## Mon Feb 16 19:53:10 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/GDHHQS2_bin.19.fa -m mmseqs --output GDHHQS2_bin.19 --output_dir /data/result/bins/wyx/eggqs50+/GDHHQS2_bin.19 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
GDHHQS2_k127_1009578_2	114615.BRADO7042	3.201e-33	136.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2U3N3@28211|Alphaproteobacteria,3JX7E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_1009578_0	479434.Sthe_3442	1.235e-146	470.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi,27XSM@189775|Thermomicrobia	2|Bacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
GDHHQS2_k127_1009578_1	1121926.AXWO01000031_gene2431	2.36e-97	324.0	COG1922@1|root,COG1922@2|Bacteria,2ICDG@201174|Actinobacteria,4EYRY@85014|Glycomycetales	201174|Actinobacteria	M	Glycosyl transferase WecB/TagA/CpsF family	rffM	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
GDHHQS2_k127_1009578_3	497964.CfE428DRAFT_0092	1.466e-19	96.0	2DDXY@1|root,2ZJRQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1009578_4	525909.Afer_0742	1.292e-09	61.0	COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4CN35@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_1024206_3	1304865.JAGF01000001_gene1127	0.0001516	48.0	COG1277@1|root,COG1277@2|Bacteria,2IMF1@201174|Actinobacteria	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
GDHHQS2_k127_1024206_0	1380347.JNII01000011_gene1032	1.1e-84	290.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4EUN8@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS2_k127_1024206_1	1996.JOFO01000015_gene983	4.043e-73	255.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4EGXW@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_1024206_2	1172188.KB911824_gene3379	1.184e-49	190.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4FH4A@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
GDHHQS2_k127_1026053_0	345341.KUTG_02737	1.544e-186	591.0	COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria,4DZMQ@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	1.2.1.18,1.2.1.27,2.6.1.19	ko:K00140,ko:K00823	ko00250,ko00280,ko00410,ko00562,ko00640,ko00650,ko01100,ko01120,ko01200,map00250,map00280,map00410,map00562,map00640,map00650,map01100,map01120,map01200	M00013,M00027	R00705,R00706,R00908,R00922,R00935,R01648	RC00004,RC00006,RC00062,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_1026053_3	1380350.JIAP01000008_gene2092	3.194e-30	123.0	2CWCM@1|root,32SZF@2|Bacteria,1N037@1224|Proteobacteria,2UCWU@28211|Alphaproteobacteria,43M44@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4260)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4260
GDHHQS2_k127_1026053_1	67267.JNXT01000021_gene6769	2.721e-151	481.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
GDHHQS2_k127_1026053_2	1380354.JIAN01000007_gene219	8.832e-127	414.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	thiY	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
GDHHQS2_k127_1026188_0	526227.Mesil_1713	1.804e-102	337.0	COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
GDHHQS2_k127_1026188_2	877424.ATWC01000052_gene694	1.042e-26	114.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,27NRG@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
GDHHQS2_k127_1026188_1	1125863.JAFN01000001_gene1971	1.667e-39	158.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria	1224|Proteobacteria	EM	Belongs to the DapA family	yagE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575	4.1.2.28,4.3.3.7	ko:K01714,ko:K22397	ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01782,R10147	RC00307,RC00572,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
GDHHQS2_k127_1027394_0	28444.JODQ01000007_gene5157	3.223e-72	265.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4EGMA@85012|Streptosporangiales	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
GDHHQS2_k127_1027394_1	1278073.MYSTI_04459	1.64e-24	107.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Fer4_9,PK,PK_C
GDHHQS2_k127_104494_1	1449355.JQNR01000005_gene5715	6.912e-09	59.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_CG,NAD_kinase
GDHHQS2_k127_104494_0	1205910.B005_5593	5.237e-73	267.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4EGSE@85012|Streptosporangiales	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
GDHHQS2_k127_1061294_0	35754.JNYJ01000014_gene4737	6.527e-112	378.0	COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DCJ0@85008|Micromonosporales	201174|Actinobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS2_k127_1068105_3	1380356.JNIK01000005_gene902	6.268e-54	206.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EU51@85013|Frankiales	201174|Actinobacteria	V	ABC transporter, transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
GDHHQS2_k127_1068105_0	1380356.JNIK01000005_gene901	3.22e-151	498.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EUMQ@85013|Frankiales	201174|Actinobacteria	V	ABC transporter, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
GDHHQS2_k127_1068105_1	1121370.AQUY01000002_gene1846	3.555e-72	253.0	COG1120@1|root,COG1120@2|Bacteria,2I5PA@201174|Actinobacteria	201174|Actinobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
GDHHQS2_k127_1068105_4	1313172.YM304_21830	1.027e-22	106.0	COG0735@1|root,COG0735@2|Bacteria,2HGFN@201174|Actinobacteria,4CND6@84992|Acidimicrobiia	84992|Acidimicrobiia	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
GDHHQS2_k127_1068105_2	1404245.CGLY_01880	3.064e-61	224.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,22RDP@1653|Corynebacteriaceae	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	mntC	-	-	ko:K02077	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
GDHHQS2_k127_1087306_0	525909.Afer_0633	1.564e-129	428.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
GDHHQS2_k127_1087306_1	67373.JOBF01000003_gene213	5.843e-37	148.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
GDHHQS2_k127_1087306_2	1120934.KB894408_gene4681	3.277e-12	71.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4DXAV@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Peptidase family M50	rip1	GO:0008150,GO:0040007	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
GDHHQS2_k127_1091072_1	1068980.ARVW01000001_gene6498	5.176e-72	258.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_1091072_0	1313172.YM304_31610	3.606e-79	271.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4CMX9@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_1091072_2	2045.KR76_26370	1.042e-37	144.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4DQQD@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
GDHHQS2_k127_1106036_1	314345.SPV1_00607	1.188e-18	88.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	yggU	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
GDHHQS2_k127_1106036_0	1121033.AUCF01000004_gene4671	3.027e-86	297.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,2TUAH@28211|Alphaproteobacteria,2JR0N@204441|Rhodospirillales	204441|Rhodospirillales	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
GDHHQS2_k127_1106036_2	1121272.KB903249_gene1590	7.677e-15	79.0	COG0517@1|root,COG0517@2|Bacteria,2I36Y@201174|Actinobacteria,4DMK8@85008|Micromonosporales	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
GDHHQS2_k127_1110509_1	1382356.JQMP01000001_gene1146	2.082e-15	83.0	COG0683@1|root,COG0683@2|Bacteria,2G7TX@200795|Chloroflexi,27YY0@189775|Thermomicrobia	189775|Thermomicrobia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
GDHHQS2_k127_1110509_0	1122609.AUGT01000030_gene2524	3.703e-30	124.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria	201174|Actinobacteria	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
GDHHQS2_k127_1115567_1	136273.GY22_14085	1.737e-06	56.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,1W7S3@1268|Micrococcaceae	201174|Actinobacteria	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
GDHHQS2_k127_1115567_0	1095767.CAHD01000234_gene2783	4.368e-31	136.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria,4F13C@85016|Cellulomonadaceae	201174|Actinobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
GDHHQS2_k127_1124322_1	926550.CLDAP_00810	3.467e-70	241.0	COG1117@1|root,COG1117@2|Bacteria,2G646@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
GDHHQS2_k127_1124322_0	316274.Haur_3999	1.633e-129	424.0	COG0581@1|root,COG0581@2|Bacteria,2G6BI@200795|Chloroflexi,374ZR@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
GDHHQS2_k127_1125081_0	483219.LILAB_33810	5.306e-07	62.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
GDHHQS2_k127_1126477_1	278963.ATWD01000001_gene2834	3.207e-44	168.0	COG0521@1|root,COG0521@2|Bacteria,3Y504@57723|Acidobacteria,2JJI8@204432|Acidobacteriia	204432|Acidobacteriia	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
GDHHQS2_k127_1126477_0	644966.Tmar_1526	4.581e-67	246.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,3WDEV@538999|Clostridiales incertae sedis	186801|Clostridia	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
GDHHQS2_k127_1126477_2	1038860.AXAP01000001_gene6476	6.475e-30	128.0	COG3427@1|root,COG3427@2|Bacteria,1N4EQ@1224|Proteobacteria,2UJUX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	-	-	-	-	-	-	-	-	-	COXG
GDHHQS2_k127_1127606_1	1003195.SCAT_3359	8.359e-89	297.0	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria	201174|Actinobacteria	L	Transposase and inactivated derivatives IS30 family	-	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_38,rve
GDHHQS2_k127_1127606_3	1392491.JIAE01000001_gene2418	2.987e-36	146.0	COG1215@1|root,COG1215@2|Bacteria,1UK60@1239|Firmicutes,24IGY@186801|Clostridia,3WR5X@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GDHHQS2_k127_1127606_0	1123024.AUII01000005_gene2244	5.498e-140	460.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4DXQW@85010|Pseudonocardiales	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
GDHHQS2_k127_1127606_4	526225.Gobs_4297	1.217e-07	55.0	COG2835@1|root,COG2835@2|Bacteria,2HUT6@201174|Actinobacteria,4ETHY@85013|Frankiales	201174|Actinobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
GDHHQS2_k127_1127606_2	929712.KI912613_gene2888	1.015e-43	173.0	COG2222@1|root,COG2222@2|Bacteria,2IN5A@201174|Actinobacteria,4CP71@84995|Rubrobacteria	84995|Rubrobacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
GDHHQS2_k127_1135857_2	1229780.BN381_80403	4.933e-68	235.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,3UWH0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
GDHHQS2_k127_1135857_0	264732.Moth_0263	8.343e-122	411.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
GDHHQS2_k127_1135857_1	1298863.AUEP01000014_gene1630	6.46e-79	273.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4DU7C@85009|Propionibacteriales	201174|Actinobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	wecE	-	2.6.1.59	ko:K02805	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	DegT_DnrJ_EryC1
GDHHQS2_k127_1153378_0	1370121.AUWS01000020_gene6686	1.546e-150	487.0	COG0074@1|root,COG0074@2|Bacteria,2GMFI@201174|Actinobacteria,234MN@1762|Mycobacteriaceae	201174|Actinobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,DUF1116,Ligase_CoA
GDHHQS2_k127_1153378_1	555778.Hneap_0794	4.146e-118	394.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RR0P@1236|Gammaproteobacteria,1X0E3@135613|Chromatiales	135613|Chromatiales	E	PFAM glutamine synthetase catalytic region	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
GDHHQS2_k127_1153378_2	309801.trd_1319	1.465e-60	216.0	COG2129@1|root,COG2129@2|Bacteria,2G7X0@200795|Chloroflexi	200795|Chloroflexi	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_118454_0	1123368.AUIS01000007_gene2706	4.326e-318	985.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,2NC9Q@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
GDHHQS2_k127_1188629_0	479433.Caci_7428	1.258e-98	335.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_1188629_1	710696.Intca_3046	2.296e-80	280.0	COG1105@1|root,COG1105@2|Bacteria	2|Bacteria	H	Belongs to the carbohydrate kinase PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
GDHHQS2_k127_1195307_0	58123.JOFJ01000005_gene1307	4.775e-105	351.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4EGAZ@85012|Streptosporangiales	201174|Actinobacteria	L	ATP dependent DNA ligase domain	ligC	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
GDHHQS2_k127_1195307_4	1487953.JMKF01000022_gene2512	3.967e-25	115.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
GDHHQS2_k127_1195307_2	743718.Isova_1947	1.959e-76	269.0	COG1609@1|root,COG1609@2|Bacteria,2GJRG@201174|Actinobacteria,4F3IB@85017|Promicromonosporaceae	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
GDHHQS2_k127_1195307_1	926550.CLDAP_04710	3.747e-82	290.0	COG2182@1|root,COG2182@2|Bacteria,2G91A@200795|Chloroflexi	200795|Chloroflexi	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
GDHHQS2_k127_1203599_2	36809.MAB_4842	3.779e-14	76.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,2352Q@1762|Mycobacteriaceae	201174|Actinobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
GDHHQS2_k127_1203599_1	1313172.YM304_06830	1.019e-51	190.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2IB1N@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LMWPc
GDHHQS2_k127_1203599_0	1229780.BN381_130089	6.595e-222	707.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,3UWBN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
GDHHQS2_k127_1203754_0	1382356.JQMP01000001_gene827	5.24e-117	389.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27Y34@189775|Thermomicrobia	189775|Thermomicrobia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_1203754_1	1123288.SOV_3c08530	1.024e-113	376.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,4H2HM@909932|Negativicutes	909932|Negativicutes	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
GDHHQS2_k127_1205215_3	1118054.CAGW01000061_gene2541	1.618e-54	201.0	COG1277@1|root,COG1277@2|Bacteria,1TQM9@1239|Firmicutes,4HDI1@91061|Bacilli,26U85@186822|Paenibacillaceae	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
GDHHQS2_k127_1205215_2	2045.KR76_16250	7.291e-61	218.0	COG1765@1|root,COG1765@2|Bacteria,2IE9R@201174|Actinobacteria,4DQXP@85009|Propionibacteriales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
GDHHQS2_k127_1205215_0	1337936.IJ00_09725	5.691e-222	695.0	COG2873@1|root,COG2873@2|Bacteria,1G4EH@1117|Cyanobacteria,1HINV@1161|Nostocales	1117|Cyanobacteria	E	Cys/Met metabolism PLP-dependent enzyme	met17	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
GDHHQS2_k127_1205215_1	1396418.BATQ01000133_gene4023	1.475e-112	375.0	COG2021@1|root,COG2021@2|Bacteria,46U58@74201|Verrucomicrobia,2ITGZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
GDHHQS2_k127_1205215_4	2002.JOEQ01000004_gene3101	1.776e-17	92.0	2BWH2@1|root,2Z89R@2|Bacteria,2GMNW@201174|Actinobacteria,4EI44@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
GDHHQS2_k127_1210269_4	1229780.BN381_350120	8.544e-05	47.0	COG2337@1|root,COG2337@2|Bacteria,2ISBP@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	mazF3	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045927,GO:0045934,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
GDHHQS2_k127_1210269_1	525904.Tter_1033	8.101e-87	303.0	COG0482@1|root,COG0482@2|Bacteria,2NNPW@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
GDHHQS2_k127_1210269_2	471853.Bcav_2773	1.163e-80	284.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria	201174|Actinobacteria	E	Cysteine desulfurase	iscS1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
GDHHQS2_k127_1210269_3	1121877.JQKF01000010_gene708	1.946e-29	123.0	COG3427@1|root,COG3427@2|Bacteria,2HGAK@201174|Actinobacteria,4CNA2@84992|Acidimicrobiia	84992|Acidimicrobiia	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
GDHHQS2_k127_1210269_0	246197.MXAN_1322	2.508e-111	374.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria	1224|Proteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
GDHHQS2_k127_1218058_0	1120983.KB894571_gene2480	1.003e-141	463.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JPCC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
GDHHQS2_k127_1218058_1	1380347.JNII01000009_gene2004	1.743e-19	98.0	COG1073@1|root,COG1073@2|Bacteria,2GNST@201174|Actinobacteria,4EU2M@85013|Frankiales	201174|Actinobacteria	S	Belongs to the UPF0255 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100,Hydrolase_4
GDHHQS2_k127_1219269_0	58123.JOFJ01000001_gene3296	1.768e-90	309.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4EHK1@85012|Streptosporangiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS2_k127_1219269_2	1123065.ATWL01000005_gene1203	1.947e-18	88.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	-	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
GDHHQS2_k127_1219269_1	1089550.ATTH01000001_gene166	4.719e-84	289.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,4NDWV@976|Bacteroidetes,1FJJA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglucose isomerase	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
GDHHQS2_k127_1220441_2	211586.SO_0462	4.19e-06	49.0	2CX7C@1|root,32T1D@2|Bacteria,1N2N3@1224|Proteobacteria,1S4YA@1236|Gammaproteobacteria,2QCAH@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1220441_0	68219.JNXI01000002_gene4170	7.784e-101	342.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
GDHHQS2_k127_1220441_1	867903.ThesuDRAFT_01782	3.316e-13	71.0	COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,24KZ9@186801|Clostridia,3WDN6@538999|Clostridiales incertae sedis	186801|Clostridia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_1241433_2	667014.Thein_0437	2.605e-11	66.0	COG0770@1|root,COG0770@2|Bacteria,2GH0Z@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
GDHHQS2_k127_1241433_0	656024.FsymDg_3117	5.884e-89	316.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
GDHHQS2_k127_1241433_3	110319.CF8_2678	0.0003759	49.0	COG2919@1|root,COG2919@2|Bacteria,2GW5Q@201174|Actinobacteria,4DS2Z@85009|Propionibacteriales	201174|Actinobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1241433_1	1356854.N007_01065	1.643e-34	135.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H9U2@91061|Bacilli,2797Y@186823|Alicyclobacillaceae	91061|Bacilli	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
GDHHQS2_k127_1242789_4	290397.Adeh_2502	5.273e-44	166.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2WP65@28221|Deltaproteobacteria,2YVJK@29|Myxococcales	28221|Deltaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
GDHHQS2_k127_1242789_2	765420.OSCT_2199	1.556e-86	306.0	COG1079@1|root,COG1079@2|Bacteria,2G6CY@200795|Chloroflexi,377XG@32061|Chloroflexia	32061|Chloroflexia	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS2_k127_1242789_3	1125863.JAFN01000001_gene149	1.04e-85	297.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42MWE@68525|delta/epsilon subdivisions,2WKIZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
GDHHQS2_k127_1242789_0	864702.OsccyDRAFT_1800	2.439e-127	430.0	COG3845@1|root,COG3845@2|Bacteria,1G4UA@1117|Cyanobacteria,1HH79@1150|Oscillatoriales	1117|Cyanobacteria	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
GDHHQS2_k127_1242789_1	765420.OSCT_2196	6.856e-123	401.0	COG1744@1|root,COG1744@2|Bacteria,2G6CN@200795|Chloroflexi	200795|Chloroflexi	M	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
GDHHQS2_k127_124600_4	1160137.KB907307_gene1257	1.14e-07	55.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4FVJ3@85025|Nocardiaceae	201174|Actinobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
GDHHQS2_k127_124600_1	1229780.BN381_350095	1.244e-30	130.0	COG0526@1|root,COG0526@2|Bacteria,2H8ZP@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_124600_3	649639.Bcell_2998	1.437e-28	121.0	COG1495@1|root,COG1495@2|Bacteria,1V79S@1239|Firmicutes,4HH9B@91061|Bacilli,1ZRVX@1386|Bacillus	91061|Bacilli	O	Required for disulfide bond formation in some proteins	bdbC	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
GDHHQS2_k127_124600_0	1128421.JAGA01000003_gene2807	1.055e-36	148.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	-	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	-
GDHHQS2_k127_124600_2	1298863.AUEP01000012_gene3783	1.301e-29	132.0	COG2021@1|root,COG2021@2|Bacteria,2I3M2@201174|Actinobacteria,4DQ5Q@85009|Propionibacteriales	201174|Actinobacteria	E	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
GDHHQS2_k127_1247058_2	1090319.KE386571_gene811	1.206e-07	56.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TRE4@28211|Alphaproteobacteria,2K22C@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,N6_N4_Mtase
GDHHQS2_k127_1247058_1	477974.Daud_0708	3.846e-24	103.0	COG2189@1|root,COG2189@2|Bacteria,1TR8A@1239|Firmicutes,249A1@186801|Clostridia,26567@186807|Peptococcaceae	186801|Clostridia	H	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
GDHHQS2_k127_1251521_2	1123507.ATVQ01000001_gene1614	1.077e-30	131.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,1W8W9@1268|Micrococcaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
GDHHQS2_k127_1251521_0	1144310.PMI07_005341	4.771e-148	481.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,4BBRG@82115|Rhizobiaceae	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
GDHHQS2_k127_1251521_1	2055.JNXA01000005_gene329	2.31e-117	392.0	COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4GA8D@85026|Gordoniaceae	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS2_k127_1251521_4	1003200.AXXA_09798	0.0006436	46.0	COG0697@1|root,COG0697@2|Bacteria,1PB22@1224|Proteobacteria,2VYG5@28216|Betaproteobacteria,3T43I@506|Alcaligenaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS2_k127_1258388_0	1150864.MILUP08_46690	2.794e-65	237.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4D9EZ@85008|Micromonosporales	201174|Actinobacteria	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
GDHHQS2_k127_1268483_1	1449347.JQLN01000004_gene6628	1.49e-21	101.0	COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria,2M15D@2063|Kitasatospora	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
GDHHQS2_k127_1268483_0	1229780.BN381_290109	8.963e-110	372.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,3UW6G@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
GDHHQS2_k127_1273919_1	1385517.N800_00445	3.99e-19	93.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1PH1W@1224|Proteobacteria,1RRYP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Metallo-peptidase family M12	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,P_proprotein,Reprolysin_3,Reprolysin_4
GDHHQS2_k127_1273919_0	502025.Hoch_1969	4.667e-133	436.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MJD@68525|delta/epsilon subdivisions,2WJC4@28221|Deltaproteobacteria,2YXYZ@29|Myxococcales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	epsN	-	2.6.1.102	ko:K13010,ko:K19430	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
GDHHQS2_k127_1277298_0	1125863.JAFN01000001_gene1711	3.969e-174	562.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
GDHHQS2_k127_1277298_2	1229780.BN381_210111	7.758e-09	65.0	2C8AG@1|root,33SQR@2|Bacteria,2H3BF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1277298_1	1203632.HMPREF1300_01143	9e-48	182.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,22K2D@1653|Corynebacteriaceae	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
GDHHQS2_k127_1288139_1	378806.STAUR_6520	7.508e-06	57.0	COG1840@1|root,COG1840@2|Bacteria,1QX5Y@1224|Proteobacteria,42PKC@68525|delta/epsilon subdivisions,2WISI@28221|Deltaproteobacteria,2YVGT@29|Myxococcales	28221|Deltaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
GDHHQS2_k127_1288139_0	35754.JNYJ01000005_gene5498	2.214e-72	253.0	COG2304@1|root,COG2304@2|Bacteria,2GNSN@201174|Actinobacteria,4D9P9@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	SBP_bac_11,VWA,VWA_2
GDHHQS2_k127_1291579_0	1382356.JQMP01000003_gene1605	6.04e-89	299.0	COG0209@1|root,COG0209@2|Bacteria,2G8RN@200795|Chloroflexi,27Y2V@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
GDHHQS2_k127_1291579_1	1123023.JIAI01000001_gene7780	6.037e-56	209.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053,ko:K02352	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
GDHHQS2_k127_1294136_0	1381123.AYOD01000035_gene3371	1.003e-137	449.0	COG3118@1|root,COG3118@2|Bacteria,1PQ8G@1224|Proteobacteria,2U0PC@28211|Alphaproteobacteria,43HR6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
GDHHQS2_k127_1294136_1	861299.J421_2134	9.035e-97	329.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	socC	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS2_k127_1301926_8	525904.Tter_0472	5.363e-05	51.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,2NQ1B@2323|unclassified Bacteria	2|Bacteria	M	MobA-like NTP transferase domain	spsI	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0016780	2.7.7.74,2.7.8.34	ko:K07281,ko:K07291	ko00562,map00562	-	R09669,R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,NTP_transf_3
GDHHQS2_k127_1301926_4	1229780.BN381_50175	3.024e-47	181.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,3UXIQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
GDHHQS2_k127_1301926_3	1122622.ATWJ01000010_gene1146	5.035e-57	212.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4FEF1@85021|Intrasporangiaceae	201174|Actinobacteria	M	GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
GDHHQS2_k127_1301926_0	1341151.ASZU01000008_gene1338	8.336e-130	429.0	COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,4H9RA@91061|Bacilli,27B8Z@186824|Thermoactinomycetaceae	91061|Bacilli	H	SOR/SNZ family	pdxS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
GDHHQS2_k127_1301926_2	1408452.JAGZ01000002_gene4651	1.582e-62	223.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,232VX@1762|Mycobacteriaceae	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
GDHHQS2_k127_1301926_1	572547.Amico_0867	1.334e-70	246.0	COG0217@1|root,COG0217@2|Bacteria,3T9QN@508458|Synergistetes	508458|Synergistetes	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
GDHHQS2_k127_1301926_5	1380347.JNII01000008_gene4106	7.517e-41	157.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4ESJZ@85013|Frankiales	201174|Actinobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
GDHHQS2_k127_1301926_6	1121940.AUDZ01000005_gene1883	2.42e-36	149.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1XJI5@135619|Oceanospirillales	135619|Oceanospirillales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
GDHHQS2_k127_1301926_7	247490.KSU1_B0670	1.38e-05	49.0	COG2255@1|root,COG2255@2|Bacteria,2IXY1@203682|Planctomycetes	203682|Planctomycetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
GDHHQS2_k127_1303859_1	675635.Psed_3296	3.467e-108	357.0	COG3383@1|root,COG3383@2|Bacteria,2GKBP@201174|Actinobacteria,4DXFK@85010|Pseudonocardiales	201174|Actinobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
GDHHQS2_k127_1303859_0	1120948.KB903225_gene5523	6.173e-162	520.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4E076@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
GDHHQS2_k127_130432_0	555088.DealDRAFT_1088	2.32e-40	158.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24G53@186801|Clostridia,42JVS@68298|Syntrophomonadaceae	186801|Clostridia	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_130432_1	266117.Rxyl_0159	4.01e-29	121.0	COG4585@1|root,COG4585@2|Bacteria,2GJKG@201174|Actinobacteria,4CQ9Z@84995|Rubrobacteria	84995|Rubrobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
GDHHQS2_k127_1311392_3	1306174.JODP01000009_gene6415	2.222e-56	211.0	COG1940@1|root,COG1940@2|Bacteria,2GZ27@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
GDHHQS2_k127_1311392_0	316274.Haur_1180	1.334e-135	447.0	COG1653@1|root,COG1653@2|Bacteria,2G8AR@200795|Chloroflexi,376NE@32061|Chloroflexia	32061|Chloroflexia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
GDHHQS2_k127_1311392_2	889378.Spiaf_2495	1.501e-87	302.0	COG1175@1|root,COG1175@2|Bacteria,2J5SW@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10233	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
GDHHQS2_k127_1311392_1	118168.MC7420_8015	3.094e-115	380.0	COG0395@1|root,COG0395@2|Bacteria,1G2TR@1117|Cyanobacteria,1H9ME@1150|Oscillatoriales	1117|Cyanobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
GDHHQS2_k127_1311392_4	324602.Caur_1110	2.761e-33	136.0	COG1472@1|root,COG1472@2|Bacteria,2G8JU@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 3 domain protein	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
GDHHQS2_k127_1311906_1	1045009.AFXQ01000007_gene2882	4.162e-11	69.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,1W8W9@1268|Micrococcaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
GDHHQS2_k127_1311906_0	1463855.JOHV01000046_gene228	4.775e-79	269.0	COG1116@1|root,COG1116@2|Bacteria,2GM73@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
GDHHQS2_k127_1319765_0	1380354.JIAN01000005_gene1521	1.494e-31	141.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
GDHHQS2_k127_1319765_1	1280390.CBQR020000096_gene2168	2.834e-20	106.0	COG0366@1|root,COG1621@1|root,COG5492@1|root,COG0366@2|Bacteria,COG1621@2|Bacteria,COG5492@2|Bacteria,1UIVZ@1239|Firmicutes,4ISU2@91061|Bacilli,277AE@186822|Paenibacillaceae	91061|Bacilli	GN	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Alpha-amylase,Gram_pos_anchor,PUD,SLH,YSIRK_signal
GDHHQS2_k127_1319765_2	1229780.BN381_420015	3.507e-08	56.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,3UX27@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	spoU2	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
GDHHQS2_k127_1319969_0	1541065.JRFE01000015_gene416	7.376e-147	487.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1G0GR@1117|Cyanobacteria,3VI61@52604|Pleurocapsales	1117|Cyanobacteria	E	Glycine cleavage system T protein	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
GDHHQS2_k127_1321610_0	448385.sce8234	1.336e-40	158.0	COG0791@1|root,COG3757@1|root,COG0791@2|Bacteria,COG3757@2|Bacteria	2|Bacteria	M	lysozyme activity	ps461	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	CW_7,Glyco_hydro_25,LysM,PG_binding_1,Peptidase_M23
GDHHQS2_k127_1339921_0	1121468.AUBR01000045_gene1800	9.139e-58	203.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,42FI5@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
GDHHQS2_k127_1345405_1	1172188.KB911823_gene513	1.995e-58	213.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4FFKZ@85021|Intrasporangiaceae	201174|Actinobacteria	S	Carboxylate--amine ligase	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
GDHHQS2_k127_1345405_0	1121877.JQKF01000003_gene1502	7.62e-69	240.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4CN01@84992|Acidimicrobiia	84992|Acidimicrobiia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
GDHHQS2_k127_1347774_0	861299.J421_4466	1.866e-80	277.0	COG0153@1|root,COG0153@2|Bacteria,1ZU6F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Belongs to the GHMP kinase family	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
GDHHQS2_k127_1347774_1	349124.Hhal_1643	5.998e-31	133.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T423@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
GDHHQS2_k127_1358554_2	1122165.AUHS01000003_gene1982	7.431e-10	61.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1JEBZ@118969|Legionellales	118969|Legionellales	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
GDHHQS2_k127_1358554_1	570952.ATVH01000017_gene1626	1.388e-29	132.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,2JQMA@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,SSF
GDHHQS2_k127_1358554_0	477974.Daud_1115	8.797e-172	573.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0182	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
GDHHQS2_k127_1358933_1	1196029.ALIM01000035_gene2289	4.556e-17	92.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HEC8@91061|Bacilli,1ZDXR@1386|Bacillus	91061|Bacilli	M	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SLH
GDHHQS2_k127_1358933_0	1260251.SPISAL_07325	3.928e-259	809.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales	135613|Chromatiales	P	PUA-like domain	-	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
GDHHQS2_k127_1358933_2	765912.Thimo_1150	4.284e-06	53.0	COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXUN@135613|Chromatiales	135613|Chromatiales	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
GDHHQS2_k127_1364012_1	1068980.ARVW01000001_gene3569	4.582e-51	185.0	COG1335@1|root,COG1335@2|Bacteria,2IG6Q@201174|Actinobacteria,4E2WN@85010|Pseudonocardiales	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
GDHHQS2_k127_1364012_0	1123257.AUFV01000003_gene1066	0.0	1197.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales	135614|Xanthomonadales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
GDHHQS2_k127_1365894_1	1185876.BN8_00646	6.719e-14	84.0	COG0739@1|root,COG0739@2|Bacteria,4NEBZ@976|Bacteroidetes,47JJ1@768503|Cytophagia	976|Bacteroidetes	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SH3_3,SH3_4
GDHHQS2_k127_1365894_0	469383.Cwoe_5918	4.981e-34	141.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
GDHHQS2_k127_1369107_1	1122611.KB903996_gene7507	1.393e-19	89.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4EFP2@85012|Streptosporangiales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
GDHHQS2_k127_1369107_0	644283.Micau_5428	1.227e-112	369.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4D8HC@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
GDHHQS2_k127_1370574_1	304371.MCP_1382	4.886e-33	136.0	COG2195@1|root,arCOG12582@2157|Archaea	2157|Archaea	E	tripeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1385074_2	1229780.BN381_110083	1.812e-36	146.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DLH
GDHHQS2_k127_1385074_1	330214.NIDE1188	1.338e-47	175.0	COG2258@1|root,COG2258@2|Bacteria	2|Bacteria	C	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
GDHHQS2_k127_1385074_0	1121272.KB903251_gene899	1.066e-230	728.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4DAKS@85008|Micromonosporales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
GDHHQS2_k127_1385074_3	1280390.CBQR020000102_gene2519	0.0003982	46.0	COG1846@1|root,COG1846@2|Bacteria,1V7G6@1239|Firmicutes,4HM9I@91061|Bacilli,26XQ9@186822|Paenibacillaceae	91061|Bacilli	K	MarR family transcriptional regulator	-	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
GDHHQS2_k127_1389898_4	1040986.ATYO01000001_gene1746	8.566e-10	63.0	COG0747@1|root,COG0747@2|Bacteria,1MXB1@1224|Proteobacteria,2U12E@28211|Alphaproteobacteria,43N6I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS2_k127_1389898_3	1382306.JNIM01000001_gene2342	6.809e-13	78.0	2C6H9@1|root,2ZQWJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1389898_1	1229172.JQFA01000002_gene2280	1.466e-23	109.0	COG3221@1|root,COG3221@2|Bacteria,1G2KS@1117|Cyanobacteria,1HFF5@1150|Oscillatoriales	1117|Cyanobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
GDHHQS2_k127_1389898_0	1123023.JIAI01000009_gene1181	1.054e-95	327.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria	2|Bacteria	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_1389898_2	926550.CLDAP_16610	4.493e-23	102.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2G5VA@200795|Chloroflexi	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	1.5.3.1,2.1.2.10	ko:K00303,ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R00610,R01221,R02300,R04125	RC00022,RC00060,RC00069,RC00183,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
GDHHQS2_k127_1414259_2	477641.MODMU_1311	8.929e-11	71.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
GDHHQS2_k127_1414259_1	1121877.JQKF01000009_gene498	7.018e-181	572.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
GDHHQS2_k127_1414259_0	264732.Moth_2105	2.261e-221	697.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,42EXT@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
GDHHQS2_k127_1419374_1	43228.XP_007737153.1	1.051e-38	147.0	COG0800@1|root,2RYBC@2759|Eukaryota,3A200@33154|Opisthokonta,3P2VX@4751|Fungi,3QUJT@4890|Ascomycota,20H4X@147545|Eurotiomycetes	4751|Fungi	E	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
GDHHQS2_k127_1419374_0	1121272.KB903251_gene842	5.28e-85	290.0	COG0332@1|root,COG0332@2|Bacteria,2GJSE@201174|Actinobacteria,4DIBB@85008|Micromonosporales	201174|Actinobacteria	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C,Haem_oxygenas_2
GDHHQS2_k127_1425032_0	1313172.YM304_21490	7.923e-258	806.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4CMWE@84992|Acidimicrobiia	84992|Acidimicrobiia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
GDHHQS2_k127_1425134_0	665571.STHERM_c15920	1.841e-221	708.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
GDHHQS2_k127_145108_0	369723.Strop_3041	1.271e-54	214.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4DBR2@85008|Micromonosporales	201174|Actinobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
GDHHQS2_k127_145108_1	710696.Intca_3624	2.153e-25	120.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4FJ1R@85021|Intrasporangiaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
GDHHQS2_k127_1455914_2	1304880.JAGB01000002_gene1738	1.029e-60	215.0	COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
GDHHQS2_k127_1455914_0	754252.PFREUD_15330	3.045e-141	464.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4DPIM@85009|Propionibacteriales	201174|Actinobacteria	J	ribosomal protein	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
GDHHQS2_k127_1455914_4	643562.Daes_2914	1.282e-11	75.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,42S07@68525|delta/epsilon subdivisions,2WNR0@28221|Deltaproteobacteria,2M87M@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	TIGRFAM Flp pilus assembly protein CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ChapFlgA,RcpC,SAF
GDHHQS2_k127_1455914_3	1229780.BN381_80410	7.423e-58	216.0	COG4963@1|root,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,3UXHE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	NUBPL iron-transfer P-loop NTPase	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
GDHHQS2_k127_1455914_1	710696.Intca_0504	5.745e-87	295.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4FE8N@85021|Intrasporangiaceae	201174|Actinobacteria	U	pilus assembly protein ATPase CpaF	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
GDHHQS2_k127_14788_0	309801.trd_1316	3.371e-50	196.0	COG0531@1|root,COG0531@2|Bacteria,2G76Z@200795|Chloroflexi	200795|Chloroflexi	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
GDHHQS2_k127_1493296_2	383372.Rcas_3909	1.14e-30	126.0	COG2423@1|root,COG2423@2|Bacteria,2G6BQ@200795|Chloroflexi,375XV@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ornithine cyclodeaminase mu-crystallin	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
GDHHQS2_k127_1493296_3	1122927.KB895419_gene2424	4.191e-15	76.0	COG5552@1|root,COG5552@2|Bacteria,1VCIJ@1239|Firmicutes,4HKXG@91061|Bacilli,26Z0F@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
GDHHQS2_k127_1493296_1	633147.Olsu_0691	1.366e-38	159.0	COG0477@1|root,COG2814@2|Bacteria,2HUI3@201174|Actinobacteria,4CUSE@84998|Coriobacteriia	84998|Coriobacteriia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_1493296_0	1167006.UWK_00703	1.849e-109	379.0	COG0038@1|root,COG0517@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,COG0569@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
GDHHQS2_k127_1495928_0	316274.Haur_1559	1.028e-104	350.0	COG3173@1|root,COG3173@2|Bacteria,2G5RM@200795|Chloroflexi	200795|Chloroflexi	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
GDHHQS2_k127_1495928_1	1254432.SCE1572_10355	3.399e-36	147.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
GDHHQS2_k127_1497391_3	930171.Asphe3_27670	1.56e-38	156.0	COG4655@1|root,COG4655@2|Bacteria,2IGK1@201174|Actinobacteria	201174|Actinobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
GDHHQS2_k127_1497391_2	1380393.JHVP01000003_gene1144	1.176e-41	164.0	COG3745@1|root,COG3745@2|Bacteria,2INHS@201174|Actinobacteria	201174|Actinobacteria	U	Pilus assembly protein	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
GDHHQS2_k127_1497391_1	1380393.JHVP01000003_gene1143	6.701e-60	226.0	COG4963@1|root,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,4EVMD@85013|Frankiales	201174|Actinobacteria	D	Evidence 2b Function of strongly homologous gene	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
GDHHQS2_k127_1497391_0	1380393.JHVP01000003_gene1142	2.179e-83	289.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4ERPD@85013|Frankiales	201174|Actinobacteria	U	PFAM Type II secretion system protein E	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
GDHHQS2_k127_1500207_0	28072.Nos7524_1819	2.751e-39	167.0	COG1404@1|root,COG1572@1|root,COG2374@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG4932@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,1GIN1@1117|Cyanobacteria,1HNE9@1161|Nostocales	1117|Cyanobacteria	MOQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,PPC,Peptidase_S8,SdrD_B
GDHHQS2_k127_1500207_1	324602.Caur_1399	5.626e-14	76.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia	32061|Chloroflexia	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12,TPR_2
GDHHQS2_k127_1500571_3	1150626.PHAMO_210177	8.985e-18	83.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JP9C@204441|Rhodospirillales	204441|Rhodospirillales	I	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
GDHHQS2_k127_1500571_2	1121272.KB903252_gene968	6.625e-40	150.0	COG1158@1|root,COG1158@2|Bacteria,2IKUK@201174|Actinobacteria,4DF83@85008|Micromonosporales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1500571_0	1403819.BATR01000103_gene3476	3.125e-136	448.0	COG2152@1|root,COG2152@2|Bacteria,46S8T@74201|Verrucomicrobia,2IUQX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
GDHHQS2_k127_1500571_1	1120949.KB903317_gene1866	4.848e-67	241.0	COG0438@1|root,COG0438@2|Bacteria,2I97T@201174|Actinobacteria,4DC0N@85008|Micromonosporales	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1505314_0	1385518.N798_16405	1.221e-105	353.0	COG0664@1|root,COG0664@2|Bacteria,2ID3H@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
GDHHQS2_k127_1505314_1	1292020.H483_0102800	2.724e-30	121.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 1 family	bglB	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
GDHHQS2_k127_1517151_0	1229780.BN381_250103	6.96e-106	353.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,3UWYQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Xaa-Pro aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
GDHHQS2_k127_1517151_1	103733.JNYO01000012_gene2788	1.099e-39	154.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4DYPN@85010|Pseudonocardiales	201174|Actinobacteria	S	TIGRFAM channel protein, hemolysin III family	hlyI	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
GDHHQS2_k127_1519667_1	1048339.KB913029_gene4331	9.138e-23	106.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4EUBH@85013|Frankiales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
GDHHQS2_k127_1519667_0	1123024.AUII01000014_gene4289	2.048e-143	469.0	COG1690@1|root,COG1690@2|Bacteria,2GIUP@201174|Actinobacteria,4E0T7@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
GDHHQS2_k127_1526549_1	561175.KB894093_gene4362	9.38e-35	138.0	COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4EI4K@85012|Streptosporangiales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
GDHHQS2_k127_1526549_0	570268.ANBB01000033_gene2057	3.918e-139	446.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4EGP6@85012|Streptosporangiales	201174|Actinobacteria	O	Clp amino terminal domain, pathogenicity island component	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
GDHHQS2_k127_1529453_2	1120954.ATXE01000001_gene2308	3.524e-17	81.0	2EHMB@1|root,335MH@2|Bacteria,2I701@201174|Actinobacteria,4DWFY@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1529453_0	1380394.JADL01000013_gene582	6.575e-92	308.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TUI2@28211|Alphaproteobacteria,2JSEI@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
GDHHQS2_k127_1529453_1	485913.Krac_4869	1.669e-34	134.0	COG3191@1|root,COG3191@2|Bacteria,2G83Q@200795|Chloroflexi	200795|Chloroflexi	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
GDHHQS2_k127_1534664_1	926560.KE387027_gene881	1.059e-59	213.0	COG0031@1|root,COG0031@2|Bacteria,1WJ3S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
GDHHQS2_k127_1534664_0	318424.EU78_16145	1.508e-146	485.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,23761@1762|Mycobacteriaceae	201174|Actinobacteria	I	Biotin carboxylase	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
GDHHQS2_k127_1536897_1	926569.ANT_11030	4.831e-31	124.0	COG1449@1|root,COG4945@1|root,COG1449@2|Bacteria,COG4945@2|Bacteria	2|Bacteria	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Glucodextran_C,Glyco_hydro_57
GDHHQS2_k127_1536897_0	204669.Acid345_1614	2.604e-73	253.0	COG5587@1|root,COG5587@2|Bacteria,3Y4D4@57723|Acidobacteria,2JJ1B@204432|Acidobacteriia	204432|Acidobacteriia	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
GDHHQS2_k127_1536897_2	1244869.H261_09272	2.12e-27	119.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TVDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
GDHHQS2_k127_1540047_1	1118054.CAGW01000050_gene1226	1.618e-16	90.0	COG2197@1|root,COG2197@2|Bacteria,1TSBV@1239|Firmicutes,4HC74@91061|Bacilli,26U3I@186822|Paenibacillaceae	91061|Bacilli	T	LuxR family transcriptional regulator	nreC	-	-	ko:K07696	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
GDHHQS2_k127_1540047_0	616991.JPOO01000001_gene4133	2.526e-19	94.0	COG3595@1|root,COG3595@2|Bacteria,4NNN5@976|Bacteroidetes,1I27D@117743|Flavobacteriia	976|Bacteroidetes	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
GDHHQS2_k127_1540047_3	933262.AXAM01000011_gene1778	0.0002089	49.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2MI6F@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	yfdZ	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_1540047_2	684949.ATTJ01000001_gene2488	1.513e-05	55.0	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	ko:K03668,ko:K09914	-	-	-	-	ko00000	-	-	-	DUF4377,META,YscW
GDHHQS2_k127_15561_1	649638.Trad_0120	1.701e-51	186.0	COG1012@1|root,COG1012@2|Bacteria,1WJDV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_15561_0	1313172.YM304_16810	6.867e-91	310.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
GDHHQS2_k127_1557849_1	883069.HMPREF9238_01123	4.076e-08	57.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4D45M@85005|Actinomycetales	201174|Actinobacteria	S	Peptidase, S54 family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
GDHHQS2_k127_1557849_0	1229780.BN381_430072	1.578e-274	868.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,3UWBK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
GDHHQS2_k127_1568408_0	1279038.KB907356_gene1994	2.228e-145	468.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2TUDG@28211|Alphaproteobacteria,2JQQB@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_1574214_1	1464048.JNZS01000030_gene1809	1.243e-12	70.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4D8FD@85008|Micromonosporales	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
GDHHQS2_k127_1574214_0	1122182.KB903839_gene1102	8.764e-128	424.0	COG1404@1|root,COG2133@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria,2GJFY@201174|Actinobacteria,4DASA@85008|Micromonosporales	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CarboxypepD_reg,F5_F8_type_C,GSDH,PA14,PKD
GDHHQS2_k127_1586083_1	575615.HMPREF0670_00042	9.37e-13	73.0	COG0357@1|root,COG0357@2|Bacteria,4NEJG@976|Bacteroidetes,2FMRQ@200643|Bacteroidia	976|Bacteroidetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
GDHHQS2_k127_1586083_0	1313172.YM304_42850	3.371e-97	325.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CMSR@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
GDHHQS2_k127_1594601_4	498761.HM1_2262	6.544e-33	143.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,25HJP@186801|Clostridia	186801|Clostridia	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
GDHHQS2_k127_1594601_2	351607.Acel_1539	8.187e-62	217.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4ESC9@85013|Frankiales	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
GDHHQS2_k127_1594601_0	111780.Sta7437_3943	5.066e-95	316.0	COG0528@1|root,COG0528@2|Bacteria,1G0CR@1117|Cyanobacteria,3VICS@52604|Pleurocapsales	1117|Cyanobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
GDHHQS2_k127_1594601_3	381764.Fnod_0199	8.355e-52	192.0	COG0264@1|root,COG0264@2|Bacteria,2GCGY@200918|Thermotogae	200918|Thermotogae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
GDHHQS2_k127_1594601_1	390989.JOEG01000008_gene1489	5.532e-78	270.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4D92P@85008|Micromonosporales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
GDHHQS2_k127_159709_1	670487.Ocepr_1909	3.107e-28	128.0	COG0642@1|root,COG2205@2|Bacteria	670487.Ocepr_1909|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_159709_0	1524467.IV04_23105	4.986e-66	227.0	COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,1RMIG@1236|Gammaproteobacteria,3ZZMB@613|Serratia	1236|Gammaproteobacteria	C	L-glyceraldehyde 3-phosphate reductase	yghZ	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
GDHHQS2_k127_1608482_2	1132509.C447_02557	4.554e-14	78.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23SW0@183963|Halobacteria	183963|Halobacteria	M	COG0451 Nucleoside-diphosphate-sugar epimerases	galE2	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
GDHHQS2_k127_1608482_0	67352.JODS01000028_gene2344	1.958e-53	202.0	COG0438@1|root,COG0438@2|Bacteria,2GNR8@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	ko:K19424	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_1608482_1	411154.GFO_2001	3.583e-35	145.0	COG1247@1|root,COG1247@2|Bacteria,4NM05@976|Bacteroidetes,1I10N@117743|Flavobacteriia	976|Bacteroidetes	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
GDHHQS2_k127_1622837_0	1150864.MILUP08_41440	3.556e-55	197.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4DCXA@85008|Micromonosporales	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
GDHHQS2_k127_1622837_3	1313172.YM304_18600	3.472e-18	91.0	COG0711@1|root,COG0711@2|Bacteria,2HG9T@201174|Actinobacteria,4CN89@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1622837_2	1035308.AQYY01000001_gene3137	1.36e-20	102.0	COG1399@1|root,COG1399@2|Bacteria	2|Bacteria	K	metal-binding, possibly nucleic acid-binding protein	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
GDHHQS2_k127_1622837_4	316067.Geob_2610	1.048e-15	81.0	COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42XHF@68525|delta/epsilon subdivisions,2WSX6@28221|Deltaproteobacteria,43SSW@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	structural constituent of ribosome	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
GDHHQS2_k127_1622837_1	670487.Ocepr_1898	3.727e-28	118.0	COG0416@1|root,COG0416@2|Bacteria,1WJ6C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
GDHHQS2_k127_1629550_0	469383.Cwoe_2658	2.636e-140	451.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CP7J@84995|Rubrobacteria	84995|Rubrobacteria	D	Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
GDHHQS2_k127_1629550_1	1452718.JBOY01000059_gene1590	2.503e-13	80.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
GDHHQS2_k127_1630787_5	1713.JOFV01000008_gene3232	1.405e-32	132.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4F0MC@85016|Cellulomonadaceae	201174|Actinobacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
GDHHQS2_k127_1630787_4	638302.HMPREF0908_0690	3.913e-34	139.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,4H5AT@909932|Negativicutes	909932|Negativicutes	FG	Histidine triad domain protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
GDHHQS2_k127_1630787_6	1229780.BN381_80274	8.757e-21	97.0	COG1396@1|root,COG1396@2|Bacteria,2I569@201174|Actinobacteria	201174|Actinobacteria	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
GDHHQS2_k127_1630787_8	1313172.YM304_21130	3.499e-12	75.0	COG1385@1|root,COG1385@2|Bacteria,2HGFD@201174|Actinobacteria,4CND1@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
GDHHQS2_k127_1630787_1	743718.Isova_1979	2.012e-88	304.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4F3YE@85017|Promicromonosporaceae	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
GDHHQS2_k127_1630787_3	1463821.JOGR01000006_gene2605	6.057e-48	184.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4EXMH@85014|Glycomycetales	201174|Actinobacteria	K	HrcA protein C terminal domain	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
GDHHQS2_k127_1630787_2	1382356.JQMP01000003_gene1577	2.678e-79	278.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi,27XYQ@189775|Thermomicrobia	189775|Thermomicrobia	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
GDHHQS2_k127_1630787_0	1121346.KB899847_gene66	4.779e-256	804.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,4HASA@91061|Bacilli,26RUU@186822|Paenibacillaceae	91061|Bacilli	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
GDHHQS2_k127_1630787_7	1229780.BN381_80262	6.7e-17	85.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,3UWXJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
GDHHQS2_k127_1633778_0	1032480.MLP_45460	2.398e-91	316.0	COG4990@1|root,COG4990@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	BtrH_N,DUF4872
GDHHQS2_k127_1633778_1	338966.Ppro_0566	5.994e-61	217.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,43TEH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_163867_1	1173263.Syn7502_00028	6.051e-125	414.0	COG0737@1|root,COG0737@2|Bacteria,1GCGH@1117|Cyanobacteria,1H1EQ@1129|Synechococcus	1117|Cyanobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K01119	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
GDHHQS2_k127_163867_0	1121904.ARBP01000009_gene4200	3.393e-300	932.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,47KS7@768503|Cytophagia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
GDHHQS2_k127_1643376_1	28444.JODQ01000007_gene5157	0.0005734	46.0	COG2720@1|root,COG2720@2|Bacteria,2GISH@201174|Actinobacteria,4EGMA@85012|Streptosporangiales	201174|Actinobacteria	V	VanW like protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
GDHHQS2_k127_1643376_0	105425.BBPL01000003_gene6946	8.754e-05	53.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,2NGJC@228398|Streptacidiphilus	201174|Actinobacteria	L	Protein of unknown function (DUF2800)	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
GDHHQS2_k127_1659808_0	485913.Krac_6992	8.13e-29	123.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
GDHHQS2_k127_1659808_1	1123023.JIAI01000006_gene269	3.763e-15	82.0	COG1403@1|root,COG1403@2|Bacteria,2INVR@201174|Actinobacteria	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
GDHHQS2_k127_1674381_0	1172188.KB911820_gene2633	5.136e-88	299.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FG4H@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
GDHHQS2_k127_1675034_0	926550.CLDAP_32030	2.043e-68	239.0	COG0673@1|root,COG0673@2|Bacteria,2G7RI@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS2_k127_1675034_3	258052.JNYV01000001_gene133	2.267e-23	111.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,2M64K@2063|Kitasatospora	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
GDHHQS2_k127_1675034_2	749927.AMED_1362	3.96e-40	157.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4E5MF@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
GDHHQS2_k127_1675034_4	479433.Caci_5300	3.807e-19	94.0	2E61P@1|root,333YK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1675034_5	589924.Ferp_0547	9.202e-05	51.0	arCOG10345@1|root,arCOG10345@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1675034_1	1124780.ANNU01000066_gene386	8.364e-49	181.0	COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes,47KCH@768503|Cytophagia	976|Bacteroidetes	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
GDHHQS2_k127_167845_0	443598.AUFA01000003_gene2147	2.673e-59	207.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TXJ5@28211|Alphaproteobacteria,3JW0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
GDHHQS2_k127_1689465_0	870187.Thini_1805	4.43e-134	434.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,1RPYU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	homoserine dehydrogenase	strU	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_3
GDHHQS2_k127_1694985_1	1177594.MIC448_2190006	3.088e-63	224.0	COG2208@1|root,COG2208@2|Bacteria,2I9FT@201174|Actinobacteria	201174|Actinobacteria	KT	Stage II sporulation protein E (SpoIIE)	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,SpoIIE
GDHHQS2_k127_1694985_0	1254432.SCE1572_02475	2.277e-74	265.0	COG4552@1|root,COG4552@2|Bacteria,1NBTH@1224|Proteobacteria,42W5G@68525|delta/epsilon subdivisions,2WXK2@28221|Deltaproteobacteria,2YW0Z@29|Myxococcales	28221|Deltaproteobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
GDHHQS2_k127_1700000_1	404589.Anae109_1200	2.088e-35	141.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,42QU8@68525|delta/epsilon subdivisions,2X5Q5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM channel protein, hemolysin III family	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
GDHHQS2_k127_1700000_0	1157637.KB892097_gene1189	7.363e-133	428.0	COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria	201174|Actinobacteria	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
GDHHQS2_k127_1702256_1	1280673.AUJJ01000029_gene923	6.71e-07	59.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,4BWA9@830|Butyrivibrio	186801|Clostridia	M	rod shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
GDHHQS2_k127_1702256_0	351607.Acel_0748	3.078e-101	333.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4ES3S@85013|Frankiales	201174|Actinobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
GDHHQS2_k127_1729392_1	28072.Nos7524_0431	1.647e-11	65.0	COG4091@1|root,COG4091@2|Bacteria,1G1RV@1117|Cyanobacteria,1HIT5@1161|Nostocales	1117|Cyanobacteria	E	PFAM SAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
GDHHQS2_k127_1729392_0	926569.ANT_06580	2.3e-53	200.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
GDHHQS2_k127_1736426_0	857087.Metme_2224	4.712e-221	704.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1XDIT@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
GDHHQS2_k127_1743502_4	1157640.AQWO01000002_gene4267	1.818e-35	140.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria	201174|Actinobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
GDHHQS2_k127_1743502_5	1121877.JQKF01000023_gene2253	3.105e-28	117.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4CN68@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1743502_2	1313172.YM304_21600	6.407e-92	317.0	COG0477@1|root,COG2814@2|Bacteria,2GIR8@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
GDHHQS2_k127_1743502_3	222534.KB893670_gene3784	5.618e-39	159.0	COG2845@1|root,COG2845@2|Bacteria,2GU62@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF459)	-	-	-	ko:K09795	-	-	-	-	ko00000	-	-	-	DUF459
GDHHQS2_k127_1743502_0	326424.FRAAL6221	9.066e-154	499.0	COG1696@1|root,COG1696@2|Bacteria,2GM6Z@201174|Actinobacteria,4EUU2@85013|Frankiales	201174|Actinobacteria	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	ko:K03739,ko:K19294	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00725	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	MBOAT
GDHHQS2_k127_1743502_1	1123320.KB889592_gene4281	6.669e-110	375.0	COG1306@1|root,COG1306@2|Bacteria,2GNVR@201174|Actinobacteria	201174|Actinobacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
GDHHQS2_k127_1743607_0	1340493.JNIF01000003_gene3500	1.442e-85	292.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	dgoD	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS2_k127_1743607_1	570952.ATVH01000018_gene3347	1.841e-47	174.0	COG0717@1|root,COG0717@2|Bacteria,1MVDH@1224|Proteobacteria,2TR5U@28211|Alphaproteobacteria,2JQI3@204441|Rhodospirillales	204441|Rhodospirillales	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
GDHHQS2_k127_1749238_0	67315.JOBD01000015_gene6499	7.848e-191	608.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
GDHHQS2_k127_1760124_0	1121106.JQKB01000015_gene5754	1.952e-92	312.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,2JR5J@204441|Rhodospirillales	204441|Rhodospirillales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
GDHHQS2_k127_1760124_1	1121272.KB903291_gene3597	0.0006157	42.0	COG4430@1|root,COG4430@2|Bacteria,2INBH@201174|Actinobacteria,4DJAE@85008|Micromonosporales	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
GDHHQS2_k127_1761239_0	345341.KUTG_05321	6.108e-79	271.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4DZAX@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
GDHHQS2_k127_1761239_1	1122611.KB903952_gene5823	1.227e-32	134.0	COG0491@1|root,COG0491@2|Bacteria,2GMHY@201174|Actinobacteria,4EJGQ@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	blaB3	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS2_k127_1764530_2	420662.Mpe_A3456	2.797e-16	79.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,1KJ4F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
GDHHQS2_k127_1764530_1	58123.JOFJ01000016_gene3999	8.43e-57	201.0	COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4EJ4N@85012|Streptosporangiales	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
GDHHQS2_k127_1764530_0	1121422.AUMW01000043_gene1190	1.233e-84	287.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,260G7@186807|Peptococcaceae	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
GDHHQS2_k127_176813_1	1122138.AQUZ01000023_gene7855	1.203e-16	82.0	COG0410@1|root,COG0410@2|Bacteria,2I8P0@201174|Actinobacteria,4DTC5@85009|Propionibacteriales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS2_k127_176813_0	1432050.IE4771_CH02349	8.238e-100	342.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,4B9HU@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	MA20_29500	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
GDHHQS2_k127_1776615_0	106370.Francci3_1314	9.053e-150	481.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4ERSS@85013|Frankiales	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
GDHHQS2_k127_1776663_1	1313172.YM304_22570	1.107e-90	310.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CMPY@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
GDHHQS2_k127_1776663_2	180281.CPCC7001_398	3.53e-29	131.0	COG1388@1|root,COG1388@2|Bacteria,1GM7W@1117|Cyanobacteria,22SWZ@167375|Cyanobium	1117|Cyanobacteria	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
GDHHQS2_k127_1776663_3	1313172.YM304_22540	3.688e-25	119.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	lytH	-	-	ko:K06401,ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	DUF3289,Peptidase_M23,SH3_3
GDHHQS2_k127_1776663_0	1254432.SCE1572_10355	1.025e-132	434.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
GDHHQS2_k127_17947_1	1210046.B277_02681	1.273e-07	59.0	COG3339@1|root,COG3339@2|Bacteria,2IR8D@201174|Actinobacteria,4FJD6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_17947_0	1255043.TVNIR_1705	1.286e-141	461.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RQS1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
GDHHQS2_k127_17947_2	1114856.C496_07808	2.665e-06	55.0	arCOG11504@1|root,arCOG11504@2157|Archaea,2XX31@28890|Euryarchaeota,23VW4@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1797495_0	502025.Hoch_1681	3.968e-71	253.0	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,42NGH@68525|delta/epsilon subdivisions,2WKS6@28221|Deltaproteobacteria,2YV7C@29|Myxococcales	28221|Deltaproteobacteria	M	RmlD substrate binding domain	-	-	1.1.1.394,1.1.1.412	ko:K21271,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD
GDHHQS2_k127_1810103_1	215803.DB30_3105	7.964e-83	287.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,2YUHP@29|Myxococcales	28221|Deltaproteobacteria	E	succinyl-diaminopimelate desuccinylase	dapE2	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
GDHHQS2_k127_1810103_0	1122182.KB903838_gene4198	2.087e-94	321.0	COG1030@1|root,COG1030@2|Bacteria	2|Bacteria	-	-	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
GDHHQS2_k127_1816957_2	590998.Celf_2159	4.718e-49	195.0	COG0454@1|root,COG0456@2|Bacteria,2I0BQ@201174|Actinobacteria,4F17M@85016|Cellulomonadaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_1816957_1	1229780.BN381_10108	4.928e-66	234.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,3UWT0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
GDHHQS2_k127_1816957_0	1192034.CAP_1099	3.41e-77	269.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,2YYMB@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.17,4.3.1.19	ko:K17989	ko00260,ko00270,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00590,R00996	RC00331,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
GDHHQS2_k127_1821253_0	926569.ANT_29290	4.035e-42	177.0	COG0438@1|root,COG2227@1|root,COG0438@2|Bacteria,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_56,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_31
GDHHQS2_k127_1821253_1	944564.HMPREF9200_0531	2.27e-41	174.0	COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,4H2WP@909932|Negativicutes	909932|Negativicutes	S	Polysaccharide pyruvyl transferase, CsaB	csaB	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
GDHHQS2_k127_1822049_0	381666.H16_A1706	7.222e-79	276.0	COG1404@1|root,COG1404@2|Bacteria,1REVZ@1224|Proteobacteria,2WDV2@28216|Betaproteobacteria,1KB1U@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
GDHHQS2_k127_182293_1	501479.ACNW01000029_gene1364	7.911e-39	149.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2U0AZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA1	-	1.1.1.310	ko:K16843	ko00270,map00270	-	R05693	RC00031	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GDHHQS2_k127_182293_0	1123242.JH636435_gene778	8.033e-89	299.0	COG3836@1|root,COG3836@2|Bacteria,2IZ23@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
GDHHQS2_k127_1830088_1	1416752.AYME01000004_gene2135	2.326e-06	51.0	COG1309@1|root,COG1309@2|Bacteria,2GJZJ@201174|Actinobacteria,4FNF5@85023|Microbacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
GDHHQS2_k127_1830088_2	1158050.KB895453_gene986	6.608e-05	51.0	2EIMI@1|root,33CCT@2|Bacteria,2GSNP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1830088_0	312284.A20C1_05587	1.959e-12	79.0	2CVPW@1|root,32SXZ@2|Bacteria,2ITC5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1844935_1	1122603.ATVI01000009_gene2716	2.695e-73	250.0	COG0737@1|root,COG2931@1|root,COG0737@2|Bacteria,COG2931@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1X88H@135614|Xanthomonadales	135614|Xanthomonadales	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
GDHHQS2_k127_1844935_0	311402.Avi_5349	4.146e-162	524.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,4B73U@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	dppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363	-	ko:K02035,ko:K12368	ko02010,ko02024,ko02030,map02010,map02024,map02030	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS2_k127_1850888_0	1449044.JMLE01000035_gene456	9.881e-127	416.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1851270_1	1288963.ADIS_4816	1.089e-05	57.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	LysM,PD40
GDHHQS2_k127_1851270_2	1347086.CCBA010000012_gene2030	1.629e-05	48.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1851270_0	754035.Mesau_00512	1.655e-32	126.0	COG0604@1|root,COG0604@2|Bacteria,1MXRA@1224|Proteobacteria,2U144@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	'Pfam Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
GDHHQS2_k127_1852016_2	1283299.AUKG01000001_gene1898	6.317e-38	146.0	COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,4CQ97@84995|Rubrobacteria	84995|Rubrobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
GDHHQS2_k127_1852016_0	1121272.KB903290_gene4517	2.384e-66	237.0	COG3694@1|root,COG3694@2|Bacteria,2GT76@201174|Actinobacteria,4DJ51@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_6
GDHHQS2_k127_1852016_1	35754.JNYJ01000023_gene8285	5.1e-49	180.0	COG4587@1|root,COG4587@2|Bacteria,2I12J@201174|Actinobacteria,4DJ7Y@85008|Micromonosporales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_6
GDHHQS2_k127_1864398_1	1502851.FG93_01105	7.973e-34	131.0	COG2346@1|root,COG2346@2|Bacteria,1Q38S@1224|Proteobacteria,2UJT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
GDHHQS2_k127_1864398_0	1205753.A989_05557	1.395e-39	158.0	COG2200@1|root,COG2203@1|root,COG2200@2|Bacteria,COG2203@2|Bacteria,1MVJY@1224|Proteobacteria,1RRCA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2
GDHHQS2_k127_1877090_0	1713.JOFV01000001_gene1928	1.124e-66	239.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4F18R@85016|Cellulomonadaceae	201174|Actinobacteria	S	Uncharacterised protein family UPF0052	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
GDHHQS2_k127_1877090_1	1229780.BN381_10186	1.351e-30	124.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,3UXCJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	F420-0:Gamma-glutamyl ligase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
GDHHQS2_k127_1884743_1	653045.Strvi_2999	3.471e-09	62.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
GDHHQS2_k127_1884743_0	1453501.JELR01000005_gene1785	8.186e-166	537.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,464PF@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
GDHHQS2_k127_1886724_1	509190.Cseg_0271	2.105e-21	101.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,2UJHW@28211|Alphaproteobacteria,2KJ5I@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
GDHHQS2_k127_1886724_0	1479235.KK366039_gene630	1.16e-25	118.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XITW@135619|Oceanospirillales	135619|Oceanospirillales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
GDHHQS2_k127_1896842_1	504728.K649_13805	1.138e-73	253.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	-	ko:K20543	-	-	-	-	ko00000,ko02000	1.B.55.3	-	-	Arylsulfotran_2,UnbV_ASPIC,VCBS
GDHHQS2_k127_1896842_0	1297570.MESS4_560033	1.03e-83	287.0	COG0006@1|root,COG0006@2|Bacteria,1N8DW@1224|Proteobacteria,2U2SF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Xaa-Pro aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_1900092_3	1123389.ATXJ01000004_gene1181	3.978e-06	51.0	COG1826@1|root,COG1826@2|Bacteria,1WKBC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
GDHHQS2_k127_1900092_2	351607.Acel_1202	8.64e-10	64.0	2BZPH@1|root,33EX8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1900092_0	1386089.N865_13170	1.733e-49	188.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4FEBU@85021|Intrasporangiaceae	201174|Actinobacteria	K	Proteasome accessory factor C	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
GDHHQS2_k127_1900092_1	1121877.JQKF01000001_gene1273	5.034e-14	81.0	COG2378@1|root,COG2378@2|Bacteria,2HGFE@201174|Actinobacteria,4CND2@84992|Acidimicrobiia	84992|Acidimicrobiia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
GDHHQS2_k127_1913348_0	953739.SVEN_2397	6.278e-113	375.0	COG0381@1|root,COG0381@2|Bacteria,2GJWS@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
GDHHQS2_k127_1918864_1	1313172.YM304_09420	4.137e-47	173.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
GDHHQS2_k127_1918864_0	266117.Rxyl_1175	3.426e-86	296.0	COG1840@1|root,COG1840@2|Bacteria,2HRRI@201174|Actinobacteria,4CTU6@84995|Rubrobacteria	84995|Rubrobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
GDHHQS2_k127_1918864_2	1033806.HTIA_1798	7.781e-37	147.0	COG1178@1|root,arCOG00163@2157|Archaea,2XUE2@28890|Euryarchaeota,23TH7@183963|Halobacteria	183963|Halobacteria	P	ABC-type Fe3 transport system, permease component	sfuB	-	3.6.3.30	ko:K02010,ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	BPD_transp_1
GDHHQS2_k127_1927137_1	1380370.JIBA01000011_gene3188	1.614e-50	185.0	COG2141@1|root,COG4639@1|root,COG2141@2|Bacteria,COG4639@2|Bacteria,2GM7W@201174|Actinobacteria,4FG4X@85021|Intrasporangiaceae	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
GDHHQS2_k127_1927137_2	765912.Thimo_1385	2.24e-47	183.0	COG5607@1|root,COG5607@2|Bacteria,1RH6R@1224|Proteobacteria,1S7KA@1236|Gammaproteobacteria,1X0XZ@135613|Chromatiales	135613|Chromatiales	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
GDHHQS2_k127_1927137_3	526226.Gbro_3585	6.439e-46	170.0	COG4119@1|root,COG4119@2|Bacteria,2IM6D@201174|Actinobacteria,4GE40@85026|Gordoniaceae	201174|Actinobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
GDHHQS2_k127_1927137_4	1231392.OCGS_1209	1.019e-24	112.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	MA20_28525	-	2.3.1.178,2.3.1.183	ko:K03823,ko:K06718	ko00260,ko00440,ko01100,ko01120,ko01130,map00260,map00440,map01100,map01120,map01130	M00033	R06978,R08871,R08938	RC00004,RC00064,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
GDHHQS2_k127_1927137_5	326298.Suden_0122	1.029e-14	85.0	2BUAB@1|root,32PJW@2|Bacteria,1Q49J@1224|Proteobacteria,42YP0@68525|delta/epsilon subdivisions,2YR52@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1927137_0	1229780.BN381_640016	3.585e-159	519.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	bglIM	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
GDHHQS2_k127_1939471_0	1298863.AUEP01000008_gene1246	4.473e-259	807.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4DTJJ@85009|Propionibacteriales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
GDHHQS2_k127_1939471_1	1298863.AUEP01000008_gene1247	5.323e-143	464.0	COG0404@1|root,COG0404@2|Bacteria,2I8C4@201174|Actinobacteria,4DTFF@85009|Propionibacteriales	201174|Actinobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1989,GCV_T,GCV_T_C
GDHHQS2_k127_195258_2	306281.AJLK01000153_gene2143	8.284e-49	183.0	COG4421@1|root,COG4421@2|Bacteria,1GD59@1117|Cyanobacteria,1JMQI@1189|Stigonemataceae	2|Bacteria	G	Protein of unknown function (DUF563)	-	-	-	-	-	-	-	-	-	-	-	-	DUF563
GDHHQS2_k127_195258_0	1157943.KB892705_gene477	8.414e-153	494.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
GDHHQS2_k127_195258_1	864702.OsccyDRAFT_4171	5.157e-110	360.0	COG1208@1|root,COG1208@2|Bacteria,1G4AN@1117|Cyanobacteria,1H8TU@1150|Oscillatoriales	1117|Cyanobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
GDHHQS2_k127_1956816_0	1394178.AWOO02000032_gene4890	3.151e-40	154.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4EH2D@85012|Streptosporangiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
GDHHQS2_k127_1958828_0	264732.Moth_2043	4.548e-104	350.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,42FB3@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
GDHHQS2_k127_1958828_1	644966.Tmar_2349	4.688e-77	263.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WCYT@538999|Clostridiales incertae sedis	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
GDHHQS2_k127_1963873_1	338963.Pcar_1756	3.084e-34	147.0	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria,42RRN@68525|delta/epsilon subdivisions,2WNAY@28221|Deltaproteobacteria,43SI2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1963873_0	479434.Sthe_0521	5.616e-61	222.0	COG2064@1|root,COG2064@2|Bacteria,2G6CF@200795|Chloroflexi,27XSY@189775|Thermomicrobia	189775|Thermomicrobia	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
GDHHQS2_k127_1963873_2	264198.Reut_A2648	6.61e-10	61.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,1K2UP@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Type II secretion system	tadB1	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
GDHHQS2_k127_1970957_0	211114.JOEF01000002_gene4471	2.491e-174	559.0	COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria,4DXPV@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
GDHHQS2_k127_1970957_1	1313172.YM304_21240	1.287e-20	103.0	2DQW0@1|root,3390A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_1978768_0	1123234.AUKI01000020_gene812	3.765e-77	273.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	ynjE	GO:0003674,GO:0003824,GO:0016740,GO:0016782,GO:0016783	2.8.1.11,5.2.1.8	ko:K01802,ko:K21028	ko04122,map04122	-	R07461	-	ko00000,ko00001,ko01000	-	-	-	FKBP_C,Rhodanese
GDHHQS2_k127_1978768_1	1229780.BN381_70076	1.87e-20	97.0	COG1404@1|root,COG1404@2|Bacteria,2H8Y3@201174|Actinobacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	B_lectin,Big_3_2,Flg_new,PKD,RCC1,RCC1_2,SLH
GDHHQS2_k127_1979394_1	1123319.AUBE01000027_gene4798	1.639e-08	62.0	COG0119@1|root,COG1853@1|root,COG0119@2|Bacteria,COG1853@2|Bacteria,2GPJS@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,HMGL-like
GDHHQS2_k127_1979394_0	1313172.YM304_00520	1.247e-97	325.0	COG1960@1|root,COG1960@2|Bacteria,2H7DI@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_1982082_1	68170.KL590485_gene8320	1.813e-57	203.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4E11C@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS2_k127_1982082_0	356851.JOAN01000001_gene3287	2.138e-62	226.0	COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4D9NV@85008|Micromonosporales	201174|Actinobacteria	M	exporter of polyketide	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
GDHHQS2_k127_1988655_0	671143.DAMO_1503	1.387e-157	508.0	COG0436@1|root,COG0436@2|Bacteria,2NQG2@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class I and II	yfdZ	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405	Aminotran_1_2
GDHHQS2_k127_1988655_1	192952.MM_0628	0.0001067	52.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
GDHHQS2_k127_1994147_2	62928.azo2647	6.675e-20	100.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,2KUU6@206389|Rhodocyclales	206389|Rhodocyclales	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
GDHHQS2_k127_1994147_1	1205910.B005_1046	2.005e-45	181.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4EFQT@85012|Streptosporangiales	201174|Actinobacteria	K	LytR cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
GDHHQS2_k127_1994147_0	1229780.BN381_10176	6.33e-123	407.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,3UW6R@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
GDHHQS2_k127_2000031_1	1231391.AMZF01000020_gene2010	1.063e-27	126.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUFT@1224|Proteobacteria	1224|Proteobacteria	E	(ABC) transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS2_k127_2000031_0	1231391.AMZF01000020_gene2009	3.266e-52	194.0	COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2VPYC@28216|Betaproteobacteria,3T2PS@506|Alcaligenaceae	28216|Betaproteobacteria	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_2018590_0	391037.Sare_1819	6.47e-209	674.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4DA2Y@85008|Micromonosporales	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
GDHHQS2_k127_2019129_2	1306990.BARG01000037_gene4335	0.0004631	45.0	COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type spermidine putrescine transport system, permease component I	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
GDHHQS2_k127_2019129_0	1168059.KB899087_gene2424	6.14e-170	542.0	COG0687@1|root,COG0687@2|Bacteria,1NKD7@1224|Proteobacteria,2TYST@28211|Alphaproteobacteria,3F0UM@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding protein	ydcS	GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
GDHHQS2_k127_2019129_1	1380391.JIAS01000012_gene4479	2.143e-127	418.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JRAV@204441|Rhodospirillales	204441|Rhodospirillales	E	TOBE domain	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
GDHHQS2_k127_2030927_0	1095767.CAHD01000138_gene2283	2.826e-23	99.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4F0QG@85016|Cellulomonadaceae	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_2030927_1	1121926.AXWO01000016_gene4132	4.778e-10	68.0	COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,4EYPG@85014|Glycomycetales	201174|Actinobacteria	S	protein encoded in hypervariable junctions of pilus gene clusters	-	-	-	-	-	-	-	-	-	-	-	-	Arc,HicB
GDHHQS2_k127_2030927_2	408672.NBCG_03246	1.847e-09	68.0	COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria,4DRPH@85009|Propionibacteriales	201174|Actinobacteria	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
GDHHQS2_k127_2043123_3	991905.SL003B_1043	7.321e-29	117.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TUQB@28211|Alphaproteobacteria,4BPY3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Amino acid amide ABC transporter, ATP-binding protein, 1, HAAT family	-	-	-	ko:K01995,ko:K11957	ko02010,ko02024,map02010,map02024	M00237,M00322	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.2,3.A.1.4.6	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS2_k127_2043123_2	1120983.KB894571_gene2471	1.633e-85	293.0	COG0410@1|root,COG0410@2|Bacteria	2|Bacteria	E	branched-chain amino acid transmembrane transporter activity	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS2_k127_2043123_1	991905.SL003B_1041	3.998e-97	325.0	COG0559@1|root,COG0559@2|Bacteria,1MXHF@1224|Proteobacteria,2U4PU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_2043123_0	1120983.KB894571_gene2473	2.69e-97	344.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,1JPAC@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_2049879_0	1382306.JNIM01000001_gene2513	3.713e-72	253.0	COG2141@1|root,COG2141@2|Bacteria,2G8PY@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_2049879_1	1449058.JQKT01000007_gene1434	6.715e-26	111.0	COG4319@1|root,COG4319@2|Bacteria,2IRHC@201174|Actinobacteria,4FQIA@85023|Microbacteriaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
GDHHQS2_k127_2054877_0	1157637.KB892107_gene3856	3.027e-124	413.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
GDHHQS2_k127_2054877_1	2002.JOEQ01000020_gene7064	2.029e-34	143.0	COG0500@1|root,COG2226@2|Bacteria,2IP4P@201174|Actinobacteria,4EKAN@85012|Streptosporangiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
GDHHQS2_k127_2054877_2	105420.BBPO01000041_gene582	1.89e-17	87.0	COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria,2NF6K@228398|Streptacidiphilus	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
GDHHQS2_k127_2059402_1	351607.Acel_0546	6.775e-40	166.0	COG2206@1|root,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,4ETB2@85013|Frankiales	201174|Actinobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
GDHHQS2_k127_2059402_2	243274.THEMA_01320	8.906e-14	80.0	2C0MY@1|root,2ZC2Z@2|Bacteria,2GD2U@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2059402_0	479432.Sros_6881	4.835e-47	179.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4EIAB@85012|Streptosporangiales	201174|Actinobacteria	E	Gamma-glutamyltranspeptidase	ywrD	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
GDHHQS2_k127_2066150_0	405948.SACE_5882	1.299e-96	332.0	COG0621@1|root,COG0621@2|Bacteria,2GKRI@201174|Actinobacteria,4DX5V@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
GDHHQS2_k127_2066150_2	512565.AMIS_80330	2.766e-34	137.0	COG1853@1|root,COG1853@2|Bacteria,2IP6R@201174|Actinobacteria,4DCXF@85008|Micromonosporales	201174|Actinobacteria	S	flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
GDHHQS2_k127_2066150_1	1449355.JQNR01000005_gene5023	1.383e-63	224.0	COG1387@1|root,COG1387@2|Bacteria,2IR14@201174|Actinobacteria	201174|Actinobacteria	E	Histidinol phosphate phosphatase, HisJ	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
GDHHQS2_k127_2066348_0	765420.OSCT_1489	5.742e-50	189.0	COG0719@1|root,COG0719@2|Bacteria,2G5TI@200795|Chloroflexi,374ZV@32061|Chloroflexia	32061|Chloroflexia	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
GDHHQS2_k127_2066348_1	1122247.C731_4142	8.736e-45	168.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,2343P@1762|Mycobacteriaceae	201174|Actinobacteria	E	glutamate synthase	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
GDHHQS2_k127_2104155_1	590998.Celf_3649	4.553e-26	109.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
GDHHQS2_k127_2104155_0	1298880.AUEV01000004_gene1998	2.669e-57	207.0	COG0500@1|root,COG1247@1|root,COG1247@2|Bacteria,COG2226@2|Bacteria,2HEKM@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_4,Methyltransf_31
GDHHQS2_k127_2106620_1	1229780.BN381_350043	5.419e-46	169.0	COG4420@1|root,COG4420@2|Bacteria,2GQ5D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
GDHHQS2_k127_2106620_2	1380356.JNIK01000005_gene1082	2.529e-45	170.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4ESPH@85013|Frankiales	201174|Actinobacteria	L	Belongs to the DNA glycosylase MPG family	alkA	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
GDHHQS2_k127_2106620_0	264732.Moth_1709	3.358e-93	314.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,42FBT@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
GDHHQS2_k127_2119097_1	1136417.AZWE01000032_gene364	3.364e-12	66.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DC7S@85008|Micromonosporales	201174|Actinobacteria	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
GDHHQS2_k127_2119097_0	1386089.N865_15080	2.09e-107	356.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4FFYW@85021|Intrasporangiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
GDHHQS2_k127_2122573_0	351607.Acel_1603	8.74e-51	185.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4ESID@85013|Frankiales	201174|Actinobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
GDHHQS2_k127_2122573_2	411490.ANACAC_00014	5.079e-19	93.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
GDHHQS2_k127_2122573_1	1121423.JONT01000001_gene2052	2.898e-39	152.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,260DT@186807|Peptococcaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
GDHHQS2_k127_212404_0	309801.trd_0153	8.109e-146	468.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_6,Pyr_redox_2
GDHHQS2_k127_212404_1	1121877.JQKF01000008_gene602	1.654e-48	174.0	COG2048@1|root,COG2048@2|Bacteria,2HGMN@201174|Actinobacteria,4CNM6@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
GDHHQS2_k127_2132870_0	525909.Afer_0947	2.707e-176	566.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CMVH@84992|Acidimicrobiia	84992|Acidimicrobiia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
GDHHQS2_k127_2144428_1	797209.ZOD2009_05582	1.485e-17	89.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2XX7K@28890|Euryarchaeota,23VK2@183963|Halobacteria	183963|Halobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
GDHHQS2_k127_2144428_0	525904.Tter_0194	2.503e-225	708.0	COG0065@1|root,COG0065@2|Bacteria,2NP2K@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
GDHHQS2_k127_2146281_2	1128421.JAGA01000003_gene3360	3.835e-75	261.0	COG0765@1|root,COG0765@2|Bacteria,2NPKZ@2323|unclassified Bacteria	2|Bacteria	E	Binding-protein-dependent transport system inner membrane component	yxeN	-	3.4.15.5	ko:K01284,ko:K02029	-	M00236	-	-	ko00000,ko00002,ko01000,ko01002,ko02000	3.A.1.3	-	-	BPD_transp_1
GDHHQS2_k127_2146281_1	765420.OSCT_1426	6.486e-91	306.0	COG1126@1|root,COG1126@2|Bacteria,2G5UB@200795|Chloroflexi,376F8@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
GDHHQS2_k127_2146281_0	1449353.JQMQ01000005_gene3238	1.05e-137	442.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,2NGBN@228398|Streptacidiphilus	201174|Actinobacteria	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
GDHHQS2_k127_214702_0	3218.PP1S135_118V6.1	3.431e-139	454.0	COG0436@1|root,KOG0257@2759|Eukaryota,37HWK@33090|Viridiplantae,3G9MN@35493|Streptophyta	35493|Streptophyta	E	Kynurenine--oxoglutarate transaminase	-	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
GDHHQS2_k127_214702_1	469371.Tbis_3322	1.639e-94	324.0	COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4E8UC@85010|Pseudonocardiales	201174|Actinobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
GDHHQS2_k127_2168457_1	1538295.JY96_21810	1.956e-28	116.0	COG3759@1|root,COG3759@2|Bacteria,1MZ4F@1224|Proteobacteria,2VUPP@28216|Betaproteobacteria,1KMDF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1304)	-	-	-	ko:K08987	-	-	-	-	ko00000	-	-	-	DUF1304
GDHHQS2_k127_2168457_0	83332.Rv3032A	8.802e-33	133.0	2C72U@1|root,32W8F@2|Bacteria,2GTSA@201174|Actinobacteria,2396T@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2168457_2	1254432.SCE1572_08285	9.652e-17	91.0	COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria,1QZ4N@1224|Proteobacteria,42QFK@68525|delta/epsilon subdivisions,2WJSD@28221|Deltaproteobacteria,2Z31R@29|Myxococcales	28221|Deltaproteobacteria	K	PBP superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,PBP_like
GDHHQS2_k127_2171481_1	526225.Gobs_2142	1.232e-96	329.0	COG3391@1|root,COG4995@1|root,COG3391@2|Bacteria,COG4995@2|Bacteria,2HF98@201174|Actinobacteria,4EWDJ@85013|Frankiales	201174|Actinobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2171481_0	1122138.AQUZ01000039_gene8018	1.631e-98	330.0	COG3386@1|root,COG3386@2|Bacteria,2HDRT@201174|Actinobacteria,4DNUM@85009|Propionibacteriales	201174|Actinobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
GDHHQS2_k127_2175443_0	1123023.JIAI01000004_gene7828	5.725e-131	428.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2GJCK@201174|Actinobacteria,4DZEM@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
GDHHQS2_k127_2175443_1	1123393.KB891326_gene54	2.296e-88	301.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VHPC@28216|Betaproteobacteria,1KRHB@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Formate dehydrogenase N, transmembrane	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_7,Form-deh_trans
GDHHQS2_k127_2175443_2	234267.Acid_0835	1.638e-31	131.0	COG2864@1|root,COG2864@2|Bacteria,3Y884@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome b/b6/petB	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
GDHHQS2_k127_217599_1	93220.LV28_04990	7.615e-44	169.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2VIJM@28216|Betaproteobacteria,1KGR8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	N-carbamoyl-D-amino acid hydrolase	-	-	3.5.1.77	ko:K01459	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
GDHHQS2_k127_217599_0	1232436.CAPF01000006_gene1819	3.822e-46	182.0	COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria,4CUVV@84998|Coriobacteriia	84998|Coriobacteriia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
GDHHQS2_k127_2194528_1	35754.JNYJ01000043_gene4419	8.674e-37	144.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4D9RI@85008|Micromonosporales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
GDHHQS2_k127_2194528_2	1313172.YM304_37890	5.092e-13	75.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
GDHHQS2_k127_2194528_0	58123.JOFJ01000020_gene3726	4.269e-39	151.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4EFJR@85012|Streptosporangiales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_2213900_2	344747.PM8797T_22153	1.445e-56	205.0	COG0128@1|root,COG0128@2|Bacteria,2IXRF@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
GDHHQS2_k127_2213900_3	1150599.MPHLEI_27142	1.294e-52	197.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,235IQ@1762|Mycobacteriaceae	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
GDHHQS2_k127_2213900_0	1313172.YM304_25520	1.069e-104	352.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CMP7@84992|Acidimicrobiia	84992|Acidimicrobiia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
GDHHQS2_k127_2213900_1	1120971.AUCA01000042_gene1228	8.553e-76	263.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae	91061|Bacilli	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
GDHHQS2_k127_2215813_0	649638.Trad_1259	2.895e-180	574.0	COG0045@1|root,COG0045@2|Bacteria,1WIT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
GDHHQS2_k127_2215813_1	1123023.JIAI01000014_gene3642	7.837e-53	188.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4E4D0@85010|Pseudonocardiales	201174|Actinobacteria	I	B12 binding domain	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
GDHHQS2_k127_2216302_1	1120965.AUBV01000016_gene94	6.64e-23	102.0	2BWYK@1|root,32R5D@2|Bacteria,4NS4D@976|Bacteroidetes	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4,PAS_8
GDHHQS2_k127_2216302_0	1394178.AWOO02000035_gene8962	1.331e-93	325.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,Trans_reg_C
GDHHQS2_k127_2252895_0	525904.Tter_2412	8.162e-29	131.0	COG2856@1|root,COG2856@2|Bacteria,2NQY0@2323|unclassified Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2278756_0	1120933.ATUY01000004_gene1111	2.422e-58	210.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4D3NP@85005|Actinomycetales	201174|Actinobacteria	F	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
GDHHQS2_k127_2283126_0	656519.Halsa_0381	7.272e-73	250.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,3WAIB@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
GDHHQS2_k127_2283126_2	633147.Olsu_0031	1.793e-30	128.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4CV02@84998|Coriobacteriia	84998|Coriobacteriia	L	Hydrolase, NUDIX family	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
GDHHQS2_k127_2283126_1	562970.Btus_1322	1.284e-39	152.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,4HABX@91061|Bacilli,277YI@186823|Alicyclobacillaceae	91061|Bacilli	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
GDHHQS2_k127_2298438_0	1229780.BN381_300027	2.367e-183	593.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
GDHHQS2_k127_2300253_2	1206733.BAGC01000040_gene1476	3.655e-34	141.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4G1M0@85025|Nocardiaceae	201174|Actinobacteria	CP	Proton-conducting membrane transporter	hycQ	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
GDHHQS2_k127_2300253_1	1304865.JAGF01000001_gene3525	1.465e-49	189.0	COG4237@1|root,COG4237@2|Bacteria,2HQ3P@201174|Actinobacteria	201174|Actinobacteria	C	Hydrogenase 4 membrane	hycP	GO:0008150,GO:0040007	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
GDHHQS2_k127_2300253_0	1449346.JQMO01000002_gene643	1.078e-78	270.0	COG0650@1|root,COG0650@2|Bacteria,2GJFM@201174|Actinobacteria	201174|Actinobacteria	C	Formate hydrogenlyase	hycD	-	-	ko:K12138	-	-	-	-	ko00000,ko01000	-	-	-	NADHdh
GDHHQS2_k127_2323115_1	366649.XFF4834R_chr12820	1.192e-16	93.0	COG0739@1|root,COG0739@2|Bacteria,1RK7E@1224|Proteobacteria,1RYS2@1236|Gammaproteobacteria,1X698@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
GDHHQS2_k127_2323115_2	714961.BFZC1_23793	1.583e-15	89.0	COG0791@1|root,COG0791@2|Bacteria,1UMV8@1239|Firmicutes,4HK5E@91061|Bacilli,3J08Z@400634|Lysinibacillus	91061|Bacilli	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
GDHHQS2_k127_2323115_0	1313172.YM304_04580	2.162e-35	149.0	COG1595@1|root,COG1595@2|Bacteria,2IHVZ@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_2325092_1	574087.Acear_0559	3.071e-78	286.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,3WA9D@53433|Halanaerobiales	186801|Clostridia	M	Penicillin-binding protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
GDHHQS2_k127_2325092_2	525909.Afer_0956	7.555e-78	274.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CN2U@84992|Acidimicrobiia	84992|Acidimicrobiia	D	Cell cycle protein	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
GDHHQS2_k127_2325092_3	1340493.JNIF01000004_gene501	5.31e-63	222.0	COG1435@1|root,COG1435@2|Bacteria,3Y4XG@57723|Acidobacteria	57723|Acidobacteria	F	PFAM Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
GDHHQS2_k127_2325092_0	1122138.AQUZ01000019_gene8195	5.541e-88	301.0	COG4188@1|root,COG4188@2|Bacteria,2GJVV@201174|Actinobacteria,4DVFU@85009|Propionibacteriales	201174|Actinobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
GDHHQS2_k127_232559_5	1117108.PAALTS15_15491	2.64e-08	65.0	2BVJM@1|root,32QXJ@2|Bacteria,1V8X3@1239|Firmicutes,4HIQ1@91061|Bacilli,26YIN@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_232559_3	1380390.JIAT01000009_gene539	9.983e-56	206.0	COG0583@1|root,COG0583@2|Bacteria,2HFRR@201174|Actinobacteria,4CRN8@84995|Rubrobacteria	84995|Rubrobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
GDHHQS2_k127_232559_2	1500257.JQNM01000019_gene2757	3.946e-89	307.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652,Polyketide_cyc2
GDHHQS2_k127_232559_1	103733.JNYO01000018_gene3276	1.003e-109	361.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4DYS9@85010|Pseudonocardiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
GDHHQS2_k127_232559_0	1179773.BN6_17560	1.769e-134	436.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DXJD@85010|Pseudonocardiales	201174|Actinobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990,ko:K18232	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC_tran,DUF4162
GDHHQS2_k127_232559_4	324602.Caur_2581	9.356e-17	86.0	COG4454@1|root,COG4454@2|Bacteria,2G9EX@200795|Chloroflexi	200795|Chloroflexi	P	Blue (Type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2326919_2	1123321.KB905818_gene4820	8.429e-12	70.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
GDHHQS2_k127_2326919_1	1341646.CBMO010000050_gene3915	6.204e-55	203.0	COG3876@1|root,COG3876@2|Bacteria,2GJ19@201174|Actinobacteria,236UN@1762|Mycobacteriaceae	201174|Actinobacteria	S	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
GDHHQS2_k127_2326919_0	469383.Cwoe_2884	8.71e-113	389.0	COG1948@1|root,COG4880@2|Bacteria,2I8JU@201174|Actinobacteria	201174|Actinobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
GDHHQS2_k127_2332318_0	525904.Tter_0195	5.956e-68	238.0	COG0066@1|root,COG0066@2|Bacteria,2NRA0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2987c	Aconitase_C
GDHHQS2_k127_2332318_1	1254432.SCE1572_42070	9.74e-23	111.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,439XM@68525|delta/epsilon subdivisions,2X1UY@28221|Deltaproteobacteria,2Z0MH@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
GDHHQS2_k127_2332318_2	1170318.PALO_04865	1.179e-13	71.0	COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4DQB5@85009|Propionibacteriales	201174|Actinobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ2	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
GDHHQS2_k127_2336558_1	911239.CF149_17600	2.68e-46	173.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
GDHHQS2_k127_2336558_0	1089544.KB912942_gene2104	1.542e-70	250.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4E14W@85010|Pseudonocardiales	201174|Actinobacteria	S	overlaps another CDS with the same product name	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
GDHHQS2_k127_2347611_0	1313172.YM304_32200	5.226e-125	417.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4CNZP@84992|Acidimicrobiia	84992|Acidimicrobiia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GDHHQS2_k127_2372642_2	1123023.JIAI01000003_gene2646	1.438e-06	50.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS2_k127_2372642_1	1123023.JIAI01000003_gene2646	4.018e-23	102.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS2_k127_2372642_0	1502851.FG93_02175	8.588e-35	139.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2U22N@28211|Alphaproteobacteria,3K64N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn _helix lactose operon repressor	cytR	-	-	ko:K02529,ko:K05499	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
GDHHQS2_k127_2374780_1	1380347.JNII01000009_gene2009	1.756e-25	110.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_2374780_0	285535.JOEY01000073_gene9814	1.258e-44	169.0	COG0329@1|root,COG0329@2|Bacteria,2I92Q@201174|Actinobacteria	201174|Actinobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
GDHHQS2_k127_238325_0	1385518.N798_16405	2.211e-77	270.0	COG0664@1|root,COG0664@2|Bacteria,2ID3H@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
GDHHQS2_k127_2386707_0	1276920.ADIAG_02275	6.087e-26	113.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,1W9H0@1268|Micrococcaceae	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
GDHHQS2_k127_2391167_2	1122138.AQUZ01000021_gene8512	1.255e-32	131.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4DV29@85009|Propionibacteriales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_2391167_1	1123023.JIAI01000007_gene1945	1.665e-43	162.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5FV@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2391167_0	926550.CLDAP_07090	3.821e-53	192.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
GDHHQS2_k127_2416009_4	1123023.JIAI01000007_gene1886	3.396e-18	85.0	COG1960@1|root,COG1960@2|Bacteria,2HEKC@201174|Actinobacteria,4DZQY@85010|Pseudonocardiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_2416009_1	365528.KB891230_gene1937	1.16e-46	178.0	COG1376@1|root,COG1376@2|Bacteria,2INDP@201174|Actinobacteria	201174|Actinobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
GDHHQS2_k127_2416009_0	1125863.JAFN01000001_gene401	5.287e-104	348.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,42P72@68525|delta/epsilon subdivisions,2WKRS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	-	1.1.1.26	ko:K00015,ko:K15893	ko00260,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map01100,map01110,map01120,map01130,map01200	M00532	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GDHHQS2_k127_2416009_2	1463901.JOIY01000023_gene5131	5.979e-29	123.0	COG1285@1|root,COG1285@2|Bacteria,2GJF0@201174|Actinobacteria	201174|Actinobacteria	S	PFAM MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
GDHHQS2_k127_2416009_3	293826.Amet_2776	1.527e-27	117.0	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,36J5Q@31979|Clostridiaceae	186801|Clostridia	H	thiamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
GDHHQS2_k127_2438289_0	196162.Noca_4966	1.797e-125	417.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994,ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
GDHHQS2_k127_2438289_1	252305.OB2597_14376	7.625e-07	51.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TU6H@28211|Alphaproteobacteria,2PF3R@252301|Oceanicola	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
GDHHQS2_k127_2444598_1	926550.CLDAP_37840	2.393e-102	340.0	COG0541@1|root,COG0541@2|Bacteria,2G627@200795|Chloroflexi	200795|Chloroflexi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
GDHHQS2_k127_2444598_2	449447.MAE_11070	1.785e-11	68.0	COG2350@1|root,COG2350@2|Bacteria,1G7RR@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
GDHHQS2_k127_2444598_0	105425.BBPL01000051_gene5779	4.412e-169	548.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,2NGFU@228398|Streptacidiphilus	201174|Actinobacteria	C	Phosphoenolpyruvate carboxylase	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
GDHHQS2_k127_2453734_0	561175.KB894098_gene5360	6.863e-86	288.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EGNQ@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
GDHHQS2_k127_2453734_1	1120949.KB903312_gene631	2.544e-50	182.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
GDHHQS2_k127_2453734_2	675635.Psed_3596	8.833e-14	80.0	2DGKW@1|root,2ZWET@2|Bacteria,2HSG2@201174|Actinobacteria,4EDKS@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2464904_0	675635.Psed_6538	4.085e-122	404.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4DZME@85010|Pseudonocardiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
GDHHQS2_k127_2464904_2	1121936.AUHI01000004_gene1465	3.525e-06	59.0	COG3480@1|root,COG3480@2|Bacteria,1TRUF@1239|Firmicutes,4HBAY@91061|Bacilli	91061|Bacilli	T	Belongs to the peptidase S16 family	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
GDHHQS2_k127_2464904_1	565045.NOR51B_295	9.336e-18	88.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,1RNQR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Lysophospholipase	ynbC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Methyltransf_20
GDHHQS2_k127_2473283_2	246196.MSMEI_6692	9.069e-06	47.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,232XE@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
GDHHQS2_k127_2473283_1	1298858.AUEL01000005_gene1313	1.868e-51	195.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2U1S4@28211|Alphaproteobacteria,43NMJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS2_k127_2473283_0	1121924.ATWH01000007_gene2175	5.722e-99	334.0	COG0044@1|root,COG0044@2|Bacteria,2IARA@201174|Actinobacteria,4FP5T@85023|Microbacteriaceae	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
GDHHQS2_k127_2475793_1	1206101.AZXC01000001_gene4552	1.225e-21	95.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
GDHHQS2_k127_2475793_0	585531.HMPREF0063_11295	2.702e-92	319.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4DNMV@85009|Propionibacteriales	201174|Actinobacteria	H	Mur ligase middle domain	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
GDHHQS2_k127_250978_1	1385519.N801_17210	4.805e-21	104.0	2EVIQ@1|root,33NYW@2|Bacteria,2IIIZ@201174|Actinobacteria	201174|Actinobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase
GDHHQS2_k127_250978_0	356851.JOAN01000007_gene4199	2.754e-46	170.0	COG2315@1|root,COG2315@2|Bacteria,2HR7I@201174|Actinobacteria,4DFE0@85008|Micromonosporales	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
GDHHQS2_k127_2514510_1	1068980.ARVW01000001_gene7811	5.736e-95	329.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4DZV3@85010|Pseudonocardiales	201174|Actinobacteria	EU	Dipeptidyl aminopeptidase acylaminoacyl peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
GDHHQS2_k127_2514510_0	525909.Afer_1537	1.014e-112	372.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CMVG@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
GDHHQS2_k127_2514652_0	1122917.KB899664_gene2860	1.259e-22	102.0	COG1595@1|root,COG1595@2|Bacteria,1VB37@1239|Firmicutes,4HMZ2@91061|Bacilli,26RCC@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigY	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
GDHHQS2_k127_2517423_0	639283.Snov_0200	6.462e-52	199.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3F1EG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
GDHHQS2_k127_2517423_1	756272.Plabr_4240	1.381e-39	150.0	COG3836@1|root,COG3836@2|Bacteria,2IZ23@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
GDHHQS2_k127_2519919_0	1380390.JIAT01000009_gene1138	9.601e-121	402.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4CPM3@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
GDHHQS2_k127_2519919_5	28444.JODQ01000006_gene66	1.486e-05	58.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria,4EIBR@85012|Streptosporangiales	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C
GDHHQS2_k127_2519919_4	1035308.AQYY01000002_gene599	7.239e-16	86.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	DUF3662,FHA,Yop-YscD_cpl
GDHHQS2_k127_2519919_3	1229780.BN381_70016	1.56e-17	87.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,3UWWG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	T	Forkhead associated domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
GDHHQS2_k127_2519919_2	525909.Afer_0090	5.599e-52	193.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CN1S@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Sigma factor PP2C-like phosphatases	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
GDHHQS2_k127_2519919_1	1132441.KI519455_gene3258	9.642e-57	215.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,1W7JX@1268|Micrococcaceae	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
GDHHQS2_k127_2549489_0	1134912.AJTV01000038_gene3330	8.887e-146	471.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,36Y2W@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
GDHHQS2_k127_2550721_3	649831.L083_5247	7.515e-20	91.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
GDHHQS2_k127_2550721_0	1206726.BAFV01000065_gene4567	4.329e-63	222.0	COG3801@1|root,COG3801@2|Bacteria,2IQGZ@201174|Actinobacteria,4G260@85025|Nocardiaceae	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
GDHHQS2_k127_2550721_1	172088.AUGA01000004_gene3958	5.995e-30	124.0	COG3795@1|root,COG3795@2|Bacteria,1N32U@1224|Proteobacteria,2UFVV@28211|Alphaproteobacteria,3JYW1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
GDHHQS2_k127_2550721_2	1380390.JIAT01000009_gene653	1.05e-21	101.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4CS3T@84995|Rubrobacteria	84995|Rubrobacteria	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_255082_3	203119.Cthe_2077	8.52e-30	124.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia	186801|Clostridia	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
GDHHQS2_k127_255082_2	548477.HMPREF0294_1503	1.214e-39	156.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,22KCY@1653|Corynebacteriaceae	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
GDHHQS2_k127_255082_5	1410622.JNKY01000018_gene664	8.076e-12	73.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,27J0Y@186928|unclassified Lachnospiraceae	186801|Clostridia	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
GDHHQS2_k127_255082_1	290512.Paes_1580	9.368e-83	288.0	COG0057@1|root,COG0057@2|Bacteria,1FDJ0@1090|Chlorobi	1090|Chlorobi	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
GDHHQS2_k127_255082_0	880073.Calab_3781	3.002e-137	444.0	COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
GDHHQS2_k127_255082_4	67352.JODS01000003_gene1865	9.167e-21	95.0	COG1950@1|root,COG1950@2|Bacteria,2IHP5@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
GDHHQS2_k127_2558269_0	43354.JOIJ01000006_gene1873	2.477e-105	353.0	COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria,4EA10@85010|Pseudonocardiales	201174|Actinobacteria	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
GDHHQS2_k127_257469_0	1445613.JALM01000064_gene1337	2.048e-143	469.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4E29E@85010|Pseudonocardiales	201174|Actinobacteria	E	GMC oxidoreductase	alkJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
GDHHQS2_k127_2574836_1	1123320.KB889698_gene9323	3.892e-68	249.0	COG2133@1|root,COG3055@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Calx-beta,GSDH,Laminin_G_3,Malectin,PKD
GDHHQS2_k127_2574836_2	1229780.BN381_470014	2.329e-21	108.0	COG1404@1|root,COG5184@1|root,COG1404@2|Bacteria,COG5184@2|Bacteria,2IG31@201174|Actinobacteria,3UXAU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	DOZ	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,RCC1,RCC1_2,SLH
GDHHQS2_k127_2574836_0	649638.Trad_2941	4.376e-87	295.0	COG1940@1|root,COG1940@2|Bacteria,1WKZ2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	GK	ROK family	ppgK	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
GDHHQS2_k127_2579774_0	469383.Cwoe_3273	1.023e-49	183.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4CQI8@84995|Rubrobacteria	84995|Rubrobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
GDHHQS2_k127_2579774_1	136273.GY22_04980	9.093e-49	183.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,1W9CE@1268|Micrococcaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
GDHHQS2_k127_2586099_0	525909.Afer_1266	4.462e-86	292.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4CN13@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
GDHHQS2_k127_2586099_3	1035308.AQYY01000001_gene3368	8.093e-46	176.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,2629S@186807|Peptococcaceae	186801|Clostridia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
GDHHQS2_k127_2586099_4	570268.ANBB01000002_gene395	1.053e-41	158.0	COG2318@1|root,COG2318@2|Bacteria,2I1DJ@201174|Actinobacteria,4EK4Y@85012|Streptosporangiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
GDHHQS2_k127_2586099_6	471852.Tcur_3381	7.138e-21	95.0	COG2154@1|root,COG2154@2|Bacteria,2IKXR@201174|Actinobacteria	201174|Actinobacteria	H	dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
GDHHQS2_k127_2586099_5	1463853.JOHW01000005_gene4018	2.413e-29	124.0	COG2912@1|root,COG2912@2|Bacteria,2GMER@201174|Actinobacteria	201174|Actinobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
GDHHQS2_k127_2586099_1	134676.ACPL_1417	1.124e-74	261.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4D9EW@85008|Micromonosporales	201174|Actinobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
GDHHQS2_k127_2586099_2	1121877.JQKF01000022_gene2275	3.579e-60	220.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4CP58@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
GDHHQS2_k127_2596508_0	1214242.B446_08820	1.588e-57	203.0	COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
GDHHQS2_k127_2596508_1	35754.JNYJ01000005_gene5640	1.859e-44	167.0	COG2380@1|root,COG2380@2|Bacteria,2I8F9@201174|Actinobacteria,4DA01@85008|Micromonosporales	201174|Actinobacteria	S	COGs COG2380 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2621734_0	42256.RradSPS_0430	3.439e-07	52.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4CPUE@84995|Rubrobacteria	84995|Rubrobacteria	C	PFAM Transketolase central region	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS2_k127_262236_1	1449058.JQKT01000007_gene620	2.706e-28	117.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria,4FR1N@85023|Microbacteriaceae	201174|Actinobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
GDHHQS2_k127_262236_2	1121877.JQKF01000001_gene1300	2.472e-05	53.0	2E3FZ@1|root,31FAR@2|Bacteria,2HGRD@201174|Actinobacteria,4CNTW@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_262236_0	1313172.YM304_33560	6.907e-101	336.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4CNE8@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Myo-inositol-1-phosphate synthase	ino1	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
GDHHQS2_k127_26350_3	1449355.JQNR01000005_gene5821	2.398e-06	60.0	29V0V@1|root,30GDY@2|Bacteria,2ICUU@201174|Actinobacteria	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
GDHHQS2_k127_26350_1	1313172.YM304_11780	5.387e-34	140.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
GDHHQS2_k127_26350_0	1041522.MCOL_V200240	9.421e-36	141.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,2374Z@1762|Mycobacteriaceae	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS2_k127_26350_4	298654.FraEuI1c_3399	0.0001178	46.0	COG0778@1|root,COG0778@2|Bacteria,2GM9M@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS2_k127_26350_2	208444.JNYY01000001_gene5579	3.522e-17	83.0	COG2345@1|root,COG2345@2|Bacteria,2HCEF@201174|Actinobacteria,4E2MZ@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GDHHQS2_k127_2644196_0	1342299.Z947_120	5.428e-182	574.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
GDHHQS2_k127_2644196_1	643562.Daes_0128	2.41e-08	61.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2M800@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
GDHHQS2_k127_264731_0	1382306.JNIM01000001_gene3964	1.969e-116	396.0	COG1123@1|root,COG4172@2|Bacteria,2GBJ7@200795|Chloroflexi	200795|Chloroflexi	P	COGs COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
GDHHQS2_k127_2667697_2	521003.COLINT_03515	0.0005033	50.0	COG3745@1|root,COG3745@2|Bacteria,2HUXG@201174|Actinobacteria,4CVY6@84998|Coriobacteriia	84998|Coriobacteriia	U	Flp pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ChapFlgA,RcpC,SAF
GDHHQS2_k127_2667697_0	1120946.AUBF01000007_gene647	5.721e-17	93.0	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4D3TS@85005|Actinomycetales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
GDHHQS2_k127_2667697_1	1408424.JHYI01000019_gene3086	8.312e-13	76.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,4HAQM@91061|Bacilli,1ZBDR@1386|Bacillus	91061|Bacilli	U	COG4962 Flp pilus assembly protein, ATPase CpaF	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
GDHHQS2_k127_2691209_0	105422.BBPM01000001_gene4828	2.539e-152	505.0	COG0339@1|root,COG0339@2|Bacteria,2GM2Z@201174|Actinobacteria,2NF2Z@228398|Streptacidiphilus	201174|Actinobacteria	E	Peptidase family M3	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
GDHHQS2_k127_2713042_0	203119.Cthe_0182	2.388e-117	383.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3WGXE@541000|Ruminococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
GDHHQS2_k127_2713042_1	862514.HMPREF0623_0710	6.272e-37	145.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,4H9PT@91061|Bacilli,3F3VG@33958|Lactobacillaceae	91061|Bacilli	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
GDHHQS2_k127_273071_0	1395571.TMS3_0115075	9.305e-57	207.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Mandelate Racemase Muconate Lactonizing	-	-	4.2.1.156,4.2.1.42,5.1.2.2,5.5.1.25	ko:K01781,ko:K20023,ko:K20549	ko00053,ko00627,ko01120,map00053,map00627,map01120	-	R03791,R04161,R05608	RC00543,RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS2_k127_273071_1	1160707.AJIK01000005_gene1402	1.949e-33	141.0	COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4HCY5@91061|Bacilli,26D9S@186818|Planococcaceae	91061|Bacilli	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS2_k127_2732138_0	1128421.JAGA01000002_gene864	5.706e-94	314.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS2_k127_2732138_1	1122917.KB899659_gene5455	4.498e-07	57.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	3.2.1.8	ko:K01181,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	Big_3_2,Cadherin-like,Cohesin,DUF4347,Flg_new,He_PIG,HemolysinCabind,NEAT,SLH
GDHHQS2_k127_2765480_0	1283299.AUKG01000001_gene1980	7.68e-118	406.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CRTD@84995|Rubrobacteria	84995|Rubrobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
GDHHQS2_k127_2765480_1	765420.OSCT_1040	2.464e-61	222.0	COG1612@1|root,COG1612@2|Bacteria,2G75U@200795|Chloroflexi,376ZK@32061|Chloroflexia	32061|Chloroflexia	O	PFAM cytochrome oxidase assembly	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
GDHHQS2_k127_2765480_2	47716.JOFH01000006_gene1854	0.0002295	48.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria	201174|Actinobacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
GDHHQS2_k127_2769810_1	926550.CLDAP_36880	5.253e-92	317.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
GDHHQS2_k127_2769810_0	595460.RRSWK_03757	0.0	1509.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
GDHHQS2_k127_2769810_3	58123.JOFJ01000026_gene2761	4.446e-20	97.0	COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria,4EJNW@85012|Streptosporangiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
GDHHQS2_k127_2769810_2	28042.GU90_08050	1.579e-20	95.0	COG0517@1|root,COG0517@2|Bacteria,2I3TG@201174|Actinobacteria,4EC77@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
GDHHQS2_k127_2775970_2	312284.A20C1_08869	2.816e-17	86.0	2B8RU@1|root,3221R@2|Bacteria,2IT3Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2775970_0	1120960.ATXG01000005_gene2512	6.848e-82	281.0	COG3384@1|root,COG3384@2|Bacteria,2GNCA@201174|Actinobacteria,4FRK0@85023|Microbacteriaceae	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	1.13.11.8	ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigB
GDHHQS2_k127_2775970_1	1500259.JQLD01000010_gene4819	2.344e-20	99.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2U8QU@28211|Alphaproteobacteria,4BJA0@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
GDHHQS2_k127_2780579_0	1123251.ATWM01000004_gene1974	4.545e-152	494.0	COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4FE6A@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
GDHHQS2_k127_2780579_3	1408422.JHYF01000011_gene3429	1.162e-08	67.0	COG1664@1|root,COG1664@2|Bacteria,1V1NS@1239|Firmicutes,24TEV@186801|Clostridia,36ME3@31979|Clostridiaceae	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2780579_1	1121877.JQKF01000009_gene570	3.488e-84	298.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
GDHHQS2_k127_2780579_2	398767.Glov_3126	2.557e-18	87.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
GDHHQS2_k127_2781579_0	1089550.ATTH01000001_gene1859	2.728e-148	479.0	COG0183@1|root,COG0183@2|Bacteria,4NE3Q@976|Bacteroidetes,1FJ5K@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Thiolase, C-terminal domain	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
GDHHQS2_k127_2781579_1	1211815.CBYP010000060_gene3116	5.551e-113	375.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4ES2H@85013|Frankiales	201174|Actinobacteria	F	SMART Metal-dependent phosphohydrolase, HD region	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
GDHHQS2_k127_2787341_1	351607.Acel_0894	2.812e-43	162.0	COG5276@1|root,COG5276@2|Bacteria,2IH2N@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
GDHHQS2_k127_2787341_0	1380394.JADL01000002_gene1393	5.628e-111	366.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2U2X9@28211|Alphaproteobacteria,2JTJW@204441|Rhodospirillales	204441|Rhodospirillales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
GDHHQS2_k127_2787341_2	991905.SL003B_1040	5.788e-13	69.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,4BRDF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system permease	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_2791429_1	483219.LILAB_24505	1.688e-101	346.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2YU5T@29|Myxococcales	28221|Deltaproteobacteria	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
GDHHQS2_k127_2791429_0	1123023.JIAI01000010_gene8570	2.542e-115	393.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4DY2E@85010|Pseudonocardiales	201174|Actinobacteria	J	elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
GDHHQS2_k127_2793955_2	1089544.KB912942_gene6733	5.621e-14	78.0	COG4448@1|root,COG4448@2|Bacteria,2GJA7@201174|Actinobacteria,4DYR1@85010|Pseudonocardiales	201174|Actinobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
GDHHQS2_k127_2793955_1	243164.DET1003	2.872e-19	101.0	COG5653@1|root,COG5653@2|Bacteria,2G6Z0@200795|Chloroflexi,34CZI@301297|Dehalococcoidia	301297|Dehalococcoidia	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
GDHHQS2_k127_2793955_0	477641.MODMU_5019	7.67e-23	101.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4ES4V@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_2796359_0	1123320.KB889675_gene4050	2.979e-180	576.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
GDHHQS2_k127_2796359_1	710686.Mycsm_06220	8.87e-52	194.0	293MU@1|root,2ZR3M@2|Bacteria,2IFCB@201174|Actinobacteria,238S9@1762|Mycobacteriaceae	201174|Actinobacteria	S	Superoxide dismutase	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
GDHHQS2_k127_2796359_2	485913.Krac_12122	1.665e-13	77.0	COG0681@1|root,COG0681@2|Bacteria,2G701@200795|Chloroflexi	200795|Chloroflexi	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
GDHHQS2_k127_2801976_2	1187851.A33M_3731	1.852e-63	229.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
GDHHQS2_k127_2801976_0	1313172.YM304_27600	9.069e-191	608.0	COG0031@1|root,COG0031@2|Bacteria,2IEI6@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2801976_1	1298863.AUEP01000005_gene2422	3.168e-72	267.0	COG0111@1|root,COG4198@1|root,COG0111@2|Bacteria,COG4198@2|Bacteria,2I94K@201174|Actinobacteria,4DT2I@85009|Propionibacteriales	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GDHHQS2_k127_2816120_1	562970.Btus_2300	2.933e-37	150.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,4HAQ9@91061|Bacilli,2787I@186823|Alicyclobacillaceae	91061|Bacilli	J	phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
GDHHQS2_k127_2816120_0	222534.KB893694_gene172	1.082e-40	157.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4ERRI@85013|Frankiales	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
GDHHQS2_k127_2825819_1	710111.FraQA3DRAFT_5857	1.517e-35	141.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4ERZM@85013|Frankiales	201174|Actinobacteria	S	Belongs to the CinA family	cinA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
GDHHQS2_k127_2825819_2	580340.Tlie_0852	2.076e-21	101.0	COG1514@1|root,COG1514@2|Bacteria,3TBEC@508458|Synergistetes	508458|Synergistetes	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
GDHHQS2_k127_2825819_0	266117.Rxyl_1423	4.48e-96	321.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4CPF2@84995|Rubrobacteria	84995|Rubrobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
GDHHQS2_k127_2828773_1	1122247.C731_4953	1.29e-31	132.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,2378P@1762|Mycobacteriaceae	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	garR	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
GDHHQS2_k127_2828773_0	1123229.AUBC01000004_gene3286	1.028e-46	177.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TRNE@28211|Alphaproteobacteria,3JR1K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	MA20_23320	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
GDHHQS2_k127_2828773_2	318424.EU78_26460	6.254e-19	94.0	29WVU@1|root,30IHF@2|Bacteria,2IECK@201174|Actinobacteria,233RY@1762|Mycobacteriaceae	201174|Actinobacteria	S	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
GDHHQS2_k127_2828980_1	981369.JQMJ01000003_gene7675	9.331e-05	47.0	COG0477@1|root,COG2814@2|Bacteria,2GMKX@201174|Actinobacteria,2NH4Y@228398|Streptacidiphilus	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
GDHHQS2_k127_2835636_0	1489678.RDMS_06105	1.965e-105	364.0	COG0022@1|root,COG0022@2|Bacteria,1WIJK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS2_k127_2835636_1	1157490.EL26_23165	2.563e-70	261.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4H9PQ@91061|Bacilli,279FE@186823|Alicyclobacillaceae	91061|Bacilli	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
GDHHQS2_k127_2848725_0	158190.SpiGrapes_2657	1.848e-46	179.0	COG0041@1|root,COG0041@2|Bacteria,2J8QD@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
GDHHQS2_k127_2848725_1	309801.trd_1626	2.932e-30	125.0	COG3836@1|root,COG3836@2|Bacteria,2G925@200795|Chloroflexi,27YE5@189775|Thermomicrobia	189775|Thermomicrobia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
GDHHQS2_k127_2860500_0	1121877.JQKF01000001_gene1306	1.252e-138	450.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4CMQU@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
GDHHQS2_k127_2860500_1	1444310.JANV01000115_gene4517	2.61e-07	53.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
GDHHQS2_k127_2862165_2	552811.Dehly_1197	1.737e-32	136.0	COG4826@1|root,COG4826@2|Bacteria,2GBWN@200795|Chloroflexi,34D50@301297|Dehalococcoidia	301297|Dehalococcoidia	M	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
GDHHQS2_k127_2862165_3	1071085.KK033114_gene256	9.556e-23	104.0	COG0346@1|root,arCOG02706@2157|Archaea,2XWWF@28890|Euryarchaeota,23VFH@183963|Halobacteria	183963|Halobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
GDHHQS2_k127_2862165_1	926569.ANT_29290	3.529e-38	157.0	COG0438@1|root,COG2227@1|root,COG0438@2|Bacteria,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_56,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_31
GDHHQS2_k127_2862165_0	1306174.JODP01000001_gene4672	8.738e-96	321.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_2866149_0	935866.JAER01000010_gene4131	5.433e-163	527.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DPKK@85009|Propionibacteriales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS2_k127_2869600_0	1463887.KL589954_gene7191	1.103e-22	104.0	COG2318@1|root,COG2318@2|Bacteria,2GXK3@201174|Actinobacteria	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
GDHHQS2_k127_2872817_2	710686.Mycsm_06335	7.601e-05	50.0	COG1366@1|root,COG1366@2|Bacteria,2HPDH@201174|Actinobacteria,23AV0@1762|Mycobacteriaceae	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsfB	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
GDHHQS2_k127_2872817_0	706587.Desti_3425	3.05e-113	373.0	COG2152@1|root,COG2152@2|Bacteria,1MX8M@1224|Proteobacteria,42QDF@68525|delta/epsilon subdivisions,2WMG5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	beta-1,4-mannooligosaccharide phosphorylase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130
GDHHQS2_k127_2872817_1	408672.NBCG_00751	1.147e-19	90.0	COG0778@1|root,COG0778@2|Bacteria,2I5BC@201174|Actinobacteria,4DSK6@85009|Propionibacteriales	201174|Actinobacteria	L	Domain of unknown function (DUF1918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1918
GDHHQS2_k127_2872817_3	1382356.JQMP01000001_gene915	0.0005322	49.0	COG0589@1|root,COG0589@2|Bacteria,2G8FB@200795|Chloroflexi,27YAE@189775|Thermomicrobia	189775|Thermomicrobia	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
GDHHQS2_k127_2879913_3	869210.Marky_1321	6.511e-17	84.0	COG0419@1|root,COG0419@2|Bacteria,1WJ38@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	ATPase involved in DNA repair	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
GDHHQS2_k127_2879913_1	287986.DV20_15915	1.594e-93	319.0	COG0420@1|root,COG0420@2|Bacteria,2GK9R@201174|Actinobacteria,4DYUN@85010|Pseudonocardiales	201174|Actinobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
GDHHQS2_k127_2879913_0	1122182.KB903837_gene3715	2.095e-221	699.0	COG0433@1|root,COG0433@2|Bacteria,2I0H5@201174|Actinobacteria,4D9TP@85008|Micromonosporales	201174|Actinobacteria	S	COG0433 Predicted ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	-
GDHHQS2_k127_2879913_4	561229.Dd1591_2231	1.88e-08	61.0	2EAVJ@1|root,334WZ@2|Bacteria,1NEMG@1224|Proteobacteria,1ST2E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2879913_2	760117.JN27_07085	9.815e-75	259.0	COG2133@1|root,COG2133@2|Bacteria,1R86D@1224|Proteobacteria,2VTBE@28216|Betaproteobacteria,475Z6@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
GDHHQS2_k127_2884173_1	479432.Sros_4170	2.239e-13	77.0	COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS2_k127_2884173_0	118163.Ple7327_1113	2.113e-96	330.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,3VI0U@52604|Pleurocapsales	1117|Cyanobacteria	C	PFAM Alanine dehydrogenase PNT, C-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
GDHHQS2_k127_2900063_0	745776.DGo_CA2804	6.258e-33	140.0	COG0294@1|root,COG0294@2|Bacteria,1WJ2K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
GDHHQS2_k127_2906956_2	880073.Calab_3584	1.287e-55	199.0	COG0297@1|root,COG0297@2|Bacteria,2NQKG@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
GDHHQS2_k127_2906956_0	1380393.JHVP01000005_gene3587	1.267e-178	567.0	COG0151@1|root,COG0151@2|Bacteria,2I624@201174|Actinobacteria,4EXFF@85013|Frankiales	201174|Actinobacteria	F	Carbamoyl-phosphate synthase L chain, ATP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2906956_1	710696.Intca_0098	2.359e-88	304.0	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
GDHHQS2_k127_2913808_0	1229780.BN381_60088	6.048e-144	463.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,3UX6A@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	4Fe-4S dicluster domain	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
GDHHQS2_k127_2916620_0	309807.SRU_0080	2.03e-56	202.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,4NDWV@976|Bacteroidetes,1FJJA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Phosphoglucose isomerase	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
GDHHQS2_k127_2918238_2	1137269.AZWL01000002_gene6387	2.687e-69	241.0	COG0745@1|root,COG0745@2|Bacteria,2I5E7@201174|Actinobacteria	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_2918238_1	1232410.KI421424_gene1795	2.202e-85	290.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	pgmB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576	2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6	ko:K01087,ko:K01194,ko:K01838,ko:K05342	ko00500,ko01100,map00500,map01100	-	R00010,R02727,R02728,R02778,R11310	RC00017,RC00049,RC00408	ko00000,ko00001,ko00537,ko01000	-	GH37,GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase
GDHHQS2_k127_2918238_0	1151122.AQYD01000007_gene402	3.14e-187	611.0	COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4FM83@85023|Microbacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
GDHHQS2_k127_2918238_3	1146883.BLASA_0300	2.709e-09	63.0	COG2030@1|root,COG2030@2|Bacteria,2GIXP@201174|Actinobacteria,4EV3S@85013|Frankiales	201174|Actinobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
GDHHQS2_k127_2920285_1	1133849.O3I_010390	2.746e-07	53.0	COG5646@1|root,COG5646@2|Bacteria,2IT4Y@201174|Actinobacteria,4G31R@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
GDHHQS2_k127_2920285_0	1122622.ATWJ01000008_gene2607	7.031e-88	299.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,4FJXN@85021|Intrasporangiaceae	201174|Actinobacteria	IT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
GDHHQS2_k127_292463_1	926569.ANT_29290	2.402e-43	163.0	COG0438@1|root,COG2227@1|root,COG0438@2|Bacteria,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_56,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_31
GDHHQS2_k127_292463_2	926550.CLDAP_16140	2.091e-37	163.0	COG1215@1|root,COG1215@2|Bacteria,2G6E4@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3,Glycos_transf_2
GDHHQS2_k127_292463_3	1499968.TCA2_5947	2.575e-18	100.0	COG0500@1|root,COG1216@1|root,COG1216@2|Bacteria,COG2226@2|Bacteria,1U21D@1239|Firmicutes,4IBI9@91061|Bacilli,270JI@186822|Paenibacillaceae	91061|Bacilli	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
GDHHQS2_k127_292463_0	1385521.N803_02320	2.453e-99	346.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4FHA0@85021|Intrasporangiaceae	201174|Actinobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
GDHHQS2_k127_292463_4	1121937.AUHJ01000020_gene1258	1.603e-12	78.0	COG2159@1|root,COG2159@2|Bacteria,1QDV1@1224|Proteobacteria,1RYCT@1236|Gammaproteobacteria,469EG@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
GDHHQS2_k127_2926852_0	1229780.BN381_310072	7.971e-65	225.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,3UWMR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
GDHHQS2_k127_2926852_1	1515746.HR45_18705	0.0002251	51.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,1RS7W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	proteins of the AP superfamily	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phosphodiest
GDHHQS2_k127_2936131_2	479434.Sthe_1081	2.708e-64	239.0	COG1131@1|root,COG1131@2|Bacteria,2G6B8@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS2_k127_2936131_4	1136417.AZWE01000001_gene3867	2.37e-21	107.0	COG1277@1|root,COG1277@2|Bacteria,2GKKP@201174|Actinobacteria,4D8U0@85008|Micromonosporales	201174|Actinobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
GDHHQS2_k127_2936131_1	356851.JOAN01000032_gene2807	1.712e-79	275.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria,4DAYJ@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS2_k127_2936131_7	192952.MM_1264	6.265e-06	54.0	COG5513@1|root,arCOG03547@2157|Archaea,2Y4G7@28890|Euryarchaeota,2NB6K@224756|Methanomicrobia	224756|Methanomicrobia	G	serine-type aminopeptidase activity	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	-
GDHHQS2_k127_2936131_3	1173263.Syn7502_00303	1.642e-33	147.0	COG4124@1|root,COG4124@2|Bacteria,1GD5A@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2936131_5	1479623.JHEL01000009_gene1772	1.902e-11	77.0	COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4FKNT@85023|Microbacteriaceae	201174|Actinobacteria	O	N-terminal Region. This family is found at the N-terminus of a number of subtilisins. It is cleaved prior to activation of the enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Inhibitor_I9,PA,Peptidase_S8,SLH,fn3_5
GDHHQS2_k127_2936131_0	1121377.KB906401_gene3384	4.446e-152	518.0	COG3903@1|root,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,DUF4062,GerE,NB-ARC,TPR_12
GDHHQS2_k127_2936131_6	710696.Intca_3045	1.731e-07	55.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria,4FJ4K@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_2943371_0	1121934.AUDX01000011_gene315	9.018e-37	146.0	COG1210@1|root,COG1210@2|Bacteria,2I2EW@201174|Actinobacteria,4FKKH@85023|Microbacteriaceae	201174|Actinobacteria	M	Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
GDHHQS2_k127_2943371_1	1301098.PKB_0533	1.106e-30	129.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
GDHHQS2_k127_2947248_0	675635.Psed_4075	9.615e-40	153.0	COG3832@1|root,COG3832@2|Bacteria,2GQIZ@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_2947248_1	1120949.KB903294_gene4318	3.233e-33	132.0	COG0640@1|root,COG0640@2|Bacteria,2ISNZ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
GDHHQS2_k127_2954863_3	981369.JQMJ01000004_gene3303	1.208e-14	80.0	COG0631@1|root,COG0789@1|root,COG0631@2|Bacteria,COG0789@2|Bacteria,2GM6B@201174|Actinobacteria,2NF2H@228398|Streptacidiphilus	201174|Actinobacteria	KT	Protein phosphatase 2C	prpH	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	MerR_1,PP2C,PP2C_2
GDHHQS2_k127_2954863_1	477641.MODMU_0382	3.226e-54	194.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria,4ETBT@85013|Frankiales	201174|Actinobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
GDHHQS2_k127_2954863_0	1128421.JAGA01000003_gene3456	6.288e-184	584.0	COG2873@1|root,COG2873@2|Bacteria,2NQN4@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	cysD	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
GDHHQS2_k127_2954863_2	118161.KB235922_gene1598	2.467e-26	111.0	COG0500@1|root,COG2226@2|Bacteria,1G2V9@1117|Cyanobacteria	1117|Cyanobacteria	Q	PFAM sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
GDHHQS2_k127_2960586_0	357808.RoseRS_4206	6.653e-27	121.0	COG0526@1|root,COG0526@2|Bacteria,2GACV@200795|Chloroflexi,375FU@32061|Chloroflexia	32061|Chloroflexia	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
GDHHQS2_k127_29622_0	1304880.JAGB01000001_gene962	6.697e-76	267.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_29622_2	1303692.SFUL_1675	2.013e-43	165.0	28JRZ@1|root,2Z9HI@2|Bacteria,2H9EF@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
GDHHQS2_k127_29622_1	1114959.SZMC14600_19314	1.053e-49	184.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4DYVB@85010|Pseudonocardiales	201174|Actinobacteria	I	PFAM Enoyl-CoA hydratase isomerase	chcB	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
GDHHQS2_k127_296872_0	395963.Bind_0259	2.411e-80	281.0	COG2706@1|root,COG2706@2|Bacteria,1NG69@1224|Proteobacteria,2UZGA@28211|Alphaproteobacteria,3NCBV@45404|Beijerinckiaceae	28211|Alphaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
GDHHQS2_k127_296872_1	1313172.YM304_38610	9.308e-54	194.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4CNQN@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_2975016_0	1386089.N865_01800	6.179e-42	161.0	COG1595@1|root,COG1595@2|Bacteria,2IK5Q@201174|Actinobacteria,4FI3G@85021|Intrasporangiaceae	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_2975016_1	1048339.KB913029_gene3755	2.76e-30	127.0	2FHWH@1|root,349PK@2|Bacteria,2GYIN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_297522_1	1122622.ATWJ01000009_gene3029	3.651e-31	124.0	COG1793@1|root,COG1793@2|Bacteria,2I2EA@201174|Actinobacteria,4FK0W@85021|Intrasporangiaceae	201174|Actinobacteria	L	Catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA	ligC	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
GDHHQS2_k127_297522_0	266940.Krad_1958	1.661e-57	207.0	COG0412@1|root,COG0412@2|Bacteria,2GTZG@201174|Actinobacteria	201174|Actinobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
GDHHQS2_k127_2975945_1	479432.Sros_6203	6.416e-113	372.0	COG2378@1|root,COG2378@2|Bacteria,2GIZC@201174|Actinobacteria,4EG3V@85012|Streptosporangiales	201174|Actinobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
GDHHQS2_k127_2975945_0	1179773.BN6_17560	2.907e-140	453.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DXJD@85010|Pseudonocardiales	201174|Actinobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990,ko:K18232	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC_tran,DUF4162
GDHHQS2_k127_2988750_2	1276920.ADIAG_03148	3.288e-17	85.0	COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria,1W994@1268|Micrococcaceae	201174|Actinobacteria	K	Transcriptional regulator	padR	-	-	-	-	-	-	-	-	-	-	-	PadR
GDHHQS2_k127_2988750_1	1121272.KB903251_gene824	1.092e-29	133.0	COG0454@1|root,COG0456@2|Bacteria,2IAC7@201174|Actinobacteria,4DJN8@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	aac	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	2.3.1.59	ko:K17840	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_9
GDHHQS2_k127_2988750_0	234267.Acid_5969	3.827e-125	406.0	COG0076@1|root,COG0076@2|Bacteria,3Y365@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
GDHHQS2_k127_2992951_0	1123367.C666_01495	1.682e-150	497.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,2KVIK@206389|Rhodocyclales	206389|Rhodocyclales	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
GDHHQS2_k127_2992951_2	1223543.GP2_009_00380	0.000154	49.0	2E5E7@1|root,33065@2|Bacteria,2IN6X@201174|Actinobacteria,4GEZ6@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2992951_1	1236541.BALL01000027_gene3112	1.123e-51	189.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,1RSCY@1236|Gammaproteobacteria,2QAGU@267890|Shewanellaceae	1236|Gammaproteobacteria	F	Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively	rihA	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047405,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.2.2.1	ko:K01239,ko:K01250	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_0645,iECSE_1348.ECSE_0721,iEcE24377_1341.EcE24377A_0679,iSbBS512_1146.SbBS512_E0598	IU_nuc_hydro
GDHHQS2_k127_2996160_0	1172185.KB911511_gene3008	4.105e-49	195.0	COG3886@1|root,COG3886@2|Bacteria,2IB57@201174|Actinobacteria,4G7YH@85025|Nocardiaceae	201174|Actinobacteria	L	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_2999378_1	251229.Chro_3842	7.284e-10	70.0	COG3861@1|root,COG3861@2|Bacteria,1G4XJ@1117|Cyanobacteria,3VNFX@52604|Pleurocapsales	1117|Cyanobacteria	S	SPTR Signal transduction histidine kinase (STHK), LytS	-	-	-	-	-	-	-	-	-	-	-	-	YflT
GDHHQS2_k127_2999378_0	1122138.AQUZ01000018_gene7443	4.159e-46	172.0	COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
GDHHQS2_k127_3002169_2	796945.HMPREF1145_1022	1.899e-08	57.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,2PT23@265975|Oribacterium	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_3002169_1	479434.Sthe_2886	2.033e-34	145.0	COG4177@1|root,COG4177@2|Bacteria,2G8KF@200795|Chloroflexi,27YZG@189775|Thermomicrobia	189775|Thermomicrobia	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_3002169_0	1448860.BBJO01000042_gene1758	8.081e-57	214.0	COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,23UWK@183963|Halobacteria	183963|Halobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
GDHHQS2_k127_3030778_4	880073.Calab_1956	4.01e-17	86.0	COG0204@1|root,COG0204@2|Bacteria,2NPUH@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
GDHHQS2_k127_3030778_3	670487.Ocepr_1567	1.167e-21	102.0	COG0212@1|root,COG0212@2|Bacteria,1WK90@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
GDHHQS2_k127_3030778_1	258052.JNYV01000003_gene4972	4.857e-33	135.0	COG3576@1|root,COG3576@2|Bacteria,2I2U7@201174|Actinobacteria	201174|Actinobacteria	C	Pfam Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
GDHHQS2_k127_3030778_2	1229780.BN381_130349	6.678e-28	123.0	COG2755@1|root,COG2755@2|Bacteria,2HFQG@201174|Actinobacteria,3UXQ1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
GDHHQS2_k127_3030778_0	745411.B3C1_11252	8.631e-67	235.0	COG0813@1|root,COG0813@2|Bacteria,1MUW6@1224|Proteobacteria,1RMMA@1236|Gammaproteobacteria,1J9KR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphorylase superfamily	deoD	GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1997,iB21_1397.B21_04226,iE2348C_1286.E2348C_4682,iEC042_1314.EC042_4881,iECABU_c1320.ECABU_c50190,iECBD_1354.ECBD_3636,iECB_1328.ECB_04260,iECD_1391.ECD_04260,iECED1_1282.ECED1_5255,iECIAI39_1322.ECIAI39_4916,iECNA114_1301.ECNA114_4626,iECO26_1355.ECO26_5590,iECOK1_1307.ECOK1_4950,iECP_1309.ECP_4768,iEcolC_1368.EcolC_3672,iLF82_1304.LF82_0467,iNRG857_1313.NRG857_22170,iPC815.YPO0440,iSFV_1184.SFV_4418,iSF_1195.SF4416,iSFxv_1172.SFxv_4809,iS_1188.S4687,iUMN146_1321.UM146_22680,iUMNK88_1353.UMNK88_5303,iUTI89_1310.UTI89_C5155,ic_1306.c5468	PNP_UDP_1
GDHHQS2_k127_3040250_3	67267.JNXT01000104_gene4112	2.792e-12	68.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_3040250_0	525909.Afer_0366	5.625e-168	541.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
GDHHQS2_k127_3040250_2	1313172.YM304_04080	7.668e-31	131.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4CN4G@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
GDHHQS2_k127_3040250_1	1229780.BN381_450005	4.482e-71	241.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,3UWJQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
GDHHQS2_k127_3040525_0	471852.Tcur_4810	6.438e-96	328.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4EGU0@85012|Streptosporangiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
GDHHQS2_k127_3040525_1	926569.ANT_02040	1.3e-41	158.0	COG1012@1|root,COG1012@2|Bacteria,2G61H@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
GDHHQS2_k127_3048556_0	1313172.YM304_35690	1.172e-107	351.0	COG5012@1|root,COG5012@2|Bacteria,2IEGQ@201174|Actinobacteria	201174|Actinobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
GDHHQS2_k127_3048556_1	748247.AZKH_p0168	4.398e-64	226.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
GDHHQS2_k127_3048556_2	314271.RB2654_04606	4.026e-10	67.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria,2UBTM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
GDHHQS2_k127_3066211_1	710686.Mycsm_02443	1.129e-70	243.0	COG0531@1|root,COG0531@2|Bacteria,2I49Z@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	AA_permease,AA_permease_2
GDHHQS2_k127_3066211_0	1122221.JHVI01000001_gene1935	1.357e-206	653.0	COG0174@1|root,COG0174@2|Bacteria,1WM8G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
GDHHQS2_k127_3083157_1	509635.N824_21320	1.715e-30	124.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	ilvG	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1820	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
GDHHQS2_k127_3083157_0	1382356.JQMP01000004_gene529	3.592e-45	173.0	COG1968@1|root,COG1968@2|Bacteria,2G6F7@200795|Chloroflexi,27Y0J@189775|Thermomicrobia	189775|Thermomicrobia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
GDHHQS2_k127_3085002_0	1236902.ANAS01000037_gene5387	6.657e-142	463.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4EH24@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
GDHHQS2_k127_3085002_1	639030.JHVA01000001_gene1089	8.654e-38	151.0	COG4221@1|root,COG4221@2|Bacteria,3Y6ZB@57723|Acidobacteria,2JKUG@204432|Acidobacteriia	204432|Acidobacteriia	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
GDHHQS2_k127_3085002_2	369723.Strop_0557	2.481e-19	95.0	2DS49@1|root,33EFP@2|Bacteria,2H1NB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3092383_2	1177154.Y5S_02273	5.647e-05	50.0	2EUZ6@1|root,33NED@2|Bacteria	2|Bacteria	S	Flp/Fap pilin component	-	-	-	-	-	-	-	-	-	-	-	-	Flp_Fap
GDHHQS2_k127_3092383_0	670487.Ocepr_0722	6.464e-36	144.0	COG2197@1|root,COG2197@2|Bacteria,1WI4W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_3092383_1	649638.Trad_1796	7.072e-24	113.0	COG3829@1|root,COG4585@1|root,COG3829@2|Bacteria,COG4585@2|Bacteria,1WJNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8
GDHHQS2_k127_3096892_0	390989.JOEG01000001_gene4974	2.952e-51	190.0	COG2345@1|root,COG2345@2|Bacteria,2IAWJ@201174|Actinobacteria,4DFSP@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_IclR
GDHHQS2_k127_3096892_1	570952.ATVH01000002_gene941	2.017e-23	106.0	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,2TY3M@28211|Alphaproteobacteria,2JYYN@204441|Rhodospirillales	204441|Rhodospirillales	H	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3099977_0	436229.JOEH01000004_gene55	9.193e-214	676.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,2NM7I@228398|Streptacidiphilus	201174|Actinobacteria	J	Aminoacyl-tRNA editing domain	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
GDHHQS2_k127_3099977_1	1306406.ASHX01000002_gene4932	1.68e-50	184.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
GDHHQS2_k127_3099977_2	1211815.CBYP010000046_gene886	1.709e-11	69.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4ES1V@85013|Frankiales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
GDHHQS2_k127_3106693_2	324925.Ppha_0843	2.574e-09	58.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
GDHHQS2_k127_3106693_1	247634.GPB2148_2901	2.533e-18	86.0	COG0404@1|root,COG0404@2|Bacteria,1N705@1224|Proteobacteria,1S5H7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	GCV_T,GCV_T_C
GDHHQS2_k127_3106693_0	1096769.Pelub83DRAFT_0358	3.553e-77	269.0	COG0404@1|root,COG0404@2|Bacteria,1N705@1224|Proteobacteria,2TQT7@28211|Alphaproteobacteria,4BRBA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C,SnoaL_2
GDHHQS2_k127_3116088_0	981369.JQMJ01000003_gene7281	4.479e-189	606.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,2NG50@228398|Streptacidiphilus	201174|Actinobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
GDHHQS2_k127_311783_0	1380390.JIAT01000014_gene6134	1.313e-60	224.0	COG0348@1|root,COG0348@2|Bacteria,2I6I5@201174|Actinobacteria,4CS5U@84995|Rubrobacteria	84995|Rubrobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3120567_1	263358.VAB18032_20110	1.772e-07	54.0	COG5401@1|root,COG5401@2|Bacteria,2IK3M@201174|Actinobacteria,4DDDD@85008|Micromonosporales	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
GDHHQS2_k127_3120567_0	765420.OSCT_2228	3.24e-69	249.0	COG4640@1|root,COG4640@2|Bacteria	2|Bacteria	KT	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160,YARHG,zinc_ribbon_2
GDHHQS2_k127_3129462_0	196164.23494828	8.679e-50	190.0	COG3293@1|root,COG3293@2|Bacteria,2ICBV@201174|Actinobacteria,22QF5@1653|Corynebacteriaceae	201174|Actinobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
GDHHQS2_k127_3130994_1	1380355.JNIJ01000019_gene4583	6.562e-14	78.0	COG0251@1|root,COG0251@2|Bacteria,1Q7E6@1224|Proteobacteria,2UTJ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
GDHHQS2_k127_3130994_0	1120983.KB894571_gene2473	2.167e-76	261.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,1JPAC@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_3131313_1	1547437.LL06_19690	1.07e-20	94.0	COG0662@1|root,COG0662@2|Bacteria,1R1DU@1224|Proteobacteria,2TZ1H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_3131313_0	1298867.AUES01000089_gene2973	4.755e-94	320.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,3K2G8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
GDHHQS2_k127_3161946_1	103733.JNYO01000005_gene8560	1.612e-24	115.0	COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria,4DZ2G@85010|Pseudonocardiales	201174|Actinobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,HisKA_3,PAS_4,Response_reg
GDHHQS2_k127_3161946_0	1385521.N803_14205	4.779e-71	247.0	COG0122@1|root,COG0122@2|Bacteria,2IPPK@201174|Actinobacteria,4FJWM@85021|Intrasporangiaceae	201174|Actinobacteria	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
GDHHQS2_k127_3168375_3	747365.Thena_0748	0.0002091	52.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	3.4.21.88	ko:K01356,ko:K22299	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03000,ko03400	-	-	-	HTH_19,HTH_3,HTH_31
GDHHQS2_k127_3168375_0	1283283.ATXA01000003_gene1646	1.921e-49	182.0	COG1595@1|root,COG1595@2|Bacteria,2IKQ7@201174|Actinobacteria,4EVJY@85013|Frankiales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
GDHHQS2_k127_3168375_4	33876.JNXY01000021_gene4676	0.0002217	52.0	2DW3A@1|root,33YCP@2|Bacteria,2GZ8M@201174|Actinobacteria	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
GDHHQS2_k127_3168375_2	749414.SBI_02609	1.204e-12	75.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
GDHHQS2_k127_3168375_1	1122138.AQUZ01000047_gene100	6.036e-13	77.0	COG5485@1|root,COG5485@2|Bacteria,2HPCH@201174|Actinobacteria,4DSK3@85009|Propionibacteriales	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
GDHHQS2_k127_3169698_1	1245471.PCA10_51360	1.229e-35	143.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,1S3SX@1236|Gammaproteobacteria,1YHMZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
GDHHQS2_k127_3169698_2	698761.RTCIAT899_CH06750	2.196e-19	91.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,4BFB4@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
GDHHQS2_k127_3169698_0	1429046.RR21198_0627	4.36e-42	160.0	COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria,4FUTW@85025|Nocardiaceae	201174|Actinobacteria	Q	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
GDHHQS2_k127_3177683_0	1229780.BN381_10212	5.443e-118	393.0	COG2304@1|root,COG2304@2|Bacteria,2HQ9B@201174|Actinobacteria,3UXG6@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_11
GDHHQS2_k127_3178136_3	1397278.AYMV01000010_gene74	6.721e-24	105.0	COG2188@1|root,COG2188@2|Bacteria,2IAW7@201174|Actinobacteria,4FSBJ@85023|Microbacteriaceae	201174|Actinobacteria	K	UTRA domain	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
GDHHQS2_k127_3178136_1	1125971.ASJB01000062_gene4349	1.301e-78	270.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4E1YY@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS2_k127_3178136_2	1231190.NA8A_16166	2.326e-63	226.0	COG1028@1|root,COG1028@2|Bacteria	1231190.NA8A_16166|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3178136_0	1123322.KB904658_gene1286	2.991e-166	536.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2GNEI@201174|Actinobacteria	201174|Actinobacteria	IQ	Rhamnulose-1-phosphate aldolase alcohol dehydrogenase	srlD	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,adh_short,adh_short_C2
GDHHQS2_k127_3186610_0	1128421.JAGA01000003_gene3380	1.869e-45	177.0	COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
GDHHQS2_k127_3186610_1	517417.Cpar_1840	3.07e-14	76.0	COG0642@1|root,COG2205@2|Bacteria,1FFHQ@1090|Chlorobi	1090|Chlorobi	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
GDHHQS2_k127_3186757_0	1246474.ANBE01000022_gene3888	5.071e-165	532.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4EGDA@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
GDHHQS2_k127_3186757_1	351607.Acel_2071	7.591e-75	262.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4ERKV@85013|Frankiales	201174|Actinobacteria	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
GDHHQS2_k127_3189926_2	469371.Tbis_1361	8.846e-15	76.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4E5KY@85010|Pseudonocardiales	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
GDHHQS2_k127_3189926_1	1229780.BN381_50149	4.901e-98	335.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,3UWCS@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
GDHHQS2_k127_3189926_0	443254.Marpi_1094	2.942e-144	467.0	COG0192@1|root,COG0192@2|Bacteria,2GCFC@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
GDHHQS2_k127_3189926_3	1121430.JMLG01000006_gene1735	5.406e-06	57.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,25ZXM@186807|Peptococcaceae	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
GDHHQS2_k127_3192971_0	1206729.BAFZ01000048_gene5141	6.14e-100	340.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4FYNR@85025|Nocardiaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
GDHHQS2_k127_3192971_1	1169154.KB897779_gene2949	3.036e-37	149.0	COG2211@1|root,COG2211@2|Bacteria,2I2X7@201174|Actinobacteria	201174|Actinobacteria	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
GDHHQS2_k127_3196090_1	981369.JQMJ01000004_gene4798	1.551e-39	160.0	COG0454@1|root,COG0456@2|Bacteria,2IACY@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_3196090_0	321332.CYB_0715	8.171e-199	627.0	COG1012@1|root,COG1012@2|Bacteria,1G2U1@1117|Cyanobacteria,1GYU6@1129|Synechococcus	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_3200781_1	1048339.KB913029_gene4731	3.252e-16	87.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4ESKG@85013|Frankiales	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
GDHHQS2_k127_3200781_0	351607.Acel_0900	6.685e-36	143.0	COG0327@1|root,COG0327@2|Bacteria,2GKHZ@201174|Actinobacteria,4ES0X@85013|Frankiales	201174|Actinobacteria	S	NIF3 (NGG1p interacting factor 3)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
GDHHQS2_k127_3200781_2	309807.SRU_2112	0.0001073	46.0	COG0327@1|root,COG3323@1|root,COG0327@2|Bacteria,COG3323@2|Bacteria,4NF51@976|Bacteroidetes,1FIVF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	NIF3 (NGG1p interacting factor 3)	yqfO	-	-	-	-	-	-	-	-	-	-	-	NIF3
GDHHQS2_k127_3202578_1	1122182.KB903825_gene556	1.71e-16	83.0	2CIYT@1|root,2Z7R8@2|Bacteria,2IDER@201174|Actinobacteria,4DHKK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3202578_0	1121272.KB903251_gene842	1.011e-94	318.0	COG0332@1|root,COG0332@2|Bacteria,2GJSE@201174|Actinobacteria,4DIBB@85008|Micromonosporales	201174|Actinobacteria	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C,Haem_oxygenas_2
GDHHQS2_k127_3205564_1	1206737.BAGF01000023_gene1153	2.889e-89	310.0	COG1940@1|root,COG1940@2|Bacteria,2GPEI@201174|Actinobacteria,4FVZ6@85025|Nocardiaceae	201174|Actinobacteria	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
GDHHQS2_k127_3205564_0	1082931.KKY_1746	1.252e-115	385.0	COG4213@1|root,COG4213@2|Bacteria,1MX63@1224|Proteobacteria,2TQQW@28211|Alphaproteobacteria,3N86S@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
GDHHQS2_k127_3206384_0	1449346.JQMO01000002_gene572	4.691e-46	185.0	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria,2M26X@2063|Kitasatospora	201174|Actinobacteria	T	Osmosensitive K+ channel His kinase sensor domain	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
GDHHQS2_k127_3214901_0	1283299.AUKG01000003_gene217	9.093e-71	261.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4CQYN@84995|Rubrobacteria	84995|Rubrobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
GDHHQS2_k127_3223917_0	1123024.AUII01000009_gene1959	5.268e-149	481.0	COG0596@1|root,COG0596@2|Bacteria,2H4IZ@201174|Actinobacteria,4DYNZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
GDHHQS2_k127_3223917_1	1122138.AQUZ01000025_gene2804	2.008e-55	199.0	COG2114@1|root,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
GDHHQS2_k127_3233375_0	1229780.BN381_130168	3.554e-56	200.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	fpr	GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700	1.18.1.2,1.19.1.1	ko:K00528,ko:K05784	ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220	M00551	R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110,R10159	RC00270,RC01378,RC01450,RC01910	br01602,ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364,iYL1228.KPN_04002	FAD_binding_6,NAD_binding_1
GDHHQS2_k127_3233375_1	1536775.H70737_19940	3.204e-05	55.0	COG2340@1|root,COG2340@2|Bacteria,1UV76@1239|Firmicutes,4I2AC@91061|Bacilli,26YK4@186822|Paenibacillaceae	91061|Bacilli	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
GDHHQS2_k127_3239245_4	33876.JNXY01000010_gene2498	2.01e-13	70.0	COG0842@1|root,COG0842@2|Bacteria,2GP9E@201174|Actinobacteria,4DCXD@85008|Micromonosporales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
GDHHQS2_k127_3239245_0	479434.Sthe_0078	3.926e-172	554.0	COG0477@1|root,COG0477@2|Bacteria,2G89T@200795|Chloroflexi,27Y75@189775|Thermomicrobia	189775|Thermomicrobia	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_3239245_2	326424.FRAAL5169	2.812e-29	124.0	COG1309@1|root,COG1309@2|Bacteria,2I9NV@201174|Actinobacteria,4EW00@85013|Frankiales	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
GDHHQS2_k127_3239245_1	502025.Hoch_5530	2.213e-127	419.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria,2YWN8@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_3239245_3	1146883.BLASA_4234	1.911e-23	102.0	COG3187@1|root,COG3187@2|Bacteria,2HRWJ@201174|Actinobacteria,4EWBE@85013|Frankiales	201174|Actinobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
GDHHQS2_k127_3248582_1	767817.Desgi_4252	9.177e-17	90.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,TetR_N
GDHHQS2_k127_3248582_0	526225.Gobs_1069	7.1e-43	173.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,4ES6Q@85013|Frankiales	201174|Actinobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
GDHHQS2_k127_3253105_0	235985.BBPN01000017_gene5625	4.827e-28	123.0	COG0642@1|root,COG2205@2|Bacteria,2GMB9@201174|Actinobacteria,2NFV4@228398|Streptacidiphilus	201174|Actinobacteria	T	PAS fold	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
GDHHQS2_k127_3253105_1	469383.Cwoe_1101	4.031e-06	55.0	COG4454@1|root,COG4454@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_325471_1	1206732.BAGD01000126_gene5563	2.391e-12	71.0	2EGCD@1|root,33A46@2|Bacteria,2GR1I@201174|Actinobacteria,4G2WY@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
GDHHQS2_k127_325471_0	1229780.BN381_310061	1.308e-104	346.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,3UWC1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0008150,GO:0040007	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
GDHHQS2_k127_3255160_0	1231185.BAMP01000015_gene1754	4.916e-17	93.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,43JT9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS2_k127_3255160_1	416591.Tlet_2006	4.651e-13	76.0	COG1173@1|root,COG1173@2|Bacteria,2GCK9@200918|Thermotogae	200918|Thermotogae	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS2_k127_3255419_1	1458357.BG58_16545	0.0002886	51.0	COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria,1K855@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
GDHHQS2_k127_3255419_0	1128421.JAGA01000003_gene3718	6.814e-219	696.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	msbA	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS2_k127_3256142_0	1146883.BLASA_0355	2.841e-18	95.0	COG0438@1|root,COG0438@2|Bacteria,2I6NY@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_3259830_0	767029.HMPREF9154_1892	1.129e-169	540.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4DN4J@85009|Propionibacteriales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
GDHHQS2_k127_3262512_0	2002.JOEQ01000002_gene4471	1.418e-128	428.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4EG9Z@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS2_k127_3264612_0	266117.Rxyl_0583	1.046e-170	543.0	COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria,4CRM0@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
GDHHQS2_k127_3283848_0	518766.Rmar_2008	1.777e-176	565.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79	ko:K00128,ko:K00135	ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_3283848_2	1133850.SHJG_4465	5.039e-53	195.0	COG0546@1|root,COG0546@2|Bacteria,2GNCU@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,HAD_2,Hydrolase_like
GDHHQS2_k127_3283848_3	67373.JOBF01000003_gene480	2.152e-28	122.0	COG0778@1|root,COG0778@2|Bacteria,2IPN9@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
GDHHQS2_k127_3283848_1	765420.OSCT_1534	1.409e-107	359.0	COG1494@1|root,COG1494@2|Bacteria,2G5XR@200795|Chloroflexi,375AB@32061|Chloroflexia	32061|Chloroflexia	G	TIGRFAM fructose-1,6-bisphosphatase, class II	-	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
GDHHQS2_k127_3283848_4	526225.Gobs_1756	1.463e-12	72.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4ETXI@85013|Frankiales	201174|Actinobacteria	K	periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
GDHHQS2_k127_3286008_0	479431.Namu_1612	1.823e-84	283.0	2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4EVC6@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
GDHHQS2_k127_3286008_3	525368.HMPREF0591_3275	3.871e-12	68.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,Guanylate_cyc,NB-ARC
GDHHQS2_k127_3286008_4	1429046.RR21198_0371	4.917e-12	72.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
GDHHQS2_k127_3286008_1	1500257.JQNM01000019_gene2757	2.987e-48	186.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652,Polyketide_cyc2
GDHHQS2_k127_3286008_2	1032480.MLP_17680	7.747e-34	142.0	COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria,4DQF1@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,TPR_19
GDHHQS2_k127_3292696_1	266117.Rxyl_2052	9.712e-92	304.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CPZQ@84995|Rubrobacteria	84995|Rubrobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
GDHHQS2_k127_3292696_2	1140.Synpcc7942_0808	8.047e-10	68.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1G27M@1117|Cyanobacteria,1H45V@1129|Synechococcus	1117|Cyanobacteria	M	Sucrose-6F-phosphate phosphohydrolase	sps	-	2.4.1.14,3.1.3.24	ko:K00696,ko:K07024	ko00500,ko01100,map00500,map01100	-	R00766,R00805,R06211	RC00005,RC00017,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	iJN678.slr0953	S6PP
GDHHQS2_k127_3292696_0	935848.JAEN01000005_gene3678	5.149e-99	332.0	COG0438@1|root,COG0438@2|Bacteria,1MWVX@1224|Proteobacteria,2U223@28211|Alphaproteobacteria,2PUEG@265|Paracoccus	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	2.4.1.14	ko:K00696	ko00500,ko01100,map00500,map01100	-	R00766	RC00005,RC00028,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP
GDHHQS2_k127_3295892_2	886293.Sinac_2959	1.252e-15	85.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Methyltransf_11,Methyltransf_25
GDHHQS2_k127_3295892_0	1451189.CFAL_08095	3.219e-99	338.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,22K2Q@1653|Corynebacteriaceae	201174|Actinobacteria	T	ATPase related to phosphate starvation-inducible protein PhoH	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
GDHHQS2_k127_3295892_1	258533.BN977_00437	4.276e-46	175.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,2375M@1762|Mycobacteriaceae	201174|Actinobacteria	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
GDHHQS2_k127_3302370_1	580340.Tlie_1193	9.816e-26	119.0	28HF7@1|root,2Z7RC@2|Bacteria,3TAHT@508458|Synergistetes	508458|Synergistetes	C	PFAM Glycine sarcosine betaine reductase component B subunits	-	-	1.21.4.2	ko:K10671	-	-	-	-	ko00000,ko01000	-	-	-	Gly_reductase
GDHHQS2_k127_3302370_0	1324957.K933_04186	1.67e-66	233.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,240TG@183963|Halobacteria	183963|Halobacteria	E	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS2_k127_3305602_2	58344.JOEL01000020_gene5158	0.0001485	45.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria	201174|Actinobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
GDHHQS2_k127_3305602_1	298655.KI912266_gene3244	1.286e-05	54.0	2F6JM@1|root,33Z2I@2|Bacteria,2IRZQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3305602_0	1120956.JHZK01000032_gene126	1.126e-147	480.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,1JQ2P@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_331639_2	439235.Dalk_2943	5.575e-10	66.0	COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	COG0003 Oxyanion-translocating ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
GDHHQS2_k127_331639_3	525909.Afer_0595	1.332e-09	65.0	2ANAN@1|root,31D8Y@2|Bacteria,2HGVW@201174|Actinobacteria,4CNX0@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_331639_0	1229780.BN381_400026	2.454e-183	589.0	COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
GDHHQS2_k127_331639_1	498761.HM1_1427	1.502e-32	137.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia	186801|Clostridia	EG	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS2_k127_3318132_3	383372.Rcas_2920	2.147e-17	84.0	COG0106@1|root,COG0106@2|Bacteria,2G6EC@200795|Chloroflexi,376JE@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
GDHHQS2_k127_3318132_1	246194.CHY_1082	3.762e-23	102.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,42GKT@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM TrpR like protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
GDHHQS2_k127_3318132_0	1379270.AUXF01000002_gene1409	4.596e-65	235.0	COG0040@1|root,COG0040@2|Bacteria,1ZSZP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
GDHHQS2_k127_3318132_2	998088.B565_1880	1.554e-19	93.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1Y459@135624|Aeromonadales	135624|Aeromonadales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
GDHHQS2_k127_3321175_0	479434.Sthe_1230	1.162e-148	478.0	COG2072@1|root,COG2072@2|Bacteria	2|Bacteria	P	N,N-dimethylaniline monooxygenase activity	-	-	-	ko:K07222	-	-	-	-	ko00000	-	-	-	Pyr_redox_3
GDHHQS2_k127_3321175_1	391626.OAN307_c26900	1.531e-34	140.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	MA20_23315	-	-	-	-	-	-	-	-	-	-	-	OsmC
GDHHQS2_k127_3334264_1	592015.HMPREF1705_00473	5.263e-27	115.0	COG1071@1|root,COG1071@2|Bacteria,3TA5N@508458|Synergistetes	508458|Synergistetes	C	E1 component	pdhA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
GDHHQS2_k127_3334264_0	1120983.KB894571_gene2483	1.083e-157	503.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS2_k127_33360_0	33876.JNXY01000022_gene4574	3.01e-68	236.0	COG0377@1|root,COG0377@2|Bacteria,2GJP5@201174|Actinobacteria,4D9WR@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB2	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
GDHHQS2_k127_33360_1	1313172.YM304_35650	3.35e-36	141.0	COG0838@1|root,COG0838@2|Bacteria,2IFDT@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA2	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
GDHHQS2_k127_33360_2	1151126.AQYI01000004_gene1198	1.114e-16	90.0	COG1524@1|root,COG1524@2|Bacteria,2GISU@201174|Actinobacteria,4FMD2@85023|Microbacteriaceae	201174|Actinobacteria	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
GDHHQS2_k127_3336143_1	298655.KI912266_gene3730	5.385e-78	267.0	COG3361@1|root,COG3361@2|Bacteria,2I6N0@201174|Actinobacteria,4EVEC@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
GDHHQS2_k127_3336143_4	1122622.ATWJ01000010_gene1172	9.474e-51	187.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,2IKKU@201174|Actinobacteria,4FHWU@85021|Intrasporangiaceae	201174|Actinobacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1606	PRA-CH
GDHHQS2_k127_3336143_0	525264.HMPREF0305_12340	1.314e-90	307.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,22JQJ@1653|Corynebacteriaceae	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
GDHHQS2_k127_3336143_5	228410.NE0645	7.371e-41	163.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,371YU@32003|Nitrosomonadales	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
GDHHQS2_k127_3336143_3	1236501.BAJU01000011_gene1482	2.043e-65	228.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria,2JPDI@204441|Rhodospirillales	204441|Rhodospirillales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
GDHHQS2_k127_3336143_2	525904.Tter_0659	5.861e-78	271.0	COG0141@1|root,COG0141@2|Bacteria,2NNTS@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
GDHHQS2_k127_3345851_3	1122604.JONR01000020_gene456	5.061e-39	149.0	COG0520@1|root,COG0520@2|Bacteria,1PJFE@1224|Proteobacteria,1RRJK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Selenocysteine lyase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
GDHHQS2_k127_3345851_0	1120949.KB903294_gene3619	2.042e-223	699.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria,4DBN0@85008|Micromonosporales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
GDHHQS2_k127_3345851_1	266117.Rxyl_2557	2.792e-140	456.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria,4CPP8@84995|Rubrobacteria	84995|Rubrobacteria	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
GDHHQS2_k127_3345851_2	926560.KE387023_gene1512	1.12e-53	194.0	COG2323@1|root,COG2323@2|Bacteria,1WMG8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
GDHHQS2_k127_3345851_7	1463825.JNXC01000023_gene4919	1.547e-07	60.0	2C9IE@1|root,32VXA@2|Bacteria,2IK2S@201174|Actinobacteria,4E3DF@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
GDHHQS2_k127_3345851_4	1246448.ANAZ01000061_gene5583	2.167e-37	145.0	COG0251@1|root,COG0251@2|Bacteria,2IHXH@201174|Actinobacteria,4EQGQ@85012|Streptosporangiales	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
GDHHQS2_k127_3346712_0	1313172.YM304_29160	1.735e-125	417.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4CP57@84992|Acidimicrobiia	201174|Actinobacteria	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.21	ko:K02028,ko:K09972,ko:K10041	ko02010,map02010	M00228,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
GDHHQS2_k127_3346712_1	1313172.YM304_29150	1.338e-84	285.0	COG0765@1|root,COG0765@2|Bacteria	2|Bacteria	P	amino acid transport	-	-	-	ko:K02029,ko:K09970,ko:K09971	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
GDHHQS2_k127_3350424_1	1122138.AQUZ01000012_gene6041	6.484e-57	208.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3350424_0	1121877.JQKF01000009_gene576	3.247e-107	359.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
GDHHQS2_k127_3350424_2	1121877.JQKF01000009_gene575	6.367e-29	119.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CMPP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
GDHHQS2_k127_3368223_1	644282.Deba_1107	1.611e-26	114.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
GDHHQS2_k127_3368223_0	1048339.KB913029_gene3335	4.491e-79	283.0	COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,4ES7K@85013|Frankiales	201174|Actinobacteria	L	impB/mucB/samB family	dinB_2	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
GDHHQS2_k127_3368223_2	345341.KUTG_05981	1.176e-06	56.0	COG4544@1|root,COG4544@2|Bacteria,2IIXE@201174|Actinobacteria,4E4BH@85010|Pseudonocardiales	201174|Actinobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3370614_0	28444.JODQ01000009_gene3881	1.801e-116	381.0	COG2216@1|root,COG2216@2|Bacteria,2GIWT@201174|Actinobacteria,4EFS6@85012|Streptosporangiales	201174|Actinobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
GDHHQS2_k127_3370614_1	1205680.CAKO01000040_gene1138	6.889e-38	154.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2TSQ7@28211|Alphaproteobacteria,2JSFW@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
GDHHQS2_k127_3374112_0	1043493.BBLU01000021_gene637	1.492e-136	451.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria	201174|Actinobacteria	D	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
GDHHQS2_k127_3376485_0	134676.ACPL_5074	3.374e-40	153.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4DE4E@85008|Micromonosporales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
GDHHQS2_k127_3376485_1	134676.ACPL_5078	1.987e-32	134.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4DAQQ@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
GDHHQS2_k127_3376485_2	391009.Tmel_0560	9.246e-15	74.0	COG4608@1|root,COG4608@2|Bacteria,2GCGD@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS2_k127_3376656_1	1042375.AFPL01000055_gene2291	1.586e-46	172.0	COG2151@1|root,COG2151@2|Bacteria,1RF3S@1224|Proteobacteria,1S4FY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	phenylacetate-CoA oxygenase, PaaJ subunit	paaD	GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	iECSE_1348.ECSE_1476	FeS_assembly_P
GDHHQS2_k127_3376656_0	1464048.JNZS01000013_gene3177	4.508e-117	390.0	COG1018@1|root,COG1018@2|Bacteria,2GKGS@201174|Actinobacteria,4D9J2@85008|Micromonosporales	201174|Actinobacteria	C	Phenylacetate-CoA oxygenase reductase, PaaK subunit	paaK	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,FA_desaturase,Fer2,NAD_binding_1
GDHHQS2_k127_3380569_1	1120936.KB907217_gene3513	8.884e-39	149.0	COG2124@1|root,COG2124@2|Bacteria,2GKKN@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome P450	-	-	1.14.15.13	ko:K17474,ko:K21034	-	-	-	-	ko00000,ko00199,ko01000	-	-	-	Flavodoxin_1,Pyr_redox_2,p450
GDHHQS2_k127_3380569_0	1313172.YM304_01580	0.0	1017.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2GIVI@201174|Actinobacteria	201174|Actinobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
GDHHQS2_k127_3391210_1	1173024.KI912148_gene2730	1.749e-11	73.0	COG5563@1|root,COG5563@2|Bacteria,1GASM@1117|Cyanobacteria	1117|Cyanobacteria	S	Extracellular repeat protein, HAF family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3466
GDHHQS2_k127_3391210_2	1219035.NT2_08_01360	0.0004395	45.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales	204457|Sphingomonadales	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
GDHHQS2_k127_3391210_0	1123023.JIAI01000001_gene6484	1.457e-84	285.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DZQU@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
GDHHQS2_k127_3393248_0	426355.Mrad2831_0599	6.636e-25	108.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,1JUHB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM NUDIX hydrolase	MA20_44635	-	-	-	-	-	-	-	-	-	-	-	NUDIX
GDHHQS2_k127_3393248_2	1112212.JH584235_gene2800	1.985e-05	54.0	COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2UFVP@28211|Alphaproteobacteria,2K4QR@204457|Sphingomonadales	204457|Sphingomonadales	S	rRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
GDHHQS2_k127_3393248_1	1089548.KI783301_gene1207	1.282e-20	93.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,4HA3U@91061|Bacilli	91061|Bacilli	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
GDHHQS2_k127_3398228_0	67332.FM21_13615	1.714e-178	578.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria	201174|Actinobacteria	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
GDHHQS2_k127_3398228_4	1348663.KCH_27120	1.855e-23	108.0	COG1595@1|root,COG1595@2|Bacteria,2GMPC@201174|Actinobacteria,2M2R5@2063|Kitasatospora	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_3398228_1	383372.Rcas_1454	5.711e-105	353.0	COG0834@1|root,COG0834@2|Bacteria,2G7RH@200795|Chloroflexi,376Y9@32061|Chloroflexia	32061|Chloroflexia	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
GDHHQS2_k127_3398228_2	1121033.AUCF01000001_gene1948	9.325e-70	250.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,2TR7G@28211|Alphaproteobacteria,2JQ13@204441|Rhodospirillales	204441|Rhodospirillales	E	acid transport system permease	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
GDHHQS2_k127_3398228_3	324602.Caur_3239	1.612e-47	186.0	COG0765@1|root,COG0765@2|Bacteria,2G845@200795|Chloroflexi,376Y4@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
GDHHQS2_k127_3403046_0	756272.Plabr_1294	6.457e-85	295.0	COG1611@1|root,COG1611@2|Bacteria,2IXIR@203682|Planctomycetes	203682|Planctomycetes	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
GDHHQS2_k127_3403046_1	292415.Tbd_0824	8.654e-09	67.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
GDHHQS2_k127_3413314_1	1968.JOEV01000025_gene5327	3.269e-44	172.0	COG2510@1|root,COG2510@2|Bacteria,2I3F3@201174|Actinobacteria	201174|Actinobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS2_k127_3413314_0	1229780.BN381_310071	8.391e-76	263.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,3UWNK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
GDHHQS2_k127_3413314_2	1229780.BN381_310072	1.25e-27	119.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,3UWMR@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
GDHHQS2_k127_3414886_0	525904.Tter_0358	2.217e-44	173.0	COG3266@1|root,COG4719@1|root,COG3266@2|Bacteria,COG4719@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF11,Pkinase
GDHHQS2_k127_3417734_0	926550.CLDAP_00080	4.344e-86	294.0	COG0520@1|root,COG0520@2|Bacteria,2G5W7@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
GDHHQS2_k127_3417734_1	994479.GL877879_gene5574	1.75e-75	267.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria,4DY5S@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM YibE F-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
GDHHQS2_k127_3434076_3	1160137.KB907307_gene3308	2.812e-36	143.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4FXI6@85025|Nocardiaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
GDHHQS2_k127_3434076_4	671143.DAMO_2813	9.584e-35	138.0	COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria	2|Bacteria	F	Cytidylate kinase-like family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
GDHHQS2_k127_3434076_0	321955.AAGP01000037_gene2515	1.013e-47	175.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4F8TS@85019|Brevibacteriaceae	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
GDHHQS2_k127_3434076_1	1146883.BLASA_2622	6.298e-46	171.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4ESIT@85013|Frankiales	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
GDHHQS2_k127_3434076_2	1408437.JNJN01000004_gene2003	9.457e-39	152.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,25WMX@186806|Eubacteriaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
GDHHQS2_k127_3434076_5	1064535.MELS_1335	5.943e-12	71.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,4H40G@909932|Negativicutes	909932|Negativicutes	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
GDHHQS2_k127_3445707_0	1229780.BN381_100172	3.689e-264	837.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,3UWEZ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
GDHHQS2_k127_3447393_0	2074.JNYD01000004_gene4948	3.516e-100	334.0	COG1653@1|root,COG1653@2|Bacteria,2IDWS@201174|Actinobacteria,4E16T@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
GDHHQS2_k127_3464773_1	368407.Memar_1229	2.818e-12	69.0	COG2361@1|root,arCOG05024@2157|Archaea	2157|Archaea	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86
GDHHQS2_k127_3464773_0	1122622.ATWJ01000010_gene1297	1.781e-103	346.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
GDHHQS2_k127_3474167_0	1463885.KL578502_gene6536	5.844e-118	391.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	fbiC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
GDHHQS2_k127_3474167_1	1429046.RR21198_3218	5.93e-47	173.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria,4FUFU@85025|Nocardiaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
GDHHQS2_k127_3480104_0	644966.Tmar_0757	2.11e-128	418.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3WCFT@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
GDHHQS2_k127_3509205_0	396014.BF93_15880	1.118e-78	268.0	COG1878@1|root,COG1878@2|Bacteria,2I66K@201174|Actinobacteria	201174|Actinobacteria	S	PFAM cyclase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
GDHHQS2_k127_3509205_1	1449976.KALB_7031	2.299e-55	200.0	COG1120@1|root,COG1120@2|Bacteria,2IA4F@201174|Actinobacteria,4E0AK@85010|Pseudonocardiales	201174|Actinobacteria	HP	ABC-type cobalamin Fe3 -siderophore transport system, ATPase component	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
GDHHQS2_k127_3515994_0	1449355.JQNR01000005_gene5020	2.08e-68	244.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria	201174|Actinobacteria	C	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_3521460_1	345341.KUTG_01132	7.851e-19	94.0	COG1309@1|root,COG1309@2|Bacteria,2GX8K@201174|Actinobacteria,4E2SD@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
GDHHQS2_k127_3521460_0	1121920.AUAU01000018_gene1806	1.329e-86	294.0	COG0332@1|root,COG0332@2|Bacteria,3Y2Z5@57723|Acidobacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180,2.3.1.262	ko:K00648,ko:K18003	ko00061,ko00405,ko01100,ko01130,ko01212,ko02024,ko02025,map00061,map00405,map01100,map01130,map01212,map02024,map02025	M00082,M00083	R10707,R11586,R11587,R11588	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
GDHHQS2_k127_3557544_0	1229780.BN381_250103	1.261e-52	191.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,3UWYQ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Xaa-Pro aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
GDHHQS2_k127_3557544_1	502025.Hoch_4164	3.197e-34	141.0	COG3021@1|root,COG3021@2|Bacteria,1MWFK@1224|Proteobacteria,42QIQ@68525|delta/epsilon subdivisions,2WM7F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
GDHHQS2_k127_3565861_1	935565.JAEM01000031_gene2647	3.624e-10	63.0	COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,2PXST@265|Paracoccus	28211|Alphaproteobacteria	S	CsbD-like	csbD	-	-	-	-	-	-	-	-	-	-	-	CsbD
GDHHQS2_k127_3565861_0	106370.Francci3_3799	5.181e-34	147.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4ES9T@85013|Frankiales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
GDHHQS2_k127_3580520_2	410358.Mlab_1126	8.876e-08	63.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,2N9N5@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
GDHHQS2_k127_3580520_0	1382356.JQMP01000003_gene2429	4.027e-185	600.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi,27XJI@189775|Thermomicrobia	189775|Thermomicrobia	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
GDHHQS2_k127_3580520_1	390989.JOEG01000012_gene3433	1.328e-172	551.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4DBIY@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
GDHHQS2_k127_358173_1	1397528.Q671_15075	6.682e-59	212.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria	1224|Proteobacteria	E	Von willebrand factor, type a	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
GDHHQS2_k127_358173_0	644283.Micau_2889	1.524e-81	284.0	COG1801@1|root,COG1801@2|Bacteria,2HU1R@201174|Actinobacteria,4DADR@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
GDHHQS2_k127_358173_2	321327.CYA_0968	3.709e-55	197.0	COG2947@1|root,COG2947@2|Bacteria,1G5R2@1117|Cyanobacteria,1H08Y@1129|Synechococcus	1117|Cyanobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
GDHHQS2_k127_358173_3	1193181.BN10_690004	1.232e-49	181.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FFNS@85021|Intrasporangiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_358564_0	266117.Rxyl_1305	2.555e-97	333.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4CPUG@84995|Rubrobacteria	84995|Rubrobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
GDHHQS2_k127_358564_1	404380.Gbem_1995	5.709e-16	85.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,43TCH@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
GDHHQS2_k127_3595533_0	247156.NFA_35190	9.607e-122	394.0	COG1788@1|root,COG1788@2|Bacteria,2I9F6@201174|Actinobacteria,4FZB8@85025|Nocardiaceae	201174|Actinobacteria	I	Coenzyme A transferase	catI	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
GDHHQS2_k127_3595533_1	42256.RradSPS_1068	8.996e-104	348.0	COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,4CPVM@84995|Rubrobacteria	84995|Rubrobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
GDHHQS2_k127_3595533_2	263358.VAB18032_19750	5.119e-83	283.0	COG1414@1|root,COG1414@2|Bacteria,2GNHA@201174|Actinobacteria,4D9QJ@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	pcaR	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
GDHHQS2_k127_3596943_1	96561.Dole_1727	1.013e-46	177.0	COG0484@1|root,COG0705@1|root,COG0484@2|Bacteria,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2MI6P@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	DnaJ_C,Rhomboid
GDHHQS2_k127_3596943_0	223184.AS25_13330	2.397e-62	222.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,1W8NS@1268|Micrococcaceae	201174|Actinobacteria	J	FtsJ-like methyltransferase	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
GDHHQS2_k127_3612815_1	110319.CF8_0629	0.0006689	46.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4DP1T@85009|Propionibacteriales	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
GDHHQS2_k127_3612815_0	1313172.YM304_28820	2.249e-35	145.0	COG0741@1|root,COG0741@2|Bacteria,2IF18@201174|Actinobacteria	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
GDHHQS2_k127_3616396_1	1158612.I580_02023	1.634e-39	155.0	COG0580@1|root,COG0580@2|Bacteria,1UZX3@1239|Firmicutes,4HA8I@91061|Bacilli,4B1P2@81852|Enterococcaceae	91061|Bacilli	U	Belongs to the MIP aquaporin (TC 1.A.8) family	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
GDHHQS2_k127_3616396_2	1370125.AUWT01000034_gene1330	4.945e-06	58.0	COG2105@1|root,COG4195@1|root,COG2105@2|Bacteria,COG4195@2|Bacteria,2GU51@201174|Actinobacteria,235BA@1762|Mycobacteriaceae	201174|Actinobacteria	C	Replication protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
GDHHQS2_k127_3616396_0	1122915.AUGY01000001_gene7025	1.049e-60	224.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,4H9KQ@91061|Bacilli,26SMA@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004425,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
GDHHQS2_k127_3616944_0	1449976.KALB_7262	7.087e-266	842.0	COG0466@1|root,COG0466@2|Bacteria,2GK9D@201174|Actinobacteria,4DYVW@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
GDHHQS2_k127_3616944_1	351607.Acel_2115	7.446e-167	529.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4ERTY@85013|Frankiales	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
GDHHQS2_k127_3624715_0	1380390.JIAT01000010_gene4575	4.315e-108	366.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria	84995|Rubrobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
GDHHQS2_k127_3624715_1	247156.NFA_37450	1.467e-27	124.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4FYAC@85025|Nocardiaceae	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
GDHHQS2_k127_3632485_0	351607.Acel_1340	2.53e-67	243.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4ERCU@85013|Frankiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
GDHHQS2_k127_3632485_1	1120950.KB892708_gene4277	5.609e-16	80.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4DP94@85009|Propionibacteriales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
GDHHQS2_k127_3637491_0	1206744.BAGL01000055_gene1468	3.263e-59	218.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4FWK7@85025|Nocardiaceae	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
GDHHQS2_k127_3646206_1	67352.JODS01000032_gene695	1.537e-14	78.0	COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria	201174|Actinobacteria	S	BioY protein	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
GDHHQS2_k127_3646206_0	1122622.ATWJ01000007_gene1536	9.238e-45	177.0	COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4FFGH@85021|Intrasporangiaceae	201174|Actinobacteria	T	Belongs to the peptidase S16 family	ylbL	-	-	ko:K07177	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	Lon_C,PDZ_2
GDHHQS2_k127_3671402_2	926554.KI912653_gene4147	5.672e-36	142.0	arCOG10517@1|root,31Y5Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3671402_1	1380393.JHVP01000005_gene3585	4.988e-58	216.0	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4EWT7@85013|Frankiales	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
GDHHQS2_k127_3671402_0	710696.Intca_3443	2.012e-122	405.0	COG0189@1|root,COG0189@2|Bacteria,2I5WV@201174|Actinobacteria,4FF3F@85021|Intrasporangiaceae	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3694399_1	1449355.JQNR01000003_gene283	3.109e-48	185.0	COG2129@1|root,COG2129@2|Bacteria,2GMTQ@201174|Actinobacteria	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
GDHHQS2_k127_3694399_0	1211815.CBYP010000041_gene2473	2.705e-52	186.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4ERXY@85013|Frankiales	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
GDHHQS2_k127_369605_0	1382306.JNIM01000001_gene1969	2.4e-64	229.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	ogt	-	2.1.1.63,3.2.2.21	ko:K00567,ko:K13529,ko:K15051	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AraC_binding,DNA_binding_1,Endonuclea_NS_2,HTH_18
GDHHQS2_k127_369605_1	1172180.KB911794_gene3456	1.995e-30	128.0	COG1595@1|root,COG1595@2|Bacteria,2HGII@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_3702032_1	469383.Cwoe_2709	1.932e-51	184.0	COG1595@1|root,COG3631@1|root,COG1595@2|Bacteria,COG3631@2|Bacteria,2GMRK@201174|Actinobacteria,4CRR4@84995|Rubrobacteria	201174|Actinobacteria	K	Sigma-70 region 2	sigG	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	NTF2,Sigma70_r2,Sigma70_r4_2,SnoaL_2
GDHHQS2_k127_3702032_0	469371.Tbis_3262	6.571e-52	188.0	COG0662@1|root,COG0662@2|Bacteria,2IMPE@201174|Actinobacteria	201174|Actinobacteria	G	COG0662 Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_3702032_2	756067.MicvaDRAFT_3901	1.031e-18	90.0	COG1308@1|root,COG1308@2|Bacteria,1G83N@1117|Cyanobacteria,1HC9J@1150|Oscillatoriales	1117|Cyanobacteria	K	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
GDHHQS2_k127_3702032_3	237368.SCABRO_00812	1.147e-05	49.0	COG1872@1|root,COG1872@2|Bacteria,2J1ES@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
GDHHQS2_k127_3702837_1	446462.Amir_1571	1.506e-05	47.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4DY4T@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA primase, small subunit	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
GDHHQS2_k127_3702837_0	1394178.AWOO02000027_gene5302	7.769e-103	345.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4EHHS@85012|Streptosporangiales	201174|Actinobacteria	C	2-oxoglutarate dehydrogenase C-terminal	kgd	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
GDHHQS2_k127_3708695_0	1128421.JAGA01000002_gene820	0.0001483	48.0	COG0438@1|root,COG0438@2|Bacteria,2NP3N@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	MA20_17390	-	-	ko:K00713,ko:K06338	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_3716311_0	880072.Desac_0006	1.452e-135	445.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2MRAX@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
GDHHQS2_k127_3716311_3	1205680.CAKO01000040_gene862	6.15e-42	157.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
GDHHQS2_k127_3716311_2	1896.JOAU01000029_gene5498	1.032e-88	323.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
GDHHQS2_k127_3716311_1	1121481.AUAS01000006_gene750	6.709e-116	379.0	COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,47Q3U@768503|Cytophagia	976|Bacteroidetes	IQ	KR domain	-	-	1.1.1.53	ko:K00038	ko00140,ko01100,map00140,map01100	-	R04831,R04834,R04844,R04847	RC00139,RC01219,RC01220	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
GDHHQS2_k127_3724736_1	471853.Bcav_2118	2.058e-13	75.0	COG4758@1|root,COG4758@2|Bacteria	2|Bacteria	KT	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154
GDHHQS2_k127_3724736_0	1380358.JADJ01000013_gene3430	6.987e-18	94.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Usp
GDHHQS2_k127_3735201_0	1211815.CBYP010000021_gene3284	4.083e-29	127.0	COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
GDHHQS2_k127_3735201_1	105425.BBPL01000025_gene373	1.489e-05	55.0	COG0457@1|root,COG1672@1|root,COG3629@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,COG3629@2|Bacteria,2H1NS@201174|Actinobacteria	201174|Actinobacteria	K	DNA-binding transcriptional activator of the SARP family	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Glyco_hydro_16,NB-ARC,TPR_12,TPR_7,Trans_reg_C
GDHHQS2_k127_3740178_0	765420.OSCT_1185	3.649e-176	567.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2G64C@200795|Chloroflexi,376K3@32061|Chloroflexia	32061|Chloroflexia	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
GDHHQS2_k127_3740594_1	390989.JOEG01000006_gene798	3.939e-06	56.0	COG5662@1|root,COG5662@2|Bacteria,2GNCC@201174|Actinobacteria,4D9EP@85008|Micromonosporales	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
GDHHQS2_k127_3740594_0	1089545.KB913037_gene5529	7.778e-50	182.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4DYCJ@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_3752362_0	1365176.N186_05410	6.851e-52	202.0	COG1574@1|root,arCOG00691@2157|Archaea,2XPRG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Amidohydrolase 3	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
GDHHQS2_k127_3752362_1	1541065.JRFE01000022_gene4069	6.682e-28	116.0	COG0483@1|root,COG0483@2|Bacteria,1G0GD@1117|Cyanobacteria,3VHUH@52604|Pleurocapsales	1117|Cyanobacteria	G	PFAM Inositol monophosphatase family	suhB	GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
GDHHQS2_k127_3769363_2	653733.Selin_0202	9.415e-07	57.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	uspE	-	-	-	-	-	-	-	-	-	-	-	Usp
GDHHQS2_k127_3769363_0	1120950.KB892743_gene3110	4.824e-68	238.0	COG2360@1|root,COG2360@2|Bacteria,2IFT7@201174|Actinobacteria,4DQD7@85009|Propionibacteriales	201174|Actinobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
GDHHQS2_k127_3769363_1	1380394.JADL01000004_gene5852	1.994e-52	190.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,2JPAH@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
GDHHQS2_k127_379024_0	1122138.AQUZ01000019_gene8163	1.875e-80	272.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DQD4@85009|Propionibacteriales	201174|Actinobacteria	E	Amino acid amide ABC transporter ATP-binding protein 2, HAAT family	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS2_k127_379024_1	1121289.JHVL01000005_gene1013	1.736e-28	124.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EAC@31979|Clostridiaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
GDHHQS2_k127_379173_3	1386089.N865_15920	1.316e-25	113.0	2EC8S@1|root,33677@2|Bacteria,2GUT2@201174|Actinobacteria,4FI39@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_379173_1	1122138.AQUZ01000003_gene462	3.07e-33	133.0	COG3832@1|root,COG3832@2|Bacteria,2IG6F@201174|Actinobacteria,4DR5W@85009|Propionibacteriales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_379173_2	981384.AEYW01000006_gene2356	1.103e-26	112.0	COG0640@1|root,COG0640@2|Bacteria,1RJ39@1224|Proteobacteria,2UA6C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
GDHHQS2_k127_379173_0	857087.Metme_2224	4.787e-247	776.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1XDIT@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
GDHHQS2_k127_3792245_1	1313172.YM304_28400	1.79e-05	53.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
GDHHQS2_k127_3805483_0	1380347.JNII01000011_gene1034	6.392e-80	278.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
GDHHQS2_k127_3805483_1	479433.Caci_7040	1.56e-35	143.0	COG3793@1|root,COG3793@2|Bacteria,2GK3X@201174|Actinobacteria	201174|Actinobacteria	P	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
GDHHQS2_k127_3810464_0	266940.Krad_3213	1.187e-76	266.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
GDHHQS2_k127_3810464_5	525909.Afer_0682	1.468e-06	55.0	2ERJT@1|root,33J59@2|Bacteria,2HGGQ@201174|Actinobacteria,4CNDW@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
GDHHQS2_k127_3810464_4	1122994.AUFR01000015_gene1824	3.184e-23	108.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4DPQ2@85009|Propionibacteriales	201174|Actinobacteria	K	helix_turn_helix, mercury resistance	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
GDHHQS2_k127_3810464_2	1463855.JOHV01000002_gene2453	1.678e-45	189.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
GDHHQS2_k127_3810464_3	710111.FraQA3DRAFT_2868	4.149e-41	167.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,4ERVY@85013|Frankiales	201174|Actinobacteria	J	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
GDHHQS2_k127_3810464_1	1120950.KB892707_gene4879	2.432e-64	225.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DNSG@85009|Propionibacteriales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
GDHHQS2_k127_3814192_0	595460.RRSWK_03756	3.6e-81	276.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
GDHHQS2_k127_3814192_1	322710.Avin_51110	3.426e-68	243.0	COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,1RQ6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Formate nitrite	-	-	-	ko:K06212	-	-	-	-	ko00000,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	Form_Nir_trans
GDHHQS2_k127_3839748_1	269799.Gmet_0394	6.716e-81	289.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2WJ9Y@28221|Deltaproteobacteria,43TUI@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
GDHHQS2_k127_3839748_0	298655.KI912266_gene5297	2.279e-114	380.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4ERX9@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS2_k127_3839748_4	1380356.JNIK01000001_gene2272	1.135e-07	56.0	2DRKZ@1|root,33C8D@2|Bacteria,2I1C7@201174|Actinobacteria,4ETMF@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3839748_2	383372.Rcas_1143	1.409e-35	141.0	2ECZ8@1|root,336W9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3839748_3	266117.Rxyl_0417	1.069e-11	74.0	COG4114@1|root,COG4114@2|Bacteria	2|Bacteria	HP	ferric iron reductase	-	-	-	-	-	-	-	-	-	-	-	-	FhuF,FhuF_C
GDHHQS2_k127_3840179_0	479434.Sthe_2607	8.652e-110	374.0	COG1032@1|root,COG1032@2|Bacteria,2G7MA@200795|Chloroflexi,27Y05@189775|Thermomicrobia	189775|Thermomicrobia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
GDHHQS2_k127_3840179_1	1242864.D187_003377	7.596e-46	178.0	COG2267@1|root,COG2267@2|Bacteria,1R9DT@1224|Proteobacteria	1224|Proteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
GDHHQS2_k127_3846952_1	1121423.JONT01000004_gene1717	1.633e-21	98.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,261U2@186807|Peptococcaceae	186801|Clostridia	P	PFAM ABC transporter	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
GDHHQS2_k127_3846952_2	1132509.C447_10830	2.576e-11	74.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type Cobalt transport system, permease	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
GDHHQS2_k127_3846952_0	246196.MSMEI_6692	2.024e-149	482.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,232XE@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
GDHHQS2_k127_3856555_0	945713.IALB_1869	5.439e-157	509.0	COG1009@1|root,COG1009@2|Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
GDHHQS2_k127_3856555_1	1121877.JQKF01000009_gene573	5.721e-29	126.0	COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4CN4N@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
GDHHQS2_k127_3856555_2	1210046.B277_04582	7.214e-28	121.0	COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4FFRB@85021|Intrasporangiaceae	201174|Actinobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
GDHHQS2_k127_3856555_3	1313172.YM304_04140	2.609e-24	105.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CMPP@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
GDHHQS2_k127_3859081_2	1132441.KI519455_gene3925	4.342e-12	71.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,1W7R4@1268|Micrococcaceae	201174|Actinobacteria	T	response regulator	phoP	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_3859081_0	1158050.KB895455_gene1716	3.687e-59	215.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,1W904@1268|Micrococcaceae	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
GDHHQS2_k127_3859081_1	1449357.JQLK01000001_gene1011	2.754e-21	102.0	COG0204@1|root,COG0204@2|Bacteria,1WJXG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
GDHHQS2_k127_3860913_0	382464.ABSI01000013_gene1532	1.083e-61	242.0	COG3629@1|root,COG3629@2|Bacteria	2|Bacteria	K	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,NACHT,NB-ARC,WD40
GDHHQS2_k127_3860913_1	287986.DV20_32760	3.853e-05	57.0	COG3903@1|root,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4E1A7@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator, SARP family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,NB-ARC,TPR_12
GDHHQS2_k127_3865488_0	309801.trd_A0570	6.414e-30	125.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G8NJ@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
GDHHQS2_k127_3865488_1	196162.Noca_2942	2.655e-29	122.0	COG4585@1|root,COG4585@2|Bacteria,2HESU@201174|Actinobacteria,4DVT5@85009|Propionibacteriales	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
GDHHQS2_k127_3865488_2	639030.JHVA01000001_gene3024	2.33e-15	77.0	COG2197@1|root,COG2197@2|Bacteria,3Y4G0@57723|Acidobacteria,2JJ28@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_3889266_0	293826.Amet_2457	7.86e-34	145.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EAC@31979|Clostridiaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
GDHHQS2_k127_3889266_2	1236902.ANAS01000034_gene1067	9.197e-05	52.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4EI14@85012|Streptosporangiales	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	yvhJ	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
GDHHQS2_k127_3889266_1	1035308.AQYY01000001_gene1750	3.052e-13	73.0	2CUM0@1|root,32SVJ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3263)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3263
GDHHQS2_k127_3892138_3	1122138.AQUZ01000001_gene1847	1.987e-22	98.0	COG2146@1|root,COG2220@1|root,COG2146@2|Bacteria,COG2220@2|Bacteria,2GP4N@201174|Actinobacteria,4DUME@85009|Propionibacteriales	201174|Actinobacteria	P	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3,Rieske
GDHHQS2_k127_3892138_1	1313172.YM304_08090	5.827e-62	215.0	COG0048@1|root,COG0048@2|Bacteria,2IHUF@201174|Actinobacteria,4CN6J@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
GDHHQS2_k127_3892138_2	1229780.BN381_180002	1.844e-61	214.0	COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,3UWK1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
GDHHQS2_k127_3892138_0	639282.DEFDS_1775	4.693e-301	937.0	COG0480@1|root,COG0480@2|Bacteria,2GFAG@200930|Deferribacteres	200930|Deferribacteres	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
GDHHQS2_k127_3892138_4	397290.C810_03373	1.141e-19	89.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,27I75@186928|unclassified Lachnospiraceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
GDHHQS2_k127_3896585_0	471852.Tcur_0550	1.273e-96	325.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
GDHHQS2_k127_3896585_1	1120950.KB892742_gene3009	7.318e-29	118.0	COG0412@1|root,COG0412@2|Bacteria,2GJMH@201174|Actinobacteria,4DQY9@85009|Propionibacteriales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
GDHHQS2_k127_3896696_1	1278073.MYSTI_07289	4.329e-21	96.0	COG4191@1|root,COG4191@2|Bacteria,1P2F7@1224|Proteobacteria,42PRA@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_9,cNMP_binding,dCache_1
GDHHQS2_k127_3896696_0	1403819.BATR01000022_gene806	4.001e-140	475.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
GDHHQS2_k127_3900972_1	1211817.CCAT010000070_gene1262	9.751e-14	73.0	COG2116@1|root,COG2116@2|Bacteria,1TRTT@1239|Firmicutes,24BU5@186801|Clostridia,36F4N@31979|Clostridiaceae	186801|Clostridia	P	Formate nitrite	fnt	-	-	ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2	-	-	Form_Nir_trans
GDHHQS2_k127_3900972_0	106370.Francci3_3546	4.992e-133	426.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4ERMR@85013|Frankiales	201174|Actinobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
GDHHQS2_k127_390178_0	926550.CLDAP_19470	8.633e-10	65.0	COG0457@1|root,COG3629@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3903@2|Bacteria,2G7SC@200795|Chloroflexi	200795|Chloroflexi	K	intracellular signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
GDHHQS2_k127_390178_1	522306.CAP2UW1_0032	5.83e-06	57.0	2D125@1|root,32T9R@2|Bacteria,1N30F@1224|Proteobacteria,2VX2H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_3904258_2	479434.Sthe_1252	3.291e-25	106.0	COG0126@1|root,COG0126@2|Bacteria,2G5UE@200795|Chloroflexi,27XWV@189775|Thermomicrobia	189775|Thermomicrobia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
GDHHQS2_k127_3904258_1	1229780.BN381_80403	3.699e-92	309.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,3UWH0@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
GDHHQS2_k127_3904258_0	575540.Isop_1724	1.772e-97	329.0	COG0588@1|root,COG0588@2|Bacteria	2|Bacteria	G	phosphoglycerate mutase activity	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
GDHHQS2_k127_3904258_3	1229780.BN381_80404	7.364e-16	80.0	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria,3UWW8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Preprotein translocase SecG subunit	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
GDHHQS2_k127_3910840_2	1157637.KB892124_gene795	0.0005505	50.0	COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria	201174|Actinobacteria	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
GDHHQS2_k127_3910840_1	309801.trd_1211	1.244e-26	120.0	COG1975@1|root,COG1975@2|Bacteria,2G6Z8@200795|Chloroflexi,27YDJ@189775|Thermomicrobia	189775|Thermomicrobia	O	XdhC and CoxI family	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_CoxI
GDHHQS2_k127_3910840_0	518766.Rmar_2376	3.584e-70	250.0	COG3552@1|root,COG3552@2|Bacteria,4NKWF@976|Bacteroidetes	976|Bacteroidetes	S	Protein containing von Willebrand factor type A (vWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
GDHHQS2_k127_3951938_2	32051.SynWH7803_0102	1.832e-07	57.0	COG1209@1|root,COG1209@2|Bacteria,1G091@1117|Cyanobacteria,1GYI5@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
GDHHQS2_k127_3951938_0	316058.RPB_1562	2.393e-122	403.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2TT5T@28211|Alphaproteobacteria,3JRQ2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
GDHHQS2_k127_3951938_1	1229780.BN381_290020	1.593e-57	207.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	wecE	-	2.6.1.59	ko:K02805	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	DegT_DnrJ_EryC1
GDHHQS2_k127_39537_3	311402.Avi_5349	1.029e-40	152.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,4B73U@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	dppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363	-	ko:K02035,ko:K12368	ko02010,ko02024,ko02030,map02010,map02024,map02030	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GDHHQS2_k127_39537_0	311402.Avi_5350	3.829e-139	451.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,4BBR1@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS2_k127_39537_1	311402.Avi_5351	5.642e-131	425.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,4B73C@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
GDHHQS2_k127_39537_2	926569.ANT_01400	1.689e-130	426.0	COG0444@1|root,COG0444@2|Bacteria,2G5PT@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS2_k127_3959423_1	555088.DealDRAFT_1144	3.457e-14	78.0	29Y0M@1|root,30JTI@2|Bacteria,1VEVD@1239|Firmicutes,24R5J@186801|Clostridia	186801|Clostridia	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
GDHHQS2_k127_3959423_0	1048339.KB913029_gene3284	1.797e-43	170.0	COG2206@1|root,COG2206@2|Bacteria,2GJB1@201174|Actinobacteria,4EUK3@85013|Frankiales	201174|Actinobacteria	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
GDHHQS2_k127_3961328_0	397278.JOJN01000002_gene614	7.767e-137	445.0	COG5276@1|root,COG5276@2|Bacteria,2IH2N@201174|Actinobacteria	201174|Actinobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
GDHHQS2_k127_3961328_1	1121380.JNIW01000075_gene718	1.004e-130	424.0	COG0141@1|root,COG0141@2|Bacteria	2|Bacteria	E	histidinol dehydrogenase activity	hisD2	-	1.1.1.308	ko:K15509	-	-	-	-	ko00000,ko01000	-	-	-	Histidinol_dh
GDHHQS2_k127_3964490_1	644548.SCNU_02652	1.613e-22	101.0	COG1309@1|root,COG1309@2|Bacteria,2GP91@201174|Actinobacteria,4GAVW@85026|Gordoniaceae	201174|Actinobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
GDHHQS2_k127_3964490_0	298653.Franean1_0656	2.641e-100	337.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ESAG@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994,ko:K20470	-	-	-	-	ko00000,ko02000	2.A.6.5.6	-	-	MMPL
GDHHQS2_k127_3967162_0	69279.BG36_23405	1.956e-140	457.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,43IUF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acsA1	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
GDHHQS2_k127_3971244_0	468556.AQYG01000048_gene709	7.717e-105	355.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4GCMK@85026|Gordoniaceae	201174|Actinobacteria	L	DNA polymerase alpha chain like domain	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
GDHHQS2_k127_4019114_1	1380370.JIBA01000010_gene2534	7.693e-47	171.0	COG3801@1|root,COG3801@2|Bacteria,2IHXB@201174|Actinobacteria,4FH0M@85021|Intrasporangiaceae	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
GDHHQS2_k127_4019114_0	1120950.KB892770_gene1356	4.354e-72	246.0	COG1917@1|root,COG1917@2|Bacteria,2IIQD@201174|Actinobacteria,4DR5R@85009|Propionibacteriales	201174|Actinobacteria	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_4019114_3	512565.AMIS_40930	8.819e-40	153.0	COG3832@1|root,COG3832@2|Bacteria,2II0Q@201174|Actinobacteria,4DIMU@85008|Micromonosporales	201174|Actinobacteria	S	Activator of Hsp90 ATPase 1 family	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_4019114_2	1380354.JIAN01000005_gene2256	1.795e-40	154.0	COG0640@1|root,COG0640@2|Bacteria,2IQYC@201174|Actinobacteria	201174|Actinobacteria	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GDHHQS2_k127_4019114_4	1128421.JAGA01000003_gene3550	5.34e-26	110.0	COG0277@1|root,COG0277@2|Bacteria,2NQTQ@2323|unclassified Bacteria	2|Bacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
GDHHQS2_k127_4029732_0	525909.Afer_1903	1.486e-63	222.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4CMPF@84992|Acidimicrobiia	84992|Acidimicrobiia	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
GDHHQS2_k127_4029732_2	1382356.JQMP01000003_gene1545	2.733e-22	108.0	KOG2524@1|root,2ZJ84@2|Bacteria,2G826@200795|Chloroflexi,27XIS@189775|Thermomicrobia	189775|Thermomicrobia	S	Potential Queuosine, Q, salvage protein family	-	-	-	-	-	-	-	-	-	-	-	-	Q_salvage
GDHHQS2_k127_4029732_1	1313172.YM304_11220	1.036e-37	149.0	COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria	201174|Actinobacteria	S	basic membrane	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
GDHHQS2_k127_4030912_0	298655.KI912266_gene419	1.244e-32	134.0	COG1028@1|root,COG1028@2|Bacteria,2GMG3@201174|Actinobacteria,4ERGA@85013|Frankiales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
GDHHQS2_k127_4030912_1	1382304.JNIL01000001_gene1710	3.734e-23	105.0	COG1853@1|root,COG1853@2|Bacteria,1V1X6@1239|Firmicutes,4HGJ2@91061|Bacilli,279EA@186823|Alicyclobacillaceae	91061|Bacilli	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
GDHHQS2_k127_4035122_1	1121468.AUBR01000056_gene1488	7.411e-41	156.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,42ENV@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM ABC transporter related	-	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
GDHHQS2_k127_4035122_0	1121468.AUBR01000056_gene1489	2.943e-62	229.0	COG1470@1|root,COG1470@2|Bacteria,1TZ9A@1239|Firmicutes,24C4A@186801|Clostridia,42GG3@68295|Thermoanaerobacterales	186801|Clostridia	S	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
GDHHQS2_k127_4036981_2	1386089.N865_08640	1.58e-34	138.0	COG2334@1|root,COG2334@2|Bacteria,2GQU8@201174|Actinobacteria,4FG7U@85021|Intrasporangiaceae	201174|Actinobacteria	S	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
GDHHQS2_k127_4036981_1	1397278.AYMV01000051_gene2530	1.81e-73	254.0	COG2820@1|root,COG2820@2|Bacteria,2I4KP@201174|Actinobacteria,4FPMP@85023|Microbacteriaceae	201174|Actinobacteria	F	Phosphorylase superfamily	udp	-	2.4.2.1,2.4.2.3	ko:K00757,ko:K03784	ko00230,ko00240,ko00760,ko00983,ko01100,ko01110,map00230,map00240,map00760,map00983,map01100,map01110	-	R01561,R01863,R01876,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08229,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
GDHHQS2_k127_4036981_0	1123322.KB904658_gene1286	1.087e-81	277.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2GNEI@201174|Actinobacteria	201174|Actinobacteria	IQ	Rhamnulose-1-phosphate aldolase alcohol dehydrogenase	srlD	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,adh_short,adh_short_C2
GDHHQS2_k127_4050789_1	1121382.JQKG01000031_gene3673	6.983e-51	186.0	COG2166@1|root,COG2166@2|Bacteria,1WK00@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	SufE protein probably involved in Fe-S center assembly	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
GDHHQS2_k127_4050789_0	33876.JNXY01000025_gene5273	1.657e-66	230.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4D8QA@85008|Micromonosporales	201174|Actinobacteria	P	Sulfurtransferase	sseA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
GDHHQS2_k127_4056710_0	525368.HMPREF0591_3639	3.944e-103	360.0	COG2114@1|root,COG2197@1|root,COG3903@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
GDHHQS2_k127_4056710_1	134676.ACPL_5090	8.615e-26	111.0	28VK2@1|root,2ZHNE@2|Bacteria,2IBCS@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
GDHHQS2_k127_4057166_0	574087.Acear_0856	1.553e-71	259.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WA8B@53433|Halanaerobiales	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
GDHHQS2_k127_4057166_1	67352.JODS01000002_gene1670	8.518e-34	132.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria	201174|Actinobacteria	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
GDHHQS2_k127_4078277_2	1120959.ATXF01000010_gene44	4.271e-16	81.0	COG0477@1|root,COG0477@2|Bacteria,2I2IE@201174|Actinobacteria,4FKC6@85023|Microbacteriaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
GDHHQS2_k127_4078277_0	1313172.YM304_01560	9.755e-241	761.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	MA20_01050	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
GDHHQS2_k127_4078277_1	1313172.YM304_01570	1.699e-81	276.0	COG0402@1|root,COG0402@2|Bacteria,2ISY0@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_4082355_2	67352.JODS01000006_gene6435	1.875e-28	130.0	2BWH2@1|root,2Z89R@2|Bacteria,2GMNW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
GDHHQS2_k127_4082355_1	644283.Micau_6202	1.815e-83	284.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DBPG@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter related	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS2_k127_4082355_0	1075090.GOAMR_33_00710	2.031e-193	610.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4GC5F@85026|Gordoniaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_4083700_2	1194972.MVAC_10122	2.04e-41	162.0	COG1802@1|root,COG1802@2|Bacteria,2GKH7@201174|Actinobacteria,236SS@1762|Mycobacteriaceae	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
GDHHQS2_k127_4083700_1	1146883.BLASA_1457	2.349e-109	368.0	COG0654@1|root,COG0654@2|Bacteria,2GNA8@201174|Actinobacteria,4EUAG@85013|Frankiales	201174|Actinobacteria	C	FAD binding domain	-	-	1.14.13.10	ko:K19189	ko00760,ko01120,map00760,map01120	-	R04130	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,NAD_binding_8
GDHHQS2_k127_4083700_3	388739.RSK20926_20245	2.68e-23	105.0	COG0662@1|root,COG0662@2|Bacteria,1QZPS@1224|Proteobacteria,2TYBR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_4083700_0	234621.RER_33580	3.559e-118	387.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria,4FUIQ@85025|Nocardiaceae	201174|Actinobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
GDHHQS2_k127_4083700_4	263358.VAB18032_15310	7.915e-21	98.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4D8FG@85008|Micromonosporales	201174|Actinobacteria	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
GDHHQS2_k127_4087523_1	690850.Desaf_0472	2.102e-87	297.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2M9FA@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
GDHHQS2_k127_4087523_0	292564.Cyagr_2086	5.58e-135	447.0	COG0138@1|root,COG0138@2|Bacteria,1G10K@1117|Cyanobacteria,22RZ4@167375|Cyanobium	1117|Cyanobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.purH	AICARFT_IMPCHas,MGS
GDHHQS2_k127_4087523_2	562970.Btus_0821	4.303e-49	184.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,4HGY5@91061|Bacilli,278BB@186823|Alicyclobacillaceae	91061|Bacilli	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
GDHHQS2_k127_4092935_1	525909.Afer_0728	2.172e-123	408.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CMRS@84992|Acidimicrobiia	84992|Acidimicrobiia	HP	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,ThiF
GDHHQS2_k127_4092935_5	1009370.ALO_07398	3.882e-16	89.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,4H5G1@909932|Negativicutes	909932|Negativicutes	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
GDHHQS2_k127_4092935_3	1122603.ATVI01000005_gene3858	4.323e-27	125.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,1RYF6@1236|Gammaproteobacteria,1X6VE@135614|Xanthomonadales	135614|Xanthomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
GDHHQS2_k127_4092935_0	1337936.IJ00_06810	7.679e-125	415.0	COG0520@1|root,COG0520@2|Bacteria,1G0VG@1117|Cyanobacteria,1HQI0@1161|Nostocales	1117|Cyanobacteria	E	Aminotransferase class-V	-	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
GDHHQS2_k127_4092935_2	1122609.AUGT01000009_gene3335	1.771e-76	267.0	COG0123@1|root,COG0123@2|Bacteria,2I8UK@201174|Actinobacteria,4DU14@85009|Propionibacteriales	201174|Actinobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
GDHHQS2_k127_4096242_0	522306.CAP2UW1_2212	9.269e-36	151.0	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VMUZ@28216|Betaproteobacteria,1KQTS@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
GDHHQS2_k127_4111587_0	1382356.JQMP01000003_gene1441	3.891e-70	251.0	COG2055@1|root,COG2055@2|Bacteria,2G6M2@200795|Chloroflexi,27Y1Q@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
GDHHQS2_k127_4111587_2	861299.J421_6143	7.944e-22	104.0	COG4032@1|root,COG4032@2|Bacteria	2|Bacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_N
GDHHQS2_k127_4111587_1	1210884.HG799465_gene11490	1.694e-27	122.0	COG0028@1|root,COG0028@2|Bacteria,2J4H0@203682|Planctomycetes	203682|Planctomycetes	EH	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
GDHHQS2_k127_4134894_8	1122138.AQUZ01000016_gene197	1.324e-43	166.0	COG2839@1|root,COG2839@2|Bacteria,2IQDE@201174|Actinobacteria,4DRW6@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
GDHHQS2_k127_4134894_3	204669.Acid345_0985	4.933e-114	374.0	COG0266@1|root,COG0266@2|Bacteria,3Y71J@57723|Acidobacteria,2JKGK@204432|Acidobacteriia	204432|Acidobacteriia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
GDHHQS2_k127_4134894_4	1333998.M2A_2343	2.564e-104	349.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	NADP-dependent oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
GDHHQS2_k127_4134894_7	1192034.CAP_6685	6.278e-59	219.0	COG0477@1|root,COG2814@2|Bacteria,1PFB3@1224|Proteobacteria,42N9W@68525|delta/epsilon subdivisions,2WJW0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_4134894_5	330084.JNYZ01000013_gene5881	1.747e-98	329.0	COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria,4E2Y1@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
GDHHQS2_k127_4134894_6	502025.Hoch_1290	1.227e-71	256.0	COG2227@1|root,COG2227@2|Bacteria,1R0J0@1224|Proteobacteria,430MG@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
GDHHQS2_k127_4134894_2	1394178.AWOO02000003_gene2575	7.246e-122	402.0	COG0179@1|root,COG0179@2|Bacteria,2GNGC@201174|Actinobacteria,4EFYU@85012|Streptosporangiales	201174|Actinobacteria	Q	Fumarylacetoacetase N-terminal	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
GDHHQS2_k127_4134894_1	1449976.KALB_2089	1.092e-133	437.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4E1ST@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_4134894_0	1229780.BN381_130116	5.001e-290	910.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,3UX5K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
GDHHQS2_k127_4141532_2	1284352.AOIG01000015_gene4177	7.444e-12	70.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,26XEB@186822|Paenibacillaceae	91061|Bacilli	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
GDHHQS2_k127_4141532_1	1003200.AXXA_28245	9.217e-78	265.0	COG1633@1|root,COG1633@2|Bacteria,1RB01@1224|Proteobacteria,2VQJI@28216|Betaproteobacteria,3T3JX@506|Alcaligenaceae	28216|Betaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
GDHHQS2_k127_4141532_0	1160137.KB907309_gene5407	2.112e-79	283.0	COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,4FWRE@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
GDHHQS2_k127_4158786_1	653733.Selin_0760	9.112e-60	215.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	dapC	-	2.6.1.11,2.6.1.17	ko:K00821,ko:K14267	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_4158786_0	298653.Franean1_1082	4.173e-192	622.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4ES5B@85013|Frankiales	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
GDHHQS2_k127_4173366_0	246196.MSMEI_0640	1.635e-109	364.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,236RV@1762|Mycobacteriaceae	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
GDHHQS2_k127_4176754_2	697284.ERIC2_c27640	6.755e-29	121.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4HAUV@91061|Bacilli,26Q9M@186822|Paenibacillaceae	91061|Bacilli	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
GDHHQS2_k127_4176754_1	1229780.BN381_50132	4.245e-36	151.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,3UWXN@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	Shikimate dehydrogenase substrate binding domain	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
GDHHQS2_k127_4176754_4	1499967.BAYZ01000180_gene4404	1.033e-08	67.0	COG0457@1|root,COG0457@2|Bacteria	1499967.BAYZ01000180_gene4404|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4176754_3	446469.Sked_17810	4.602e-17	90.0	COG1989@1|root,COG1989@2|Bacteria,2GJ7K@201174|Actinobacteria	201174|Actinobacteria	NOU	Peptidase A24A, prepilin type IV	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
GDHHQS2_k127_4176754_0	1193181.BN10_500027	3.993e-135	440.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4FEAA@85021|Intrasporangiaceae	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
GDHHQS2_k127_4176754_5	1380391.JIAS01000014_gene2139	9.129e-08	55.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,2JS5E@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
GDHHQS2_k127_4179856_1	1040983.AXAE01000005_gene1486	1.146e-28	118.0	COG1786@1|root,COG1786@2|Bacteria,1N5DN@1224|Proteobacteria,2UGA7@28211|Alphaproteobacteria,43KBA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
GDHHQS2_k127_4179856_0	1280686.AUKE01000007_gene1770	7.716e-123	402.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,4BXI4@830|Butyrivibrio	186801|Clostridia	M	3-beta hydroxysteroid dehydrogenase/isomerase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
GDHHQS2_k127_4195223_0	298654.FraEuI1c_5020	3.426e-101	342.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4ES5P@85013|Frankiales	201174|Actinobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
GDHHQS2_k127_4195223_2	649638.Trad_2529	3.817e-47	179.0	COG1028@1|root,COG1028@2|Bacteria,1WI3C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Short-chain Dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
GDHHQS2_k127_4195223_3	235985.BBPN01000005_gene2837	2.285e-24	108.0	COG4319@1|root,COG4319@2|Bacteria,2INEA@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
GDHHQS2_k127_4195223_1	1121377.KB906405_gene132	1.523e-66	233.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
GDHHQS2_k127_4196432_2	314264.ROS217_09090	3.539e-12	69.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2TSRT@28211|Alphaproteobacteria,46NHU@74030|Roseovarius	28211|Alphaproteobacteria	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS2_k127_4196432_1	1499967.BAYZ01000014_gene6413	2.45e-79	275.0	COG0411@1|root,COG0411@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS2_k127_4196432_0	1128421.JAGA01000002_gene1296	7.049e-99	332.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_4197686_0	640132.Srot_1582	3.317e-97	325.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_4197686_1	756883.Halar_1739	1.22e-08	66.0	COG0697@1|root,arCOG00272@2157|Archaea	2157|Archaea	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS2_k127_4197686_2	290315.Clim_1314	8.78e-07	60.0	COG1917@1|root,COG1917@2|Bacteria,1FE3K@1090|Chlorobi	1090|Chlorobi	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_4197686_3	298653.Franean1_4745	0.0009153	44.0	COG3971@1|root,COG3971@2|Bacteria,2GPBI@201174|Actinobacteria,4ESJD@85013|Frankiales	201174|Actinobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	mhpD	-	4.1.1.77,4.2.1.80	ko:K01617,ko:K02509,ko:K02554	ko00350,ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00350,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R02602,R04132,R04781,R05374,R06897	RC00750,RC00751,RC01213,RC01615,RC02595,RC02672	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
GDHHQS2_k127_4210088_1	670487.Ocepr_2131	1.386e-35	140.0	COG0492@1|root,COG0492@2|Bacteria,1WI0B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
GDHHQS2_k127_4210088_0	935261.JAGL01000008_gene2343	3.633e-148	481.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,43NJ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
GDHHQS2_k127_4210088_3	935840.JAEQ01000020_gene2336	3.625e-21	96.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,43NJ4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
GDHHQS2_k127_4210088_2	1045009.AFXQ01000007_gene2882	2.346e-31	135.0	COG0715@1|root,COG0715@2|Bacteria,2HH8J@201174|Actinobacteria,1W8W9@1268|Micrococcaceae	201174|Actinobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
GDHHQS2_k127_4216692_0	1123023.JIAI01000003_gene2647	9.105e-96	319.0	COG4670@1|root,COG4670@2|Bacteria	2|Bacteria	I	ketone body catabolic process	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
GDHHQS2_k127_4216692_1	1123023.JIAI01000003_gene2648	1.195e-78	270.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4E1EZ@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
GDHHQS2_k127_4216692_2	1445613.JALM01000020_gene4722	2.45e-60	221.0	COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E3AX@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_4232472_1	1245475.ANAE01000106_gene2706	3.185e-48	180.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4EH3N@85012|Streptosporangiales	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
GDHHQS2_k127_4232472_0	485913.Krac_4004	8.937e-99	332.0	COG1018@1|root,COG1018@2|Bacteria,2G7Q7@200795|Chloroflexi	200795|Chloroflexi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
GDHHQS2_k127_4232472_2	1132441.KI519454_gene1417	3.749e-10	65.0	2E4G6@1|root,32ZBB@2|Bacteria,2GR6E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4242116_0	1541065.JRFE01000023_gene3740	1.247e-22	110.0	COG2931@1|root,COG2931@2|Bacteria,1G2GC@1117|Cyanobacteria,3VKZ9@52604|Pleurocapsales	1117|Cyanobacteria	Q	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,FG-GAP
GDHHQS2_k127_4243496_1	469383.Cwoe_1670	1.419e-12	70.0	COG0789@1|root,COG2114@1|root,COG0789@2|Bacteria,COG2114@2|Bacteria,2ICT6@201174|Actinobacteria,4CR4V@84995|Rubrobacteria	84995|Rubrobacteria	KT	Adenylate cyclase regulatory domain	-	-	-	-	-	-	-	-	-	-	-	-	Ad_Cy_reg,Guanylate_cyc,MerR_1
GDHHQS2_k127_4243496_0	471852.Tcur_3102	3.353e-163	519.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4EFP6@85012|Streptosporangiales	201174|Actinobacteria	E	Glutamine synthetase, beta-Grasp domain	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
GDHHQS2_k127_4251130_2	479431.Namu_0352	3.164e-56	198.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4EWZZ@85013|Frankiales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
GDHHQS2_k127_4251130_0	882083.SacmaDRAFT_3637	6.419e-90	307.0	COG2239@1|root,COG2239@2|Bacteria,2I9TV@201174|Actinobacteria,4EEP1@85010|Pseudonocardiales	201174|Actinobacteria	P	Divalent cation transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE
GDHHQS2_k127_4251130_1	1122182.KB903823_gene1392	1.491e-82	282.0	COG0477@1|root,COG2814@2|Bacteria,2I7XA@201174|Actinobacteria,4DCHW@85008|Micromonosporales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_4251636_0	1380370.JIBA01000012_gene3620	3.946e-123	398.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4FEUC@85021|Intrasporangiaceae	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
GDHHQS2_k127_4251636_1	1382306.JNIM01000001_gene3583	1.189e-98	344.0	COG0578@1|root,COG0578@2|Bacteria	2|Bacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
GDHHQS2_k127_4251636_3	1380390.JIAT01000010_gene4305	4.457e-40	155.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4CQIK@84995|Rubrobacteria	84995|Rubrobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
GDHHQS2_k127_4251636_2	1380390.JIAT01000010_gene4306	8.306e-77	276.0	COG0451@1|root,COG0451@2|Bacteria,2GN90@201174|Actinobacteria,4CRU1@84995|Rubrobacteria	84995|Rubrobacteria	M	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
GDHHQS2_k127_4251636_4	1211115.ALIQ01000007_gene1078	5.181e-24	106.0	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	protein possibly involved in aromatic compounds catabolism	MA20_36950	-	-	-	-	-	-	-	-	-	-	-	4HBT
GDHHQS2_k127_4251636_5	1121272.KB903289_gene4139	1.543e-20	94.0	COG0789@1|root,COG0789@2|Bacteria,2IC98@201174|Actinobacteria,4DGJB@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
GDHHQS2_k127_4252531_1	471852.Tcur_2490	4.855e-23	100.0	COG2224@1|root,COG2224@2|Bacteria,2GNAY@201174|Actinobacteria,4EG9A@85012|Streptosporangiales	201174|Actinobacteria	C	Isocitrate lyase family	aceA	GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0006950,GO:0008150,GO:0008152,GO:0009268,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0010033,GO:0010034,GO:0010447,GO:0016020,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019899,GO:0032787,GO:0033554,GO:0033993,GO:0035375,GO:0036293,GO:0036294,GO:0042221,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046421,GO:0046487,GO:0046677,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0070542,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071944,GO:0072350,GO:0075136,GO:0075141,GO:1901700	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
GDHHQS2_k127_4252531_0	867903.ThesuDRAFT_01477	3.328e-135	436.0	COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,24Z0I@186801|Clostridia	186801|Clostridia	H	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
GDHHQS2_k127_4252924_0	326424.FRAAL2180	1.801e-288	917.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4ERJ2@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
GDHHQS2_k127_4258885_6	631454.N177_4104	1.522e-57	203.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,1JNV6@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
GDHHQS2_k127_4258885_5	1123060.JONP01000024_gene2526	2.661e-78	271.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,2JS33@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
GDHHQS2_k127_4258885_7	1122138.AQUZ01000049_gene2385	9.649e-37	151.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4DQ7D@85009|Propionibacteriales	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
GDHHQS2_k127_4258885_8	1071085.KK033114_gene736	2.059e-36	145.0	arCOG08934@1|root,arCOG08934@2157|Archaea,2XXBA@28890|Euryarchaeota	28890|Euryarchaeota	Q	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
GDHHQS2_k127_4258885_3	702113.PP1Y_AT33092	1.416e-99	335.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,2K1BU@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM amidohydrolase 2	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
GDHHQS2_k127_4258885_2	1125973.JNLC01000011_gene592	1.148e-118	402.0	COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS2_k127_4258885_1	1125973.JNLC01000011_gene593	2.314e-129	428.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2TV6R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS2_k127_4258885_0	1205680.CAKO01000035_gene262	1.034e-162	525.0	COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
GDHHQS2_k127_4258885_9	1123023.JIAI01000019_gene2232	1.299e-24	108.0	2E6FA@1|root,3312Q@2|Bacteria,2GUWJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4258885_10	1229780.BN381_210066	9.124e-17	82.0	2DS3D@1|root,33EC4@2|Bacteria,2GXNR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4258885_4	526227.Mesil_0281	1.223e-98	332.0	COG0604@1|root,COG0604@2|Bacteria,1WIQ2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS2_k127_4258885_11	1231391.AMZF01000018_gene1832	2.817e-08	55.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VTNQ@28216|Betaproteobacteria,3T83X@506|Alcaligenaceae	28216|Betaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
GDHHQS2_k127_4281892_0	67373.JOBF01000003_gene168	3.039e-75	261.0	COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
GDHHQS2_k127_4281892_1	1313172.YM304_25510	2.405e-16	82.0	COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNFE@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_4294871_1	1380394.JADL01000013_gene635	6.671e-36	139.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2U2QW@28211|Alphaproteobacteria,2JV3N@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS2_k127_4294871_0	10036.XP_005079958.1	7.46e-42	165.0	COG2159@1|root,KOG4245@2759|Eukaryota,38BZU@33154|Opisthokonta,3BAFS@33208|Metazoa,3CXVU@33213|Bilateria,484NQ@7711|Chordata,48Y8H@7742|Vertebrata,3JEKM@40674|Mammalia,35BQY@314146|Euarchontoglires,4PUAV@9989|Rodentia	33208|Metazoa	S	negative regulation of quinolinate biosynthetic process	ACMSD	GO:0001760,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006140,GO:0006520,GO:0006521,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009820,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016043,GO:0016053,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019439,GO:0019752,GO:0022607,GO:0030808,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0033238,GO:0034641,GO:0042402,GO:0042430,GO:0042436,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043648,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046874,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051186,GO:0051193,GO:0051196,GO:0051259,GO:0062012,GO:0062014,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0072330,GO:0072524,GO:0072525,GO:0080090,GO:0090357,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902688,GO:1904984,GO:1904985,GO:1905003,GO:1905004,GO:1905012	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
GDHHQS2_k127_4297667_2	1313172.YM304_17360	5.764e-20	95.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K03281,ko:K08714,ko:K16922	-	-	-	-	ko00000,ko01002,ko02000	1.A.1.14,2.A.49	-	-	CBS,Ion_trans,NTP_transferase,TIR-like,cNMP_binding
GDHHQS2_k127_4297667_0	1234364.AMSF01000095_gene2565	6.935e-114	372.0	COG0614@1|root,COG0614@2|Bacteria,1PK1A@1224|Proteobacteria,1RRDK@1236|Gammaproteobacteria,1X3UZ@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC transporter substrate-binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
GDHHQS2_k127_4297667_1	414684.RC1_1081	4.604e-59	211.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,2VGIH@28211|Alphaproteobacteria,2JS0H@204441|Rhodospirillales	204441|Rhodospirillales	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
GDHHQS2_k127_4297667_3	1229780.BN381_350095	0.0005081	44.0	COG0526@1|root,COG0526@2|Bacteria,2H8ZP@201174|Actinobacteria	201174|Actinobacteria	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4298185_0	696747.NIES39_Q02320	5.499e-147	478.0	COG0304@1|root,COG0304@2|Bacteria,1G1J5@1117|Cyanobacteria,1H7C2@1150|Oscillatoriales	1117|Cyanobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
GDHHQS2_k127_4298185_4	1078083.HMPREF1208_00622	3.028e-13	81.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,4HNQ0@91061|Bacilli,4GZNZ@90964|Staphylococcaceae	91061|Bacilli	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
GDHHQS2_k127_4298185_2	525903.Taci_1097	9.811e-85	287.0	COG1028@1|root,COG1028@2|Bacteria,3TAAZ@508458|Synergistetes	508458|Synergistetes	IQ	TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS2_k127_4298185_1	382245.ASA_3262	1.862e-117	389.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1Y51Z@135624|Aeromonadales	135624|Aeromonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
GDHHQS2_k127_4298185_3	1122927.KB895418_gene2631	9.203e-55	204.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,26QJX@186822|Paenibacillaceae	91061|Bacilli	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
GDHHQS2_k127_4301410_1	1206735.BAGG01000046_gene1941	1.799e-55	197.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4FVI4@85025|Nocardiaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
GDHHQS2_k127_4301410_0	351607.Acel_0095	5.009e-81	279.0	COG1680@1|root,COG1680@2|Bacteria,2GNVX@201174|Actinobacteria,4ESEV@85013|Frankiales	201174|Actinobacteria	V	PFAM Beta-lactamase	bla	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
GDHHQS2_k127_4301410_2	1540221.JQNI01000002_gene1145	3.68e-44	165.0	COG0490@1|root,COG0490@2|Bacteria	2|Bacteria	P	domain, Protein	khtT	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
GDHHQS2_k127_4301410_3	1210045.ALNP01000024_gene555	6.28e-43	162.0	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria	201174|Actinobacteria	P	Pfam Sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
GDHHQS2_k127_4301991_0	326424.FRAAL6579	8.288e-246	776.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4ES4C@85013|Frankiales	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
GDHHQS2_k127_4302214_3	1068978.AMETH_6570	2.358e-32	132.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,4E4Z9@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
GDHHQS2_k127_4302214_4	1229780.BN381_110026	3.782e-24	115.0	2F3QB@1|root,33WH4@2|Bacteria,2H50W@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4302214_1	644282.Deba_0763	1.263e-74	265.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
GDHHQS2_k127_4302214_2	643648.Slip_1211	2.253e-74	255.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,42JU1@68298|Syntrophomonadaceae	186801|Clostridia	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
GDHHQS2_k127_4302214_0	351607.Acel_0204	3.309e-113	374.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4ERQQ@85013|Frankiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
GDHHQS2_k127_4311210_1	1089544.KB912942_gene3984	7.389e-122	396.0	COG1024@1|root,COG1024@2|Bacteria,2GJ7Z@201174|Actinobacteria,4E2EI@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA5	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
GDHHQS2_k127_4311210_0	1068980.ARVW01000001_gene858	7.928e-168	550.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,NAD_binding_8,Oxidored_FMN
GDHHQS2_k127_4311210_2	1068980.ARVW01000001_gene857	1.136e-39	149.0	COG2141@1|root,COG2141@2|Bacteria,2HVKH@201174|Actinobacteria	201174|Actinobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_4313269_0	266117.Rxyl_2480	2.909e-95	337.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4CT3Y@84995|Rubrobacteria	84995|Rubrobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
GDHHQS2_k127_4313269_1	1521187.JPIM01000149_gene408	8.499e-92	327.0	COG0022@1|root,COG0022@2|Bacteria,2G5JU@200795|Chloroflexi,374SG@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Transketolase central region	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS2_k127_431442_1	469383.Cwoe_3712	2.077e-12	79.0	COG2244@1|root,COG2244@2|Bacteria,2HRC7@201174|Actinobacteria,4CT9N@84995|Rubrobacteria	84995|Rubrobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
GDHHQS2_k127_431442_0	1229780.BN381_470014	3.764e-22	108.0	COG1404@1|root,COG5184@1|root,COG1404@2|Bacteria,COG5184@2|Bacteria,2IG31@201174|Actinobacteria,3UXAU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	DOZ	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,RCC1,RCC1_2,SLH
GDHHQS2_k127_4315497_1	446469.Sked_30380	4.183e-33	129.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	-	-	2.6.1.1,2.6.1.17,2.6.1.83	ko:K00812,ko:K08969,ko:K10206,ko:K14261,ko:K14267	ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00034,M00527	R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052,R07396,R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_4315497_0	404589.Anae109_3740	6.36e-87	299.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria,2YUBW@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
GDHHQS2_k127_4318765_0	1380393.JHVP01000001_gene2302	1.529e-53	203.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,cNMP_binding
GDHHQS2_k127_4318765_1	465541.ATCJ01000005_gene1044	4.843e-52	189.0	COG0492@1|root,COG0492@2|Bacteria,2GK62@201174|Actinobacteria	201174|Actinobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
GDHHQS2_k127_4320323_0	1121287.AUMU01000006_gene3630	6.839e-21	108.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1HYZK@117743|Flavobacteriia,3ZPSF@59732|Chryseobacterium	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,CHASE3,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,TPR_12
GDHHQS2_k127_4324819_4	82654.Pse7367_0377	2.436e-06	52.0	COG0533@1|root,COG0533@2|Bacteria,1G0EF@1117|Cyanobacteria,1H7TB@1150|Oscillatoriales	1117|Cyanobacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
GDHHQS2_k127_4324819_2	1313172.YM304_08950	6.022e-37	145.0	COG0454@1|root,COG0456@2|Bacteria,2HGCA@201174|Actinobacteria,4CNAC@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
GDHHQS2_k127_4324819_1	1229780.BN381_130031	1.811e-38	155.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,3UWTU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
GDHHQS2_k127_4324819_3	1380393.JHVP01000002_gene1822	1.165e-33	135.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4ESZ5@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
GDHHQS2_k127_4324819_0	1235794.C811_01078	1.537e-54	199.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4CUM5@84998|Coriobacteriia	84998|Coriobacteriia	L	Uracil-DNA glycosylase, family 4	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
GDHHQS2_k127_4327614_1	1123065.ATWL01000004_gene2873	1.898e-36	147.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
GDHHQS2_k127_4327614_0	525904.Tter_2687	1.358e-51	189.0	COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria	2|Bacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS2_k127_4327766_1	471852.Tcur_0550	1.389e-43	162.0	COG2227@1|root,COG2227@2|Bacteria,2I3C3@201174|Actinobacteria,4ER5A@85012|Streptosporangiales	201174|Actinobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
GDHHQS2_k127_4327766_2	443218.AS9A_2782	1.273e-29	125.0	2DZHZ@1|root,31ZDG@2|Bacteria,2IN6I@201174|Actinobacteria,23A9W@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4327766_3	42256.RradSPS_2294	3.736e-27	123.0	COG0454@1|root,COG0456@2|Bacteria,2IQQX@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
GDHHQS2_k127_4327766_4	1313172.YM304_18100	5.479e-25	109.0	COG0640@1|root,COG0640@2|Bacteria,2IKK2@201174|Actinobacteria,4CNZ5@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4327766_0	1449976.KALB_5448	4.195e-175	558.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2GYM5@201174|Actinobacteria,4DXS6@85010|Pseudonocardiales	201174|Actinobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
GDHHQS2_k127_4328086_0	767817.Desgi_2802	4.203e-71	250.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,2610G@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
GDHHQS2_k127_4328086_1	1313172.YM304_18670	3.791e-50	186.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4CN7Y@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
GDHHQS2_k127_4332111_0	1211815.CBYP010000067_gene136	2.073e-147	486.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,2GN7D@201174|Actinobacteria,4ERUR@85013|Frankiales	201174|Actinobacteria	EH	PFAM chorismate	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Chorismate_bind
GDHHQS2_k127_4332111_2	526225.Gobs_1392	5.29e-56	198.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4ET6N@85013|Frankiales	201174|Actinobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_4332111_1	1313172.YM304_07180	8.203e-101	336.0	COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	rutA_3	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_4335065_1	543632.JOJL01000002_gene8363	4.086e-08	60.0	COG1331@1|root,COG1331@2|Bacteria,2I5YD@201174|Actinobacteria,4DMTH@85008|Micromonosporales	201174|Actinobacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4335065_0	298655.KI912266_gene3883	7.284e-89	305.0	COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria,4ETRT@85013|Frankiales	201174|Actinobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
GDHHQS2_k127_4373370_3	1235792.C808_00047	0.0002876	48.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia,27K1Y@186928|unclassified Lachnospiraceae	186801|Clostridia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
GDHHQS2_k127_4373370_2	1463921.JODF01000012_gene319	2.623e-42	166.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
GDHHQS2_k127_4373370_0	446470.Snas_5606	2.123e-91	307.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4EZNM@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
GDHHQS2_k127_4373370_1	1123023.JIAI01000003_gene2635	9.932e-47	178.0	COG0600@1|root,COG0600@2|Bacteria,2GKKZ@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
GDHHQS2_k127_4380408_0	926564.KI911740_gene3432	2.424e-38	148.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4F4JP@85017|Promicromonosporaceae	201174|Actinobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
GDHHQS2_k127_4380408_1	37919.EP51_10760	5.831e-37	143.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4FXX7@85025|Nocardiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_4381812_0	644966.Tmar_0300	2.411e-94	320.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,3WD17@538999|Clostridiales incertae sedis	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
GDHHQS2_k127_4381812_1	710687.KI912270_gene1977	3.631e-17	88.0	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,239Z5@1762|Mycobacteriaceae	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
GDHHQS2_k127_4407376_0	873533.HMPREF0663_12066	2.604e-21	98.0	COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,2FM5R@200643|Bacteroidia	976|Bacteroidetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
GDHHQS2_k127_4407376_2	1304875.JAFZ01000001_gene1405	1.815e-09	68.0	COG3599@1|root,COG3599@2|Bacteria,3TBCR@508458|Synergistetes	508458|Synergistetes	D	DivIVA domain	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
GDHHQS2_k127_4407376_1	1121422.AUMW01000017_gene1967	9.442e-12	73.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,261ZS@186807|Peptococcaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
GDHHQS2_k127_44152_2	43354.JOIJ01000007_gene1705	8.89e-19	87.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4DYA4@85010|Pseudonocardiales	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C
GDHHQS2_k127_44152_0	469371.Tbis_1708	5.565e-131	438.0	COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4DYET@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
GDHHQS2_k127_44152_1	469371.Tbis_1717	4.75e-83	286.0	COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4DY9A@85010|Pseudonocardiales	201174|Actinobacteria	HQ	chorismate binding enzyme	menF	-	5.4.4.2	ko:K02361,ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
GDHHQS2_k127_4429209_1	1346791.M529_12370	2.772e-12	78.0	COG1413@1|root,COG1413@2|Bacteria,1N7UC@1224|Proteobacteria,2UGUW@28211|Alphaproteobacteria,2KA0S@204457|Sphingomonadales	204457|Sphingomonadales	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
GDHHQS2_k127_4429209_0	1229520.ADIAL_1391	1.264e-104	361.0	COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,4HAQN@91061|Bacilli,27H8T@186828|Carnobacteriaceae	91061|Bacilli	M	Chitin synthase	ica2	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
GDHHQS2_k127_4436893_0	1229780.BN381_140043	1.566e-69	250.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
GDHHQS2_k127_4436893_1	365528.KB891203_gene3432	2.922e-11	67.0	2EGHN@1|root,33A9R@2|Bacteria,2GSZ1@201174|Actinobacteria,4ETGC@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4456290_2	1316936.K678_01601	2.259e-30	137.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,2JPAZ@204441|Rhodospirillales	204441|Rhodospirillales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
GDHHQS2_k127_4456290_1	1121877.JQKF01000023_gene2244	1.313e-48	179.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4CN7F@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
GDHHQS2_k127_4456290_0	188626.HMPREF0321_1904	1.798e-64	232.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,1ZVQY@145357|Dermacoccaceae	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
GDHHQS2_k127_4463800_5	323098.Nwi_2024	2.168e-16	81.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria,3JTTZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
GDHHQS2_k127_4463800_6	859657.RPSI07_mp0907	2.383e-13	83.0	COG0477@1|root,COG2814@2|Bacteria,1R8RS@1224|Proteobacteria,2VK2W@28216|Betaproteobacteria,1KEJN@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_4463800_2	426117.M446_0531	2.559e-54	201.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2TU74@28211|Alphaproteobacteria,1JZD9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM alpha beta hydrolase fold	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
GDHHQS2_k127_4463800_1	101510.RHA1_ro11181	8.995e-55	203.0	COG0447@1|root,COG0447@2|Bacteria,2HGHM@201174|Actinobacteria,4FZY1@85025|Nocardiaceae	201174|Actinobacteria	H	Enoyl-CoA hydratase/isomerase	-	-	4.1.3.36	ko:K01661,ko:K07536	ko00130,ko00362,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map01100,map01110,map01120,map01220	M00116,M00540	R05592,R07263	RC01429,RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
GDHHQS2_k127_4463800_0	479434.Sthe_3003	1.339e-125	415.0	COG1804@1|root,COG1804@2|Bacteria,2GABR@200795|Chloroflexi,27XHH@189775|Thermomicrobia	189775|Thermomicrobia	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
GDHHQS2_k127_4463800_3	768706.Desor_4285	2.051e-38	156.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,26416@186807|Peptococcaceae	186801|Clostridia	G	extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
GDHHQS2_k127_4463800_4	1382304.JNIL01000001_gene1383	2.429e-33	136.0	COG1028@1|root,COG1028@2|Bacteria,1TSNP@1239|Firmicutes,4IPV4@91061|Bacilli	91061|Bacilli	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS2_k127_446956_1	224911.27352666	1.222e-21	96.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2TVXS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the peptidase S33 family	pipch2	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
GDHHQS2_k127_446956_0	1120934.KB894410_gene6920	1.81e-39	150.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5W6@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_446956_2	1463917.JODC01000007_gene7491	4.234e-17	82.0	COG3070@1|root,COG3070@2|Bacteria,2IKKV@201174|Actinobacteria	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
GDHHQS2_k127_4474399_0	443218.AS9A_4034	1.778e-11	72.0	COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,2336F@1762|Mycobacteriaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigD	GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
GDHHQS2_k127_4474399_1	1122221.JHVI01000003_gene304	1.665e-09	59.0	COG0566@1|root,COG0566@2|Bacteria,1WJ5I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind,TSNR_N
GDHHQS2_k127_4489822_1	263358.VAB18032_06925	6.488e-11	68.0	COG3795@1|root,COG3795@2|Bacteria,2GSB0@201174|Actinobacteria,4DG26@85008|Micromonosporales	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
GDHHQS2_k127_4489822_0	255470.cbdbA928	1.231e-65	242.0	COG0514@1|root,COG1205@1|root,COG0514@2|Bacteria,COG1205@2|Bacteria,2G605@200795|Chloroflexi,34CMG@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
GDHHQS2_k127_4491075_0	1051632.TPY_1473	6.452e-50	188.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
GDHHQS2_k127_4493442_0	1054213.HMPREF9946_02427	2.498e-96	328.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TVS9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_4493442_3	1504981.KO116_3559	4.898e-15	81.0	COG2030@1|root,COG2030@2|Bacteria,1QXYH@1224|Proteobacteria,1T3KN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	4.2.1.153	ko:K09709	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09282	RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
GDHHQS2_k127_4493442_2	930169.B5T_00174	5.338e-23	105.0	COG3777@1|root,COG3777@2|Bacteria,1RIJT@1224|Proteobacteria	1224|Proteobacteria	S	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4493442_1	1120949.KB903357_gene4895	2.38e-42	159.0	COG0028@1|root,COG0028@2|Bacteria,2I9V6@201174|Actinobacteria	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
GDHHQS2_k127_4497155_1	1121920.AUAU01000005_gene967	1.564e-63	222.0	COG3795@1|root,COG3795@2|Bacteria,3Y517@57723|Acidobacteria	57723|Acidobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
GDHHQS2_k127_4497155_0	215803.DB30_4220	1.146e-73	251.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,437V1@68525|delta/epsilon subdivisions,2X34I@28221|Deltaproteobacteria,2YU7X@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_4511668_2	545276.KB898726_gene1054	1.226e-13	74.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,1WY50@135613|Chromatiales	135613|Chromatiales	T	low molecular weight	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
GDHHQS2_k127_4511668_1	196162.Noca_0231	1.411e-69	247.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,2IA9U@201174|Actinobacteria,4DUZB@85009|Propionibacteriales	201174|Actinobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
GDHHQS2_k127_4511668_0	502025.Hoch_2000	1.746e-155	495.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
GDHHQS2_k127_4513293_0	493475.GARC_1984	4.114e-94	326.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,468GY@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	POTRA,Patatin,cNMP_binding
GDHHQS2_k127_451808_1	525909.Afer_1985	5.113e-27	113.0	COG1846@1|root,COG1846@2|Bacteria,2IMGG@201174|Actinobacteria,4CNB4@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
GDHHQS2_k127_451808_0	530564.Psta_2116	7.048e-56	202.0	COG0475@1|root,COG0475@2|Bacteria,2IY97@203682|Planctomycetes	203682|Planctomycetes	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
GDHHQS2_k127_4519154_1	525904.Tter_1217	3.147e-66	241.0	COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria	2|Bacteria	S	Vacuole effluxer Atg22 like	yxiO	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22,MFS_1
GDHHQS2_k127_4519154_2	1333998.M2A_2795	2.534e-61	226.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,4BSFK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	MA20_31690	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
GDHHQS2_k127_4519154_0	105420.BBPO01000022_gene5822	6.245e-157	503.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,2NHQV@228398|Streptacidiphilus	201174|Actinobacteria	E	Cys/Met metabolism PLP-dependent enzyme	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_4536213_3	1380356.JNIK01000016_gene3627	5.979e-29	123.0	COG3860@1|root,COG3860@2|Bacteria,2IQEK@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_20
GDHHQS2_k127_4536213_5	754252.PFREUD_10500	1.321e-18	89.0	COG0355@1|root,COG0355@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
GDHHQS2_k127_4536213_1	1380393.JHVP01000002_gene1506	2.682e-207	653.0	COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4ES4I@85013|Frankiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
GDHHQS2_k127_4536213_2	298655.KI912266_gene2131	4.053e-71	250.0	COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,4ERNM@85013|Frankiales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
GDHHQS2_k127_4536213_0	710687.KI912270_gene144	2.099e-214	676.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,234FD@1762|Mycobacteriaceae	201174|Actinobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
GDHHQS2_k127_4536213_4	1313172.YM304_10630	2.091e-25	109.0	COG0712@1|root,COG0712@2|Bacteria,2HGFG@201174|Actinobacteria,4CND3@84992|Acidimicrobiia	84992|Acidimicrobiia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
GDHHQS2_k127_4544554_0	266117.Rxyl_1174	2.006e-81	284.0	COG1178@1|root,COG1178@2|Bacteria,2GKPT@201174|Actinobacteria	201174|Actinobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
GDHHQS2_k127_4544554_1	42256.RradSPS_1163	3.673e-52	188.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
GDHHQS2_k127_4557741_1	1279038.KB907356_gene1994	4.047e-81	273.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2TUDG@28211|Alphaproteobacteria,2JQQB@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_4557741_0	1380394.JADL01000020_gene1826	1.383e-115	384.0	COG0742@1|root,COG0742@2|Bacteria,1MW6A@1224|Proteobacteria,2TQNI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	ribosomal rna small subunit methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4559654_0	1128421.JAGA01000003_gene3250	3.695e-108	359.0	COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria	2|Bacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
GDHHQS2_k127_4559654_3	316274.Haur_0252	3.646e-43	171.0	COG1721@1|root,COG1721@2|Bacteria,2GACI@200795|Chloroflexi,375AS@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
GDHHQS2_k127_4559654_2	1128421.JAGA01000003_gene3247	4.124e-53	211.0	COG2304@1|root,COG2304@2|Bacteria,2NQHG@2323|unclassified Bacteria	2|Bacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
GDHHQS2_k127_4559654_1	1128421.JAGA01000003_gene3234	8.434e-77	278.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2NQSS@2323|unclassified Bacteria	2|Bacteria	S	Putative glutamine amidotransferase	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
GDHHQS2_k127_4568770_1	1229780.BN381_130079	2.088e-74	257.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria,3UXG4@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
GDHHQS2_k127_4568770_0	1128421.JAGA01000003_gene2923	1.752e-161	514.0	COG1053@1|root,COG1053@2|Bacteria,2NQMR@2323|unclassified Bacteria	2|Bacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
GDHHQS2_k127_45807_0	1206101.AZXC01000010_gene118	4.185e-76	265.0	COG3285@1|root,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase LigD polymerase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_primase_S
GDHHQS2_k127_4583402_3	2850.Phatr37632	8.442e-63	224.0	COG1814@1|root,KOG4473@2759|Eukaryota,2XC42@2836|Bacillariophyta	2836|Bacillariophyta	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
GDHHQS2_k127_4583402_1	292459.STH1417	8.994e-115	381.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia	186801|Clostridia	E	PFAM DAHP synthetase I	aroF1	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
GDHHQS2_k127_4583402_4	477974.Daud_1182	2.357e-47	184.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,260K3@186807|Peptococcaceae	186801|Clostridia	E	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
GDHHQS2_k127_4583402_2	526225.Gobs_4375	8.929e-109	365.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4ESB6@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	amiA	-	-	ko:K01436,ko:K06048	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
GDHHQS2_k127_4583402_0	452863.Achl_1592	7.905e-172	573.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,1W7KP@1268|Micrococcaceae	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
GDHHQS2_k127_4583598_3	443218.AS9A_3448	3.5e-98	331.0	COG0265@1|root,COG0265@2|Bacteria,2IB8S@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like peptidase domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
GDHHQS2_k127_4583598_5	1123065.ATWL01000003_gene689	1.325e-26	115.0	2EGCD@1|root,33A46@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Septum_form
GDHHQS2_k127_4583598_0	1172181.KB911698_gene6061	1.289e-207	655.0	COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria	201174|Actinobacteria	F	Dihydropyrimidinase	hyuA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
GDHHQS2_k127_4583598_4	314345.SPV1_09643	5.093e-75	257.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria	1224|Proteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
GDHHQS2_k127_4583598_1	926569.ANT_31330	4.039e-121	399.0	COG1840@1|root,COG1840@2|Bacteria,2G65V@200795|Chloroflexi	200795|Chloroflexi	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
GDHHQS2_k127_4583598_2	371731.Rsw2DRAFT_1135	7.677e-119	390.0	COG1840@1|root,COG1840@2|Bacteria,1Q13Q@1224|Proteobacteria,2TS7Y@28211|Alphaproteobacteria,1FB0G@1060|Rhodobacter	28211|Alphaproteobacteria	P	extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_6
GDHHQS2_k127_4585898_0	675635.Psed_3940	1.122e-47	179.0	COG2380@1|root,COG2380@2|Bacteria,2I8F9@201174|Actinobacteria,4E8J3@85010|Pseudonocardiales	201174|Actinobacteria	S	COGs COG2380 conserved	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4585898_1	391037.Sare_1496	1.89e-28	117.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4DA3T@85008|Micromonosporales	201174|Actinobacteria	L	Putative exonuclease SbcCD, C subunit	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
GDHHQS2_k127_4601657_1	1128421.JAGA01000002_gene315	7.553e-45	180.0	COG0842@1|root,COG0842@2|Bacteria,2NPA6@2323|unclassified Bacteria	2|Bacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
GDHHQS2_k127_4601657_0	1128421.JAGA01000002_gene314	1.892e-86	296.0	COG1131@1|root,COG1131@2|Bacteria,2NQPB@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS2_k127_4602131_0	1313172.YM304_18530	1.04e-163	534.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CMPC@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
GDHHQS2_k127_4602131_1	649831.L083_6917	2.72e-10	64.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
GDHHQS2_k127_4610745_1	1205910.B005_4727	0.0005876	47.0	COG2452@1|root,COG2452@2|Bacteria,2I537@201174|Actinobacteria	201174|Actinobacteria	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
GDHHQS2_k127_4610745_0	1184609.KILIM_120_00050	1.252e-34	138.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria	201174|Actinobacteria	S	regulation of cellular protein catabolic process	bpa	GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369	-	-	-	-	-	-	-	-	-	-	DUF2587
GDHHQS2_k127_4624705_0	1229780.BN381_290089	1.225e-47	181.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,3UWFW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_CG,NAD_kinase
GDHHQS2_k127_4624705_1	211114.JOEF01000008_gene1367	7.319e-28	115.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4DY8F@85010|Pseudonocardiales	201174|Actinobacteria	J	TIGRFAM hemolysin TlyA family protein	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
GDHHQS2_k127_4632730_0	1380394.JADL01000010_gene4393	8.704e-150	498.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JV15@204441|Rhodospirillales	204441|Rhodospirillales	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
GDHHQS2_k127_4632730_1	1120950.KB892742_gene3009	7.07e-67	235.0	COG0412@1|root,COG0412@2|Bacteria,2GJMH@201174|Actinobacteria,4DQY9@85009|Propionibacteriales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
GDHHQS2_k127_4639351_1	1146883.BLASA_4848	4.993e-06	57.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria,4ES94@85013|Frankiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,GT87,Mannosyl_trans
GDHHQS2_k127_4639351_0	497964.CfE428DRAFT_2205	9.769e-112	388.0	COG1215@1|root,COG2227@1|root,COG1215@2|Bacteria,COG2227@2|Bacteria,46SRA@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GDHHQS2_k127_4639351_2	195253.Syn6312_1279	7.049e-05	53.0	2CC95@1|root,2Z8VE@2|Bacteria,1G2FQ@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4644465_1	1120936.KB907226_gene2883	2.041e-48	182.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4EFKK@85012|Streptosporangiales	201174|Actinobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	rip1	GO:0008150,GO:0040007	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
GDHHQS2_k127_4644465_0	1382304.JNIL01000001_gene573	5.861e-99	337.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4HBAV@91061|Bacilli,2788P@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
GDHHQS2_k127_4644465_2	1120985.AUMI01000015_gene1659	1.471e-16	81.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,4H4UZ@909932|Negativicutes	909932|Negativicutes	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
GDHHQS2_k127_4646249_3	485913.Krac_0284	6.807e-22	98.0	2DBV7@1|root,2ZB9P@2|Bacteria,2G97K@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
GDHHQS2_k127_4646249_0	1449346.JQMO01000003_gene4301	1.131e-94	316.0	COG1309@1|root,COG1309@2|Bacteria,2GV75@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
GDHHQS2_k127_4646249_1	1246995.AFR_36770	1.357e-60	222.0	COG0642@1|root,COG2972@1|root,COG2205@2|Bacteria,COG2972@2|Bacteria,2GIV9@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_4646249_2	1385520.N802_14440	4.435e-31	124.0	COG0745@1|root,COG0745@2|Bacteria,2GKYV@201174|Actinobacteria,4FIEM@85021|Intrasporangiaceae	201174|Actinobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_4648351_1	1173026.Glo7428_1096	4.624e-66	239.0	COG2931@1|root,COG4222@1|root,COG4247@1|root,COG2931@2|Bacteria,COG4222@2|Bacteria,COG4247@2|Bacteria,1G00S@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM Phytase	-	-	3.1.3.1,3.1.3.8,3.1.4.46	ko:K01083,ko:K01113,ko:K01126	ko00562,ko00564,ko00790,ko01100,ko02020,map00562,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R03371,R04620	RC00017,RC00078,RC00425	ko00000,ko00001,ko00002,ko01000	-	-	-	Calx-beta,DUF4114,Exo_endo_phos,GDPD,HemolysinCabind,PhoD,PhoD_N,Phytase,Phytase-like,SurE
GDHHQS2_k127_4648351_3	1347087.CBYO010000005_gene487	8.835e-33	133.0	COG4405@1|root,COG4405@2|Bacteria,1V6S0@1239|Firmicutes,4HKKR@91061|Bacilli	91061|Bacilli	P	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	ASCH,Rhodanese
GDHHQS2_k127_4648351_2	1123024.AUII01000025_gene2115	6.604e-45	176.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4DXB2@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Cell envelope-related transcriptional attenuator	lytR2	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
GDHHQS2_k127_4648351_0	1240349.ANGC01000001_gene2575	8.8e-67	236.0	COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
GDHHQS2_k127_4648351_4	1283299.AUKG01000001_gene2181	7.236e-28	118.0	COG1309@1|root,COG1309@2|Bacteria,2GM45@201174|Actinobacteria,4CR0R@84995|Rubrobacteria	84995|Rubrobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
GDHHQS2_k127_4650882_1	1120956.JHZK01000013_gene2560	6.637e-14	79.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2TV2G@28211|Alphaproteobacteria,1JPAE@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	MobA-like NTP transferase domain	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
GDHHQS2_k127_4650882_0	1382304.JNIL01000001_gene3015	3.152e-141	455.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,4HAKQ@91061|Bacilli,279ER@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
GDHHQS2_k127_4653791_3	1122175.ATXU01000002_gene1349	6.013e-06	48.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4FP2S@85023|Microbacteriaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
GDHHQS2_k127_4653791_1	1121106.JQKB01000019_gene2867	1.675e-69	246.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,2JQJW@204441|Rhodospirillales	204441|Rhodospirillales	O	ABC transporter	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
GDHHQS2_k127_4653791_2	1142394.PSMK_27020	2.756e-59	220.0	COG1363@1|root,COG1363@2|Bacteria	2|Bacteria	G	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28,Peptidase_M42
GDHHQS2_k127_4653791_0	446470.Snas_0839	3.679e-160	518.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,4EZ5J@85014|Glycomycetales	201174|Actinobacteria	C	Fumarase C C-terminus	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
GDHHQS2_k127_4667576_1	909613.UO65_1308	5.147e-52	199.0	COG0477@1|root,COG2814@2|Bacteria,2I5F8@201174|Actinobacteria,4E5MI@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_4667576_2	1348663.KCH_35040	1.014e-09	66.0	COG0640@1|root,COG0640@2|Bacteria,2IPJR@201174|Actinobacteria,2M378@2063|Kitasatospora	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GDHHQS2_k127_4667576_0	926550.CLDAP_35110	3.344e-127	415.0	COG0205@1|root,COG0205@2|Bacteria,2G6CJ@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
GDHHQS2_k127_4669086_0	1048339.KB913029_gene4019	1.562e-37	153.0	COG0642@1|root,COG2205@2|Bacteria,2GMB9@201174|Actinobacteria,4ES5F@85013|Frankiales	201174|Actinobacteria	T	PAS PAC sensor signal transduction histidine kinase	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
GDHHQS2_k127_4669086_1	1187851.A33M_3731	8.934e-14	74.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
GDHHQS2_k127_4682692_0	1089553.Tph_c02430	8.761e-63	221.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,42EUQ@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	-	-	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_4682692_1	1313172.YM304_38600	6.112e-43	173.0	COG0642@1|root,COG2205@2|Bacteria,2I3JI@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
GDHHQS2_k127_4683503_2	751944.HALDL1_10940	5.234e-48	185.0	COG0318@1|root,arCOG00856@2157|Archaea,2XST5@28890|Euryarchaeota,23SBA@183963|Halobacteria	183963|Halobacteria	I	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
GDHHQS2_k127_4683503_0	471852.Tcur_2404	1.39e-154	499.0	COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4EI6I@85012|Streptosporangiales	201174|Actinobacteria	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
GDHHQS2_k127_4683503_1	929712.KI912613_gene3974	1.465e-59	222.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4CQ7T@84995|Rubrobacteria	84995|Rubrobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
GDHHQS2_k127_4684156_0	345341.KUTG_04078	3.025e-105	345.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4E11C@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS2_k127_4684156_1	765177.Desmu_0098	1.072e-07	59.0	COG1912@1|root,arCOG04309@2157|Archaea,2XQIS@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
GDHHQS2_k127_4690949_1	1229780.BN381_250051	3.26e-21	96.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria,3UX7Q@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
GDHHQS2_k127_4690949_0	1229780.BN381_250052	1.025e-77	269.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,3UXBM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
GDHHQS2_k127_4690949_2	644966.Tmar_0469	4.342e-06	55.0	COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia	186801|Clostridia	P	binding domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
GDHHQS2_k127_4696569_0	1313172.YM304_04910	1.336e-21	100.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_471023_3	644966.Tmar_0133	7.76e-20	96.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,3WD87@538999|Clostridiales incertae sedis	186801|Clostridia	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
GDHHQS2_k127_471023_1	1380393.JHVP01000012_gene2713	4.101e-60	213.0	COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4ESNA@85013|Frankiales	201174|Actinobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0003674,GO:0003824,GO:0004422,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0052657,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
GDHHQS2_k127_471023_2	1122611.KB903946_gene832	5.96e-35	143.0	COG0810@1|root,COG5002@1|root,COG0810@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4EHI2@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_471023_0	1146883.BLASA_0576	6.627e-63	224.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4ERQQ@85013|Frankiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
GDHHQS2_k127_4710652_2	1194165.CAJF01000017_gene3520	0.0007044	46.0	COG0366@1|root,COG0366@2|Bacteria,2GNEC@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
GDHHQS2_k127_4710652_0	1229780.BN381_80160	3.745e-82	280.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,3UWTI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
GDHHQS2_k127_4710652_1	446468.Ndas_0367	7.536e-15	74.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4EHUG@85012|Streptosporangiales	201174|Actinobacteria	K	Uncharacterized ACR, COG1678	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
GDHHQS2_k127_4718741_2	1032480.MLP_42920	7.201e-19	91.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2GJUZ@201174|Actinobacteria,4DNNW@85009|Propionibacteriales	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
GDHHQS2_k127_4718741_1	33898.JRHJ01000089_gene2620	1.732e-25	115.0	COG2345@1|root,COG2345@2|Bacteria,2HCEF@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GDHHQS2_k127_4718741_0	1142394.PSMK_18670	0.0	1131.0	COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
GDHHQS2_k127_4718741_3	1283283.ATXA01000010_gene4575	7.068e-16	82.0	COG2852@1|root,COG2852@2|Bacteria,2HTPC@201174|Actinobacteria,4EWPM@85013|Frankiales	201174|Actinobacteria	K	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
GDHHQS2_k127_4724750_0	1382356.JQMP01000003_gene1617	1.026e-45	181.0	COG2206@1|root,COG2206@2|Bacteria,2GBKK@200795|Chloroflexi	200795|Chloroflexi	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
GDHHQS2_k127_4728000_1	404589.Anae109_3310	1.97e-45	166.0	COG0546@1|root,COG0546@2|Bacteria,1RCPM@1224|Proteobacteria,42SYW@68525|delta/epsilon subdivisions,2WP6C@28221|Deltaproteobacteria	1224|Proteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
GDHHQS2_k127_4728000_2	390989.JOEG01000005_gene1916	3.607e-14	75.0	2E4G6@1|root,32ZBB@2|Bacteria,2GR6E@201174|Actinobacteria,4DFKH@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4728000_0	404589.Anae109_1054	1.392e-68	237.0	COG1018@1|root,COG1018@2|Bacteria,1R5FN@1224|Proteobacteria	1224|Proteobacteria	C	Oxidoreductase FAD-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
GDHHQS2_k127_4733932_3	1121272.KB903289_gene4214	1.551e-26	110.0	COG1011@1|root,COG1011@2|Bacteria,2GPJ4@201174|Actinobacteria,4DAVQ@85008|Micromonosporales	201174|Actinobacteria	S	Had-superfamily hydrolase, subfamily ia, variant 1	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase,Hydrolase_like
GDHHQS2_k127_4733932_0	1193181.BN10_680022	9.719e-135	435.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FFXF@85021|Intrasporangiaceae	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
GDHHQS2_k127_4733932_1	1122138.AQUZ01000003_gene399	1.303e-51	193.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4DQNH@85009|Propionibacteriales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
GDHHQS2_k127_4733932_2	1122138.AQUZ01000003_gene400	7.649e-47	184.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4DNU1@85009|Propionibacteriales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
GDHHQS2_k127_4740011_2	1449044.JMLE01000011_gene3399	7.877e-10	64.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,1W8BP@1268|Micrococcaceae	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL2	-	-	ko:K12953	-	-	-	-	ko00000,ko01000	3.A.3	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
GDHHQS2_k127_4740011_0	517418.Ctha_1398	1.468e-93	320.0	COG0543@1|root,COG0543@2|Bacteria,1FDJ4@1090|Chlorobi	1090|Chlorobi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
GDHHQS2_k127_4740011_1	324925.Ppha_0493	2.722e-78	271.0	COG0493@1|root,COG0493@2|Bacteria,1FDAT@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
GDHHQS2_k127_474013_0	101510.RHA1_ro03250	1.24e-35	136.0	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4FYHB@85025|Nocardiaceae	201174|Actinobacteria	L	Protein involved in transcription factor activity, transposase activity, DNA transposition and regulation of transcription, DNA-dependent	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
GDHHQS2_k127_474013_1	526225.Gobs_3736	5.226e-27	117.0	2DQTX@1|root,32UPT@2|Bacteria,2ID1B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_474013_2	710685.MycrhN_4897	8.684e-11	67.0	COG3794@1|root,COG3794@2|Bacteria,2GS7W@201174|Actinobacteria,23AYF@1762|Mycobacteriaceae	201174|Actinobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
GDHHQS2_k127_4767641_4	1411123.JQNH01000001_gene2727	6.681e-09	57.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	TPP_enzyme_C
GDHHQS2_k127_4767641_5	84531.JMTZ01000030_gene191	7.189e-08	63.0	2F6ZJ@1|root,33ZFG@2|Bacteria,1QFVX@1224|Proteobacteria,1TD6N@1236|Gammaproteobacteria,1XA8A@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4767641_0	1394178.AWOO02000037_gene9165	2.562e-78	275.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4EJ4T@85012|Streptosporangiales	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
GDHHQS2_k127_4767641_1	502025.Hoch_5296	2.701e-60	218.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS2_k127_4767641_3	1192034.CAP_0064	5.23e-16	87.0	COG2304@1|root,COG2304@2|Bacteria,1N4IM@1224|Proteobacteria,437ZC@68525|delta/epsilon subdivisions,2WZWU@28221|Deltaproteobacteria,2YUXT@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA
GDHHQS2_k127_4772804_0	525904.Tter_2275	8.193e-110	364.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
GDHHQS2_k127_4772804_1	525904.Tter_2276	1.289e-52	200.0	COG1721@1|root,COG1721@2|Bacteria,2NR5R@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
GDHHQS2_k127_4773533_2	1323361.JPOC01000088_gene1331	1.112e-14	84.0	COG2968@1|root,COG2968@2|Bacteria,2GM1U@201174|Actinobacteria,4FYJH@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF541)	lpqG	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
GDHHQS2_k127_4773533_0	526225.Gobs_2231	6.651e-122	407.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4ERQ1@85013|Frankiales	201174|Actinobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	Amacr	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
GDHHQS2_k127_4773533_1	570268.ANBB01000025_gene5661	3.094e-31	132.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4EG9Z@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS2_k127_4786449_2	300852.55772486	5.194e-51	190.0	COG0077@1|root,COG0077@2|Bacteria,1WIGR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
GDHHQS2_k127_4786449_5	318464.IO99_18365	5.188e-05	48.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
GDHHQS2_k127_4786449_3	1313172.YM304_38150	2.927e-29	119.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4CN8E@84992|Acidimicrobiia	84992|Acidimicrobiia	S	ATP-dependent Clp protease adaptor protein ClpS	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
GDHHQS2_k127_4786449_4	469371.Tbis_0935	2.168e-05	55.0	2E4AX@1|root,32Z6K@2|Bacteria,2GW4T@201174|Actinobacteria,4E31H@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
GDHHQS2_k127_4786449_0	309801.trd_0216	4.381e-72	258.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi,27XG5@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
GDHHQS2_k127_4786449_1	1120950.KB892803_gene1450	1.083e-54	196.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4DP8M@85009|Propionibacteriales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
GDHHQS2_k127_4788151_3	1038922.PflQ2_0123	6.222e-05	50.0	COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria,1YQS9@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
GDHHQS2_k127_4788151_0	1122609.AUGT01000017_gene824	6.249e-52	196.0	COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4DP2U@85009|Propionibacteriales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS2_k127_4788151_1	1151122.AQYD01000007_gene425	1.391e-40	155.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_4788151_2	1489678.RDMS_09970	2.506e-27	112.0	COG1132@1|root,COG1132@2|Bacteria,1WISJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS2_k127_4804819_0	710111.FraQA3DRAFT_1911	4.317e-55	203.0	COG3832@1|root,COG3832@2|Bacteria,2I8ND@201174|Actinobacteria,4EVF3@85013|Frankiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_4804819_1	590998.Celf_3583	9.574e-31	124.0	COG0640@1|root,COG0640@2|Bacteria,2IQ55@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GDHHQS2_k127_4804819_2	1121033.AUCF01000020_gene705	3.747e-25	121.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TVYB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	pdhS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9
GDHHQS2_k127_4816324_1	861299.J421_2864	3.553e-84	295.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
GDHHQS2_k127_4816324_0	1120973.AQXL01000135_gene1394	5.158e-129	425.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,4HAIS@91061|Bacilli,27884@186823|Alicyclobacillaceae	91061|Bacilli	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
GDHHQS2_k127_4816324_2	298655.KI912266_gene211	1.351e-49	180.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4ERRC@85013|Frankiales	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
GDHHQS2_k127_4824370_0	1463821.JOGR01000011_gene2076	3.13e-119	398.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4EXVQ@85014|Glycomycetales	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
GDHHQS2_k127_4824370_1	555079.Toce_0060	1.086e-36	141.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,42GS3@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
GDHHQS2_k127_4824370_2	1246484.D479_19733	1.951e-09	62.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,1V4B9@1239|Firmicutes,4HGZ9@91061|Bacilli,3NEVJ@45667|Halobacillus	91061|Bacilli	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1,SPOR
GDHHQS2_k127_4833045_3	583355.Caka_3084	1.062e-06	55.0	2CBRY@1|root,33DAH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4833045_1	1095767.CAHD01000203_gene2335	8.293e-10	65.0	2E4ST@1|root,32ZM5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tad
GDHHQS2_k127_4833045_0	935839.JAGJ01000022_gene3504	1.759e-20	103.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4F47R@85017|Promicromonosporaceae	201174|Actinobacteria	NU	Type ii secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
GDHHQS2_k127_4833045_4	446471.Xcel_1032	1.627e-06	52.0	COG2064@1|root,COG2064@2|Bacteria,2GKMW@201174|Actinobacteria,4F3TZ@85017|Promicromonosporaceae	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
GDHHQS2_k127_483577_0	1442599.JAAN01000030_gene2110	1.647e-43	168.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1X32F@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
GDHHQS2_k127_483577_2	1380391.JIAS01000011_gene5469	1.443e-05	54.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg
GDHHQS2_k127_483577_1	1293054.HSACCH_00057	1.081e-18	85.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,3WAA0@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
GDHHQS2_k127_4837611_1	634497.HAH_5183	1.138e-13	72.0	COG2086@1|root,arCOG00446@2157|Archaea,2XW02@28890|Euryarchaeota,23TZ0@183963|Halobacteria	183963|Halobacteria	C	Electron transfer flavoprotein, beta subunit	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
GDHHQS2_k127_4837611_0	446470.Snas_1822	9.058e-146	469.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
GDHHQS2_k127_4838796_0	479431.Namu_1999	1.414e-74	260.0	COG1073@1|root,COG1073@2|Bacteria,2IPVI@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4838796_1	1125971.ASJB01000064_gene6508	6.751e-34	135.0	COG4635@1|root,COG4635@2|Bacteria,2IMZZ@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
GDHHQS2_k127_4839092_0	526226.Gbro_2224	7.567e-37	149.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4GAWZ@85026|Gordoniaceae	201174|Actinobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
GDHHQS2_k127_4841691_0	1382356.JQMP01000001_gene751	1.176e-94	327.0	COG1319@1|root,COG2080@1|root,COG1319@2|Bacteria,COG2080@2|Bacteria,2G5XD@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
GDHHQS2_k127_4841691_1	42256.RradSPS_2920	7.11e-47	171.0	COG0590@1|root,COG0590@2|Bacteria,2I9KR@201174|Actinobacteria	201174|Actinobacteria	FJ	CMP dCMP deaminase, zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
GDHHQS2_k127_4845122_4	744980.TRICHSKD4_5341	7.383e-49	179.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain	yitJ	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
GDHHQS2_k127_4845122_3	1463854.JOHT01000007_gene3354	1.965e-58	214.0	COG2113@1|root,COG2113@2|Bacteria,2GP39@201174|Actinobacteria	201174|Actinobacteria	E	glycine betaine transport	proX	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
GDHHQS2_k127_4845122_1	1245475.ANAE01000206_gene3966	1.389e-110	372.0	COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria,4EGWC@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
GDHHQS2_k127_4845122_0	1236902.ANAS01000005_gene4789	9.482e-114	392.0	COG4176@1|root,COG4176@2|Bacteria,2GKRF@201174|Actinobacteria,4EFZH@85012|Streptosporangiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	proW	-	-	ko:K02001	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
GDHHQS2_k127_4845122_2	1469607.KK073768_gene3681	1.493e-89	304.0	COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1HIHK@1161|Nostocales	1117|Cyanobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	ko:K12420	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06642,R09262,R09263,R09264	RC00029,RC00144	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	adh_short,adh_short_C2
GDHHQS2_k127_4845122_5	1463853.JOHW01000020_gene6825	2.874e-24	107.0	COG0640@1|root,COG0640@2|Bacteria,2IKWF@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GDHHQS2_k127_4846795_0	383372.Rcas_0843	9.254e-77	260.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi,3764A@32061|Chloroflexia	32061|Chloroflexia	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
GDHHQS2_k127_4846795_1	485913.Krac_10570	2.545e-71	253.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS2_k127_4850066_0	313589.JNB_09269	1.18e-54	198.0	COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4FIXC@85021|Intrasporangiaceae	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
GDHHQS2_k127_4850066_2	656024.FsymDg_0858	8.315e-21	98.0	COG1846@1|root,COG1846@2|Bacteria,2IJHQ@201174|Actinobacteria,4ET44@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
GDHHQS2_k127_4850066_1	266117.Rxyl_0142	4.846e-39	151.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4CQIW@84995|Rubrobacteria	84995|Rubrobacteria	O	OsmC-like protein	-	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
GDHHQS2_k127_4850066_3	65497.JODV01000006_gene719	4.328e-05	51.0	COG0346@1|root,COG0346@2|Bacteria,2IHZH@201174|Actinobacteria,4E4CC@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	gloA	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_4859590_0	552811.Dehly_1466	9.199e-105	353.0	COG0003@1|root,COG0003@2|Bacteria,2G64V@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
GDHHQS2_k127_4864761_1	1283299.AUKG01000001_gene2920	1.267e-18	97.0	COG0789@1|root,COG2114@1|root,COG0789@2|Bacteria,COG2114@2|Bacteria,2ICT6@201174|Actinobacteria,4CR4V@84995|Rubrobacteria	84995|Rubrobacteria	KT	Adenylate cyclase regulatory domain	-	-	-	-	-	-	-	-	-	-	-	-	Ad_Cy_reg,Guanylate_cyc,MerR_1
GDHHQS2_k127_4864761_0	1003195.SCAT_3332	1.797e-31	126.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
GDHHQS2_k127_487183_3	290397.Adeh_2425	2.566e-52	203.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2Z0ZI@29|Myxococcales	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
GDHHQS2_k127_487183_2	644966.Tmar_0523	3.357e-70	244.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia	186801|Clostridia	E	Abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS2_k127_487183_4	1038860.AXAP01000017_gene2910	7.808e-45	171.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2TTG6@28211|Alphaproteobacteria,3JUVS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS2_k127_487183_1	1125971.ASJB01000022_gene6860	1.144e-112	375.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,4DZEJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
GDHHQS2_k127_487183_0	1449976.KALB_2033	1.712e-173	559.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZ4K@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
GDHHQS2_k127_4873167_2	1242864.D187_002504	7.308e-25	107.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria	1224|Proteobacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS2_k127_4873167_0	1121924.ATWH01000022_gene3201	2.264e-79	276.0	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria,4FPYP@85023|Microbacteriaceae	201174|Actinobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
GDHHQS2_k127_4873167_1	671143.DAMO_0156	2.711e-71	254.0	COG0028@1|root,COG0028@2|Bacteria,2NNMW@2323|unclassified Bacteria	2|Bacteria	EH	thiamine pyrophosphate protein TPP binding domain protein	ilvB1	-	2.2.1.6,4.1.1.75	ko:K01652,ko:K12253	ko00290,ko00330,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00330,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R03178,R04672,R04673,R08648	RC00027,RC00106,RC00506,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
GDHHQS2_k127_4876332_1	440512.C211_05426	6.162e-46	170.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
GDHHQS2_k127_4876332_0	436229.JOEH01000043_gene577	3.229e-166	533.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,2NGNI@228398|Streptacidiphilus	201174|Actinobacteria	G	Nucleotidyl transferase	glgC	GO:0000271,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
GDHHQS2_k127_4876332_2	525368.HMPREF0591_4215	1.671e-19	92.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,23324@1762|Mycobacteriaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX_1	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
GDHHQS2_k127_4879536_0	1120950.KB892801_gene1759	3.907e-82	280.0	COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,2GMWU@201174|Actinobacteria,4DTYB@85009|Propionibacteriales	201174|Actinobacteria	K	IrrE N-terminal-like domain	hipB	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,Peptidase_M78
GDHHQS2_k127_4879536_2	1206739.BAGJ01000271_gene4869	3.336e-24	108.0	COG3576@1|root,COG3576@2|Bacteria,2I3R7@201174|Actinobacteria,4G1T9@85025|Nocardiaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
GDHHQS2_k127_4879536_1	1123502.AQXD01000001_gene849	1.119e-57	213.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1X3PC@135614|Xanthomonadales	135614|Xanthomonadales	C	acetyltransferase component of pyruvate dehydrogenase complex	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
GDHHQS2_k127_4889188_0	562970.Btus_0433	8.356e-174	572.0	COG0843@1|root,COG0843@2|Bacteria,1TP2U@1239|Firmicutes,4HA4X@91061|Bacilli,2782I@186823|Alicyclobacillaceae	91061|Bacilli	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.10.3.12,1.9.3.1	ko:K02274,ko:K02827	ko00190,ko01100,map00190,map01100	M00155,M00416	R00081,R09492	RC00016,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
GDHHQS2_k127_4889188_1	1382306.JNIM01000001_gene4037	4.902e-76	265.0	COG1622@1|root,COG1622@2|Bacteria,2G6C0@200795|Chloroflexi	200795|Chloroflexi	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
GDHHQS2_k127_4892628_1	1123065.ATWL01000001_gene471	4.009e-72	251.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
GDHHQS2_k127_4892628_2	1121877.JQKF01000002_gene1620	7.037e-11	64.0	2E9C2@1|root,333JS@2|Bacteria,2HGHP@201174|Actinobacteria,4CNEV@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	-	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
GDHHQS2_k127_4892628_0	35754.JNYJ01000034_gene2114	5.525e-149	484.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4D9VI@85008|Micromonosporales	201174|Actinobacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
GDHHQS2_k127_4901946_0	324602.Caur_1378	1.285e-182	588.0	COG0439@1|root,COG0439@2|Bacteria,2G62X@200795|Chloroflexi,3780X@32061|Chloroflexia	32061|Chloroflexia	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
GDHHQS2_k127_4901946_1	1211815.CBYP010000016_gene2617	1.535e-51	199.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4ERQA@85013|Frankiales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4905858_1	479433.Caci_6732	5.156e-05	53.0	COG1653@1|root,COG1653@2|Bacteria,2GJYT@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
GDHHQS2_k127_4905858_0	103690.17130404	2.163e-110	370.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1HIEI@1161|Nostocales	1117|Cyanobacteria	G	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
GDHHQS2_k127_4911757_2	525903.Taci_0661	0.0006697	45.0	COG1040@1|root,COG1040@2|Bacteria,3TBEA@508458|Synergistetes	508458|Synergistetes	S	PFAM Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
GDHHQS2_k127_4911757_0	648996.Theam_1249	4.109e-159	511.0	COG0499@1|root,COG0499@2|Bacteria,2G3TI@200783|Aquificae	200783|Aquificae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
GDHHQS2_k127_4911757_1	929712.KI912613_gene2888	1.791e-32	132.0	COG2222@1|root,COG2222@2|Bacteria,2IN5A@201174|Actinobacteria,4CP71@84995|Rubrobacteria	84995|Rubrobacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
GDHHQS2_k127_49159_3	985665.HPL003_06035	4.774e-08	55.0	COG0402@1|root,COG0402@2|Bacteria,1VTFK@1239|Firmicutes,4HTWB@91061|Bacilli,26V47@186822|Paenibacillaceae	91061|Bacilli	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_49159_0	1463917.JODC01000007_gene7463	1.984e-114	376.0	COG0662@1|root,COG0662@2|Bacteria,2GN99@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_49159_1	285535.JOEY01000011_gene6150	4.982e-81	275.0	COG1028@1|root,COG1028@2|Bacteria,2I6UQ@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
GDHHQS2_k127_49159_2	1297569.MESS2_60004	1.676e-36	145.0	COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2TTHH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	LacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
GDHHQS2_k127_4917988_0	889378.Spiaf_2411	4.073e-113	377.0	COG0667@1|root,COG0667@2|Bacteria,2JBDE@203691|Spirochaetes	203691|Spirochaetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS2_k127_4925680_2	1235835.C814_01052	7.002e-52	193.0	COG2421@1|root,COG2421@2|Bacteria,1TQ67@1239|Firmicutes,24AKC@186801|Clostridia	186801|Clostridia	C	Acetamidase formamidase	-	-	3.5.1.49	ko:K01455	ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200	-	R00524	RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
GDHHQS2_k127_4925680_3	382245.ASA_3109	4.493e-14	79.0	COG3695@1|root,COG3695@2|Bacteria,1N7J2@1224|Proteobacteria,1SCIZ@1236|Gammaproteobacteria,1Y4X0@135624|Aeromonadales	135624|Aeromonadales	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
GDHHQS2_k127_4925680_1	1227268.HMPREF1552_01100	1.98e-60	215.0	COG0035@1|root,COG0035@2|Bacteria,378U5@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
GDHHQS2_k127_4925680_0	1313172.YM304_00150	9.544e-153	494.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CNGZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
GDHHQS2_k127_4951214_2	1380390.JIAT01000011_gene2492	1.659e-20	93.0	COG0262@1|root,COG0262@2|Bacteria,2GJU5@201174|Actinobacteria	201174|Actinobacteria	H	Bifunctional deaminase-reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
GDHHQS2_k127_4951214_1	222534.KB893727_gene5414	1.592e-22	107.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_4951214_0	345341.KUTG_00976	7.184e-109	373.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DYN9@85010|Pseudonocardiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
GDHHQS2_k127_4957304_0	1089550.ATTH01000001_gene1294	9.92e-187	597.0	COG0366@1|root,COG0366@2|Bacteria,4NFE4@976|Bacteroidetes	976|Bacteroidetes	G	Alpha amylase catalytic	-	-	3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,DUF3459,Malt_amylase_C
GDHHQS2_k127_4957304_1	604331.AUHY01000037_gene54	3.625e-23	109.0	COG0134@1|root,COG0134@2|Bacteria,1WI5W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
GDHHQS2_k127_4960073_0	485913.Krac_2637	4.806e-152	494.0	COG2208@1|root,COG2208@2|Bacteria,2G790@200795|Chloroflexi	200795|Chloroflexi	T	Stage II sporulation E family protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
GDHHQS2_k127_4960073_4	485913.Krac_2638	8.199e-25	108.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
GDHHQS2_k127_4960073_3	1177594.MIC448_2190008	3.564e-30	127.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K03090,ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
GDHHQS2_k127_4960073_2	710685.MycrhN_3037	9.062e-52	193.0	arCOG02771@1|root,2Z8A4@2|Bacteria,2GNG0@201174|Actinobacteria,23FGV@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_4964940_1	1082931.KKY_2907	2.641e-23	108.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2TVQD@28211|Alphaproteobacteria,3N6TE@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	peptidyl-prolyl isomerase	ppiC	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
GDHHQS2_k127_4964940_0	698769.JFBD01000043_gene616	1.383e-27	121.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,4C4XE@84406|Virgibacillus	91061|Bacilli	S	Tetrapyrrole (Corrin/Porphyrin) Methylases	yabN	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
GDHHQS2_k127_4966951_1	521674.Plim_2032	1.18e-55	199.0	COG0505@1|root,COG0505@2|Bacteria,2IWSY@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
GDHHQS2_k127_4966951_0	1229780.BN381_50144	0.0	1267.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,3UW8D@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
GDHHQS2_k127_4966951_2	592028.GCWU000321_00022	1.417e-29	129.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,4H2MP@909932|Negativicutes	909932|Negativicutes	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
GDHHQS2_k127_4972466_1	2074.JNYD01000004_gene4948	5.284e-80	271.0	COG1653@1|root,COG1653@2|Bacteria,2IDWS@201174|Actinobacteria,4E16T@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
GDHHQS2_k127_4972466_0	1038860.AXAP01000106_gene4263	1.05e-125	415.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3JQYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
GDHHQS2_k127_4979209_0	1043205.AFYF01000030_gene503	6.175e-157	504.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,2GNCW@201174|Actinobacteria,4FENX@85021|Intrasporangiaceae	201174|Actinobacteria	E	Belongs to the GcvT family	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
GDHHQS2_k127_4979209_1	717605.Theco_3934	1.396e-14	79.0	COG0667@1|root,COG0667@2|Bacteria,1UKPC@1239|Firmicutes,4HCF8@91061|Bacilli,27516@186822|Paenibacillaceae	91061|Bacilli	C	Aldo/keto reductase family	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
GDHHQS2_k127_4982861_2	196627.cg2158	1.289e-76	263.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,22JQ0@1653|Corynebacteriaceae	201174|Actinobacteria	D	DNA segregation ATPase FtsK SpoIIIE and related proteins	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
GDHHQS2_k127_4982861_1	867903.ThesuDRAFT_01196	2.056e-95	323.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia	186801|Clostridia	C	dehydrogenase, E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
GDHHQS2_k127_4982861_0	1227488.C477_05736	7.615e-97	322.0	COG0022@1|root,arCOG01052@2157|Archaea,2XT3K@28890|Euryarchaeota,23SKR@183963|Halobacteria	183963|Halobacteria	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	oxdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
GDHHQS2_k127_4985943_5	1122223.KB890687_gene2936	1.466e-14	81.0	COG0015@1|root,COG0015@2|Bacteria,1WMD3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Adenylosuccinate lyase C-terminus	-	-	5.5.1.2	ko:K01857	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03307	RC00902	ko00000,ko00001,ko01000	-	-	-	Lyase_1
GDHHQS2_k127_4985943_3	1217718.ALOU01000013_gene289	7.435e-51	186.0	COG3485@1|root,COG3485@2|Bacteria,1MV3B@1224|Proteobacteria,2VQBG@28216|Betaproteobacteria,1K4S5@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	protocatechuate 3,4-dioxygenase	pcaG	-	1.13.11.3	ko:K00448	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
GDHHQS2_k127_4985943_2	1120956.JHZK01000009_gene1676	2.953e-81	277.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2TU2C@28211|Alphaproteobacteria,1JNUR@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Protocatechuate 3,4-dioxygenase beta subunit N terminal	pcaH	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C,PCDO_beta_N
GDHHQS2_k127_4985943_4	1123366.TH3_05410	2.228e-39	152.0	COG0599@1|root,COG0599@2|Bacteria,1RDSG@1224|Proteobacteria,2U72V@28211|Alphaproteobacteria,2JTJ6@204441|Rhodospirillales	204441|Rhodospirillales	S	Carboxymuconolactone decarboxylase family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
GDHHQS2_k127_4985943_0	670292.JH26_01420	9.588e-143	464.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,1JRXV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CH	TIGRFAM 4-hydroxybenzoate 3-monooxygenase	pobA	GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
GDHHQS2_k127_4985943_1	446470.Snas_2328	7.65e-103	338.0	COG1788@1|root,COG1788@2|Bacteria,2I9F6@201174|Actinobacteria	201174|Actinobacteria	I	Pfam Coenzyme A transferase	gctA	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
GDHHQS2_k127_498747_1	1403819.BATR01000164_gene5524	2.42e-45	169.0	COG0454@1|root,COG0456@2|Bacteria,46SWZ@74201|Verrucomicrobia,2IVZ7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_498747_0	1313172.YM304_04120	3.044e-178	582.0	COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,4CMPH@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
GDHHQS2_k127_5007610_0	521045.Kole_0242	1.08e-192	626.0	COG0058@1|root,COG0058@2|Bacteria,2GCCY@200918|Thermotogae	200918|Thermotogae	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
GDHHQS2_k127_5007610_1	1121877.JQKF01000003_gene1462	4.652e-40	168.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CMQ6@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
GDHHQS2_k127_5020315_5	883169.HMPREF9719_01536	6.162e-46	170.0	COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,22JW0@1653|Corynebacteriaceae	201174|Actinobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
GDHHQS2_k127_5020315_9	1396141.BATP01000039_gene1415	1.304e-32	133.0	COG0256@1|root,COG0256@2|Bacteria,46T7Z@74201|Verrucomicrobia,2IUJF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
GDHHQS2_k127_5020315_2	1235794.C811_00995	6.991e-68	239.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4CVIK@84998|Coriobacteriia	84998|Coriobacteriia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
GDHHQS2_k127_5020315_6	1504319.GM45_2580	4.687e-42	157.0	COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,3UWN2@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
GDHHQS2_k127_5020315_13	1229780.BN381_450084	4.403e-22	100.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,3UXRU@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Ribosomal protein S14p/S29e	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
GDHHQS2_k127_5020315_1	1158318.ATXC01000001_gene1262	1.387e-74	257.0	COG0094@1|root,COG0094@2|Bacteria,2G3N4@200783|Aquificae	200783|Aquificae	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
GDHHQS2_k127_5020315_11	1304284.L21TH_0903	8.322e-25	114.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,36JMF@31979|Clostridiaceae	186801|Clostridia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
GDHHQS2_k127_5020315_4	1504319.GM45_2600	4.911e-57	202.0	COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,3UWIV@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
GDHHQS2_k127_5020315_10	643648.Slip_2228	2.851e-25	108.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42K48@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
GDHHQS2_k127_5020315_14	649764.HMPREF0762_01826	2.364e-16	81.0	COG0255@1|root,COG0255@2|Bacteria,2IQ6V@201174|Actinobacteria,4CWMP@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
GDHHQS2_k127_5020315_3	926561.KB900620_gene3194	6.696e-63	218.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3WAKN@53433|Halanaerobiales	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
GDHHQS2_k127_5020315_0	1032480.MLP_11040	2.157e-78	277.0	COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4DNUB@85009|Propionibacteriales	201174|Actinobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
GDHHQS2_k127_5020315_8	1196029.ALIM01000033_gene1526	2.257e-34	135.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,4HIK2@91061|Bacilli,1ZG6U@1386|Bacillus	91061|Bacilli	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
GDHHQS2_k127_5020315_7	865861.AZSU01000001_gene25	3.841e-41	153.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,36JHK@31979|Clostridiaceae	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
GDHHQS2_k127_5020315_12	1410634.JHVD01000010_gene2413	1.919e-22	96.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4DN2A@85009|Propionibacteriales	201174|Actinobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
GDHHQS2_k127_5021375_1	1342299.Z947_120	7.706e-42	157.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
GDHHQS2_k127_5021375_0	1463857.JOFZ01000001_gene5441	3.586e-66	237.0	COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria	201174|Actinobacteria	CH	amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
GDHHQS2_k127_5028744_0	656024.FsymDg_1041	2.836e-69	237.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4ES23@85013|Frankiales	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
GDHHQS2_k127_5028744_1	794846.AJQU01000023_gene5140	1.445e-11	74.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,4B737@82115|Rhizobiaceae	28211|Alphaproteobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS2_k127_5035583_0	316274.Haur_2760	9.081e-88	298.0	COG0834@1|root,COG0834@2|Bacteria,2G6HE@200795|Chloroflexi,376SS@32061|Chloroflexia	32061|Chloroflexia	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
GDHHQS2_k127_5036445_1	446466.Cfla_3072	3.241e-30	123.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class v	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
GDHHQS2_k127_5036445_0	497964.CfE428DRAFT_0631	2.474e-106	359.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
GDHHQS2_k127_5069521_0	926550.CLDAP_07090	2.303e-107	361.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
GDHHQS2_k127_5069521_1	215803.DB30_7934	2.198e-07	55.0	COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,43BB7@68525|delta/epsilon subdivisions,2X6QD@28221|Deltaproteobacteria,2Z3C9@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
GDHHQS2_k127_5070456_3	1229780.BN381_80377	7.062e-109	366.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,3UXSE@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nuoF_1	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S
GDHHQS2_k127_5070456_1	545695.TREAZ_1389	1.028e-226	717.0	COG2759@1|root,COG2759@2|Bacteria,2J5JZ@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
GDHHQS2_k127_5070456_7	1313172.YM304_35680	8.855e-31	136.0	COG1414@1|root,COG1414@2|Bacteria,2HGKJ@201174|Actinobacteria,4CNIR@84992|Acidimicrobiia	84992|Acidimicrobiia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
GDHHQS2_k127_5070456_5	1089546.AQUI01000002_gene1870	2.059e-68	242.0	COG0685@1|root,COG0685@2|Bacteria,2I92A@201174|Actinobacteria,408NF@622450|Actinopolysporales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
GDHHQS2_k127_5070456_2	748247.AZKH_p0144	2.035e-217	686.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria	1224|Proteobacteria	H	trimethylamine methyltransferase	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
GDHHQS2_k127_5070456_4	134676.ACPL_2014	1.087e-90	307.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4DEP9@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
GDHHQS2_k127_5070456_0	1380391.JIAS01000001_gene2815	1.256e-253	801.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
GDHHQS2_k127_5070456_6	1469245.JFBG01000006_gene1587	2.218e-52	187.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RZF4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG1410 Methionine synthase I cobalamin-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_bind
GDHHQS2_k127_5077046_4	1121272.KB903251_gene626	1.057e-16	83.0	2BW4Y@1|root,346D2@2|Bacteria,2GTRH@201174|Actinobacteria,4DKHV@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
GDHHQS2_k127_5077046_0	1100720.ALKN01000007_gene3006	8.23e-120	394.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2VI56@28216|Betaproteobacteria,4AB7B@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism	add	-	3.5.4.2,3.5.4.4	ko:K01488,ko:K21053	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01244,R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
GDHHQS2_k127_5077046_2	1297742.A176_03906	1.396e-23	113.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1MVRR@1224|Proteobacteria,42NSC@68525|delta/epsilon subdivisions,2WMAX@28221|Deltaproteobacteria,2YUKT@29|Myxococcales	28221|Deltaproteobacteria	CE	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
GDHHQS2_k127_5077046_1	926569.ANT_14510	1.654e-75	261.0	COG1529@1|root,COG1529@2|Bacteria,2G5PH@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS2_k127_5084742_2	1223544.GSI01S_06_00680	3.952e-19	97.0	2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria,4GAMP@85026|Gordoniaceae	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
GDHHQS2_k127_5084742_0	935567.JAES01000022_gene2437	1.468e-84	292.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1X3S9@135614|Xanthomonadales	135614|Xanthomonadales	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
GDHHQS2_k127_5084742_1	518766.Rmar_1220	3.319e-25	109.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.269	ko:K18818	ko00051,map00051	-	R09666	RC00005,RC00397	ko00000,ko00001,ko01000	-	GT78	-	-
GDHHQS2_k127_5085831_0	246197.MXAN_3252	1.314e-21	100.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,2YVYE@29|Myxococcales	28221|Deltaproteobacteria	CO	Redoxin	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
GDHHQS2_k127_5085831_1	1408444.JHYC01000002_gene597	7.26e-06	56.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1JC9C@118969|Legionellales	118969|Legionellales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
GDHHQS2_k127_5119809_2	469383.Cwoe_1648	2.054e-10	70.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
GDHHQS2_k127_5119809_0	479431.Namu_2452	1.716e-25	112.0	COG1983@1|root,COG1983@2|Bacteria,2GWIA@201174|Actinobacteria	201174|Actinobacteria	KT	Phage shock protein C (PspC)	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
GDHHQS2_k127_5119809_1	298655.KI912266_gene6084	4.15e-12	70.0	COG5401@1|root,COG5401@2|Bacteria,2H4HT@201174|Actinobacteria	201174|Actinobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad2
GDHHQS2_k127_5124280_1	685727.REQ_35070	4.739e-09	63.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4G3HR@85025|Nocardiaceae	201174|Actinobacteria	P	Rieske-like [2Fe-2S] domain	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
GDHHQS2_k127_5124280_0	309801.trd_0379	1.138e-53	204.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi,27Y27@189775|Thermomicrobia	189775|Thermomicrobia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
GDHHQS2_k127_5128382_1	1089544.KB912942_gene6869	2.422e-42	168.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4E064@85010|Pseudonocardiales	201174|Actinobacteria	D	PFAM Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
GDHHQS2_k127_5128382_0	1313172.YM304_33000	4.348e-74	257.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4CN1K@84992|Acidimicrobiia	84992|Acidimicrobiia	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
GDHHQS2_k127_5128940_1	1082933.MEA186_09605	1.057e-64	229.0	COG2346@1|root,COG2346@2|Bacteria,1Q38S@1224|Proteobacteria,2UJT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
GDHHQS2_k127_5128940_0	867845.KI911784_gene290	7.212e-94	334.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,2GABV@200795|Chloroflexi,3752H@32061|Chloroflexia	32061|Chloroflexia	M	Cna B domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,SdrD_B
GDHHQS2_k127_5132263_0	443598.AUFA01000015_gene6818	1.464e-125	415.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,3JTIE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
GDHHQS2_k127_5132263_1	411684.HPDFL43_20842	4.417e-17	88.0	COG1898@1|root,COG1898@2|Bacteria,1RDAB@1224|Proteobacteria,2U99D@28211|Alphaproteobacteria,43PVP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	dTDP-4-dehydrorhamnose 3,5-epimerase	rfbC	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008830,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
GDHHQS2_k127_5134253_1	1121382.JQKG01000024_gene1554	1.991e-83	286.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
GDHHQS2_k127_5134253_0	1193181.BN10_650046	1.634e-127	421.0	COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4FFV2@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
GDHHQS2_k127_5134253_2	933115.GPDM_06795	6.807e-07	54.0	COG0572@1|root,COG0572@2|Bacteria,1V8GA@1239|Firmicutes,4HINJ@91061|Bacilli	91061|Bacilli	F	uridine kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,PRK
GDHHQS2_k127_5138645_2	177437.HRM2_38480	1.912e-51	193.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	sarcosine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
GDHHQS2_k127_5138645_3	1207063.P24_08589	1.023e-17	84.0	COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria,2JTNT@204441|Rhodospirillales	204441|Rhodospirillales	E	Sarcosine oxidase, delta subunit family	-	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
GDHHQS2_k127_5138645_0	1123023.JIAI01000007_gene1965	3.543e-118	394.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,4EEMB@85010|Pseudonocardiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
GDHHQS2_k127_5138645_1	1218084.BBJK01000021_gene2266	9.645e-58	211.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2VK5U@28216|Betaproteobacteria,1KD3N@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Sarcosine oxidase, gamma subunit family	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
GDHHQS2_k127_5145036_1	1122609.AUGT01000009_gene3171	5.329e-27	112.0	2DHIP@1|root,2ZZZ7@2|Bacteria,2HEZZ@201174|Actinobacteria,4DSWE@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5145036_0	526225.Gobs_1791	2.379e-65	232.0	COG0702@1|root,COG0702@2|Bacteria,2ICEY@201174|Actinobacteria	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
GDHHQS2_k127_5147703_1	1313172.YM304_08960	1.018e-81	280.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4CMUH@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
GDHHQS2_k127_5147703_2	446469.Sked_28700	1.802e-36	141.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
GDHHQS2_k127_5147703_0	1074488.AGBX01000003_gene135	3.487e-93	309.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4FBDW@85020|Dermabacteraceae	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
GDHHQS2_k127_5161664_1	882083.SacmaDRAFT_5378	1.822e-96	327.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4DZTM@85010|Pseudonocardiales	201174|Actinobacteria	I	Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	6.4.1.3,6.4.1.4	ko:K01965,ko:K01968	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00036,M00373,M00741	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
GDHHQS2_k127_5161664_3	1128421.JAGA01000003_gene3280	5.384e-29	124.0	2AZDP@1|root,31RMA@2|Bacteria,2NRKB@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
GDHHQS2_k127_5161664_0	1128421.JAGA01000002_gene1889	3.749e-105	349.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	glxR	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	iJN678.mmsB	NAD_binding_11,NAD_binding_2
GDHHQS2_k127_5161664_2	656024.FsymDg_2082	1.41e-68	246.0	28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria,4ESGD@85013|Frankiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,Wyosine_form
GDHHQS2_k127_517564_0	1521187.JPIM01000016_gene3672	1.926e-68	245.0	COG1804@1|root,COG1804@2|Bacteria,2G7MX@200795|Chloroflexi,3751U@32061|Chloroflexia	32061|Chloroflexia	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
GDHHQS2_k127_517564_2	639283.Snov_0187	2.557e-54	208.0	COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS2_k127_517564_1	1108045.GORHZ_183_00210	2.19e-55	207.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4GDPY@85026|Gordoniaceae	201174|Actinobacteria	H	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
GDHHQS2_k127_5182472_0	1380390.JIAT01000010_gene3567	1.923e-195	640.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
GDHHQS2_k127_5184146_0	63737.Npun_R6427	6.053e-90	299.0	COG2873@1|root,COG2873@2|Bacteria,1G4EH@1117|Cyanobacteria,1HINV@1161|Nostocales	1117|Cyanobacteria	E	Cys/Met metabolism PLP-dependent enzyme	met17	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
GDHHQS2_k127_5184146_1	65093.PCC7418_0605	2.458e-58	209.0	COG2021@1|root,COG2021@2|Bacteria,1G4G5@1117|Cyanobacteria	1117|Cyanobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
GDHHQS2_k127_520111_2	309799.DICTH_1305	2.799e-25	109.0	COG1544@1|root,COG1544@2|Bacteria	2|Bacteria	J	regulation of translation	raiA	-	-	ko:K03733,ko:K05808,ko:K05809	-	-	-	-	ko00000,ko03009,ko03036	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
GDHHQS2_k127_520111_1	298654.FraEuI1c_6044	5.039e-46	173.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4ERMX@85013|Frankiales	201174|Actinobacteria	K	Response regulator receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
GDHHQS2_k127_520111_0	405948.SACE_6442	5.003e-171	545.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4DXEF@85010|Pseudonocardiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
GDHHQS2_k127_5218228_2	134676.ACPL_2668	1.39e-35	145.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria,4DATE@85008|Micromonosporales	201174|Actinobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve
GDHHQS2_k127_5218228_0	43759.JNWK01000065_gene4065	1.79e-81	278.0	COG2801@1|root,COG2801@2|Bacteria,2GJ3V@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	LZ_Tnp_IS481,rve,rve_3
GDHHQS2_k127_5218228_3	979556.MTES_3674	1.506e-24	119.0	COG5002@1|root,COG5002@2|Bacteria,2HGIV@201174|Actinobacteria,4FNAV@85023|Microbacteriaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
GDHHQS2_k127_5218228_1	697282.Mettu_3064	5.366e-58	210.0	COG0156@1|root,COG0156@2|Bacteria,1R0M1@1224|Proteobacteria,1S12P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
GDHHQS2_k127_5222038_2	449447.MAE_01140	4.635e-56	212.0	COG0391@1|root,COG0391@2|Bacteria,1G0R0@1117|Cyanobacteria	1117|Cyanobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
GDHHQS2_k127_5222038_1	1236902.ANAS01000040_gene5025	3.834e-80	276.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4EGVC@85012|Streptosporangiales	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
GDHHQS2_k127_5222038_0	1229780.BN381_50096	2.999e-92	310.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,3UWEG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
GDHHQS2_k127_5236327_1	298655.KI912266_gene5225	2.264e-42	159.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,4ET2V@85013|Frankiales	201174|Actinobacteria	Q	PFAM isochorismatase hydrolase	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
GDHHQS2_k127_5236327_0	926550.CLDAP_31050	1.093e-184	592.0	COG1488@1|root,COG1488@2|Bacteria,2G70D@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	-
GDHHQS2_k127_5236327_3	1206725.BAFU01000072_gene6312	0.0007869	50.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4FV4C@85025|Nocardiaceae	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
GDHHQS2_k127_5236327_2	1160718.SU9_10933	0.0004405	51.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria	201174|Actinobacteria	KT	PspC domain protein	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
GDHHQS2_k127_5244708_2	644282.Deba_2661	3.212e-34	140.0	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,42VFB@68525|delta/epsilon subdivisions,2WRRQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
GDHHQS2_k127_5244708_4	932678.THERU_00150	2.243e-14	78.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
GDHHQS2_k127_5244708_0	1125863.JAFN01000001_gene198	4.085e-113	375.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EJ	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
GDHHQS2_k127_5244708_3	1125971.ASJB01000063_gene4122	1.394e-30	128.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4E45R@85010|Pseudonocardiales	201174|Actinobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
GDHHQS2_k127_5244708_1	1172188.KB911820_gene2341	6.991e-59	209.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4FGDH@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
GDHHQS2_k127_5246609_1	326427.Cagg_2524	2.185e-18	96.0	COG1668@1|root,COG1668@2|Bacteria,2GBIJ@200795|Chloroflexi,3768Z@32061|Chloroflexia	32061|Chloroflexia	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_3
GDHHQS2_k127_5246609_0	765420.OSCT_0421	2.049e-86	296.0	COG1131@1|root,COG1131@2|Bacteria,2GAQH@200795|Chloroflexi,3753M@32061|Chloroflexia	32061|Chloroflexia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS2_k127_5246609_2	1033743.CAES01000014_gene2400	8.023e-10	72.0	COG0318@1|root,COG0318@2|Bacteria,1V2NE@1239|Firmicutes,4HBPA@91061|Bacilli,26T64@186822|Paenibacillaceae	91061|Bacilli	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5247197_0	1121930.AQXG01000006_gene798	2.597e-202	651.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,4NFPE@976|Bacteroidetes,1IR1P@117747|Sphingobacteriia	976|Bacteroidetes	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
GDHHQS2_k127_5247197_2	402881.Plav_2811	1.866e-108	359.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,1JPTD@119043|Rhodobiaceae	28211|Alphaproteobacteria	GK	ROK family	-	-	2.7.1.2,2.7.1.4	ko:K00845,ko:K00847	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
GDHHQS2_k127_5247197_6	1223544.GSI01S_40_00010	2.158e-25	119.0	COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4GARF@85026|Gordoniaceae	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	lytR2	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
GDHHQS2_k127_5247197_7	546414.Deide_02060	9.189e-23	102.0	COG2050@1|root,COG2050@2|Bacteria,1WK2I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	phenylacetic acid degradation protein PaaD	-	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
GDHHQS2_k127_5247197_5	1229780.BN381_30035	2.735e-54	200.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,3UXJK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Peptidase C26	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,Methyltransf_11
GDHHQS2_k127_5247197_3	298653.Franean1_0202	4.467e-96	322.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4ERID@85013|Frankiales	201174|Actinobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
GDHHQS2_k127_5247197_8	272568.GDI1957	1.108e-15	79.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2JTEV@204441|Rhodospirillales	204441|Rhodospirillales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
GDHHQS2_k127_5247197_4	1229780.BN381_130016	3.292e-68	242.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,3UWG1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
GDHHQS2_k127_5247197_1	1229780.BN381_130019	1.979e-179	575.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,3UWF7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
GDHHQS2_k127_5259046_1	436229.JOEH01000002_gene3426	8.725e-56	207.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,2NESD@228398|Streptacidiphilus	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_5259046_0	1187851.A33M_0952	1.345e-100	336.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
GDHHQS2_k127_5269803_2	1385517.N800_00455	1.371e-18	99.0	COG1404@1|root,COG4447@1|root,COG1404@2|Bacteria,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria	1224|Proteobacteria	MU	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
GDHHQS2_k127_5269803_0	926560.KE387027_gene1021	1.138e-117	394.0	2DB7V@1|root,2Z7NX@2|Bacteria,1WM7S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5269803_1	999541.bgla_2g01110	1.272e-71	247.0	COG1028@1|root,COG1028@2|Bacteria,1PP5H@1224|Proteobacteria,2VJ4Y@28216|Betaproteobacteria,1K544@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	-	-	-	-	-	-	-	-	-	-	adh_short_C2
GDHHQS2_k127_5305798_0	35754.JNYJ01000046_gene3102	1.293e-80	278.0	COG1520@1|root,COG1520@2|Bacteria,2I9S4@201174|Actinobacteria,4D97G@85008|Micromonosporales	201174|Actinobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
GDHHQS2_k127_5305798_1	479434.Sthe_2597	5.766e-13	71.0	COG2843@1|root,COG2843@2|Bacteria,2G78I@200795|Chloroflexi	200795|Chloroflexi	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
GDHHQS2_k127_5313746_2	247156.NFA_13320	2.966e-68	250.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4FX0X@85025|Nocardiaceae	201174|Actinobacteria	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
GDHHQS2_k127_5313746_1	2754.EH55_09940	1.1e-80	275.0	COG0740@1|root,COG0740@2|Bacteria,3T9R6@508458|Synergistetes	508458|Synergistetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
GDHHQS2_k127_5313746_0	1280706.AUJE01000007_gene2850	2.392e-155	495.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H2EF@909932|Negativicutes	909932|Negativicutes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
GDHHQS2_k127_5318989_0	1229780.BN381_450009	6.482e-41	161.0	COG0723@1|root,COG0723@2|Bacteria,2H0R5@201174|Actinobacteria	201174|Actinobacteria	C	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
GDHHQS2_k127_5318989_1	1229780.BN381_450008	2.611e-32	142.0	COG2010@1|root,COG2010@2|Bacteria,2H49G@201174|Actinobacteria	201174|Actinobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
GDHHQS2_k127_5325682_2	1385520.N802_16285	2.148e-42	160.0	COG3741@1|root,COG3741@2|Bacteria,2IEZX@201174|Actinobacteria,4FIQZ@85021|Intrasporangiaceae	201174|Actinobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
GDHHQS2_k127_5325682_0	110319.CF8_0171	3.075e-102	350.0	COG3930@1|root,COG3930@2|Bacteria,2IATJ@201174|Actinobacteria,4DT1A@85009|Propionibacteriales	201174|Actinobacteria	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
GDHHQS2_k127_5325682_1	1385518.N798_05110	1.98e-90	313.0	COG0189@1|root,COG0189@2|Bacteria,2IDUN@201174|Actinobacteria,4FFU2@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
GDHHQS2_k127_535024_0	318424.EU78_05320	1.693e-212	672.0	COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,235Z1@1762|Mycobacteriaceae	201174|Actinobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
GDHHQS2_k127_535024_1	523791.Kkor_1669	4.497e-05	54.0	COG1846@1|root,COG1846@2|Bacteria,1NIQA@1224|Proteobacteria,1SSAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
GDHHQS2_k127_5357694_0	1123023.JIAI01000007_gene1945	3.774e-43	164.0	COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5FV@85010|Pseudonocardiales	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5357694_1	1128421.JAGA01000002_gene855	3.729e-42	157.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
GDHHQS2_k127_5393598_1	1146883.BLASA_1901	5.866e-23	102.0	COG2332@1|root,COG2332@2|Bacteria,2GZPB@201174|Actinobacteria	201174|Actinobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
GDHHQS2_k127_5393598_0	1229780.BN381_310054	2.772e-102	344.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
GDHHQS2_k127_5394829_3	1051501.AYTL01000030_gene2941	2.322e-23	108.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,4HCF5@91061|Bacilli,1ZBTY@1386|Bacillus	91061|Bacilli	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
GDHHQS2_k127_5394829_1	324602.Caur_0384	2.37e-39	150.0	COG0292@1|root,COG0292@2|Bacteria,2G6V4@200795|Chloroflexi,375NZ@32061|Chloroflexia	32061|Chloroflexia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
GDHHQS2_k127_5394829_4	1440053.JOEI01000033_gene4839	1.531e-14	74.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
GDHHQS2_k127_5394829_0	679197.HMPREF9336_01151	1.995e-55	204.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
GDHHQS2_k127_5394829_2	1169152.AXVD01000004_gene617	3.252e-24	105.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria,4FVQD@85025|Nocardiaceae	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
GDHHQS2_k127_5398209_3	441769.ABFU01000066_gene1927	0.000158	45.0	COG0824@1|root,COG0824@2|Bacteria,1VD1M@1239|Firmicutes,4HK00@91061|Bacilli,1ZI72@1386|Bacillus	91061|Bacilli	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
GDHHQS2_k127_5398209_2	290340.AAur_1753	3.844e-32	129.0	COG0346@1|root,COG0346@2|Bacteria,2IQJB@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_5398209_0	1333523.L593_04510	3.348e-69	248.0	COG0604@1|root,arCOG01458@2157|Archaea,2XU0Q@28890|Euryarchaeota,23SPC@183963|Halobacteria	183963|Halobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	qor1	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS2_k127_5398209_1	1246995.AFR_16350	1.932e-48	185.0	COG0491@1|root,COG0491@2|Bacteria,2HGYG@201174|Actinobacteria,4DHF6@85008|Micromonosporales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS2_k127_5400129_2	445975.COLSTE_02399	1.078e-64	226.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4CV1K@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
GDHHQS2_k127_5400129_0	665571.STHERM_c18430	7.519e-189	597.0	COG0538@1|root,COG0538@2|Bacteria,2J5RP@203691|Spirochaetes	203691|Spirochaetes	C	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
GDHHQS2_k127_5400129_1	526227.Mesil_1713	1.874e-73	254.0	COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
GDHHQS2_k127_5409514_1	1121353.H924_08230	1.723e-30	129.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria,22KB8@1653|Corynebacteriaceae	201174|Actinobacteria	KT	Phage shock protein A (IM30), suppresses sigma54-dependent transcription	pspA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
GDHHQS2_k127_5409514_0	1313172.YM304_39270	4.935e-152	494.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,4CMWD@84992|Acidimicrobiia	84992|Acidimicrobiia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
GDHHQS2_k127_5416181_1	56110.Oscil6304_1363	4.495e-91	311.0	COG0136@1|root,COG0136@2|Bacteria,1G0E6@1117|Cyanobacteria,1H8EA@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
GDHHQS2_k127_5416181_0	1283283.ATXA01000010_gene4578	1.54e-151	490.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4ERII@85013|Frankiales	201174|Actinobacteria	E	Belongs to the aspartokinase family	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
GDHHQS2_k127_5416181_2	1356854.N007_15430	5.768e-35	143.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H9V0@91061|Bacilli	91061|Bacilli	G	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Pro_isomerase
GDHHQS2_k127_5417686_2	631454.N177_1524	5.127e-05	46.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JMZF@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_08005	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS2_k127_5417686_1	471852.Tcur_3942	3.43e-24	106.0	COG0745@1|root,COG0745@2|Bacteria,2I2Z1@201174|Actinobacteria,4EJHI@85012|Streptosporangiales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
GDHHQS2_k127_5417686_0	1229780.BN381_10220	1.675e-124	409.0	COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,3UX9M@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
GDHHQS2_k127_5431688_1	1121272.KB903251_gene843	1.593e-66	237.0	2CIYT@1|root,2Z7R8@2|Bacteria,2IDER@201174|Actinobacteria,4DHKK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5431688_0	219305.MCAG_02312	4.138e-166	531.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4D901@85008|Micromonosporales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL1	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
GDHHQS2_k127_5432107_2	1313172.YM304_35550	1.382e-130	432.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
GDHHQS2_k127_5432107_0	28444.JODQ01000018_gene7258	2.607e-139	463.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4EI1F@85012|Streptosporangiales	201174|Actinobacteria	C	Proton-conducting membrane transporter	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
GDHHQS2_k127_5432107_1	1118054.CAGW01000043_gene1151	1.73e-138	464.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,4H9YR@91061|Bacilli,26SE0@186822|Paenibacillaceae	91061|Bacilli	CP	Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
GDHHQS2_k127_5432171_0	1128421.JAGA01000003_gene3449	2.75e-111	375.0	COG0505@1|root,COG0505@2|Bacteria,2NNMS@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955,ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383,iYO844.BSU15510	CPSase_sm_chain,GATase
GDHHQS2_k127_5432171_1	1179773.BN6_63180	2.152e-104	356.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4DXZ8@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
GDHHQS2_k127_5432171_2	446470.Snas_3150	3.571e-104	347.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4EYAC@85014|Glycomycetales	201174|Actinobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
GDHHQS2_k127_5432171_3	326427.Cagg_3362	2.229e-59	215.0	COG2065@1|root,COG2065@2|Bacteria,2G6WS@200795|Chloroflexi,375J4@32061|Chloroflexia	32061|Chloroflexia	F	Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
GDHHQS2_k127_5432171_4	35754.JNYJ01000001_gene7155	2.963e-35	140.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4DJDR@85008|Micromonosporales	201174|Actinobacteria	P	Carbonic anhydrase	can	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
GDHHQS2_k127_5433384_2	1229780.BN381_250052	2.792e-37	142.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,3UXBM@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	modA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
GDHHQS2_k127_5433384_1	1313172.YM304_37330	1.274e-112	370.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria	201174|Actinobacteria	P	Molybdate ABC transporter	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
GDHHQS2_k127_5433384_0	1229780.BN381_250050	3.543e-118	394.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,3UX9Q@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	TOBE domain	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
GDHHQS2_k127_5433384_3	1121385.AQXW01000004_gene2824	1.035e-05	48.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,1ZW7U@145357|Dermacoccaceae	201174|Actinobacteria	C	Aldo/keto reductase family	yghZ	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
GDHHQS2_k127_5438418_0	469371.Tbis_2890	0.0	1140.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4DYC3@85010|Pseudonocardiales	201174|Actinobacteria	C	Dehydrogenase E1 component	kgd	-	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
GDHHQS2_k127_5445887_0	1120936.KB907220_gene2028	1.723e-210	680.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4EFGY@85012|Streptosporangiales	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
GDHHQS2_k127_5448021_2	570952.ATVH01000015_gene1310	4e-17	84.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,2JTTA@204441|Rhodospirillales	204441|Rhodospirillales	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
GDHHQS2_k127_5448021_1	397278.JOJN01000002_gene744	4.963e-54	199.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4DN46@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_5448021_0	555088.DealDRAFT_2926	5.116e-104	366.0	COG4188@1|root,COG4188@2|Bacteria,1UGK7@1239|Firmicutes,24CXP@186801|Clostridia	186801|Clostridia	S	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2
GDHHQS2_k127_5448278_1	1306174.JODP01000002_gene5744	6.514e-15	80.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter (Permease)	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GDHHQS2_k127_5448278_0	1121272.KB903257_gene5462	1.76e-101	336.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4D8X9@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS2_k127_5450829_0	1081644.IMCC13023_02600	4.262e-225	714.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4FMXF@85023|Microbacteriaceae	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
GDHHQS2_k127_5450829_1	411469.EUBHAL_03120	1.436e-31	126.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,25UZ0@186806|Eubacteriaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
GDHHQS2_k127_5452456_0	935866.JAER01000009_gene779	5.088e-57	212.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4DTDY@85009|Propionibacteriales	201174|Actinobacteria	GK	ROK family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
GDHHQS2_k127_5494503_1	1313172.YM304_33770	1.052e-57	214.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
GDHHQS2_k127_5494503_0	1173025.GEI7407_0777	8.771e-69	245.0	COG0404@1|root,COG0404@2|Bacteria,1G0GR@1117|Cyanobacteria,1H70I@1150|Oscillatoriales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
GDHHQS2_k127_5499052_2	1146883.BLASA_1890	0.0004828	44.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
GDHHQS2_k127_5499052_1	40571.JOEA01000041_gene4664	4.1e-16	90.0	COG3088@1|root,COG3088@2|Bacteria,2GTYU@201174|Actinobacteria,4EC70@85010|Pseudonocardiales	201174|Actinobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
GDHHQS2_k127_5499052_0	40571.JOEA01000041_gene4666	9.754e-50	185.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4E3DR@85010|Pseudonocardiales	201174|Actinobacteria	CO	Thiol-disulfide isomerase-like thioredoxin	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
GDHHQS2_k127_5500415_0	1385935.N836_31090	1.381e-14	83.0	2E3N5@1|root,32YKB@2|Bacteria,1G9J7@1117|Cyanobacteria,1HGJF@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5500415_1	28444.JODQ01000018_gene7278	2.959e-05	54.0	COG0510@1|root,COG0510@2|Bacteria,2HE1I@201174|Actinobacteria	201174|Actinobacteria	M	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
GDHHQS2_k127_5512620_2	1380390.JIAT01000011_gene2307	2.808e-19	92.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,4CR1A@84995|Rubrobacteria	84995|Rubrobacteria	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_5512620_0	388051.AUFE01000037_gene3153	4.419e-90	312.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2VMB9@28216|Betaproteobacteria,1K1M2@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM intradiol ring-cleavage dioxygenase	-	-	1.13.11.1	ko:K03381	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R00817,R04258,R05299,R08114,R08115,R09134	RC00388,RC00535,RC01366	ko00000,ko00001,ko00002,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
GDHHQS2_k127_5512620_1	426117.M446_1960	2.804e-80	276.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSK0@28211|Alphaproteobacteria,1JTJ8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	macA	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
GDHHQS2_k127_5513707_1	1869.MB27_35725	3.227e-18	89.0	COG1181@1|root,COG1181@2|Bacteria,2HP1M@201174|Actinobacteria,4DHKT@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C
GDHHQS2_k127_5513707_0	1380370.JIBA01000010_gene2596	5.541e-80	273.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4FFF6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
GDHHQS2_k127_5513707_2	765420.OSCT_2305	1.286e-15	81.0	COG0366@1|root,COG0366@2|Bacteria,2G7QC@200795|Chloroflexi,376X0@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
GDHHQS2_k127_5517328_0	1121272.KB903253_gene6887	1.421e-146	476.0	COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria,4D9D4@85008|Micromonosporales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
GDHHQS2_k127_5517328_1	1123504.JQKD01000002_gene3996	2.536e-45	174.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,4ABT0@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
GDHHQS2_k127_5518519_2	1048834.TC41_1002	5.617e-36	141.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,279WU@186823|Alicyclobacillaceae	91061|Bacilli	C	NifU-like N terminal domain	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
GDHHQS2_k127_5518519_0	485913.Krac_8822	7.149e-142	461.0	COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
GDHHQS2_k127_5518519_1	266117.Rxyl_0171	1.748e-84	285.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4CPSF@84995|Rubrobacteria	84995|Rubrobacteria	O	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
GDHHQS2_k127_5523294_0	1304865.JAGF01000001_gene120	8.799e-116	381.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4F0HN@85016|Cellulomonadaceae	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS2_k127_5523294_1	1179773.BN6_56190	2.268e-31	132.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria,4E1XJ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
GDHHQS2_k127_5524219_0	670487.Ocepr_0114	5.136e-06	53.0	COG1524@1|root,COG1524@2|Bacteria,1WMNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
GDHHQS2_k127_5524219_1	118168.MC7420_3049	2.531e-05	53.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7DY@1150|Oscillatoriales	1117|Cyanobacteria	A	Wd40 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
GDHHQS2_k127_5524650_2	748727.CLJU_c14840	4.08e-44	168.0	COG0834@1|root,COG3437@1|root,COG0834@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,PAS,PAS_4,SBP_bac_3
GDHHQS2_k127_5524650_0	1448389.BAVQ01000006_gene3238	1.338e-75	263.0	COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
GDHHQS2_k127_5524650_1	316278.SynRCC307_0301	2.03e-61	221.0	COG0434@1|root,COG0434@2|Bacteria,1G0P7@1117|Cyanobacteria,1GZTC@1129|Synechococcus	1117|Cyanobacteria	S	biogenesis protein btpA	btpA	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
GDHHQS2_k127_5524650_3	1068980.ARVW01000001_gene7824	4.77e-29	123.0	28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria,4DZ4Y@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Wyosine base formation	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N,Wyosine_form
GDHHQS2_k127_5528577_1	1123267.JONN01000002_gene86	1.162e-84	294.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,2K035@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
GDHHQS2_k127_5528577_2	1131462.DCF50_p1860	2.2e-82	286.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,2602H@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
GDHHQS2_k127_5528577_0	1229780.BN381_100149	1.259e-148	485.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,3UW9X@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Probable RNA and SrmB- binding site of polymerase A	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
GDHHQS2_k127_5528577_3	42256.RradSPS_0866	2.815e-33	132.0	COG2805@1|root,COG2805@2|Bacteria,2HPWY@201174|Actinobacteria,4CP76@84995|Rubrobacteria	84995|Rubrobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
GDHHQS2_k127_5544390_1	1230341.MJ3_00045	2.012e-07	62.0	COG2340@1|root,COG2340@2|Bacteria,1TSUX@1239|Firmicutes,4HDMJ@91061|Bacilli	91061|Bacilli	N	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CAP_assoc_N,SLH
GDHHQS2_k127_5544390_0	1122609.AUGT01000030_gene2524	2.094e-73	254.0	COG2872@1|root,COG2872@2|Bacteria,2I8P6@201174|Actinobacteria	201174|Actinobacteria	S	Threonyl alanyl tRNA synthetase SAD	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
GDHHQS2_k127_5547878_0	1121877.JQKF01000009_gene578	5.764e-103	341.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4CMQ2@84992|Acidimicrobiia	84992|Acidimicrobiia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S
GDHHQS2_k127_5547878_1	1123023.JIAI01000002_gene5476	4.759e-51	185.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4DYTH@85010|Pseudonocardiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
GDHHQS2_k127_5549966_2	195105.CN97_05695	1.414e-09	65.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
GDHHQS2_k127_5549966_1	555079.Toce_1352	3.392e-29	121.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,42GU7@68295|Thermoanaerobacterales	186801|Clostridia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
GDHHQS2_k127_5549966_0	767817.Desgi_2673	3.931e-35	145.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,260MF@186807|Peptococcaceae	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
GDHHQS2_k127_5552370_0	1254432.SCE1572_49335	7.178e-166	532.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,42MXU@68525|delta/epsilon subdivisions,2WK28@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Type III restriction protein res subunit	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,Helicase_C,ResIII
GDHHQS2_k127_5552370_1	994479.GL877878_gene2228	1.382e-50	195.0	COG1518@1|root,COG3293@1|root,COG1518@2|Bacteria,COG3293@2|Bacteria	2|Bacteria	L	Transposase	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1,DUF4096
GDHHQS2_k127_5552690_1	760568.Desku_1320	1.755e-47	174.0	COG0772@1|root,COG0772@2|Bacteria,1TQ82@1239|Firmicutes,248QS@186801|Clostridia,26015@186807|Peptococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FHA,FTSW_RODA_SPOVE
GDHHQS2_k127_5552690_0	1110697.NCAST_27_00030	3.95e-67	248.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4FUHY@85025|Nocardiaceae	201174|Actinobacteria	M	Penicillin binding protein transpeptidase domain	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
GDHHQS2_k127_5553085_1	1313172.YM304_09200	4.822e-13	74.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K07552,ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2,2.A.1.2.65	-	-	MFS_1,Sugar_tr,Usp
GDHHQS2_k127_5553085_0	309801.trd_0913	4.178e-72	251.0	COG0151@1|root,COG0151@2|Bacteria,2G7M4@200795|Chloroflexi,27XHM@189775|Thermomicrobia	189775|Thermomicrobia	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
GDHHQS2_k127_5560269_0	1223543.GP2_032_00290	9.747e-229	722.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4GD6P@85026|Gordoniaceae	201174|Actinobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
GDHHQS2_k127_5564310_1	266117.Rxyl_0904	0.0004317	43.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
GDHHQS2_k127_5564310_0	219305.MCAG_03794	1.217e-96	324.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4DAEY@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
GDHHQS2_k127_5564395_1	196162.Noca_1523	1.672e-35	139.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4DQV0@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
GDHHQS2_k127_5564395_0	479432.Sros_0368	4.56e-71	248.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4EI9T@85012|Streptosporangiales	201174|Actinobacteria	L	DbpA RNA binding domain	deaD	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
GDHHQS2_k127_5565752_1	1033806.HTIA_1814	5.371e-18	88.0	COG1670@1|root,arCOG00842@2157|Archaea,2XVC6@28890|Euryarchaeota,23TBU@183963|Halobacteria	183963|Halobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
GDHHQS2_k127_5565752_0	502025.Hoch_3638	5.999e-58	214.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42S6D@68525|delta/epsilon subdivisions,2WNEA@28221|Deltaproteobacteria,2Z344@29|Myxococcales	28221|Deltaproteobacteria	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
GDHHQS2_k127_5571590_1	479434.Sthe_0511	6.667e-71	258.0	COG1306@1|root,COG1306@2|Bacteria,2G81Y@200795|Chloroflexi,27XJ9@189775|Thermomicrobia	189775|Thermomicrobia	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4015
GDHHQS2_k127_5571590_0	525909.Afer_0248	5.439e-82	284.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS2_k127_5574249_0	555088.DealDRAFT_0870	8.354e-160	523.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248QX@186801|Clostridia	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
GDHHQS2_k127_5574249_2	1229780.BN381_10335	6.309e-08	59.0	291CY@1|root,2ZNZT@2|Bacteria,2HDEE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5574249_1	1283299.AUKG01000003_gene270	8.433e-42	157.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4CP6Q@84995|Rubrobacteria	84995|Rubrobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS2_k127_557689_1	28444.JODQ01000002_gene4076	9.766e-49	178.0	COG0123@1|root,COG0123@2|Bacteria,2I8UK@201174|Actinobacteria	201174|Actinobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
GDHHQS2_k127_557689_2	521393.JH806633_gene1767	6.233e-29	126.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4D4KC@85005|Actinomycetales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
GDHHQS2_k127_557689_0	1122612.AUBA01000008_gene2176	1.639e-58	205.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,2K4RU@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
GDHHQS2_k127_557689_3	1440774.Y900_002830	2.004e-20	93.0	COG0748@1|root,COG0748@2|Bacteria,2IIRE@201174|Actinobacteria,239MD@1762|Mycobacteriaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
GDHHQS2_k127_5579902_0	1279009.ADICEAN_00059	2.73e-221	700.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,47KS7@768503|Cytophagia	976|Bacteroidetes	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
GDHHQS2_k127_5579902_1	1121272.KB903252_gene968	8.495e-22	96.0	COG1158@1|root,COG1158@2|Bacteria,2IKUK@201174|Actinobacteria,4DF83@85008|Micromonosporales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5583529_2	880073.Calab_3584	3.11e-71	252.0	COG0297@1|root,COG0297@2|Bacteria,2NQKG@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
GDHHQS2_k127_5583529_0	1380393.JHVP01000005_gene3588	2.353e-142	462.0	COG1181@1|root,COG1181@2|Bacteria,2I7XS@201174|Actinobacteria,4EWIZ@85013|Frankiales	2|Bacteria	M	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	ATP-grasp_4,Dala_Dala_lig_C,Dala_Dala_lig_N
GDHHQS2_k127_5583529_1	1032480.MLP_27670	1.309e-117	385.0	COG1181@1|root,COG1181@2|Bacteria,2IAF3@201174|Actinobacteria,4DVZ5@85009|Propionibacteriales	201174|Actinobacteria	M	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp,ATP-grasp_4,CPSase_L_D2
GDHHQS2_k127_5585289_2	1122214.AQWH01000008_gene1566	4.699e-06	58.0	COG1879@1|root,COG1879@2|Bacteria,1N1FF@1224|Proteobacteria,2UDI7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
GDHHQS2_k127_5585289_0	1122214.AQWH01000008_gene1568	1.587e-60	228.0	COG1172@1|root,COG1172@2|Bacteria,1MX1K@1224|Proteobacteria,2TUYJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
GDHHQS2_k127_5585289_1	266117.Rxyl_0206	1.156e-41	161.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,4CR1A@84995|Rubrobacteria	84995|Rubrobacteria	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_5587716_0	28444.JODQ01000002_gene4220	4.388e-81	279.0	COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4EICG@85012|Streptosporangiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_5587716_1	1122609.AUGT01000025_gene216	2.114e-06	51.0	COG5002@1|root,COG5002@2|Bacteria,2I3U8@201174|Actinobacteria,4DTR8@85009|Propionibacteriales	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_5590918_3	861454.HMPREF9099_01744	4.475e-23	100.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,27J8R@186928|unclassified Lachnospiraceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
GDHHQS2_k127_5590918_0	1229780.BN381_330109	2.396e-190	603.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,3UW9K@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
GDHHQS2_k127_5590918_1	1385520.N802_12480	5.29e-59	213.0	2F7D1@1|root,33ZU2@2|Bacteria,2ITDT@201174|Actinobacteria,4FISI@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5590918_2	1122138.AQUZ01000036_gene5466	4.165e-58	208.0	COG1595@1|root,COG1595@2|Bacteria,2GKFQ@201174|Actinobacteria	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_5599801_2	1229780.BN381_160029	1.585e-58	210.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
GDHHQS2_k127_5599801_0	1313172.YM304_35610	1.808e-95	323.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
GDHHQS2_k127_5599801_1	1313172.YM304_35620	3.82e-92	309.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
GDHHQS2_k127_5607743_1	159450.NH14_13655	0.0009993	52.0	COG4961@1|root,COG4961@2|Bacteria,1RKE7@1224|Proteobacteria,2VZN3@28216|Betaproteobacteria,1K3TC@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Putative Tad-like Flp pilus-assembly	-	-	-	-	-	-	-	-	-	-	-	-	Tad,Tad_C
GDHHQS2_k127_5607743_0	309801.trd_A0617	5.483e-05	53.0	COG4961@1|root,COG4961@2|Bacteria,2GBBK@200795|Chloroflexi,27YP1@189775|Thermomicrobia	189775|Thermomicrobia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
GDHHQS2_k127_5634262_3	240016.ABIZ01000001_gene3379	0.0002622	49.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
GDHHQS2_k127_5634262_1	1121877.JQKF01000037_gene1816	7.854e-47	175.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4CN7S@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
GDHHQS2_k127_5634262_0	525909.Afer_0598	1.136e-121	409.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4CN8B@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Mur ligase family, glutamate ligase domain	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
GDHHQS2_k127_5634262_2	408672.NBCG_02084	2.12e-45	171.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Biotin_lipoyl,E3_binding
GDHHQS2_k127_5635556_1	264198.Reut_A2080	1.347e-76	267.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,1K14J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
GDHHQS2_k127_5635556_0	945713.IALB_1797	1.777e-199	639.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria	2|Bacteria	C	malic enzyme	maeB	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.38,1.1.1.40,2.3.1.8	ko:K00027,ko:K00029,ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020	M00169,M00172,M00357,M00579	R00214,R00216,R00230,R00921	RC00004,RC00105,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
GDHHQS2_k127_5646161_1	317655.Sala_2603	0.0004929	49.0	2ENRK@1|root,33GCR@2|Bacteria,1NDBH@1224|Proteobacteria,2UICT@28211|Alphaproteobacteria,2KDQW@204457|Sphingomonadales	204457|Sphingomonadales	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core3
GDHHQS2_k127_5646161_0	269796.Rru_A1483	1.422e-19	102.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JW6B@204441|Rhodospirillales	204441|Rhodospirillales	F	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
GDHHQS2_k127_5656293_1	446462.Amir_3077	2.592e-67	234.0	COG1012@1|root,COG1012@2|Bacteria,2HF1C@201174|Actinobacteria,4EA29@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
GDHHQS2_k127_5656293_2	1123320.KB889563_gene6427	1.837e-51	191.0	COG0702@1|root,COG0702@2|Bacteria,2GM39@201174|Actinobacteria	201174|Actinobacteria	GM	NmrA family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,RmlD_sub_bind
GDHHQS2_k127_5656293_3	1120965.AUBV01000016_gene94	8.614e-22	99.0	2BWYK@1|root,32R5D@2|Bacteria,4NS4D@976|Bacteroidetes	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4,PAS_8
GDHHQS2_k127_5656293_0	1305737.JAFX01000001_gene1972	2.097e-81	280.0	COG1235@1|root,COG1235@2|Bacteria,4NM16@976|Bacteroidetes,47U32@768503|Cytophagia	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
GDHHQS2_k127_5656293_4	1307761.L21SP2_1298	8.58e-11	68.0	2DSTU@1|root,33HDW@2|Bacteria	2|Bacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_5684465_0	1123023.JIAI01000003_gene2647	4.811e-122	400.0	COG4670@1|root,COG4670@2|Bacteria	2|Bacteria	I	ketone body catabolic process	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
GDHHQS2_k127_5684465_1	1123023.JIAI01000003_gene2646	1.368e-39	149.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
GDHHQS2_k127_5685362_0	391009.Tmel_0560	8.529e-124	406.0	COG4608@1|root,COG4608@2|Bacteria,2GCGD@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS2_k127_5685362_1	484019.THA_1394	6.974e-122	399.0	COG0444@1|root,COG0444@2|Bacteria,2GCDR@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS2_k127_5685362_2	1150474.JQJI01000002_gene1198	3.893e-66	230.0	COG1173@1|root,COG1173@2|Bacteria,2GCK9@200918|Thermotogae	200918|Thermotogae	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
GDHHQS2_k127_5690470_2	546414.Deide_19970	1.747e-25	112.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1WI0V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EU	Peptidase S9 prolyl oligopeptidase active site	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
GDHHQS2_k127_5690470_3	1333998.M2A_0986	1.538e-10	72.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2UGK6@28211|Alphaproteobacteria,4BQX9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Phosphatidylglycerophosphatase A	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
GDHHQS2_k127_5690470_1	768671.ThimaDRAFT_0126	1.133e-58	219.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales	135613|Chromatiales	G	pfam mofrl	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
GDHHQS2_k127_5690470_0	1229780.BN381_80129	9.417e-82	283.0	COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,3UWCG@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	GO:0003674,GO:0003824,GO:0004617,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
GDHHQS2_k127_5701135_1	1380350.JIAP01000003_gene4976	2.024e-35	143.0	COG1129@1|root,COG1129@2|Bacteria,1P3ZB@1224|Proteobacteria,2VET1@28211|Alphaproteobacteria,43I52@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	ABC transporter	xylG	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
GDHHQS2_k127_5701135_0	536019.Mesop_1445	7.87e-158	506.0	COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,2TR9B@28211|Alphaproteobacteria,43GUA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	xylH	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
GDHHQS2_k127_5708509_0	1121946.AUAX01000003_gene1632	1.926e-156	498.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4D9FR@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
GDHHQS2_k127_5712000_2	1307761.L21SP2_1483	1.356e-09	59.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
GDHHQS2_k127_5712000_0	1201290.M902_2886	4.347e-41	166.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2MSSI@213481|Bdellovibrionales,2WRDI@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
GDHHQS2_k127_5712000_1	1313172.YM304_34870	1.071e-16	81.0	COG5663@1|root,COG5663@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
GDHHQS2_k127_5714248_1	235985.BBPN01000026_gene1441	2.97e-22	104.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,2NGGN@228398|Streptacidiphilus	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
GDHHQS2_k127_5714248_0	266940.Krad_0878	2.367e-47	181.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
GDHHQS2_k127_5714248_2	1380391.JIAS01000011_gene5419	3.313e-05	52.0	COG0510@1|root,COG0510@2|Bacteria,1N77Z@1224|Proteobacteria,2TRW6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Choline kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH,Choline_kinase
GDHHQS2_k127_5717481_0	404380.Gbem_3102	2.441e-52	189.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,43U6J@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
GDHHQS2_k127_5717481_1	188626.HMPREF0321_2750	1.586e-31	130.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,1ZVSW@145357|Dermacoccaceae	201174|Actinobacteria	J	Telomere recombination	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
GDHHQS2_k127_5717481_2	1385521.N803_02155	5.018e-18	89.0	COG0664@1|root,COG0664@2|Bacteria,2I8MP@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,cNMP_binding
GDHHQS2_k127_5717481_3	1121019.AUMN01000008_gene3265	0.0001291	46.0	COG2890@1|root,COG2890@2|Bacteria,2GNC1@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the protein N5-glutamine methyltransferase family	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
GDHHQS2_k127_5721904_0	1304883.KI912532_gene1857	9.69e-61	224.0	COG0642@1|root,COG2203@1|root,COG2703@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2703@2|Bacteria,1RGKE@1224|Proteobacteria,2WHKS@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,Response_reg
GDHHQS2_k127_5725491_0	118173.KB235914_gene2483	1.647e-26	116.0	COG0515@1|root,COG0515@2|Bacteria,1GA6I@1117|Cyanobacteria,1HH09@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
GDHHQS2_k127_5725491_1	1123024.AUII01000016_gene1298	7.831e-11	69.0	2EHMB@1|root,33BD3@2|Bacteria,2I3SC@201174|Actinobacteria,4EF8N@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5725705_0	926554.KI912617_gene4814	9.281e-71	247.0	COG2041@1|root,COG2041@2|Bacteria,1WJB2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
GDHHQS2_k127_5725705_1	1313172.YM304_09590	8.234e-32	133.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4CNXW@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
GDHHQS2_k127_573340_0	471852.Tcur_1023	8.296e-294	936.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4EH06@85012|Streptosporangiales	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
GDHHQS2_k127_573340_1	1120949.KB903326_gene3089	8.178e-85	290.0	COG1230@1|root,COG1230@2|Bacteria,2GMRZ@201174|Actinobacteria,4DBPK@85008|Micromonosporales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
GDHHQS2_k127_573340_2	1380390.JIAT01000010_gene4657	4.905e-06	57.0	COG4454@1|root,COG4454@2|Bacteria,2I7WC@201174|Actinobacteria,4CTCK@84995|Rubrobacteria	84995|Rubrobacteria	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
GDHHQS2_k127_5733629_0	313606.M23134_07531	2.656e-117	386.0	COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes,47KCH@768503|Cytophagia	976|Bacteroidetes	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
GDHHQS2_k127_5733629_1	867903.ThesuDRAFT_00783	0.000227	53.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1V3V0@1239|Firmicutes,24QVX@186801|Clostridia	186801|Clostridia	H	Molybdopterin converting factor subunit	-	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
GDHHQS2_k127_5740522_1	1440774.Y900_023755	9.367e-22	96.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,232XI@1762|Mycobacteriaceae	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase	gnd2	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1122	6PGD,NAD_binding_2
GDHHQS2_k127_5740522_0	1380390.JIAT01000015_gene5806	1.073e-151	492.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria	201174|Actinobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
GDHHQS2_k127_5740522_2	159087.Daro_2742	8.108e-11	62.0	COG4912@1|root,COG4912@2|Bacteria,1QR4Q@1224|Proteobacteria,2VTTV@28216|Betaproteobacteria,2KZ1W@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
GDHHQS2_k127_5751042_0	1229780.BN381_70002	2.584e-82	278.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,3UW8N@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
GDHHQS2_k127_5751042_1	1121272.KB903289_gene4139	3.933e-37	146.0	COG0789@1|root,COG0789@2|Bacteria,2IC98@201174|Actinobacteria,4DGJB@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
GDHHQS2_k127_5751042_2	693986.MOC_4521	3.144e-10	63.0	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria,1JUXK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM thioesterase superfamily	MA20_36950	-	-	-	-	-	-	-	-	-	-	-	4HBT
GDHHQS2_k127_5756723_1	365528.KB891215_gene2615	1.385e-46	181.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4ES13@85013|Frankiales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_5756723_0	1313172.YM304_01390	1.691e-70	247.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_5756723_2	1246995.AFR_01125	1.771e-06	49.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4D8P2@85008|Micromonosporales	201174|Actinobacteria	V	COG0577 ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GDHHQS2_k127_5758123_0	1172188.KB911820_gene2749	1.166e-176	558.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4FEE3@85021|Intrasporangiaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
GDHHQS2_k127_5758123_1	1380393.JHVP01000004_gene590	2.114e-07	52.0	COG4635@1|root,COG4635@2|Bacteria,2IMZZ@201174|Actinobacteria,4EX95@85013|Frankiales	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
GDHHQS2_k127_5759585_0	710696.Intca_3312	1.173e-160	518.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4FFMD@85021|Intrasporangiaceae	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
GDHHQS2_k127_5759585_1	391625.PPSIR1_06983	1.342e-157	507.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2YUK3@29|Myxococcales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
GDHHQS2_k127_5759585_2	298655.KI912266_gene6160	7.812e-48	175.0	COG0454@1|root,COG0456@2|Bacteria,2IRBV@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_5760734_0	1380346.JNIH01000034_gene227	3.966e-98	322.0	COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria	201174|Actinobacteria	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
GDHHQS2_k127_5760734_2	1089545.KB913037_gene6397	3.592e-34	136.0	COG2964@1|root,COG2964@2|Bacteria,2IHSD@201174|Actinobacteria,4E604@85010|Pseudonocardiales	201174|Actinobacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_22
GDHHQS2_k127_5760734_1	42256.RradSPS_2920	6.094e-48	178.0	COG0590@1|root,COG0590@2|Bacteria,2I9KR@201174|Actinobacteria	201174|Actinobacteria	FJ	CMP dCMP deaminase, zinc-binding	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
GDHHQS2_k127_5766607_4	105422.BBPM01000008_gene6251	1.296e-12	74.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,2NHI5@228398|Streptacidiphilus	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.67	ko:K21802	ko00627,ko01120,map00627,map01120	-	R05699	RC00075	ko00000,ko00001,ko01000	-	-	-	Aldedh
GDHHQS2_k127_5766607_0	1123277.KB893172_gene512	4.204e-181	580.0	COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,47NTH@768503|Cytophagia	976|Bacteroidetes	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897,ko:K18660	ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R03383	RC00004,RC00014,RC00137	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,PP-binding
GDHHQS2_k127_5766607_2	525904.Tter_2442	5.231e-102	340.0	COG0667@1|root,COG0667@2|Bacteria,2NP23@2323|unclassified Bacteria	2|Bacteria	C	Aldo/keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
GDHHQS2_k127_5766607_1	1187851.A33M_4369	1.607e-159	515.0	COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,2TT29@28211|Alphaproteobacteria,3FDFT@34008|Rhodovulum	28211|Alphaproteobacteria	E	Creatinase/Prolidase N-terminal domain	eutD	-	3.4.13.9,3.5.4.44	ko:K01271,ko:K15783	ko00260,ko01100,map00260,map01100	-	R09800	RC02661	ko00000,ko00001,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_5766607_3	1121377.KB906398_gene2789	3.387e-66	239.0	COG1304@1|root,COG1304@2|Bacteria,1WJ7T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	FMN-dependent dehydrogenase	-	-	1.1.3.46	ko:K16422	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06633	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
GDHHQS2_k127_5775396_2	298655.KI912267_gene7046	5.667e-09	58.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4ERJA@85013|Frankiales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
GDHHQS2_k127_5775396_1	351607.Acel_1887	4.412e-27	116.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4ESVY@85013|Frankiales	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
GDHHQS2_k127_5775396_0	883.DvMF_0523	4.3e-75	270.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2M94B@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
GDHHQS2_k127_5790413_0	498848.TaqDRAFT_4704	1.109e-113	383.0	COG0606@1|root,COG0606@2|Bacteria,1WI18@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	ATPase with chaperone activity	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
GDHHQS2_k127_5790413_3	1232453.BAIF02000089_gene2877	2.436e-50	189.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,268X6@186813|unclassified Clostridiales	186801|Clostridia	LU	DNA recombination-mediator protein A	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
GDHHQS2_k127_5790413_2	502558.EGYY_09490	4.376e-58	213.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CUWF@84998|Coriobacteriia	84998|Coriobacteriia	D	Belongs to the 'phage' integrase family. XerC subfamily	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS2_k127_5790413_1	351607.Acel_1546	6.126e-90	303.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4ERYG@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	whiG	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS2_k127_5794606_1	1123319.AUBE01000001_gene1965	6.317e-16	83.0	COG1266@1|root,COG1266@2|Bacteria,2GKRA@201174|Actinobacteria	201174|Actinobacteria	S	Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
GDHHQS2_k127_5794606_0	1123247.AUIJ01000024_gene723	5.602e-78	277.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	MA20_19425	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS2_k127_580333_1	1123229.AUBC01000007_gene128	7.448e-58	212.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VF27@28211|Alphaproteobacteria,3K6DU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
GDHHQS2_k127_580333_2	1243664.CAVL020000016_gene1928	1.478e-19	94.0	COG0662@1|root,COG0662@2|Bacteria,1UB82@1239|Firmicutes,4IMKS@91061|Bacilli,1ZKDA@1386|Bacillus	91061|Bacilli	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_580333_0	1120949.KB903299_gene6018	5.443e-62	227.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4D96Y@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
GDHHQS2_k127_580333_3	1283299.AUKG01000002_gene5072	6.85e-17	86.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4CRGJ@84995|Rubrobacteria	84995|Rubrobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_5819111_1	546271.Selsp_0752	3.004e-22	105.0	COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,4H227@909932|Negativicutes	909932|Negativicutes	D	SpoIID LytB domain protein	spoIID	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
GDHHQS2_k127_5819111_0	1120950.KB892745_gene2885	3.158e-131	430.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4DND6@85009|Propionibacteriales	201174|Actinobacteria	M	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	murA	GO:0008150,GO:0040007	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
GDHHQS2_k127_5819111_2	754252.PFREUD_21660	7.997e-17	82.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria	201174|Actinobacteria	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
GDHHQS2_k127_5826899_6	215803.DB30_1749	2.803e-39	154.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2YU4F@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
GDHHQS2_k127_5826899_4	391625.PPSIR1_28283	5.102e-68	246.0	COG0204@1|root,COG0204@2|Bacteria,1RF5A@1224|Proteobacteria,4300N@68525|delta/epsilon subdivisions,2WVIK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
GDHHQS2_k127_5826899_3	1229780.BN381_100200	3.601e-87	308.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria,3UXBY@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
GDHHQS2_k127_5826899_2	1120950.KB892823_gene471	1.984e-100	337.0	COG0598@1|root,COG0598@2|Bacteria,2GKNZ@201174|Actinobacteria,4DPEQ@85009|Propionibacteriales	201174|Actinobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
GDHHQS2_k127_5826899_0	880072.Desac_1040	1.623e-171	548.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
GDHHQS2_k127_5826899_5	1313172.YM304_38350	2.488e-41	168.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CN27@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
GDHHQS2_k127_5826899_1	330214.NIDE4062	7.342e-103	339.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	pcd	GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_5841851_0	479435.Kfla_2876	5.674e-50	182.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4DNSG@85009|Propionibacteriales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
GDHHQS2_k127_5841851_1	861299.J421_2311	1.717e-11	67.0	2FKCY@1|root,34C0C@2|Bacteria,1ZU3I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5841851_2	1050202.KB913024_gene2431	1.368e-08	58.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,408TA@622450|Actinopolysporales	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
GDHHQS2_k127_5847172_3	867903.ThesuDRAFT_01661	6.347e-60	219.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3WCI1@538999|Clostridiales incertae sedis	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
GDHHQS2_k127_5847172_2	298655.KI912266_gene5159	3.151e-76	276.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4ERI0@85013|Frankiales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
GDHHQS2_k127_5847172_0	1229780.BN381_140011	1.348e-101	341.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,3UWA7@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
GDHHQS2_k127_5847172_1	882083.SacmaDRAFT_3703	4.611e-98	332.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4DYWZ@85010|Pseudonocardiales	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
GDHHQS2_k127_5849788_3	1123239.KB898626_gene664	1.536e-16	87.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli	91061|Bacilli	O	Belongs to the peptidase S8 family	-	-	-	ko:K13277	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	A2M_N,CW_binding_2,Peptidase_S8,SLH
GDHHQS2_k127_5849788_1	1120948.KB903245_gene3450	5.837e-40	162.0	COG1228@1|root,COG1228@2|Bacteria,2GKRZ@201174|Actinobacteria,4DZ8J@85010|Pseudonocardiales	201174|Actinobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_5849788_2	195250.CM001776_gene3871	3.48e-38	161.0	COG0793@1|root,COG0793@2|Bacteria,1G1YJ@1117|Cyanobacteria,1GYEZ@1129|Synechococcus	1117|Cyanobacteria	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41,Tricorn_C1
GDHHQS2_k127_5849788_0	1158165.KB898875_gene53	5.988e-48	190.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVW7@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
GDHHQS2_k127_5856086_3	670487.Ocepr_0770	1.696e-15	78.0	COG0137@1|root,COG0137@2|Bacteria,1WIER@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
GDHHQS2_k127_5856086_2	1713.JOFV01000004_gene3297	1.055e-21	102.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4F27G@85016|Cellulomonadaceae	201174|Actinobacteria	K	Regulates arginine biosynthesis genes	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
GDHHQS2_k127_5856086_0	264732.Moth_2287	2.574e-110	372.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,42F28@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.13,2.6.1.17	ko:K00819,ko:K00821	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00667,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_5856086_1	1313172.YM304_20800	1.215e-61	217.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CMYC@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
GDHHQS2_k127_5864990_0	1095767.CAHD01000209_gene119	6.276e-71	247.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria,4F2ZV@85016|Cellulomonadaceae	201174|Actinobacteria	S	Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
GDHHQS2_k127_5864990_3	1121877.JQKF01000002_gene1631	0.0009765	48.0	2DDS5@1|root,2ZJ1Y@2|Bacteria,2HDMP@201174|Actinobacteria,4CP3T@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5864990_2	1033743.CAES01000078_gene3629	3.648e-25	117.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,4H9WD@91061|Bacilli,26R0X@186822|Paenibacillaceae	91061|Bacilli	I	to YegS from E. coli	dagK	GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
GDHHQS2_k127_5864990_1	1394178.AWOO02000044_gene4470	9.33e-35	141.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4EH6A@85012|Streptosporangiales	201174|Actinobacteria	L	DSHCT	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
GDHHQS2_k127_5869569_4	40571.JOEA01000025_gene6031	4.202e-57	204.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,2I98A@201174|Actinobacteria,4E0T5@85010|Pseudonocardiales	201174|Actinobacteria	KP	PFAM Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
GDHHQS2_k127_5869569_3	101510.RHA1_ro11219	2.154e-133	439.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4FXJT@85025|Nocardiaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
GDHHQS2_k127_5869569_1	1123024.AUII01000010_gene684	1.976e-171	547.0	COG0477@1|root,COG2814@2|Bacteria,2GNBV@201174|Actinobacteria,4E2F7@85010|Pseudonocardiales	201174|Actinobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_5869569_0	882083.SacmaDRAFT_2957	7.022e-272	852.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4DXK7@85010|Pseudonocardiales	201174|Actinobacteria	P	E1-E2 ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
GDHHQS2_k127_5869569_2	649638.Trad_1258	5.44e-151	482.0	COG0074@1|root,COG0074@2|Bacteria,1WJBR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
GDHHQS2_k127_5869733_1	219305.MCAG_04449	2.025e-05	51.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DBGJ@85008|Micromonosporales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigA	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS2_k127_5869733_0	926550.CLDAP_17420	2.064e-181	590.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
GDHHQS2_k127_5910751_0	765910.MARPU_07220	6.113e-134	441.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
GDHHQS2_k127_5910751_1	1380387.JADM01000006_gene1104	3.389e-33	131.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1XJPI@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
GDHHQS2_k127_5940263_2	1283287.KB822585_gene2723	8.882e-30	124.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4DR1A@85009|Propionibacteriales	201174|Actinobacteria	T	zinc-ribbon domain	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
GDHHQS2_k127_5940263_1	1380347.JNII01000005_gene2879	1.577e-44	170.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4ESMT@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MerR	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
GDHHQS2_k127_5940263_0	264732.Moth_1357	1.677e-45	175.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
GDHHQS2_k127_5941699_1	316274.Haur_3653	2.058e-26	121.0	COG2856@1|root,COG2856@2|Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5941699_0	867903.ThesuDRAFT_01964	1.345e-43	168.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,3WDDN@538999|Clostridiales incertae sedis	186801|Clostridia	E	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
GDHHQS2_k127_5941699_2	742743.HMPREF9453_00842	3.482e-09	59.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,4H53N@909932|Negativicutes	909932|Negativicutes	S	TrpR family protein YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
GDHHQS2_k127_5946347_0	1229780.BN381_140046	2.567e-120	406.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,3UWMB@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	GIY-YIG type nucleases (URI domain)	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
GDHHQS2_k127_5946674_2	1121272.KB903290_gene4687	5.427e-51	186.0	COG0842@1|root,COG0842@2|Bacteria,2IART@201174|Actinobacteria	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
GDHHQS2_k127_5946674_0	68170.KL590533_gene5261	3.561e-79	280.0	COG0842@1|root,COG0842@2|Bacteria,2I0HP@201174|Actinobacteria,4E1P2@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
GDHHQS2_k127_5946674_1	101510.RHA1_ro05648	8.392e-68	246.0	COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,4FWRE@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
GDHHQS2_k127_5950887_0	1120936.KB907208_gene905	5.905e-41	166.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4EFTZ@85012|Streptosporangiales	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
GDHHQS2_k127_5950887_2	383372.Rcas_3310	8.738e-06	57.0	2ET4Z@1|root,33KP2@2|Bacteria,2G97T@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5950887_1	1121015.N789_05920	4.698e-07	52.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XCE9@135614|Xanthomonadales	135614|Xanthomonadales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
GDHHQS2_k127_5958467_1	1336235.JAEG01000001_gene2494	4.298e-134	450.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria,4B8YD@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
GDHHQS2_k127_5958467_0	1499967.BAYZ01000025_gene285	2.51e-192	629.0	COG0018@1|root,COG0018@2|Bacteria,2NP0H@2323|unclassified Bacteria	2|Bacteria	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iECABU_c1320.ECABU_c21380,iECNA114_1301.ECNA114_1940,iECSE_1348.ECSE_2111,iECSF_1327.ECSF_1736,iEcolC_1368.EcolC_1756,iJN746.PP_5089,iLF82_1304.LF82_0128,iNRG857_1313.NRG857_09405,iUMNK88_1353.UMNK88_2348,ic_1306.c2291	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
GDHHQS2_k127_5958467_2	485914.Hmuk_1651	1.415e-16	89.0	COG0454@1|root,arCOG00845@2157|Archaea,2XTIN@28890|Euryarchaeota,23TT3@183963|Halobacteria	183963|Halobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_5963861_0	1121377.KB906401_gene3384	6.571e-130	443.0	COG3903@1|root,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_22,BTAD,DUF4062,GerE,NB-ARC,TPR_12
GDHHQS2_k127_5964614_0	1123023.JIAI01000001_gene5930	2.535e-84	290.0	COG2218@1|root,COG2218@2|Bacteria,2I686@201174|Actinobacteria	201174|Actinobacteria	C	Glutamate synthase	-	-	2.1.1.21	ko:K22082	ko00680,ko01120,map00680,map01120	-	R01586	RC00554	ko00000,ko00001,ko01000	-	-	-	GXGXG
GDHHQS2_k127_597366_2	1380391.JIAS01000015_gene221	1.085e-08	64.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0367 Asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
GDHHQS2_k127_597366_0	591158.SSMG_03442	2.077e-45	178.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS2_k127_597366_1	1089544.KB912942_gene1994	9.729e-09	66.0	COG0842@1|root,COG0842@2|Bacteria,2GX2M@201174|Actinobacteria,4E11H@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
GDHHQS2_k127_597366_4	195253.Syn6312_1970	1.459e-05	53.0	2E7MG@1|root,3323C@2|Bacteria,1GCRI@1117|Cyanobacteria	1117|Cyanobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
GDHHQS2_k127_597366_3	1550073.JROH01000011_gene2043	1.785e-06	57.0	COG5265@1|root,COG5265@2|Bacteria,1MWU5@1224|Proteobacteria,2U5U0@28211|Alphaproteobacteria,2KEAT@204457|Sphingomonadales	204457|Sphingomonadales	O	HPr kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_5984910_0	502025.Hoch_5724	2.055e-30	125.0	COG1610@1|root,COG1610@2|Bacteria,1PS1I@1224|Proteobacteria,43A7B@68525|delta/epsilon subdivisions,2X2EM@28221|Deltaproteobacteria,2Z2BW@29|Myxococcales	28221|Deltaproteobacteria	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
GDHHQS2_k127_5984910_2	446466.Cfla_3495	1.041e-20	102.0	COG0584@1|root,COG0584@2|Bacteria,2GNM5@201174|Actinobacteria,4F1A2@85016|Cellulomonadaceae	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
GDHHQS2_k127_5984910_1	1229780.BN381_310068	3.23e-28	117.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,3UWR8@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
GDHHQS2_k127_5984910_4	590998.Celf_2464	0.0002084	52.0	COG1652@1|root,COG1652@2|Bacteria,2GQMU@201174|Actinobacteria,4F2PE@85016|Cellulomonadaceae	201174|Actinobacteria	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
GDHHQS2_k127_6017475_1	160799.PBOR_09550	1.685e-11	70.0	COG1846@1|root,COG1846@2|Bacteria,1V7G6@1239|Firmicutes,4HM9I@91061|Bacilli,26XQ9@186822|Paenibacillaceae	91061|Bacilli	K	MarR family transcriptional regulator	-	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
GDHHQS2_k127_6017475_0	1385519.N801_03980	2.505e-169	548.0	COG0477@1|root,COG0477@2|Bacteria,2GJ09@201174|Actinobacteria,4FEK2@85021|Intrasporangiaceae	201174|Actinobacteria	EGP	Fungal trichothecene efflux pump (TRI12)	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_602117_1	243230.DR_0547	2.791e-54	207.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
GDHHQS2_k127_602117_2	195253.Syn6312_1279	3.621e-17	93.0	2CC95@1|root,2Z8VE@2|Bacteria,1G2FQ@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_602117_0	1313172.YM304_21620	8.896e-130	424.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4CMVA@84992|Acidimicrobiia	84992|Acidimicrobiia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
GDHHQS2_k127_6029180_1	1227495.C487_03928	1.431e-46	179.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23STH@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
GDHHQS2_k127_6029180_0	1155718.KB891899_gene1824	2.932e-77	273.0	COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria	201174|Actinobacteria	C	Tryptophan halogenase	-	-	-	ko:K16033	ko01051,ko01052,ko01130,map01051,map01052,map01130	-	R09851	RC01363	ko00000,ko00001	-	-	-	Trp_halogenase
GDHHQS2_k127_6042189_1	502025.Hoch_1681	8.248e-21	105.0	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,42NGH@68525|delta/epsilon subdivisions,2WKS6@28221|Deltaproteobacteria,2YV7C@29|Myxococcales	28221|Deltaproteobacteria	M	RmlD substrate binding domain	-	-	1.1.1.394,1.1.1.412	ko:K21271,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD
GDHHQS2_k127_6042189_2	1254432.SCE1572_49595	1.14e-19	102.0	28PVU@1|root,2ZCGC@2|Bacteria,1QT5D@1224|Proteobacteria,43570@68525|delta/epsilon subdivisions,2X96D@28221|Deltaproteobacteria,2Z272@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6045458_2	1313172.YM304_27690	9.082e-49	186.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4CNBV@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
GDHHQS2_k127_6045458_0	1121035.AUCH01000003_gene1313	2.17e-77	268.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,2KUAD@206389|Rhodocyclales	206389|Rhodocyclales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
GDHHQS2_k127_6045458_3	1907.SGLAU_08480	6.949e-48	180.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria	201174|Actinobacteria	S	Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
GDHHQS2_k127_6045458_1	1128421.JAGA01000002_gene1529	1.571e-64	227.0	COG0259@1|root,COG0259@2|Bacteria,2NQT9@2323|unclassified Bacteria	2|Bacteria	H	Pfam:PNPOx_C	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pdxH	PNP_phzG_C,Putative_PNPOx
GDHHQS2_k127_6058673_1	397278.JOJN01000005_gene774	2.965e-104	351.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_6058673_2	298655.KI912266_gene4577	1.182e-66	240.0	COG2423@1|root,COG2423@2|Bacteria,2GJ0U@201174|Actinobacteria	201174|Actinobacteria	E	ornithine cyclodeaminase	ocd	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
GDHHQS2_k127_6058673_0	1283283.ATXA01000006_gene1843	7.582e-124	409.0	COG0329@1|root,COG0329@2|Bacteria,2IEBJ@201174|Actinobacteria	201174|Actinobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
GDHHQS2_k127_6058673_3	285535.JOEY01000073_gene9814	4.714e-66	240.0	COG0329@1|root,COG0329@2|Bacteria,2I92Q@201174|Actinobacteria	201174|Actinobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
GDHHQS2_k127_6058673_4	439496.RBY4I_51	5.102e-05	52.0	COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,2TT29@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0006 Xaa-Pro aminopeptidase	eutD	-	3.4.13.9,3.5.4.44	ko:K01271,ko:K15783	ko00260,ko01100,map00260,map01100	-	R09800	RC02661	ko00000,ko00001,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_6068464_0	502025.Hoch_2002	2.633e-85	291.0	COG1319@1|root,COG1319@2|Bacteria,1PG5C@1224|Proteobacteria,43EJH@68525|delta/epsilon subdivisions,2X9UI@28221|Deltaproteobacteria,2Z2GS@29|Myxococcales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
GDHHQS2_k127_6068464_1	1476583.DEIPH_ctg032orf0049	1.756e-05	47.0	COG2080@1|root,COG2080@2|Bacteria,1WK3N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
GDHHQS2_k127_6071917_2	953739.SVEN_6336	1.133e-12	69.0	COG1247@1|root,COG1247@2|Bacteria,2GR9D@201174|Actinobacteria	201174|Actinobacteria	M	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_6071917_0	1122622.ATWJ01000014_gene448	3.915e-192	607.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4FG41@85021|Intrasporangiaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
GDHHQS2_k127_6071917_1	479433.Caci_0054	8.11e-83	283.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
GDHHQS2_k127_6074633_1	1101190.ARWB01000001_gene3799	1.429e-17	83.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2TT5T@28211|Alphaproteobacteria,36X30@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis protein	rfbB	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
GDHHQS2_k127_6074633_0	331869.BAL199_12116	3.249e-112	372.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2TQPI@28211|Alphaproteobacteria,4BR5J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Glucose-1-phosphate thymidylyltransferase	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
GDHHQS2_k127_6074633_2	1305737.JAFX01000001_gene2000	7.399e-08	59.0	COG1215@1|root,COG1215@2|Bacteria,4PKF3@976|Bacteroidetes,47XY0@768503|Cytophagia	976|Bacteroidetes	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GDHHQS2_k127_6076411_1	1356854.N007_12390	7.459e-48	186.0	COG0483@1|root,COG0483@2|Bacteria,1UKWB@1239|Firmicutes,4ITKN@91061|Bacilli	91061|Bacilli	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
GDHHQS2_k127_6076411_0	1123251.ATWM01000016_gene1403	2.167e-53	193.0	COG0471@1|root,COG0471@2|Bacteria,2HXIC@201174|Actinobacteria,4FH0P@85021|Intrasporangiaceae	201174|Actinobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
GDHHQS2_k127_6076531_0	1335757.SPICUR_08590	1.335e-28	126.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales	135613|Chromatiales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
GDHHQS2_k127_6089934_1	1304275.C41B8_18397	5.581e-26	110.0	COG4927@1|root,COG4927@2|Bacteria,1NKHP@1224|Proteobacteria,1SFS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
GDHHQS2_k127_6089934_2	1313172.YM304_16810	2.035e-16	79.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
GDHHQS2_k127_6089934_0	926550.CLDAP_13130	3.281e-56	205.0	COG3153@1|root,COG3153@2|Bacteria,2G8MF@200795|Chloroflexi	200795|Chloroflexi	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_6113806_1	1283299.AUKG01000001_gene2722	3.852e-34	139.0	COG1051@1|root,COG1051@2|Bacteria,2HQ01@201174|Actinobacteria,4CRFN@84995|Rubrobacteria	84995|Rubrobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
GDHHQS2_k127_6113806_0	1161401.ASJA01000027_gene41	3.357e-58	211.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,43W7Q@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	MA20_07390	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
GDHHQS2_k127_6118926_5	882083.SacmaDRAFT_1928	3.851e-12	67.0	COG1856@1|root,COG1856@2|Bacteria,2H3RG@201174|Actinobacteria	201174|Actinobacteria	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
GDHHQS2_k127_6118926_3	882083.SacmaDRAFT_1927	1.079e-33	137.0	COG0509@1|root,COG0509@2|Bacteria,2H7M7@201174|Actinobacteria	201174|Actinobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
GDHHQS2_k127_6118926_0	882083.SacmaDRAFT_1926	5.782e-83	284.0	COG0095@1|root,COG0095@2|Bacteria,2H716@201174|Actinobacteria	201174|Actinobacteria	H	PFAM Biotin lipoate A B protein ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6118926_2	309801.trd_0143	1.153e-48	179.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
GDHHQS2_k127_6118926_1	309801.trd_0144	1.501e-52	192.0	COG0509@1|root,COG0509@2|Bacteria	2|Bacteria	E	glycine decarboxylation via glycine cleavage system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
GDHHQS2_k127_6118926_4	309801.trd_0145	5.245e-13	71.0	28XG9@1|root,2ZJDS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6125754_3	1476876.JOJO01000031_gene3979	0.0006055	49.0	COG0793@1|root,COG0793@2|Bacteria,2I1TN@201174|Actinobacteria	201174|Actinobacteria	M	Peptidase family S41	nsr	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
GDHHQS2_k127_6125754_0	429009.Adeg_0063	5.245e-109	364.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
GDHHQS2_k127_6125754_1	1410665.JNKR01000004_gene1468	2.819e-75	264.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,4H271@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
GDHHQS2_k127_6125754_2	1313172.YM304_10420	1.826e-27	113.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
GDHHQS2_k127_6159210_1	469383.Cwoe_0818	1.51e-87	299.0	COG0015@1|root,COG0015@2|Bacteria,2GKBR@201174|Actinobacteria,4CPI0@84995|Rubrobacteria	84995|Rubrobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
GDHHQS2_k127_6159210_0	710686.Mycsm_02512	9.892e-128	421.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,233HP@1762|Mycobacteriaceae	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
GDHHQS2_k127_6159362_1	1238186.AOCN01000007_gene621	5.049e-47	181.0	COG0182@1|root,COG0182@2|Bacteria,2GJJA@201174|Actinobacteria,4FPZ3@85023|Microbacteriaceae	201174|Actinobacteria	J	Initiation factor 2 subunit family	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
GDHHQS2_k127_6159362_3	561175.KB894097_gene219	2.407e-26	115.0	COG3467@1|root,COG3467@2|Bacteria,2I5VH@201174|Actinobacteria	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
GDHHQS2_k127_6159362_0	287986.DV20_34085	1.61e-99	341.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4E0CV@85010|Pseudonocardiales	201174|Actinobacteria	F	Amidohydrolase family	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
GDHHQS2_k127_6159362_2	211114.JOEF01000006_gene2392	2.482e-45	168.0	COG3542@1|root,COG3542@2|Bacteria,2IFG5@201174|Actinobacteria,4E4Z5@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
GDHHQS2_k127_6159362_4	1122622.ATWJ01000011_gene2165	1.426e-10	70.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4FJH5@85021|Intrasporangiaceae	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
GDHHQS2_k127_6159865_0	643648.Slip_1669	1.707e-287	900.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,42JIP@68298|Syntrophomonadaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
GDHHQS2_k127_6159865_1	1385521.N803_12850	3.842e-126	413.0	COG1226@1|root,COG1226@2|Bacteria,2HXZ8@201174|Actinobacteria,4FISA@85021|Intrasporangiaceae	201174|Actinobacteria	U	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
GDHHQS2_k127_6171133_0	383372.Rcas_0561	3.441e-140	461.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi,37597@32061|Chloroflexia	32061|Chloroflexia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
GDHHQS2_k127_6171133_1	1385519.N801_15410	2.536e-08	60.0	2C2EP@1|root,33H2C@2|Bacteria,2HZGM@201174|Actinobacteria,4FJHN@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6176183_0	1385518.N798_14800	5.358e-83	286.0	COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4FEY1@85021|Intrasporangiaceae	201174|Actinobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
GDHHQS2_k127_6176183_2	428125.CLOLEP_02648	2.838e-22	108.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,3WH7A@541000|Ruminococcaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
GDHHQS2_k127_6176183_1	1123267.JONN01000001_gene1618	2.637e-32	131.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria	1224|Proteobacteria	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54,5.4.99.5	ko:K01626,ko:K03856,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
GDHHQS2_k127_6181167_0	1122622.ATWJ01000008_gene2607	1.198e-71	251.0	COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,4FJXN@85021|Intrasporangiaceae	201174|Actinobacteria	IT	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
GDHHQS2_k127_6181167_1	350688.Clos_2753	8.02e-61	217.0	COG3797@1|root,COG3797@2|Bacteria,1V426@1239|Firmicutes,24HUG@186801|Clostridia,36WZF@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
GDHHQS2_k127_6181167_2	68170.KL590492_gene6165	5.49e-10	65.0	2BNCR@1|root,32H0E@2|Bacteria,2HRIE@201174|Actinobacteria,4EASX@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
GDHHQS2_k127_6183509_2	65393.PCC7424_3730	2.207e-37	142.0	COG0102@1|root,COG0102@2|Bacteria,1G512@1117|Cyanobacteria,3KHR7@43988|Cyanothece	1117|Cyanobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
GDHHQS2_k127_6183509_1	468556.AQYG01000051_gene2487	4.077e-40	152.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4GAV1@85026|Gordoniaceae	201174|Actinobacteria	J	Ribosomal protein S9/S16	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
GDHHQS2_k127_6183509_0	562970.Btus_0198	2.572e-118	396.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,4HB16@91061|Bacilli,277WG@186823|Alicyclobacillaceae	91061|Bacilli	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS11275	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
GDHHQS2_k127_6183509_3	243230.DR_0302	1.164e-06	53.0	COG0449@1|root,COG0449@2|Bacteria,1WIM6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
GDHHQS2_k127_6184923_3	1179773.BN6_17560	1.265e-41	156.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DXJD@85010|Pseudonocardiales	201174|Actinobacteria	V	Daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990,ko:K18232	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC_tran,DUF4162
GDHHQS2_k127_6184923_1	1229203.KI301992_gene853	1.015e-115	380.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,3UWGP@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	U	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
GDHHQS2_k127_6184923_2	1089549.AZUQ01000001_gene1363	3.494e-98	338.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4EZ99@85014|Glycomycetales	201174|Actinobacteria	P	Na+/H+ antiporter 1	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
GDHHQS2_k127_6184923_0	1123024.AUII01000014_gene4336	5.143e-133	434.0	COG0191@1|root,COG0191@2|Bacteria,2GM5P@201174|Actinobacteria,4DZK9@85010|Pseudonocardiales	201174|Actinobacteria	G	fructose-bisphosphate aldolase, class II, yeast E. coli subtype	fba	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
GDHHQS2_k127_6184923_4	985054.JQEZ01000004_gene723	1.455e-11	72.0	COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2UFAC@28211|Alphaproteobacteria,4NCDQ@97050|Ruegeria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF454)	ybaN	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
GDHHQS2_k127_6188471_0	1220583.GOACH_27_00090	7.723e-105	356.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4GA2Z@85026|Gordoniaceae	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
GDHHQS2_k127_6188471_1	1229780.BN381_50178	1.01e-19	92.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,3UWK3@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
GDHHQS2_k127_6191222_0	1041147.AUFB01000005_gene2452	3.609e-177	561.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,4B8E4@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_6191222_1	305900.GV64_21905	1.3e-44	180.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1XIGQ@135619|Oceanospirillales	135619|Oceanospirillales	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
GDHHQS2_k127_6192828_0	1229780.BN381_10199	5.293e-69	256.0	COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria	201174|Actinobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6192828_1	56110.Oscil6304_0426	2.268e-11	68.0	2EV68@1|root,33NM1@2|Bacteria,1GFZ0@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6193239_0	1487953.JMKF01000028_gene1369	2.035e-152	495.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1FZX5@1117|Cyanobacteria,1HH7U@1150|Oscillatoriales	1117|Cyanobacteria	KOT	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Response_reg
GDHHQS2_k127_6193239_1	306281.AJLK01000002_gene811	2.537e-61	218.0	COG1051@1|root,COG1051@2|Bacteria,1G4H7@1117|Cyanobacteria,1JH32@1189|Stigonemataceae	1117|Cyanobacteria	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
GDHHQS2_k127_6198627_0	479434.Sthe_1458	4.645e-46	179.0	COG0083@1|root,COG0083@2|Bacteria,2G6MP@200795|Chloroflexi,27Y5U@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
GDHHQS2_k127_6198627_1	1411123.JQNH01000001_gene955	8.164e-31	131.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phenazine biosynthesis protein PhzF	phzF	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
GDHHQS2_k127_6202652_3	710687.KI912270_gene6508	1.139e-09	66.0	2DZGK@1|root,32VA1@2|Bacteria,2IJIB@201174|Actinobacteria,239KB@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_5
GDHHQS2_k127_6202652_1	1313172.YM304_37650	2.806e-67	235.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4CMZF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sigma-70, region 4	sigR	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_6202652_4	83332.Rv3221A	1.268e-06	55.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,23A1R@1762|Mycobacteriaceae	201174|Actinobacteria	K	anti-sigma factor	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
GDHHQS2_k127_6202652_0	1229780.BN381_110020	1.905e-74	264.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,3UXC9@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Pfam:Zinicin_2	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
GDHHQS2_k127_6202652_2	1123368.AUIS01000001_gene2055	1.746e-29	133.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,2NCJ8@225057|Acidithiobacillales	225057|Acidithiobacillales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
GDHHQS2_k127_621569_0	675635.Psed_2259	2.308e-114	388.0	COG1129@1|root,COG1172@1|root,COG1129@2|Bacteria,COG1172@2|Bacteria,2GJ3F@201174|Actinobacteria,4EA78@85010|Pseudonocardiales	201174|Actinobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	3.6.3.17	ko:K10440,ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran,BPD_transp_2
GDHHQS2_k127_621569_1	1122214.AQWH01000008_gene1566	6.77e-68	243.0	COG1879@1|root,COG1879@2|Bacteria,1N1FF@1224|Proteobacteria,2UDI7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
GDHHQS2_k127_6217063_1	1116232.AHBF01000083_gene7660	6.318e-23	114.0	COG3903@1|root,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
GDHHQS2_k127_6217063_0	443598.AUFA01000051_gene26	3.13e-34	150.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
GDHHQS2_k127_6217960_3	134676.ACPL_3154	0.0004214	50.0	COG1309@1|root,COG1309@2|Bacteria,2GP59@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
GDHHQS2_k127_6217960_0	1282876.BAOK01000002_gene550	2.1e-70	252.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
GDHHQS2_k127_6217960_1	216594.MMAR_1557	8.745e-67	238.0	COG2141@1|root,COG2141@2|Bacteria,2I9BN@201174|Actinobacteria,237VG@1762|Mycobacteriaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_6217960_2	1382304.JNIL01000001_gene972	1.382e-50	184.0	COG3173@1|root,COG3173@2|Bacteria,1TSCJ@1239|Firmicutes,4HB2X@91061|Bacilli	91061|Bacilli	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
GDHHQS2_k127_6218851_0	305700.B447_12022	9.521e-11	74.0	2ETVI@1|root,33MCS@2|Bacteria,1PUAN@1224|Proteobacteria,2W09P@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6220713_0	42256.RradSPS_0884	3.031e-142	463.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4CPHP@84995|Rubrobacteria	84995|Rubrobacteria	H	Elongator protein 3 MiaB NifB	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
GDHHQS2_k127_6220713_2	1504981.KO116_4341	1.613e-68	243.0	COG1028@1|root,COG1028@2|Bacteria,1R3ZC@1224|Proteobacteria,1RZQ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
GDHHQS2_k127_6220713_1	502025.Hoch_5157	4.227e-141	458.0	COG0515@1|root,COG0515@2|Bacteria,1R0MY@1224|Proteobacteria,43CYD@68525|delta/epsilon subdivisions,2X86J@28221|Deltaproteobacteria,2Z3M5@29|Myxococcales	502025.Hoch_5157|-	KLT	Domain of unknown function (DUF4032)	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6220713_3	749414.SBI_03347	2.579e-29	120.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria	201174|Actinobacteria	L	Glycosylase	nei	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
GDHHQS2_k127_6227963_3	1242864.D187_007915	1.654e-09	69.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
GDHHQS2_k127_6227963_2	479432.Sros_3148	4.355e-10	67.0	COG2172@1|root,COG2172@2|Bacteria,2I12C@201174|Actinobacteria,4EK73@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
GDHHQS2_k127_6227963_0	1869.MB27_12205	3.426e-46	182.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4DBSK@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS2_k127_6227963_1	1121272.KB903289_gene4301	4.275e-12	70.0	COG1366@1|root,COG1366@2|Bacteria,2GQBG@201174|Actinobacteria,4DFF7@85008|Micromonosporales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
GDHHQS2_k127_6228364_1	28444.JODQ01000001_gene2816	5.304e-81	274.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4EFFB@85012|Streptosporangiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_6228364_0	926569.ANT_09040	1.382e-100	339.0	COG0265@1|root,COG0265@2|Bacteria,2G821@200795|Chloroflexi	200795|Chloroflexi	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
GDHHQS2_k127_6253643_2	1173263.Syn7502_01894	4.052e-13	74.0	COG0589@1|root,COG0589@2|Bacteria,1G6JK@1117|Cyanobacteria,1H1B8@1129|Synechococcus	1117|Cyanobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
GDHHQS2_k127_6253643_1	1463841.JOIR01000005_gene5082	1.201e-54	203.0	COG1946@1|root,COG1946@2|Bacteria,2GMZB@201174|Actinobacteria	201174|Actinobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
GDHHQS2_k127_6253643_0	1306174.JODP01000001_gene4672	3.337e-67	234.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_6255535_1	765912.Thimo_2167	3.683e-56	198.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,1RY5I@1236|Gammaproteobacteria,1WYZK@135613|Chromatiales	135613|Chromatiales	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
GDHHQS2_k127_6255535_0	518766.Rmar_1990	5.867e-126	413.0	COG4257@1|root,COG4257@2|Bacteria	2|Bacteria	V	antibiotic catabolic process	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF5011
GDHHQS2_k127_6256381_0	1068978.AMETH_4361	5.106e-68	239.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria,4DXCN@85010|Pseudonocardiales	201174|Actinobacteria	S	ATP binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
GDHHQS2_k127_6256381_3	1463864.JOGO01000140_gene247	4.889e-12	73.0	COG1846@1|root,COG1846@2|Bacteria,2II46@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
GDHHQS2_k127_6256381_2	28444.JODQ01000011_gene3555	1.729e-29	123.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria,4EIQT@85012|Streptosporangiales	201174|Actinobacteria	S	Roadblock/LC7 domain	cvnB6	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
GDHHQS2_k127_6256381_1	644283.Micau_4170	2.11e-67	252.0	COG2972@1|root,COG2972@2|Bacteria,2I6C6@201174|Actinobacteria	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
GDHHQS2_k127_6260969_1	443218.AS9A_3072	9.535e-87	296.0	COG2267@1|root,COG2267@2|Bacteria,2GJUE@201174|Actinobacteria,23BIX@1762|Mycobacteriaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
GDHHQS2_k127_6260969_0	224911.27352666	1.2e-149	477.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2TVXS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the peptidase S33 family	pipch2	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
GDHHQS2_k127_6280338_0	1179773.BN6_30480	2.764e-167	532.0	COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4DYSV@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_6280338_2	318424.EU78_07630	2.103e-24	114.0	COG2852@1|root,COG2852@2|Bacteria,2GKCY@201174|Actinobacteria,236GB@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4,DUF559
GDHHQS2_k127_6280338_1	1089545.KB913037_gene7704	1.803e-114	374.0	COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4DYVJ@85010|Pseudonocardiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_6288055_1	1120949.KB903299_gene6018	2.705e-36	141.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4D96Y@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
GDHHQS2_k127_6288055_0	1128421.JAGA01000002_gene1463	2.35e-121	397.0	COG0329@1|root,COG0329@2|Bacteria,2NQRS@2323|unclassified Bacteria	2|Bacteria	EM	Protein of unknown function (DUF993)	MA20_16880	-	-	-	-	-	-	-	-	-	-	-	DUF993
GDHHQS2_k127_6288709_1	35754.JNYJ01000030_gene7698	2.108e-19	103.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4DBEY@85008|Micromonosporales	201174|Actinobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
GDHHQS2_k127_6288709_0	1265310.CCBD010000050_gene1895	4.396e-35	140.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,233DM@1762|Mycobacteriaceae	201174|Actinobacteria	K	involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,Guanylate_cyc,NB-ARC
GDHHQS2_k127_6297760_0	1229780.BN381_10313	2.544e-163	520.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,3UWE5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
GDHHQS2_k127_6297874_0	512565.AMIS_66060	2.345e-08	64.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4D8SX@85008|Micromonosporales	201174|Actinobacteria	V	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
GDHHQS2_k127_631549_0	1120948.KB903226_gene5421	1.703e-86	306.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4DY5R@85010|Pseudonocardiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
GDHHQS2_k127_6336850_1	479433.Caci_6164	1.061e-93	316.0	COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GDHHQS2_k127_6336850_3	469383.Cwoe_0731	1.509e-59	225.0	COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria	201174|Actinobacteria	CP	ABC-type Na efflux pump, permease	yhaP	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
GDHHQS2_k127_6336850_2	1206730.BAGA01000010_gene5070	1.115e-79	277.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4FU9K@85025|Nocardiaceae	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA21	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
GDHHQS2_k127_6336850_0	645465.ACUR01000652_gene3813	2.554e-148	484.0	COG1012@1|root,COG1012@2|Bacteria,2GYXB@201174|Actinobacteria	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.5	ko:K00129	ko00010,ko00340,ko00350,ko00360,ko00410,ko00980,ko00982,ko01100,ko01110,ko01120,ko05204,map00010,map00340,map00350,map00360,map00410,map00980,map00982,map01100,map01110,map01120,map05204	-	R00711,R00904,R02536,R02537,R02695,R02697,R03300,R03302,R04882,R04883,R04888,R04889,R04891,R04892,R04996,R07104,R08282,R08283,R08307	RC00047,RC00080,RC00242,RC01735	ko00000,ko00001,ko01000	-	-	-	Aldedh
GDHHQS2_k127_6339064_0	1521187.JPIM01000075_gene2837	1.026e-117	396.0	COG0366@1|root,COG0366@2|Bacteria,2G7QC@200795|Chloroflexi,376X0@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
GDHHQS2_k127_633911_1	926690.KE386573_gene3034	1.842e-45	180.0	COG0477@1|root,arCOG00130@2157|Archaea,2XV7S@28890|Euryarchaeota,23UQQ@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_633911_0	13689.BV96_02976	5.789e-46	175.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,2K1BU@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM amidohydrolase 2	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
GDHHQS2_k127_6379443_1	1448139.AI20_11860	6.756e-81	275.0	COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,1RSCY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the IUNH family	rihA	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047405,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.2.2.1	ko:K01239,ko:K01250	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_0645,iECSE_1348.ECSE_0721,iEcE24377_1341.EcE24377A_0679,iSbBS512_1146.SbBS512_E0598	IU_nuc_hydro
GDHHQS2_k127_6379443_0	1035191.HMPREF0185_00785	3.293e-83	284.0	COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2UA3V@28211|Alphaproteobacteria,2KK1U@204458|Caulobacterales	204458|Caulobacterales	F	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
GDHHQS2_k127_6379443_2	1313172.YM304_20690	4.667e-50	183.0	COG2606@1|root,COG2606@2|Bacteria,2GKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
GDHHQS2_k127_6379443_3	1128421.JAGA01000003_gene3454	2.927e-13	74.0	COG3346@1|root,COG3346@2|Bacteria	2|Bacteria	S	mitochondrial respiratory chain complex IV assembly	surf1	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
GDHHQS2_k127_6385542_3	367299.JOEE01000006_gene876	0.0007427	42.0	COG2186@1|root,COG2186@2|Bacteria,2GZJA@201174|Actinobacteria,4FG6D@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
GDHHQS2_k127_6385542_0	1445613.JALM01000123_gene1430	5.803e-101	337.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4E1VI@85010|Pseudonocardiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
GDHHQS2_k127_6385542_2	1123072.AUDH01000014_gene1274	4.035e-10	64.0	COG0662@1|root,COG0662@2|Bacteria,1RH1E@1224|Proteobacteria,2UKFM@28211|Alphaproteobacteria,2JYG3@204441|Rhodospirillales	204441|Rhodospirillales	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GDHHQS2_k127_6385542_1	397278.JOJN01000009_gene3612	7.066e-58	204.0	COG1878@1|root,COG1878@2|Bacteria,2GUSA@201174|Actinobacteria,4DTVK@85009|Propionibacteriales	201174|Actinobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
GDHHQS2_k127_638865_4	351607.Acel_0544	5.76e-08	60.0	2C0MY@1|root,2ZC2Z@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_638865_2	1380384.JADN01000004_gene2378	1.176e-22	101.0	COG1970@1|root,COG1970@2|Bacteria,4NQ49@976|Bacteroidetes,1I33I@117743|Flavobacteriia	976|Bacteroidetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
GDHHQS2_k127_638865_1	644966.Tmar_1713	5.962e-33	134.0	COG1695@1|root,COG1695@2|Bacteria,1VAGB@1239|Firmicutes,24MZ2@186801|Clostridia,3WDQ1@538999|Clostridiales incertae sedis	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
GDHHQS2_k127_638865_3	1380390.JIAT01000010_gene4253	2.117e-11	75.0	COG1585@1|root,COG1585@2|Bacteria,2HPFR@201174|Actinobacteria,4CQU5@84995|Rubrobacteria	84995|Rubrobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
GDHHQS2_k127_638865_0	1229780.BN381_410018	5.947e-47	172.0	COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,3UWHD@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
GDHHQS2_k127_6392311_0	1123023.JIAI01000011_gene9019	7.495e-114	377.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4DYVV@85010|Pseudonocardiales	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
GDHHQS2_k127_6394166_1	1193181.BN10_760038	1.069e-63	233.0	COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4FES9@85021|Intrasporangiaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9
GDHHQS2_k127_6394166_0	383372.Rcas_2799	4.34e-158	518.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2G64C@200795|Chloroflexi,376K3@32061|Chloroflexia	32061|Chloroflexia	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
GDHHQS2_k127_639669_0	485913.Krac_0284	5.458e-91	306.0	2DBV7@1|root,2ZB9P@2|Bacteria,2G97K@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
GDHHQS2_k127_639669_1	381666.H16_A3401	4.14e-52	199.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,1K0VU@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	degQ	-	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
GDHHQS2_k127_6405161_0	1121468.AUBR01000001_gene525	1.345e-136	445.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,42FGQ@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_6405161_1	2002.JOEQ01000009_gene6462	7.901e-104	349.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4EHUA@85012|Streptosporangiales	201174|Actinobacteria	S	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
GDHHQS2_k127_6405161_2	397278.JOJN01000003_gene1917	1.141e-09	64.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4DNQH@85009|Propionibacteriales	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
GDHHQS2_k127_6407919_2	1313172.YM304_09200	2.127e-30	127.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K07552,ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2,2.A.1.2.65	-	-	MFS_1,Sugar_tr,Usp
GDHHQS2_k127_6407919_1	768670.Calni_1216	2.304e-31	132.0	COG0205@1|root,COG0205@2|Bacteria,2GF3P@200930|Deferribacteres	200930|Deferribacteres	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
GDHHQS2_k127_6407919_3	1408423.JHYA01000004_gene2223	1.141e-28	127.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,4H1UV@909932|Negativicutes	909932|Negativicutes	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA_2	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
GDHHQS2_k127_6407919_4	1521187.JPIM01000033_gene2020	1.396e-19	102.0	COG0823@1|root,COG0823@2|Bacteria,2G8T8@200795|Chloroflexi,377EP@32061|Chloroflexia	32061|Chloroflexia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
GDHHQS2_k127_6407919_0	506534.Rhein_3092	6.303e-33	139.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RYFT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
GDHHQS2_k127_6412023_1	1144305.PMI02_04256	7.515e-10	68.0	COG5412@1|root,COG5412@2|Bacteria,1N710@1224|Proteobacteria,2TVCN@28211|Alphaproteobacteria,2KBUK@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
GDHHQS2_k127_6412023_0	338969.Rfer_1665	7.201e-140	469.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9PT@80864|Comamonadaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
GDHHQS2_k127_641500_1	1128421.JAGA01000002_gene1691	2.726e-51	193.0	COG3694@1|root,COG3694@2|Bacteria,2NQKI@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
GDHHQS2_k127_641500_0	324602.Caur_3313	1.331e-82	283.0	COG4587@1|root,COG4587@2|Bacteria,2G9N0@200795|Chloroflexi,37604@32061|Chloroflexia	32061|Chloroflexia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
GDHHQS2_k127_641500_2	1128421.JAGA01000002_gene1693	3.034e-39	151.0	COG4586@1|root,COG4586@2|Bacteria,2NP49@2323|unclassified Bacteria	2|Bacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GDHHQS2_k127_6422788_1	1133849.O3I_010390	7.902e-19	87.0	COG5646@1|root,COG5646@2|Bacteria,2IT4Y@201174|Actinobacteria,4G31R@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
GDHHQS2_k127_6422788_0	1229780.BN381_80302	4.303e-51	200.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,3UW6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
GDHHQS2_k127_6436344_1	522306.CAP2UW1_0032	1.413e-51	202.0	2D125@1|root,32T9R@2|Bacteria,1N30F@1224|Proteobacteria,2VX2H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6436344_0	1454004.AW11_01835	3.665e-70	252.0	COG2333@1|root,COG2333@2|Bacteria,1RE10@1224|Proteobacteria,2VX35@28216|Betaproteobacteria	28216|Betaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6436344_2	477641.MODMU_2470	0.0001254	46.0	COG1113@1|root,COG1113@2|Bacteria,2GRKY@201174|Actinobacteria,4EWX2@85013|Frankiales	201174|Actinobacteria	E	amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_643698_0	1125863.JAFN01000001_gene1971	8.376e-37	147.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria	1224|Proteobacteria	EM	Belongs to the DapA family	yagE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575	4.1.2.28,4.3.3.7	ko:K01714,ko:K22397	ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01782,R10147	RC00307,RC00572,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
GDHHQS2_k127_6447095_1	2045.KR76_25735	1.315e-12	69.0	COG0745@1|root,COG0745@2|Bacteria,2GMP1@201174|Actinobacteria,4DU85@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_6447095_0	42256.RradSPS_0796	9.832e-42	158.0	COG2050@1|root,COG2050@2|Bacteria,2IR9T@201174|Actinobacteria,4CTI0@84995|Rubrobacteria	84995|Rubrobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
GDHHQS2_k127_6457573_0	861299.J421_0838	2.063e-163	529.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
GDHHQS2_k127_645938_2	266117.Rxyl_0206	1.764e-134	443.0	COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,4CR1A@84995|Rubrobacteria	84995|Rubrobacteria	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
GDHHQS2_k127_645938_0	543632.JOJL01000020_gene629	1.022e-164	526.0	COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_645938_1	1120949.KB903324_gene3336	3.616e-136	440.0	COG1071@1|root,COG1071@2|Bacteria,2I3T8@201174|Actinobacteria,4DBX0@85008|Micromonosporales	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
GDHHQS2_k127_6467530_1	1517416.IDAT_10995	6.029e-14	77.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,2QF6D@267893|Idiomarinaceae	1236|Gammaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
GDHHQS2_k127_6467530_0	471852.Tcur_0001	1.278e-116	383.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4EHA6@85012|Streptosporangiales	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
GDHHQS2_k127_6480936_0	1048339.KB913029_gene4074	4.204e-173	552.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4ERGE@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
GDHHQS2_k127_6491990_0	1123024.AUII01000012_gene4198	1.303e-05	55.0	COG1652@1|root,COG1652@2|Bacteria,2GK68@201174|Actinobacteria,4EF8H@85010|Pseudonocardiales	201174|Actinobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Transglycosylas
GDHHQS2_k127_6515842_1	1380370.JIBA01000010_gene2573	7.934e-13	72.0	COG2334@1|root,COG2334@2|Bacteria,2GQU8@201174|Actinobacteria,4FG7U@85021|Intrasporangiaceae	201174|Actinobacteria	S	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
GDHHQS2_k127_6515842_0	1048339.KB913029_gene3678	6.189e-47	183.0	COG0598@1|root,COG0598@2|Bacteria	2|Bacteria	P	Magnesium transport protein CorA	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
GDHHQS2_k127_6515842_2	1123368.AUIS01000005_gene456	4.772e-09	64.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	mcsS	-	-	-	-	-	-	-	-	-	-	-	BON,MS_channel,Polyketide_cyc
GDHHQS2_k127_6522605_0	562970.Btus_1312	9.669e-88	309.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,4H9SW@91061|Bacilli,2785A@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
GDHHQS2_k127_6522605_1	1313172.YM304_29650	2.234e-07	52.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4CMW0@84992|Acidimicrobiia	84992|Acidimicrobiia	C	e3 binding domain	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
GDHHQS2_k127_6536609_1	1229780.BN381_310104	7.779e-55	192.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
GDHHQS2_k127_6536609_2	1380347.JNII01000006_gene1620	5.087e-36	140.0	COG0346@1|root,COG0346@2|Bacteria,2IS2C@201174|Actinobacteria,4EWD7@85013|Frankiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_6536609_3	408672.NBCG_03854	2.938e-35	143.0	2DP8C@1|root,330ZY@2|Bacteria,2I38N@201174|Actinobacteria,4DS3W@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
GDHHQS2_k127_6536609_0	1122138.AQUZ01000023_gene7874	1.712e-92	310.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_6541072_0	471852.Tcur_4273	3.937e-182	584.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4EGKR@85012|Streptosporangiales	201174|Actinobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iNJ661.Rv3436c	GATase_6,SIS
GDHHQS2_k127_6566796_0	298655.KI912266_gene4067	4.177e-88	299.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4EUVK@85013|Frankiales	201174|Actinobacteria	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
GDHHQS2_k127_6566796_1	1089553.Tph_c15590	4.801e-21	102.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,42GMG@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
GDHHQS2_k127_6566796_2	710111.FraQA3DRAFT_4577	1.65e-06	59.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
GDHHQS2_k127_6568856_0	1054860.KB913030_gene5738	1.637e-128	426.0	COG3673@1|root,COG3673@2|Bacteria,2ID7N@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
GDHHQS2_k127_6568856_1	469383.Cwoe_3000	3.104e-27	114.0	COG3324@1|root,COG3324@2|Bacteria,2GPAS@201174|Actinobacteria	201174|Actinobacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
GDHHQS2_k127_6584628_1	1121019.AUMN01000001_gene518	1.118e-48	180.0	COG0477@1|root,COG2814@2|Bacteria,2H0CW@201174|Actinobacteria,1W8M8@1268|Micrococcaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_6584628_0	306281.AJLK01000102_gene3405	5.957e-55	198.0	COG2258@1|root,COG2258@2|Bacteria,1GE7I@1117|Cyanobacteria	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6585666_1	502025.Hoch_6605	7.094e-166	534.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2YX9H@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase beta thumb	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
GDHHQS2_k127_6585666_2	1386089.N865_08825	2.52e-46	182.0	COG1316@1|root,COG1316@2|Bacteria,2IAW9@201174|Actinobacteria,4FG3U@85021|Intrasporangiaceae	201174|Actinobacteria	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
GDHHQS2_k127_6585666_0	1313172.YM304_07450	7.916e-218	697.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
GDHHQS2_k127_6585666_3	357808.RoseRS_1599	4.557e-21	107.0	COG0406@1|root,COG0406@2|Bacteria,2G731@200795|Chloroflexi,37792@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
GDHHQS2_k127_6585666_4	1223544.GSI01S_06_00780	8.281e-19	100.0	COG0406@1|root,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4GBHP@85026|Gordoniaceae	201174|Actinobacteria	G	Phosphoglycerate mutase family	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
GDHHQS2_k127_6587461_0	867845.KI911784_gene3346	1.541e-94	319.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
GDHHQS2_k127_6589938_1	215803.DB30_8255	4.219e-63	238.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,433VI@68525|delta/epsilon subdivisions,2X3NT@28221|Deltaproteobacteria,2YWPP@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	CheW,HATPase_c,Hpt,Response_reg
GDHHQS2_k127_6589938_3	1183438.GKIL_4449	3.447e-37	151.0	COG0642@1|root,COG2205@2|Bacteria,1G113@1117|Cyanobacteria	1117|Cyanobacteria	T	Signal Transduction Histidine Kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_6589938_0	1229780.BN381_130048	3.557e-241	767.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,3UWC5@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	L	UvrD-like helicase C-terminal domain	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
GDHHQS2_k127_6589938_2	1123023.JIAI01000002_gene5504	4.28e-50	183.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4DXR6@85010|Pseudonocardiales	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
GDHHQS2_k127_6598111_2	1068980.ARVW01000001_gene7837	1.655e-44	169.0	COG1309@1|root,COG1309@2|Bacteria,2IM2B@201174|Actinobacteria	201174|Actinobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
GDHHQS2_k127_6598111_1	1283299.AUKG01000006_gene794	6.396e-57	203.0	COG2329@1|root,COG2329@2|Bacteria,2GTB1@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF3291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3291
GDHHQS2_k127_6598111_0	485913.Krac_8294	1.753e-155	500.0	COG0183@1|root,COG0183@2|Bacteria,2G80D@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
GDHHQS2_k127_6598111_3	1313172.YM304_02050	3.931e-09	61.0	28YVQ@1|root,2ZKNY@2|Bacteria,2HCMJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6618440_0	889378.Spiaf_2477	1.235e-110	366.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
GDHHQS2_k127_6618440_3	656024.FsymDg_3065	7.976e-25	114.0	COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria,4ET0T@85013|Frankiales	201174|Actinobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
GDHHQS2_k127_6618440_1	1552123.EP57_08280	8.771e-65	233.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,26JB4@186820|Listeriaceae	91061|Bacilli	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
GDHHQS2_k127_6618440_2	710686.Mycsm_06369	6.549e-31	130.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,235N2@1762|Mycobacteriaceae	201174|Actinobacteria	NU	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
GDHHQS2_k127_6622418_1	644283.Micau_5409	3.891e-84	284.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9AV@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_6622418_2	521096.Tpau_0914	8.504e-50	192.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
GDHHQS2_k127_6622418_0	525909.Afer_0261	3.344e-164	526.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CNJG@84992|Acidimicrobiia	84992|Acidimicrobiia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
GDHHQS2_k127_6623791_1	1463853.JOHW01000018_gene5021	5.721e-05	56.0	COG3209@1|root,COG3271@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3271@2|Bacteria,COG3291@2|Bacteria,2I35N@201174|Actinobacteria	201174|Actinobacteria	M	sporulation resulting in formation of a cellular spore	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Laminin_G_3,VCBS
GDHHQS2_k127_6623791_0	543632.JOJL01000036_gene3056	1.548e-06	61.0	COG1652@1|root,COG2247@1|root,COG1652@2|Bacteria,COG2247@2|Bacteria,2GR94@201174|Actinobacteria	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M15_4
GDHHQS2_k127_6645803_2	42256.RradSPS_2661	6.541e-34	142.0	COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria,4CQMD@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
GDHHQS2_k127_6645803_0	643648.Slip_1078	4.26e-53	199.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,42JUJ@68298|Syntrophomonadaceae	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
GDHHQS2_k127_6645803_1	65497.JODV01000003_gene4631	3.079e-35	138.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4DXJ9@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
GDHHQS2_k127_6653546_1	1229780.BN381_100088	2.563e-80	272.0	COG3448@1|root,COG3448@2|Bacteria,2IJXV@201174|Actinobacteria	201174|Actinobacteria	T	HPP family	-	-	-	-	-	-	-	-	-	-	-	-	HPP
GDHHQS2_k127_6653546_0	1380393.JHVP01000006_gene4070	2.449e-82	286.0	COG1404@1|root,COG1404@2|Bacteria,2IAS7@201174|Actinobacteria,4ERYY@85013|Frankiales	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
GDHHQS2_k127_6656463_0	1313172.YM304_13960	3.135e-159	516.0	COG1643@1|root,COG1643@2|Bacteria,2GMAW@201174|Actinobacteria	201174|Actinobacteria	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
GDHHQS2_k127_6656463_1	404589.Anae109_1775	1.276e-150	487.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,42ZD0@68525|delta/epsilon subdivisions,2WU4P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
GDHHQS2_k127_6673950_4	1267533.KB906737_gene1986	6.875e-31	123.0	COG1136@1|root,COG1136@2|Bacteria,3Y412@57723|Acidobacteria,2JIJG@204432|Acidobacteriia	204432|Acidobacteriia	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
GDHHQS2_k127_6673950_3	1283299.AUKG01000003_gene577	7.424e-33	137.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4CQ60@84995|Rubrobacteria	84995|Rubrobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
GDHHQS2_k127_6673950_0	756272.Plabr_3475	5.606e-49	181.0	COG0193@1|root,COG0193@2|Bacteria,2IZXT@203682|Planctomycetes	203682|Planctomycetes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
GDHHQS2_k127_6673950_2	1463861.JNXE01000010_gene341	1.266e-43	163.0	COG0346@1|root,COG0346@2|Bacteria,2IKKR@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_6673950_1	392499.Swit_4220	3.716e-44	163.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2K01R@204457|Sphingomonadales	204457|Sphingomonadales	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
GDHHQS2_k127_6674810_0	1380390.JIAT01000010_gene3879	4.069e-277	857.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4CSGY@84995|Rubrobacteria	84995|Rubrobacteria	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
GDHHQS2_k127_6676286_2	880072.Desac_0224	2.042e-05	46.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2MQZ1@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Amino-transferase class IV	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
GDHHQS2_k127_6676286_0	1209984.BN978_02837	9.062e-25	115.0	COG2050@1|root,COG2050@2|Bacteria,2GKY1@201174|Actinobacteria,238HG@1762|Mycobacteriaceae	201174|Actinobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
GDHHQS2_k127_6676286_3	340099.Teth39_1973	0.0008791	47.0	COG0179@1|root,COG0179@2|Bacteria,1UZ6U@1239|Firmicutes,24GY9@186801|Clostridia,42HY4@68295|Thermoanaerobacterales	186801|Clostridia	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
GDHHQS2_k127_6683724_2	593750.Metfor_2502	6.975e-14	78.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota,2N9SE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
GDHHQS2_k127_6683724_1	446469.Sked_07280	7.021e-38	155.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
GDHHQS2_k127_6683724_0	1123023.JIAI01000034_gene4123	2.379e-56	216.0	COG0154@1|root,COG0154@2|Bacteria,2GN7F@201174|Actinobacteria,4DZAM@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase,DUF3225
GDHHQS2_k127_6689274_1	1123023.JIAI01000002_gene5013	2.294e-150	484.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4DX6S@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K08167	-	M00713,M00714	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3	-	-	MFS_1
GDHHQS2_k127_6689274_2	1120950.KB892708_gene4533	5.189e-22	98.0	COG1917@1|root,COG1917@2|Bacteria,2GXFT@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6689274_0	465541.ATCJ01000005_gene6087	2.918e-172	552.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
GDHHQS2_k127_6695495_2	1120936.KB907219_gene3066	2.569e-05	47.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4EFM0@85012|Streptosporangiales	201174|Actinobacteria	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
GDHHQS2_k127_6695495_0	1313172.YM304_28200	8.626e-100	342.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
GDHHQS2_k127_6695495_1	1265505.ATUG01000001_gene4622	5.385e-29	120.0	COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,42T59@68525|delta/epsilon subdivisions,2WPMV@28221|Deltaproteobacteria,2MKE0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	NUDIX domain	-	-	3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
GDHHQS2_k127_6709241_0	743718.Isova_2747	1.798e-64	232.0	COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4F3EM@85017|Promicromonosporaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	1.14.14.5	ko:K04091	ko00920,map00920	-	R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
GDHHQS2_k127_6709241_1	323261.Noc_0230	3.839e-60	220.0	COG3055@1|root,COG3055@2|Bacteria,1QSB4@1224|Proteobacteria,1S2EP@1236|Gammaproteobacteria,1WZIK@135613|Chromatiales	135613|Chromatiales	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_6
GDHHQS2_k127_6726814_2	525909.Afer_1547	3.241e-134	436.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CMWQ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
GDHHQS2_k127_6726814_4	2045.KR76_19190	1.687e-46	173.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4DQCD@85009|Propionibacteriales	201174|Actinobacteria	E	Acetolactate synthase	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
GDHHQS2_k127_6726814_1	1242864.D187_003304	2.063e-138	448.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2YU99@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
GDHHQS2_k127_6726814_0	1485545.JQLW01000009_gene114	6.21e-149	486.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria	1224|Proteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
GDHHQS2_k127_6726814_3	649831.L083_0064	1.771e-110	372.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4D9X6@85008|Micromonosporales	201174|Actinobacteria	S	Transporter associated domain	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
GDHHQS2_k127_6726814_5	1122622.ATWJ01000008_gene2615	2.633e-13	73.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4FE4K@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
GDHHQS2_k127_6739839_0	656024.FsymDg_3257	1.885e-45	174.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4ESEC@85013|Frankiales	201174|Actinobacteria	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
GDHHQS2_k127_6739839_1	1313172.YM304_17230	0.0001078	46.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4CP4J@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
GDHHQS2_k127_6752097_3	263358.VAB18032_08820	1.433e-29	122.0	COG1846@1|root,COG1846@2|Bacteria,2GUE0@201174|Actinobacteria,4DGI4@85008|Micromonosporales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
GDHHQS2_k127_6752097_1	1441629.PCH70_20930	2.308e-55	206.0	COG0697@1|root,COG0697@2|Bacteria,1P38S@1224|Proteobacteria,1SZQH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS2_k127_6752097_0	690850.Desaf_2499	1.491e-68	239.0	COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
GDHHQS2_k127_6752097_2	298655.KI912266_gene2771	3.478e-40	160.0	28KBH@1|root,2Z9YH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6752097_4	1157634.KB912956_gene1845	3.973e-11	73.0	2C9XM@1|root,32RQ6@2|Bacteria,2IF5U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6752097_5	324925.Ppha_0843	2.889e-07	53.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
GDHHQS2_k127_6778234_1	561175.KB894102_gene1110	7.529e-42	159.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4ENTG@85012|Streptosporangiales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	tdcA	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
GDHHQS2_k127_6778234_0	1313172.YM304_30920	1.159e-93	320.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_6781207_0	1120949.KB903300_gene6251	2.256e-121	401.0	COG0465@1|root,COG0465@2|Bacteria,2I9X7@201174|Actinobacteria,4DM45@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase family M41	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
GDHHQS2_k127_6781207_3	675635.Psed_6539	1.303e-05	55.0	2DDKJ@1|root,32U1Q@2|Bacteria,2IKM0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6781207_1	1122182.KB903813_gene2727	3.874e-50	185.0	COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4DBT1@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the UPF0301 (AlgH) family	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
GDHHQS2_k127_6781207_2	1313172.YM304_14970	3.582e-21	94.0	COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria,4CN9Z@84992|Acidimicrobiia	84992|Acidimicrobiia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
GDHHQS2_k127_6783676_1	886293.Sinac_2320	1.302e-95	321.0	COG1012@1|root,COG1012@2|Bacteria,2IXUZ@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_6783676_3	3712.Bo1g108930.1	2.631e-29	121.0	COG0251@1|root,KOG2317@2759|Eukaryota,37T73@33090|Viridiplantae,3G8RY@35493|Streptophyta	35493|Streptophyta	J	Ribonuclease UK114-like	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
GDHHQS2_k127_6783676_2	1229780.BN381_100107	9.373e-37	146.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,3UWKW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	S	Iron-sulphur cluster biosynthesis	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
GDHHQS2_k127_6783676_0	1313172.YM304_38460	9.912e-111	371.0	COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2H1YI@201174|Actinobacteria,4CNPI@84992|Acidimicrobiia	84992|Acidimicrobiia	F	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
GDHHQS2_k127_6787148_3	635013.TherJR_0182	2.036e-85	297.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,2613S@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
GDHHQS2_k127_6787148_0	110319.CF8_3166	3.05e-166	532.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4DPWS@85009|Propionibacteriales	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
GDHHQS2_k127_6787148_7	28042.GU90_04220	8.541e-09	66.0	COG2919@1|root,COG2919@2|Bacteria,2GQH7@201174|Actinobacteria,4E5EA@85010|Pseudonocardiales	201174|Actinobacteria	D	Septum formation initiator	divIC	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
GDHHQS2_k127_6787148_5	1123024.AUII01000020_gene3248	9.838e-23	107.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4E2S8@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
GDHHQS2_k127_6787148_4	29306.JOBE01000015_gene1720	8.605e-54	200.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria	201174|Actinobacteria	FP	Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
GDHHQS2_k127_6787148_6	186497.PF1481	4.637e-09	65.0	COG1765@1|root,arCOG03686@2157|Archaea,2XYGU@28890|Euryarchaeota,2447A@183968|Thermococci	183968|Thermococci	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
GDHHQS2_k127_6787148_1	1122622.ATWJ01000002_gene800	1.124e-125	425.0	COG2114@1|root,COG2197@1|root,COG2114@2|Bacteria,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
GDHHQS2_k127_6787148_2	1128421.JAGA01000001_gene2203	3.03e-107	361.0	COG4579@1|root,COG4579@2|Bacteria	2|Bacteria	F	[isocitrate dehydrogenase (NADP+)] phosphatase activity	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
GDHHQS2_k127_6794201_0	685727.REQ_29610	1.017e-25	112.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4FWP3@85025|Nocardiaceae	201174|Actinobacteria	S	Competence protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
GDHHQS2_k127_6794201_1	246197.MXAN_4353	6.13e-10	66.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
GDHHQS2_k127_6798834_1	1170318.PALO_06760	8.6e-29	122.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4DRJ6@85009|Propionibacteriales	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
GDHHQS2_k127_6798834_2	525909.Afer_0772	7.014e-27	115.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4CN91@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Ribosomal L27 protein	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
GDHHQS2_k127_6798834_0	351607.Acel_0758	8.044e-108	366.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4ES3D@85013|Frankiales	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
GDHHQS2_k127_6798834_3	1122609.AUGT01000005_gene1621	6.801e-23	105.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4DNUG@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
GDHHQS2_k127_6806112_2	1120934.KB894424_gene1332	1.016e-58	215.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4DY5T@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigB	GO:0000988,GO:0000990,GO:0001666,GO:0002791,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009410,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GDHHQS2_k127_6806112_1	1278073.MYSTI_07001	1.241e-99	336.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,2YV1U@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
GDHHQS2_k127_6806112_0	58123.JOFJ01000006_gene203	5.109e-149	497.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4EG9Z@85012|Streptosporangiales	201174|Actinobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS2_k127_6806112_3	1283299.AUKG01000003_gene203	7.888e-29	123.0	COG1670@1|root,COG1670@2|Bacteria,2HP6J@201174|Actinobacteria,4CQIP@84995|Rubrobacteria	84995|Rubrobacteria	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
GDHHQS2_k127_6810833_0	43354.JOIJ01000010_gene2477	1.366e-83	291.0	COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4DXQC@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
GDHHQS2_k127_6810833_1	1394178.AWOO02000003_gene2641	1.047e-19	93.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4EHIU@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_6811715_0	525909.Afer_1960	7.493e-168	536.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CMVI@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
GDHHQS2_k127_6811715_2	235909.GK2505	4.7e-26	116.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,1WG1T@129337|Geobacillus	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
GDHHQS2_k127_6811715_1	1121946.AUAX01000006_gene3456	3.881e-32	128.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4DASE@85008|Micromonosporales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
GDHHQS2_k127_6817112_0	1385519.N801_04735	1.811e-62	226.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4FE32@85021|Intrasporangiaceae	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
GDHHQS2_k127_6819111_0	485913.Krac_3100	1.078e-104	348.0	COG0413@1|root,COG0413@2|Bacteria,2G5TQ@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
GDHHQS2_k127_6819111_1	1111069.TCCBUS3UF1_5630	3.308e-19	96.0	COG1430@1|root,COG1430@2|Bacteria,1WJRZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
GDHHQS2_k127_6820148_1	1214101.BN159_4313	4.03e-36	139.0	COG3070@1|root,COG3070@2|Bacteria,2IKKV@201174|Actinobacteria	201174|Actinobacteria	K	TfoX N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
GDHHQS2_k127_6820148_0	391625.PPSIR1_23474	3.986e-36	141.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
GDHHQS2_k127_6820148_4	1122138.AQUZ01000078_gene6116	9.469e-12	71.0	COG3832@1|root,COG3832@2|Bacteria,2IFGN@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_6820148_2	1206101.AZXC01000013_gene930	6.291e-34	132.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
GDHHQS2_k127_6820148_3	345341.KUTG_05764	3.206e-17	83.0	COG3832@1|root,COG3832@2|Bacteria,2GSCI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_6822170_0	1463821.JOGR01000010_gene4038	3.88e-32	137.0	COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria,4EZJM@85014|Glycomycetales	201174|Actinobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9
GDHHQS2_k127_6822170_1	1112212.JH584235_gene3358	6.983e-24	107.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,2K12J@204457|Sphingomonadales	204457|Sphingomonadales	I	synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
GDHHQS2_k127_6823238_1	316274.Haur_2625	6.67e-140	451.0	COG0362@1|root,COG0362@2|Bacteria,2GBID@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
GDHHQS2_k127_6823238_0	1313172.YM304_11100	8.121e-237	758.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4CMSA@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Peptidase family M1 domain	-	-	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
GDHHQS2_k127_6823238_2	1380370.JIBA01000015_gene198	8.879e-45	166.0	COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4FGN6@85021|Intrasporangiaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
GDHHQS2_k127_6823238_3	468556.AQYG01000044_gene3713	2.808e-41	158.0	COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4GBZ1@85026|Gordoniaceae	201174|Actinobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
GDHHQS2_k127_6825481_0	1120934.KB894416_gene4102	2.641e-105	357.0	COG0277@1|root,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4EB8G@85010|Pseudonocardiales	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
GDHHQS2_k127_6825481_1	247490.KSU1_D0049	9.092e-60	220.0	COG2114@1|root,COG2114@2|Bacteria,2IYZI@203682|Planctomycetes	203682|Planctomycetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
GDHHQS2_k127_6827053_0	1120959.ATXF01000009_gene798	3.013e-158	511.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria,4FRFT@85023|Microbacteriaceae	201174|Actinobacteria	I	Acetyl-CoA dehydrogenase C-terminal like	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
GDHHQS2_k127_6827053_1	1304865.JAGF01000001_gene1006	3.969e-39	152.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
GDHHQS2_k127_6831479_1	479433.Caci_5247	2.321e-38	148.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
GDHHQS2_k127_6831479_0	65497.JODV01000003_gene4734	4.267e-59	218.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,4DXG0@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA ligase D DNA polymerase LigD	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
GDHHQS2_k127_6831479_2	1229780.BN381_110051	4.581e-15	81.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
GDHHQS2_k127_6835013_2	37919.EP51_27515	8.222e-16	84.0	28X81@1|root,2ZJ66@2|Bacteria,2HBUK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6835013_1	1382356.JQMP01000001_gene1074	1.617e-83	292.0	COG1804@1|root,COG1804@2|Bacteria,2G7MX@200795|Chloroflexi,27YZQ@189775|Thermomicrobia	189775|Thermomicrobia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
GDHHQS2_k127_6835013_0	644966.Tmar_2129	3.586e-144	470.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,3WCX5@538999|Clostridiales incertae sedis	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
GDHHQS2_k127_6836202_1	700508.D174_17275	2.284e-33	133.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,232MI@1762|Mycobacteriaceae	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
GDHHQS2_k127_6836202_2	1146883.BLASA_2381	8.213e-25	110.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria,4ESTJ@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
GDHHQS2_k127_6836202_0	1122182.KB903825_gene232	3.892e-167	535.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4D8DZ@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
GDHHQS2_k127_6836202_3	552398.HMPREF0866_00522	6.49e-13	68.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,3WIGR@541000|Ruminococcaceae	186801|Clostridia	H	riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
GDHHQS2_k127_6838744_1	405948.SACE_5849	1.767e-11	74.0	COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria,4E3DB@85010|Pseudonocardiales	201174|Actinobacteria	D	Cell division protein FtsQ	ftsQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
GDHHQS2_k127_6838744_0	338963.Pcar_2200	2.911e-31	128.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2WN8T@28221|Deltaproteobacteria,43SVA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
GDHHQS2_k127_6842185_0	497321.C664_17542	7.677e-186	591.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,2KUI9@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_6842185_2	1121019.AUMN01000038_gene23	1.209e-18	90.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
GDHHQS2_k127_6842185_1	1380391.JIAS01000012_gene4124	5.911e-84	293.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria,2JXWG@204441|Rhodospirillales	204441|Rhodospirillales	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652
GDHHQS2_k127_6842185_3	1380355.JNIJ01000007_gene3225	6.121e-11	64.0	COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
GDHHQS2_k127_6842265_0	266117.Rxyl_2410	9.202e-56	205.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
GDHHQS2_k127_6842265_1	1121087.AUCK01000008_gene2310	4.669e-12	75.0	COG0694@1|root,COG0694@2|Bacteria,1UNSR@1239|Firmicutes,4IUP3@91061|Bacilli	91061|Bacilli	O	Scaffold protein Nfu/NifU N terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N
GDHHQS2_k127_6847574_0	526225.Gobs_0079	1.32e-64	238.0	COG0699@1|root,COG0699@2|Bacteria,2GJX9@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
GDHHQS2_k127_6847574_1	521393.JH806633_gene1780	6.644e-42	176.0	COG0699@1|root,COG0699@2|Bacteria,2GM68@201174|Actinobacteria,4D49Y@85005|Actinomycetales	201174|Actinobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N,MMR_HSR1
GDHHQS2_k127_6849628_5	1386089.N865_12190	1.112e-30	132.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4FE2W@85021|Intrasporangiaceae	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
GDHHQS2_k127_6849628_3	1032480.MLP_11920	5.703e-78	265.0	COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria,4DQTX@85009|Propionibacteriales	201174|Actinobacteria	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
GDHHQS2_k127_6849628_0	1380394.JADL01000001_gene3072	3.931e-146	471.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales	204441|Rhodospirillales	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
GDHHQS2_k127_6849628_1	928724.SacglDRAFT_03170	8.677e-126	406.0	COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4E2HG@85010|Pseudonocardiales	201174|Actinobacteria	C	F420-dependent oxidoreductase, MSMEG_2906 family	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_6849628_4	1313172.YM304_09930	1.757e-73	262.0	28TMF@1|root,2ZFV1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6849628_7	485915.Dret_1630	7.257e-15	78.0	2DNYP@1|root,32ZTI@2|Bacteria,1N747@1224|Proteobacteria,42XZ1@68525|delta/epsilon subdivisions,2WTGJ@28221|Deltaproteobacteria,2ME5V@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
GDHHQS2_k127_6849628_8	1206739.BAGJ01000212_gene956	4.284e-11	64.0	2F2DM@1|root,33VBA@2|Bacteria,2HHW0@201174|Actinobacteria,4G142@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
GDHHQS2_k127_6849628_2	502025.Hoch_5169	3.703e-105	353.0	COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
GDHHQS2_k127_6849628_6	1041522.MCOL_V219096	1.104e-23	101.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,232KJ@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
GDHHQS2_k127_6856104_5	1238182.C882_4432	9.754e-22	100.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
GDHHQS2_k127_6856104_4	1121380.JNIW01000025_gene728	5.315e-25	109.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
GDHHQS2_k127_6856104_2	1123242.JH636434_gene4803	1.102e-76	267.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
GDHHQS2_k127_6856104_0	525909.Afer_1089	1.5e-112	376.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4CMVV@84992|Acidimicrobiia	84992|Acidimicrobiia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
GDHHQS2_k127_6856104_1	1210045.ALNP01000023_gene2928	3.854e-101	342.0	COG4143@1|root,COG4143@2|Bacteria,2GMWD@201174|Actinobacteria	201174|Actinobacteria	H	ABC transporter, periplasmic binding protein, thiB subfamily	thiB	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
GDHHQS2_k127_6856104_3	1210045.ALNP01000023_gene2929	1.218e-61	222.0	COG1178@1|root,COG1178@2|Bacteria,2GKDH@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Fe3 transport system permease component	thiP	-	-	ko:K02011,ko:K02063	ko02010,map02010	M00190,M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.19	-	-	BPD_transp_1
GDHHQS2_k127_6857295_1	1487953.JMKF01000006_gene5651	4.556e-31	127.0	COG3238@1|root,COG3238@2|Bacteria	2|Bacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
GDHHQS2_k127_6857295_0	1449976.KALB_314	2.071e-105	351.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4DXD0@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
GDHHQS2_k127_6858369_0	240016.ABIZ01000001_gene989	1.17e-121	401.0	COG1640@1|root,COG1640@2|Bacteria,46SX0@74201|Verrucomicrobia,2ITJ3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	4-alpha-glucanotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_77
GDHHQS2_k127_6858369_1	1238182.C882_0824	8.478e-71	248.0	COG4106@1|root,COG4106@2|Bacteria,1Q2Y3@1224|Proteobacteria,2TU5T@28211|Alphaproteobacteria,2JS7E@204441|Rhodospirillales	204441|Rhodospirillales	S	trans-aconitate	tam	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_23,Methyltransf_25
GDHHQS2_k127_6863249_2	1120950.KB892745_gene2858	3.601e-22	99.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4DU81@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_6863249_0	1246995.AFR_22615	1.57e-248	782.0	COG0465@1|root,COG0465@2|Bacteria,2H5KC@201174|Actinobacteria,4DM46@85008|Micromonosporales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
GDHHQS2_k127_6863249_1	502025.Hoch_6605	1.329e-42	164.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2YX9H@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase beta thumb	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
GDHHQS2_k127_6876312_1	1445613.JALM01000005_gene1198	3.369e-05	54.0	COG1457@1|root,COG1457@2|Bacteria,2GKZN@201174|Actinobacteria,4DYXJ@85010|Pseudonocardiales	201174|Actinobacteria	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
GDHHQS2_k127_6876312_0	357808.RoseRS_1121	5.106e-102	342.0	COG2141@1|root,COG2141@2|Bacteria,2G5MF@200795|Chloroflexi,376CU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM luciferase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
GDHHQS2_k127_6882118_0	292459.STH590	1.448e-210	661.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes	1239|Firmicutes	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
GDHHQS2_k127_6882118_1	391625.PPSIR1_08217	7.16e-50	183.0	COG0057@1|root,COG0057@2|Bacteria,1N2N1@1224|Proteobacteria	1224|Proteobacteria	G	Glyceraldehyde-3-phosphate dehydrogenase	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
GDHHQS2_k127_6892720_4	1487953.JMKF01000006_gene5651	0.0002896	45.0	COG3238@1|root,COG3238@2|Bacteria	2|Bacteria	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
GDHHQS2_k127_6892720_0	1521187.JPIM01000028_gene1594	8.271e-78	266.0	COG0745@1|root,COG0745@2|Bacteria,2G6JT@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
GDHHQS2_k127_6892720_1	324602.Caur_0875	1.32e-37	153.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,2G60Q@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K02484,ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_6892720_3	1196028.ALEF01000086_gene35	2.818e-12	69.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,4HAU7@91061|Bacilli,4C67Y@84406|Virgibacillus	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
GDHHQS2_k127_6892720_2	1123023.JIAI01000019_gene2184	1.403e-21	97.0	COG2411@1|root,COG2411@2|Bacteria,2IN3A@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6904857_1	1040982.AXAL01000003_gene3538	1.751e-103	343.0	COG1173@1|root,COG1173@2|Bacteria,1R7UQ@1224|Proteobacteria,2U4Q2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
GDHHQS2_k127_6904857_0	1380391.JIAS01000004_gene2986	2.204e-265	834.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPX6@204441|Rhodospirillales	204441|Rhodospirillales	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
GDHHQS2_k127_6904857_2	290340.AAur_0649	6.107e-27	113.0	COG4948@1|root,COG4948@2|Bacteria,2IBIE@201174|Actinobacteria	201174|Actinobacteria	M	Mandelate racemase muconate lactonizing enzyme	-	-	5.5.1.27	ko:K18983	ko00053,map00053	-	R10847	RC03287	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
GDHHQS2_k127_6909517_3	357808.RoseRS_3251	4.01e-06	56.0	COG0325@1|root,COG0325@2|Bacteria,2G6F1@200795|Chloroflexi,375I2@32061|Chloroflexia	32061|Chloroflexia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
GDHHQS2_k127_6909517_0	1121422.AUMW01000017_gene1967	5.52e-12	74.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,261ZS@186807|Peptococcaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
GDHHQS2_k127_6909517_2	1043205.AFYF01000016_gene1034	8.271e-07	54.0	COG0762@1|root,COG0762@2|Bacteria,2GQI1@201174|Actinobacteria,4FHVS@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
GDHHQS2_k127_6909517_1	1304875.JAFZ01000001_gene1405	7.401e-10	68.0	COG3599@1|root,COG3599@2|Bacteria,3TBCR@508458|Synergistetes	508458|Synergistetes	D	DivIVA domain	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
GDHHQS2_k127_6910095_0	357808.RoseRS_0341	2.919e-174	565.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi,376SU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
GDHHQS2_k127_6925324_3	1278073.MYSTI_01273	2.322e-21	102.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria	1224|Proteobacteria	S	protein hemolysin III	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
GDHHQS2_k127_6925324_0	626887.J057_07591	3.612e-115	382.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,465JF@72275|Alteromonadaceae	1236|Gammaproteobacteria	EH	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
GDHHQS2_k127_6925324_1	408672.NBCG_04340	5.485e-113	382.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4DPCG@85009|Propionibacteriales	201174|Actinobacteria	E	Homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
GDHHQS2_k127_6925324_2	570952.ATVH01000015_gene1358	2.025e-98	338.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria,2JPG8@204441|Rhodospirillales	204441|Rhodospirillales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
GDHHQS2_k127_6935488_1	298653.Franean1_0921	3.306e-39	151.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4ERT1@85013|Frankiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
GDHHQS2_k127_6935488_0	882082.SaccyDRAFT_4607	9.065e-117	392.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,4DXG0@85010|Pseudonocardiales	201174|Actinobacteria	L	DNA ligase D DNA polymerase LigD	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
GDHHQS2_k127_6935488_2	367299.JOEE01000002_gene2320	6.176e-32	130.0	COG1633@1|root,COG1633@2|Bacteria,2IHZY@201174|Actinobacteria,4FGQP@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
GDHHQS2_k127_6949014_0	525909.Afer_0486	4.598e-84	293.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4CMP8@84992|Acidimicrobiia	84992|Acidimicrobiia	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
GDHHQS2_k127_6949014_1	469609.HMPREF0847_00173	1.919e-25	111.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,4HATY@91061|Bacilli	91061|Bacilli	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
GDHHQS2_k127_6957321_2	324602.Caur_0124	2.801e-11	67.0	COG4223@1|root,COG4223@2|Bacteria	2|Bacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
GDHHQS2_k127_6957321_0	926550.CLDAP_00290	9.103e-201	636.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	200795|Chloroflexi	G	PFAM carbohydrate kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
GDHHQS2_k127_6957321_1	639283.Snov_2545	1.032e-78	267.0	COG1129@1|root,COG1129@2|Bacteria,1P3ZB@1224|Proteobacteria,2VET1@28211|Alphaproteobacteria,3EZMK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	xylG	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
GDHHQS2_k127_6963733_2	411470.RUMGNA_02951	0.0001254	46.0	2BZDJ@1|root,2ZPU3@2|Bacteria,1W5XA@1239|Firmicutes,255BW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6963733_1	263358.VAB18032_24245	2.176e-07	59.0	2E1T4@1|root,32X2Z@2|Bacteria,2H4V9@201174|Actinobacteria,4DE78@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_6963733_3	525268.HMPREF0308_0203	0.0005081	44.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
GDHHQS2_k127_6963733_0	284031.JNXD01000029_gene1070	4.801e-16	84.0	COG0454@1|root,COG0456@2|Bacteria,2I3DN@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
GDHHQS2_k127_696687_1	469371.Tbis_1492	6.548e-30	123.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4DZVG@85010|Pseudonocardiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
GDHHQS2_k127_696687_0	211114.JOEF01000008_gene1350	1.567e-41	165.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4DXFN@85010|Pseudonocardiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
GDHHQS2_k127_696687_3	1280706.AUJE01000020_gene1358	0.0002958	51.0	COG2206@1|root,COG2206@2|Bacteria,1VEWH@1239|Firmicutes,4H5GI@909932|Negativicutes	909932|Negativicutes	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD
GDHHQS2_k127_696687_2	1089553.Tph_c12940	1.11e-13	74.0	COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,24K3N@186801|Clostridia,42FT9@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM sporulation protein, yteA	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
GDHHQS2_k127_6969088_0	926569.ANT_11030	5.46e-252	813.0	COG1449@1|root,COG4945@1|root,COG1449@2|Bacteria,COG4945@2|Bacteria	2|Bacteria	G	C-terminal binding-module, SLH-like, of glucodextranase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Glucodextran_C,Glyco_hydro_57
GDHHQS2_k127_6969088_1	1122917.KB899669_gene4636	1.517e-113	389.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,4HB67@91061|Bacilli,26QH5@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.133,3.2.1.135,3.2.1.54	ko:K01208	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_N,Malt_amylase_C
GDHHQS2_k127_6969088_2	403833.Pmob_1436	5.698e-19	88.0	COG0419@1|root,COG3833@1|root,COG0419@2|Bacteria,COG3833@2|Bacteria,2GCAW@200918|Thermotogae	200918|Thermotogae	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10110	ko02010,map02010	M00194	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.22	-	iLJ478.TM1202	BPD_transp_1
GDHHQS2_k127_6969592_0	469371.Tbis_0314	2.489e-249	784.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4DXF9@85010|Pseudonocardiales	201174|Actinobacteria	C	ferredoxin oxidoreductase	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
GDHHQS2_k127_6969592_1	1306406.ASHX01000001_gene1138	3.7e-141	456.0	COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria	201174|Actinobacteria	C	Ferredoxin oxidoreductase	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
GDHHQS2_k127_6969592_2	215803.DB30_8770	3.901e-25	107.0	COG0406@1|root,COG0406@2|Bacteria,1RCJE@1224|Proteobacteria,42W6J@68525|delta/epsilon subdivisions,2WSAJ@28221|Deltaproteobacteria,2YZEF@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
GDHHQS2_k127_6980431_0	266117.Rxyl_2466	1.963e-146	471.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CPHH@84995|Rubrobacteria	84995|Rubrobacteria	I	Carboxyl transferase domain	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
GDHHQS2_k127_6980431_1	1123065.ATWL01000010_gene2991	0.0004795	46.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria	201174|Actinobacteria	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
GDHHQS2_k127_699027_2	391735.Veis_0413	6.391e-05	50.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VNCK@28216|Betaproteobacteria,4AFJP@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM peptidase S15	-	-	3.4.14.11	ko:K01281,ko:K06978	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PepX_C,Peptidase_S15
GDHHQS2_k127_699027_0	247634.GPB2148_1717	4.689e-133	433.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RYN7@1236|Gammaproteobacteria,1JBXZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
GDHHQS2_k127_699027_1	1120948.KB903244_gene3141	1.712e-71	252.0	COG0665@1|root,COG0665@2|Bacteria,2I9WR@201174|Actinobacteria,4DZJC@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
GDHHQS2_k127_6990547_0	1183438.GKIL_2303	2.321e-100	330.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria	1117|Cyanobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
GDHHQS2_k127_6990547_1	1379270.AUXF01000001_gene2538	5.084e-76	265.0	COG2321@1|root,COG2321@2|Bacteria,1ZSN1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
GDHHQS2_k127_6990547_3	1382306.JNIM01000001_gene3477	3.708e-06	59.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	rlpA	-	3.5.1.104	ko:K03642,ko:K03791,ko:K22278	-	-	-	-	ko00000,ko01000	-	GH19	-	3D,DPBB_1,Hydrolase_2,LysM
GDHHQS2_k127_6990547_2	272942.RCAP_rcc01838	2.484e-09	59.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,1FBHH@1060|Rhodobacter	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.196,3.2.1.68	ko:K01214,ko:K02438	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02111,R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
GDHHQS2_k127_6998378_1	1040989.AWZU01000046_gene6354	4.616e-15	76.0	COG2333@1|root,COG4995@1|root,COG2333@2|Bacteria,COG4995@2|Bacteria,1RE10@1224|Proteobacteria,2U7SC@28211|Alphaproteobacteria,3K57D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
GDHHQS2_k127_6998378_0	765420.OSCT_1860	3.096e-18	100.0	COG1674@1|root,COG2319@1|root,COG1674@2|Bacteria,COG2319@2|Bacteria,2G86V@200795|Chloroflexi,374S2@32061|Chloroflexia	32061|Chloroflexia	KLT	WD-40 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,WD40
GDHHQS2_k127_700345_1	1382306.JNIM01000001_gene2482	2.517e-45	174.0	COG3662@1|root,COG3662@2|Bacteria,2G8VS@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
GDHHQS2_k127_700345_0	1219084.AP014508_gene1040	6.485e-110	381.0	COG0747@1|root,COG0747@2|Bacteria,2GC1T@200918|Thermotogae	200918|Thermotogae	E	PFAM extracellular solute-binding protein, family 5	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
GDHHQS2_k127_700345_2	1382304.JNIL01000001_gene1692	1.607e-19	101.0	COG0640@1|root,COG0640@2|Bacteria,1TSRQ@1239|Firmicutes,4HBXM@91061|Bacilli,27A54@186823|Alicyclobacillaceae	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
GDHHQS2_k127_7007091_2	298655.KI912266_gene6022	7.559e-13	69.0	COG4585@1|root,COG4585@2|Bacteria,2GJEG@201174|Actinobacteria,4EV50@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
GDHHQS2_k127_7007091_0	298655.KI912266_gene6021	4.522e-95	317.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GDHHQS2_k127_7007091_1	1128427.KB904821_gene361	1.042e-68	246.0	COG2114@1|root,COG2202@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1,4.6.1.2	ko:K01768,ko:K01769,ko:K11959	ko00230,ko02010,ko02025,ko04113,ko04213,map00230,map02010,map02025,map04113,map04213	M00323,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Guanylate_cyc,PAS_4,PAS_9,Peripla_BP_5
GDHHQS2_k127_7010009_1	498761.HM1_1892	4.738e-46	176.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia	186801|Clostridia	M	penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366,ko:K12555	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
GDHHQS2_k127_7010009_0	266117.Rxyl_1283	7.344e-206	651.0	COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CPEB@84995|Rubrobacteria	84995|Rubrobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
GDHHQS2_k127_7021842_1	479435.Kfla_2896	7.866e-15	78.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DR4Q@85009|Propionibacteriales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
GDHHQS2_k127_7021842_0	909613.UO65_4607	1.039e-69	244.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DYBT@85010|Pseudonocardiales	201174|Actinobacteria	L	Tyrosine recombinase XerD	xerD	GO:0008150,GO:0040007	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
GDHHQS2_k127_7031224_1	883.DvMF_3067	2.385e-43	166.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MA1S@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
GDHHQS2_k127_7031224_0	635013.TherJR_2593	1.055e-71	251.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,26144@186807|Peptococcaceae	186801|Clostridia	S	PFAM PHP domain	-	-	3.1.3.97,3.1.4.57	ko:K07053,ko:K20859	ko00440,map00440	-	R00188,R10972,R10973,R11188	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	PHP
GDHHQS2_k127_7037863_0	864069.MicloDRAFT_00044130	2.168e-125	413.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
GDHHQS2_k127_7037863_1	1519464.HY22_08035	8.584e-117	387.0	COG3483@1|root,COG3483@2|Bacteria	2|Bacteria	E	tryptophan 2,3-dioxygenase activity	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11,4.1.1.45	ko:K00453,ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R00678,R04323	RC00356,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
GDHHQS2_k127_7037863_2	292414.TM1040_0391	2.911e-05	49.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,4NBDY@97050|Ruegeria	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
GDHHQS2_k127_7053877_0	66377.JOBH01000006_gene193	1.971e-121	409.0	COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria	201174|Actinobacteria	IQ	Peptidase S15	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
GDHHQS2_k127_7059399_2	1206101.AZXC01000015_gene5076	5.186e-18	88.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria	201174|Actinobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
GDHHQS2_k127_7059399_0	1463879.JOHP01000004_gene6373	1.948e-64	231.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
GDHHQS2_k127_7059399_1	1323361.JPOC01000041_gene3621	1.959e-43	166.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4FVAE@85025|Nocardiaceae	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
GDHHQS2_k127_7077236_4	457429.ABJI02000322_gene887	2.619e-44	164.0	COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria	201174|Actinobacteria	J	ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
GDHHQS2_k127_7077236_0	42256.RradSPS_0323	7.03e-128	418.0	COG1072@1|root,COG1072@2|Bacteria,2GIRR@201174|Actinobacteria,4CTEE@84995|Rubrobacteria	84995|Rubrobacteria	H	Phosphoribulokinase / Uridine kinase family	-	-	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
GDHHQS2_k127_7077236_2	1229780.BN381_450069	1.212e-59	218.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,3UWNJ@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
GDHHQS2_k127_7077236_5	351607.Acel_0234	2.87e-19	97.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
GDHHQS2_k127_7077236_1	686340.Metal_0345	6.565e-113	383.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria,1XE03@135618|Methylococcales	135618|Methylococcales	S	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
GDHHQS2_k127_7077236_3	469371.Tbis_0599	3.571e-56	199.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4E2WQ@85010|Pseudonocardiales	201174|Actinobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
GDHHQS2_k127_7077236_6	1206744.BAGL01000015_gene5867	3.469e-08	55.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4FX39@85025|Nocardiaceae	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
GDHHQS2_k127_7087884_1	561175.KB894094_gene1944	1.79e-87	295.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4EGW8@85012|Streptosporangiales	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
GDHHQS2_k127_7087884_0	696281.Desru_1306	6.537e-105	347.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,260XG@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
GDHHQS2_k127_7096820_4	1323361.JPOC01000048_gene403	5.402e-33	132.0	COG4158@1|root,COG4158@2|Bacteria,2I5FY@201174|Actinobacteria	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
GDHHQS2_k127_7096820_2	469383.Cwoe_3883	4.223e-40	162.0	COG1879@1|root,COG1879@2|Bacteria,2HQ5G@201174|Actinobacteria,4CRNP@84995|Rubrobacteria	84995|Rubrobacteria	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
GDHHQS2_k127_7096820_3	754436.JCM19237_1007	1.285e-36	154.0	COG0006@1|root,COG0006@2|Bacteria,1MVJK@1224|Proteobacteria,1T1D0@1236|Gammaproteobacteria,1XVYG@135623|Vibrionales	135623|Vibrionales	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
GDHHQS2_k127_7096820_0	580327.Tthe_2233	3.258e-126	421.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,42F24@68295|Thermoanaerobacterales	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
GDHHQS2_k127_7096820_1	1035308.AQYY01000001_gene3012	5.134e-123	407.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,2609M@186807|Peptococcaceae	186801|Clostridia	F	TIGRFAM Pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
GDHHQS2_k127_7109006_0	515635.Dtur_1718	1.252e-37	152.0	COG2110@1|root,COG2110@2|Bacteria	2|Bacteria	P	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	Macro
GDHHQS2_k127_7129769_0	525909.Afer_2034	1.036e-30	132.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CN3J@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Putative single-stranded nucleic acids-binding domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,R3H
GDHHQS2_k127_7129769_1	28444.JODQ01000005_gene1216	0.0004135	46.0	COG0357@1|root,COG0357@2|Bacteria,2GM9Z@201174|Actinobacteria,4EIK1@85012|Streptosporangiales	201174|Actinobacteria	M	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
GDHHQS2_k127_7132690_1	928724.SacglDRAFT_01850	3.565e-24	113.0	COG1309@1|root,COG1309@2|Bacteria,2GNDM@201174|Actinobacteria,4E11R@85010|Pseudonocardiales	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_31,TetR_C_6,TetR_N
GDHHQS2_k127_7132690_0	1380386.JIAW01000016_gene6341	3.648e-66	238.0	COG0687@1|root,COG0687@2|Bacteria,2IBEC@201174|Actinobacteria,234YK@1762|Mycobacteriaceae	201174|Actinobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_8
GDHHQS2_k127_7137434_0	1131269.AQVV01000005_gene388	4.879e-54	207.0	COG3639@1|root,COG3639@2|Bacteria	2|Bacteria	P	organic phosphonate transmembrane transporter activity	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
GDHHQS2_k127_71386_2	653733.Selin_0886	4.447e-37	149.0	COG1894@1|root,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
GDHHQS2_k127_71386_1	710421.Mycch_1529	1.564e-41	163.0	COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,2332U@1762|Mycobacteriaceae	201174|Actinobacteria	C	NADH dehydrogenase	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
GDHHQS2_k127_71386_0	1157637.KB892094_gene3038	3.002e-73	252.0	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria	201174|Actinobacteria	I	Pfam SNARE associated Golgi protein	yqjA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
GDHHQS2_k127_7139872_1	479432.Sros_1420	5.826e-106	355.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4EGCZ@85012|Streptosporangiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
GDHHQS2_k127_7139872_0	591001.Acfer_0654	1.572e-107	359.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,4H2N9@909932|Negativicutes	909932|Negativicutes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
GDHHQS2_k127_7139872_2	1229780.BN381_80108	2.95e-96	320.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,3UW73@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	ATPases associated with a variety of cellular activities	ftsE	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
GDHHQS2_k127_7139872_3	42256.RradSPS_1557	5.36e-31	134.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CPSH@84995|Rubrobacteria	84995|Rubrobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
GDHHQS2_k127_714588_0	935839.JAGJ01000034_gene2184	1.199e-50	181.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4F3QJ@85017|Promicromonosporaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
GDHHQS2_k127_7152686_0	937777.Deipe_2178	1.222e-28	130.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771,ko:K08372	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,PG_binding_1,Trypsin_2
GDHHQS2_k127_7162665_0	926550.CLDAP_37580	6.011e-104	353.0	COG0001@1|root,COG0001@2|Bacteria,2G7SS@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_7162665_1	1394178.AWOO02000020_gene7436	1.214e-44	165.0	COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4EFSV@85012|Streptosporangiales	201174|Actinobacteria	E	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	DAO
GDHHQS2_k127_7176847_0	1231391.AMZF01000020_gene2008	1.036e-76	273.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria	1224|Proteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
GDHHQS2_k127_7182476_1	1229780.BN381_80317	7.953e-135	439.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,3UW97@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
GDHHQS2_k127_7182476_0	469371.Tbis_1120	4.585e-158	513.0	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria	201174|Actinobacteria	M	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
GDHHQS2_k127_7182476_2	928724.SacglDRAFT_03153	1.074e-78	266.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4DZ5K@85010|Pseudonocardiales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
GDHHQS2_k127_719346_1	1304275.C41B8_18231	1.056e-24	108.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
GDHHQS2_k127_719346_2	649638.Trad_1061	3.369e-12	68.0	COG0361@1|root,COG0361@2|Bacteria,1WKD7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
GDHHQS2_k127_719346_0	926569.ANT_08060	9.174e-51	186.0	COG0449@1|root,COG0449@2|Bacteria,2G5V6@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar isomerase (SIS)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
GDHHQS2_k127_7198712_1	485913.Krac_9361	7.024e-37	144.0	COG2084@1|root,COG2084@2|Bacteria,2G8RG@200795|Chloroflexi	200795|Chloroflexi	C	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
GDHHQS2_k127_7198712_0	1283283.ATXA01000001_gene686	1.23e-107	361.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF
GDHHQS2_k127_720233_0	316274.Haur_1012	7.128e-51	186.0	COG0454@1|root,COG1246@1|root,COG0456@2|Bacteria,COG1246@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GDHHQS2_k127_720233_1	1068978.AMETH_1398	1.097e-43	170.0	COG3550@1|root,COG3550@2|Bacteria,2GJ1X@201174|Actinobacteria,4E6YS@85010|Pseudonocardiales	201174|Actinobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
GDHHQS2_k127_720233_2	512565.AMIS_66060	7.541e-14	84.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4D8SX@85008|Micromonosporales	201174|Actinobacteria	V	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
GDHHQS2_k127_7207542_1	479433.Caci_8615	1.872e-06	49.0	COG0640@1|root,COG0640@2|Bacteria,2IMCE@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
GDHHQS2_k127_7207542_0	1122175.ATXU01000002_gene1229	1.866e-142	464.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4FM45@85023|Microbacteriaceae	201174|Actinobacteria	J	Ribonuclease E/G family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
GDHHQS2_k127_7208148_2	285535.JOEY01000038_gene2758	1.874e-66	231.0	COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
GDHHQS2_k127_7208148_0	1382306.JNIM01000001_gene2082	6.824e-80	275.0	COG1028@1|root,COG1028@2|Bacteria	1382306.JNIM01000001_gene2082|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_7208148_1	1123024.AUII01000019_gene3963	1.655e-68	235.0	COG1878@1|root,COG1878@2|Bacteria	2|Bacteria	S	arylformamidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
GDHHQS2_k127_7214656_1	1278078.G419_19469	3.362e-54	205.0	COG0657@1|root,COG0657@2|Bacteria,2GTEV@201174|Actinobacteria,4FWNU@85025|Nocardiaceae	201174|Actinobacteria	I	Prolyl oligopeptidase family	lipM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
GDHHQS2_k127_7214656_0	1048339.KB913029_gene2528	2.406e-108	372.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GDHHQS2_k127_7235248_0	452652.KSE_53520	1.557e-315	994.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,2M0Z7@2063|Kitasatospora	201174|Actinobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
GDHHQS2_k127_7240914_1	9606.ENSP00000362710	0.0004293	44.0	KOG3250@1|root,KOG3250@2759|Eukaryota,38CVG@33154|Opisthokonta,3BBG8@33208|Metazoa,3CVK9@33213|Bilateria,48CPT@7711|Chordata,4944U@7742|Vertebrata,3JF8X@40674|Mammalia,35VCP@314146|Euarchontoglires,4MRMQ@9443|Primates,4N9K1@9604|Hominidae	33208|Metazoa	OT	motif in proteasome subunits, Int-6, Nip-1 and TRIP-15	COPS7B	GO:0000003,GO:0000338,GO:0000715,GO:0002009,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006464,GO:0006508,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007276,GO:0007281,GO:0007282,GO:0007283,GO:0007292,GO:0007293,GO:0008150,GO:0008152,GO:0008180,GO:0008283,GO:0008356,GO:0009653,GO:0009888,GO:0009987,GO:0016043,GO:0016333,GO:0019538,GO:0019827,GO:0019953,GO:0022412,GO:0022414,GO:0030154,GO:0030718,GO:0030727,GO:0031647,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0032991,GO:0033554,GO:0034399,GO:0034641,GO:0036099,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0046483,GO:0048134,GO:0048135,GO:0048138,GO:0048140,GO:0048142,GO:0048232,GO:0048468,GO:0048477,GO:0048609,GO:0048646,GO:0048729,GO:0048856,GO:0048869,GO:0050821,GO:0050896,GO:0051276,GO:0051301,GO:0051704,GO:0051716,GO:0060429,GO:0065007,GO:0065008,GO:0070013,GO:0070646,GO:0070647,GO:0071704,GO:0071840,GO:0090304,GO:0098727,GO:1901360,GO:1901564	-	ko:K12180	-	-	-	-	ko00000,ko04121	-	-	-	PCI
GDHHQS2_k127_7240914_0	1157634.KB912943_gene4343	1.696e-34	147.0	COG2211@1|root,COG2211@2|Bacteria,2HH59@201174|Actinobacteria	201174|Actinobacteria	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GDHHQS2_k127_7248124_0	1313172.YM304_26380	1.039e-151	489.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CMS1@84992|Acidimicrobiia	84992|Acidimicrobiia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
GDHHQS2_k127_7248124_2	290397.Adeh_2866	3.083e-46	184.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria	1224|Proteobacteria	C	PFAM FAD linked oxidase domain protein	glcE	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104,ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iETEC_1333.ETEC_3246	FAD-oxidase_C,FAD_binding_4
GDHHQS2_k127_7248124_1	1122917.KB899660_gene1899	1.28e-70	254.0	COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,4HAY9@91061|Bacilli,26U26@186822|Paenibacillaceae	91061|Bacilli	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
GDHHQS2_k127_7248155_1	1386089.N865_19570	1.312e-32	130.0	COG3861@1|root,COG3861@2|Bacteria,2IQ4Y@201174|Actinobacteria,4FHS9@85021|Intrasporangiaceae	201174|Actinobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_7248155_0	889378.Spiaf_0396	1.957e-65	233.0	COG3865@1|root,COG3865@2|Bacteria,2JA3Y@203691|Spirochaetes	203691|Spirochaetes	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
GDHHQS2_k127_7260361_0	485913.Krac_2635	4.488e-79	291.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
GDHHQS2_k127_7260361_1	485913.Krac_2637	1.394e-14	76.0	COG2208@1|root,COG2208@2|Bacteria,2G790@200795|Chloroflexi	200795|Chloroflexi	T	Stage II sporulation E family protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
GDHHQS2_k127_7267691_0	525909.Afer_0713	0.0	1017.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4CMQ1@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
GDHHQS2_k127_7270683_0	1313172.YM304_17800	1.216e-52	195.0	COG2353@1|root,COG2353@2|Bacteria,2IM4N@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
GDHHQS2_k127_7276024_0	1122182.KB903838_gene4197	6.159e-104	343.0	COG0330@1|root,COG0330@2|Bacteria,2GKFP@201174|Actinobacteria,4DD9W@85008|Micromonosporales	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
GDHHQS2_k127_7276024_2	1509405.GV67_25535	2.395e-06	51.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,4BCUB@82115|Rhizobiaceae	28211|Alphaproteobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	MA20_06475	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
GDHHQS2_k127_7276674_1	2002.JOEQ01000025_gene242	4.629e-10	65.0	2E9CG@1|root,333S2@2|Bacteria,2GXQU@201174|Actinobacteria,4EPZY@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIMP
GDHHQS2_k127_7276674_0	928724.SacglDRAFT_00986	6.964e-55	203.0	COG1051@1|root,COG2062@1|root,COG1051@2|Bacteria,COG2062@2|Bacteria,2I2N2@201174|Actinobacteria,4DZW1@85010|Pseudonocardiales	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
GDHHQS2_k127_728447_0	1239962.C943_01261	2.887e-34	138.0	COG2068@1|root,COG2068@2|Bacteria,4NQNF@976|Bacteroidetes,47PUQ@768503|Cytophagia	976|Bacteroidetes	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
GDHHQS2_k127_7285467_1	351607.Acel_2036	1.077e-24	114.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
GDHHQS2_k127_7285467_2	1123321.KB905814_gene1727	6.648e-17	85.0	COG4585@1|root,COG4585@2|Bacteria,2GNPV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
GDHHQS2_k127_7285467_0	1313172.YM304_18210	2.364e-59	228.0	COG2208@1|root,COG3447@1|root,COG2208@2|Bacteria,COG3447@2|Bacteria	2|Bacteria	T	MASE1 domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,HATPase_c,HisKA_3,MASE1,PAS_3,PAS_4,SpoIIE
GDHHQS2_k127_7289495_0	1048339.KB913029_gene3381	3.599e-152	495.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4ERDG@85013|Frankiales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
GDHHQS2_k127_73229_6	1283283.ATXA01000031_gene4211	3.855e-18	83.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4ET6N@85013|Frankiales	201174|Actinobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
GDHHQS2_k127_73229_5	485913.Krac_7038	2.337e-25	111.0	2BVHN@1|root,32SWN@2|Bacteria	2|Bacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
GDHHQS2_k127_73229_4	235985.BBPN01000022_gene2511	3.819e-32	130.0	COG1846@1|root,COG1846@2|Bacteria,2IM92@201174|Actinobacteria,2NIZC@228398|Streptacidiphilus	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
GDHHQS2_k127_73229_0	1120950.KB892776_gene796	3.258e-186	589.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DP99@85009|Propionibacteriales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinP	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
GDHHQS2_k127_73229_1	1122611.KB903961_gene4382	2.996e-58	221.0	COG0346@1|root,COG0346@2|Bacteria,2H18J@201174|Actinobacteria,4EJWZ@85012|Streptosporangiales	201174|Actinobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_73229_2	1156844.KB891804_gene2095	6.5e-45	169.0	COG1670@1|root,COG1670@2|Bacteria,2II7F@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
GDHHQS2_k127_73229_3	743721.Psesu_2271	5.567e-33	130.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X3NP@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
GDHHQS2_k127_734206_0	195250.CM001776_gene3225	3.772e-62	223.0	COG0313@1|root,COG0313@2|Bacteria,1G0IF@1117|Cyanobacteria,1GYBH@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
GDHHQS2_k127_734206_5	1424334.W822_16465	0.0001163	49.0	COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,2VWGX@28216|Betaproteobacteria,3T51Z@506|Alcaligenaceae	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
GDHHQS2_k127_734206_4	720554.Clocl_4023	2.819e-18	88.0	COG2002@1|root,COG2002@2|Bacteria,1VA3H@1239|Firmicutes,24MN7@186801|Clostridia,3WK1W@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator, AbrB family	abrB	-	-	ko:K06284	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin
GDHHQS2_k127_734206_2	867903.ThesuDRAFT_00426	3.559e-47	183.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,3WD1R@538999|Clostridiales incertae sedis	186801|Clostridia	L	TatD related DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
GDHHQS2_k127_734206_1	1210046.B277_00775	5.057e-55	204.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4FE9S@85021|Intrasporangiaceae	201174|Actinobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
GDHHQS2_k127_734206_3	684949.ATTJ01000001_gene1525	1.671e-33	144.0	COG1947@1|root,COG1947@2|Bacteria,1WJXM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
GDHHQS2_k127_73830_0	379066.GAU_2518	4.305e-127	414.0	COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
GDHHQS2_k127_747506_0	1380391.JIAS01000011_gene5426	2.523e-153	497.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_74762_1	479433.Caci_0169	3.582e-102	343.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
GDHHQS2_k127_74762_0	28042.GU90_04150	3.576e-128	425.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4DZZ7@85010|Pseudonocardiales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
GDHHQS2_k127_74762_2	395965.Msil_3515	1.001e-05	55.0	2EMWV@1|root,33FJ4@2|Bacteria,1NI97@1224|Proteobacteria,2UJMC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_74762_3	1120942.AUBM01000001_gene1253	3.995e-05	50.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria,4D3C2@85005|Actinomycetales	201174|Actinobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
GDHHQS2_k127_748821_1	518766.Rmar_2765	7.581e-10	60.0	COG2080@1|root,COG2080@2|Bacteria,4NPTH@976|Bacteroidetes	976|Bacteroidetes	C	PFAM 2Fe-2S binding	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
GDHHQS2_k127_748821_0	502025.Hoch_2000	2.822e-206	653.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
GDHHQS2_k127_75220_3	1003195.SCAT_3207	8.53e-09	68.0	2A4ZY@1|root,30TN1@2|Bacteria,2GMC5@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_75220_2	1416759.AYMR01000001_gene1565	3.881e-55	196.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4FNGY@85023|Microbacteriaceae	201174|Actinobacteria	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
GDHHQS2_k127_75220_0	644283.Micau_5664	4.798e-67	243.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria,4DB1R@85008|Micromonosporales	201174|Actinobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
GDHHQS2_k127_75220_1	1151061.CAJY01000005_gene2676	1.066e-59	216.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
GDHHQS2_k127_78003_0	543632.JOJL01000007_gene5577	9.917e-61	216.0	COG0446@1|root,COG0446@2|Bacteria,2H7WY@201174|Actinobacteria,4D8GY@85008|Micromonosporales	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
GDHHQS2_k127_78003_1	387631.Asulf_01331	1.191e-23	111.0	COG1525@1|root,arCOG08231@1|root,arCOG03192@2157|Archaea,arCOG08231@2157|Archaea,2XTIT@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM nuclease (SNase domain protein)	nuc	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	LTD,SNase
GDHHQS2_k127_787743_2	405948.SACE_5887	8.158e-08	60.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4DYPK@85010|Pseudonocardiales	201174|Actinobacteria	C	FMN-dependent dehydrogenase	lldD	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.1.2.3,1.1.3.15	ko:K00101,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00196,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iNJ661.Rv1872c	FMN_dh
GDHHQS2_k127_787743_1	1122611.KB903944_gene1118	1.331e-51	188.0	COG0716@1|root,COG0716@2|Bacteria,2IQZD@201174|Actinobacteria,4EQE3@85012|Streptosporangiales	201174|Actinobacteria	C	Flavodoxin	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_1,Flavodoxin_5
GDHHQS2_k127_787743_0	565045.NOR51B_2098	1.903e-110	360.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1J5GE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
GDHHQS2_k127_797157_1	994479.GL877883_gene7396	1.215e-43	162.0	COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria,4DXRE@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_797157_0	263358.VAB18032_12840	1.353e-71	252.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria,4D9BH@85008|Micromonosporales	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_797157_3	1415779.JOMH01000001_gene1367	8.78e-24	113.0	COG0657@1|root,COG0657@2|Bacteria,1Q14N@1224|Proteobacteria,1RZIY@1236|Gammaproteobacteria,1X7DR@135614|Xanthomonadales	135614|Xanthomonadales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
GDHHQS2_k127_797157_2	1121859.KB890750_gene558	4.319e-36	149.0	COG0363@1|root,COG0363@2|Bacteria,4NGB9@976|Bacteroidetes,47KK9@768503|Cytophagia	976|Bacteroidetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
GDHHQS2_k127_803663_2	561175.KB894109_gene12	0.0005617	48.0	COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4EHS2@85012|Streptosporangiales	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
GDHHQS2_k127_803663_0	1068978.AMETH_0145	6.152e-107	353.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DY02@85010|Pseudonocardiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS2_k127_803663_1	40571.JOEA01000006_gene4404	6.509e-68	246.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4E1TV@85010|Pseudonocardiales	201174|Actinobacteria	E	pfam abc	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS2_k127_807492_0	28072.Nos7524_1828	1.135e-59	228.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4430,SLH
GDHHQS2_k127_814624_1	288000.BBta_2180	2.324e-10	70.0	COG0500@1|root,COG2226@2|Bacteria,1R92P@1224|Proteobacteria,2VEX9@28211|Alphaproteobacteria,3JWE4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
GDHHQS2_k127_814624_0	1192868.CAIU01000022_gene3200	5.391e-39	153.0	COG0500@1|root,COG2226@2|Bacteria,1RJDW@1224|Proteobacteria,2U4FK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12
GDHHQS2_k127_818691_2	443218.AS9A_3392	1.551e-08	63.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
GDHHQS2_k127_818691_0	498211.CJA_0327	3.056e-62	217.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria,1S3V3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	FJ	deaminase	cdd	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
GDHHQS2_k127_818691_1	649831.L083_6613	5.273e-12	68.0	2F4BF@1|root,33X20@2|Bacteria,2H51G@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_833158_0	511.JT27_12740	2.301e-43	160.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VK1I@28216|Betaproteobacteria,3T2HH@506|Alcaligenaceae	28216|Betaproteobacteria	E	branched-chain amino acid transport	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
GDHHQS2_k127_833158_1	1304284.L21TH_1999	3.286e-35	150.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EAC@31979|Clostridiaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
GDHHQS2_k127_845796_3	1229780.BN381_210097	3.531e-67	235.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,3UW8H@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
GDHHQS2_k127_845796_4	1313172.YM304_37060	4.599e-11	74.0	COG0664@1|root,COG1136@1|root,COG0664@2|Bacteria,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4CNT1@84992|Acidimicrobiia	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,cNMP_binding
GDHHQS2_k127_845796_2	1386089.N865_10495	2.202e-73	258.0	COG1182@1|root,COG1182@2|Bacteria,2I9P0@201174|Actinobacteria,4FID3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
GDHHQS2_k127_845796_1	1313172.YM304_20280	3.504e-92	309.0	28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_845796_5	388739.RSK20926_07938	5.024e-05	56.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
GDHHQS2_k127_847587_0	1146883.BLASA_0206	3.047e-101	342.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4ESAP@85013|Frankiales	201174|Actinobacteria	C	cytochrome P-450	cyp20	-	1.14.14.1	ko:K00493	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko01000	-	-	-	p450
GDHHQS2_k127_847587_2	339860.Msp_0725	0.0001663	53.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2Y2TT@28890|Euryarchaeota,23PBN@183925|Methanobacteria	183925|Methanobacteria	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_847587_1	1382304.JNIL01000001_gene1993	1.049e-31	130.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,2786D@186823|Alicyclobacillaceae	91061|Bacilli	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
GDHHQS2_k127_852100_2	1380347.JNII01000009_gene2003	2.184e-16	83.0	COG2128@1|root,COG2128@2|Bacteria,2HTUG@201174|Actinobacteria,4EUKU@85013|Frankiales	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_852100_0	1144275.COCOR_04930	1.703e-66	233.0	COG4430@1|root,COG4430@2|Bacteria,1NEN6@1224|Proteobacteria,434J2@68525|delta/epsilon subdivisions,2WYWB@28221|Deltaproteobacteria,2Z0SI@29|Myxococcales	28221|Deltaproteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
GDHHQS2_k127_852100_1	367299.JOEE01000004_gene1315	2.785e-31	129.0	COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria,4FGRM@85021|Intrasporangiaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GDHHQS2_k127_85398_1	1313172.YM304_41070	3.28e-77	269.0	COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
GDHHQS2_k127_85398_0	1313172.YM304_41080	6.576e-155	505.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
GDHHQS2_k127_85398_2	1906.SFRA_27555	2.752e-66	240.0	COG1609@1|root,COG1609@2|Bacteria,2GJV7@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
GDHHQS2_k127_85398_3	512565.AMIS_76620	0.0006291	42.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4DAN2@85008|Micromonosporales	201174|Actinobacteria	G	Beta-glucosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
GDHHQS2_k127_860755_0	405948.SACE_2400	7.881e-158	510.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4DZTG@85010|Pseudonocardiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
GDHHQS2_k127_860755_1	1120956.JHZK01000014_gene1732	1.369e-26	118.0	COG0589@1|root,COG0589@2|Bacteria,1PHE6@1224|Proteobacteria,2VCUZ@28211|Alphaproteobacteria,1JQFX@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
GDHHQS2_k127_860755_2	1172188.KB911820_gene2665	2.456e-12	72.0	2BA9G@1|root,323PM@2|Bacteria,2H8DZ@201174|Actinobacteria,4FJE0@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_861914_1	1131269.AQVV01000005_gene388	9.84e-15	84.0	COG3639@1|root,COG3639@2|Bacteria	2|Bacteria	P	organic phosphonate transmembrane transporter activity	phnE	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
GDHHQS2_k127_861914_0	1307761.L21SP2_1483	1.672e-99	330.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
GDHHQS2_k127_866592_1	319003.Bra1253DRAFT_02640	8.464e-16	78.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria,3JVSH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
GDHHQS2_k127_866592_0	1120983.KB894571_gene2469	7.735e-139	455.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,1JPE5@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
GDHHQS2_k127_866592_2	446470.Snas_5609	0.0003059	46.0	COG1609@1|root,COG1609@2|Bacteria,2IK1Q@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein domain	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
GDHHQS2_k127_877281_1	1123240.ATVO01000009_gene856	8.979e-05	50.0	COG3391@1|root,COG3391@2|Bacteria,1R53R@1224|Proteobacteria,2U1FC@28211|Alphaproteobacteria,2K0VC@204457|Sphingomonadales	204457|Sphingomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_877281_0	1172188.KB911829_gene4400	6.319e-50	184.0	COG2128@1|root,COG2128@2|Bacteria,2IG4S@201174|Actinobacteria	201174|Actinobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_889555_1	1112204.GPOL_c50130	2.789e-14	79.0	COG3871@1|root,COG3871@2|Bacteria,2I2TZ@201174|Actinobacteria,4GGW7@85026|Gordoniaceae	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
GDHHQS2_k127_889555_0	1229780.BN381_160003	7.265e-18	86.0	COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,3UWXA@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
GDHHQS2_k127_89871_0	408672.NBCG_04784	1.688e-19	93.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,4DS3B@85009|Propionibacteriales	201174|Actinobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
GDHHQS2_k127_905198_3	106370.Francci3_0422	1.356e-14	75.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4ERCB@85013|Frankiales	201174|Actinobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
GDHHQS2_k127_905198_0	395961.Cyan7425_1966	2.857e-160	520.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,3KGCF@43988|Cyanothece	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.39,1.2.1.79,1.2.1.8	ko:K00128,ko:K00130,ko:K00135,ko:K00138,ko:K00146	ko00010,ko00053,ko00071,ko00250,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00260,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135,M00555	R00264,R00631,R00710,R00711,R00713,R00714,R00904,R01752,R01986,R02401,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_905198_1	314285.KT71_04310	7.66e-54	197.0	COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,1S2MK@1236|Gammaproteobacteria,1J9GE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
GDHHQS2_k127_905198_2	1380347.JNII01000007_gene246	6.878e-36	142.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4ERET@85013|Frankiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
GDHHQS2_k127_926224_4	321955.AAGP01000002_gene3167	3.866e-17	83.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4FARJ@85019|Brevibacteriaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
GDHHQS2_k127_926224_0	1184609.KILIM_052_00110	2.129e-133	444.0	COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4F6FC@85018|Dermatophilaceae	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
GDHHQS2_k127_926224_2	208444.JNYY01000001_gene4974	1.609e-55	200.0	COG0219@1|root,COG0219@2|Bacteria,2IHN9@201174|Actinobacteria,4E2VQ@85010|Pseudonocardiales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	spoU	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
GDHHQS2_k127_926224_1	1313172.YM304_27370	1.456e-91	306.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
GDHHQS2_k127_926224_3	1218075.BAYA01000005_gene1921	3.72e-39	149.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,1K1XZ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.31	ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
GDHHQS2_k127_929114_1	1313172.YM304_09200	5.042e-20	98.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K07552,ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2,2.A.1.2.65	-	-	MFS_1,Sugar_tr,Usp
GDHHQS2_k127_929114_0	1521187.JPIM01000115_gene3356	8.078e-65	228.0	COG0151@1|root,COG0151@2|Bacteria,2G7M4@200795|Chloroflexi,377MJ@32061|Chloroflexia	32061|Chloroflexia	F	ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
GDHHQS2_k127_930218_2	1117647.M5M_06490	5.75e-20	90.0	2CHCP@1|root,32S5R@2|Bacteria,1MZ97@1224|Proteobacteria,1S8M3@1236|Gammaproteobacteria,1JBR0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
GDHHQS2_k127_930218_1	47839.CCAU010000017_gene4086	1.479e-30	125.0	COG0748@1|root,COG0748@2|Bacteria,2IIRE@201174|Actinobacteria,239MD@1762|Mycobacteriaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	ddn	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
GDHHQS2_k127_930218_0	1121272.KB903289_gene4363	6.624e-40	152.0	COG1403@1|root,COG1403@2|Bacteria,2INVR@201174|Actinobacteria	201174|Actinobacteria	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
GDHHQS2_k127_935128_1	1211815.CBYP010000051_gene724	2.232e-24	102.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,4ESXN@85013|Frankiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_935128_0	378806.STAUR_0354	6.899e-35	137.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,431JR@68525|delta/epsilon subdivisions,2WX3E@28221|Deltaproteobacteria,2YXMJ@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
GDHHQS2_k127_935128_2	1229780.BN381_80302	3.779e-13	80.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,3UW6P@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
GDHHQS2_k127_939836_0	351607.Acel_0712	8.13e-166	540.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4ERX1@85013|Frankiales	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
GDHHQS2_k127_939836_1	1380347.JNII01000010_gene2597	2.249e-37	146.0	COG0156@1|root,COG0156@2|Bacteria,2GQWK@201174|Actinobacteria	201174|Actinobacteria	H	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,Aminotran_1_2
GDHHQS2_k127_944793_3	904294.HMPREF9182_0867	4.436e-06	49.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,4HA8S@91061|Bacilli	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
GDHHQS2_k127_944793_1	1121877.JQKF01000004_gene1125	1.296e-119	402.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CMPR@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
GDHHQS2_k127_944793_2	387092.NIS_0423	2.538e-22	104.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2YPXJ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
GDHHQS2_k127_944793_0	1469245.JFBG01000027_gene1501	2.487e-126	414.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
GDHHQS2_k127_949340_0	1120983.KB894571_gene2480	3.603e-48	177.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JPCC@119043|Rhodobiaceae	28211|Alphaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
GDHHQS2_k127_949340_1	83344.XP_007924219.1	1.407e-26	123.0	2CDPA@1|root,2S29V@2759|Eukaryota,39WU4@33154|Opisthokonta,3NYYA@4751|Fungi,3QJS5@4890|Ascomycota,200VS@147541|Dothideomycetes,3MGXS@451867|Dothideomycetidae	4751|Fungi	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	GO:0006582,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009987,GO:0018958,GO:0019438,GO:0019748,GO:0030638,GO:0030640,GO:0042438,GO:0042440,GO:0044237,GO:0044249,GO:0044550,GO:0046148,GO:0046189,GO:0071704,GO:0090487,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901617	-	-	-	-	-	-	-	-	-	-	DUF1100
GDHHQS2_k127_949340_2	439292.Bsel_0470	1.742e-25	113.0	2DQBG@1|root,335T7@2|Bacteria,1UPPJ@1239|Firmicutes	1239|Firmicutes	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	-	-	-	-	-	-	-	-	-	-	GRDB
GDHHQS2_k127_953185_1	1394178.AWOO02000010_gene4176	1.014e-117	394.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4EHPV@85012|Streptosporangiales	201174|Actinobacteria	S	Insulinase (Peptidase family M16)	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
GDHHQS2_k127_953185_4	1032480.MLP_15890	5.301e-64	227.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4DNG2@85009|Propionibacteriales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
GDHHQS2_k127_953185_5	1313172.YM304_36860	6.921e-54	194.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4CN2J@84992|Acidimicrobiia	84992|Acidimicrobiia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
GDHHQS2_k127_953185_6	1121877.JQKF01000015_gene75	2.484e-53	196.0	COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4CMY0@84992|Acidimicrobiia	84992|Acidimicrobiia	O	Tetratricopeptide repeat	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_20,Thioredoxin
GDHHQS2_k127_953185_3	555079.Toce_0017	8.384e-77	267.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,42FSY@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
GDHHQS2_k127_953185_0	398767.Glov_3415	7.229e-153	500.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2WIQ9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
GDHHQS2_k127_953185_7	1380347.JNII01000007_gene113	1.494e-52	189.0	COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria	201174|Actinobacteria	K	arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GDHHQS2_k127_953185_2	1380393.JHVP01000003_gene810	1.743e-77	262.0	COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,4ESXN@85013|Frankiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
GDHHQS2_k127_953185_8	1133849.O3I_010390	9.116e-31	124.0	COG5646@1|root,COG5646@2|Bacteria,2IT4Y@201174|Actinobacteria,4G31R@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
GDHHQS2_k127_955126_2	649638.Trad_0506	1e-43	175.0	COG1132@1|root,COG1132@2|Bacteria,1WISJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS2_k127_955126_0	649638.Trad_0505	1.61e-173	561.0	COG1132@1|root,COG1132@2|Bacteria,1WKZ0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GDHHQS2_k127_955126_3	1869.MB27_30450	1.517e-36	150.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria	201174|Actinobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
GDHHQS2_k127_955126_1	745411.B3C1_11252	6.106e-93	311.0	COG0813@1|root,COG0813@2|Bacteria,1MUW6@1224|Proteobacteria,1RMMA@1236|Gammaproteobacteria,1J9KR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphorylase superfamily	deoD	GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_1997,iB21_1397.B21_04226,iE2348C_1286.E2348C_4682,iEC042_1314.EC042_4881,iECABU_c1320.ECABU_c50190,iECBD_1354.ECBD_3636,iECB_1328.ECB_04260,iECD_1391.ECD_04260,iECED1_1282.ECED1_5255,iECIAI39_1322.ECIAI39_4916,iECNA114_1301.ECNA114_4626,iECO26_1355.ECO26_5590,iECOK1_1307.ECOK1_4950,iECP_1309.ECP_4768,iEcolC_1368.EcolC_3672,iLF82_1304.LF82_0467,iNRG857_1313.NRG857_22170,iPC815.YPO0440,iSFV_1184.SFV_4418,iSF_1195.SF4416,iSFxv_1172.SFxv_4809,iS_1188.S4687,iUMN146_1321.UM146_22680,iUMNK88_1353.UMNK88_5303,iUTI89_1310.UTI89_C5155,ic_1306.c5468	PNP_UDP_1
GDHHQS2_k127_956792_2	1242864.D187_005798	7.603e-09	59.0	COG1546@1|root,COG1546@2|Bacteria,1P6VQ@1224|Proteobacteria,4333J@68525|delta/epsilon subdivisions,2WYBU@28221|Deltaproteobacteria,2Z151@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the CinA family	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_956792_1	146922.JOFU01000067_gene6621	6.915e-10	65.0	COG0645@1|root,COG0645@2|Bacteria	2|Bacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18,AAA_33,CPT
GDHHQS2_k127_956792_0	710696.Intca_1418	4.094e-28	125.0	COG4995@1|root,COG4995@2|Bacteria,2ICQB@201174|Actinobacteria,4FG53@85021|Intrasporangiaceae	201174|Actinobacteria	E	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CHAT,Peptidase_S8,WD40
GDHHQS2_k127_961005_0	1172188.KB911822_gene855	8.945e-86	297.0	COG2141@1|root,COG4639@1|root,COG2141@2|Bacteria,COG4639@2|Bacteria,2GM7W@201174|Actinobacteria,4FG4X@85021|Intrasporangiaceae	201174|Actinobacteria	C	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,Bac_luciferase
GDHHQS2_k127_963373_3	1869.MB27_25355	0.0004132	43.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4DAX3@85008|Micromonosporales	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
GDHHQS2_k127_963373_1	234267.Acid_7358	1.427e-65	229.0	COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria	57723|Acidobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.100,4.2.1.17	ko:K01715,ko:K07537	ko00362,ko00650,ko01100,ko01120,ko01200,ko01220,map00362,map00650,map01100,map01120,map01200,map01220	M00541	R03026,R05597	RC00831,RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
GDHHQS2_k127_963373_2	479434.Sthe_1763	1.391e-16	80.0	COG1024@1|root,COG1024@2|Bacteria,2G6BP@200795|Chloroflexi,27XR0@189775|Thermomicrobia	189775|Thermomicrobia	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
GDHHQS2_k127_963373_0	675635.Psed_0559	2.457e-74	256.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXDJ@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
GDHHQS2_k127_969048_2	561175.KB894093_gene3899	1.848e-08	64.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2IAT1@201174|Actinobacteria,4EH1V@85012|Streptosporangiales	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS
GDHHQS2_k127_969048_0	1370121.AUWS01000020_gene6620	2.508e-22	104.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,236D8@1762|Mycobacteriaceae	201174|Actinobacteria	T	helix_turn_helix, cAMP Regulatory protein	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
GDHHQS2_k127_969048_1	368407.Memar_2494	4.685e-22	99.0	arCOG05253@1|root,arCOG05253@2157|Archaea,2Y4YF@28890|Euryarchaeota,2NB34@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GDHHQS2_k127_970733_0	644966.Tmar_1019	6.655e-179	581.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,3WCEZ@538999|Clostridiales incertae sedis	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
GDHHQS2_k127_970733_6	349161.Dred_1275	1.284e-13	74.0	COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,263AU@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
GDHHQS2_k127_970733_5	1123290.AUDQ01000003_gene628	4.393e-19	93.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,26FH1@186818|Planococcaceae	91061|Bacilli	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
GDHHQS2_k127_970733_1	1122611.KB903982_gene3590	8.28e-71	254.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4EHHU@85012|Streptosporangiales	201174|Actinobacteria	S	DHH family	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
GDHHQS2_k127_970733_3	292459.STH1525	1.77e-62	227.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
GDHHQS2_k127_970733_2	383372.Rcas_1127	3.525e-65	235.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi,374TG@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM riboflavin biosynthesis protein RibF	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
GDHHQS2_k127_970733_4	1121877.JQKF01000004_gene1120	8.366e-34	131.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4CNBM@84992|Acidimicrobiia	84992|Acidimicrobiia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
GDHHQS2_k127_974481_0	1169161.KB897740_gene2271	1.674e-76	260.0	COG0044@1|root,COG0044@2|Bacteria,2IARA@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
GDHHQS2_k127_974481_1	1223523.H340_25237	5.533e-21	101.0	COG0251@1|root,COG0251@2|Bacteria,2IHQ7@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
GDHHQS2_k127_974481_2	1187851.A33M_1394	2.902e-05	50.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GDHHQS2_k127_97884_1	73501.XP_006666504.1	2.1e-06	57.0	COG1020@1|root,KOG1178@2759|Eukaryota,38HAR@33154|Opisthokonta,3NWBA@4751|Fungi,3QME2@4890|Ascomycota,214YZ@147550|Sordariomycetes,3TDYY@5125|Hypocreales	4751|Fungi	Q	Non-ribosomal peptide	-	GO:0006518,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0018130,GO:0019748,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044550,GO:0046483,GO:0050761,GO:0050763,GO:0071704,GO:1900555,GO:1900557,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	AMP-binding,Condensation,PP-binding
GDHHQS2_k127_97884_0	1380386.JIAW01000003_gene442	2.613e-81	286.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,2364D@1762|Mycobacteriaceae	201174|Actinobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
GDHHQS2_k127_985446_2	1313172.YM304_26140	8.938e-11	66.0	COG2104@1|root,COG2104@2|Bacteria,2H07J@201174|Actinobacteria	201174|Actinobacteria	H	ThiS family	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
GDHHQS2_k127_985446_0	867903.ThesuDRAFT_00793	1.649e-102	342.0	COG0037@1|root,COG0037@2|Bacteria,1UB13@1239|Firmicutes,249NH@186801|Clostridia	186801|Clostridia	H	Belongs to the TtcA family	-	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
GDHHQS2_k127_985446_1	351607.Acel_1182	1.116e-73	256.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4ERZF@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
GDHHQS2_k127_994027_3	649638.Trad_0120	1.276e-17	87.0	COG1012@1|root,COG1012@2|Bacteria,1WJDV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
GDHHQS2_k127_994027_0	649638.Trad_0121	3.667e-177	565.0	COG0160@1|root,COG0160@2|Bacteria,1WJ8V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
GDHHQS2_k127_994027_2	1122611.KB903976_gene2754	2.286e-48	177.0	COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,4EIM4@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
GDHHQS2_k127_994027_1	1343740.M271_05635	3.029e-162	525.0	COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria	201174|Actinobacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
GDHHQS2_k127_994465_0	1250006.JHZZ01000001_gene2154	2.074e-126	418.0	COG0561@1|root,COG3408@1|root,COG0561@2|Bacteria,COG3408@2|Bacteria,4NGZM@976|Bacteroidetes,1I02Y@117743|Flavobacteriia	976|Bacteroidetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100,S6PP
## 2563 queries scanned
## Total time (seconds): 279.149288892746
## Rate: 9.18 q/s