00620,map00625,map00640,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130,map01200	M00013,M00027,M00135,M00308,M00633	R00264,R00631,R00705,R00706,R00710,R00713,R00714,R00904,R00922,R00935,R01058,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00004,RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS1_k127_7941505_1	485913.Krac_9623	7.578e-131	422.0	COG0258@1|root,COG0258@2|Bacteria	2|Bacteria	L	nuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
GDHHQS1_k127_7941505_3	1265313.HRUBRA_01348	1.67e-79	281.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
GDHHQS1_k127_7941505_4	323259.Mhun_0534	4.063e-47	176.0	COG2249@1|root,arCOG02577@2157|Archaea	2157|Archaea	H	NADPH-quinone reductase (modulator of drug activity B)	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2,UbiA
GDHHQS1_k127_7941505_6	744872.Spica_0325	3.768e-25	109.0	COG2151@1|root,COG2151@2|Bacteria,2JAUU@203691|Spirochaetes	203691|Spirochaetes	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
GDHHQS1_k127_7941505_2	665571.STHERM_c05710	3.363e-102	344.0	COG0396@1|root,COG0396@2|Bacteria,2J5E0@203691|Spirochaetes	203691|Spirochaetes	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
GDHHQS1_k127_7941505_5	1480694.DC28_14505	1.069e-33	134.0	COG0719@1|root,COG0719@2|Bacteria,2J5T1@203691|Spirochaetes	203691|Spirochaetes	O	assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
GDHHQS1_k127_7947496_3	1123392.AQWL01000005_gene3226	6.07e-11	66.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,2VSQ5@28216|Betaproteobacteria,1KT33@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
GDHHQS1_k127_7947496_1	194439.CT0855	1.251e-20	103.0	COG1553@1|root,COG1553@2|Bacteria,1FF6I@1090|Chlorobi	1090|Chlorobi	P	PFAM DsrE family protein	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
GDHHQS1_k127_7947496_2	1123024.AUII01000052_gene3908	8.66e-20	97.0	COG0640@1|root,COG0640@2|Bacteria,2IKPW@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
GDHHQS1_k127_7947496_0	697281.Mahau_0767	9.28e-27	119.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24IZV@186801|Clostridia,42J2I@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_7966492_1	203124.Tery_2383	9.234e-63	247.0	COG0210@1|root,COG0457@1|root,COG0210@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1H968@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TPR_1,TPR_11,TPR_2,TPR_8
GDHHQS1_k127_7966492_0	1237149.C900_03063	1.767e-88	305.0	COG3865@1|root,COG3865@2|Bacteria,4NE70@976|Bacteroidetes,47PVI@768503|Cytophagia	976|Bacteroidetes	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
GDHHQS1_k127_7966492_2	1122918.KB907256_gene2237	3.257e-45	169.0	COG3832@1|root,COG3832@2|Bacteria,1V799@1239|Firmicutes,4HHAD@91061|Bacilli,26WTI@186822|Paenibacillaceae	91061|Bacilli	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS1_k127_8065028_0	330214.NIDE0577	2.088e-188	619.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
GDHHQS1_k127_8065028_3	324925.Ppha_1753	1.554e-49	200.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,Hydrolase_4
GDHHQS1_k127_8065028_4	1123248.KB893315_gene3016	1.53e-33	134.0	COG2764@1|root,COG2764@2|Bacteria,4NSNJ@976|Bacteroidetes,1ITJD@117747|Sphingobacteriia	976|Bacteroidetes	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
GDHHQS1_k127_8065028_1	1125699.HMPREF9194_00901	3.933e-109	369.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
GDHHQS1_k127_8065028_2	1125699.HMPREF9194_00902	3.179e-54	192.0	COG1653@1|root,COG1653@2|Bacteria,2JAFM@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
GDHHQS1_k127_8237199_2	309801.trd_A0400	1.15e-09	60.0	COG1529@1|root,COG1529@2|Bacteria,2G65D@200795|Chloroflexi,27Y2Q@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS1_k127_8237199_0	591019.Shell_0582	5.655e-70	256.0	COG0402@1|root,arCOG00695@2157|Archaea,2XPV1@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS1_k127_8237199_1	420247.Msm_1044	6.261e-12	73.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,23NRT@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
GDHHQS1_k127_8280594_2	760011.Spico_0884	2.929e-37	144.0	COG1022@1|root,COG1022@2|Bacteria,2J6MK@203691|Spirochaetes	203691|Spirochaetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
GDHHQS1_k127_8280594_0	665571.STHERM_c16030	2.595e-274	859.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
GDHHQS1_k127_8280594_1	1191523.MROS_0957	2.524e-121	405.0	COG0572@1|root,COG0572@2|Bacteria	2|Bacteria	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
GDHHQS1_k127_8280594_4	1120958.AULD01000007_gene1209	0.000293	51.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4FK75@85023|Microbacteriaceae	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
GDHHQS1_k127_8280594_3	1321815.HMPREF9193_00854	4.274e-33	129.0	COG0488@1|root,COG0488@2|Bacteria,2J5P1@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
GDHHQS1_k127_8283193_5	744872.Spica_1046	1.676e-68	237.0	COG1435@1|root,COG1435@2|Bacteria,2J6SK@203691|Spirochaetes	203691|Spirochaetes	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
GDHHQS1_k127_8283193_13	744872.Spica_1482	9.891e-20	102.0	290DX@1|root,32INT@2|Bacteria,2J83J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8283193_0	742821.HMPREF9464_01378	6.391e-181	593.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,4PQNJ@995019|Sutterellaceae	28216|Betaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_8283193_1	1499967.BAYZ01000123_gene2488	5.52e-163	526.0	COG2160@1|root,COG2160@2|Bacteria	2|Bacteria	G	L-arabinose isomerase activity	-	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome,Fucose_iso_C
GDHHQS1_k127_8283193_4	1174528.JH992893_gene5997	7.625e-79	277.0	COG2017@1|root,COG2017@2|Bacteria,1GGS7@1117|Cyanobacteria	1117|Cyanobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8283193_11	1122214.AQWH01000035_gene50	1.22e-26	125.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2PJD5@255475|Aurantimonadaceae	28211|Alphaproteobacteria	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK_1	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_8283193_12	1499967.BAYZ01000123_gene2492	3.238e-26	126.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	5.4.3.8	ko:K01845,ko:K07100	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Amidohydro_2,Aminotran_3
GDHHQS1_k127_8283193_15	1123075.AUDP01000010_gene1365	2.276e-05	56.0	COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia,3WNHP@541000|Ruminococcaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_8283193_3	196367.JNFG01000020_gene4661	1.492e-82	290.0	COG1653@1|root,COG1653@2|Bacteria,1MWHT@1224|Proteobacteria,2VP3P@28216|Betaproteobacteria,1KHR7@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10117	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_8283193_8	1034769.KB910518_gene733	6.039e-50	191.0	COG1175@1|root,COG1175@2|Bacteria,1V0RN@1239|Firmicutes,4IQN5@91061|Bacilli,276FW@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
GDHHQS1_k127_8283193_9	742735.HMPREF9467_04256	1.882e-42	166.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A48@186801|Clostridia,220J6@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
GDHHQS1_k127_8283193_7	180332.JTGN01000021_gene1375	3.955e-54	206.0	COG5012@1|root,COG5012@2|Bacteria,1V82H@1239|Firmicutes,24JSA@186801|Clostridia	186801|Clostridia	S	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8283193_2	1499967.BAYZ01000123_gene2492	5.208e-127	415.0	COG3618@1|root,COG3618@2|Bacteria	2|Bacteria	H	amidohydrolase	-	-	5.4.3.8	ko:K01845,ko:K07100	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Amidohydro_2,Aminotran_3
GDHHQS1_k127_8283193_10	42256.RradSPS_3024	8.409e-28	123.0	COG1830@1|root,COG1830@2|Bacteria,2IB09@201174|Actinobacteria	201174|Actinobacteria	G	Aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
GDHHQS1_k127_8283193_6	1303518.CCALI_02464	5.28e-55	197.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_8302077_1	326427.Cagg_1321	9.529e-117	392.0	COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
GDHHQS1_k127_8302077_3	1242864.D187_008025	3.048e-90	310.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8302077_8	1192034.CAP_5968	3.039e-23	105.0	COG4430@1|root,COG4430@2|Bacteria,1QZAG@1224|Proteobacteria	1224|Proteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
GDHHQS1_k127_8302077_4	744872.Spica_2856	1.604e-83	286.0	COG4939@1|root,COG4939@2|Bacteria,2J7W0@203691|Spirochaetes	203691|Spirochaetes	S	FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8302077_7	1035308.AQYY01000001_gene2141	8.415e-27	124.0	COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,2481K@186801|Clostridia,2604Q@186807|Peptococcaceae	186801|Clostridia	C	Oxidoreductase	fixC	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
GDHHQS1_k127_8302077_11	1121422.AUMW01000033_gene3372	0.0006898	50.0	COG1149@1|root,COG1149@2|Bacteria,1TQI9@1239|Firmicutes,2484J@186801|Clostridia,261J0@186807|Peptococcaceae	186801|Clostridia	C	Cobyrinic acid ac-diamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
GDHHQS1_k127_8302077_10	298655.KI912267_gene7503	0.0001699	51.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4ETJH@85013|Frankiales	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
GDHHQS1_k127_8302077_9	1123037.AUDE01000012_gene191	1.58e-06	58.0	2EWWW@1|root,33Q89@2|Bacteria,4P114@976|Bacteroidetes,1I84I@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8302077_2	1254432.SCE1572_47310	1.887e-97	331.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
GDHHQS1_k127_8302077_0	96561.Dole_3268	1.296e-146	497.0	COG0784@1|root,COG2202@1|root,COG3275@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3275@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
GDHHQS1_k127_8302077_5	1382306.JNIM01000001_gene3662	6.866e-41	160.0	COG1595@1|root,COG1595@2|Bacteria,2G93G@200795|Chloroflexi	200795|Chloroflexi	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS1_k127_8302077_6	1122138.AQUZ01000044_gene4502	3.855e-38	151.0	COG0701@1|root,COG0701@2|Bacteria,2HZBT@201174|Actinobacteria	201174|Actinobacteria	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
GDHHQS1_k127_8325306_3	1521187.JPIM01000001_gene834	3.667e-18	90.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS1_k127_8325306_1	234267.Acid_3395	7.174e-42	158.0	2FGUY@1|root,348Q9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8325306_4	1048834.TC41_1239	2.526e-16	91.0	COG0477@1|root,COG2814@2|Bacteria,1V19N@1239|Firmicutes,4HDX3@91061|Bacilli	91061|Bacilli	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_8325306_2	768706.Desor_3537	5.661e-39	151.0	COG3797@1|root,COG3797@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
GDHHQS1_k127_8325306_0	203124.Tery_2383	1.407e-61	240.0	COG0210@1|root,COG0457@1|root,COG0210@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1H968@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TPR_1,TPR_11,TPR_2,TPR_8
GDHHQS1_k127_8371835_12	511051.CSE_05950	9.934e-30	124.0	COG0704@1|root,COG0704@2|Bacteria	2|Bacteria	P	negative regulation of phosphate transmembrane transport	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0060255,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
GDHHQS1_k127_8371835_3	909663.KI867150_gene311	1.263e-105	362.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MR99@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
GDHHQS1_k127_8371835_6	1123371.ATXH01000005_gene2120	4.103e-68	244.0	COG0581@1|root,COG0581@2|Bacteria,2GGUY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
GDHHQS1_k127_8371835_5	1123248.KB893314_gene3515	1.045e-84	290.0	COG0573@1|root,COG0573@2|Bacteria,4NEGX@976|Bacteroidetes,1IWST@117747|Sphingobacteriia	976|Bacteroidetes	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
GDHHQS1_k127_8371835_2	909663.KI867150_gene308	9.604e-115	380.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria,2MRNS@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
GDHHQS1_k127_8371835_4	909663.KI867150_gene1440	3.7e-101	353.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MQCA@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
GDHHQS1_k127_8371835_8	909663.KI867150_gene1439	4.966e-65	231.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07657,ko:K07663	ko02020,map02020	M00434,M00449	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS1_k127_8371835_10	304371.MCP_1389	1.467e-37	160.0	arCOG02449@1|root,arCOG02449@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
GDHHQS1_k127_8371835_7	1499967.BAYZ01000095_gene4182	4.22e-65	241.0	COG1486@1|root,COG1486@2|Bacteria,2NQP2@2323|unclassified Bacteria	2|Bacteria	G	Family 4 glycosyl hydrolase	lplD	-	3.2.1.22,3.2.1.86	ko:K01222,ko:K07406	ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603	-	R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091	RC00049,RC00059,RC00171,RC00451,RC00714	ko00000,ko00001,ko01000	-	GT4	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_8371835_9	1489678.RDMS_02810	2.135e-58	214.0	COG1028@1|root,COG1028@2|Bacteria,1WM2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
GDHHQS1_k127_8371835_0	1038859.AXAU01000015_gene1038	2.436e-207	673.0	COG2133@1|root,COG2133@2|Bacteria,1R8DY@1224|Proteobacteria,2U4BZ@28211|Alphaproteobacteria,3JXE5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8371835_1	742725.HMPREF9450_01626	8.51e-182	593.0	COG1874@1|root,COG1874@2|Bacteria,4P500@976|Bacteroidetes	976|Bacteroidetes	G	Beta-galactosidase	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42
GDHHQS1_k127_8371835_11	1123075.AUDP01000024_gene1090	2.438e-36	139.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes,24EHD@186801|Clostridia,3WKR9@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
GDHHQS1_k127_8394304_6	1123274.KB899407_gene218	1.963e-21	98.0	COG5341@1|root,COG5341@2|Bacteria,2J8UX@203691|Spirochaetes	203691|Spirochaetes	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
GDHHQS1_k127_8394304_4	889378.Spiaf_1983	1.977e-42	163.0	COG4769@1|root,COG4769@2|Bacteria,2J81I@203691|Spirochaetes	203691|Spirochaetes	S	heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
GDHHQS1_k127_8394304_7	889378.Spiaf_1982	1.036e-17	91.0	2DEN8@1|root,2ZNJD@2|Bacteria,2J8NJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8394304_2	926561.KB900622_gene616	1.581e-49	197.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24DJF@186801|Clostridia,3WBRF@53433|Halanaerobiales	186801|Clostridia	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS19835	UbiA
GDHHQS1_k127_8394304_3	545695.TREAZ_2925	4.808e-46	189.0	COG0715@1|root,COG0715@2|Bacteria,2J7TW@203691|Spirochaetes	203691|Spirochaetes	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
GDHHQS1_k127_8394304_0	1121456.ATVA01000013_gene853	4.029e-66	234.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42MQ5@68525|delta/epsilon subdivisions,2WK19@28221|Deltaproteobacteria,2MH0B@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
GDHHQS1_k127_8394304_1	500635.MITSMUL_05255	1.247e-59	215.0	COG0600@1|root,COG0600@2|Bacteria,1V3NA@1239|Firmicutes,4H2YK@909932|Negativicutes	909932|Negativicutes	P	ABC transporter, permease protein	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
GDHHQS1_k127_8394304_5	545695.TREAZ_2929	5.547e-41	155.0	COG1477@1|root,COG1477@2|Bacteria,2J5JH@203691|Spirochaetes	203691|Spirochaetes	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
GDHHQS1_k127_8423405_3	1123075.AUDP01000025_gene372	3.528e-67	244.0	COG0407@1|root,COG0407@2|Bacteria,1VUB8@1239|Firmicutes,24JGI@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_8423405_4	1463901.JOIY01000043_gene703	7.299e-43	178.0	COG3618@1|root,COG3618@2|Bacteria,2GM2D@201174|Actinobacteria	201174|Actinobacteria	C	amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
GDHHQS1_k127_8423405_6	485913.Krac_8140	2.515e-32	137.0	COG2188@1|root,COG2188@2|Bacteria,2G6ST@200795|Chloroflexi	200795|Chloroflexi	K	SPTR D1CI93 Phophonate C-P lyase system transcriptional regulator PhnF, GntR family	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
GDHHQS1_k127_8423405_5	469383.Cwoe_4459	3.601e-35	148.0	COG0673@1|root,COG0673@2|Bacteria,2IEY3@201174|Actinobacteria,4CTIF@84995|Rubrobacteria	84995|Rubrobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_8423405_0	391735.Veis_1877	2.464e-115	392.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,4AEAX@80864|Comamonadaceae	28216|Betaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_8423405_2	553973.CLOHYLEM_05690	8.03e-87	298.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,250C5@186801|Clostridia,222PR@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh
GDHHQS1_k127_8423405_1	553973.CLOHYLEM_05689	9.365e-106	355.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,221X6@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS1_k127_8423405_9	324602.Caur_1691	2.105e-14	76.0	COG0508@1|root,COG0508@2|Bacteria,2G5TB@200795|Chloroflexi,3759C@32061|Chloroflexia	32061|Chloroflexia	C	catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
GDHHQS1_k127_8423405_8	572546.Arcpr_0384	1.933e-18	93.0	COG0432@1|root,arCOG04214@2157|Archaea,2XXSW@28890|Euryarchaeota,246A9@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
GDHHQS1_k127_8423405_7	887929.HMP0721_1692	5.439e-24	110.0	COG0698@1|root,COG0698@2|Bacteria,1V2VV@1239|Firmicutes,24GCM@186801|Clostridia,25W2Y@186806|Eubacteriaceae	186801|Clostridia	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
GDHHQS1_k127_8473763_0	1304888.ATWF01000001_gene1470	4.894e-148	480.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2GFDI@200930|Deferribacteres	2|Bacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF,GAF_2,HD,PAS_3,PAS_9,Response_reg
GDHHQS1_k127_8473763_1	479434.Sthe_1344	1.58e-58	217.0	COG0309@1|root,COG0309@2|Bacteria,2G8E4@200795|Chloroflexi,27XEQ@189775|Thermomicrobia	189775|Thermomicrobia	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
GDHHQS1_k127_8473763_3	744872.Spica_1336	5.736e-36	152.0	2AMQG@1|root,31CKP@2|Bacteria,2J7X3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8473763_2	889378.Spiaf_1381	7.51e-56	204.0	COG0514@1|root,COG0514@2|Bacteria,2J5BY@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
GDHHQS1_k127_8599055_11	1385935.N836_09970	5.809e-39	153.0	COG1985@1|root,COG1985@2|Bacteria	2|Bacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	MA20_21040	-	1.1.1.193,1.1.1.302,3.5.4.26	ko:K00082,ko:K11752,ko:K14654	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459,R09375,R09376	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
GDHHQS1_k127_8599055_5	880073.Calab_3788	4.997e-60	223.0	COG0451@1|root,COG0451@2|Bacteria,2NPC7@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	JD73_00815	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
GDHHQS1_k127_8599055_2	251221.35211940	1.62e-100	366.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1G5W7@1117|Cyanobacteria	1117|Cyanobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
GDHHQS1_k127_8599055_3	573413.Spirs_1437	6.161e-74	261.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
GDHHQS1_k127_8599055_9	34506.g6609	5.843e-55	211.0	COG0251@1|root,COG0458@1|root,KOG0370@2759|Eukaryota,KOG2317@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,40G12@6231|Nematoda,1KYNR@119089|Chromadorea,40UXW@6236|Rhabditida	33208|Metazoa	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	CPS1	GO:0000050,GO:0000052,GO:0000096,GO:0000166,GO:0001101,GO:0001505,GO:0001889,GO:0002237,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0004175,GO:0005488,GO:0005509,GO:0005524,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006082,GO:0006508,GO:0006520,GO:0006525,GO:0006526,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0007494,GO:0008015,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008289,GO:0008652,GO:0009056,GO:0009058,GO:0009064,GO:0009084,GO:0009295,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010243,GO:0014070,GO:0014074,GO:0014075,GO:0016020,GO:0016042,GO:0016053,GO:0016595,GO:0016597,GO:0016787,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0017144,GO:0019240,GO:0019433,GO:0019538,GO:0019627,GO:0019637,GO:0019752,GO:0019866,GO:0030154,GO:0030554,GO:0030855,GO:0031090,GO:0031406,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032094,GO:0032496,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032991,GO:0033762,GO:0033993,GO:0034201,GO:0034641,GO:0035150,GO:0035295,GO:0035296,GO:0035639,GO:0036094,GO:0042133,GO:0042221,GO:0042311,GO:0042493,GO:0042592,GO:0042594,GO:0042645,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043200,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044283,GO:0044344,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0046209,GO:0046394,GO:0046461,GO:0046464,GO:0046486,GO:0046503,GO:0046683,GO:0046872,GO:0048513,GO:0048545,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050667,GO:0050801,GO:0050880,GO:0050896,GO:0051384,GO:0051591,GO:0051704,GO:0051707,GO:0051716,GO:0055081,GO:0055123,GO:0060416,GO:0060429,GO:0061008,GO:0065007,GO:0065008,GO:0070011,GO:0070013,GO:0070365,GO:0070408,GO:0070409,GO:0070542,GO:0070848,GO:0070887,GO:0071229,GO:0071310,GO:0071320,GO:0071363,GO:0071375,GO:0071377,GO:0071396,GO:0071398,GO:0071400,GO:0071407,GO:0071417,GO:0071495,GO:0071548,GO:0071704,GO:0071774,GO:0071941,GO:0072341,GO:0072593,GO:0090066,GO:0090407,GO:0097159,GO:0097237,GO:0097327,GO:0097367,GO:0097746,GO:0097755,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901653,GO:1901654,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903717,GO:1903718,GO:2001057	6.3.4.16	ko:K01948	ko00220,ko00250,ko00910,ko01100,ko01120,ko01200,ko01230,map00220,map00250,map00910,map01100,map01120,map01200,map01230	M00029	R00149	RC00002,RC02804	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
GDHHQS1_k127_8599055_12	906968.Trebr_1303	2.931e-35	144.0	COG0564@1|root,COG0564@2|Bacteria,2J82Z@203691|Spirochaetes	203691|Spirochaetes	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
GDHHQS1_k127_8599055_10	243275.TDE_1290	1.051e-48	190.0	2BN9R@1|root,32GX8@2|Bacteria,2JAW7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8599055_4	1128421.JAGA01000003_gene3256	9.838e-66	248.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
GDHHQS1_k127_8599055_8	697281.Mahau_2597	9.144e-57	222.0	COG5012@1|root,COG5012@2|Bacteria,1UF8A@1239|Firmicutes,24CAU@186801|Clostridia	186801|Clostridia	S	cobalamin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8599055_1	1499967.BAYZ01000069_gene1886	4.408e-120	395.0	COG0167@1|root,COG0167@2|Bacteria,2NPB9@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
GDHHQS1_k127_8599055_6	1125700.HMPREF9195_01931	3.656e-59	216.0	COG0761@1|root,COG0761@2|Bacteria,2J56Z@203691|Spirochaetes	203691|Spirochaetes	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
GDHHQS1_k127_8599055_7	665571.STHERM_c17140	3.316e-58	215.0	COG0142@1|root,COG0142@2|Bacteria	2|Bacteria	H	isoprenoid biosynthetic process	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
GDHHQS1_k127_8599055_0	545694.TREPR_1176	7.325e-190	603.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
GDHHQS1_k127_8599055_13	1157638.KB892166_gene4657	7.7e-24	111.0	COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the carbohydrate kinase PfkB family	fruK	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
GDHHQS1_k127_8679883_0	667014.Thein_0257	6.835e-149	482.0	COG0458@1|root,COG0458@2|Bacteria,2GH37@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
GDHHQS1_k127_8694113_7	243231.GSU2525	2.547e-22	103.0	COG0778@1|root,COG0778@2|Bacteria,1RECN@1224|Proteobacteria,42SPP@68525|delta/epsilon subdivisions,2WPPZ@28221|Deltaproteobacteria,43VP5@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS1_k127_8694113_6	479434.Sthe_2858	1.436e-25	120.0	COG0714@1|root,COG2304@1|root,COG0714@2|Bacteria,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K03924,ko:K04748,ko:K07114	-	-	R00294	RC02794	ko00000,ko01000,ko02000	1.A.13.2.2,1.A.13.2.3,3.D.4.10	-	-	AAA_5,BatA,DUF4159,VIT,VWA_2,VWA_CoxE
GDHHQS1_k127_8694113_1	374847.Kcr_1472	7.302e-59	219.0	COG0714@1|root,arCOG00441@2157|Archaea	2157|Archaea	V	ATPase associated with various cellular activities, AAA_5	gvpN	-	-	ko:K03924,ko:K04748	-	-	R00294	RC02794	ko00000,ko01000	3.D.4.10	-	-	AAA_5,CbbQ_C,HHH_5
GDHHQS1_k127_8694113_3	1217720.ALOX01000067_gene2626	2.26e-39	166.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2TU12@28211|Alphaproteobacteria,2JPDR@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
GDHHQS1_k127_8694113_4	889378.Spiaf_0831	6.316e-34	148.0	COG2176@1|root,COG2176@2|Bacteria,2JBJN@203691|Spirochaetes	203691|Spirochaetes	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
GDHHQS1_k127_8694113_0	368408.Tpen_0002	1.879e-110	368.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
GDHHQS1_k127_8694113_2	573413.Spirs_0879	1.439e-49	201.0	COG0013@1|root,COG0013@2|Bacteria,2J75I@203691|Spirochaetes	203691|Spirochaetes	J	alanyl tRNA synthetase	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
GDHHQS1_k127_8694113_5	717605.Theco_2678	3.441e-31	137.0	COG0477@1|root,COG2814@2|Bacteria,1V19N@1239|Firmicutes,4HDX3@91061|Bacilli,26TWU@186822|Paenibacillaceae	91061|Bacilli	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_8705439_0	545695.TREAZ_2760	1.232e-122	400.0	28MXM@1|root,2Z8AT@2|Bacteria,2JBFX@203691|Spirochaetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8705439_2	391600.ABRU01000056_gene465	8.879e-07	56.0	2EMPE@1|root,33FBV@2|Bacteria,1NGMP@1224|Proteobacteria,2UMQY@28211|Alphaproteobacteria,2KJDG@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8705439_1	1123372.AUIT01000012_gene1693	6.609e-25	120.0	COG3103@1|root,COG4991@2|Bacteria,2GHRI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8755050_0	234267.Acid_7250	1.847e-53	193.0	COG0386@1|root,COG0386@2|Bacteria,3Y4B8@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
GDHHQS1_k127_8755050_3	1131462.DCF50_p1700	1.779e-27	117.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,2632C@186807|Peptococcaceae	186801|Clostridia	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
GDHHQS1_k127_8755050_1	1047013.AQSP01000068_gene2283	8.207e-31	126.0	2FIP3@1|root,34AEW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8755050_2	1120954.ATXE01000004_gene88	2.543e-28	133.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,DUF3459
GDHHQS1_k127_8770111_5	177437.HRM2_06330	6.253e-61	213.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42QQQ@68525|delta/epsilon subdivisions,2WMBP@28221|Deltaproteobacteria,2MIM7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS1_k127_8770111_2	177437.HRM2_06340	6.518e-112	377.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,42P6E@68525|delta/epsilon subdivisions,2WISH@28221|Deltaproteobacteria,2MHMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS1_k127_8770111_4	1121289.JHVL01000004_gene2118	4.026e-66	236.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,36E22@31979|Clostridiaceae	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	pduL	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,PTAC
GDHHQS1_k127_8770111_7	1280664.AUIX01000012_gene3705	2.076e-27	126.0	COG4886@1|root,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia,4C1CR@830|Butyrivibrio	186801|Clostridia	S	leucine-rich repeat-containing protein typical subtype	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	CW_binding_2,DUF3888,GA-like,LRR_4,LRR_6,LRR_8
GDHHQS1_k127_8770111_3	1121438.JNJA01000008_gene3867	3.507e-100	351.0	COG1226@1|root,COG2114@1|root,COG1226@2|Bacteria,COG2114@2|Bacteria,1R86S@1224|Proteobacteria,4317C@68525|delta/epsilon subdivisions,2WWWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8770111_1	1379270.AUXF01000004_gene2893	1.07e-226	714.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
GDHHQS1_k127_8770111_8	744872.Spica_2496	1.452e-21	110.0	COG0607@1|root,COG0607@2|Bacteria,2J8B4@203691|Spirochaetes	203691|Spirochaetes	P	Rhodanese Homology Domain	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
GDHHQS1_k127_8770111_9	96561.Dole_3265	1.243e-13	77.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
GDHHQS1_k127_8770111_0	1121405.dsmv_1129	1.532e-284	913.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
GDHHQS1_k127_8770111_6	545695.TREAZ_2760	7.605e-41	155.0	28MXM@1|root,2Z8AT@2|Bacteria,2JBFX@203691|Spirochaetes	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_8776774_0	889378.Spiaf_2221	8.784e-105	349.0	COG0399@1|root,COG0399@2|Bacteria,2J62G@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
GDHHQS1_k127_8776774_1	1435051.BMOU_0468	1.053e-49	185.0	COG2017@1|root,COG2017@2|Bacteria,2IDCU@201174|Actinobacteria,4D0FY@85004|Bifidobacteriales	201174|Actinobacteria	G	Domain of unknown function (DUF4432)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4432
GDHHQS1_k127_8886489_0	889378.Spiaf_1956	1.095e-49	191.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
GDHHQS1_k127_8886489_1	1480694.DC28_03000	6.212e-48	179.0	COG0299@1|root,COG0299@2|Bacteria	2|Bacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
GDHHQS1_k127_8886489_2	1480694.DC28_03005	3.584e-32	130.0	COG0150@1|root,COG0150@2|Bacteria,2J5AP@203691|Spirochaetes	203691|Spirochaetes	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
GDHHQS1_k127_9040015_0	1499967.BAYZ01000090_gene4959	9.402e-263	819.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2NNT2@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K00167,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
GDHHQS1_k127_9040015_8	1380355.JNIJ01000048_gene33	2.366e-06	53.0	2AHTU@1|root,3186F@2|Bacteria,1NN1Q@1224|Proteobacteria,2UTGK@28211|Alphaproteobacteria,3K4KG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
GDHHQS1_k127_9040015_9	1122239.AULS01000001_gene1710	8.394e-06	56.0	COG1848@1|root,COG1848@2|Bacteria,2HS5J@201174|Actinobacteria,4FT1I@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
GDHHQS1_k127_9040015_1	497964.CfE428DRAFT_0391	6.499e-174	557.0	COG1904@1|root,COG1904@2|Bacteria,46SH8@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
GDHHQS1_k127_9040015_5	1304880.JAGB01000003_gene1231	5.381e-110	363.0	COG4813@1|root,COG4813@2|Bacteria,1TPZ1@1239|Firmicutes,24EF0@186801|Clostridia	186801|Clostridia	G	Trehalose utilisation	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
GDHHQS1_k127_9040015_4	1033743.CAES01000046_gene277	2.591e-116	398.0	COG0673@1|root,COG0673@2|Bacteria,1UWP1@1239|Firmicutes,4I6SZ@91061|Bacilli,26USD@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_9040015_2	234267.Acid_6969	5.449e-150	502.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_9040015_3	1121439.dsat_1867	1.765e-130	422.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2M9HW@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
GDHHQS1_k127_9040015_7	521045.Kole_0734	1.273e-18	99.0	COG4552@1|root,COG4552@2|Bacteria,2GE2S@200918|Thermotogae	200918|Thermotogae	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
GDHHQS1_k127_9040015_6	1379270.AUXF01000003_gene3436	1.733e-26	117.0	COG0153@1|root,COG0153@2|Bacteria,1ZU6F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Belongs to the GHMP kinase family	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
GDHHQS1_k127_9085447_2	511.JT27_17595	4.146e-06	59.0	COG2271@1|root,COG2271@2|Bacteria,1P9MX@1224|Proteobacteria,2W7FV@28216|Betaproteobacteria,3T5K1@506|Alcaligenaceae	28216|Betaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_9085447_0	697281.Mahau_1515	7.836e-33	138.0	COG2220@1|root,COG2220@2|Bacteria,1TSFV@1239|Firmicutes,249MG@186801|Clostridia	186801|Clostridia	S	Beta-lactamase superfamily domain	ulaG	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactamase_B_2,Lactamase_B_3
GDHHQS1_k127_9085447_1	1122175.ATXU01000015_gene421	2.191e-14	84.0	COG4977@1|root,COG4977@2|Bacteria,2GIRA@201174|Actinobacteria,4FMKS@85023|Microbacteriaceae	201174|Actinobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
GDHHQS1_k127_9085447_3	545695.TREAZ_0999	1.551e-05	48.0	COG1486@1|root,COG1486@2|Bacteria,2J6Z5@203691|Spirochaetes	203691|Spirochaetes	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_9088973_4	762983.HMPREF9444_01966	1.665e-18	91.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1Y3K7@135624|Aeromonadales	135624|Aeromonadales	J	Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
GDHHQS1_k127_9088973_3	545695.TREAZ_0764	2.257e-38	150.0	2EQ1S@1|root,33HN8@2|Bacteria,2J7UJ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9088973_2	1307761.L21SP2_1920	9.022e-40	170.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	GGDEF,HATPase_c,HisKA,cNMP_binding
GDHHQS1_k127_9088973_1	517418.Ctha_1299	4.844e-77	273.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	yugO	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
GDHHQS1_k127_9088973_6	1321815.HMPREF9193_00994	1.466e-15	90.0	COG1470@1|root,COG1470@2|Bacteria,2JBDC@203691|Spirochaetes	203691|Spirochaetes	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,PEGA
GDHHQS1_k127_9088973_5	1123274.KB899409_gene444	4.326e-16	84.0	COG1933@1|root,COG1933@2|Bacteria,2J8VX@203691|Spirochaetes	203691|Spirochaetes	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
GDHHQS1_k127_9088973_0	479434.Sthe_0322	4.657e-83	290.0	COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,27XGT@189775|Thermomicrobia	189775|Thermomicrobia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
GDHHQS1_k127_9094023_6	1123274.KB899419_gene1903	1.67e-75	259.0	2EY48@1|root,33RD4@2|Bacteria,2J65N@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
GDHHQS1_k127_9094023_7	573413.Spirs_2587	3.314e-65	243.0	2EY48@1|root,33UVP@2|Bacteria,2J5KT@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein FlaA	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
GDHHQS1_k127_9094023_5	596152.DesU5LDRAFT_2194	2.455e-78	279.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2WIJQ@28221|Deltaproteobacteria,2MA47@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
GDHHQS1_k127_9094023_0	639282.DEFDS_0062	8.819e-155	494.0	COG0191@1|root,COG0191@2|Bacteria,2GETH@200930|Deferribacteres	200930|Deferribacteres	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
GDHHQS1_k127_9094023_1	889378.Spiaf_2151	4.599e-141	460.0	COG0035@1|root,COG0035@2|Bacteria,2J5NG@203691|Spirochaetes	203691|Spirochaetes	F	uracil phosphoribosyltransferase	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
GDHHQS1_k127_9094023_3	1463841.JOIR01000003_gene5617	1.39e-112	377.0	COG0673@1|root,COG0673@2|Bacteria,2GJNE@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS1_k127_9094023_8	665571.STHERM_c07350	8.187e-62	217.0	COG0503@1|root,COG0503@2|Bacteria,2J7CM@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
GDHHQS1_k127_9094023_2	906968.Trebr_1828	8.707e-135	444.0	COG0533@1|root,COG0533@2|Bacteria,2J5WG@203691|Spirochaetes	203691|Spirochaetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
GDHHQS1_k127_9094023_10	665571.STHERM_c07330	1.164e-58	214.0	COG2861@1|root,COG2861@2|Bacteria,2J75Z@203691|Spirochaetes	203691|Spirochaetes	S	Divergent polysaccharide deacetylase	-	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
GDHHQS1_k127_9094023_4	744872.Spica_0849	3.784e-99	331.0	COG0568@1|root,COG0568@2|Bacteria,2J7R0@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS1_k127_9094023_11	1289135.A966_07934	4.977e-20	94.0	COG3951@1|root,COG3951@2|Bacteria	2|Bacteria	MNO	Flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02035	-	GH23	-	Rod-binding
GDHHQS1_k127_9094023_9	401526.TcarDRAFT_1479	8.361e-61	223.0	COG1706@1|root,COG1706@2|Bacteria,1U2PI@1239|Firmicutes,4H258@909932|Negativicutes	909932|Negativicutes	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
GDHHQS1_k127_9094023_12	1123274.KB899415_gene2404	2.902e-10	61.0	COG4786@1|root,COG4786@2|Bacteria,2J57D@203691|Spirochaetes	203691|Spirochaetes	N	flagellar basal-body rod protein FlgG	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
GDHHQS1_k127_9094781_1	665571.STHERM_c01840	4.604e-107	351.0	COG0133@1|root,COG0133@2|Bacteria,2J5J8@203691|Spirochaetes	203691|Spirochaetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
GDHHQS1_k127_9094781_5	889378.Spiaf_2547	3.8e-55	211.0	COG0159@1|root,COG0159@2|Bacteria,2J6HT@203691|Spirochaetes	203691|Spirochaetes	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
GDHHQS1_k127_9094781_6	660470.Theba_2456	9.058e-49	199.0	COG1262@1|root,COG1262@2|Bacteria,2GEAZ@200918|Thermotogae	200918|Thermotogae	O	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PDZ_2
GDHHQS1_k127_9094781_9	545695.TREAZ_3420	3.084e-16	91.0	2AM4M@1|root,31BYU@2|Bacteria,2J5QA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9094781_2	545695.TREAZ_3422	1.532e-77	291.0	29WTR@1|root,30IF4@2|Bacteria,2J6NC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9094781_0	357808.RoseRS_2242	1.144e-126	447.0	COG0477@1|root,COG2814@2|Bacteria,2G71K@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS1_k127_9094781_4	95619.PM1_0209780	3.228e-70	266.0	COG0388@1|root,COG0388@2|Bacteria,1P8FV@1224|Proteobacteria	1224|Proteobacteria	S	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
GDHHQS1_k127_9094781_7	1094508.Tsac_0458	7.647e-34	139.0	COG0204@1|root,COG0204@2|Bacteria,1V5X9@1239|Firmicutes,24X01@186801|Clostridia	186801|Clostridia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9094781_8	1321778.HMPREF1982_03176	1.181e-21	99.0	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
GDHHQS1_k127_9094781_10	221027.JO40_02695	2.012e-06	57.0	28X9U@1|root,2ZJ7V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9094781_3	1123274.KB899411_gene3193	7.235e-72	246.0	COG2236@1|root,COG2236@2|Bacteria,2JAE0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
GDHHQS1_k127_9097890_3	637910.ROD_33951	5.497e-149	481.0	COG0402@1|root,COG0402@2|Bacteria,1PDYK@1224|Proteobacteria,1TKM4@1236|Gammaproteobacteria,3WY0U@544|Citrobacter	1236|Gammaproteobacteria	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS1_k127_9097890_6	1499967.BAYZ01000073_gene2013	5.688e-47	183.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
GDHHQS1_k127_9097890_2	1499967.BAYZ01000188_gene3895	1.292e-158	525.0	COG0624@1|root,COG0624@2|Bacteria,2NNX2@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
GDHHQS1_k127_9097890_0	1123274.KB899409_gene554	4.311e-247	781.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS1_k127_9097890_7	1121440.AUMA01000016_gene127	3.381e-44	183.0	COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,42RRP@68525|delta/epsilon subdivisions,2WP0I@28221|Deltaproteobacteria,2MBFY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 2Fe-2S -binding	-	-	1.2.5.3	ko:K03518,ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
GDHHQS1_k127_9097890_5	573413.Spirs_1391	2.911e-53	204.0	COG1319@1|root,COG1319@2|Bacteria,2J80S@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	coxM	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
GDHHQS1_k127_9097890_4	926569.ANT_01260	1.403e-123	421.0	COG0549@1|root,COG0549@2|Bacteria,2G6C7@200795|Chloroflexi	200795|Chloroflexi	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
GDHHQS1_k127_9097890_1	1123274.KB899409_gene551	9.62e-184	598.0	COG0402@1|root,COG0402@2|Bacteria,2J6KS@203691|Spirochaetes	203691|Spirochaetes	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS1_k127_9097890_8	1449126.JQKL01000042_gene1015	1.372e-28	123.0	COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia,269PH@186813|unclassified Clostridiales	186801|Clostridia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS1_k127_9105026_1	545695.TREAZ_2901	1.297e-163	542.0	COG1874@1|root,COG1874@2|Bacteria,2J8P9@203691|Spirochaetes	203691|Spirochaetes	G	Hypothetical glycosyl hydrolase 6	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
GDHHQS1_k127_9105026_0	697281.Mahau_1817	1.926e-197	621.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia,42ES0@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Mandelate racemase muconate lactonizing enzyme	-	GO:0000287,GO:0003674,GO:0005488,GO:0043167,GO:0043169,GO:0046872	4.2.1.5,4.2.1.6,4.2.1.8	ko:K01683,ko:K01684,ko:K08323	ko00040,ko00052,ko01100,ko01120,map00040,map00052,map01100,map01120	M00061,M00552	R03033,R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS1_k127_9129290_7	1321778.HMPREF1982_01904	2.487e-89	301.0	COG1814@1|root,COG1814@2|Bacteria,1V4D2@1239|Firmicutes	1239|Firmicutes	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
GDHHQS1_k127_9129290_6	335543.Sfum_2394	5.973e-96	333.0	COG0535@1|root,COG0535@2|Bacteria,1R8PU@1224|Proteobacteria,42Q6I@68525|delta/epsilon subdivisions,2WKZV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
GDHHQS1_k127_9129290_12	621372.ACIH01000035_gene790	4.362e-47	176.0	COG2039@1|root,COG2039@2|Bacteria,1TRRX@1239|Firmicutes,4HCIJ@91061|Bacilli,26WF6@186822|Paenibacillaceae	91061|Bacilli	O	5-oxoproline from various penultimate amino acid residues except L-proline	pcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564	3.4.19.3	ko:K01304	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C15
GDHHQS1_k127_9129290_14	370438.PTH_2653	2.918e-38	147.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,2629K@186807|Peptococcaceae	186801|Clostridia	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
GDHHQS1_k127_9129290_2	335543.Sfum_1683	2.369e-168	546.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MR0M@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
GDHHQS1_k127_9129290_15	1499967.BAYZ01000078_gene986	8.833e-37	144.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ACT
GDHHQS1_k127_9129290_3	1499967.BAYZ01000078_gene985	3.855e-165	531.0	COG1541@1|root,COG1541@2|Bacteria,2NREC@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
GDHHQS1_k127_9129290_10	247490.KSU1_C1464	5.242e-60	220.0	COG0053@1|root,COG0053@2|Bacteria,2IY05@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
GDHHQS1_k127_9129290_16	1306174.JODP01000001_gene4919	1.609e-17	96.0	COG1595@1|root,COG1595@2|Bacteria,2GMJS@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS1_k127_9129290_17	1283283.ATXA01000007_gene3967	3.117e-11	76.0	COG1536@1|root,COG1536@2|Bacteria,2GP1H@201174|Actinobacteria,4ES35@85013|Frankiales	201174|Actinobacteria	N	flagellar motor switch protein FliG	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
GDHHQS1_k127_9129290_9	1185876.BN8_06214	5.173e-79	276.0	COG2706@1|root,COG2706@2|Bacteria,4NE87@976|Bacteroidetes,47KQB@768503|Cytophagia	976|Bacteroidetes	G	PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
GDHHQS1_k127_9129290_0	584708.Apau_0592	2.493e-184	585.0	COG0017@1|root,COG0017@2|Bacteria,3T9TP@508458|Synergistetes	508458|Synergistetes	J	PFAM tRNA synthetase class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
GDHHQS1_k127_9129290_11	573413.Spirs_3148	3.144e-56	215.0	COG1536@1|root,COG1536@2|Bacteria,2J6EK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar motor switch protein	fliG-1	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
GDHHQS1_k127_9129290_13	1480694.DC28_07185	1.269e-46	184.0	2DBQ8@1|root,2ZACX@2|Bacteria,2J648@203691|Spirochaetes	203691|Spirochaetes	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
GDHHQS1_k127_9129290_1	158189.SpiBuddy_0934	1.048e-175	569.0	COG2509@1|root,COG2509@2|Bacteria,2J6ED@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Pyr_redox_2
GDHHQS1_k127_9129290_5	518766.Rmar_0474	6.001e-102	343.0	COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes	976|Bacteroidetes	G	Converts alpha-aldose to the beta-anomer	galM	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
GDHHQS1_k127_9129290_8	1499967.BAYZ01000123_gene2487	1.611e-88	301.0	COG1349@1|root,COG1349@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
GDHHQS1_k127_9129290_4	1499967.BAYZ01000032_gene1135	1.934e-164	529.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	-	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS1_k127_9138309_7	439481.Aboo_0779	1.072e-18	102.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03607@2157|Archaea	2157|Archaea	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,Big_3_5,NosD,PKD,Peptidase_C1,S_layer_C
GDHHQS1_k127_9138309_2	1185876.BN8_01058	2.29e-110	392.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
GDHHQS1_k127_9138309_4	889378.Spiaf_1383	4.534e-49	181.0	COG1678@1|root,COG1678@2|Bacteria	2|Bacteria	K	ribonucleoside-diphosphate reductase activity	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
GDHHQS1_k127_9138309_1	744872.Spica_1809	1.555e-125	419.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
GDHHQS1_k127_9138309_3	545694.TREPR_0271	6.484e-69	242.0	2EYA0@1|root,33RIG@2|Bacteria,2J6Q4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9138309_5	1347392.CCEZ01000049_gene1348	1.15e-46	177.0	COG0778@1|root,COG0778@2|Bacteria,1UZUV@1239|Firmicutes,24F6B@186801|Clostridia,36IIV@31979|Clostridiaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
GDHHQS1_k127_9138309_0	556261.HMPREF0240_00421	3.002e-240	773.0	COG1882@1|root,COG1882@2|Bacteria,1VTIM@1239|Firmicutes,24EPG@186801|Clostridia,36H8K@31979|Clostridiaceae	186801|Clostridia	C	Pyruvate formate lyase-like	-	-	-	-	-	-	-	-	-	-	-	-	Gly_radical,PFL-like
GDHHQS1_k127_9138309_8	556261.HMPREF0240_02336	1.905e-18	100.0	COG0407@1|root,COG0407@2|Bacteria,1VPBU@1239|Firmicutes,24IYJ@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_9138309_6	1121403.AUCV01000063_gene4196	1.898e-39	154.0	COG0500@1|root,COG0500@2|Bacteria,1QXX1@1224|Proteobacteria,43CRG@68525|delta/epsilon subdivisions	1224|Proteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
GDHHQS1_k127_9177901_0	1499967.BAYZ01000171_gene5567	0.0	1151.0	COG1148@1|root,COG4231@1|root,COG1148@2|Bacteria,COG4231@2|Bacteria	2|Bacteria	C	indolepyruvate ferredoxin oxidoreductase activity	bamE	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_20,Fer4_7,Pyr_redox_2
GDHHQS1_k127_9177901_1	1499967.BAYZ01000171_gene5566	1.086e-280	874.0	COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	bamH	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
GDHHQS1_k127_9177901_3	1499967.BAYZ01000171_gene5565	1.807e-118	392.0	COG1148@1|root,COG1905@1|root,COG1148@2|Bacteria,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	bamG	-	1.6.5.3,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00334,ko:K03388	ko00190,ko00680,ko01100,ko01120,ko01200,map00190,map00680,map01100,map01120,map01200	M00144,M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944,R11945	RC00011,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Fer4,NAD_binding_8,Pyr_redox_2,Response_reg
GDHHQS1_k127_9177901_7	1499967.BAYZ01000171_gene5564	4.322e-59	211.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	dld	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
GDHHQS1_k127_9177901_2	1499967.BAYZ01000171_gene5563	3.368e-142	464.0	COG0685@1|root,COG0685@2|Bacteria,2NQBB@2323|unclassified Bacteria	2|Bacteria	E	Methylenetetrahydrofolate reductase	metF3	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
GDHHQS1_k127_9177901_4	1499967.BAYZ01000171_gene5562	2.297e-103	344.0	COG4656@1|root,COG4656@2|Bacteria	2|Bacteria	C	electron transfer activity	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS18525	Complex1_51K,Fer4_10,MTHFR_C,RnfC_N,SLBB
GDHHQS1_k127_9177901_9	1499967.BAYZ01000171_gene5561	4.705e-23	104.0	COG1908@1|root,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
GDHHQS1_k127_9177901_6	1499967.BAYZ01000171_gene5560	5.21e-61	236.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_4,Fer4_6,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
GDHHQS1_k127_9177901_5	1499967.BAYZ01000171_gene5560	3.399e-98	336.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_4,Fer4_6,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
GDHHQS1_k127_9177901_8	1278307.KB907015_gene3540	1.244e-58	224.0	COG2114@1|root,COG2114@2|Bacteria,1P8ZU@1224|Proteobacteria,1S6BW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19
GDHHQS1_k127_9203870_4	665571.STHERM_c01070	1.093e-09	60.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
GDHHQS1_k127_9203870_3	1303518.CCALI_02156	7.332e-33	135.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759,ko:K08234	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
GDHHQS1_k127_9203870_0	697281.Mahau_1296	1.015e-88	307.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24FCZ@186801|Clostridia,42HY1@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
GDHHQS1_k127_9203870_2	349163.Acry_1591	5.737e-67	237.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2JZBT@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
GDHHQS1_k127_9203870_1	1307761.L21SP2_3480	9.048e-71	269.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9233564_4	1122214.AQWH01000006_gene2382	1.949e-22	100.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS1_k127_9233564_0	1227497.C491_09924	1.391e-74	263.0	COG0411@1|root,arCOG00925@2157|Archaea,2XSVZ@28890|Euryarchaeota,23S9V@183963|Halobacteria	183963|Halobacteria	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	livG4	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS1_k127_9233564_1	1125863.JAFN01000001_gene454	6.876e-71	255.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42N1A@68525|delta/epsilon subdivisions,2WJ6H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS1_k127_9233564_2	485913.Krac_4929	1.055e-33	136.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	mocA	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
GDHHQS1_k127_9233564_3	105559.Nwat_1162	2.231e-31	125.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,1S2XY@1236|Gammaproteobacteria,1WYES@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS1_k127_9291038_1	744872.Spica_2731	4.215e-139	458.0	COG1508@1|root,COG1508@2|Bacteria,2J5KV@203691|Spirochaetes	203691|Spirochaetes	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
GDHHQS1_k127_9291038_7	744872.Spica_2730	1.308e-20	96.0	COG1544@1|root,COG1544@2|Bacteria,2J8GG@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal subunit interface protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
GDHHQS1_k127_9291038_2	545695.TREAZ_1342	2.599e-135	447.0	COG1493@1|root,COG1493@2|Bacteria,2J5JA@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
GDHHQS1_k127_9291038_6	744872.Spica_2578	7.115e-29	117.0	COG1925@1|root,COG1925@2|Bacteria,2J8NY@203691|Spirochaetes	203691|Spirochaetes	G	phosphocarrier protein HPr	ptsH-2	-	-	ko:K02784,ko:K11189	ko02060,map02060	-	-	-	ko00000,ko00001,ko02000	4.A.2.1,8.A.8.1.1	-	-	PTS-HPr
GDHHQS1_k127_9291038_3	889378.Spiaf_2666	1.277e-122	422.0	COG5000@1|root,COG5000@2|Bacteria,2J753@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS1_k127_9291038_0	1123274.KB899414_gene3665	2.889e-152	520.0	COG2204@1|root,COG2204@2|Bacteria,2J63G@203691|Spirochaetes	203691|Spirochaetes	T	Regulatory protein	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GDHHQS1_k127_9291038_4	1307761.L21SP2_3290	2.556e-70	245.0	COG1974@1|root,COG1974@2|Bacteria,2J7ID@203691|Spirochaetes	203691|Spirochaetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
GDHHQS1_k127_9291038_5	573413.Spirs_4056	4.122e-68	243.0	COG1466@1|root,COG1466@2|Bacteria,2J6PN@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
GDHHQS1_k127_9320678_5	180332.JTGN01000004_gene2606	7.565e-45	164.0	COG0407@1|root,COG0407@2|Bacteria,1V4YU@1239|Firmicutes,24KSS@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
GDHHQS1_k127_9320678_4	1122918.KB907252_gene2845	8.399e-48	199.0	COG3210@1|root,COG4447@1|root,COG5184@1|root,COG3210@2|Bacteria,COG4447@2|Bacteria,COG5184@2|Bacteria,1UNKJ@1239|Firmicutes,4IUH9@91061|Bacilli,277M0@186822|Paenibacillaceae	91061|Bacilli	DUZ	Cadherin-like beta sandwich domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,SLH
GDHHQS1_k127_9320678_0	926550.CLDAP_16080	1.04e-124	413.0	COG1653@1|root,COG1653@2|Bacteria,2G958@200795|Chloroflexi	200795|Chloroflexi	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
GDHHQS1_k127_9320678_2	1449063.JMLS01000040_gene3913	5.139e-104	362.0	COG1653@1|root,COG1653@2|Bacteria,1UW8Q@1239|Firmicutes,4HT3V@91061|Bacilli,276NU@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
GDHHQS1_k127_9320678_3	935845.JADQ01000001_gene1105	1.752e-80	285.0	COG0395@1|root,COG0395@2|Bacteria,1UYBN@1239|Firmicutes,4HGDI@91061|Bacilli,26RN5@186822|Paenibacillaceae	91061|Bacilli	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_9320678_1	1291050.JAGE01000001_gene1797	9.845e-109	358.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,248XU@186801|Clostridia,3WHDQ@541000|Ruminococcaceae	186801|Clostridia	P	carbohydrate ABC transporter membrane protein 1 CUT1 family	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_9330224_13	395494.Galf_1779	6.739e-35	143.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,44VRD@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
GDHHQS1_k127_9330224_0	1123274.KB899415_gene2477	3.376e-290	920.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
GDHHQS1_k127_9330224_22	545695.TREAZ_2691	7.079e-08	65.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
GDHHQS1_k127_9330224_6	1195236.CTER_5299	7.157e-95	324.0	COG0493@1|root,COG0493@2|Bacteria,1V14A@1239|Firmicutes,24FJ4@186801|Clostridia,3WP0B@541000|Ruminococcaceae	186801|Clostridia	C	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4,Fer4_20
GDHHQS1_k127_9330224_1	906968.Trebr_0890	3.592e-169	542.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
GDHHQS1_k127_9330224_17	665571.STHERM_c10530	5.867e-26	109.0	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
GDHHQS1_k127_9330224_16	1123274.KB899415_gene2482	2.383e-29	118.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
GDHHQS1_k127_9330224_11	665571.STHERM_c10550	2.847e-43	163.0	COG0806@1|root,COG0806@2|Bacteria,2J73Y@203691|Spirochaetes	203691|Spirochaetes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
GDHHQS1_k127_9330224_7	906968.Trebr_0905	7.863e-85	292.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
GDHHQS1_k127_9330224_12	1480694.DC28_01850	1.547e-42	164.0	COG0335@1|root,COG0335@2|Bacteria,2J825@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
GDHHQS1_k127_9330224_21	1266909.AUAG01000011_gene1039	1.332e-10	66.0	COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,1SCWV@1236|Gammaproteobacteria,1WYU0@135613|Chromatiales	135613|Chromatiales	S	cytoplasmic domain of flagellar protein	-	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
GDHHQS1_k127_9330224_4	744872.Spica_0482	7.649e-106	360.0	COG2206@1|root,COG2206@2|Bacteria,2J6GF@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
GDHHQS1_k127_9330224_20	1217720.ALOX01000010_gene2063	2.028e-17	88.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2UFTM@28211|Alphaproteobacteria,2JU8R@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
GDHHQS1_k127_9330224_19	573413.Spirs_1882	1.577e-17	88.0	2EFYN@1|root,339QT@2|Bacteria,2J8BI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9330224_9	1123274.KB899415_gene2493	1.347e-49	186.0	COG1413@1|root,COG1413@2|Bacteria,2J61J@203691|Spirochaetes	203691|Spirochaetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
GDHHQS1_k127_9330224_15	889378.Spiaf_0833	1.36e-30	128.0	2FCY0@1|root,3437Z@2|Bacteria,2JBFD@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9330224_8	889378.Spiaf_1696	1.723e-53	194.0	COG0669@1|root,COG0669@2|Bacteria,2J7VS@203691|Spirochaetes	203691|Spirochaetes	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
GDHHQS1_k127_9330224_18	744872.Spica_1406	5.169e-21	93.0	COG0333@1|root,COG0333@2|Bacteria,2J8XR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
GDHHQS1_k127_9330224_14	665571.STHERM_c10660	3.296e-34	133.0	COG0236@1|root,COG0236@2|Bacteria,2J8CN@203691|Spirochaetes	203691|Spirochaetes	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
GDHHQS1_k127_9330224_5	573413.Spirs_1889	1.218e-95	321.0	COG0571@1|root,COG0571@2|Bacteria,2J6UI@203691|Spirochaetes	203691|Spirochaetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
GDHHQS1_k127_9330224_3	573413.Spirs_1890	5.216e-135	444.0	COG0617@1|root,COG1418@1|root,COG0617@2|Bacteria,COG1418@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
GDHHQS1_k127_9330224_2	665571.STHERM_c10690	5.374e-136	445.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N,Flg_bb_rod
GDHHQS1_k127_9330224_10	545694.TREPR_2686	1.432e-49	185.0	COG1564@1|root,COG1564@2|Bacteria,2J7RD@203691|Spirochaetes	203691|Spirochaetes	H	Thiamin pyrophosphokinase, catalytic domain	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
GDHHQS1_k127_9330224_23	1302858.I871_03695	0.0002907	53.0	297HH@1|root,2ZUQS@2|Bacteria,2JBB5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
GDHHQS1_k127_9379200_2	443143.GM18_0566	3.863e-15	90.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42Q3Z@68525|delta/epsilon subdivisions,2WJPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_2,CUB,He_PIG,Peptidase_S8
GDHHQS1_k127_9379200_0	720554.Clocl_1416	1.12e-171	549.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3WGVU@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
GDHHQS1_k127_9379200_1	580332.Slit_2626	2.087e-27	123.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VMB2@28216|Betaproteobacteria,44W3T@713636|Nitrosomonadales	28216|Betaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
GDHHQS1_k127_945148_1	794903.OPIT5_05280	6.951e-62	221.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,46UUR@74201|Verrucomicrobia,3K75F@414999|Opitutae	414999|Opitutae	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
GDHHQS1_k127_945148_0	573413.Spirs_2436	1.455e-124	416.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
GDHHQS1_k127_945148_3	485918.Cpin_6164	2.082e-21	103.0	2A1V7@1|root,30Q4D@2|Bacteria,4P3GP@976|Bacteroidetes,1IXY5@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_945148_2	28115.HR11_06730	3.444e-26	116.0	COG1226@1|root,COG1226@2|Bacteria,4NN0Z@976|Bacteroidetes,2G3EK@200643|Bacteroidia,2321Z@171551|Porphyromonadaceae	976|Bacteroidetes	P	Ion transport protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
GDHHQS1_k127_9479972_6	1304284.L21TH_2026	1.183e-32	134.0	COG0420@1|root,COG0420@2|Bacteria,1V3MP@1239|Firmicutes,24J4M@186801|Clostridia	186801|Clostridia	L	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
GDHHQS1_k127_9479972_0	593750.Metfor_2818	7.169e-118	400.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota	28890|Euryarchaeota	L	COG0863 DNA modification methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
GDHHQS1_k127_9479972_1	744872.Spica_1257	1.645e-108	383.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
GDHHQS1_k127_9479972_2	349741.Amuc_0958	1.424e-88	301.0	COG0708@1|root,COG0708@2|Bacteria,46TGT@74201|Verrucomicrobia,2IU1A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
GDHHQS1_k127_9479972_3	177437.HRM2_09660	2.291e-80	285.0	COG0697@1|root,COG2371@1|root,COG0697@2|Bacteria,COG2371@2|Bacteria,1N3FA@1224|Proteobacteria,42RW0@68525|delta/epsilon subdivisions,2WNEH@28221|Deltaproteobacteria,2MMWS@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS1_k127_9479972_5	1122221.JHVI01000004_gene147	1.257e-44	176.0	2CMS6@1|root,32SFE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
GDHHQS1_k127_9479972_7	517418.Ctha_2508	5.115e-30	123.0	COG3118@1|root,COG3118@2|Bacteria,1FE4C@1090|Chlorobi	1090|Chlorobi	O	Belongs to the thioredoxin family	-	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
GDHHQS1_k127_9479972_4	555079.Toce_0390	4.107e-67	232.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,42FYS@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD
GDHHQS1_k127_9503721_1	565034.BHWA1_01335	4.497e-28	119.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
GDHHQS1_k127_9503721_0	573413.Spirs_2373	5.611e-107	359.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	hoxI	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	EAL,FliG_C,HATPase_c,HisKA,cNMP_binding
GDHHQS1_k127_9534939_0	1125699.HMPREF9194_00527	1.657e-112	370.0	COG1123@1|root,COG4172@2|Bacteria,2J9MU@203691|Spirochaetes	203691|Spirochaetes	P	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
GDHHQS1_k127_9534939_1	1122917.KB899661_gene1006	8.134e-107	370.0	COG2972@1|root,COG2972@2|Bacteria,1V051@1239|Firmicutes,4HHCW@91061|Bacilli,26TRX@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase,dCache_1
GDHHQS1_k127_9534939_2	693986.MOC_4682	4.642e-80	275.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JSQZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF4118,HATPase_c,HisKA,PAS_7,Response_reg
GDHHQS1_k127_9566355_9	1123075.AUDP01000024_gene1090	6.912e-89	306.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes,24EHD@186801|Clostridia,3WKR9@541000|Ruminococcaceae	186801|Clostridia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
GDHHQS1_k127_9566355_4	697281.Mahau_2771	5.855e-104	357.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,42FX4@68295|Thermoanaerobacterales	1239|Firmicutes	G	PFAM glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
GDHHQS1_k127_9566355_11	158190.SpiGrapes_3031	1.353e-80	279.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
GDHHQS1_k127_9566355_10	697281.Mahau_1812	2.03e-83	288.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,24BR4@186801|Clostridia,42G9P@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator (RpiR family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
GDHHQS1_k127_9566355_3	926550.CLDAP_32450	1.194e-113	383.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	2|Bacteria	G	PFAM carbohydrate kinase	-	-	2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5	ko:K00848,ko:K00851,ko:K00854,ko:K00862	ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737,R01902,R03014,R11536	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS1_k127_9566355_0	553973.CLOHYLEM_06006	3.055e-162	522.0	COG4091@1|root,COG4091@2|Bacteria,1TR51@1239|Firmicutes,24AUF@186801|Clostridia,223VP@1506553|Lachnoclostridium	186801|Clostridia	E	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DapB_N,F420_oxidored,NAD_binding_3,SAF
GDHHQS1_k127_9566355_8	97139.C824_05382	2.851e-97	329.0	COG1063@1|root,COG1063@2|Bacteria,1V06H@1239|Firmicutes,25B5H@186801|Clostridia	186801|Clostridia	E	COG COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
GDHHQS1_k127_9566355_15	1219084.AP014508_gene908	2.036e-37	152.0	COG0395@1|root,COG0395@2|Bacteria,2GCRW@200918|Thermotogae	200918|Thermotogae	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS1_k127_9566355_14	697281.Mahau_2225	1.661e-51	195.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,24IYM@186801|Clostridia	186801|Clostridia	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
GDHHQS1_k127_9566355_17	160799.PBOR_28835	4.841e-18	98.0	COG1653@1|root,COG1653@2|Bacteria,1VSQ2@1239|Firmicutes,4IR6B@91061|Bacilli,26T70@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1,SBP_bac_8
GDHHQS1_k127_9566355_13	1232453.BAIF02000051_gene1044	8.483e-53	199.0	COG0794@1|root,COG0794@2|Bacteria,1TQ04@1239|Firmicutes,249KC@186801|Clostridia	186801|Clostridia	M	sugar phosphate isomerase involved in capsule formation	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
GDHHQS1_k127_9566355_12	525904.Tter_2870	5.319e-63	226.0	COG0704@1|root,COG0704@2|Bacteria,2NPWX@2323|unclassified Bacteria	2|Bacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
GDHHQS1_k127_9566355_6	335543.Sfum_0701	2.425e-103	347.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MR99@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
GDHHQS1_k127_9566355_5	335543.Sfum_0702	1.949e-103	356.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42NXP@68525|delta/epsilon subdivisions,2WK2A@28221|Deltaproteobacteria,2MRC2@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
GDHHQS1_k127_9566355_2	335543.Sfum_0703	1.022e-119	406.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
GDHHQS1_k127_9566355_1	335543.Sfum_0704	1.774e-128	418.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MQY5@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
GDHHQS1_k127_9566355_7	335543.Sfum_0705	2.936e-101	346.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
GDHHQS1_k127_9566355_16	71421.HI_0338	7.968e-32	130.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1Y7SV@135625|Pasteurellales	135625|Pasteurellales	S	UPF0118 membrane protein	tqsA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
GDHHQS1_k127_9704933_3	397291.C804_01235	1.858e-09	61.0	COG0546@1|root,COG0546@2|Bacteria,1V75Y@1239|Firmicutes,24DJG@186801|Clostridia,27R21@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
GDHHQS1_k127_9704933_2	1307761.L21SP2_1275	1.639e-68	244.0	COG5660@1|root,2Z7TM@2|Bacteria,2JBFN@203691|Spirochaetes	203691|Spirochaetes	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
GDHHQS1_k127_9704933_1	665571.STHERM_c20410	8.254e-73	257.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
GDHHQS1_k127_9704933_0	573413.Spirs_2249	2.689e-159	523.0	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,2J5NW@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
GDHHQS1_k127_9709047_3	643867.Ftrac_1681	1.239e-35	141.0	2CK4K@1|root,32QTB@2|Bacteria,4NQUN@976|Bacteroidetes,47WRQ@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
GDHHQS1_k127_9709047_1	643867.Ftrac_1682	1.369e-60	214.0	29X2E@1|root,30IQW@2|Bacteria,4P919@976|Bacteroidetes,47WI2@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
GDHHQS1_k127_9709047_0	1142394.PSMK_31760	5.767e-157	518.0	COG1874@1|root,COG1874@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHL6,Glyco_hydro_42M
GDHHQS1_k127_9709047_2	889378.Spiaf_0742	5.132e-58	208.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
GDHHQS1_k127_9709047_4	1307761.L21SP2_3186	1.576e-27	117.0	2C8AB@1|root,2ZW6G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9711353_0	760011.Spico_1067	2.251e-131	433.0	COG2211@1|root,COG2211@2|Bacteria,2JAUS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
GDHHQS1_k127_9733138_2	1120950.KB892797_gene2232	2.094e-28	121.0	COG0673@1|root,COG0673@2|Bacteria,2IBFN@201174|Actinobacteria,4DT7Z@85009|Propionibacteriales	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GDHHQS1_k127_9733138_1	158190.SpiGrapes_2198	4.241e-47	183.0	COG2197@1|root,COG2197@2|Bacteria,2JATP@203691|Spirochaetes	203691|Spirochaetes	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
GDHHQS1_k127_9733138_0	158190.SpiGrapes_2199	1.88e-113	376.0	COG2267@1|root,COG2267@2|Bacteria,2J8UY@203691|Spirochaetes	203691|Spirochaetes	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
GDHHQS1_k127_9733138_3	660470.Theba_2716	4.942e-15	88.0	COG0793@1|root,COG0793@2|Bacteria,2GDPT@200918|Thermotogae	200918|Thermotogae	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
GDHHQS1_k127_9739622_2	744872.Spica_1658	8.237e-113	369.0	COG4865@1|root,COG4865@2|Bacteria,2J6PW@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
GDHHQS1_k127_9739622_1	1124991.MU9_1023	1.476e-172	554.0	COG3799@1|root,COG3799@2|Bacteria,1MW90@1224|Proteobacteria,1RRUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Methylaspartate ammonia-lyase	-	-	4.3.1.2	ko:K04835	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R03696	RC00979	ko00000,ko00001,ko00002,ko01000	-	-	-	MAAL_C,MAAL_N
GDHHQS1_k127_9739622_0	744872.Spica_1660	9.905e-191	627.0	COG1574@1|root,COG1574@2|Bacteria,2J6CH@203691|Spirochaetes	203691|Spirochaetes	S	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
GDHHQS1_k127_9739622_4	744872.Spica_1661	2.036e-31	141.0	2CDKX@1|root,32RXZ@2|Bacteria,2J91F@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4387)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4387
GDHHQS1_k127_9739622_3	382464.ABSI01000010_gene3515	1.62e-37	163.0	2F006@1|root,33T46@2|Bacteria,46U4Y@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9781670_3	545694.TREPR_3813	4.15e-13	70.0	COG0613@1|root,COG0613@2|Bacteria,2J69S@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
GDHHQS1_k127_9781670_0	665571.STHERM_c07230	1.734e-82	284.0	COG0767@1|root,COG0767@2|Bacteria,2J7BX@203691|Spirochaetes	203691|Spirochaetes	Q	ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
GDHHQS1_k127_9781670_2	1123274.KB899428_gene1849	6.289e-58	210.0	COG1135@1|root,COG1135@2|Bacteria,2J7XY@203691|Spirochaetes	203691|Spirochaetes	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
GDHHQS1_k127_9781670_1	744872.Spica_2754	2.246e-79	279.0	COG1463@1|root,COG1463@2|Bacteria,2J7MR@203691|Spirochaetes	203691|Spirochaetes	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
GDHHQS1_k127_9797270_2	665571.STHERM_c20050	2.469e-128	434.0	COG4992@1|root,COG4992@2|Bacteria,2J5X2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS1_k127_9797270_8	665571.STHERM_c20040	5.86e-62	224.0	COG0548@1|root,COG0548@2|Bacteria,2J6RN@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
GDHHQS1_k127_9797270_4	665571.STHERM_c20030	3.202e-107	395.0	COG0002@1|root,COG0002@2|Bacteria,2J637@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
GDHHQS1_k127_9797270_11	1125725.HMPREF1325_0745	8.559e-38	148.0	COG1438@1|root,COG1438@2|Bacteria,2J7NJ@203691|Spirochaetes	203691|Spirochaetes	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
GDHHQS1_k127_9797270_15	663278.Ethha_0113	9.391e-15	83.0	2ERRQ@1|root,33JAW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9797270_0	1304880.JAGB01000003_gene1027	0.0	1230.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolases family 38 C-terminal domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
GDHHQS1_k127_9797270_10	1449126.JQKL01000037_gene2034	2.999e-38	163.0	COG1611@1|root,COG1611@2|Bacteria,1UKED@1239|Firmicutes,24DSN@186801|Clostridia	186801|Clostridia	L	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
GDHHQS1_k127_9797270_7	545694.TREPR_0902	1.645e-75	269.0	COG1801@1|root,COG1801@2|Bacteria,2J5GQ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
GDHHQS1_k127_9797270_9	644966.Tmar_1095	6.021e-58	216.0	COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,247Q4@186801|Clostridia	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GDHHQS1_k127_9797270_6	56780.SYN_00351	2.444e-78	276.0	COG1456@1|root,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,42NKF@68525|delta/epsilon subdivisions,2WJ72@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase delta subunit, TIM barrel	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
GDHHQS1_k127_9797270_12	768710.DesyoDRAFT_4237	4.13e-35	139.0	COG4231@1|root,COG4231@2|Bacteria,1VAJQ@1239|Firmicutes,24MVB@186801|Clostridia,262JW@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
GDHHQS1_k127_9797270_3	573061.Clocel_1239	1.827e-119	407.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36DEY@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_9797270_1	926569.ANT_22700	1.162e-227	719.0	COG1132@1|root,COG1132@2|Bacteria,2G7KA@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS1_k127_9797270_5	1304885.AUEY01000005_gene892	1.411e-88	311.0	COG0598@1|root,COG0598@2|Bacteria,1RGGI@1224|Proteobacteria,42UX4@68525|delta/epsilon subdivisions,2WQYH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Mg2 transporter protein CorA family protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
GDHHQS1_k127_9797270_13	1192034.CAP_8755	6.972e-24	104.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2WPAW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
GDHHQS1_k127_9819672_1	1480694.DC28_08650	2.218e-13	84.0	28XQQ@1|root,2ZJMD@2|Bacteria,2J8Q3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LptC
GDHHQS1_k127_9819672_0	1123274.KB899414_gene3655	1.728e-224	707.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
GDHHQS1_k127_9819672_2	545695.TREAZ_3270	1.005e-05	49.0	COG1692@1|root,COG1692@2|Bacteria,2J6ZK@203691|Spirochaetes	203691|Spirochaetes	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
GDHHQS1_k127_9828684_2	869209.Tresu_1241	6.916e-41	153.0	COG1559@1|root,COG1559@2|Bacteria,2J5V4@203691|Spirochaetes	203691|Spirochaetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
GDHHQS1_k127_9828684_0	889378.Spiaf_1500	3.993e-112	383.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
GDHHQS1_k127_9828684_1	744872.Spica_1392	5.764e-49	187.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS1_k127_9853679_1	665571.STHERM_c01810	3.681e-101	333.0	COG0147@1|root,COG0147@2|Bacteria,2J5PF@203691|Spirochaetes	203691|Spirochaetes	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
GDHHQS1_k127_9853679_0	665571.STHERM_c01820	9.704e-182	594.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,2J59H@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
GDHHQS1_k127_9853679_2	1480694.DC28_10225	1.166e-19	102.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,2J5XH@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	trpF	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
GDHHQS1_k127_9941807_1	665571.STHERM_c10360	1.241e-71	246.0	COG0029@1|root,COG0029@2|Bacteria,2JBD7@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
GDHHQS1_k127_9941807_0	613026.HRAG_00894	7.545e-90	313.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	cpdA	-	-	-	-	-	-	-	-	-	-	-	Metallophos
GDHHQS1_k127_9941807_2	706587.Desti_1456	1.039e-22	98.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
GDHHQS1_k127_9978666_1	573413.Spirs_2423	1.771e-31	143.0	2F8XC@1|root,34196@2|Bacteria,2J6EN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS1_k127_9978666_0	1123274.KB899419_gene1993	4.702e-113	376.0	COG0618@1|root,COG0618@2|Bacteria,2J74X@203691|Spirochaetes	203691|Spirochaetes	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
## 2648 queries scanned
## Total time (seconds): 48.97762417793274
## Rate: 54.07 q/s