## Sat Nov 16 11:58:45 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin5/GNS_1_bin.51.fa -m mmseqs --itype genome -o GNS_1_bin.51 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/GNS_1_bin.51 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs GNS1_k127_1038459_1 671143.DAMO_1629 2.03e-212 669.0 COG0138@1|root,COG0138@2|Bacteria,2NNQ2@2323|unclassified Bacteria 2|Bacteria F Bifunctional purine biosynthesis protein PurH purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS GNS1_k127_1038459_5 671143.DAMO_1628 1.84e-98 325.0 COG0299@1|root,COG0299@2|Bacteria,2NPFD@2323|unclassified Bacteria 2|Bacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2,6.3.2.6,6.3.4.13 ko:K11175,ko:K13713 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04144,R04325,R04326,R04591 RC00026,RC00064,RC00090,RC00162,RC00166,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04225 Formyl_trans_N GNS1_k127_1038459_10 380358.XALC_2529 1.697e-35 141.0 COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,1S826@1236|Gammaproteobacteria,1X74A@135614|Xanthomonadales 135614|Xanthomonadales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin GNS1_k127_1038459_14 380358.XALC_2530 1.451e-25 113.0 2BH75@1|root,32B8F@2|Bacteria,1QB6K@1224|Proteobacteria,1T6QF@1236|Gammaproteobacteria,1X7EX@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - GNS1_k127_1038459_7 671143.DAMO_1022 3.675e-67 231.0 COG1959@1|root,COG1959@2|Bacteria,2NPZX@2323|unclassified Bacteria 2|Bacteria K Transcriptional regulator cymR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 GNS1_k127_1038459_3 671143.DAMO_1023 2.925e-164 520.0 COG0031@1|root,COG0031@2|Bacteria,2NNTU@2323|unclassified Bacteria 2|Bacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK-1 - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP GNS1_k127_1038459_0 671143.DAMO_1024 1.927e-213 666.0 COG0476@1|root,COG1977@1|root,COG0476@2|Bacteria,COG1977@2|Bacteria,2NPX3@2323|unclassified Bacteria 2|Bacteria H ThiF family moeB - 2.7.7.73,2.7.7.80,2.8.1.11 ko:K03148,ko:K03636,ko:K21029,ko:K21147 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF,ThiS GNS1_k127_1038459_13 671143.DAMO_1025 9.148e-27 111.0 COG2391@1|root,COG2391@2|Bacteria 2|Bacteria - - yeeE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07112 - - - - ko00000 - - - Sulf_transp GNS1_k127_1038459_4 671143.DAMO_1025 3.121e-123 398.0 COG2391@1|root,COG2391@2|Bacteria 2|Bacteria - - yeeE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07112 - - - - ko00000 - - - Sulf_transp GNS1_k127_1038459_6 671143.DAMO_1016 2.241e-68 244.0 COG2897@1|root,COG2897@2|Bacteria,2NP8T@2323|unclassified Bacteria 2|Bacteria P Rhodanese Homology Domain rhdA - 2.8.1.1,2.8.1.2,4.1.1.65 ko:K01011,ko:K01613 ko00270,ko00564,ko00920,ko01100,ko01110,ko01120,ko04122,map00270,map00564,map00920,map01100,map01110,map01120,map04122 M00093 R01931,R02055,R03105,R03106 RC00214,RC00299 ko00000,ko00001,ko00002,ko01000 - - - Rhodanese GNS1_k127_1038459_12 671143.DAMO_1026 1.557e-30 124.0 COG0425@1|root,COG0425@2|Bacteria 2|Bacteria O sulfur carrier activity - GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - - - - - - - - - - TusA GNS1_k127_1038459_9 1411123.JQNH01000001_gene2850 1.373e-42 170.0 COG3391@1|root,COG3391@2|Bacteria,1MVXR@1224|Proteobacteria,2TTRF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - - - - - - - - - - Lactonase GNS1_k127_1038459_11 671143.DAMO_1027 3.158e-32 126.0 COG0425@1|root,COG0425@2|Bacteria,2NRUH@2323|unclassified Bacteria 2|Bacteria O Sulfurtransferase TusA sirA - 1.8.7.1 ko:K00392,ko:K04085 ko00920,ko01100,ko01120,ko04122,map00920,map01100,map01120,map04122 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000,ko03016 - - - NIR_SIR,NIR_SIR_ferr,TusA GNS1_k127_1038459_2 671143.DAMO_1028 1.823e-188 591.0 COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria 2|Bacteria E Pyridoxal-phosphate dependent enzyme cysM GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47,6.1.1.16 ko:K01883,ko:K12339,ko:K21148 ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230,map04122 M00021,M00359,M00360 R00897,R03132,R03601,R03650,R04859,R10610 RC00020,RC00055,RC00523,RC02814,RC02821,RC02876,RC03225 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - PALP,tRNA-synt_1e GNS1_k127_1038459_8 671143.DAMO_1029 2.071e-59 211.0 COG1310@1|root,COG1310@2|Bacteria 2|Bacteria S proteolysis - - 2.7.7.80,2.8.1.11,3.13.1.6 ko:K21140,ko:K21147 ko04122,map04122 - R07459,R07461,R11524 RC00043,RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB,Rhodanese,ThiF GNS1_k127_1069300_1 795359.TOPB45_1449 4.237e-69 241.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2GGUA@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding GNS1_k127_1069300_3 671143.DAMO_2366 2.244e-42 160.0 COG2823@1|root,COG2823@2|Bacteria 2|Bacteria S hyperosmotic response - - - - - - - - - - - - BON GNS1_k127_1069300_0 671143.DAMO_2367 1.349e-172 546.0 COG1995@1|root,COG1995@2|Bacteria,2NNWZ@2323|unclassified Bacteria 2|Bacteria H Pyridoxal phosphate biosynthetic protein PdxA pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - DUF1357_C,DUF1537,PdxA GNS1_k127_1069300_2 671143.DAMO_2368 3.985e-49 183.0 COG3678@1|root,COG3678@2|Bacteria,2NRWA@2323|unclassified Bacteria 2|Bacteria NPTU Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - Metal_resist GNS1_k127_1069300_4 640081.Dsui_2768 1.797e-31 128.0 COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria,2KVEP@206389|Rhodocyclales 206389|Rhodocyclales M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 GNS1_k127_1069300_6 1121035.AUCH01000002_gene1539 1.686e-09 65.0 COG2982@1|root,COG2982@2|Bacteria,1NBZ0@1224|Proteobacteria,2VPGQ@28216|Betaproteobacteria,2KVEP@206389|Rhodocyclales 206389|Rhodocyclales M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 GNS1_k127_1077792_6 671143.DAMO_0588 2.295e-101 332.0 COG0498@1|root,COG0498@2|Bacteria,2NP4T@2323|unclassified Bacteria 2|Bacteria E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250 PALP GNS1_k127_1077792_2 671143.DAMO_0587 1.113e-230 720.0 COG0460@1|root,COG0460@2|Bacteria,2NP8S@2323|unclassified Bacteria 2|Bacteria E homoserine dehydrogenase hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1294,iSB619.SA_RS06610 ACT,Homoserine_dh,NAD_binding_3 GNS1_k127_1077792_0 671143.DAMO_0586 0.0 1192.0 COG0046@1|root,COG0046@2|Bacteria,2NNPS@2323|unclassified Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C GNS1_k127_1077792_5 671143.DAMO_0585 1.196e-126 408.0 COG0047@1|root,COG0047@2|Bacteria,2NP46@2323|unclassified Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 GNS1_k127_1077792_7 671143.DAMO_0584 1.036e-33 134.0 COG1828@1|root,COG1828@2|Bacteria,2NQ45@2323|unclassified Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU06460 PurS GNS1_k127_1077792_1 671143.DAMO_0583 3.136e-235 733.0 COG0015@1|root,COG0015@2|Bacteria,2NP0M@2323|unclassified Bacteria 2|Bacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1095,iSB619.SA_RS09895 ADSL_C,Lyase_1 GNS1_k127_1077792_4 671143.DAMO_0582 8.905e-217 677.0 COG0612@1|root,COG0612@2|Bacteria,2NNW3@2323|unclassified Bacteria 2|Bacteria S Belongs to the peptidase M16 family pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Peptidase_M16,Peptidase_M16_C GNS1_k127_1077792_3 671143.DAMO_0581 3.069e-219 684.0 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 GNS1_k127_1087494_3 671143.DAMO_0507 2.573e-61 213.0 COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria 2|Bacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N GNS1_k127_1087494_4 671143.DAMO_0506 2.442e-32 137.0 COG1947@1|root,COG1947@2|Bacteria 2|Bacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 - iYO844.BSU00460 GHMP_kinases_C,GHMP_kinases_N GNS1_k127_1087494_2 671143.DAMO_0505 8.804e-63 226.0 COG1947@1|root,COG1947@2|Bacteria,2NPGM@2323|unclassified Bacteria 2|Bacteria I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 - iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460 GHMP_kinases_C,GHMP_kinases_N GNS1_k127_1087494_0 671143.DAMO_0504 7.098e-89 302.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - DUF4292,LolA GNS1_k127_1087494_1 671143.DAMO_0503 7.865e-74 249.0 COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2NPEN@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - ko:K11935 ko02026,map02026 - - - ko00000,ko00001 - - - TPR_1,TPR_15,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8 GNS1_k127_110220_8 671143.DAMO_0476 2.011e-93 312.0 COG0132@1|root,COG0132@2|Bacteria 2|Bacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 ko:K00652,ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182,R03210,R10124 RC00004,RC00039,RC00868,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - AAA_26 GNS1_k127_110220_9 671143.DAMO_0477 1.227e-87 301.0 COG0797@1|root,COG0797@2|Bacteria,2NPV9@2323|unclassified Bacteria 2|Bacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR GNS1_k127_110220_6 671143.DAMO_2108 5.835e-124 428.0 COG0642@1|root,COG2205@2|Bacteria 671143.DAMO_2108|- T PhoQ Sensor - - - - - - - - - - - - - GNS1_k127_110220_12 671143.DAMO_1267 9.018e-30 138.0 COG0745@1|root,COG0745@2|Bacteria,2NRCR@2323|unclassified Bacteria 2|Bacteria T cheY-homologous receiver domain - - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg GNS1_k127_110220_11 1318628.MARLIPOL_02845 6.607e-32 145.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg GNS1_k127_110220_7 671143.DAMO_0478 1.003e-106 375.0 COG2203@1|root,COG2770@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity vncS - 2.1.1.80,2.7.13.3,3.1.1.61,3.1.3.3 ko:K07315,ko:K07641,ko:K10819,ko:K13924 ko02020,ko02030,map02020,map02030 M00449,M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko03021 - - - CheB_methylest,CheR,CheR_N,GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg GNS1_k127_110220_3 671143.DAMO_0479 5.367e-160 509.0 COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria 2|Bacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg GNS1_k127_110220_4 671143.DAMO_0681 3.174e-144 465.0 COG0739@1|root,COG0739@2|Bacteria,2NPG3@2323|unclassified Bacteria 2|Bacteria M Peptidase family M23 yebA2 - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 GNS1_k127_110220_0 671143.DAMO_0682 0.0 1584.0 COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW GNS1_k127_110220_1 671143.DAMO_0683 4.7e-201 632.0 COG0183@1|root,COG0183@2|Bacteria,2NP9T@2323|unclassified Bacteria 2|Bacteria I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N GNS1_k127_110220_10 671143.DAMO_0685 1.045e-36 141.0 COG1545@1|root,COG1545@2|Bacteria 2|Bacteria I DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc GNS1_k127_110220_5 671143.DAMO_0686 3.124e-133 428.0 COG0388@1|root,COG0388@2|Bacteria,2NPKU@2323|unclassified Bacteria 2|Bacteria S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase GNS1_k127_110220_2 671143.DAMO_0687 3.596e-193 612.0 COG4198@1|root,COG4198@2|Bacteria,2NNV0@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 GNS1_k127_1117924_7 502025.Hoch_3949 2.042e-49 183.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2X3AE@28221|Deltaproteobacteria,2YV4E@29|Myxococcales 28221|Deltaproteobacteria S nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - - - - - - - - - - MoCF_biosynth GNS1_k127_1117924_0 671143.DAMO_2494 4e-323 995.0 COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria 2|Bacteria V ABC transporter MdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran GNS1_k127_1117924_1 671143.DAMO_2495 1.251e-299 928.0 COG1132@1|root,COG1132@2|Bacteria,2NNN4@2323|unclassified Bacteria 2|Bacteria V ABC transporter transmembrane region mdlA - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran GNS1_k127_1117924_2 671143.DAMO_2498 3.455e-199 623.0 COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria 2|Bacteria O Radical SAM superfamily pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM GNS1_k127_1117924_9 1254432.SCE1572_33465 4.59e-35 145.0 COG0819@1|root,COG0819@2|Bacteria 2|Bacteria K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway - - 3.5.99.2 ko:K03707 ko00730,ko01100,map00730,map01100 - R02133,R09993 RC00224,RC00652,RC02832 ko00000,ko00001,ko01000,ko03000 - - - TENA_THI-4 GNS1_k127_1117924_6 1267535.KB906767_gene5148 1.853e-84 290.0 2C1VH@1|root,2Z7Z3@2|Bacteria,3Y4CU@57723|Acidobacteria,2JJ58@204432|Acidobacteriia 204432|Acidobacteriia S 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase - - - - - - - - - - - - Kdo_hydroxy GNS1_k127_1117924_12 1210908.HSB1_17300 1.888e-14 76.0 2C3UT@1|root,2N61V@2157|Archaea,2Y5Q6@28890|Euryarchaeota,240A9@183963|Halobacteria 183963|Halobacteria S TfoX N-terminal domain - - - - - - - - - - - - - GNS1_k127_1117924_15 756272.Plabr_1124 1.727e-06 54.0 COG0745@1|root,COG0745@2|Bacteria 756272.Plabr_1124|- T phosphorelay signal transduction system - - - - - - - - - - - - - GNS1_k127_1117924_14 981327.F925_02365 1.144e-09 68.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,3NIJ0@468|Moraxellaceae 1236|Gammaproteobacteria H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 moeB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.73,2.7.7.80 ko:K03148,ko:K21029 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2482,iECDH1ME8569_1439.ECDH1ME8569_3852,iECDH1ME8569_1439.EcDH1_4002,iECIAI1_1343.ECIAI1_0865,iECIAI39_1322.ECIAI39_4382,iECW_1372.ECW_m0884,iEKO11_1354.EKO11_3059,iETEC_1333.ETEC_0893,iEcDH1_1363.EcDH1_4002,iEcE24377_1341.EcE24377A_0897,iEcSMS35_1347.EcSMS35_0851,iWFL_1372.ECW_m0884 ThiF GNS1_k127_1117924_13 717605.Theco_4075 4.73e-11 73.0 2DZF7@1|root,32V96@2|Bacteria,1VCS6@1239|Firmicutes,4HV9G@91061|Bacilli,2701Z@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - Prok-JAB GNS1_k127_1117924_4 429009.Adeg_0681 1.134e-88 314.0 COG0464@1|root,COG0464@2|Bacteria,1TQTZ@1239|Firmicutes,24C5G@186801|Clostridia 186801|Clostridia O PFAM AAA ATPase central domain protein - - - - - - - - - - - - AAA GNS1_k127_1117924_10 671143.DAMO_2525 1.363e-29 119.0 2EA3B@1|root,3348D@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_1117924_3 671143.DAMO_2526 5.629e-139 451.0 COG0648@1|root,COG0648@2|Bacteria,2NNN3@2323|unclassified Bacteria 2|Bacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 GNS1_k127_1117924_11 118173.KB235914_gene3038 9.253e-25 113.0 COG2802@1|root,COG2802@2|Bacteria,1G0PB@1117|Cyanobacteria,1H7IY@1150|Oscillatoriales 1117|Cyanobacteria S PFAM ATP-dependent protease La (LON) domain lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - LON_substr_bdg GNS1_k127_1117924_8 383372.Rcas_2147 1.486e-36 153.0 COG1184@1|root,COG1184@2|Bacteria,2G9CC@200795|Chloroflexi,3762Q@32061|Chloroflexia 32061|Chloroflexia J Belongs to the eIF-2B alpha beta delta subunits family - - - ko:K03680 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - IF-2B GNS1_k127_1117924_5 671143.DAMO_2527 2.468e-88 295.0 COG2884@1|root,COG2884@2|Bacteria,2NP95@2323|unclassified Bacteria 2|Bacteria D ATPases associated with a variety of cellular activities ftsE GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - ko:K09811,ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran GNS1_k127_1177349_3 671143.DAMO_0002 2.928e-44 162.0 COG0451@1|root,COG0451@2|Bacteria,2NPZU@2323|unclassified Bacteria 2|Bacteria M Male sterility protein dfrA - 1.1.1.219,5.1.3.26 ko:K00091,ko:K19997 - - - - ko00000,ko01000 - - - Epimerase GNS1_k127_1177349_4 1128421.JAGA01000002_gene1811 1.309e-16 84.0 COG2050@1|root,COG2050@2|Bacteria,2NRYC@2323|unclassified Bacteria 2|Bacteria Q Domain of unknown function (DUF4442) paaI - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT GNS1_k127_1177349_1 1120973.AQXL01000127_gene2744 9.219e-116 382.0 COG0492@1|root,COG0492@2|Bacteria,1TRPN@1239|Firmicutes,4H9V7@91061|Bacilli,279CW@186823|Alicyclobacillaceae 91061|Bacilli C Ferredoxin--NADP reductase trxB5 - 1.18.1.2,1.19.1.1 ko:K21567 - - - - ko00000,ko01000 - - - Pyr_redox_2 GNS1_k127_1177349_2 330214.NIDE1739 3.6e-84 297.0 COG0534@1|root,COG0534@2|Bacteria 2|Bacteria V drug transmembrane transporter activity norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE GNS1_k127_1177349_0 671143.DAMO_0003 1.509e-118 383.0 COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria 2|Bacteria O Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD GNS1_k127_1182691_2 1382306.JNIM01000001_gene331 5.495e-71 244.0 COG2057@1|root,COG2057@2|Bacteria,2G6MS@200795|Chloroflexi 200795|Chloroflexi I Coenzyme A transferase - - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans GNS1_k127_1182691_3 485913.Krac_2132 7.221e-36 142.0 COG0251@1|root,COG0251@2|Bacteria 2|Bacteria J oxidation-reduction process abmE - - - - - - - - - - - Ribonuc_L-PSP GNS1_k127_1182691_0 671143.DAMO_1298 2.189e-235 734.0 COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_1182691_1 671143.DAMO_1300 3.149e-216 685.0 COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria 2|Bacteria T PhoQ Sensor - - - ko:K21009 ko02025,map02025 - - - ko00000,ko00001 - - - GAF,GAF_2,GAF_3,GGDEF,HATPase_c,HWE_HK,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 GNS1_k127_1215137_3 671143.DAMO_1867 2.326e-148 489.0 COG4191@1|root,COG4191@2|Bacteria,2NR0D@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HDOD,HisKA,Response_reg GNS1_k127_1215137_0 671143.DAMO_1866 1.864e-244 764.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_1215137_6 671143.DAMO_0977 5.584e-44 168.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - 2.1.1.80,3.1.1.61,3.1.3.3 ko:K03413,ko:K07315,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021 - - - HATPase_c,HDOD,HD_5,Response_reg GNS1_k127_1215137_1 671143.DAMO_0978 4.937e-163 520.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - HSP70,Lactonase,Pkinase GNS1_k127_1215137_5 671143.DAMO_0979 5.907e-59 209.0 COG3448@1|root,COG3448@2|Bacteria 2|Bacteria T diguanylate cyclase activity proV - 3.6.3.32 ko:K02000,ko:K04767,ko:K05847,ko:K07168,ko:K09137 ko02010,map02010 M00208,M00209 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - - ABC_tran,BON,CBS,DUF190,HPP GNS1_k127_1215137_9 1122222.AXWR01000019_gene2702 1.434e-26 114.0 COG0517@1|root,COG0517@2|Bacteria,1WMQJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Domain in cystathionine beta-synthase and other proteins. - - - ko:K04767 - - - - ko00000 - - - CBS GNS1_k127_1215137_2 865861.AZSU01000002_gene2932 1.805e-156 503.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae 186801|Clostridia I Belongs to the thiolase family thlA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N GNS1_k127_1215137_7 945713.IALB_1656 6.38e-31 124.0 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD GNS1_k127_1215137_8 1111069.TCCBUS3UF1_16020 3.954e-27 119.0 COG0517@1|root,COG0517@2|Bacteria,1WI6I@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM CBS domain - - - ko:K04767 - - - - ko00000 - - - CBS GNS1_k127_1215137_4 671143.DAMO_0982 7.575e-80 270.0 COG0535@1|root,COG0535@2|Bacteria,2NQVH@2323|unclassified Bacteria 2|Bacteria S Elongator protein 3, MiaB family, Radical SAM pqqE - - ko:K22226,ko:K22227 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM GNS1_k127_1267388_4 671143.DAMO_2258 2.818e-50 188.0 COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria 2|Bacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 GNS1_k127_1267388_0 671143.DAMO_2259 0.0 1030.0 COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria 2|Bacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C GNS1_k127_1267388_2 671143.DAMO_2260 1.977e-159 507.0 COG0142@1|root,COG0142@2|Bacteria,2NP7G@2323|unclassified Bacteria 2|Bacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 - R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt GNS1_k127_1267388_1 671143.DAMO_2261 4.998e-214 681.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT_2 GNS1_k127_1267388_3 671143.DAMO_2262 2.602e-66 237.0 COG0671@1|root,COG0671@2|Bacteria,2NQ8J@2323|unclassified Bacteria 2|Bacteria I Acid phosphatase homologues lpxE - 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K19302 ko00550,ko00564,ko01100,map00550,map00564,map01100 - R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 - - - PAP2 GNS1_k127_1267388_5 1303518.CCALI_02592 5.123e-44 177.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Response_reg,dCache_1 GNS1_k127_1301939_0 671143.DAMO_2558 2.143e-234 733.0 COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria 2|Bacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 GNS1_k127_1372977_3 671143.DAMO_0529 5.537e-122 394.0 COG0081@1|root,COG0081@2|Bacteria,2NNK6@2323|unclassified Bacteria 2|Bacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 GNS1_k127_1372977_7 671143.DAMO_0530 2.828e-55 199.0 COG0244@1|root,COG0244@2|Bacteria,2NPYE@2323|unclassified Bacteria 2|Bacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 GNS1_k127_1372977_6 671143.DAMO_0531 2.034e-55 196.0 COG0222@1|root,COG0222@2|Bacteria,2NPJ4@2323|unclassified Bacteria 2|Bacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N GNS1_k127_1372977_1 671143.DAMO_0532 0.0 2308.0 COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 GNS1_k127_1372977_0 671143.DAMO_0533 0.0 2434.0 COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 GNS1_k127_1372977_5 671143.DAMO_0534 3.286e-69 237.0 COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria 2|Bacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 GNS1_k127_1372977_4 671143.DAMO_0535 3.746e-81 272.0 COG0049@1|root,COG0049@2|Bacteria,2NP7H@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 GNS1_k127_1372977_2 671143.DAMO_0536 0.0 1177.0 COG0480@1|root,COG0480@2|Bacteria,2NNSV@2323|unclassified Bacteria 2|Bacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 GNS1_k127_1372977_8 671143.DAMO_0537 1.233e-19 88.0 COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria 2|Bacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 GNS1_k127_137633_0 671143.DAMO_1133 4.861e-163 521.0 COG3746@1|root,COG3746@2|Bacteria,2NRQ1@2323|unclassified Bacteria 2|Bacteria P phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P GNS1_k127_137633_1 671143.DAMO_1132 1.931e-124 406.0 COG2998@1|root,COG2998@2|Bacteria,2NP4U@2323|unclassified Bacteria 2|Bacteria H PBP superfamily domain tupB - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 GNS1_k127_137633_2 671143.DAMO_1131 7.537e-25 104.0 COG3585@1|root,COG3585@2|Bacteria 2|Bacteria H molybdate ion transport modE GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE GNS1_k127_1381270_0 671143.DAMO_2104 0.0 1072.0 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2NNKI@2323|unclassified Bacteria 2|Bacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - DUF2344,Radical_SAM GNS1_k127_1381270_1 671143.DAMO_2115 6.846e-80 269.0 COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria 2|Bacteria G Major Facilitator Superfamily - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1,Sugar_tr GNS1_k127_1390970_1 671143.DAMO_2909 2.158e-121 395.0 COG1840@1|root,COG1840@2|Bacteria,2NPYA@2323|unclassified Bacteria 2|Bacteria P Bacterial extracellular solute-binding protein fbpA - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - iJN746.PP_4881 SBP_bac_1,SBP_bac_6,SBP_bac_8 GNS1_k127_1390970_4 330214.NIDE1037 1.836e-34 137.0 COG0735@1|root,COG0735@2|Bacteria,3J0UN@40117|Nitrospirae 40117|Nitrospirae P Belongs to the Fur family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR GNS1_k127_1390970_2 1379698.RBG1_1C00001G0711 1.001e-104 359.0 COG0612@1|root,COG0612@2|Bacteria,2NQHV@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) ymxG - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C GNS1_k127_1390970_0 1379698.RBG1_1C00001G0712 2.128e-141 464.0 COG0612@1|root,COG0612@2|Bacteria,2NQPM@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C GNS1_k127_1390970_3 484019.THA_1091 6.345e-58 206.0 COG1704@1|root,COG1704@2|Bacteria,2GCV5@200918|Thermotogae 200918|Thermotogae S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA GNS1_k127_14216_8 555088.DealDRAFT_1940 3.922e-89 302.0 COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,42KNT@68298|Syntrophomonadaceae 186801|Clostridia M Male sterility protein - - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd GNS1_k127_14216_4 1499967.BAYZ01000186_gene3970 3.315e-114 380.0 COG0438@1|root,COG0438@2|Bacteria,2NR2T@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferase 4-like - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 GNS1_k127_14216_7 880073.Calab_2000 5.058e-109 361.0 COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria 2|Bacteria GM NAD(P)H-binding wbpP - 5.1.3.2,5.1.3.7 ko:K01784,ko:K02473 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R00418,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd GNS1_k127_14216_0 1499967.BAYZ01000069_gene1838 9.166e-179 579.0 COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria 2|Bacteria E PFAM asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 GNS1_k127_14216_9 1124780.ANNU01000028_gene955 7.139e-86 298.0 COG0438@1|root,COG0438@2|Bacteria,4NJ6W@976|Bacteroidetes,47N47@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 GNS1_k127_14216_11 1128421.JAGA01000001_gene2248 5.929e-48 186.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 GNS1_k127_14216_1 111780.Sta7437_1070 2.427e-147 479.0 COG0438@1|root,COG0438@2|Bacteria,1G1VE@1117|Cyanobacteria,3VI7K@52604|Pleurocapsales 1117|Cyanobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 GNS1_k127_14216_10 1298865.H978DRAFT_1022 5.179e-52 198.0 COG1216@1|root,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,1S5S5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_14216_2 304371.MCP_1933 1.512e-140 456.0 arCOG07799@1|root,arCOG07799@2157|Archaea 2157|Archaea S Glycosyl transferases group 1 - - - - - - - - - - - - DUF3880,Glyco_trans_1_2,Glycos_transf_2 GNS1_k127_14216_6 521011.Mpal_2193 8.81e-111 371.0 COG0438@1|root,arCOG01403@2157|Archaea 2157|Archaea M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 GNS1_k127_14216_12 349161.Dred_1396 2.453e-47 190.0 COG4627@1|root,COG4627@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 GNS1_k127_14216_13 1121439.dsat_1297 4.245e-44 180.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2WJYJ@28221|Deltaproteobacteria,2M88U@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_14216_5 1469607.KK073768_gene3009 2.07e-111 374.0 COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,1HQWN@1161|Nostocales 1117|Cyanobacteria GM Wzt C-terminal domain - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C GNS1_k127_14216_3 234267.Acid_4640 4.24e-132 427.0 COG1682@1|root,COG1682@2|Bacteria,3Y7JV@57723|Acidobacteria 57723|Acidobacteria GM ABC-2 type transporter - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane GNS1_k127_1543775_2 933262.AXAM01000034_gene1565 1.253e-92 332.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MJAV@213118|Desulfobacterales 28221|Deltaproteobacteria O Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_8,zinc_ribbon_4 GNS1_k127_1543775_1 382464.ABSI01000002_gene4289 4.137e-116 400.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase prsK - - - - - - - - - - - GAF_2,GAF_3,HATPase_c GNS1_k127_1543775_0 382464.ABSI01000002_gene4287 5.071e-161 518.0 COG2204@1|root,COG2204@2|Bacteria,46SFE@74201|Verrucomicrobia,2ITIG@203494|Verrucomicrobiae 2|Bacteria T Bacterial regulatory protein, Fis family atoC - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_1543775_9 111780.Sta7437_3610 1.096e-08 65.0 2DDDJ@1|root,2ZHMG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_1543775_6 1454004.AW11_02523 3.369e-27 119.0 COG3385@1|root,COG3385@2|Bacteria,1QT8J@1224|Proteobacteria,2VP4B@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 GNS1_k127_1543775_4 671143.DAMO_0191 2.795e-49 181.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - GerE,Response_reg GNS1_k127_1543775_3 671143.DAMO_0189 6.572e-69 241.0 COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria 2|Bacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg GNS1_k127_1543775_7 1239962.C943_03122 2.431e-13 74.0 COG3677@1|root,COG3677@2|Bacteria,4NPDE@976|Bacteroidetes,47U28@768503|Cytophagia 976|Bacteroidetes L Transposase, Mutator family - - - - - - - - - - - - HTH_38,Transposase_mut GNS1_k127_1543775_5 671143.DAMO_2147 2.282e-42 156.0 COG0177@1|root,COG0177@2|Bacteria,2NPBI@2323|unclassified Bacteria 2|Bacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD GNS1_k127_1603482_2 643648.Slip_0150 8.491e-137 444.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,42JNX@68298|Syntrophomonadaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind GNS1_k127_1603482_1 671143.DAMO_1656 5.062e-214 670.0 COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria 2|Bacteria M ABC-type transport system involved in lipoprotein release permease component lolC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD GNS1_k127_1603482_3 1232410.KI421414_gene2836 7.326e-75 259.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,43SYM@69541|Desulfuromonadales 28221|Deltaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran GNS1_k127_1603482_0 671143.DAMO_1654 0.0 1453.0 COG0542@1|root,COG0542@2|Bacteria,2NNKN@2323|unclassified Bacteria 2|Bacteria O C-terminal, D2-small domain, of ClpB protein clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR GNS1_k127_1603482_4 671143.DAMO_1653 3.373e-73 250.0 COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria 2|Bacteria M Surface antigen bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA GNS1_k127_1730543_5 671143.DAMO_1566 1.789e-23 101.0 COG0037@1|root,COG0037@2|Bacteria,2NPAZ@2323|unclassified Bacteria 2|Bacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 - - - ATP_bind_3,Pribosyltran,TilS,TilS_C GNS1_k127_1730543_0 671143.DAMO_1565 0.0 1097.0 COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria 2|Bacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 GNS1_k127_1730543_2 671143.DAMO_1564 1.571e-122 404.0 COG0294@1|root,COG0294@2|Bacteria,2NNN7@2323|unclassified Bacteria 2|Bacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS03115 Pterin_bind GNS1_k127_1730543_3 671143.DAMO_1563 2.376e-116 380.0 COG1624@1|root,COG1624@2|Bacteria,2NPQS@2323|unclassified Bacteria 2|Bacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N GNS1_k127_1730543_4 671143.DAMO_1561 1.252e-82 280.0 COG4856@1|root,COG4856@2|Bacteria,2NQ44@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences dacA - - - - - - - - - - - YbbR GNS1_k127_1730543_1 671143.DAMO_1560 1.087e-242 755.0 COG1109@1|root,COG1109@2|Bacteria,2NNWU@2323|unclassified Bacteria 2|Bacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886,iSBO_1134.SBO_3206 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV GNS1_k127_1751430_1 671143.DAMO_0007 1.602e-59 209.0 COG0265@1|root,COG0265@2|Bacteria,2NQPN@2323|unclassified Bacteria 2|Bacteria O Trypsin degP - 1.3.1.74 ko:K08070,ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Trypsin_2 GNS1_k127_1751430_2 671143.DAMO_0039 2.334e-16 80.0 COG3350@1|root,COG3350@2|Bacteria 2|Bacteria T monooxygenase activity - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DJ-1_PfpI,YHS GNS1_k127_1751430_4 1345697.M493_07420 1.11e-05 56.0 298S5@1|root,2ZVWF@2|Bacteria,1V8I3@1239|Firmicutes,4HHTT@91061|Bacilli,1WE67@129337|Geobacillus 91061|Bacilli S Protein of unknown function with PCYCGC motif - - - - - - - - - - - - PCYCGC GNS1_k127_1751430_0 697281.Mahau_1243 4.691e-147 477.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales 186801|Clostridia P Heavy metal transport detoxification protein copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase GNS1_k127_1794443_3 278963.ATWD01000001_gene2187 1.083e-69 248.0 COG3267@1|root,COG3267@2|Bacteria,3Y6P4@57723|Acidobacteria,2JKNX@204432|Acidobacteriia 204432|Acidobacteriia U AAA domain - - - - - - - - - - - - AAA_22 GNS1_k127_1794443_4 1125863.JAFN01000001_gene472 8.639e-39 158.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,42QS3@68525|delta/epsilon subdivisions,2WMX0@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Capsular exopolysaccharide family - - 2.7.10.1 ko:K08252 - - - - ko00000,ko01000 - - - AAA_31,CbiA,ParA GNS1_k127_1794443_1 1125863.JAFN01000001_gene473 3.603e-94 325.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 GNS1_k127_1794443_2 1210884.HG799469_gene14184 6.793e-75 267.0 COG1215@1|root,COG1215@2|Bacteria,2IXZ2@203682|Planctomycetes 203682|Planctomycetes M glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_1794443_0 1267535.KB906767_gene1723 3.505e-151 492.0 COG0677@1|root,COG0677@2|Bacteria,3Y30B@57723|Acidobacteria,2JIIN@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N GNS1_k127_1902753_4 671143.DAMO_3031 9.062e-19 86.0 COG0247@1|root,COG0247@2|Bacteria,2NNU8@2323|unclassified Bacteria 2|Bacteria C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 GNS1_k127_1902753_2 671143.DAMO_3172 1.571e-161 520.0 COG0277@1|root,COG0277@2|Bacteria,2NP55@2323|unclassified Bacteria 2|Bacteria C FAD binding domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 GNS1_k127_1902753_1 671143.DAMO_3173 1.621e-240 753.0 COG0001@1|root,COG0001@2|Bacteria,2NP0W@2323|unclassified Bacteria 2|Bacteria H Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aldolase_II,Aminotran_3 GNS1_k127_1902753_6 324925.Ppha_0394 3.593e-10 64.0 COG0695@1|root,COG0695@2|Bacteria,1FEC4@1090|Chlorobi 1090|Chlorobi O glutaredoxin 2 - - - - - - - - - - - - DUF836 GNS1_k127_1902753_0 671143.DAMO_0001 1.108e-244 761.0 COG0593@1|root,COG0593@2|Bacteria,2NNTK@2323|unclassified Bacteria 2|Bacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N GNS1_k127_1902753_5 272558.10173497 2.202e-10 66.0 COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,4HAV6@91061|Bacilli,1ZCFS@1386|Bacillus 91061|Bacilli S COG0491 Zn-dependent hydrolases, including glyoxylases yqjP - - - - - - - - - - - Lactamase_B GNS1_k127_1902753_3 671143.DAMO_0002 3.127e-146 466.0 COG0451@1|root,COG0451@2|Bacteria,2NPZU@2323|unclassified Bacteria 2|Bacteria M Male sterility protein dfrA - 1.1.1.219,5.1.3.26 ko:K00091,ko:K19997 - - - - ko00000,ko01000 - - - Epimerase GNS1_k127_2059974_3 710111.FraQA3DRAFT_4981 5.382e-70 242.0 COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,4ESIC@85013|Frankiales 201174|Actinobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides cypB - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase GNS1_k127_2059974_6 247490.KSU1_C1239 1.045e-33 135.0 COG2453@1|root,COG2453@2|Bacteria,2J01Y@203682|Planctomycetes 203682|Planctomycetes T Protein-tyrosine phosphatase - - 3.1.3.16,3.1.3.48 ko:K14165 - - - - ko00000,ko01000,ko01009 - - - DSPc GNS1_k127_2059974_1 671143.DAMO_2369 7.985e-170 537.0 COG1234@1|root,COG1234@2|Bacteria,2NPC9@2323|unclassified Bacteria 2|Bacteria S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 GNS1_k127_2059974_5 909663.KI867149_gene3397 7.88e-38 144.0 COG4274@1|root,COG4274@2|Bacteria,1PUJQ@1224|Proteobacteria,42XN6@68525|delta/epsilon subdivisions,2WTHH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S GYD domain - - - - - - - - - - - - GYD GNS1_k127_2059974_4 589924.Ferp_1683 1.611e-60 222.0 COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi 183980|Archaeoglobi E Periplasmic binding protein domain - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 GNS1_k127_2059974_0 671143.DAMO_2372 2.94e-237 743.0 COG0778@1|root,COG0778@2|Bacteria,2NPP2@2323|unclassified Bacteria 2|Bacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase GNS1_k127_2059974_2 671143.DAMO_2373 1.336e-138 442.0 COG1012@1|root,COG1012@2|Bacteria,2NNW6@2323|unclassified Bacteria 2|Bacteria C Aldehyde dehydrogenase family - - 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 - - - Aldedh GNS1_k127_2061335_1 161156.JQKW01000009_gene1576 1.235e-184 611.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GHH0@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N GNS1_k127_2061335_0 671143.DAMO_2645 0.0 1053.0 COG0751@1|root,COG0751@2|Bacteria,2NNWY@2323|unclassified Bacteria 2|Bacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f GNS1_k127_2081957_4 671143.DAMO_2533 8.819e-123 400.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity surA - 5.2.1.8 ko:K02597,ko:K03769,ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3 GNS1_k127_2081957_5 671143.DAMO_2532 1.209e-77 265.0 COG0242@1|root,COG0242@2|Bacteria,2NPNH@2323|unclassified Bacteria 2|Bacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase GNS1_k127_2081957_1 671143.DAMO_2531 4.734e-182 574.0 COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria 2|Bacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Peptidase_M22 GNS1_k127_2081957_0 671143.DAMO_2530 1.335e-240 749.0 COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 GNS1_k127_2081957_2 671143.DAMO_2529 3.221e-147 477.0 COG4942@1|root,COG4942@2|Bacteria,2NPDY@2323|unclassified Bacteria 2|Bacteria D Peptidase family M23 envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 GNS1_k127_2081957_3 671143.DAMO_2528 3.775e-127 416.0 COG2177@1|root,COG2177@2|Bacteria,2NPIM@2323|unclassified Bacteria 2|Bacteria D Belongs to the ABC-4 integral membrane protein family. FtsX subfamily ftsX GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0040011,GO:0042173,GO:0042221,GO:0043207,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0071976,GO:0090529,GO:1902531 - ko:K09811,ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX GNS1_k127_2081957_6 671143.DAMO_2527 7.694e-35 134.0 COG2884@1|root,COG2884@2|Bacteria,2NP95@2323|unclassified Bacteria 2|Bacteria D ATPases associated with a variety of cellular activities ftsE GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - ko:K09811,ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran GNS1_k127_2164897_3 671143.DAMO_1605 6.671e-101 329.0 COG0377@1|root,COG0377@2|Bacteria,2NP84@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 GNS1_k127_2164897_12 1162668.LFE_1798 1.446e-11 66.0 COG1225@1|root,COG1225@2|Bacteria,3J12D@40117|Nitrospirae 40117|Nitrospirae O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA GNS1_k127_2164897_9 926569.ANT_29600 2.064e-28 117.0 COG0695@1|root,COG1225@1|root,COG0695@2|Bacteria,COG1225@2|Bacteria,2G6XD@200795|Chloroflexi 200795|Chloroflexi O Redoxin - - - - - - - - - - - - AhpC-TSA GNS1_k127_2164897_6 485913.Krac_9819 1.944e-51 185.0 2DQBG@1|root,335T7@2|Bacteria,2G96K@200795|Chloroflexi 200795|Chloroflexi C Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - - - - - - - - - - GRDB GNS1_k127_2164897_4 671143.DAMO_1604 8.92e-92 302.0 COG1143@1|root,COG1143@2|Bacteria,2NPQR@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iNJ661.Rv3153 Fer4 GNS1_k127_2164897_8 266117.Rxyl_2863 2.135e-30 124.0 COG0662@1|root,COG0662@2|Bacteria 2|Bacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_1,Cupin_2 GNS1_k127_2164897_5 1265505.ATUG01000001_gene2914 2.141e-73 254.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PNX@68525|delta/epsilon subdivisions,2WK8F@28221|Deltaproteobacteria,2MJU9@213118|Desulfobacterales 28221|Deltaproteobacteria C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG GNS1_k127_2164897_0 1128421.JAGA01000003_gene3367 1.528e-148 485.0 COG1139@1|root,COG1139@2|Bacteria,2NQQF@2323|unclassified Bacteria 2|Bacteria C LUD domain lutB - - ko:K18929 - - - - ko00000 - - iSF_1195.SF0259,iSFxv_1172.SFxv_0274,iS_1188.S0280 DUF3390,Fer4_8,LUD_dom GNS1_k127_2164897_10 530564.Psta_4615 3.938e-27 125.0 COG1556@1|root,COG1556@2|Bacteria 2|Bacteria S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom GNS1_k127_2164897_1 671143.DAMO_1601 5.389e-134 430.0 COG1526@1|root,COG1526@2|Bacteria,2NPF9@2323|unclassified Bacteria 2|Bacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ,NTP_transf_3 GNS1_k127_2164897_2 671143.DAMO_1600 5.093e-118 386.0 COG0613@1|root,COG0613@2|Bacteria,2NPEX@2323|unclassified Bacteria 2|Bacteria S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP GNS1_k127_2164897_7 56780.SYN_00473 3.225e-37 144.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,42TJK@68525|delta/epsilon subdivisions,2WQ0Z@28221|Deltaproteobacteria,2MRWJ@213462|Syntrophobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 GNS1_k127_2164897_13 1118055.CAGU01000035_gene1544 2.013e-08 63.0 COG0476@1|root,COG0476@2|Bacteria,1UYFC@1239|Firmicutes,247UZ@186801|Clostridia,22GVE@1570339|Peptoniphilaceae 186801|Clostridia H Thiamine biosynthesis protein ThiF thiF - 2.7.7.73 ko:K03148 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF,ThiS-like GNS1_k127_2173699_0 671143.DAMO_1179 0.0 1452.0 COG0209@1|root,COG0209@2|Bacteria,2NNVF@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD GNS1_k127_2284914_2 1382356.JQMP01000003_gene1816 9.389e-26 110.0 COG2606@1|root,COG2606@2|Bacteria,2G9C3@200795|Chloroflexi,27YKX@189775|Thermomicrobia 189775|Thermomicrobia S Aminoacyl-tRNA editing domain - - - - - - - - - - - - tRNA_edit GNS1_k127_2284914_0 671143.DAMO_2856 0.0 1930.0 COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria 2|Bacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon GNS1_k127_2284914_1 713586.KB900536_gene123 3.024e-124 412.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1WX6T@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA GNS1_k127_2284914_3 204669.Acid345_0785 2.363e-22 101.0 29ITM@1|root,305QZ@2|Bacteria,3Y4F3@57723|Acidobacteria,2JJ2C@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - GNS1_k127_2284914_4 1122915.AUGY01000008_gene5069 0.0001025 46.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1UYB2@1239|Firmicutes,4HIMD@91061|Bacilli,26TDP@186822|Paenibacillaceae 91061|Bacilli T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc GNS1_k127_2297014_4 246197.MXAN_2799 3.711e-17 86.0 COG0664@1|root,COG3264@1|root,COG0664@2|Bacteria,COG3264@2|Bacteria,1QX62@1224|Proteobacteria,42S57@68525|delta/epsilon subdivisions,2WNY0@28221|Deltaproteobacteria,2YVPP@29|Myxococcales 28221|Deltaproteobacteria MT Mechanosensitive ion channel - - - - - - - - - - - - MS_channel,cNMP_binding GNS1_k127_2297014_3 1079460.ATTQ01000001_gene5575 3.538e-18 91.0 COG1917@1|root,COG1917@2|Bacteria,1RIG6@1224|Proteobacteria,2VG1C@28211|Alphaproteobacteria,4BNFK@82115|Rhizobiaceae 28211|Alphaproteobacteria S Cupin - - - - - - - - - - - - Cupin_2 GNS1_k127_2297014_0 1288963.ADIS_1161 3.316e-90 309.0 COG0667@1|root,COG0667@2|Bacteria,4NEB0@976|Bacteroidetes,47XEA@768503|Cytophagia 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red GNS1_k127_2297014_2 69395.JQLZ01000005_gene3833 3.627e-21 108.0 COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2TS8F@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM NAD-dependent epimerase dehydratase MA20_16995 - 1.1.1.203 ko:K18981 ko00053,map00053 - R10841 RC00066 ko00000,ko00001,ko01000 - - - Epimerase GNS1_k127_2297014_1 1382303.JPOM01000001_gene2362 6.735e-48 192.0 COG4341@1|root,COG4341@2|Bacteria,1QHQD@1224|Proteobacteria,2U1W2@28211|Alphaproteobacteria,2KHXP@204458|Caulobacterales 204458|Caulobacterales S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD GNS1_k127_2332659_5 671143.DAMO_1091 1.936e-18 84.0 COG0163@1|root,COG0163@2|Bacteria,2NR4A@2323|unclassified Bacteria 2|Bacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein GNS1_k127_2332659_1 671143.DAMO_1093 9.585e-109 357.0 COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB GNS1_k127_2332659_4 671143.DAMO_1094 9.498e-56 197.0 COG0848@1|root,COG0848@2|Bacteria,2NPWJ@2323|unclassified Bacteria 2|Bacteria U Biopolymer transport protein ExbD/TolR tolR - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD GNS1_k127_2332659_2 671143.DAMO_1095 9.466e-104 339.0 COG1392@1|root,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria 2|Bacteria P Protein of unknown function DUF47 MA20_27875 - - ko:K02039,ko:K07220 - - - - ko00000 - - - PhoU_div GNS1_k127_2332659_0 1379698.RBG1_1C00001G0364 8.008e-140 451.0 COG0306@1|root,COG0306@2|Bacteria,2NP4R@2323|unclassified Bacteria 2|Bacteria P Phosphate transporter family pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 GNS1_k127_2332659_3 1162668.LFE_1911 7.092e-78 272.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid yhdG_2 - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2,HATPase_c,HisKA,Response_reg GNS1_k127_2384908_2 497964.CfE428DRAFT_2593 7.771e-52 198.0 COG0457@1|root,COG0457@2|Bacteria 497964.CfE428DRAFT_2593|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GNS1_k127_2384908_6 477641.MODMU_4777 5.681e-07 59.0 COG2246@1|root,COG2246@2|Bacteria,2IGKV@201174|Actinobacteria 201174|Actinobacteria S Pfam GtrA-like protein - - - - - - - - - - - - GtrA GNS1_k127_2384908_4 671143.DAMO_0223 7.996e-50 196.0 COG4409@1|root,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2 GNS1_k127_2384908_0 671143.DAMO_0301 5.092e-209 669.0 COG0457@1|root,COG4745@1|root,COG0457@2|Bacteria,COG4745@2|Bacteria,2NQJ6@2323|unclassified Bacteria 2|Bacteria O Tetratricopeptide repeat - - - - - - - - - - - - NHL,PMT_2,TPR_2,TPR_8 GNS1_k127_2384908_1 671143.DAMO_0226 1.562e-137 443.0 COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 arnC - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 GNS1_k127_2384908_3 357808.RoseRS_4060 2.945e-50 203.0 COG4485@1|root,COG4485@2|Bacteria,2G75F@200795|Chloroflexi,3771H@32061|Chloroflexia 32061|Chloroflexia S Bacterial membrane protein YfhO - - - - - - - - - - - - YfhO GNS1_k127_2384908_5 713586.KB900536_gene1112 1.004e-08 57.0 COG4083@1|root,COG4083@2|Bacteria,1RI8D@1224|Proteobacteria,1S812@1236|Gammaproteobacteria,1X10E@135613|Chromatiales 135613|Chromatiales S Transmembrane exosortase (Exosortase_EpsH) - - - - - - - - - - - - Exosortase_EpsH GNS1_k127_2406317_11 398767.Glov_0689 1.737e-32 143.0 COG2885@1|root,COG3047@1|root,COG2885@2|Bacteria,COG3047@2|Bacteria,1P1AB@1224|Proteobacteria 1224|Proteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - BON,OMP_b-brl,OmpA,OmpA_membrane GNS1_k127_2406317_13 443143.GM18_1081 9.611e-32 136.0 COG2885@1|root,COG3047@1|root,COG3485@1|root,COG2885@2|Bacteria,COG3047@2|Bacteria,COG3485@2|Bacteria 2|Bacteria Q protocatechuate 3,4-dioxygenase activity oprF GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03286,ko:K03640,ko:K07275 - - - - ko00000,ko02000 1.B.6,2.C.1.2 - - OMP_b-brl,OmpA,OprF GNS1_k127_2406317_12 671143.DAMO_2211 4.245e-32 130.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 GNS1_k127_2406317_19 1121468.AUBR01000045_gene1790 6.007e-06 51.0 COG5416@1|root,COG5416@2|Bacteria,1VK4W@1239|Firmicutes,24RJX@186801|Clostridia,42HFD@68295|Thermoanaerobacterales 186801|Clostridia S Lipopolysaccharide assembly protein A domain - - - - - - - - - - - - LapA_dom GNS1_k127_2406317_16 243231.GSU1152 9.384e-16 81.0 COG2510@1|root,COG2510@2|Bacteria,1NDZV@1224|Proteobacteria,42V6K@68525|delta/epsilon subdivisions,2WRTX@28221|Deltaproteobacteria,43UXY@69541|Desulfuromonadales 28221|Deltaproteobacteria S EamA-like transporter family - - - - - - - - - - - - EamA GNS1_k127_2406317_4 671143.DAMO_1072 4.569e-61 214.0 COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria 2|Bacteria M Polymer-forming cytoskeletal CP_0328 - - - - - - - - - - - Bactofilin GNS1_k127_2406317_3 671143.DAMO_1071 8.736e-90 301.0 COG1434@1|root,COG1434@2|Bacteria 2|Bacteria S Gram-negative-bacterium-type cell wall biogenesis - - - - - - - - - - - - DUF218 GNS1_k127_2406317_17 1034769.KB910518_gene4012 6.48e-10 65.0 COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,4HNC2@91061|Bacilli,26XID@186822|Paenibacillaceae 91061|Bacilli M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin GNS1_k127_2406317_15 330214.NIDE2765 1.451e-18 98.0 COG4235@1|root,COG4235@2|Bacteria 2|Bacteria O cytochrome complex assembly cycH - 3.4.21.105 ko:K02200,ko:K04018,ko:K19225,ko:K20543,ko:K21007 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01002,ko02000 1.B.55.3 - - TPR_16,TPR_19,TPR_2,TPR_8 GNS1_k127_2406317_0 671143.DAMO_1065 4.373e-303 941.0 COG0318@1|root,COG0318@2|Bacteria,2NQWW@2323|unclassified Bacteria 2|Bacteria IQ AMP-binding enzyme - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,PP-binding GNS1_k127_2406317_5 671143.DAMO_1064 6.926e-55 197.0 COG1950@1|root,COG1950@2|Bacteria,2NQ43@2323|unclassified Bacteria 2|Bacteria S Mycobacterial 4 TMS phage holin, superfamily IV yvlD - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 GNS1_k127_2406317_14 448385.sce4318 1.324e-18 94.0 COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2YVI9@29|Myxococcales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding GNS1_k127_2406317_8 880073.Calab_0981 1.625e-39 161.0 COG0628@1|root,COG0628@2|Bacteria,2NPYJ@2323|unclassified Bacteria 2|Bacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport GNS1_k127_2406317_10 926550.CLDAP_14070 9.041e-37 156.0 COG5542@1|root,COG5542@2|Bacteria,2G72S@200795|Chloroflexi 200795|Chloroflexi S integral membrane protein - - - - - - - - - - - - Mannosyl_trans2 GNS1_k127_2406317_7 1396418.BATQ01000093_gene5897 2.25e-44 171.0 COG0500@1|root,COG0500@2|Bacteria 2|Bacteria Q methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 GNS1_k127_2406317_2 604354.TSIB_2051 8.973e-119 392.0 COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci 183968|Thermococci E Beta-eliminating lyase - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 GNS1_k127_2406317_1 1128421.JAGA01000002_gene1522 6.155e-155 494.0 COG0451@1|root,COG0451@2|Bacteria,2NQVT@2323|unclassified Bacteria 2|Bacteria M Polysaccharide biosynthesis protein - - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784,ko:K13318,ko:K13322,ko:K16439,ko:K19857 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793,M00798,M00799,M00800 R00291,R02984,R06436,R06513,R06629,R11042,R11047 RC00182,RC00261,RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd GNS1_k127_2406317_6 383372.Rcas_0202 1.337e-48 176.0 COG1216@1|root,COG1216@2|Bacteria,2GBIQ@200795|Chloroflexi,374ZU@32061|Chloroflexia 32061|Chloroflexia S PFAM glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_2422182_5 706587.Desti_4336 0.0001086 45.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42QDN@68525|delta/epsilon subdivisions,2WKRW@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran GNS1_k127_2422182_0 644282.Deba_1628 5.116e-214 680.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding GNS1_k127_2422182_3 535289.Dtpsy_2189 4.707e-41 164.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2WEY0@28216|Betaproteobacteria,4AJBU@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - - - - - - - - - - Cytochrom_D1,Lactonase GNS1_k127_2422182_4 671143.DAMO_2263 1.885e-31 126.0 COG3462@1|root,COG3462@2|Bacteria 2|Bacteria S membrane protein (DUF2078) - - - ko:K08982 - - - - ko00000 - - - SHOCT GNS1_k127_2422182_2 309799.DICTH_0708 3.667e-64 224.0 COG1803@1|root,COG1803@2|Bacteria 2|Bacteria G methylglyoxal synthase activity mgsA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992 MGS GNS1_k127_2422182_1 671143.DAMO_2266 7.017e-76 256.0 COG0693@1|root,COG0693@2|Bacteria,2NNMJ@2323|unclassified Bacteria 2|Bacteria S DJ-1/PfpI family pfpI - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI GNS1_k127_2504822_2 1121422.AUMW01000010_gene1155 7.912e-139 448.0 COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,260F1@186807|Peptococcaceae 186801|Clostridia H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS15750 ALAD GNS1_k127_2504822_0 671143.DAMO_2715 4.484e-230 719.0 COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria 2|Bacteria H PFAM aminotransferase class-III hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006083,GO:0006091,GO:0006113,GO:0006520,GO:0006553,GO:0006554,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0015980,GO:0016020,GO:0016054,GO:0016740,GO:0016769,GO:0016853,GO:0016866,GO:0016869,GO:0016999,GO:0017144,GO:0018130,GO:0019438,GO:0019475,GO:0019477,GO:0019665,GO:0019666,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042737,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044464,GO:0046148,GO:0046395,GO:0046440,GO:0046483,GO:0046501,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 2.6.1.111,5.4.3.8 ko:K01845,ko:K21585 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272,R11607 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 GNS1_k127_2504822_5 452637.Oter_2585 1.929e-09 64.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 GNS1_k127_2504822_4 671143.DAMO_2712 5.708e-61 213.0 COG0838@1|root,COG0838@2|Bacteria,2NPTW@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330,ko:K05574 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 GNS1_k127_2504822_3 671143.DAMO_2711 3.72e-75 259.0 COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa GNS1_k127_2504822_1 671143.DAMO_2710 7.778e-162 513.0 COG0649@1|root,COG0649@2|Bacteria,2NNXB@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa GNS1_k127_2552398_0 671143.DAMO_2970 9.375e-320 985.0 COG0322@1|root,COG0322@2|Bacteria,2NNQ4@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N GNS1_k127_2637431_10 671143.DAMO_0645 1.765e-55 195.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GNS1_k127_2637431_6 671143.DAMO_0646 1.53e-122 397.0 COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein ygcR GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - ko:K03521 - - - - ko00000 - - - ETF GNS1_k127_2637431_4 671143.DAMO_0647 1.348e-151 484.0 COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein etfA-5 - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha GNS1_k127_2637431_0 671143.DAMO_0649 2.51e-321 994.0 COG0247@1|root,COG0247@2|Bacteria,2NNXS@2323|unclassified Bacteria 2|Bacteria C Cysteine-rich domain dgcB - - ko:K11473,ko:K21834 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,DUF3483,Fer4_8 GNS1_k127_2637431_1 1382306.JNIM01000001_gene441 7.26e-246 771.0 COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi 200795|Chloroflexi I TIGRFAM methylmalonyl-CoA mutase, large subunit - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase GNS1_k127_2637431_9 880072.Desac_0569 5.672e-58 207.0 COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,42SKV@68525|delta/epsilon subdivisions,2WP2X@28221|Deltaproteobacteria,2MS30@213462|Syntrophobacterales 28221|Deltaproteobacteria I TIGRFAM methylmalonyl-CoA mutase C-terminal domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding GNS1_k127_2637431_2 671143.DAMO_0590 7.989e-206 644.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase yngJ GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 ko:K00248,ko:K11410,ko:K18244 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GNS1_k127_2637431_7 671143.DAMO_0591 5.127e-120 392.0 COG1703@1|root,COG1703@2|Bacteria,2NP56@2323|unclassified Bacteria 2|Bacteria E LAO AO transport system ATPase argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK GNS1_k127_2637431_11 68570.DC74_7296 1.028e-16 84.0 2BUTG@1|root,32Q51@2|Bacteria,2ISEW@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - GNS1_k127_2637431_3 671143.DAMO_0596 5.159e-190 595.0 COG1788@1|root,COG1788@2|Bacteria,2NR4U@2323|unclassified Bacteria 2|Bacteria I Coenzyme A transferase - - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans GNS1_k127_2637431_5 671143.DAMO_0597 4.268e-138 444.0 COG2057@1|root,COG2057@2|Bacteria,2NP63@2323|unclassified Bacteria 2|Bacteria I Coenzyme A transferase - - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans GNS1_k127_2637431_8 439235.Dalk_3804 1.163e-83 281.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NI5@68525|delta/epsilon subdivisions,2WIN8@28221|Deltaproteobacteria,2MPXX@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C GNS1_k127_2670127_2 671143.DAMO_0348 1.437e-37 145.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - GNS1_k127_2670127_1 671143.DAMO_0347 1.219e-177 563.0 28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - GNS1_k127_2670127_0 671143.DAMO_0346 6.075e-180 567.0 COG1070@1|root,COG1070@2|Bacteria,2NP2A@2323|unclassified Bacteria 2|Bacteria G MutL protein - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N,MutL GNS1_k127_280562_1 420662.Mpe_A2085 2.474e-61 220.0 COG5501@1|root,COG5501@2|Bacteria,1PB0I@1224|Proteobacteria,2VNJJ@28216|Betaproteobacteria,1KKPQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Sulphur oxidation protein SoxZ - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY,SoxZ GNS1_k127_280562_0 228410.NE1183 1.526e-250 790.0 COG1404@1|root,COG1404@2|Bacteria,1N6G1@1224|Proteobacteria,2WEPE@28216|Betaproteobacteria,372DX@32003|Nitrosomonadales 28216|Betaproteobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 GNS1_k127_28494_1 671143.DAMO_1388 6.322e-194 610.0 COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria 2|Bacteria E Aminotransferase aspB GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052 RC00006,RC00025 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 GNS1_k127_28494_2 671143.DAMO_1389 4.287e-75 256.0 COG0669@1|root,COG0669@2|Bacteria,2NPDV@2323|unclassified Bacteria 2|Bacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046390,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0053,iSDY_1059.SDY_4064 CTP_transf_like GNS1_k127_28494_3 671143.DAMO_1390 4.712e-69 241.0 COG0742@1|root,COG0742@2|Bacteria,2NPTA@2323|unclassified Bacteria 2|Bacteria L Conserved hypothetical protein 95 rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 GNS1_k127_28494_4 555079.Toce_1035 2.237e-10 65.0 COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,42HIJ@68295|Thermoanaerobacterales 186801|Clostridia J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 GNS1_k127_28494_0 671143.DAMO_1392 3.196e-278 858.0 COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria 2|Bacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS GNS1_k127_2868727_6 671143.DAMO_2468 1.275e-12 68.0 COG0821@1|root,COG0821@2|Bacteria,2NNPV@2323|unclassified Bacteria 2|Bacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430,iJN678.gcpE GcpE GNS1_k127_2868727_1 671143.DAMO_2467 1.111e-196 617.0 COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria 2|Bacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 GNS1_k127_2868727_2 398767.Glov_2714 2.026e-117 396.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2WK14@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom GNS1_k127_2868727_5 671143.DAMO_2462 1.54e-32 130.0 COG2919@1|root,COG2919@2|Bacteria 2|Bacteria D cell cycle divIC - - ko:K05589,ko:K12065,ko:K13052 - - - - ko00000,ko02044,ko03036 3.A.7.11.1 - - DivIC GNS1_k127_2868727_0 671143.DAMO_2461 1.741e-231 724.0 COG1109@1|root,COG1109@2|Bacteria,2NNTH@2323|unclassified Bacteria 2|Bacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III femD - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV GNS1_k127_2868727_7 671143.DAMO_2460 1.898e-05 52.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2NQFC@2323|unclassified Bacteria 2|Bacteria GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III mpg - 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00361,M00362 R00885,R00959,R01057,R01818,R02060,R08639 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3178 Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III GNS1_k127_2868727_8 588581.Cpap_2017 0.0007807 45.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,3WNNI@541000|Ruminococcaceae 186801|Clostridia GJM phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 2.7.7.13,5.4.2.8 ko:K00966,ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00361,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I GNS1_k127_2868727_4 671143.DAMO_2458 1.078e-47 171.0 COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria 2|Bacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 GNS1_k127_2868727_3 671143.DAMO_2457 3.143e-83 278.0 COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria 2|Bacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 GNS1_k127_2930491_8 671143.DAMO_2705 1.045e-27 114.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M GNS1_k127_2930491_0 671143.DAMO_2704 3.573e-249 776.0 COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M GNS1_k127_2930491_7 671143.DAMO_2703 1.072e-30 123.0 COG5336@1|root,COG5336@2|Bacteria,2NRT4@2323|unclassified Bacteria 2|Bacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter atpI - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 GNS1_k127_2930491_2 671143.DAMO_2702 1.009e-129 417.0 COG0356@1|root,COG0356@2|Bacteria,2NPRQ@2323|unclassified Bacteria 2|Bacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A GNS1_k127_2930491_5 671143.DAMO_2701 6.141e-42 157.0 COG0636@1|root,COG0636@2|Bacteria 2|Bacteria C ATP hydrolysis coupled proton transport atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C GNS1_k127_2930491_4 671143.DAMO_2700 1.347e-54 199.0 COG0838@1|root,COG0838@2|Bacteria,2NPTW@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 GNS1_k127_2930491_3 671143.DAMO_2699 1.406e-77 263.0 COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa GNS1_k127_2930491_1 671143.DAMO_2698 7.468e-231 717.0 COG0649@1|root,COG0649@2|Bacteria,2NNWG@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa GNS1_k127_2930491_6 671143.DAMO_2697 4.382e-40 149.0 COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria 2|Bacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3,1.6.99.3 ko:K00334,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - 2Fe-2S_thioredx GNS1_k127_3032281_0 671143.DAMO_1511 2.401e-150 480.0 COG2267@1|root,COG2267@2|Bacteria,2NRVV@2323|unclassified Bacteria 2|Bacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 GNS1_k127_3032281_2 269799.Gmet_2815 7.417e-87 302.0 COG1215@1|root,COG1215@2|Bacteria,1PC79@1224|Proteobacteria,42QYP@68525|delta/epsilon subdivisions,2X6HG@28221|Deltaproteobacteria,43UDX@69541|Desulfuromonadales 28221|Deltaproteobacteria M Glycosyl transferase family group 2 hpnI - 2.4.1.80 ko:K00720 ko00600,ko01100,map00600,map01100 M00066 R01497 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko02000 4.D.1.4 GT21 - Glyco_transf_21 GNS1_k127_3032281_3 1173023.KE650771_gene5176 1.179e-77 269.0 COG3394@1|root,COG3394@2|Bacteria,1G2GK@1117|Cyanobacteria 1117|Cyanobacteria G TIGRFAM hopanoid biosynthesis associated protein HpnK - - - - - - - - - - - - GtrA,YdjC GNS1_k127_3032281_1 671143.DAMO_1512 1.094e-106 353.0 COG1562@1|root,COG1562@2|Bacteria,2NQ19@2323|unclassified Bacteria 2|Bacteria I Squalene/phytoene synthase crtB - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY GNS1_k127_307368_5 671143.DAMO_2068 1.216e-59 209.0 COG2050@1|root,COG2050@2|Bacteria,2NQ0Q@2323|unclassified Bacteria 2|Bacteria Q Thioesterase superfamily - - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - 4HBT GNS1_k127_307368_2 671143.DAMO_2067 1.657e-115 377.0 COG1912@1|root,COG1912@2|Bacteria,2NPI0@2323|unclassified Bacteria 2|Bacteria S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans GNS1_k127_307368_1 671143.DAMO_2066 1.079e-141 456.0 COG0568@1|root,COG0568@2|Bacteria,2NQT5@2323|unclassified Bacteria 2|Bacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoS - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 GNS1_k127_307368_3 671143.DAMO_2065 2.083e-103 341.0 COG2518@1|root,COG2518@2|Bacteria,2NP7E@2323|unclassified Bacteria 2|Bacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT GNS1_k127_307368_4 671143.DAMO_2064 1.324e-96 320.0 COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria 2|Bacteria S (Rhomboid) family - - - - - - - - - - - - Rhomboid GNS1_k127_307368_6 671143.DAMO_2063 1.817e-49 181.0 COG3824@1|root,COG3824@2|Bacteria,2NPZF@2323|unclassified Bacteria 2|Bacteria S Zincin-like metallopeptidase MA20_43655 - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Zincin_1 GNS1_k127_307368_0 671143.DAMO_2062 0.0 1100.0 COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria 2|Bacteria E Threonine synthase - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - LeuA_dimer,PALP GNS1_k127_3134602_6 671143.DAMO_0905 4.349e-21 95.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_3134602_1 1131269.AQVV01000028_gene50 9.716e-182 585.0 COG2804@1|root,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N GNS1_k127_3134602_0 671143.DAMO_2488 2.251e-209 657.0 COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria 2|Bacteria U Type II secretion system (T2SS), protein F xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF GNS1_k127_3134602_5 105559.Nwat_0046 6.725e-25 117.0 COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,1S8YK@1236|Gammaproteobacteria,1X28T@135613|Chromatiales 135613|Chromatiales J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP GNS1_k127_3134602_2 671143.DAMO_2487 4.63e-76 269.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif lspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG GNS1_k127_3134602_3 671143.DAMO_2486 1.814e-72 251.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane xpsH - - ko:K02246,ko:K02457,ko:K02459,ko:K02672,ko:K08084 ko03070,ko05111,map03070,map05111 M00331,M00429 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - GspH,N_methyl GNS1_k127_3134602_4 671143.DAMO_2485 7.005e-46 172.0 COG4967@1|root,COG4967@2|Bacteria 2|Bacteria NU type IV pilus modification protein PilV - - - ko:K02458 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl GNS1_k127_336104_11 671143.DAMO_2258 8.86e-64 220.0 COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria 2|Bacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 GNS1_k127_336104_4 671143.DAMO_2257 1.296e-174 557.0 COG0635@1|root,COG0635@2|Bacteria,2NP4Y@2323|unclassified Bacteria 2|Bacteria H Involved in the biosynthesis of porphyrin-containing compound yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM GNS1_k127_336104_5 671143.DAMO_2256 1.487e-173 549.0 COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria 2|Bacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K03705 - - - - ko00000,ko03000 - - - HTH_DeoR,HrcA,HrcA_DNA-bdg GNS1_k127_336104_10 671143.DAMO_2255 3.169e-73 252.0 COG0576@1|root,COG0576@2|Bacteria,2NPSS@2323|unclassified Bacteria 2|Bacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE GNS1_k127_336104_7 1232410.KI421424_gene1723 1.716e-130 425.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43SEG@69541|Desulfuromonadales 28221|Deltaproteobacteria O DnaJ central domain dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG GNS1_k127_336104_12 1521187.JPIM01000130_gene680 1.165e-49 190.0 COG2264@1|root,COG2264@2|Bacteria,2G69X@200795|Chloroflexi,374X2@32061|Chloroflexia 32061|Chloroflexia J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA GNS1_k127_336104_15 1120985.AUMI01000001_gene2095 0.0001627 48.0 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,4H420@909932|Negativicutes 909932|Negativicutes J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA GNS1_k127_336104_0 671143.DAMO_2253 0.0 1211.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7,3.1.26.4 ko:K02335,ko:K03469 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 GNS1_k127_336104_9 671143.DAMO_2252 3.819e-80 272.0 COG0237@1|root,COG0237@2|Bacteria,2NPMB@2323|unclassified Bacteria 2|Bacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,2.7.7.87 ko:K00859,ko:K07566 ko00770,ko01100,map00770,map01100 M00120 R00130,R10463 RC00002,RC00078,RC00745 ko00000,ko00001,ko00002,ko01000,ko03009,ko03016 - - - CoaE GNS1_k127_336104_1 671143.DAMO_2251 1.497e-265 820.0 COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria 2|Bacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind GNS1_k127_336104_14 671143.DAMO_2250 5.278e-36 139.0 COG0254@1|root,COG0254@2|Bacteria,2NPUV@2323|unclassified Bacteria 2|Bacteria J Binds the 23S rRNA rpmE GO:0008150,GO:0040007 - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 GNS1_k127_336104_3 671143.DAMO_2249 9.07e-179 565.0 COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 GNS1_k127_336104_13 1232410.KI421412_gene110 1.213e-48 188.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WM9R@28221|Deltaproteobacteria,43S3F@69541|Desulfuromonadales 28221|Deltaproteobacteria J Putative RNA methylase family UPF0020 prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_25,Methyltransf_31 GNS1_k127_336104_2 671143.DAMO_2247 2.107e-202 636.0 COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase GNS1_k127_336104_8 671143.DAMO_2246 1.12e-111 364.0 COG0040@1|root,COG0040@2|Bacteria,2NPCD@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG GNS1_k127_336104_6 671143.DAMO_2245 1.274e-150 482.0 COG0141@1|root,COG0141@2|Bacteria,2NNTS@2323|unclassified Bacteria 2|Bacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS14140,iYO844.BSU34910 Histidinol_dh GNS1_k127_3375227_10 552811.Dehly_0163 1.543e-09 62.0 COG1487@1|root,COG1487@2|Bacteria,2G9UG@200795|Chloroflexi 200795|Chloroflexi S PIN domain - - - - - - - - - - - - PIN GNS1_k127_3375227_7 671143.DAMO_2522 2.353e-12 69.0 COG2002@1|root,COG2002@2|Bacteria 2|Bacteria K toxin-antitoxin pair type II binding - - - - - - - - - - - - MazE_antitoxin GNS1_k127_3375227_5 357808.RoseRS_3416 1.094e-23 102.0 COG2026@1|root,COG2026@2|Bacteria,2G9D2@200795|Chloroflexi,377W0@32061|Chloroflexia 32061|Chloroflexia DJ ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin GNS1_k127_3375227_6 357808.RoseRS_3417 7.539e-19 88.0 2EVE4@1|root,33NUJ@2|Bacteria,2G98A@200795|Chloroflexi 200795|Chloroflexi - - - - - - - - - - - - - - - GNS1_k127_3375227_3 1410620.SHLA_45c000850 2.365e-26 110.0 COG3093@1|root,COG3093@2|Bacteria,1NA48@1224|Proteobacteria,2UZZ0@28211|Alphaproteobacteria,4BKF1@82115|Rhizobiaceae 28211|Alphaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 GNS1_k127_3375227_1 426117.M446_7033 4.284e-47 171.0 COG4679@1|root,COG4679@2|Bacteria,1QMSB@1224|Proteobacteria,2UE5S@28211|Alphaproteobacteria,1JVSQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 GNS1_k127_3375227_0 1299327.I546_5558 4.362e-125 409.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,23B0M@1762|Mycobacteriaceae 201174|Actinobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 GNS1_k127_3375227_2 1299327.I546_5559 4.645e-32 128.0 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_28,HTH_29,HTH_32,LZ_Tnp_IS481 GNS1_k127_3375227_9 237368.SCABRO_03146 2.508e-10 64.0 2EMFR@1|root,33F4G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_3375227_4 1499967.BAYZ01000043_gene2306 5.581e-26 110.0 COG2929@1|root,COG2929@2|Bacteria 2|Bacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin GNS1_k127_3375227_8 1330700.JQNC01000001_gene2250 9.747e-12 68.0 COG2026@1|root,COG2026@2|Bacteria,1WN9J@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus DJ ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin GNS1_k127_3375227_11 760568.Desku_0135 0.0007178 45.0 COG4118@1|root,COG4118@2|Bacteria,1W5MC@1239|Firmicutes,255VN@186801|Clostridia 186801|Clostridia D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox GNS1_k127_3458443_3 314230.DSM3645_15690 1.289e-06 52.0 COG0583@1|root,COG0583@2|Bacteria,2IYFV@203682|Planctomycetes 203682|Planctomycetes K COG0583 Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate GNS1_k127_3458443_4 1121904.ARBP01000022_gene3506 0.0004365 52.0 COG1629@1|root,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,47M35@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec GNS1_k127_3458443_2 572480.Arnit_0705 7.143e-09 62.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2YT6X@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T DnaK suppressor protein dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR GNS1_k127_3458443_0 177437.HRM2_08430 7.077e-55 203.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,42Q6W@68525|delta/epsilon subdivisions,2WKMV@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02029,ko:K10002 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 GNS1_k127_3458443_1 1123229.AUBC01000025_gene4464 1.491e-30 124.0 COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2TRAT@28211|Alphaproteobacteria,3JVGT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Binding-protein-dependent transport system inner membrane component gltJ - - ko:K10003 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 GNS1_k127_3468755_0 671143.DAMO_1408 8.798e-264 848.0 COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria 2|Bacteria U Secretin and TonB N terminus short domain pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N GNS1_k127_3468755_3 671143.DAMO_1410 6.779e-67 235.0 COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria 2|Bacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO GNS1_k127_3468755_4 671143.DAMO_1411 1.143e-52 192.0 COG3166@1|root,COG3166@2|Bacteria 2|Bacteria NU PFAM Fimbrial assembly family protein pilN - - ko:K02662,ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN GNS1_k127_3468755_1 671143.DAMO_1412 6.303e-145 467.0 COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria 2|Bacteria NU Type IV pilus assembly protein PilM; pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 GNS1_k127_3468755_6 1379270.AUXF01000004_gene3145 0.0002999 44.0 COG4726@1|root,COG4726@2|Bacteria,1ZUS8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Pilus assembly protein PilX - - - - - - - - - - - - - GNS1_k127_3473062_3 671143.DAMO_0060 1.817e-214 668.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2NNS8@2323|unclassified Bacteria 2|Bacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168,ko:K07479 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom GNS1_k127_3473062_1 671143.DAMO_0061 8.041e-240 746.0 COG1206@1|root,COG1206@2|Bacteria,2NS4B@2323|unclassified Bacteria 2|Bacteria J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA GNS1_k127_3473062_6 671143.DAMO_0070 7.55e-150 483.0 COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria 2|Bacteria L Phage integrase, N-terminal SAM-like domain xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase GNS1_k127_3473062_9 671143.DAMO_0071 1.417e-82 280.0 COG5405@1|root,COG5405@2|Bacteria,2NP72@2323|unclassified Bacteria 2|Bacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome GNS1_k127_3473062_0 671143.DAMO_0072 1.632e-242 755.0 COG1220@1|root,COG1220@2|Bacteria,2NP00@2323|unclassified Bacteria 2|Bacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small GNS1_k127_3473062_7 671143.DAMO_0073 4.79e-141 452.0 COG0548@1|root,COG0548@2|Bacteria,2NQHT@2323|unclassified Bacteria 2|Bacteria E Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 AA_kinase GNS1_k127_3473062_4 671143.DAMO_0074 4.668e-207 652.0 COG4992@1|root,COG4992@2|Bacteria,2NP1Z@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class-III argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iAF987.Gmet_0204,iHN637.CLJU_RS10560 Aminotran_3 GNS1_k127_3473062_5 671143.DAMO_0075 3.681e-158 503.0 COG0078@1|root,COG0078@2|Bacteria,2NNWN@2323|unclassified Bacteria 2|Bacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N GNS1_k127_3473062_2 671143.DAMO_0085 9.472e-233 726.0 COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria 2|Bacteria E Arginosuccinate synthase argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.argG,iSB619.SA_RS04675 Arginosuc_synth GNS1_k127_3473062_8 671143.DAMO_0086 2.617e-84 284.0 COG0165@1|root,COG0165@2|Bacteria,2NP70@2323|unclassified Bacteria 2|Bacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K01755,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844,M00845 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 GNS1_k127_3515485_0 1120985.AUMI01000014_gene1141 2.487e-288 914.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,4H21Q@909932|Negativicutes 909932|Negativicutes J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 GNS1_k127_3515485_4 671143.DAMO_0663 3.2e-108 356.0 COG0340@1|root,COG0340@2|Bacteria,2NPG2@2323|unclassified Bacteria 2|Bacteria H biotin acetyl-CoA-carboxylase ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB GNS1_k127_3515485_3 671143.DAMO_0664 3.236e-134 430.0 COG1521@1|root,COG1521@2|Bacteria,2NP3Z@2323|unclassified Bacteria 2|Bacteria K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1986 Pan_kinase GNS1_k127_3515485_7 671143.DAMO_0665 3.85e-36 138.0 COG1826@1|root,COG1826@2|Bacteria 2|Bacteria U protein secretion pcmP - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 GNS1_k127_3515485_5 671143.DAMO_0666 2.48e-76 258.0 COG0102@1|root,COG0102@2|Bacteria,2NPCI@2323|unclassified Bacteria 2|Bacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 GNS1_k127_3515485_6 671143.DAMO_0667 5.059e-62 215.0 COG0103@1|root,COG0103@2|Bacteria,2NPN8@2323|unclassified Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 GNS1_k127_3515485_1 671143.DAMO_0668 1.199e-174 553.0 COG0002@1|root,COG0002@2|Bacteria,2NNN5@2323|unclassified Bacteria 2|Bacteria E Belongs to the NAGSA dehydrogenase family. Type 1 subfamily argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145,ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R03443,R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190 Semialdhyde_dh,Semialdhyde_dhC GNS1_k127_3515485_2 671143.DAMO_0669 3.174e-173 552.0 COG1364@1|root,COG1364@2|Bacteria,2NQKS@2323|unclassified Bacteria 2|Bacteria E ArgJ family argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1783 ArgJ GNS1_k127_3529447_1 671143.DAMO_2605 5.028e-172 548.0 COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria 2|Bacteria S MMPL family hpnN - - ko:K07003 - - - - ko00000 - - - MMPL GNS1_k127_3529447_3 671143.DAMO_2606 8.414e-74 254.0 COG2854@1|root,COG2854@2|Bacteria 2|Bacteria Q intermembrane phospholipid transfer - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC GNS1_k127_3529447_4 1265505.ATUG01000002_gene2574 8.529e-05 48.0 2EINH@1|root,33CDW@2|Bacteria,1NN5W@1224|Proteobacteria,42XC5@68525|delta/epsilon subdivisions,2WT26@28221|Deltaproteobacteria,2MMA6@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - GNS1_k127_3529447_2 886293.Sinac_0562 6.525e-162 522.0 COG3391@1|root,COG3391@2|Bacteria,2J3CG@203682|Planctomycetes 203682|Planctomycetes S 56kDa selenium binding protein (SBP56) - - - ko:K17285 - - - - ko00000,ko04147 - - - SBP56 GNS1_k127_3529447_0 671143.DAMO_2615 6.92e-257 797.0 COG0312@1|root,COG0312@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD GNS1_k127_3583592_0 671143.DAMO_2103 1.61e-230 716.0 COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria 2|Bacteria J Ribonuclease E/G family rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 GNS1_k127_3583592_11 671143.DAMO_0327 2.075e-47 172.0 COG0261@1|root,COG0261@2|Bacteria,2NPSX@2323|unclassified Bacteria 2|Bacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p GNS1_k127_3583592_13 671143.DAMO_0328 6.647e-42 154.0 COG0211@1|root,COG0211@2|Bacteria,2NPSU@2323|unclassified Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 GNS1_k127_3583592_4 671143.DAMO_0330 3.658e-168 534.0 COG0536@1|root,COG0536@2|Bacteria,2NNS6@2323|unclassified Bacteria 2|Bacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 GNS1_k127_3583592_3 671143.DAMO_0331 3.486e-179 568.0 COG0263@1|root,COG0263@2|Bacteria,2NQMJ@2323|unclassified Bacteria 2|Bacteria E PUA domain proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3198 AA_kinase,PUA GNS1_k127_3583592_1 671143.DAMO_0332 7.307e-220 687.0 COG0014@1|root,COG0014@2|Bacteria,2NQM3@2323|unclassified Bacteria 2|Bacteria E Aldehyde dehydrogenase family proA GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0293,iYO844.BSU13130 Aldedh GNS1_k127_3583592_7 671143.DAMO_0333 2.531e-105 346.0 COG1057@1|root,COG1057@2|Bacteria,2NPJU@2323|unclassified Bacteria 2|Bacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - CTP_transf_like GNS1_k127_3583592_10 671143.DAMO_0334 2.792e-54 193.0 COG0799@1|root,COG0799@2|Bacteria,2NPYI@2323|unclassified Bacteria 2|Bacteria S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RsfS GNS1_k127_3583592_12 671143.DAMO_0335 2.515e-47 174.0 COG1734@1|root,COG1734@2|Bacteria,2NQ6S@2323|unclassified Bacteria 2|Bacteria T Prokaryotic dksA/traR C4-type zinc finger dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR GNS1_k127_3583592_9 671143.DAMO_0337 1.377e-65 233.0 COG1040@1|root,COG1040@2|Bacteria,2NPMC@2323|unclassified Bacteria 2|Bacteria S competence protein comF GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 3.6.4.12 ko:K02242,ko:K03654 ko03018,map03018 M00429 - - ko00000,ko00001,ko00002,ko01000,ko02044,ko03400 - - - Pribosyltran GNS1_k127_3583592_6 1173028.ANKO01000038_gene4764 3.367e-142 462.0 COG3227@1|root,COG3227@2|Bacteria,1G3KW@1117|Cyanobacteria,1H7JS@1150|Oscillatoriales 1117|Cyanobacteria E Thermolysin metallopeptidase, alpha-helical domain - - - - - - - - - - - - FTP,Peptidase_M4,Peptidase_M4_C GNS1_k127_3583592_14 1173028.ANKO01000038_gene4765 4.982e-20 93.0 2E4G4@1|root,32ZB9@2|Bacteria,1G9UK@1117|Cyanobacteria,1HD1D@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - GNS1_k127_3583592_2 671143.DAMO_0339 2.197e-192 604.0 COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria 2|Bacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N GNS1_k127_3583592_5 1304880.JAGB01000002_gene2025 1.741e-146 474.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK GNS1_k127_3583592_8 671143.DAMO_0342 3.424e-104 342.0 COG0149@1|root,COG0149@2|Bacteria,2NP24@2323|unclassified Bacteria 2|Bacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_4715 TIM GNS1_k127_361685_0 671143.DAMO_2457 1.608e-233 726.0 COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria 2|Bacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 GNS1_k127_361685_1 671143.DAMO_2455 1.494e-200 632.0 COG0513@1|root,COG0513@2|Bacteria,2NP0A@2323|unclassified Bacteria 2|Bacteria JKL Belongs to the DEAD box helicase family rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732,ko:K05592,ko:K11927 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C GNS1_k127_361685_2 671143.DAMO_2416 2.111e-172 547.0 COG0182@1|root,COG0182@2|Bacteria,2NNM7@2323|unclassified Bacteria 2|Bacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0072 IF-2B GNS1_k127_362240_2 671143.DAMO_2057 2.7e-98 327.0 COG0820@1|root,COG0820@2|Bacteria,2NP4V@2323|unclassified Bacteria 2|Bacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM GNS1_k127_362240_1 671143.DAMO_2058 1.147e-104 346.0 COG0457@1|root,COG0457@2|Bacteria,2NQ11@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2,TPR_8 GNS1_k127_362240_0 671143.DAMO_2059 8.326e-139 448.0 COG1559@1|root,COG1559@2|Bacteria,2NP75@2323|unclassified Bacteria 2|Bacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG GNS1_k127_3659747_5 1122165.AUHS01000019_gene1578 3.184e-44 174.0 2BVG0@1|root,32QV2@2|Bacteria,1QN3M@1224|Proteobacteria,1TKHB@1236|Gammaproteobacteria,1JDZA@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - GNS1_k127_3659747_8 449447.MAE_07940 3.498e-24 106.0 COG2026@1|root,COG2026@2|Bacteria,1G99H@1117|Cyanobacteria 1117|Cyanobacteria DJ ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin GNS1_k127_3659747_9 744872.Spica_2160 1.733e-14 78.0 COG2161@1|root,COG2161@2|Bacteria,2J8GQ@203691|Spirochaetes 203691|Spirochaetes D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox GNS1_k127_3659747_7 794903.OPIT5_20675 4.839e-26 113.0 COG0449@1|root,COG0449@2|Bacteria 2|Bacteria M glutamine-fructose-6-phosphate transaminase (isomerizing) activity - - - - - - - - - - - - ORF6N,SIS GNS1_k127_3659747_11 1121413.JMKT01000003_gene170 0.0006651 43.0 COG0449@1|root,COG0449@2|Bacteria,1RGWX@1224|Proteobacteria,42TA9@68525|delta/epsilon subdivisions,2WPHJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M ORF6N domain - - - - - - - - - - - - ORF6N GNS1_k127_3659747_10 1459636.NTE_00225 3.332e-14 78.0 COG4113@1|root,arCOG00727@2157|Archaea 2157|Archaea S PilT protein domain protein - - - - - - - - - - - - PIN GNS1_k127_3659747_0 671143.DAMO_2750 1.542e-307 952.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2NNNK@2323|unclassified Bacteria 2|Bacteria L DNA polymerase X family polX - - ko:K02347,ko:K04477 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP GNS1_k127_3659747_4 1303518.CCALI_01870 5.138e-49 189.0 COG1341@1|root,COG1341@2|Bacteria 2|Bacteria S polynucleotide 5'-hydroxyl-kinase activity - - - ko:K06947 - - - - ko00000,ko01000,ko03009 - - - CLP1_P GNS1_k127_3659747_2 443143.GM18_3369 2.425e-167 537.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,43TKB@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_3659747_1 243231.GSU0812 1.567e-172 567.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,43TNJ@69541|Desulfuromonadales 28221|Deltaproteobacteria T histidine kinase, HAMP ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 GNS1_k127_3659747_3 671143.DAMO_2751 1.286e-156 499.0 COG0774@1|root,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria 2|Bacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108,4.2.1.59 ko:K02535,ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - iECS88_1305.ECS88_0100 LpxC GNS1_k127_3659747_6 671143.DAMO_2752 6.098e-31 124.0 COG5512@1|root,COG5512@2|Bacteria 2|Bacteria L Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - - - - - - - - - - DUF721 GNS1_k127_3686518_12 1128421.JAGA01000003_gene2922 3.675e-66 228.0 COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria 2|Bacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 GNS1_k127_3686518_2 671143.DAMO_1443 3.129e-181 573.0 COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria 2|Bacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA GNS1_k127_3686518_5 671143.DAMO_1442 4.775e-147 469.0 COG0074@1|root,COG0074@2|Bacteria,2NNZD@2323|unclassified Bacteria 2|Bacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0001539,GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0016874,GO:0016877,GO:0016878,GO:0019538,GO:0031974,GO:0032991,GO:0036211,GO:0040011,GO:0042709,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0046777,GO:0048870,GO:0051179,GO:0051674,GO:0070013,GO:0071704,GO:0071973,GO:0097588,GO:1901564,GO:1902494 6.2.1.5 ko:K01902,ko:K02381 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_0608,iYO844.BSU16100 CoA_binding,DUF1116,Ligase_CoA GNS1_k127_3686518_13 671143.DAMO_1441 2.059e-64 224.0 COG0105@1|root,COG0105@2|Bacteria,2NPM5@2323|unclassified Bacteria 2|Bacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK GNS1_k127_3686518_11 671143.DAMO_1440 2.036e-71 244.0 COG1399@1|root,COG1399@2|Bacteria,2NQ7G@2323|unclassified Bacteria 2|Bacteria S Uncharacterized ACR, COG1399 yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 GNS1_k127_3686518_16 1382359.JIAL01000001_gene525 3.09e-22 100.0 COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JJZ9@204432|Acidobacteriia 204432|Acidobacteriia J Ribosomal L32p protein family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p GNS1_k127_3686518_4 671143.DAMO_1438 6.463e-166 526.0 COG0416@1|root,COG0416@2|Bacteria,2NP1H@2323|unclassified Bacteria 2|Bacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.21.4.2,1.21.4.3,1.21.4.4,2.3.1.15 ko:K03621,ko:K21576,ko:K21577 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis GNS1_k127_3686518_3 671143.DAMO_1437 6.21e-167 529.0 COG0332@1|root,COG0332@2|Bacteria,2NNX5@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C GNS1_k127_3686518_6 671143.DAMO_1436 5.478e-128 416.0 COG0331@1|root,COG0331@2|Bacteria,2NP3V@2323|unclassified Bacteria 2|Bacteria I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 GNS1_k127_3686518_7 671143.DAMO_1435 2.145e-97 324.0 COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GNS1_k127_3686518_15 671143.DAMO_1434 1.668e-32 128.0 COG0236@1|root,COG0236@2|Bacteria,2NPVJ@2323|unclassified Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding GNS1_k127_3686518_1 671143.DAMO_1433 1.037e-218 683.0 COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179,2.3.1.41 ko:K00647,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Ketoacyl-synt_C,ketoacyl-synt GNS1_k127_3686518_14 671143.DAMO_1430 1.588e-57 203.0 COG0781@1|root,COG0781@2|Bacteria,2NPZI@2323|unclassified Bacteria 2|Bacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB GNS1_k127_3686518_10 671143.DAMO_1429 7.02e-75 255.0 COG0054@1|root,COG0054@2|Bacteria,2NP8G@2323|unclassified Bacteria 2|Bacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1825,iSB619.SA_RS08940,iSFV_1184.SFV_0380 DMRL_synthase GNS1_k127_3686518_0 671143.DAMO_1428 1.508e-231 720.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2NNKV@2323|unclassified Bacteria 2|Bacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25,4.1.99.12 ko:K01497,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10830,iSB619.SA_RS08945 DHBP_synthase,GTP_cyclohydro2 GNS1_k127_3686518_8 671143.DAMO_1427 2.27e-89 299.0 COG0307@1|root,COG0307@2|Bacteria,2NPD0@2323|unclassified Bacteria 2|Bacteria H Lumazine binding domain ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU23270 Lum_binding GNS1_k127_3686518_9 671143.DAMO_1426 3.643e-80 270.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2NNZJ@2323|unclassified Bacteria 2|Bacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1624,iLJ478.TM1828 RibD_C,dCMP_cyt_deam_1 GNS1_k127_3724880_12 589865.DaAHT2_1496 1.143e-07 63.0 COG5662@1|root,COG5662@2|Bacteria 2|Bacteria K AntiSigma factor - - - - - - - - - - - - DUF4349,zf-HC2 GNS1_k127_3724880_2 292459.STH845 6.926e-43 166.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia 186801|Clostridia K TIGRFAM RNA polymerase sigma factor, sigma-70 family algU - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GNS1_k127_3724880_10 933262.AXAM01000011_gene1792 2.118e-09 62.0 COG4118@1|root,COG4118@2|Bacteria 2|Bacteria D positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - - - - - - - - - - PhdYeFM_antitox GNS1_k127_3724880_6 1123386.AUIW01000009_gene1812 3.493e-28 118.0 COG1848@1|root,COG1848@2|Bacteria,1WKJ4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Toxic component of a toxin-antitoxin (TA) module. An RNase - - - - - - - - - - - - - GNS1_k127_3724880_1 309801.trd_A0852 2.911e-61 215.0 COG0717@1|root,COG0717@2|Bacteria,2GBA2@200795|Chloroflexi,27Y8U@189775|Thermomicrobia 189775|Thermomicrobia F dUTPase - - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase GNS1_k127_3724880_3 671143.DAMO_0140 4.862e-34 134.0 COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria 2|Bacteria K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD GNS1_k127_3724880_5 1033743.CAES01000061_gene4490 4.989e-29 127.0 COG0457@1|root,COG0457@2|Bacteria,1V3MA@1239|Firmicutes,4HH74@91061|Bacilli,26SMD@186822|Paenibacillaceae 91061|Bacilli S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 GNS1_k127_3724880_0 880072.Desac_1601 6.969e-145 486.0 COG0421@1|root,COG0421@2|Bacteria 2|Bacteria E spermidine synthase activity - - - - - - - - - - - - Spermine_synth GNS1_k127_3724880_4 91604.ID47_01230 1.047e-31 126.0 COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,2UGH7@28211|Alphaproteobacteria,47GBY@766|Rickettsiales 766|Rickettsiales S Cytotoxic translational repressor of toxin-antitoxin stability system - - - - - - - - - - - - - GNS1_k127_3724880_7 384676.PSEEN1833 1.059e-24 106.0 COG2944@1|root,COG2944@2|Bacteria,1N5H0@1224|Proteobacteria,1SEZI@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3,HTH_31 GNS1_k127_3724880_8 880072.Desac_0423 1.33e-23 102.0 COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,42VMA@68525|delta/epsilon subdivisions,2WS3K@28221|Deltaproteobacteria,2MS7F@213462|Syntrophobacterales 28221|Deltaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin GNS1_k127_3724880_9 497965.Cyan7822_3224 4.231e-16 81.0 2C6B2@1|root,335GA@2|Bacteria,1GRBH@1117|Cyanobacteria,3KKV9@43988|Cyanothece 1117|Cyanobacteria - - - - - - - - - - - - - - - GNS1_k127_3724880_11 631362.Thi970DRAFT_00649 6.951e-09 56.0 COG1598@1|root,COG1598@2|Bacteria 2|Bacteria N PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - HicB_lk_antitox GNS1_k127_3793379_3 671143.DAMO_0057 1.837e-72 246.0 COG0279@1|root,COG0279@2|Bacteria,2NPPB@2323|unclassified Bacteria 2|Bacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HupF_HypC,SIS_2 GNS1_k127_3793379_2 671143.DAMO_0058 3.662e-121 397.0 COG1686@1|root,COG1686@2|Bacteria,2NPJT@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S11 family dacA - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11 GNS1_k127_3793379_1 671143.DAMO_0059 5.793e-177 565.0 COG0272@1|root,COG0758@1|root,COG0272@2|Bacteria,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria 2|Bacteria LU DNA recombination-mediator protein A ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 ko:K01972,ko:K02342,ko:K04096 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440 M00260 R00375,R00376,R00377,R00378,R00382 RC00005,RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,DNA_processg_A,HHH_2,HHH_5 GNS1_k127_3793379_0 671143.DAMO_0060 1.24e-265 825.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2NNS8@2323|unclassified Bacteria 2|Bacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168,ko:K07479 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom GNS1_k127_3818691_13 584708.Apau_1119 5.563e-115 376.0 COG4336@1|root,COG4336@2|Bacteria,3T9Q8@508458|Synergistetes 508458|Synergistetes S Belongs to the D-glutamate cyclase family - - - - - - - - - - - - DUF1445 GNS1_k127_3818691_20 395963.Bind_0186 2.853e-11 67.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria,3NC90@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B GNS1_k127_3818691_5 1288494.EBAPG3_31440 4.635e-172 557.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria,371XI@32003|Nitrosomonadales 28216|Betaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - GNS1_k127_3818691_2 671143.DAMO_2187 2.676e-218 683.0 COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N,Response_reg GNS1_k127_3818691_1 671143.DAMO_2186 3.081e-220 691.0 COG0148@1|root,COG0148@2|Bacteria,2NNKW@2323|unclassified Bacteria 2|Bacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N GNS1_k127_3818691_9 404589.Anae109_4383 1.09e-144 473.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2YUEU@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C GNS1_k127_3818691_7 671143.DAMO_2184 4.855e-154 492.0 COG0611@1|root,COG0611@2|Bacteria,2NP8J@2323|unclassified Bacteria 2|Bacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946,ko:K07123 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2977c,iSFV_1184.SFV_0382,iYO844.BSU05900 AIRS,AIRS_C GNS1_k127_3818691_10 671143.DAMO_2183 7.156e-127 413.0 COG0030@1|root,COG0030@2|Bacteria,2NPDT@2323|unclassified Bacteria 2|Bacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD GNS1_k127_3818691_12 671143.DAMO_2182 7.042e-121 395.0 COG4105@1|root,COG4105@2|Bacteria,2NPZ3@2323|unclassified Bacteria 2|Bacteria S Outer membrane lipoprotein bamD - - ko:K05807,ko:K08309 - - - - ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 - YfiO GNS1_k127_3818691_0 671143.DAMO_2181 9.234e-254 784.0 COG1219@1|root,COG1219@2|Bacteria,2NNN2@2323|unclassified Bacteria 2|Bacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX GNS1_k127_3818691_15 671143.DAMO_2179 6.097e-106 354.0 COG0740@1|root,COG0740@2|Bacteria,2NNPA@2323|unclassified Bacteria 2|Bacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease GNS1_k127_3818691_4 671143.DAMO_2178 3.918e-180 572.0 COG0544@1|root,COG0544@2|Bacteria,2NPBN@2323|unclassified Bacteria 2|Bacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N GNS1_k127_3818691_3 671143.DAMO_2177 7.07e-182 576.0 COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria 2|Bacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N GNS1_k127_3818691_14 671143.DAMO_2164 2.569e-107 352.0 COG0120@1|root,COG0120@2|Bacteria,2NPMQ@2323|unclassified Bacteria 2|Bacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 ko:K00851,ko:K00852,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01051,R01056,R01737,R02750 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A GNS1_k127_3818691_6 671143.DAMO_2163 3.082e-169 536.0 COG0158@1|root,COG0158@2|Bacteria,2NQQI@2323|unclassified Bacteria 2|Bacteria G Belongs to the FBPase class 1 family fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - iUTI89_1310.UTI89_C4836,ic_1306.c5329 FBPase GNS1_k127_3818691_8 330214.NIDE2980 9.525e-148 473.0 COG1830@1|root,COG1830@2|Bacteria,3J1DE@40117|Nitrospirae 40117|Nitrospirae G DeoC/LacD family aldolase - - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC GNS1_k127_3818691_17 671143.DAMO_1046 3.604e-63 219.0 COG4747@1|root,COG4747@2|Bacteria,2NR4R@2323|unclassified Bacteria 2|Bacteria S ACT domain protein hom - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00570 R00220,R00996,R01513,R01773,R01775 RC00031,RC00087,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 GNS1_k127_3818691_11 671143.DAMO_1047 5.347e-121 393.0 COG1540@1|root,COG1540@2|Bacteria,2NQVM@2323|unclassified Bacteria 2|Bacteria S LamB/YcsF family ycsF - - ko:K07160 - - - - ko00000 - - - LamB_YcsF GNS1_k127_3818691_16 671143.DAMO_1048 1.802e-89 300.0 COG2049@1|root,COG2049@2|Bacteria,2NR1P@2323|unclassified Bacteria 2|Bacteria E Allophanate hydrolase subunit 1 ybgJ - 3.5.1.54 ko:K01457,ko:K06351,ko:K07160 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - CT_C_D GNS1_k127_3818691_19 671143.DAMO_1049 3.904e-29 123.0 COG1984@1|root,COG1984@2|Bacteria,2NQWF@2323|unclassified Bacteria 2|Bacteria E Allophanate hydrolase subunit 2 kipA - - ko:K06350 - - - - ko00000 - - - CT_A_B,CT_C_D GNS1_k127_3830468_2 886293.Sinac_1574 8.401e-21 96.0 COG2146@1|root,COG2146@2|Bacteria,2J0ZZ@203682|Planctomycetes 203682|Planctomycetes P COG2146 Ferredoxin subunits of nitrite reductase and - - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske GNS1_k127_3830468_0 671143.DAMO_0695 4.581e-213 667.0 COG0205@1|root,COG0205@2|Bacteria,2NNXU@2323|unclassified Bacteria 2|Bacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 ko:K00850,ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK GNS1_k127_3841687_1 671143.DAMO_1329 0.0 1220.0 COG0013@1|root,COG0013@2|Bacteria,2NNYC@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD GNS1_k127_3841687_10 671143.DAMO_1339 6.776e-91 303.0 COG0688@1|root,COG0688@2|Bacteria,2NPRX@2323|unclassified Bacteria 2|Bacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase GNS1_k127_3841687_7 671143.DAMO_1340 1.778e-124 404.0 COG1183@1|root,COG1183@2|Bacteria,2NPQM@2323|unclassified Bacteria 2|Bacteria I CDP-alcohol phosphatidyltransferase pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf GNS1_k127_3841687_2 671143.DAMO_1341 6.691e-300 925.0 COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS10690,iYO844.BSU28280 HMGL-like,LeuA_dimer GNS1_k127_3841687_3 671143.DAMO_1342 4.665e-175 554.0 COG0136@1|root,COG0136@2|Bacteria,2NNX3@2323|unclassified Bacteria 2|Bacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1523 Semialdhyde_dh,Semialdhyde_dhC GNS1_k127_3841687_8 671143.DAMO_1343 2.193e-111 365.0 COG0101@1|root,COG0101@2|Bacteria,2NPEC@2323|unclassified Bacteria 2|Bacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 GNS1_k127_3841687_5 671143.DAMO_1345 2.289e-131 428.0 COG1651@1|root,COG1651@2|Bacteria,2NPXE@2323|unclassified Bacteria 2|Bacteria O Thioredoxin - - - - - - - - - - - - SurA_N_3,Thioredoxin_4 GNS1_k127_3841687_0 671143.DAMO_1355 0.0 1469.0 COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 GNS1_k127_3841687_11 671143.DAMO_1356 1.048e-65 229.0 COG2980@1|root,COG2980@2|Bacteria,2NQ1I@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences lptE GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788 LptE GNS1_k127_3841687_6 671143.DAMO_1357 1.685e-129 421.0 COG1466@1|root,COG1466@2|Bacteria,2NPN5@2323|unclassified Bacteria 2|Bacteria L DNA polymerase III delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta,DNA_pol3_gamma3 GNS1_k127_3841687_12 671143.DAMO_1358 6.92e-27 114.0 COG0268@1|root,COG0268@2|Bacteria,2NQ42@2323|unclassified Bacteria 2|Bacteria J Binds directly to 16S ribosomal RNA rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p GNS1_k127_3841687_4 671143.DAMO_1360 8.008e-167 541.0 COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria 2|Bacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN GNS1_k127_3841687_9 56107.Cylst_0495 1.056e-110 365.0 COG0028@1|root,COG0028@2|Bacteria 2|Bacteria EH Belongs to the TPP enzyme family - GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016744,GO:0016999,GO:0017000,GO:0017144,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0048037,GO:0050662,GO:0097159,GO:1901363,GO:1901681 1.2.3.3,2.2.1.12,2.2.1.6 ko:K00158,ko:K01652,ko:K21428 ko00290,ko00333,ko00620,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00333,map00620,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570,M00837 R00006,R00014,R00207,R00226,R03050,R04672,R04673,R08648,R11141 RC00027,RC00106,RC01192,RC02744,RC02745,RC02893,RC03367 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N GNS1_k127_3897418_0 1297742.A176_02674 4.175e-45 170.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,2YV6M@29|Myxococcales 28221|Deltaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284,ko:K16074 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3,1.A.35.4 - - CorA GNS1_k127_3897418_1 1441629.PCH70_00990 2.872e-38 156.0 28IX1@1|root,2Z8V3@2|Bacteria,1N0WD@1224|Proteobacteria,1RSH6@1236|Gammaproteobacteria,1Z7CE@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 GNS1_k127_3897418_2 671143.DAMO_3038 3.886e-22 96.0 COG0586@1|root,COG0586@2|Bacteria,2NQ0I@2323|unclassified Bacteria 2|Bacteria S SNARE associated Golgi protein dedA - 3.6.1.27 ko:K03975,ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc GNS1_k127_3916269_2 671143.DAMO_2476 2.105e-49 179.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity - - 2.6.1.9,3.1.3.10,3.8.1.2 ko:K00817,ko:K01560,ko:K07025,ko:K20866 ko00010,ko00340,ko00350,ko00360,ko00361,ko00400,ko00401,ko00625,ko00960,ko01100,ko01110,ko01120,ko01130,ko01230,map00010,map00340,map00350,map00360,map00361,map00400,map00401,map00625,map00960,map01100,map01110,map01120,map01130,map01230 M00026 R00694,R00734,R00947,R03243,R05287 RC00006,RC00078,RC00697,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - HAD_2,Hydrolase GNS1_k127_3916269_1 671143.DAMO_2474 2.32e-78 265.0 COG1793@1|root,COG1793@2|Bacteria,2NR3Z@2323|unclassified Bacteria 2|Bacteria L DNA polymerase Ligase (LigD) ligD - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N GNS1_k127_3916269_0 671143.DAMO_2471 5.763e-247 768.0 COG1027@1|root,COG1027@2|Bacteria,2NNUK@2323|unclassified Bacteria 2|Bacteria E Fumarase C C-terminus aspA - 4.2.1.2,4.3.1.1 ko:K01679,ko:K01744 ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R00490,R01082 RC00316,RC00443,RC02799 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 GNS1_k127_3916269_3 671143.DAMO_1386 3.737e-41 155.0 COG0634@1|root,COG0634@2|Bacteria,2NPER@2323|unclassified Bacteria 2|Bacteria F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,2.7.4.3,6.3.4.19 ko:K00760,ko:K00939,ko:K15780 ko00230,ko00730,ko00983,ko01100,ko01110,ko01130,map00230,map00730,map00983,map01100,map01110,map01130 M00049 R00127,R00190,R01132,R01229,R01547,R02142,R08237,R08238,R08245,R11319 RC00002,RC00063,RC00122 ko00000,ko00001,ko00002,ko01000,ko03016,ko04147 - - iHN637.CLJU_RS16720 ADK,Pribosyltran GNS1_k127_3919628_3 682795.AciX8_2537 1.124e-22 113.0 COG1807@1|root,COG1807@2|Bacteria,3Y2T0@57723|Acidobacteria,2JIGT@204432|Acidobacteriia 204432|Acidobacteriia M PFAM glycosyl transferase family 39 - - - - - - - - - - - - PMT_2 GNS1_k127_3919628_1 190650.CC_2891 1.541e-40 160.0 COG2227@1|root,COG2227@2|Bacteria,1QTWG@1224|Proteobacteria,2TX57@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 GNS1_k127_3919628_0 351160.RCIX209 1.204e-42 167.0 COG0500@1|root,arCOG01789@2157|Archaea,2Y3U4@28890|Euryarchaeota,2NAUS@224756|Methanomicrobia 224756|Methanomicrobia Q Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_11 GNS1_k127_3919628_2 479434.Sthe_0859 1.038e-38 149.0 COG0463@1|root,COG0463@2|Bacteria,2G5X5@200795|Chloroflexi,27XQE@189775|Thermomicrobia 189775|Thermomicrobia M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_392597_2 671143.DAMO_3130 6.87e-36 140.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity yacD - 5.2.1.8 ko:K03770,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 GNS1_k127_392597_0 671143.DAMO_3131 8.327e-198 619.0 COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria 2|Bacteria D MreB/Mbl protein mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl GNS1_k127_392597_1 671143.DAMO_3132 6.249e-107 352.0 COG1792@1|root,COG1792@2|Bacteria,2NPNX@2323|unclassified Bacteria 2|Bacteria M Cell shape-determining protein MreC mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC GNS1_k127_3929503_1 671143.DAMO_2990 1.503e-76 259.0 COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria 2|Bacteria S 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD GNS1_k127_3929503_3 1265505.ATUG01000001_gene3648 2.22e-23 105.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,42W3M@68525|delta/epsilon subdivisions,2WP9C@28221|Deltaproteobacteria,2MK7D@213118|Desulfobacterales 28221|Deltaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 GNS1_k127_3929503_2 1121406.JAEX01000006_gene2191 1.253e-41 166.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 GNS1_k127_3929503_0 671143.DAMO_2993 3.215e-108 353.0 COG1159@1|root,COG1159@2|Bacteria,2NP0U@2323|unclassified Bacteria 2|Bacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - ko:K03595,ko:K06883 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 GNS1_k127_3953881_28 671143.DAMO_0569 2.796e-35 138.0 COG0779@1|root,COG0779@2|Bacteria,2NPVA@2323|unclassified Bacteria 2|Bacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C GNS1_k127_3953881_0 671143.DAMO_0568 0.0 1107.0 COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria 2|Bacteria J elongation factor G fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 GNS1_k127_3953881_16 671143.DAMO_0567 2.716e-66 229.0 COG0203@1|root,COG0203@2|Bacteria,2NPYQ@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein L17 rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02879,ko:K16193 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 GNS1_k127_3953881_2 671143.DAMO_0566 8.68e-180 567.0 COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L GNS1_k127_3953881_7 671143.DAMO_0565 7.076e-98 323.0 COG0522@1|root,COG0522@2|Bacteria,2NPCC@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 GNS1_k127_3953881_15 671143.DAMO_0564 1.04e-66 229.0 COG0100@1|root,COG0100@2|Bacteria,2NPCN@2323|unclassified Bacteria 2|Bacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 GNS1_k127_3953881_21 1121472.AQWN01000002_gene2063 2.1e-51 184.0 COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,261QX@186807|Peptococcaceae 186801|Clostridia J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 GNS1_k127_3953881_32 1280668.ATVT01000003_gene2508 5.612e-15 76.0 COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia,4C0FI@830|Butyrivibrio 186801|Clostridia J Ribosomal protein L36 rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 GNS1_k127_3953881_26 671143.DAMO_0562 3.546e-38 149.0 COG0361@1|root,COG0361@2|Bacteria,2NPNU@2323|unclassified Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a GNS1_k127_3953881_5 671143.DAMO_0561 8.192e-118 383.0 COG0024@1|root,COG0024@2|Bacteria,2NP57@2323|unclassified Bacteria 2|Bacteria J Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 GNS1_k127_3953881_9 671143.DAMO_0560 8.692e-95 314.0 COG0563@1|root,COG0563@2|Bacteria,2NPBU@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid GNS1_k127_3953881_1 671143.DAMO_0559 1.779e-237 739.0 COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria 2|Bacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY GNS1_k127_3953881_14 671143.DAMO_0558 1.529e-71 247.0 COG0200@1|root,COG0200@2|Bacteria,2NPNV@2323|unclassified Bacteria 2|Bacteria J Binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A GNS1_k127_3953881_30 671143.DAMO_0557 1.453e-21 95.0 COG1841@1|root,COG1841@2|Bacteria,2NQ1P@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein L30 rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 GNS1_k127_3953881_12 671143.DAMO_0556 6.389e-75 256.0 COG0098@1|root,COG0098@2|Bacteria,2NPGN@2323|unclassified Bacteria 2|Bacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C GNS1_k127_3953881_24 671143.DAMO_0555 2.182e-44 164.0 COG0256@1|root,COG0256@2|Bacteria,2NPVI@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p GNS1_k127_3953881_10 671143.DAMO_0554 5.518e-90 299.0 COG0097@1|root,COG0097@2|Bacteria,2NPAS@2323|unclassified Bacteria 2|Bacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 GNS1_k127_3953881_18 671143.DAMO_0553 2.648e-60 212.0 COG0096@1|root,COG0096@2|Bacteria,2NPMS@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 GNS1_k127_3953881_29 671143.DAMO_0552 1.594e-28 116.0 COG0199@1|root,COG0199@2|Bacteria,2NPW7@2323|unclassified Bacteria 2|Bacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 GNS1_k127_3953881_6 671143.DAMO_0551 1.515e-103 342.0 COG0094@1|root,COG0094@2|Bacteria,2NP65@2323|unclassified Bacteria 2|Bacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C GNS1_k127_3953881_22 671143.DAMO_0550 4.336e-51 183.0 COG0198@1|root,COG0198@2|Bacteria,2NPT6@2323|unclassified Bacteria 2|Bacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 GNS1_k127_3953881_17 671143.DAMO_0549 3.146e-62 215.0 COG0093@1|root,COG0093@2|Bacteria,2NPCS@2323|unclassified Bacteria 2|Bacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 GNS1_k127_3953881_27 671143.DAMO_0548 1.304e-35 139.0 COG0186@1|root,COG0186@2|Bacteria,2NPVE@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 GNS1_k127_3953881_31 671143.DAMO_0547 1.631e-18 87.0 COG0255@1|root,COG0255@2|Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 GNS1_k127_3953881_13 671143.DAMO_0546 1.299e-72 248.0 COG0197@1|root,COG0197@2|Bacteria,2NPC6@2323|unclassified Bacteria 2|Bacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 GNS1_k127_3953881_4 671143.DAMO_0545 1.13e-124 403.0 COG0092@1|root,COG0092@2|Bacteria,2NP6J@2323|unclassified Bacteria 2|Bacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C GNS1_k127_3953881_20 671143.DAMO_0544 4.231e-55 196.0 COG0091@1|root,COG0091@2|Bacteria,2NPNW@2323|unclassified Bacteria 2|Bacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 GNS1_k127_3953881_23 671143.DAMO_0543 6.666e-48 173.0 COG0185@1|root,COG0185@2|Bacteria,2NPIV@2323|unclassified Bacteria 2|Bacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 GNS1_k127_3953881_3 671143.DAMO_0542 1.468e-147 470.0 COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C GNS1_k127_3953881_25 671143.DAMO_0541 1.501e-39 149.0 COG0089@1|root,COG0089@2|Bacteria,2NPWC@2323|unclassified Bacteria 2|Bacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 GNS1_k127_3953881_11 671143.DAMO_0540 6.815e-85 286.0 COG0088@1|root,COG0088@2|Bacteria,2NPF3@2323|unclassified Bacteria 2|Bacteria J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 GNS1_k127_3953881_8 671143.DAMO_0539 7.665e-96 318.0 COG0087@1|root,COG0087@2|Bacteria,2NPAI@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 GNS1_k127_3953881_19 671143.DAMO_0538 3.936e-57 200.0 COG0051@1|root,COG0051@2|Bacteria,2NPJY@2323|unclassified Bacteria 2|Bacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 GNS1_k127_3997207_3 1197906.CAJQ02000004_gene3120 4.516e-143 463.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2TT62@28211|Alphaproteobacteria,3JSQG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase GNS1_k127_3997207_16 1297742.A176_00069 1.467e-10 68.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,430H4@68525|delta/epsilon subdivisions,2WVV3@28221|Deltaproteobacteria,2YX5H@29|Myxococcales 28221|Deltaproteobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase phoK - - - - - - - - - - - Phosphodiest GNS1_k127_3997207_10 391735.Veis_2543 2.785e-46 176.0 COG1028@1|root,COG1028@2|Bacteria,1PE9X@1224|Proteobacteria,2W1MZ@28216|Betaproteobacteria 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 GNS1_k127_3997207_14 1133849.O3I_026190 1.571e-20 99.0 COG0236@1|root,COG0236@2|Bacteria,2IEJY@201174|Actinobacteria 201174|Actinobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding GNS1_k127_3997207_5 644966.Tmar_0951 1.415e-101 345.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WCS5@538999|Clostridiales incertae sedis 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt GNS1_k127_3997207_9 1133849.O3I_026200 2.754e-52 203.0 COG0304@1|root,COG0304@2|Bacteria,2IACW@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt GNS1_k127_3997207_15 344747.PM8797T_12853 2.276e-14 79.0 COG0764@1|root,COG0764@2|Bacteria,2J09I@203682|Planctomycetes 203682|Planctomycetes I 3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein) - - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA GNS1_k127_3997207_4 1121468.AUBR01000030_gene1226 6.831e-111 374.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,42FCV@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt GNS1_k127_3997207_6 1128427.KB904821_gene3324 2.477e-69 245.0 COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1H8AU@1150|Oscillatoriales 1117|Cyanobacteria IQ with different specificities (related to short-chain alcohol fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GNS1_k127_3997207_12 479437.Elen_2209 3.111e-22 102.0 COG0736@1|root,COG0736@2|Bacteria,2HT7V@201174|Actinobacteria,4CVSA@84998|Coriobacteriia 84998|Coriobacteriia I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS GNS1_k127_3997207_13 1246626.BleG1_3694 5.946e-22 101.0 COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,4HGX1@91061|Bacilli,1ZFJ9@1386|Bacillus 91061|Bacilli I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA GNS1_k127_3997207_7 1133849.O3I_026235 3.718e-59 224.0 COG0304@1|root,COG0304@2|Bacteria,2IACW@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt GNS1_k127_3997207_11 671143.DAMO_1642 1.102e-36 151.0 COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria 2|Bacteria M Lipid A biosynthesis - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans GNS1_k127_3997207_0 671143.DAMO_0098 0.0 1137.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec GNS1_k127_3997207_8 671143.DAMO_2794 7.07e-53 207.0 COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase icfG - 2.7.13.3,3.1.3.3,4.6.1.1 ko:K01768,ko:K02482,ko:K02660,ko:K03406,ko:K05874,ko:K07315,ko:K10819,ko:K11525,ko:K11617 ko00230,ko02020,ko02025,ko02030,ko04113,ko04213,map00230,map02020,map02025,map02030,map04113,map04213 M00481,M00695,M00754 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044,ko03021 - - - EAL,GGDEF,Guanylate_cyc,HAMP,HATPase_c,HisKA,MCPsignal,SpoIIE,dCache_1 GNS1_k127_3997207_2 671143.DAMO_0100 1.017e-218 691.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system atoC - - ko:K02481,ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_3997207_1 671143.DAMO_0102 2.321e-232 729.0 COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria 2|Bacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec GNS1_k127_4055559_8 1382306.JNIM01000001_gene536 9.383e-78 271.0 COG2079@1|root,COG2079@2|Bacteria 2|Bacteria S 2-methylcitrate dehydratase activity - - - - - - - - - - - - MmgE_PrpD GNS1_k127_4055559_10 558169.AGAV01000005_gene2556 9.594e-38 148.0 COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,4HEZJ@91061|Bacilli 91061|Bacilli S protein involved in propionate catabolism - - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD GNS1_k127_4055559_7 796606.BMMGA3_07950 1.412e-86 303.0 COG0584@1|root,COG3540@1|root,COG0584@2|Bacteria,COG3540@2|Bacteria,1UY23@1239|Firmicutes,4HEAD@91061|Bacilli,1ZCIE@1386|Bacillus 91061|Bacilli C glycerophosphoryl diester phosphodiesterase glpQ - 3.1.3.1,3.1.4.46 ko:K01113,ko:K01126 ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020 M00126 R01030,R01470,R04620 RC00017,RC00425 ko00000,ko00001,ko00002,ko01000 - - - GDPD GNS1_k127_4055559_0 671143.DAMO_3123 7.74e-226 706.0 COG2204@1|root,COG2204@2|Bacteria,2NQHI@2323|unclassified Bacteria 2|Bacteria T Sigma-54 interaction domain - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_4055559_1 671143.DAMO_3124 6.63e-196 626.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,SpoIIE,sCache_3_2 GNS1_k127_4055559_5 1379698.RBG1_1C00001G0407 4.733e-127 421.0 COG0823@1|root,COG0823@2|Bacteria,2NQA4@2323|unclassified Bacteria 2|Bacteria U Periplasmic component of the Tol biopolymer transport system tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PA,PD40,PDZ_2,Peptidase_M28 GNS1_k127_4055559_3 404589.Anae109_2846 1.327e-138 469.0 COG0750@1|root,COG2234@1|root,COG0750@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,42Z17@68525|delta/epsilon subdivisions,2WURE@28221|Deltaproteobacteria,2YUPJ@29|Myxococcales 28221|Deltaproteobacteria O Peptidase family M28 - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 GNS1_k127_4055559_6 671143.DAMO_3125 1.306e-87 296.0 COG0494@1|root,COG0494@2|Bacteria,2NPTC@2323|unclassified Bacteria 2|Bacteria L NUDIX domain nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS05505,iSB619.SA_RS07540,iYO844.BSU23610 NUDIX GNS1_k127_4055559_4 671143.DAMO_3126 5.348e-133 430.0 COG2267@1|root,COG2267@2|Bacteria,2NQ6U@2323|unclassified Bacteria 2|Bacteria I Alpha/beta hydrolase family - - 3.7.1.17 ko:K16050 ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220 - R09883 RC02018,RC02740 ko00000,ko00001,ko01000 - - - Abhydrolase_1 GNS1_k127_4055559_15 1499967.BAYZ01000086_gene5170 6.086e-06 52.0 COG0457@1|root,COG0457@2|Bacteria 1499967.BAYZ01000086_gene5170|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GNS1_k127_4055559_2 671143.DAMO_3127 1.034e-172 550.0 COG1408@1|root,COG1408@2|Bacteria,2NRGP@2323|unclassified Bacteria 2|Bacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07098 - - - - ko00000 - - - Metallophos GNS1_k127_4055559_9 671143.DAMO_3128 1.822e-56 198.0 COG0730@1|root,COG0730@2|Bacteria,2NRPD@2323|unclassified Bacteria 2|Bacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE GNS1_k127_4055559_12 1346791.M529_10880 2.03e-24 110.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2K0W5@204457|Sphingomonadales 204457|Sphingomonadales S synthesis repressor PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N GNS1_k127_4055559_14 526225.Gobs_2424 2.845e-09 59.0 COG0332@1|root,COG0332@2|Bacteria,2IAG3@201174|Actinobacteria,4EUGQ@85013|Frankiales 201174|Actinobacteria I PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III domain protein - - - - - - - - - - - - ACP_syn_III,ACP_syn_III_C GNS1_k127_410584_1 671143.DAMO_2984 2.244e-123 405.0 2BHGH@1|root,32BIN@2|Bacteria,2NRSQ@2323|unclassified Bacteria 2|Bacteria S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 GNS1_k127_410584_6 521011.Mpal_1491 2.998e-32 137.0 arCOG01662@1|root,arCOG01662@2157|Archaea,2XX49@28890|Euryarchaeota,2N9SA@224756|Methanomicrobia 224756|Methanomicrobia S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 GNS1_k127_410584_9 378806.STAUR_1951 3.932e-07 61.0 COG0457@1|root,COG0457@2|Bacteria,1PEH7@1224|Proteobacteria,42TVC@68525|delta/epsilon subdivisions,2WSCX@28221|Deltaproteobacteria,2YZCB@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11,TPR_14,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8 GNS1_k127_410584_10 429009.Adeg_0040 0.0001221 50.0 COG2250@1|root,COG2250@2|Bacteria,1V8IG@1239|Firmicutes,24J9F@186801|Clostridia,42ICS@68295|Thermoanaerobacterales 186801|Clostridia S SMART HEPN domain protein - - - - - - - - - - - - HEPN GNS1_k127_410584_8 1131269.AQVV01000200_gene1603 4.781e-14 77.0 2DESJ@1|root,2ZP2P@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_410584_2 1121468.AUBR01000012_gene2590 2.208e-97 331.0 COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,42EQS@68295|Thermoanaerobacterales 1239|Firmicutes O PFAM peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 GNS1_k127_410584_3 1121468.AUBR01000012_gene2591 5.106e-88 303.0 COG0826@1|root,COG0826@2|Bacteria 2|Bacteria O peptidase U32 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 GNS1_k127_410584_4 671143.DAMO_2360 1.056e-47 183.0 COG0826@1|root,COG0826@2|Bacteria,2NPQH@2323|unclassified Bacteria 2|Bacteria O Evidence 5 No homology to any previously reported sequences - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32,Peptidase_U32_C GNS1_k127_410584_5 1121430.JMLG01000002_gene1096 2.44e-34 143.0 COG1414@1|root,COG1414@2|Bacteria,1V5M5@1239|Firmicutes,24XQ7@186801|Clostridia 186801|Clostridia K helix_turn_helix isocitrate lyase regulation - - - - - - - - - - - - HTH_IclR,IclR GNS1_k127_410584_0 1121468.AUBR01000012_gene2593 3.269e-200 636.0 COG0365@1|root,COG0365@2|Bacteria,1UMN9@1239|Firmicutes,25GME@186801|Clostridia 186801|Clostridia I AMP-binding enzyme C-terminal domain - - 6.2.1.32 ko:K08295 ko00627,ko01120,map00627,map01120 - R00982 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C GNS1_k127_4136289_3 671143.DAMO_2142 5.277e-164 517.0 COG0458@1|root,COG0458@2|Bacteria,2NNPB@2323|unclassified Bacteria 2|Bacteria EF Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS GNS1_k127_4136289_4 671143.DAMO_2141 3.717e-102 336.0 COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria 2|Bacteria S Methyltransferase domain yrrM - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 GNS1_k127_4136289_1 671143.DAMO_2140 1.876e-214 670.0 COG0505@1|root,COG0505@2|Bacteria,2NNMS@2323|unclassified Bacteria 2|Bacteria F Belongs to the CarA family carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1383 CPSase_sm_chain,GATase GNS1_k127_4136289_0 671143.DAMO_2139 1.039e-228 715.0 COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria 2|Bacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 GNS1_k127_4136289_2 671143.DAMO_2138 3.961e-166 531.0 COG0540@1|root,COG0540@2|Bacteria,2NNPZ@2323|unclassified Bacteria 2|Bacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU15490 OTCace,OTCace_N GNS1_k127_4136289_5 671143.DAMO_2137 1.112e-92 307.0 COG2065@1|root,COG2065@2|Bacteria,2NPF2@2323|unclassified Bacteria 2|Bacteria F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - iHN637.CLJU_RS05275 Pribosyltran GNS1_k127_4136289_9 1123023.JIAI01000001_gene6005 1.431e-18 91.0 COG3467@1|root,COG3467@2|Bacteria,2IFJS@201174|Actinobacteria,4E6D0@85010|Pseudonocardiales 201174|Actinobacteria S Pyridoxamine 5'-phosphate oxidase - - - - - - - - - - - - Putative_PNPOx GNS1_k127_4136289_7 671143.DAMO_2136 4.037e-38 145.0 2EM0R@1|root,33EQ9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_4136289_6 671143.DAMO_2134 8.078e-78 263.0 COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria 2|Bacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 2.7.7.7,6.5.1.2 ko:K01972,ko:K02342,ko:K04096,ko:K12472 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,ko04144,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440,map04144 M00260 R00375,R00376,R00377,R00378,R00382 RC00005,RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400,ko04131 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5,RNase_T GNS1_k127_4194375_0 671143.DAMO_3080 6.384e-268 829.0 COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria 2|Bacteria O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C GNS1_k127_4194375_3 478741.JAFS01000001_gene2215 1.309e-80 281.0 2BYEC@1|root,32U9Q@2|Bacteria,46ZC2@74201|Verrucomicrobia,37G9A@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - GNS1_k127_4194375_2 204669.Acid345_3923 1.636e-88 306.0 COG2223@1|root,COG2223@2|Bacteria,3Y3PZ@57723|Acidobacteria,2JICB@204432|Acidobacteriia 2|Bacteria P Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1,Sugar_tr GNS1_k127_4194375_1 671143.DAMO_2706 8.531e-163 519.0 COG1009@1|root,COG1009@2|Bacteria,2NNM8@2323|unclassified Bacteria 2|Bacteria CP NADH-quinone oxidoreductase chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N GNS1_k127_4195643_2 671143.DAMO_2301 3.717e-196 619.0 COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria 2|Bacteria M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4,6.3.2.8 ko:K01921,ko:K01924 ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502 - R01150,R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N,Mur_ligase,Mur_ligase_C,Mur_ligase_M GNS1_k127_4195643_1 671143.DAMO_2302 7.905e-241 756.0 COG0770@1|root,COG0770@2|Bacteria,2NP4Q@2323|unclassified Bacteria 2|Bacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M GNS1_k127_4195643_4 671143.DAMO_2303 8.263e-107 351.0 COG2267@1|root,COG2267@2|Bacteria,2NPU3@2323|unclassified Bacteria 2|Bacteria I Alpha/beta hydrolase family acoC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Biotin_lipoyl,E3_binding GNS1_k127_4195643_3 1123288.SOV_1c09950 3.669e-136 450.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,4H2VD@909932|Negativicutes 909932|Negativicutes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 - R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M GNS1_k127_4195643_0 671143.DAMO_2305 1.697e-262 820.0 COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria 2|Bacteria M Penicillin-binding Protein dimerisation domain ftsI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase GNS1_k127_4195643_5 671143.DAMO_2306 6.816e-16 78.0 2DT1T@1|root,33IAD@2|Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - FtsL GNS1_k127_423371_0 671143.DAMO_0645 3.253e-154 492.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GNS1_k127_423371_3 1009370.ALO_21344 9.347e-85 288.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4H217@909932|Negativicutes 909932|Negativicutes I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 GNS1_k127_423371_4 1123405.AUMM01000004_gene705 1.349e-35 143.0 COG1309@1|root,COG1309@2|Bacteria,1UVMZ@1239|Firmicutes,4I434@91061|Bacilli,26Q3M@186821|Sporolactobacillaceae 91061|Bacilli K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N GNS1_k127_423371_1 671143.DAMO_0838 1.296e-145 469.0 COG1131@1|root,COG1131@2|Bacteria,2NNKB@2323|unclassified Bacteria 2|Bacteria V AAA domain, putative AbiEii toxin, Type IV TA system ccmA - 3.6.3.7 ko:K01990,ko:K09697 ko02010,ko02020,map02010,map02020 M00253,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.115 - - ABC_tran GNS1_k127_423371_2 671143.DAMO_0837 6.607e-107 351.0 COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria 2|Bacteria S ABC-2 family transporter protein yxlG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux GNS1_k127_4237698_2 671143.DAMO_0003 2.684e-28 116.0 COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria 2|Bacteria O Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD GNS1_k127_4237698_1 671143.DAMO_0004 9.553e-211 662.0 COG0612@1|root,COG0612@2|Bacteria,2NPE5@2323|unclassified Bacteria 2|Bacteria S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C GNS1_k127_4237698_0 671143.DAMO_0005 2.028e-223 696.0 COG0612@1|root,COG0612@2|Bacteria,2NP50@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C GNS1_k127_424066_1 671143.DAMO_2077 6.3e-147 470.0 COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 - R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf GNS1_k127_424066_0 671143.DAMO_2078 1.552e-174 554.0 COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 GNS1_k127_424066_2 671143.DAMO_2079 2.691e-62 221.0 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity tonB3 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2,TonB_C GNS1_k127_441295_0 671143.DAMO_0098 5.933e-133 442.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec GNS1_k127_441295_2 1499967.BAYZ01000163_gene6611 3.35e-25 115.0 COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria 2|Bacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,HATPase_c,PAS_4,PAS_9,Response_reg GNS1_k127_441295_1 671143.DAMO_0480 3.3e-63 224.0 COG2203@1|root,COG4191@1|root,COG5000@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,2NQWP@2323|unclassified Bacteria 2|Bacteria T GAF domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,Response_reg,dCache_1 GNS1_k127_4475689_0 671143.DAMO_1865 0.0 1056.0 COG0441@1|root,COG0441@2|Bacteria,2NNMT@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD GNS1_k127_4475689_3 671143.DAMO_1864 5.405e-85 284.0 COG0290@1|root,COG0290@2|Bacteria,2NPDH@2323|unclassified Bacteria 2|Bacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N GNS1_k127_4475689_5 671143.DAMO_1863 2.381e-29 117.0 COG0291@1|root,COG0291@2|Bacteria,2NQ3J@2323|unclassified Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p GNS1_k127_4475689_4 671143.DAMO_1862 3.425e-52 186.0 COG0292@1|root,COG0292@2|Bacteria,2NPQQ@2323|unclassified Bacteria 2|Bacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 GNS1_k127_4475689_1 671143.DAMO_1861 2.099e-192 604.0 COG0016@1|root,COG0016@2|Bacteria,2NNNT@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d GNS1_k127_4475689_2 671143.DAMO_1857 2.837e-133 431.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2NNXI@2323|unclassified Bacteria 2|Bacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind GNS1_k127_4520387_2 1125863.JAFN01000001_gene2174 1.835e-33 136.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1NS8H@1224|Proteobacteria,42YG4@68525|delta/epsilon subdivisions,2WU95@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. mcp40H-1 - - - - - - - - - - - GAF,GAF_2,MCPsignal GNS1_k127_4520387_0 1131269.AQVV01000014_gene185 7.93e-223 731.0 COG3002@1|root,COG3002@2|Bacteria 2|Bacteria P Belongs to the UPF0753 family - - - ko:K09822 - - - - ko00000 - - - DUF2309 GNS1_k127_4520387_1 671143.DAMO_2706 3.182e-48 186.0 COG1009@1|root,COG1009@2|Bacteria,2NNM8@2323|unclassified Bacteria 2|Bacteria CP NADH-quinone oxidoreductase chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N GNS1_k127_4522625_1 671143.DAMO_2884 2.75e-310 956.0 COG0296@1|root,COG0296@2|Bacteria 2|Bacteria G 1,4-alpha-glucan branching enzyme activity glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18,3.2.1.141 ko:K00700,ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 GNS1_k127_4522625_8 671143.DAMO_1531 3.33e-71 248.0 COG1877@1|root,COG1877@2|Bacteria,2NPXY@2323|unclassified Bacteria 2|Bacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K01087,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Glyco_hydro_15,Glyco_transf_20,Trehalose_PPase GNS1_k127_4522625_2 1379698.RBG1_1C00001G0655 1.055e-283 889.0 COG0380@1|root,COG0380@2|Bacteria,2NPDG@2323|unclassified Bacteria 2|Bacteria G Glycosyltransferase family 20 otsA - 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 ko:K00697,ko:K13057,ko:K20436 ko00500,ko00525,ko01100,ko01130,map00500,map00525,map01100,map01130 M00815 R02737,R08946,R10525,R11239,R11250,R11306,R11497 RC00005,RC00049,RC02748,RC03400,RC03401 ko00000,ko00001,ko00002,ko01000,ko01003 - GT20,GT4 - Glyco_transf_20 GNS1_k127_4522625_4 909663.KI867151_gene3002 1.719e-142 462.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 GNS1_k127_4522625_9 909663.KI867151_gene3001 6.706e-36 144.0 COG0438@1|root,COG0438@2|Bacteria,1RA8H@1224|Proteobacteria,42RMM@68525|delta/epsilon subdivisions,2WNQY@28221|Deltaproteobacteria,2MQWR@213462|Syntrophobacterales 28221|Deltaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - GNS1_k127_4522625_12 289376.THEYE_A1803 1.691e-06 53.0 28U9C@1|root,2ZGEW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_4522625_11 671143.DAMO_2634 3.936e-14 75.0 COG5416@1|root,COG5416@2|Bacteria 2|Bacteria FG Lipopolysaccharide assembly protein A domain yrvD - - ko:K08992 - - - - ko00000 - - - LapA_dom GNS1_k127_4522625_3 671143.DAMO_2633 2.192e-216 678.0 COG1253@1|root,COG1253@2|Bacteria,2NP04@2323|unclassified Bacteria 2|Bacteria S Transporter associated domain ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03699,ko:K06189 - - - - ko00000,ko02000,ko02042 9.A.40.1.2 - - CBS,CorC_HlyC,DUF21,TerC GNS1_k127_4522625_0 671143.DAMO_2632 0.0 1075.0 COG1449@1|root,COG1449@2|Bacteria,2NQCA@2323|unclassified Bacteria 2|Bacteria G Domain of unknown function (DUF3536) - - - - - - - - - - - - DUF3536,Glyco_hydro_57 GNS1_k127_4522625_5 671143.DAMO_2631 5.829e-141 455.0 COG1463@1|root,COG1463@2|Bacteria,2NPXJ@2323|unclassified Bacteria 2|Bacteria Q MlaD protein ttg2C - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD GNS1_k127_4522625_7 671143.DAMO_2630 9.648e-122 394.0 COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran GNS1_k127_4522625_6 671143.DAMO_2629 7.971e-133 426.0 COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE GNS1_k127_4522625_10 671143.DAMO_2628 4.783e-28 114.0 2ENGZ@1|root,33G4G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_454439_5 671143.DAMO_1038 7.272e-31 124.0 COG1135@1|root,COG1135@2|Bacteria 2|Bacteria P methionine transport - - - ko:K02071 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - Fer4,NIL GNS1_k127_454439_0 671143.DAMO_1039 9.969e-245 759.0 COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria 2|Bacteria E Threonine synthase thrC1 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP GNS1_k127_454439_3 671143.DAMO_1040 9.226e-46 166.0 COG1977@1|root,COG1977@2|Bacteria,2NRPZ@2323|unclassified Bacteria 2|Bacteria H ThiS family - - 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - ThiS GNS1_k127_454439_6 330214.NIDE1240 8.588e-07 53.0 COG2768@1|root,COG2768@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF2088,DUF362 GNS1_k127_454439_1 1385935.N836_16325 1.729e-145 475.0 COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria,1H9SQ@1150|Oscillatoriales 1117|Cyanobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.18,2.6.1.62 ko:K00822,ko:K00833 ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100 M00123,M00573,M00577 R00907,R03231,R04187 RC00006,RC00008,RC00062,RC00160,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 GNS1_k127_454439_2 671143.DAMO_0834 2.253e-120 390.0 COG1183@1|root,COG1183@2|Bacteria,2NR1K@2323|unclassified Bacteria 2|Bacteria I phosphatidylcholine synthase activity pcs GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576 2.7.8.24,2.7.8.8 ko:K01004,ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800,R05794 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf GNS1_k127_454439_4 671143.DAMO_0835 4.532e-31 132.0 2DN50@1|root,32VJ4@2|Bacteria,2NQ0E@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 GNS1_k127_4741273_15 933262.AXAM01000019_gene1129 5.114e-20 90.0 COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions,2WMCC@28221|Deltaproteobacteria,2MIZZ@213118|Desulfobacterales 28221|Deltaproteobacteria S beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B_2 GNS1_k127_4741273_3 671143.DAMO_0507 9.678e-179 562.0 COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria 2|Bacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N GNS1_k127_4741273_6 671143.DAMO_0508 4.131e-81 284.0 COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C GNS1_k127_4741273_8 671143.DAMO_0509 5.27e-72 247.0 COG0193@1|root,COG0193@2|Bacteria,2NPQ7@2323|unclassified Bacteria 2|Bacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro GNS1_k127_4741273_12 671143.DAMO_0510 5.467e-49 178.0 COG0360@1|root,COG0360@2|Bacteria,2NQ1Q@2323|unclassified Bacteria 2|Bacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 4.3.1.19 ko:K01754,ko:K02990 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010 M00178,M00570 R00220,R00996 RC00418,RC02600 br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029 - - - Ribosomal_S6 GNS1_k127_4741273_10 671143.DAMO_0511 1.093e-64 224.0 COG0629@1|root,COG0629@2|Bacteria,2NPP5@2323|unclassified Bacteria 2|Bacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB GNS1_k127_4741273_14 671143.DAMO_0512 2.638e-35 135.0 COG0238@1|root,COG0238@2|Bacteria,2NPTU@2323|unclassified Bacteria 2|Bacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 GNS1_k127_4741273_5 671143.DAMO_0513 4.646e-110 364.0 COG4241@1|root,COG4241@2|Bacteria 2|Bacteria S Predicted membrane protein (DUF2232) yybS - - ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - DUF2232 GNS1_k127_4741273_11 671143.DAMO_0514 2.928e-63 220.0 COG0359@1|root,COG0359@2|Bacteria,2NPX4@2323|unclassified Bacteria 2|Bacteria J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N GNS1_k127_4741273_0 671143.DAMO_0515 1.091e-244 764.0 COG0305@1|root,COG0305@2|Bacteria,2NNKG@2323|unclassified Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C GNS1_k127_4741273_2 671143.DAMO_0516 1.599e-221 694.0 COG1066@1|root,COG1066@2|Bacteria,2NNQG@2323|unclassified Bacteria 2|Bacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C GNS1_k127_4741273_7 671143.DAMO_0518 3.483e-72 246.0 COG1329@1|root,COG1329@2|Bacteria,2NPWZ@2323|unclassified Bacteria 2|Bacteria K CarD-like/TRCF domain carD GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF GNS1_k127_4741273_4 671143.DAMO_0519 6.233e-157 501.0 COG4956@1|root,COG4956@2|Bacteria,2NP0D@2323|unclassified Bacteria 2|Bacteria S Large family of predicted nucleotide-binding domains yacL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - PIN,PIN_4,TRAM GNS1_k127_4741273_9 868595.Desca_0181 1.095e-65 232.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,261YY@186807|Peptococcaceae 186801|Clostridia I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20335 IspD GNS1_k127_4741273_13 555079.Toce_2117 2.212e-46 172.0 COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,42FTZ@68295|Thermoanaerobacterales 186801|Clostridia I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB GNS1_k127_4741273_1 671143.DAMO_0522 1.497e-221 702.0 COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECUMN_1333.ECUMN_0566,iJN746.PP_2905 DALR_2,tRNA-synt_1e,tRNA-synt_1g GNS1_k127_4741273_16 671143.DAMO_0523 1.979e-06 49.0 COG0566@1|root,COG0566@2|Bacteria,2NPDE@2323|unclassified Bacteria 2|Bacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind GNS1_k127_4744017_2 335543.Sfum_3172 6.172e-59 207.0 COG3829@1|root,COG3829@2|Bacteria,1QVJM@1224|Proteobacteria,43CC9@68525|delta/epsilon subdivisions,2X7N5@28221|Deltaproteobacteria 28221|Deltaproteobacteria KT PAS sensor protein - - - - - - - - - - - - PAS_4 GNS1_k127_4744017_0 1120950.KB892708_gene4177 1.135e-87 299.0 COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4DWSG@85009|Propionibacteriales 201174|Actinobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 GNS1_k127_4744017_1 880073.Calab_0535 3.442e-82 280.0 COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria 2|Bacteria I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 GNS1_k127_4744017_4 768671.ThimaDRAFT_4838 7.709e-11 66.0 COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,1SYRE@1236|Gammaproteobacteria,1X1HE@135613|Chromatiales 135613|Chromatiales O Redoxin - - - - - - - - - - - - AhpC-TSA GNS1_k127_4744017_3 502025.Hoch_3949 1.058e-56 206.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2X3AE@28221|Deltaproteobacteria,2YV4E@29|Myxococcales 28221|Deltaproteobacteria S nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - - - - - - - - - - MoCF_biosynth GNS1_k127_4816211_6 1330700.JQNC01000001_gene2250 2.329e-09 60.0 COG2026@1|root,COG2026@2|Bacteria,1WN9J@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus DJ ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin GNS1_k127_4816211_8 755178.Cyan10605_3158 0.0003415 46.0 COG4118@1|root,COG4118@2|Bacteria,1G7T7@1117|Cyanobacteria 1117|Cyanobacteria D Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox GNS1_k127_4816211_9 870187.Thini_1089 0.0007338 47.0 2D3E2@1|root,32TET@2|Bacteria,1N2S5@1224|Proteobacteria,1SBU9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Antitoxin component of a toxin-antitoxin (TA) module - - - - - - - - - - - - PhdYeFM_antitox GNS1_k127_4816211_4 1047013.AQSP01000088_gene1638 2.957e-16 80.0 2E9PU@1|root,333W6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - RHH_3 GNS1_k127_4816211_0 378806.STAUR_8277 1.267e-151 489.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria,2YWKY@29|Myxococcales 28221|Deltaproteobacteria S Fic/DOC family - - - - - - - - - - - - Fic,Fic_N,HTH_24 GNS1_k127_4816211_5 671143.DAMO_2686 2.853e-11 67.0 COG2026@1|root,COG2026@2|Bacteria 2|Bacteria DJ nuclease activity relE GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin GNS1_k127_4816211_7 330214.NIDE3688 3.367e-08 59.0 COG2161@1|root,COG2161@2|Bacteria 2|Bacteria D toxin-antitoxin pair type II binding relF GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 - - - PhdYeFM_antitox GNS1_k127_4816211_2 671143.DAMO_1713 6.187e-88 296.0 COG1678@1|root,COG1678@2|Bacteria 2|Bacteria K ribonucleoside-diphosphate reductase activity MA20_18155 - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 GNS1_k127_4816211_3 765911.Thivi_1938 4.175e-32 127.0 COG2827@1|root,COG2827@2|Bacteria,1MZ4K@1224|Proteobacteria 1224|Proteobacteria L endonuclease containing a URI domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG GNS1_k127_4816211_1 335543.Sfum_1461 7.251e-89 298.0 COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,2MQWV@213462|Syntrophobacterales 28221|Deltaproteobacteria N Protein of unknown function (DUF2950) - - - - - - - - - - - - DUF2950 GNS1_k127_4842220_3 671143.DAMO_0503 7.529e-149 480.0 COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2NPEN@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - ko:K11935 ko02026,map02026 - - - ko00000,ko00001 - - - TPR_1,TPR_15,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8 GNS1_k127_4842220_6 671143.DAMO_0502 9.044e-87 291.0 COG0218@1|root,COG0218@2|Bacteria,2NPMT@2323|unclassified Bacteria 2|Bacteria D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 GNS1_k127_4842220_2 671143.DAMO_0501 7.975e-185 582.0 COG0473@1|root,COG0473@2|Bacteria,2NP1R@2323|unclassified Bacteria 2|Bacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh GNS1_k127_4842220_10 671143.DAMO_0500 2.392e-52 192.0 COG3305@1|root,COG3305@2|Bacteria 2|Bacteria S Predicted membrane protein (DUF2127) - - - - - - - - - - - - DUF2127 GNS1_k127_4842220_7 671143.DAMO_0499 6.438e-83 301.0 COG1729@1|root,COG1729@2|Bacteria,2NQ0B@2323|unclassified Bacteria 2|Bacteria S Outer membrane lipoprotein - - - - - - - - - - - - TPR_16,TPR_6 GNS1_k127_4842220_11 671143.DAMO_0498 9.959e-50 190.0 COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria 2|Bacteria M OmpA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA GNS1_k127_4842220_1 671143.DAMO_0497 5.125e-226 708.0 COG0823@1|root,COG0823@2|Bacteria,2NNZC@2323|unclassified Bacteria 2|Bacteria U TolB amino-terminal domain tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N GNS1_k127_4842220_9 671143.DAMO_0496 1.377e-66 241.0 COG0810@1|root,COG0810@2|Bacteria,2NQ3G@2323|unclassified Bacteria 2|Bacteria M TonB C terminal - - - ko:K03646,ko:K03832 - - - - ko00000,ko02000 2.C.1.1,2.C.1.2 - - CarbopepD_reg_2,TonB_2,TonB_C GNS1_k127_4842220_8 671143.DAMO_0495 1.693e-68 239.0 COG0848@1|root,COG0848@2|Bacteria,2NQ52@2323|unclassified Bacteria 2|Bacteria U Biopolymer transport protein ExbD/TolR tolR - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD GNS1_k127_4842220_5 671143.DAMO_0494 1.209e-109 358.0 COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB GNS1_k127_4842220_12 518766.Rmar_2225 5.126e-06 52.0 COG5660@1|root,COG5660@2|Bacteria,4PF9I@976|Bacteroidetes,1FKBP@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Putative zinc-finger - - - - - - - - - - - - zf-HC2 GNS1_k127_4842220_0 234267.Acid_3143 3.585e-247 781.0 COG3408@1|root,COG3408@2|Bacteria 2|Bacteria G Glycogen debranching enzyme glgX - - - - - - - - - - - GDE_C,GDE_N GNS1_k127_4842220_4 1121381.JNIV01000090_gene223 1.284e-118 391.0 COG1249@1|root,COG1249@2|Bacteria,1WM2Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim GNS1_k127_4844150_10 485913.Krac_8034 9.779e-40 152.0 COG3467@1|root,COG3467@2|Bacteria,2G70M@200795|Chloroflexi 200795|Chloroflexi S PFAM pyridoxamine 5'-phosphate oxidase-related - - - - - - - - - - - - Putative_PNPOx GNS1_k127_4844150_9 1232410.KI421426_gene1402 2.228e-45 172.0 COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,42TAG@68525|delta/epsilon subdivisions,2WPRH@28221|Deltaproteobacteria,43SJK@69541|Desulfuromonadales 28221|Deltaproteobacteria L NUDIX domain - - - - - - - - - - - - NUDIX GNS1_k127_4844150_7 671143.DAMO_0692 6.277e-95 314.0 COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria 2|Bacteria H GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 ko:K00950,ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R03503,R04639,R05046,R05048 RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.folE,iIT341.HP0928,iJN678.folE,iNJ661.Rv3609c GTP_cyclohydroI GNS1_k127_4844150_6 1382356.JQMP01000003_gene1909 2.26e-99 332.0 COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,27XJW@189775|Thermomicrobia 189775|Thermomicrobia D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA GNS1_k127_4844150_8 671143.DAMO_0691 4.699e-91 302.0 COG0521@1|root,COG0521@2|Bacteria,2NR7Z@2323|unclassified Bacteria 2|Bacteria H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth GNS1_k127_4844150_11 671143.DAMO_0690 9.672e-28 113.0 2E9C2@1|root,30ZT9@2|Bacteria,2NRQ4@2323|unclassified Bacteria 2|Bacteria S Pup-like protein - - - ko:K13570 - - - - ko00000,ko04121 - - - Pup GNS1_k127_4844150_12 671143.DAMO_0689 1.053e-15 79.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 GNS1_k127_4844150_4 264732.Moth_1781 8.018e-113 371.0 COG0616@1|root,COG0616@2|Bacteria,1U2Z9@1239|Firmicutes,24DAF@186801|Clostridia,42FQA@68295|Thermoanaerobacterales 186801|Clostridia OU Serine dehydrogenase proteinase - - - - - - - - - - - - SDH_sah GNS1_k127_4844150_5 247490.KSU1_C1365 3.278e-106 359.0 COG0508@1|root,COG0508@2|Bacteria,2IWRM@203682|Planctomycetes 203682|Planctomycetes C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding GNS1_k127_4844150_1 671143.DAMO_0747 5.132e-186 586.0 COG0022@1|root,COG0022@2|Bacteria,2NNT2@2323|unclassified Bacteria 2|Bacteria C Transketolase, pyrimidine binding domain bfmBA - 1.2.4.4 ko:K00167,ko:K11381,ko:K21417 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C GNS1_k127_4844150_2 671143.DAMO_0748 1.706e-168 534.0 COG1071@1|root,COG1071@2|Bacteria,2NPBB@2323|unclassified Bacteria 2|Bacteria C Dehydrogenase E1 component bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K00166,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C GNS1_k127_4844150_0 671143.DAMO_0749 0.0 1024.0 COG1222@1|root,COG2433@1|root,COG1222@2|Bacteria,COG2433@2|Bacteria,2NQB9@2323|unclassified Bacteria 2|Bacteria O Proteasomal ATPase OB/ID domain arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 2.7.13.3 ko:K07184,ko:K07777,ko:K12065,ko:K13525,ko:K13527 ko02020,ko03050,ko04141,ko05134,map02020,map03050,map04141,map05134 M00342,M00400,M00403,M00478 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044,ko03019,ko03051,ko04131,ko04147 3.A.16.1,3.A.7.11.1 - - AAA,Prot_ATP_ID_OB GNS1_k127_4844150_3 671143.DAMO_0750 9.205e-144 461.0 COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria 2|Bacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase GNS1_k127_4844200_3 671143.DAMO_0750 4.325e-81 271.0 COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria 2|Bacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase GNS1_k127_4844200_1 671143.DAMO_0751 2.821e-133 431.0 COG0638@1|root,COG0638@2|Bacteria,2NQJR@2323|unclassified Bacteria 2|Bacteria O Proteasome subunit prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome GNS1_k127_4844200_2 671143.DAMO_0752 5.311e-110 363.0 COG0638@1|root,COG0638@2|Bacteria,2NQRX@2323|unclassified Bacteria 2|Bacteria O Proteasome subunit - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome GNS1_k127_4844200_0 671143.DAMO_0753 6.058e-146 463.0 COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria 2|Bacteria O Pup-ligase protein pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase GNS1_k127_4858275_10 671143.DAMO_2996 2.234e-51 185.0 COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria 2|Bacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM GNS1_k127_4858275_12 671143.DAMO_0140 6.879e-11 62.0 COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria 2|Bacteria K 'Cold-shock' DNA-binding domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD GNS1_k127_4858275_4 671143.DAMO_2997 1.933e-109 363.0 COG4395@1|root,COG4395@2|Bacteria 2|Bacteria S Tim44 MA20_08550 - - ko:K15539 - - - - ko00000 - - - Tim44 GNS1_k127_4858275_9 1232410.KI421424_gene1749 2.482e-59 222.0 COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,43C4E@68525|delta/epsilon subdivisions,2X7EV@28221|Deltaproteobacteria,43S1I@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Dienelactone hydrolase - - - - - - - - - - - - - GNS1_k127_4858275_8 671143.DAMO_2843 1.732e-62 221.0 2DGXT@1|root,2ZXPG@2|Bacteria,2NRPI@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_4858275_7 671143.DAMO_2842 1.886e-69 245.0 COG5662@1|root,COG5662@2|Bacteria 2|Bacteria K AntiSigma factor - - - - - - - - - - - - zf-HC2 GNS1_k127_4858275_6 671143.DAMO_2841 2.248e-91 302.0 COG1595@1|root,COG1595@2|Bacteria,2NPR9@2323|unclassified Bacteria 2|Bacteria K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GNS1_k127_4858275_1 671143.DAMO_2839 1.128e-228 719.0 COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_4858275_0 671143.DAMO_2838 6.254e-238 744.0 COG4191@1|root,COG4191@2|Bacteria,2NQ9P@2323|unclassified Bacteria 2|Bacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA GNS1_k127_4858275_5 671143.DAMO_2825 2.13e-94 316.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 GNS1_k127_4858275_2 671143.DAMO_2824 1.233e-181 578.0 COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 GNS1_k127_4858275_3 671143.DAMO_2823 3.576e-127 411.0 COG1801@1|root,COG1801@2|Bacteria 2|Bacteria L Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 GNS1_k127_4858275_11 1385514.N782_10395 5.641e-17 86.0 2E9CG@1|root,333K5@2|Bacteria,1V87Y@1239|Firmicutes,4HIGZ@91061|Bacilli,2YBUQ@289201|Pontibacillus 91061|Bacilli - - - - - - - - - - - - - - TIMP GNS1_k127_4864741_4 671143.DAMO_2944 2.331e-19 89.0 COG0172@1|root,COG0172@2|Bacteria,2NNRH@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_3528,iSDY_1059.SDY_2368 Seryl_tRNA_N,tRNA-synt_2b GNS1_k127_4864741_0 671143.DAMO_2945 0.0 1409.0 COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV GNS1_k127_4864741_1 671143.DAMO_2946 0.0 1378.0 COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim GNS1_k127_4864741_2 671143.DAMO_2947 1.009e-180 571.0 COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria 2|Bacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 GNS1_k127_4864741_5 309799.DICTH_1849 3.568e-13 70.0 COG0230@1|root,COG0230@2|Bacteria 2|Bacteria J Ribosomal protein L34 rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 GNS1_k127_4864741_3 671143.DAMO_2951 3.807e-24 107.0 COG0759@1|root,COG0759@2|Bacteria,2NQ30@2323|unclassified Bacteria 2|Bacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD - - ko:K08998 - - - - ko00000 - - - Haemolytic GNS1_k127_4864741_6 56780.SYN_01014 6.251e-07 57.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MQBM@213462|Syntrophobacterales 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas GNS1_k127_4885261_5 671143.DAMO_1221 1.259e-39 153.0 COG5616@1|root,COG5616@2|Bacteria,2NRDS@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - ko:K03765 - - - - ko00000,ko03000 - - - CsgG,VCBS GNS1_k127_4885261_3 671143.DAMO_1220 1.763e-65 226.0 COG0346@1|root,COG0346@2|Bacteria,2NPRH@2323|unclassified Bacteria 2|Bacteria E Glyoxalase-like domain mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 GNS1_k127_4885261_6 452637.Oter_2018 5.177e-23 102.0 COG0399@1|root,COG0399@2|Bacteria,46X71@74201|Verrucomicrobia,3KA16@414999|Opitutae 414999|Opitutae J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP GNS1_k127_4885261_1 671143.DAMO_1219 3.895e-277 860.0 COG1884@1|root,COG1884@2|Bacteria,2NNP5@2323|unclassified Bacteria 2|Bacteria I Methylmalonyl-CoA mutase bhbA - 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase GNS1_k127_4885261_4 671143.DAMO_1218 1.509e-57 205.0 COG4770@1|root,COG4770@2|Bacteria,2NQ2B@2323|unclassified Bacteria 2|Bacteria I Biotin-lipoyl like mccA GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.1,6.4.1.3,6.4.1.4 ko:K01960,ko:K01965,ko:K01968 ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230 M00036,M00173,M00373,M00620,M00741 R00344,R01859,R04138 RC00040,RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 GNS1_k127_4885261_2 671143.DAMO_1217 1.843e-246 769.0 COG0439@1|root,COG0439@2|Bacteria,2NNKD@2323|unclassified Bacteria 2|Bacteria I carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 ko:K01961,ko:K01965,ko:K01968,ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00376,M00741 R00742,R01859,R04138,R04385 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 GNS1_k127_4885261_0 671143.DAMO_1216 1.536e-297 917.0 COG4799@1|root,COG4799@2|Bacteria,2NNWQ@2323|unclassified Bacteria 2|Bacteria I carboxyl transferase pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans GNS1_k127_4912264_4 671143.DAMO_1560 7.456e-113 367.0 COG1109@1|root,COG1109@2|Bacteria,2NNWU@2323|unclassified Bacteria 2|Bacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886,iSBO_1134.SBO_3206 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV GNS1_k127_4912264_5 671143.DAMO_1558 1.002e-108 357.0 COG0854@1|root,COG0854@2|Bacteria,2NPFY@2323|unclassified Bacteria 2|Bacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2564,iAF987.Gmet_1885,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390 PdxJ GNS1_k127_4912264_12 671143.DAMO_1557 4.791e-50 181.0 COG0736@1|root,COG0736@2|Bacteria,2NPTD@2323|unclassified Bacteria 2|Bacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 - - - ACPS GNS1_k127_4912264_0 671143.DAMO_1556 1.65e-237 744.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria 2|Bacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N GNS1_k127_4912264_3 243231.GSU2308 2.927e-174 558.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria 28221|Deltaproteobacteria C malic protein domain protein - - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic GNS1_k127_4912264_11 671143.DAMO_1555 9.341e-59 209.0 COG0802@1|root,COG0802@2|Bacteria,2NPU4@2323|unclassified Bacteria 2|Bacteria S Threonylcarbamoyl adenosine biosynthesis protein TsaE ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.1.221,5.1.1.1 ko:K01775,ko:K06925,ko:K07102 ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502 - R00401,R08968,R11024 RC00002,RC00078,RC00285 ko00000,ko00001,ko01000,ko01011,ko03016 - - - TsaE GNS1_k127_4912264_6 1125863.JAFN01000001_gene865 4.865e-97 335.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP-2 - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 GNS1_k127_4912264_14 644282.Deba_0841 1.979e-27 123.0 COG1102@1|root,COG2823@1|root,COG1102@2|Bacteria,COG2823@2|Bacteria,1N42J@1224|Proteobacteria,42TW4@68525|delta/epsilon subdivisions,2WQ5J@28221|Deltaproteobacteria 28221|Deltaproteobacteria F PFAM transport-associated - - - - - - - - - - - - BON,Cytidylate_kin2 GNS1_k127_4912264_13 710685.MycrhN_3209 1.151e-44 174.0 COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,237DD@1762|Mycobacteriaceae 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C GNS1_k127_4912264_2 671143.DAMO_1554 8.509e-202 634.0 COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria 2|Bacteria S Vacuole effluxer Atg22 like yxiO - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 GNS1_k127_4912264_7 671143.DAMO_1553 7.757e-94 314.0 COG1214@1|root,COG1214@2|Bacteria,2NPK8@2323|unclassified Bacteria 2|Bacteria O Glycoprotease family yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 GNS1_k127_4912264_10 671143.DAMO_1552 3.502e-62 218.0 COG0454@1|root,COG0456@2|Bacteria,2NPTV@2323|unclassified Bacteria 2|Bacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 GNS1_k127_4912264_8 768706.Desor_3029 7.182e-80 276.0 COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24H6N@186801|Clostridia,263YQ@186807|Peptococcaceae 186801|Clostridia H Belongs to the DapA family - - 4.1.3.16 ko:K18123 ko00330,ko00630,ko01100,map00330,map00630,map01100 - R00470,R00471 RC00307,RC00308 ko00000,ko00001,ko01000 - - - DHDPS GNS1_k127_4912264_15 671143.DAMO_1551 1.545e-24 103.0 COG2835@1|root,COG2835@2|Bacteria,2NQ60@2323|unclassified Bacteria 2|Bacteria S Trm112p-like protein - - - ko:K09791 - - - - ko00000 - - - Trm112p GNS1_k127_4912264_1 671143.DAMO_1550 7.697e-232 726.0 COG0008@1|root,COG0008@2|Bacteria,2NNMZ@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616,iIT341.HP0476 tRNA-synt_1c GNS1_k127_4912264_9 671143.DAMO_1549 4.029e-71 248.0 COG0782@1|root,COG0782@2|Bacteria,2NPT2@2323|unclassified Bacteria 2|Bacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N GNS1_k127_4987160_0 671143.DAMO_1081 1.582e-195 615.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2NPBQ@2323|unclassified Bacteria 2|Bacteria H Tetrapyrrole (Corrin/Porphyrin) Methylases cobA GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K01719,ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15755 HEM4,TP_methylase GNS1_k127_4987160_2 671143.DAMO_1080 1.007e-135 439.0 COG0181@1|root,COG0181@2|Bacteria,2NP8M@2323|unclassified Bacteria 2|Bacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 ko:K01749,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084,R03165,R03194 RC00003,RC00871,RC01861,RC02317 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iHN637.CLJU_RS15760,iPC815.YPO3849 Porphobil_deam,Porphobil_deamC GNS1_k127_4987160_1 671143.DAMO_1079 5.343e-170 539.0 COG0373@1|root,COG0373@2|Bacteria,2NP37@2323|unclassified Bacteria 2|Bacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492,ko:K10714 ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,ko02040,map00680,map00860,map01100,map01110,map01120,map01200,map02040 M00121 R04109,R08059 RC00055,RC00149,RC00202 ko00000,ko00001,ko00002,ko01000,ko02035 - - - GlutR_N,GlutR_dimer,Shikimate_DH GNS1_k127_5004794_5 671143.DAMO_0687 4.407e-17 80.0 COG4198@1|root,COG4198@2|Bacteria,2NNV0@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 GNS1_k127_5004794_1 671143.DAMO_0698 2.867e-117 380.0 COG1045@1|root,COG1045@2|Bacteria,2NPQG@2323|unclassified Bacteria 2|Bacteria E Bacterial transferase hexapeptide (six repeats) cysE GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS02865,iYO844.BSU00930 Hexapep,SATase_N GNS1_k127_5004794_2 592015.HMPREF1705_00922 1.595e-54 199.0 COG0177@1|root,COG0177@2|Bacteria,3TB1B@508458|Synergistetes 508458|Synergistetes L Base excision DNA repair protein - - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD GNS1_k127_5004794_0 671143.DAMO_0696 3.021e-201 641.0 COG0617@1|root,COG0617@2|Bacteria,2NPB4@2323|unclassified Bacteria 2|Bacteria J Poly A polymerase head domain cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974,ko:K07276,ko:K19545 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko01504,ko03016,ko03019 - - - Aminoglyc_resit,HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 GNS1_k127_5004794_4 314345.SPV1_10806 1.591e-29 122.0 COG1146@1|root,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding fdxA GO:0001666,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0009628,GO:0036293,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0075136 - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4 GNS1_k127_5006296_2 994479.GL877878_gene3444 1.307e-89 304.0 COG1235@1|root,COG1235@2|Bacteria,2HBMA@201174|Actinobacteria,4DZUU@85010|Pseudonocardiales 201174|Actinobacteria S May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 GNS1_k127_5006296_0 671143.DAMO_2793 4.343e-218 691.0 COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains atoC - - ko:K02481,ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_5006296_1 671143.DAMO_2794 2.839e-204 649.0 COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase icfG - 2.7.13.3,3.1.3.3,4.6.1.1 ko:K01768,ko:K02482,ko:K02660,ko:K03406,ko:K05874,ko:K07315,ko:K10819,ko:K11525,ko:K11617 ko00230,ko02020,ko02025,ko02030,ko04113,ko04213,map00230,map02020,map02025,map02030,map04113,map04213 M00481,M00695,M00754 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044,ko03021 - - - EAL,GGDEF,Guanylate_cyc,HAMP,HATPase_c,HisKA,MCPsignal,SpoIIE,dCache_1 GNS1_k127_5006296_3 555779.Dthio_PD1346 3.633e-18 89.0 293PF@1|root,2ZJ9Q@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_5091371_7 331678.Cphamn1_1869 3.374e-25 106.0 COG1968@1|root,COG1968@2|Bacteria,1FDGJ@1090|Chlorobi 1090|Chlorobi V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA GNS1_k127_5091371_2 671143.DAMO_1099 1.111e-207 653.0 COG0704@1|root,COG1392@1|root,COG0704@2|Bacteria,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria 2|Bacteria P Protein of unknown function DUF47 phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039,ko:K07220 - - - - ko00000 - - - PhoU,PhoU_div GNS1_k127_5091371_5 671143.DAMO_1100 5.914e-135 436.0 COG1117@1|root,COG1117@2|Bacteria,2NP2B@2323|unclassified Bacteria 2|Bacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran GNS1_k127_5091371_1 671143.DAMO_1101 1.494e-272 848.0 COG0581@1|root,COG0581@2|Bacteria,2NPJS@2323|unclassified Bacteria 2|Bacteria P phosphate transport system permease protein pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 GNS1_k127_5091371_0 671143.DAMO_1102 0.0 1134.0 COG4590@1|root,COG4590@2|Bacteria,2NS4H@2323|unclassified Bacteria 2|Bacteria U Binding-protein-dependent transport system inner membrane component pstC - - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 GNS1_k127_5091371_4 671143.DAMO_1103 1.126e-172 546.0 COG0226@1|root,COG0226@2|Bacteria,2NQMD@2323|unclassified Bacteria 2|Bacteria P PBP superfamily domain pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 GNS1_k127_5091371_3 671143.DAMO_1104 1.23e-206 653.0 COG3746@1|root,COG3746@2|Bacteria,2NRQ1@2323|unclassified Bacteria 2|Bacteria P phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P GNS1_k127_5091371_6 671143.DAMO_1105 3.872e-32 128.0 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding - - - - - - - - - - - - ANTAR,STAS_2 GNS1_k127_52028_6 671143.DAMO_1651 3.65e-119 389.0 COG1044@1|root,COG1044@2|Bacteria,2NNSF@2323|unclassified Bacteria 2|Bacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD GNS1_k127_52028_8 671143.DAMO_1650 8.136e-77 261.0 COG0764@1|root,COG0764@2|Bacteria,2NPK9@2323|unclassified Bacteria 2|Bacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 3.5.1.108,4.2.1.59 ko:K02372,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212 M00060,M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA GNS1_k127_52028_5 671143.DAMO_1649 4.641e-120 390.0 COG1043@1|root,COG1043@2|Bacteria,2NP5V@2323|unclassified Bacteria 2|Bacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep GNS1_k127_52028_4 671143.DAMO_1648 3.21e-121 395.0 COG3494@1|root,COG3494@2|Bacteria,2NR94@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1009) cdsA2 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748,ko:K09949 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - DUF1009 GNS1_k127_52028_2 671143.DAMO_1647 7.858e-163 516.0 COG0673@1|root,COG0673@2|Bacteria,2NNUQ@2323|unclassified Bacteria 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA GNS1_k127_52028_1 671143.DAMO_1646 1.097e-171 550.0 COG0763@1|root,COG0763@2|Bacteria,2NP10@2323|unclassified Bacteria 2|Bacteria I Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB GNS1_k127_52028_7 671143.DAMO_1645 3.363e-101 334.0 COG2121@1|root,COG2121@2|Bacteria,2NPP6@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 GNS1_k127_52028_0 671143.DAMO_1644 4.416e-192 608.0 COG1519@1|root,COG1519@2|Bacteria,2NP5A@2323|unclassified Bacteria 2|Bacteria M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N GNS1_k127_52028_3 671143.DAMO_1643 9.293e-144 473.0 COG1663@1|root,COG1663@2|Bacteria,2NPF0@2323|unclassified Bacteria 2|Bacteria M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 LpxK GNS1_k127_52028_9 671143.DAMO_1642 1.688e-11 68.0 COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria 2|Bacteria M Lipid A biosynthesis - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans GNS1_k127_52028_10 671143.DAMO_1641 0.0008483 42.0 COG0241@1|root,COG0859@1|root,COG0241@2|Bacteria,COG0859@2|Bacteria,2NPK4@2323|unclassified Bacteria 2|Bacteria E D,D-heptose 1,7-bisphosphate phosphatase rfaF - 2.7.1.167,2.7.7.70,3.1.3.82,3.1.3.83,5.3.1.28 ko:K02841,ko:K02843,ko:K02849,ko:K03271,ko:K03272,ko:K03273 ko00540,ko01100,map00540,map01100 M00064,M00080 R05644,R05645,R05646,R05647,R09768,R09769,R09771 RC00002,RC00017,RC00078,RC00434 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9,Hydrolase_like GNS1_k127_5358100_0 671143.DAMO_1261 0.0 1797.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran GNS1_k127_5358100_3 671143.DAMO_1260 1.299e-180 573.0 COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 GNS1_k127_5358100_9 671143.DAMO_1259 3.198e-94 312.0 COG1309@1|root,COG1309@2|Bacteria,2NQ8G@2323|unclassified Bacteria 2|Bacteria K Bacterial regulatory proteins, tetR family MA20_16815 - - - - - - - - - - - TetR_N GNS1_k127_5358100_6 671143.DAMO_1168 1.322e-99 331.0 COG3264@1|root,COG3264@2|Bacteria 2|Bacteria M cellular water homeostasis - - - ko:K03442,ko:K22044 - - - - ko00000,ko02000 1.A.23.2,1.A.23.3 - - MS_channel,TM_helix GNS1_k127_5358100_2 671143.DAMO_0699 9.164e-225 701.0 COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria 2|Bacteria G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2768 NTP_transferase GNS1_k127_5358100_1 671143.DAMO_1256 1.006e-308 952.0 COG0058@1|root,COG0058@2|Bacteria,2NNZS@2323|unclassified Bacteria 2|Bacteria G Carbohydrate phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase GNS1_k127_5358100_14 1242864.D187_003084 2.064e-47 181.0 COG2050@1|root,COG2050@2|Bacteria,1NGFY@1224|Proteobacteria,42UY5@68525|delta/epsilon subdivisions,2WSY5@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM thioesterase superfamily - - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT GNS1_k127_5358100_10 671143.DAMO_2097 1.734e-82 284.0 COG2853@1|root,COG2853@2|Bacteria,2NRQC@2323|unclassified Bacteria 2|Bacteria M MlaA lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA GNS1_k127_5358100_17 243231.GSU1129 7.099e-20 94.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UD9@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_5358100_4 330214.NIDE1256 1.864e-154 499.0 COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae 40117|Nitrospirae T Sigma-54 interaction domain - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_5358100_12 671143.DAMO_1544 3.118e-60 229.0 COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA GNS1_k127_5358100_16 1123073.KB899241_gene2124 8.757e-21 97.0 COG1917@1|root,COG1917@2|Bacteria,1RCXV@1224|Proteobacteria 1224|Proteobacteria S Cupin - - - - - - - - - - - - Cupin_2 GNS1_k127_5358100_7 1323361.JPOC01000038_gene4385 4.008e-99 332.0 COG0123@1|root,COG0123@2|Bacteria,2IDFT@201174|Actinobacteria,4G6HK@85025|Nocardiaceae 201174|Actinobacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl GNS1_k127_5358100_13 671143.DAMO_2537 2.922e-57 213.0 COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria 2|Bacteria M OmpA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA GNS1_k127_5358100_8 671143.DAMO_0499 2.904e-94 324.0 COG1729@1|root,COG1729@2|Bacteria,2NQ0B@2323|unclassified Bacteria 2|Bacteria S Outer membrane lipoprotein - - - - - - - - - - - - TPR_16,TPR_6 GNS1_k127_5358100_5 671143.DAMO_2102 1.044e-122 396.0 COG2887@1|root,COG2887@2|Bacteria,2NR12@2323|unclassified Bacteria 2|Bacteria L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K10742 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - AAA_24,PDDEXK_1 GNS1_k127_5358100_11 335543.Sfum_3094 8.742e-61 216.0 28HPC@1|root,2Z7XD@2|Bacteria,1PQBF@1224|Proteobacteria,42WX9@68525|delta/epsilon subdivisions,2WT62@28221|Deltaproteobacteria,2MSEC@213462|Syntrophobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4337) - - - - - - - - - - - - DUF4337 GNS1_k127_5358100_18 671143.DAMO_1250 6.978e-13 73.0 COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47,6.2.1.14 ko:K00639,ko:K00652,ko:K01906 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03209,R03210,R10124 RC00004,RC00014,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 GNS1_k127_5365983_1 518766.Rmar_2467 2.764e-126 414.0 COG2059@1|root,COG2059@2|Bacteria,4NNZ1@976|Bacteroidetes 976|Bacteroidetes P Chromate transporter, chromate ion transporter (CHR) family - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp GNS1_k127_5365983_3 671143.DAMO_3114 4.664e-115 374.0 COG0602@1|root,COG0602@2|Bacteria,2NPEM@2323|unclassified Bacteria 2|Bacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 - R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_1658 Fer4_14,Radical_SAM GNS1_k127_5365983_2 671143.DAMO_3113 7.796e-119 385.0 COG0603@1|root,COG0603@2|Bacteria,2NPD6@2323|unclassified Bacteria 2|Bacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_3075 QueC GNS1_k127_5365983_0 671143.DAMO_2896 0.0 1614.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria 2|Bacteria L UvrD/REP helicase N-terminal domain - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C GNS1_k127_5365983_4 671143.DAMO_2897 4.549e-85 286.0 COG5663@1|root,COG5663@2|Bacteria 2|Bacteria S phosphatase activity yqfW - - ko:K05967 - - - - ko00000 - - - NT5C GNS1_k127_5365983_6 926569.ANT_28190 2.735e-53 203.0 COG1322@1|root,COG1322@2|Bacteria 2|Bacteria S DNA recombination - - - ko:K09760 - - - - ko00000 - - - Apolipoprotein,RmuC GNS1_k127_5365983_5 671143.DAMO_2898 3.934e-68 243.0 COG1426@1|root,COG1426@2|Bacteria,2NQ7E@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4115) - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 GNS1_k127_5434882_1 1121396.KB893121_gene3060 5.43e-47 179.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MIMV@213118|Desulfobacterales 28221|Deltaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase GNS1_k127_5469941_4 671143.DAMO_2898 1.762e-29 121.0 COG1426@1|root,COG1426@2|Bacteria,2NQ7E@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4115) - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 GNS1_k127_5469941_0 671143.DAMO_2899 2.776e-136 442.0 COG1230@1|root,COG1230@2|Bacteria,2NPC3@2323|unclassified Bacteria 2|Bacteria U Cation efflux family czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer GNS1_k127_5469941_2 671143.DAMO_2902 6.782e-75 258.0 2CKY4@1|root,328RE@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_5469941_1 671143.DAMO_2903 8.723e-87 294.0 COG4659@1|root,COG4659@2|Bacteria 2|Bacteria C FMN binding rnfG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03612 - - - - ko00000 - - - FMN_bind GNS1_k127_5469941_3 671143.DAMO_2904 6.228e-51 183.0 COG2433@1|root,COG2433@2|Bacteria 2|Bacteria - - - - - ko:K12065 - - - - ko00000,ko02044 3.A.7.11.1 - - Porin_O_P GNS1_k127_5496620_0 671143.DAMO_2530 2.214e-118 402.0 COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 GNS1_k127_5496620_1 1392502.JNIO01000008_gene2860 6.946e-05 49.0 COG3018@1|root,COG3018@2|Bacteria,1V907@1239|Firmicutes,4H4Y8@909932|Negativicutes 909932|Negativicutes S LPP20 lipoprotein - - - - - - - - - - - - LPP20 GNS1_k127_5562211_4 671143.DAMO_3058 2.284e-47 171.0 COG1055@1|root,COG1055@2|Bacteria,2NQJ3@2323|unclassified Bacteria 2|Bacteria P Putative citrate transport arsB - - - - - - - - - - - CitMHS_2 GNS1_k127_5562211_1 671143.DAMO_3057 4.626e-68 240.0 COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria 2|Bacteria M OmpA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA GNS1_k127_5562211_0 671143.DAMO_2561 1.134e-71 245.0 COG0691@1|root,COG0691@2|Bacteria,2NPFK@2323|unclassified Bacteria 2|Bacteria O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - ko:K03664 - - - - ko00000 - - - SmpB GNS1_k127_5562211_2 479434.Sthe_0634 2.085e-58 207.0 COG5483@1|root,COG5483@2|Bacteria,2G8NZ@200795|Chloroflexi 200795|Chloroflexi S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 GNS1_k127_5562211_3 671143.DAMO_3115 3.082e-58 204.0 COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria 2|Bacteria O smart pdz dhr glgf degP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 GNS1_k127_5574768_4 671143.DAMO_1836 6.412e-18 84.0 COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria 2|Bacteria M Ami_3 amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 GNS1_k127_5574768_2 671143.DAMO_1835 1.241e-52 191.0 COG5401@1|root,COG5401@2|Bacteria,2NPV5@2323|unclassified Bacteria 2|Bacteria S Sporulation and spore germination - - - - - - - - - - - - Germane,Gmad2 GNS1_k127_5574768_0 671143.DAMO_1834 4.437e-130 422.0 COG0689@1|root,COG0689@2|Bacteria,2NP3K@2323|unclassified Bacteria 2|Bacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 - - - RNase_PH,RNase_PH_C GNS1_k127_5574768_1 671143.DAMO_1833 6.553e-73 251.0 COG0127@1|root,COG0127@2|Bacteria,2NPNJ@2323|unclassified Bacteria 2|Bacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 - R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 - - - Ham1p_like GNS1_k127_5574768_6 1121355.KB903379_gene745 2.203e-07 57.0 COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae 201174|Actinobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N GNS1_k127_5574768_3 391625.PPSIR1_35862 4.593e-32 131.0 COG0204@1|root,COG0204@2|Bacteria,1R72B@1224|Proteobacteria,433XW@68525|delta/epsilon subdivisions,2X411@28221|Deltaproteobacteria,2YXVN@29|Myxococcales 28221|Deltaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase GNS1_k127_5658254_18 1125863.JAFN01000001_gene578 1.287e-09 59.0 COG0784@1|root,COG0784@2|Bacteria,1QU3I@1224|Proteobacteria,43BYJ@68525|delta/epsilon subdivisions,2X79G@28221|Deltaproteobacteria 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg GNS1_k127_5658254_9 671143.DAMO_3018 2.01e-89 317.0 COG0642@1|root,COG2205@2|Bacteria 671143.DAMO_3018|- T PhoQ Sensor - - - - - - - - - - - - - GNS1_k127_5658254_16 1123504.JQKD01000020_gene5646 4.535e-14 74.0 COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria,4AA08@80864|Comamonadaceae 28216|Betaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B_2 GNS1_k127_5658254_21 185453.XP_006834427.1 3.106e-05 49.0 COG2220@1|root,KOG3798@2759|Eukaryota,39UP3@33154|Opisthokonta,3BFB2@33208|Metazoa,3CWR9@33213|Bilateria,47ZVI@7711|Chordata,48Z9Y@7742|Vertebrata,3J70C@40674|Mammalia,351Y5@311790|Afrotheria 33208|Metazoa S Phospholipase D NAPEPLD GO:0001523,GO:0001659,GO:0001750,GO:0003674,GO:0003824,GO:0004620,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005929,GO:0006066,GO:0006576,GO:0006629,GO:0006644,GO:0006650,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007568,GO:0008081,GO:0008150,GO:0008152,GO:0008270,GO:0009308,GO:0009987,GO:0012505,GO:0016020,GO:0016101,GO:0016298,GO:0016787,GO:0016788,GO:0019637,GO:0031090,GO:0031253,GO:0031347,GO:0031349,GO:0031410,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0031982,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0034308,GO:0034641,GO:0035900,GO:0036477,GO:0042439,GO:0042578,GO:0042592,GO:0042622,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045595,GO:0045597,GO:0045598,GO:0045600,GO:0046337,GO:0046486,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048521,GO:0048522,GO:0048583,GO:0048584,GO:0048871,GO:0050727,GO:0050729,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050896,GO:0051094,GO:0060170,GO:0060259,GO:0065007,GO:0065008,GO:0070013,GO:0070290,GO:0070291,GO:0070292,GO:0071704,GO:0071944,GO:0080134,GO:0090335,GO:0090336,GO:0097458,GO:0097708,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098590,GO:0120025,GO:0120038,GO:1901564,GO:1901615,GO:1903998,GO:1903999,GO:2000252 3.1.4.54 ko:K13985 ko04723,map04723 - - - ko00000,ko00001,ko01000 - - - Lactamase_B_2 GNS1_k127_5658254_19 42256.RradSPS_1018 1.476e-08 57.0 COG3639@1|root,COG3639@2|Bacteria,2IAPI@201174|Actinobacteria 201174|Actinobacteria P ABC-type phosphate phosphonate transport system permease component - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 GNS1_k127_5658254_15 886379.AEWI01000013_gene2105 8.442e-22 98.0 COG2337@1|root,COG2337@2|Bacteria,4NRIX@976|Bacteroidetes 976|Bacteroidetes L Toxic component of a toxin-antitoxin (TA) module - - - ko:K07171 - - - - ko00000,ko01000,ko02048 - - - PemK_toxin GNS1_k127_5658254_7 671143.DAMO_1885 2.826e-122 398.0 COG3639@1|root,COG3639@2|Bacteria,2NPPG@2323|unclassified Bacteria 2|Bacteria U Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.6.1.63 ko:K02042,ko:K06162 ko00440,ko02010,map00440,map02010 M00223 R10186 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - BPD_transp_1 GNS1_k127_5658254_4 671143.DAMO_1884 1.605e-151 482.0 COG3639@1|root,COG3639@2|Bacteria,2NPPG@2323|unclassified Bacteria 2|Bacteria U Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology phnE - 3.6.1.63 ko:K02042,ko:K06162 ko00440,ko02010,map00440,map02010 M00223 R10186 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - BPD_transp_1 GNS1_k127_5658254_11 118168.MC7420_3944 2.396e-71 250.0 COG3638@1|root,COG3638@2|Bacteria,1G21W@1117|Cyanobacteria,1H9MW@1150|Oscillatoriales 1117|Cyanobacteria P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran GNS1_k127_5658254_6 671143.DAMO_1882 3.639e-146 468.0 COG3221@1|root,COG3221@2|Bacteria,2NRED@2323|unclassified Bacteria 2|Bacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein phnD - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd GNS1_k127_5658254_14 1185876.BN8_02144 4.109e-42 169.0 COG1305@1|root,COG1305@2|Bacteria,4NIH4@976|Bacteroidetes,47MIE@768503|Cytophagia 976|Bacteroidetes E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core GNS1_k127_5658254_17 526222.Desal_1052 6.654e-11 66.0 COG0607@1|root,COG0607@2|Bacteria,1Q04H@1224|Proteobacteria,436CR@68525|delta/epsilon subdivisions,2X0XU@28221|Deltaproteobacteria,2MDQU@213115|Desulfovibrionales 28221|Deltaproteobacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - GNS1_k127_5658254_8 891968.Anamo_1144 6.332e-119 396.0 COG1029@1|root,COG1029@2|Bacteria,3TBWP@508458|Synergistetes 508458|Synergistetes C Molybdopterin oxidoreductase - - 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Molybdopterin GNS1_k127_5658254_0 330214.NIDE0577 0.0 1104.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - DUF853,DUF87 GNS1_k127_5658254_10 671143.DAMO_1169 2.903e-83 290.0 2C8XG@1|root,2Z7PK@2|Bacteria,2NR2W@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 GNS1_k127_5658254_12 671143.DAMO_1170 2.578e-64 224.0 COG1970@1|root,COG1970@2|Bacteria,2NPH6@2323|unclassified Bacteria 2|Bacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL GNS1_k127_5658254_5 671143.DAMO_0804 1.908e-150 482.0 COG0583@1|root,COG0583@2|Bacteria,2NPS6@2323|unclassified Bacteria 2|Bacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate GNS1_k127_5658254_3 671143.DAMO_0805 3.01e-162 520.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 GNS1_k127_5658254_2 671143.DAMO_0806 4.077e-204 655.0 COG2982@1|root,COG2982@2|Bacteria 2|Bacteria M Protein involved in outer membrane biogenesis asmA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - ko:K07289,ko:K07290 - - - - ko00000 9.B.121 - - AsmA,AsmA_2 GNS1_k127_5658254_1 671143.DAMO_0807 9.745e-247 770.0 COG0064@1|root,COG0064@2|Bacteria,2NNPK@2323|unclassified Bacteria 2|Bacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GatB_N,GatB_Yqey GNS1_k127_5658254_13 671143.DAMO_0808 2.729e-61 213.0 COG3703@1|root,COG3703@2|Bacteria 2|Bacteria P gamma-glutamylcyclotransferase activity ykqA - - - - - - - - - - - AIG2_2,GGACT GNS1_k127_5664152_1 671143.DAMO_2296 1.001e-204 643.0 COG0773@1|root,COG0773@2|Bacteria,2NNPU@2323|unclassified Bacteria 2|Bacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093,iJN678.murC Mur_ligase,Mur_ligase_C,Mur_ligase_M GNS1_k127_5664152_3 671143.DAMO_2295 2.163e-139 456.0 COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria 2|Bacteria M Cell wall formation murB GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.98,6.3.2.4 ko:K00075,ko:K01921 ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502 - R01150,R03191,R03192 RC00064,RC00141,RC02639 ko00000,ko00001,ko01000,ko01011 - - iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iIT341.HP1418,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845,iYO844.BSU15230 FAD_binding_4,MurB_C GNS1_k127_5664152_7 671143.DAMO_2294 1.311e-78 272.0 COG1589@1|root,COG1589@2|Bacteria,2NQ2T@2323|unclassified Bacteria 2|Bacteria D Essential cell division protein ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 - - - FtsQ,POTRA_1 GNS1_k127_5664152_0 671143.DAMO_2293 2.507e-216 676.0 COG0849@1|root,COG0849@2|Bacteria,2NNU2@2323|unclassified Bacteria 2|Bacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA GNS1_k127_5664152_2 671143.DAMO_2292 1.652e-190 601.0 COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria 2|Bacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin GNS1_k127_5664152_6 671143.DAMO_2290 6.242e-93 310.0 COG0325@1|root,COG0325@2|Bacteria,2NPEW@2323|unclassified Bacteria 2|Bacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - ko:K06997 - - - - ko00000 - - - Ala_racemase_N GNS1_k127_5664152_4 671143.DAMO_2288 7.233e-123 401.0 COG1414@1|root,COG1414@2|Bacteria,2NR17@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix isocitrate lyase regulation - - - - - - - - - - - - HTH_IclR,IclR GNS1_k127_5664152_5 1121468.AUBR01000012_gene2599 3.318e-108 361.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia 186801|Clostridia C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 GNS1_k127_5674622_1 1123060.JONP01000004_gene704 6.013e-57 203.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,2JW2Q@204441|Rhodospirillales 204441|Rhodospirillales C ATP ADP translocase - - - - - - - - - - - - MFS_1 GNS1_k127_5674622_0 1123060.JONP01000004_gene705 1.038e-105 352.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,2JQ9I@204441|Rhodospirillales 204441|Rhodospirillales S COG0656 Aldo keto reductases, related to diketogulonate reductase - - - - - - - - - - - - Aldo_ket_red GNS1_k127_5674622_2 861299.J421_4103 3.79e-12 72.0 COG0515@1|root,COG5184@1|root,COG0515@2|Bacteria,COG5184@2|Bacteria,1ZUHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes DKLTZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Pkinase,RCC1 GNS1_k127_5726338_10 1460634.JCM19037_3121 3.382e-10 61.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli 91061|Bacilli IQ reductase fabG GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - iYO844.BSU15910 adh_short_C2 GNS1_k127_5726338_2 671143.DAMO_2568 5.097e-151 478.0 COG1432@1|root,COG1432@2|Bacteria,2NQWI@2323|unclassified Bacteria 2|Bacteria S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH GNS1_k127_5726338_0 671143.DAMO_2569 5.085e-200 629.0 COG0530@1|root,COG0530@2|Bacteria,2NPSH@2323|unclassified Bacteria 2|Bacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex GNS1_k127_5726338_5 671143.DAMO_2570 1.061e-84 288.0 COG0398@1|root,COG0398@2|Bacteria,2NRVF@2323|unclassified Bacteria 2|Bacteria S SNARE associated Golgi protein yjbF - - - - - - - - - - - SNARE_assoc GNS1_k127_5726338_11 1217718.ALOU01000004_gene4622 0.0003634 47.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA GNS1_k127_5726338_8 671143.DAMO_2572 3.228e-38 145.0 COG2331@1|root,COG2331@2|Bacteria,2NQ36@2323|unclassified Bacteria 2|Bacteria S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 GNS1_k127_5726338_6 429009.Adeg_1465 7.133e-42 162.0 COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24JDV@186801|Clostridia,42G0T@68295|Thermoanaerobacterales 186801|Clostridia G PFAM Phosphoglycerate mutase pspA - 3.1.3.3,3.1.3.73 ko:K02226,ko:K22305 ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130 M00122 R00582,R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 GNS1_k127_5726338_3 671143.DAMO_2574 8.551e-121 394.0 COG1427@1|root,COG1427@2|Bacteria,2NRPR@2323|unclassified Bacteria 2|Bacteria S Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 1.21.98.1,4.2.1.151 ko:K07081,ko:K11782,ko:K11784 ko00130,ko01110,map00130,map01110 - R08588,R10666 RC02329,RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth GNS1_k127_5726338_1 671143.DAMO_2575 3.271e-186 591.0 COG0402@1|root,COG0402@2|Bacteria,2NNT7@2323|unclassified Bacteria 2|Bacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine ssnA - 3.5.4.40 ko:K20810 ko00130,ko01110,map00130,map01110 - R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 GNS1_k127_5726338_4 671143.DAMO_2576 5.836e-89 301.0 COG0746@1|root,COG0746@2|Bacteria,2NPYD@2323|unclassified Bacteria 2|Bacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - MobB,NTP_transf_3 GNS1_k127_5726338_7 671143.DAMO_2577 2.074e-38 150.0 COG1758@1|root,COG1758@2|Bacteria 2|Bacteria K DNA-directed 5'-3' RNA polymerase activity rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 GNS1_k127_5726338_9 671143.DAMO_2578 7.409e-38 143.0 COG0194@1|root,COG0194@2|Bacteria,2NPIN@2323|unclassified Bacteria 2|Bacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin GNS1_k127_5729500_7 671143.DAMO_3057 7.756e-18 91.0 COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria 2|Bacteria M OmpA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA GNS1_k127_5729500_5 671143.DAMO_1223 2.638e-72 246.0 COG2193@1|root,COG2193@2|Bacteria,2NR6S@2323|unclassified Bacteria 2|Bacteria P Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex bfr GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin GNS1_k127_5729500_2 1121468.AUBR01000090_gene747 1.188e-121 402.0 COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24AD9@186801|Clostridia 186801|Clostridia I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt GNS1_k127_5729500_4 1120973.AQXL01000133_gene1707 3.084e-97 337.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1UDNN@1239|Firmicutes 1239|Firmicutes I 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - ACP_syn_III_C,DUF35_N,OB_aCoA_assoc GNS1_k127_5729500_1 671143.DAMO_1224 8.868e-264 823.0 COG0457@1|root,COG0457@2|Bacteria 671143.DAMO_1224|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GNS1_k127_5729500_8 324602.Caur_1871 3.544e-17 83.0 COG1977@1|root,COG1977@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process moaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.77,2.8.1.12,4.6.1.17 ko:K03636,ko:K03637,ko:K03752,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395,R11372,R11581 RC02507,RC03425 ko00000,ko00001,ko01000 - - iE2348C_1286.E2348C_0736,iEC55989_1330.EC55989_0827,iG2583_1286.G2583_1012,iLF82_1304.LF82_1368,iNRG857_1313.NRG857_03495,iSFV_1184.SFV_0767,iSF_1195.SF0734,iSFxv_1172.SFxv_0800,iSSON_1240.SSON_0763,iS_1188.S0775 ThiS GNS1_k127_5729500_6 671143.DAMO_1226 2.701e-72 245.0 COG0314@1|root,COG0314@2|Bacteria,2NR4E@2323|unclassified Bacteria 2|Bacteria H MoaE protein moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 ko:K03635,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS GNS1_k127_5729500_0 671143.DAMO_1227 6.867e-304 944.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase fadE - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GNS1_k127_5729500_3 671143.DAMO_1228 2.493e-105 344.0 COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria 2|Bacteria I Belongs to the thiolase family fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N GNS1_k127_5761278_8 330214.NIDE1288 3.448e-05 53.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,HEAT_PBS,Metallophos,NACHT,Trypsin_2 GNS1_k127_5761278_7 1121377.KB906401_gene3474 7.864e-31 136.0 COG1649@1|root,COG1649@2|Bacteria 2|Bacteria F PFAM Uncharacterised BCR, COG1649 - - - - - - - - - - - - CarboxypepD_reg,GHL10 GNS1_k127_5761278_0 671143.DAMO_1073 0.0 1470.0 COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria 2|Bacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N GNS1_k127_5761278_1 1449126.JQKL01000016_gene2873 1.983e-149 483.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia 186801|Clostridia C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 GNS1_k127_5761278_5 671143.DAMO_0015 2.284e-44 164.0 COG4768@1|root,COG4768@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF948) WQ51_05790 - - - - - - - - - - - DUF948 GNS1_k127_5761278_6 671143.DAMO_0014 1.41e-38 151.0 COG4980@1|root,COG4980@2|Bacteria 2|Bacteria D gas vesicle protein XK27_07760 - - - - - - - - - - - YtxH GNS1_k127_5761278_2 671143.DAMO_0013 2.055e-137 443.0 COG0483@1|root,COG0483@2|Bacteria,2NQAS@2323|unclassified Bacteria 2|Bacteria G Inositol monophosphatase family hisN - 3.1.3.15,3.1.3.25 ko:K01092,ko:K05602 ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00131 R01185,R01186,R01187,R03013 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P GNS1_k127_5761278_3 1095769.CAHF01000021_gene938 5.29e-131 422.0 COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VNEK@28216|Betaproteobacteria,477GY@75682|Oxalobacteraceae 28216|Betaproteobacteria P ABC-type sugar transport system, permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 GNS1_k127_5761278_4 1366050.N234_01105 4.432e-92 304.0 COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VHA0@28216|Betaproteobacteria,1KHRY@119060|Burkholderiaceae 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K10237 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - BPD_transp_1 GNS1_k127_5815018_14 331113.SNE_A00400 4.458e-06 57.0 COG1752@1|root,COG1752@2|Bacteria,2JFZH@204428|Chlamydiae 204428|Chlamydiae S Patatin-like phospholipase ylbK - - ko:K07001 - - - - ko00000 - - - Patatin GNS1_k127_5815018_9 671143.DAMO_2771 1.873e-24 111.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria 2|Bacteria M Transglycosylase SLT domain CP_0155 - - ko:K08307,ko:K12204 - - - - ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 - - LysM,SLT,T4SS_TraI GNS1_k127_5815018_2 671143.DAMO_2771 1.42e-153 497.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria 2|Bacteria M Transglycosylase SLT domain CP_0155 - - ko:K08307,ko:K12204 - - - - ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 - - LysM,SLT,T4SS_TraI GNS1_k127_5815018_12 641112.ACOK01000093_gene1100 3.954e-15 85.0 COG0500@1|root,COG2226@2|Bacteria,1UVT3@1239|Firmicutes,24G51@186801|Clostridia,3WGW5@541000|Ruminococcaceae 186801|Clostridia Q O-methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 GNS1_k127_5815018_13 391009.Tmel_1112 1.001e-10 72.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 GNS1_k127_5815018_1 671143.DAMO_1456 6.946e-176 564.0 COG1807@1|root,COG1807@2|Bacteria,2NRDV@2323|unclassified Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 GNS1_k127_5815018_8 113395.AXAI01000009_gene2366 7.04e-26 114.0 COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria,2U09H@28211|Alphaproteobacteria,3JQVX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Acetyltransferase (GNAT) domain MA20_16670 - - - - - - - - - - - Acetyltransf_1 GNS1_k127_5815018_0 330214.NIDE3314 4.567e-214 681.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - - - - - - - - - - AA_permease_2 GNS1_k127_5815018_4 671143.DAMO_2802 3.305e-67 230.0 COG0494@1|root,COG0494@2|Bacteria 2|Bacteria L nUDIX hydrolase mutT - 3.6.1.13,3.6.1.17,5.3.1.16 ko:K01515,ko:K01518,ko:K01814 ko00230,ko00240,ko00340,ko01100,ko01110,ko01230,map00230,map00240,map00340,map01100,map01110,map01230 M00026 R00184,R00969,R01054,R01232,R02805,R04640 RC00002,RC00945 ko00000,ko00001,ko00002,ko01000 - - - NUDIX GNS1_k127_5815018_6 709986.Deima_1705 6.742e-48 182.0 COG4221@1|root,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity - - - - - - - - - - - - adh_short GNS1_k127_5815018_3 926550.CLDAP_33840 8.187e-137 442.0 COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi 200795|Chloroflexi C Radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM GNS1_k127_5815018_7 530564.Psta_3892 3.797e-28 117.0 COG1917@1|root,COG1917@2|Bacteria,2J134@203682|Planctomycetes 203682|Planctomycetes S PFAM Cupin 2 conserved barrel domain protein - - - - - - - - - - - - Cupin_2 GNS1_k127_5815018_11 671143.DAMO_2798 9.367e-16 78.0 COG1977@1|root,COG1977@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process - - 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - ThiS GNS1_k127_5821003_0 671143.DAMO_1877 1.379e-273 853.0 COG5000@1|root,COG5000@2|Bacteria,2NQZA@2323|unclassified Bacteria 2|Bacteria T Multi-sensor signal transduction histidine kinase ntrB - 2.7.13.3 ko:K07710 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8 GNS1_k127_5821003_1 671143.DAMO_1876 7.391e-227 715.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system nla6 - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_5821003_8 671143.DAMO_1874 9.103e-28 117.0 COG1622@1|root,COG1622@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1 GNS1_k127_5821003_5 404589.Anae109_3113 8.092e-55 198.0 COG1942@1|root,COG1942@2|Bacteria,1RHA5@1224|Proteobacteria,431G6@68525|delta/epsilon subdivisions,2WWH2@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tautomerase enzyme - - - - - - - - - - - - Tautomerase_2 GNS1_k127_5821003_4 485913.Krac_9606 3.757e-142 464.0 COG2267@1|root,COG2267@2|Bacteria,2G8RT@200795|Chloroflexi 200795|Chloroflexi I Alpha/beta hydrolase family - - - ko:K22318 - - - - ko00000 - - - Abhydrolase_1 GNS1_k127_5821003_6 395493.BegalDRAFT_1907 3.667e-45 168.0 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity MA20_08885 - - ko:K17362 - - - - ko00000,ko01000,ko01004 - - - 4HBT GNS1_k127_5821003_7 443143.GM18_0877 8.665e-42 163.0 COG0500@1|root,COG2226@2|Bacteria,1QYSR@1224|Proteobacteria 1224|Proteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_23,Methyltransf_25 GNS1_k127_5821003_2 671143.DAMO_0702 2.233e-179 565.0 COG3424@1|root,COG3424@2|Bacteria,2NPHJ@2323|unclassified Bacteria 2|Bacteria Q Chalcone and stilbene synthases, C-terminal domain bcsA GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.246 ko:K16424 ko01055,ko01130,map01055,map01130 - R06625 RC00004,RC02933 ko00000,ko00001,ko01000 - - - ACP_syn_III_C,Chal_sti_synt_C,Chal_sti_synt_N,FAE1_CUT1_RppA GNS1_k127_5821003_3 671143.DAMO_0704 1.961e-158 505.0 COG0404@1|root,COG0404@2|Bacteria,2NNSR@2323|unclassified Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C GNS1_k127_5829193_2 671143.DAMO_2145 1.132e-124 413.0 COG0115@1|root,COG0115@2|Bacteria,2NPXA@2323|unclassified Bacteria 2|Bacteria H Amino-transferase class IV - - 2.6.1.21,2.6.1.42 ko:K00824,ko:K00826 ko00270,ko00280,ko00290,ko00310,ko00330,ko00360,ko00472,ko00473,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01148,R01214,R01582,R02199,R02459,R02851,R02924,R05053,R10991 RC00006,RC00008,RC00025,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 GNS1_k127_5829193_0 671143.DAMO_2144 6.655e-248 772.0 COG0147@1|root,COG0147@2|Bacteria,2NP4C@2323|unclassified Bacteria 2|Bacteria EH chorismate binding enzyme pabB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01657,ko:K01665,ko:K03342,ko:K13503,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEC042_1314.EC042_1977 Aminotran_4,Anth_synt_I_N,Chorismate_bind,GATase GNS1_k127_5829193_1 671143.DAMO_2143 4.861e-126 414.0 COG0543@1|root,COG0543@2|Bacteria,2NPJH@2323|unclassified Bacteria 2|Bacteria CH Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B pyrK - 1.18.1.2,1.19.1.1 ko:K00528,ko:K02823 ko00240,ko01100,map00240,map01100 - R10159 - ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 GNS1_k127_5829193_3 671143.DAMO_2142 8.419e-76 257.0 COG0458@1|root,COG0458@2|Bacteria,2NNPB@2323|unclassified Bacteria 2|Bacteria EF Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS GNS1_k127_5838642_7 671143.DAMO_0983 1.365e-54 197.0 COG0589@1|root,COG0589@2|Bacteria,2NPUM@2323|unclassified Bacteria 2|Bacteria T Universal stress protein family - - - - - - - - - - - - Usp GNS1_k127_5838642_2 671143.DAMO_0984 1.862e-178 568.0 COG3173@1|root,COG3173@2|Bacteria 2|Bacteria S very-long-chain-acyl-CoA dehydrogenase activity - - - - - - - - - - - - APH GNS1_k127_5838642_4 671143.DAMO_0985 6.951e-81 274.0 COG0529@1|root,COG0529@2|Bacteria 2|Bacteria P adenylylsulfate kinase activity cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase GNS1_k127_5838642_9 643648.Slip_2357 2.187e-47 178.0 COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,42JYZ@68298|Syntrophomonadaceae 186801|Clostridia S PFAM CBS domain containing protein acuB - - ko:K04767 - - - - ko00000 - - - ACT,CBS GNS1_k127_5838642_8 671143.DAMO_0994 7.245e-48 179.0 COG1247@1|root,COG1247@2|Bacteria 2|Bacteria M phosphinothricin N-acetyltransferase activity MA20_16670 - - - - - - - - - - - Acetyltransf_1 GNS1_k127_5838642_6 671143.DAMO_0994 2.068e-55 200.0 COG1247@1|root,COG1247@2|Bacteria 2|Bacteria M phosphinothricin N-acetyltransferase activity MA20_16670 - - - - - - - - - - - Acetyltransf_1 GNS1_k127_5838642_3 671143.DAMO_0988 1.354e-82 276.0 COG1499@1|root,COG1499@2|Bacteria,2NS26@2323|unclassified Bacteria 2|Bacteria J ribosomal large subunit export from nucleus - - - - - - - - - - - - NMD3 GNS1_k127_5838642_1 671143.DAMO_0989 2.839e-205 644.0 COG1812@1|root,COG1812@2|Bacteria 2|Bacteria E S-adenosylmethionine synthetase (AdoMet synthetase) metK-2 - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase GNS1_k127_5838642_5 671143.DAMO_0990 8.013e-75 256.0 COG0517@1|root,COG0517@2|Bacteria,2NRG1@2323|unclassified Bacteria 2|Bacteria S Domain in cystathionine beta-synthase and other proteins. acuB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - ko:K04767 - - - - ko00000 - - - ACT,CBS GNS1_k127_5838642_14 671143.DAMO_0990 3.577e-10 60.0 COG0517@1|root,COG0517@2|Bacteria,2NRG1@2323|unclassified Bacteria 2|Bacteria S Domain in cystathionine beta-synthase and other proteins. acuB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - ko:K04767 - - - - ko00000 - - - ACT,CBS GNS1_k127_5838642_0 671143.DAMO_0992 0.0 1382.0 COG0474@1|root,COG0474@2|Bacteria,2NQM6@2323|unclassified Bacteria 2|Bacteria P Cation transporter/ATPase, N-terminus pacL - 3.6.3.8,3.6.3.9 ko:K01537,ko:K01539 ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 - - - ko00000,ko00001,ko01000,ko04147 3.A.3.1,3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 GNS1_k127_5838642_11 404589.Anae109_0806 4.558e-25 110.0 COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2Z1J6@29|Myxococcales 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp GNS1_k127_5838642_10 671143.DAMO_0994 1.118e-43 166.0 COG1247@1|root,COG1247@2|Bacteria 2|Bacteria M phosphinothricin N-acetyltransferase activity MA20_16670 - - - - - - - - - - - Acetyltransf_1 GNS1_k127_5865404_3 671143.DAMO_2296 6.541e-52 184.0 COG0773@1|root,COG0773@2|Bacteria,2NNPU@2323|unclassified Bacteria 2|Bacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093,iJN678.murC Mur_ligase,Mur_ligase_C,Mur_ligase_M GNS1_k127_5865404_0 671143.DAMO_2297 1.104e-165 531.0 COG0707@1|root,COG0707@2|Bacteria,2NP4Z@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Glyco_tran_28_C,Glyco_transf_28 GNS1_k127_5865404_1 671143.DAMO_2298 8.76e-148 478.0 COG0772@1|root,COG0772@2|Bacteria,2NP3P@2323|unclassified Bacteria 2|Bacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE GNS1_k127_5865404_2 671143.DAMO_2299 1.638e-101 335.0 COG0771@1|root,COG0771@2|Bacteria,2NP27@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M GNS1_k127_5905439_4 671143.DAMO_1271 6.974e-45 167.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_C554 GNS1_k127_5905439_5 671143.DAMO_2211 1.838e-42 160.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 GNS1_k127_5905439_1 485913.Krac_7973 1.445e-69 244.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_5905439_3 552811.Dehly_0347 1.261e-56 210.0 COG0702@1|root,COG0702@2|Bacteria,2G6I7@200795|Chloroflexi,34CR0@301297|Dehalococcoidia 301297|Dehalococcoidia M NmrA-like family - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 GNS1_k127_5905439_6 671143.DAMO_1268 4.474e-18 85.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 GNS1_k127_5905439_8 1121406.JAEX01000012_gene626 0.0005146 47.0 2ECCP@1|root,336AZ@2|Bacteria,1N9PN@1224|Proteobacteria,42W93@68525|delta/epsilon subdivisions,2WRXB@28221|Deltaproteobacteria,2MCH8@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Rho_N GNS1_k127_5905439_0 443143.GM18_4008 5.222e-98 337.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42R7Z@68525|delta/epsilon subdivisions,2WN0B@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM ATP-binding region, ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg GNS1_k127_5905439_2 671143.DAMO_1263 3.197e-67 229.0 COG0780@1|root,COG0780@2|Bacteria,2NPZV@2323|unclassified Bacteria 2|Bacteria S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF GNS1_k127_5905439_7 1121405.dsmv_1356 4.47e-12 67.0 COG3357@1|root,COG3357@2|Bacteria,1N7JG@1224|Proteobacteria,42VEP@68525|delta/epsilon subdivisions,2WRD7@28221|Deltaproteobacteria,2MM4Q@213118|Desulfobacterales 28221|Deltaproteobacteria K transcriptional regulator containing an HTH domain fused to a Zn-ribbon - - - ko:K07743 - - - - ko00000 - - - HTH_5 GNS1_k127_6038355_6 671143.DAMO_0058 6.765e-83 282.0 COG1686@1|root,COG1686@2|Bacteria,2NPJT@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S11 family dacA - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11 GNS1_k127_6038355_5 671143.DAMO_0057 8.715e-89 296.0 COG0279@1|root,COG0279@2|Bacteria,2NPPB@2323|unclassified Bacteria 2|Bacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HupF_HypC,SIS_2 GNS1_k127_6038355_3 671143.DAMO_0056 3.156e-156 497.0 COG0341@1|root,COG0341@2|Bacteria,2NP4P@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG GNS1_k127_6038355_1 671143.DAMO_0055 4.253e-254 792.0 COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG GNS1_k127_6038355_0 671143.DAMO_0054 8.704e-262 812.0 COG1982@1|root,COG1982@2|Bacteria,2NNUZ@2323|unclassified Bacteria 2|Bacteria E Orn/Lys/Arg decarboxylase, C-terminal domain speA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564 4.1.1.18,4.1.1.19 ko:K01582,ko:K01585 ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110 M00133 R00462,R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C GNS1_k127_6038355_2 671143.DAMO_0053 2.687e-174 551.0 COG0421@1|root,COG0421@2|Bacteria,2NPMY@2323|unclassified Bacteria 2|Bacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth GNS1_k127_6038355_7 1123376.AUIU01000013_gene1779 1.961e-53 194.0 COG1586@1|root,COG1586@2|Bacteria,3J15H@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc GNS1_k127_6038355_4 671143.DAMO_0051 2.098e-99 330.0 COG0399@1|root,COG0399@2|Bacteria,2NNS2@2323|unclassified Bacteria 2|Bacteria E Belongs to the DegT DnrJ EryC1 family degT - - - - - - - - - - - DegT_DnrJ_EryC1 GNS1_k127_6038355_9 671143.DAMO_0051 1.106e-09 61.0 COG0399@1|root,COG0399@2|Bacteria,2NNS2@2323|unclassified Bacteria 2|Bacteria E Belongs to the DegT DnrJ EryC1 family degT - - - - - - - - - - - DegT_DnrJ_EryC1 GNS1_k127_6038355_8 497964.CfE428DRAFT_2169 8.344e-12 67.0 COG0399@1|root,COG0399@2|Bacteria,46SEI@74201|Verrucomicrobia 74201|Verrucomicrobia E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 GNS1_k127_6071253_3 671143.DAMO_1128 5.359e-08 57.0 COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain phoR - 2.7.13.3 ko:K02484,ko:K07636,ko:K07768 ko02020,map02020 M00434,M00443 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like GNS1_k127_6071253_0 671143.DAMO_1129 6.764e-123 397.0 COG0745@1|root,COG0745@2|Bacteria,2NPCK@2323|unclassified Bacteria 2|Bacteria T Two component transcriptional regulator, winged helix family - - - ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C GNS1_k127_6071253_2 670307.HYPDE_27163 2.158e-13 74.0 COG3474@1|root,COG3474@2|Bacteria,1R7NI@1224|Proteobacteria,2U1TH@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C GNS1_k127_6071253_1 671143.DAMO_1130 4.846e-42 156.0 COG2005@1|root,COG2005@2|Bacteria,2NRCV@2323|unclassified Bacteria 2|Bacteria S Bacterial regulatory helix-turn-helix protein, lysR family modE GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 - ko:K02019,ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000,ko03000 3.A.1.6.2,3.A.1.6.4 - - HTH_1,TOBE GNS1_k127_6071253_4 671143.DAMO_1131 2.003e-05 53.0 COG3585@1|root,COG3585@2|Bacteria 2|Bacteria H molybdate ion transport modE GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE GNS1_k127_6353337_5 443143.GM18_4514 3.825e-11 64.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2WJKT@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N GNS1_k127_6353337_2 671143.DAMO_2316 1.787e-162 520.0 COG0329@1|root,COG0329@2|Bacteria,2NP5Q@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS GNS1_k127_6353337_4 671143.DAMO_2317 9.049e-132 426.0 COG0253@1|root,COG0253@2|Bacteria,2NPFA@2323|unclassified Bacteria 2|Bacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0566,iLJ478.TM1522 DAP_epimerase GNS1_k127_6353337_1 671143.DAMO_2318 1.278e-232 723.0 COG0019@1|root,COG0019@2|Bacteria,2NNQK@2323|unclassified Bacteria 2|Bacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.1.129,3.4.16.4,4.1.1.20 ko:K01586,ko:K05366 ko00300,ko00550,ko01100,ko01110,ko01120,ko01130,ko01230,ko01501,map00300,map00550,map01100,map01110,map01120,map01130,map01230,map01501 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000,ko01003,ko01011 - GT51 iLJ478.TM1517 Orn_Arg_deC_N,Orn_DAP_Arg_deC GNS1_k127_6353337_3 671143.DAMO_0087 6.138e-143 461.0 COG4733@1|root,COG4733@2|Bacteria,2NQ62@2323|unclassified Bacteria 2|Bacteria S Fibronectin type 3 domain - - - - - - - - - - - - PA14,fn3 GNS1_k127_6353337_0 671143.DAMO_0086 2.669e-237 740.0 COG0165@1|root,COG0165@2|Bacteria,2NP70@2323|unclassified Bacteria 2|Bacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K01755,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844,M00845 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 GNS1_k127_6368364_1 96561.Dole_3007 2.844e-89 303.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42QDN@68525|delta/epsilon subdivisions,2WKRW@28221|Deltaproteobacteria,2MMXT@213118|Desulfobacterales 28221|Deltaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran GNS1_k127_6368364_2 83219.PM02_12435 9.16e-85 289.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2V7DE@28211|Alphaproteobacteria,3ZZ1I@60136|Sulfitobacter 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C GNS1_k127_6368364_0 706587.Desti_4334 2.97e-91 314.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor - - - - - - - - - - - - Peripla_BP_6 GNS1_k127_6368364_3 644282.Deba_1711 1.112e-44 166.0 COG0559@1|root,COG0559@2|Bacteria,1MXGK@1224|Proteobacteria,42NUW@68525|delta/epsilon subdivisions,2WMC0@28221|Deltaproteobacteria 28221|Deltaproteobacteria U PFAM Branched-chain amino acid transport system permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 GNS1_k127_644029_11 338966.Ppro_0646 8.766e-15 85.0 COG0457@1|root,COG0457@2|Bacteria,1NSRW@1224|Proteobacteria,42YBG@68525|delta/epsilon subdivisions,2WTZ6@28221|Deltaproteobacteria,43TDF@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19 GNS1_k127_644029_5 671143.DAMO_1195 1.533e-91 305.0 COG0558@1|root,COG0558@2|Bacteria,2NPJ9@2323|unclassified Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iIT341.HP1016 CDP-OH_P_transf GNS1_k127_644029_6 671143.DAMO_1196 3.59e-79 270.0 COG0344@1|root,COG0344@2|Bacteria,2NPME@2323|unclassified Bacteria 2|Bacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15,2.7.9.2,3.5.1.104 ko:K01007,ko:K03977,ko:K08591,ko:K22278 ko00561,ko00564,ko00620,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,map00561,map00564,map00620,map00680,map00720,map01100,map01110,map01120,map01200 M00089,M00173,M00374 R00199,R00851,R09380 RC00002,RC00004,RC00015,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko03009 - - - G3P_acyltransf GNS1_k127_644029_0 671143.DAMO_1197 6.842e-208 653.0 COG0527@1|root,COG0527@2|Bacteria,2NNWK@2323|unclassified Bacteria 2|Bacteria E Evidence 2a Function of homologous gene experimentally demonstrated in an other organism lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 GNS1_k127_644029_8 671143.DAMO_1198 7.46e-36 142.0 COG1555@1|root,COG1555@2|Bacteria 2|Bacteria L photosystem II stabilization comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB GNS1_k127_644029_4 671143.DAMO_1199 1.686e-93 312.0 COG1354@1|root,COG1354@2|Bacteria,2NPM8@2323|unclassified Bacteria 2|Bacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA GNS1_k127_644029_7 316067.Geob_3014 6.867e-46 174.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,43US2@69541|Desulfuromonadales 28221|Deltaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB GNS1_k127_644029_3 671143.DAMO_1201 9.169e-106 349.0 COG1187@1|root,COG1187@2|Bacteria,2NPCM@2323|unclassified Bacteria 2|Bacteria J RNA pseudouridylate synthase rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 GNS1_k127_644029_2 671143.DAMO_1202 4.1e-186 586.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2NR2C@2323|unclassified Bacteria 2|Bacteria E Prephenate dehydratase pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,4.2.1.51,4.2.1.91,5.4.99.5 ko:K00661,ko:K01713,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715,R01728 RC00125,RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_2667 ACT,CM_2,PDT GNS1_k127_644029_1 671143.DAMO_1203 3.399e-190 599.0 COG0079@1|root,COG0079@2|Bacteria,2NNZK@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class I and II hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 GNS1_k127_644029_9 765912.Thimo_1662 4.325e-28 115.0 2C1SS@1|root,32YN6@2|Bacteria,1NNFV@1224|Proteobacteria,1SS40@1236|Gammaproteobacteria,1X173@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - GNS1_k127_644029_10 247490.KSU1_C0079 9.72e-17 81.0 2E90H@1|root,31X4M@2|Bacteria,2J4J2@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - GNS1_k127_6521529_1 671143.DAMO_2578 2.732e-46 168.0 COG0194@1|root,COG0194@2|Bacteria,2NPIN@2323|unclassified Bacteria 2|Bacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin GNS1_k127_6521529_2 671143.DAMO_2579 5.002e-40 150.0 COG2052@1|root,COG2052@2|Bacteria,2NRCM@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF370) ylzA - - ko:K09777 - - - - ko00000 - - - DUF370 GNS1_k127_6521529_0 671143.DAMO_2580 1.272e-122 401.0 COG1561@1|root,COG1561@2|Bacteria,2NPG5@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1732) yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N GNS1_k127_6521529_4 1157490.EL26_00230 6.355e-31 132.0 COG0454@1|root,COG0454@2|Bacteria,1TSEY@1239|Firmicutes,4HA1V@91061|Bacilli,279CI@186823|Alicyclobacillaceae 91061|Bacilli K Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue acuA GO:0001101,GO:0003674,GO:0003824,GO:0006066,GO:0006355,GO:0006950,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009056,GO:0009267,GO:0009605,GO:0009847,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010033,GO:0010034,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016407,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019152,GO:0019219,GO:0019222,GO:0019751,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032502,GO:0033554,GO:0034077,GO:0034078,GO:0034311,GO:0034313,GO:0042149,GO:0042180,GO:0042182,GO:0042221,GO:0042594,GO:0042844,GO:0042846,GO:0043894,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045013,GO:0045014,GO:0045149,GO:0045150,GO:0045892,GO:0045934,GO:0045990,GO:0046015,GO:0046164,GO:0046174,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0061984,GO:0061985,GO:0061986,GO:0065007,GO:0070887,GO:0071229,GO:0071236,GO:0071310,GO:0071311,GO:0071496,GO:0071704,GO:0080090,GO:1901575,GO:1901615,GO:1901616,GO:1901700,GO:1901701,GO:1902652,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K04766 - - - - ko00000,ko01000 - - - Acetyltransf_1 GNS1_k127_6521529_3 1101191.KI912577_gene3140 2.369e-38 145.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae 28211|Alphaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC GNS1_k127_6532839_3 671143.DAMO_1416 1.161e-43 162.0 COG0134@1|root,COG0134@2|Bacteria,2NPIH@2323|unclassified Bacteria 2|Bacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - - IGPS GNS1_k127_6532839_0 671143.DAMO_1417 5.681e-157 501.0 COG0547@1|root,COG0547@2|Bacteria,2NNVH@2323|unclassified Bacteria 2|Bacteria E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2495 GATase,Glycos_trans_3N,Glycos_transf_3 GNS1_k127_6532839_1 44251.PDUR_00340 2.128e-86 290.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli,26SGI@186822|Paenibacillaceae 91061|Bacilli EH with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine pabA - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase GNS1_k127_6532839_2 330214.NIDE2040 6.132e-70 239.0 COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae 40117|Nitrospirae EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind GNS1_k127_6599399_2 489825.LYNGBM3L_22570 1.246e-18 97.0 COG0392@1|root,COG0392@2|Bacteria,1G41A@1117|Cyanobacteria,1HD8Q@1150|Oscillatoriales 1117|Cyanobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GNS1_k127_6599399_0 382464.ABSI01000011_gene3125 1.809e-111 369.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 GNS1_k127_6599399_4 765420.OSCT_2445 2.563e-05 57.0 COG1807@1|root,COG1807@2|Bacteria,2GAB8@200795|Chloroflexi,374WB@32061|Chloroflexia 32061|Chloroflexia M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 GNS1_k127_6599399_1 1173027.Mic7113_0899 8.894e-101 343.0 COG3693@1|root,COG3693@2|Bacteria,1G30Y@1117|Cyanobacteria,1HEG8@1150|Oscillatoriales 1117|Cyanobacteria G PFAM Glycosyl hydrolase family 10 - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Glyco_hydro_10 GNS1_k127_6599399_3 1303518.CCALI_01381 2.515e-15 83.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 GNS1_k127_6654902_1 671143.DAMO_2986 7.755e-161 511.0 COG1494@1|root,COG1494@2|Bacteria,2NQE4@2323|unclassified Bacteria 2|Bacteria G Evidence 2b Function of strongly homologous gene glpX - 3.1.3.11,3.1.3.37 ko:K02446,ko:K11532 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX GNS1_k127_6654902_0 671143.DAMO_2987 1.016e-176 558.0 COG0124@1|root,COG0124@2|Bacteria,2NNZ7@2323|unclassified Bacteria 2|Bacteria J Histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His GNS1_k127_6707871_3 671143.DAMO_2693 6.915e-44 162.0 COG0713@1|root,COG0713@2|Bacteria,2NPU2@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 GNS1_k127_6707871_2 671143.DAMO_2694 1.445e-68 244.0 COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria 2|Bacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 GNS1_k127_6707871_1 671143.DAMO_2695 1.577e-182 574.0 COG1005@1|root,COG1005@2|Bacteria,2NNTT@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh GNS1_k127_6707871_0 671143.DAMO_2696 3.437e-240 748.0 COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB GNS1_k127_6766686_0 1283300.ATXB01000001_gene44 1.219e-147 475.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XDSC@135618|Methylococcales 135618|Methylococcales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran GNS1_k127_6766686_1 671143.DAMO_0962 3.247e-121 407.0 COG0845@1|root,COG0845@2|Bacteria,2NP3Y@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cebB - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA GNS1_k127_6766686_2 1379698.RBG1_1C00001G0080 2.845e-09 59.0 COG1538@1|root,COG1538@2|Bacteria,2NPI8@2323|unclassified Bacteria 2|Bacteria MU Outer membrane efflux protein cebC - - - - - - - - - - - OEP GNS1_k127_6771183_1 671143.DAMO_0392 5.076e-36 139.0 COG1734@1|root,COG1734@2|Bacteria 2|Bacteria T zinc ion binding dskA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR GNS1_k127_6771183_0 671143.DAMO_0393 0.0 1189.0 COG0507@1|root,COG0507@2|Bacteria,2NNQY@2323|unclassified Bacteria 2|Bacteria L Helix-hairpin-helix containing domain recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 GNS1_k127_6780510_1 671143.DAMO_2618 1.467e-173 552.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2NP0G@2323|unclassified Bacteria 2|Bacteria S Belongs to the CinA family cinA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth GNS1_k127_6780510_5 671143.DAMO_2617 2.411e-77 263.0 COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria 2|Bacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase GNS1_k127_6780510_2 1499967.BAYZ01000196_gene3073 2.394e-154 499.0 COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria 2|Bacteria G MOFRL family ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL GNS1_k127_6780510_0 671143.DAMO_3088 3.859e-219 687.0 COG0541@1|root,COG0541@2|Bacteria,2NNT9@2323|unclassified Bacteria 2|Bacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB GNS1_k127_6780510_9 671143.DAMO_3087 3.678e-43 158.0 COG0228@1|root,COG0228@2|Bacteria,2NPWN@2323|unclassified Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 GNS1_k127_6780510_10 671143.DAMO_3086 1.048e-37 145.0 COG1837@1|root,COG1837@2|Bacteria,2NPUP@2323|unclassified Bacteria 2|Bacteria S Belongs to the UPF0109 family CP_0960 GO:0008150,GO:0040007 - ko:K06960 - - - - ko00000 - - - KH_4 GNS1_k127_6780510_6 671143.DAMO_3085 1.072e-69 239.0 COG0806@1|root,COG0806@2|Bacteria,2NPUX@2323|unclassified Bacteria 2|Bacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM GNS1_k127_6780510_3 671143.DAMO_3084 3.263e-109 357.0 COG0336@1|root,COG0336@2|Bacteria,2NP5G@2323|unclassified Bacteria 2|Bacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 - - - tRNA_m1G_MT GNS1_k127_6780510_8 671143.DAMO_3083 2.261e-48 178.0 COG0335@1|root,COG0335@2|Bacteria,2NPKD@2323|unclassified Bacteria 2|Bacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 GNS1_k127_6780510_4 671143.DAMO_3082 3.238e-79 273.0 COG0164@1|root,COG0164@2|Bacteria,2NPD1@2323|unclassified Bacteria 2|Bacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII GNS1_k127_6780510_7 671143.DAMO_3081 2.917e-50 182.0 COG0792@1|root,COG0792@2|Bacteria,2NPW8@2323|unclassified Bacteria 2|Bacteria L Nuclease-related domain yraN - - ko:K07460 - - - - ko00000 - - - UPF0102 GNS1_k127_6780510_12 1128421.JAGA01000002_gene1500 1.457e-05 51.0 COG1146@1|root,COG1146@2|Bacteria,2NPWS@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain fdxA - - - - - - - - - - - Fer4,Fer4_4,Fer4_7 GNS1_k127_6780510_11 671143.DAMO_3080 3.035e-27 112.0 COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria 2|Bacteria O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C GNS1_k127_6789596_4 671143.DAMO_1630 1.302e-73 250.0 COG0151@1|root,COG0151@2|Bacteria,2NP0B@2323|unclassified Bacteria 2|Bacteria F Belongs to the GARS family purD - 6.3.2.6,6.3.4.13,6.3.5.3 ko:K01945,ko:K01952,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04463,R04591 RC00010,RC00064,RC00090,RC00162,RC00166,RC01160 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS05245,iYO844.BSU06530 GARS_A,GARS_C,GARS_N GNS1_k127_6789596_5 671143.DAMO_1631 3.968e-66 231.0 COG0041@1|root,COG0041@2|Bacteria,2NPN4@2323|unclassified Bacteria 2|Bacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18,6.3.4.13 ko:K01588,ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R07405 RC00090,RC00166,RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC GNS1_k127_6789596_2 671143.DAMO_1632 2.861e-103 355.0 COG1807@1|root,COG1807@2|Bacteria,2NPZC@2323|unclassified Bacteria 2|Bacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K00786 - - - - ko00000,ko01000 - - - PMT_2 GNS1_k127_6789596_3 671143.DAMO_1633 6.821e-93 325.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT,PMT_2 GNS1_k127_6789596_0 671143.DAMO_1634 2.264e-149 479.0 COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 arnC GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 GNS1_k127_6789596_1 671143.DAMO_1635 1.175e-128 419.0 COG0392@1|root,COG0392@2|Bacteria,2NPJC@2323|unclassified Bacteria 2|Bacteria S Lysylphosphatidylglycerol synthase TM region mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GNS1_k127_6789596_6 671143.DAMO_1636 1.87e-54 198.0 COG0671@1|root,COG0671@2|Bacteria,2NPZ6@2323|unclassified Bacteria 2|Bacteria I Phosphoesterase, PA-phosphatase related - - 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K19302 ko00550,ko00564,ko01100,map00550,map00564,map01100 - R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 - - - PAP2 GNS1_k127_6792911_0 671143.DAMO_2417 5.356e-252 795.0 COG0457@1|root,COG0741@1|root,COG1729@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,COG1729@2|Bacteria,2NPKN@2323|unclassified Bacteria 2|Bacteria M Transglycosylase SLT domain slt - - ko:K07114,ko:K08309 - - - - ko00000,ko01000,ko01011,ko02000 1.A.13.2.2,1.A.13.2.3 GH23 - SLT,TPR_16,TPR_6 GNS1_k127_6792911_1 671143.DAMO_2418 2.901e-99 329.0 COG0452@1|root,COG0452@2|Bacteria,2NNX9@2323|unclassified Bacteria 2|Bacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein GNS1_k127_6833806_0 1121468.AUBR01000069_gene1116 3.592e-289 922.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,42EQJ@68295|Thermoanaerobacterales 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF GNS1_k127_6833806_13 671143.DAMO_2535 1.066e-68 237.0 COG0615@1|root,COG0615@2|Bacteria,2NPMA@2323|unclassified Bacteria 2|Bacteria IM Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose aut - 2.7.1.167,2.7.7.70 ko:K03272,ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like GNS1_k127_6833806_12 671143.DAMO_2537 1.059e-72 255.0 COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria 2|Bacteria M OmpA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA GNS1_k127_6833806_21 533240.CRC_02125 5.932e-18 89.0 COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales 1117|Cyanobacteria O Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_8 GNS1_k127_6833806_2 530564.Psta_3290 6.308e-197 634.0 COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - DUF4139 GNS1_k127_6833806_14 1267535.KB906767_gene1576 1.83e-58 217.0 COG2010@1|root,COG2010@2|Bacteria,3Y7CN@57723|Acidobacteria,2JK7I@204432|Acidobacteriia 204432|Acidobacteriia C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 GNS1_k127_6833806_16 309801.trd_A0854 1.525e-56 204.0 COG1011@1|root,COG1011@2|Bacteria,2G7B3@200795|Chloroflexi,27YGG@189775|Thermomicrobia 189775|Thermomicrobia S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 GNS1_k127_6833806_15 1380394.JADL01000005_gene5569 3.433e-57 220.0 COG1276@1|root,COG1276@2|Bacteria,1MXRN@1224|Proteobacteria,2U272@28211|Alphaproteobacteria,2JQST@204441|Rhodospirillales 204441|Rhodospirillales P Copper resistance protein D - - - ko:K07245 - - - - ko00000,ko02000 9.B.62.1 - - CopD GNS1_k127_6833806_7 113355.CM001775_gene1136 7.842e-130 424.0 COG0535@1|root,COG0535@2|Bacteria,1G4VB@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Radical SAM - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM GNS1_k127_6833806_1 1382230.ASAP_0841 1.519e-200 634.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TRFJ@28211|Alphaproteobacteria,2JRB5@204441|Rhodospirillales 204441|Rhodospirillales C Radical SAM - - - - - - - - - - - - Radical_SAM GNS1_k127_6833806_4 671143.DAMO_2544 2.897e-182 586.0 COG0150@1|root,COG0150@2|Bacteria,2NNUJ@2323|unclassified Bacteria 2|Bacteria F AIR synthase related protein, N-terminal domain purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1844,iECSF_1327.ECSF_2340 AIRS,AIRS_C GNS1_k127_6833806_10 671143.DAMO_1141 1.164e-93 318.0 COG0725@1|root,COG0725@2|Bacteria,2NQT8@2323|unclassified Bacteria 2|Bacteria P Bacterial extracellular solute-binding protein modA GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704 - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 GNS1_k127_6833806_9 671143.DAMO_1142 9.144e-102 335.0 COG4149@1|root,COG4149@2|Bacteria 2|Bacteria P molybdate abc transporter modB - - ko:K02018,ko:K15496 ko02010,map02010 M00189,M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.5,3.A.1.8 - - BPD_transp_1 GNS1_k127_6833806_5 671143.DAMO_1143 2.573e-178 569.0 COG3842@1|root,COG3842@2|Bacteria 2|Bacteria P ATPase activity modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran GNS1_k127_6833806_8 671143.DAMO_1144 2.141e-113 370.0 COG4662@1|root,COG4662@2|Bacteria,2NPF5@2323|unclassified Bacteria 2|Bacteria H Binding-protein-dependent transport system inner membrane component tupB - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 GNS1_k127_6833806_6 671143.DAMO_1145 3.416e-168 536.0 COG3842@1|root,COG3842@2|Bacteria,2NNPE@2323|unclassified Bacteria 2|Bacteria E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system gtsA - 3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55 ko:K02010,ko:K02045,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112,ko:K11072 ko00920,ko02010,map00920,map02010 M00185,M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00299,M00491,M00602,M00605,M00606 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.10,3.A.1.11.1,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.1,3.A.1.6.2,3.A.1.6.3,3.A.1.6.4 - - ABC_tran,TOBE_2 GNS1_k127_6833806_11 671143.DAMO_1147 7.494e-80 271.0 COG0315@1|root,COG0315@2|Bacteria,2NPNE@2323|unclassified Bacteria 2|Bacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC GNS1_k127_6833806_3 671143.DAMO_1148 1.595e-191 602.0 COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria 2|Bacteria BQ Histone deacetylase domain acuC - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl GNS1_k127_6833806_17 671143.DAMO_1149 1.59e-50 181.0 COG1278@1|root,COG1278@2|Bacteria,2NPTN@2323|unclassified Bacteria 2|Bacteria K Probable zinc-ribbon domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD,Ribosomal_S30AE,zf-trcl GNS1_k127_6833806_22 671143.DAMO_1155 5.923e-08 55.0 COG1921@1|root,COG1921@2|Bacteria,2NNT6@2323|unclassified Bacteria 2|Bacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006 Se-cys_synth_N,SelA GNS1_k127_6858801_2 671143.DAMO_0459 5.765e-113 368.0 COG2037@1|root,COG2037@2|Bacteria 2|Bacteria H Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) ffsA GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0043446,GO:0044237,GO:0044281,GO:0071704 2.3.1.101 ko:K00672 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03390 RC00197,RC00870,RC02881 ko00000,ko00001,ko00002,ko01000 - - - FTR,FTR_C GNS1_k127_6858801_0 671143.DAMO_0458 1.022e-319 984.0 COG1229@1|root,COG1229@2|Bacteria 2|Bacteria C Formylmethanofuran dehydrogenase subunit A fhcA GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281 1.2.7.12 ko:K00200 ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 GNS1_k127_6858801_1 671143.DAMO_0457 2.734e-235 735.0 COG1029@1|root,COG1029@2|Bacteria 2|Bacteria - - fhcB GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Molybdopterin GNS1_k127_6874733_2 671143.DAMO_1511 8.86e-54 190.0 COG2267@1|root,COG2267@2|Bacteria,2NRVV@2323|unclassified Bacteria 2|Bacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 GNS1_k127_6874733_0 118163.Ple7327_0161 1.134e-261 814.0 COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,3VIAJ@52604|Pleurocapsales 1117|Cyanobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.39,1.2.1.79,1.2.1.8 ko:K00130,ko:K00135,ko:K00146,ko:K22187 ko00040,ko00250,ko00260,ko00310,ko00350,ko00360,ko00643,ko00650,ko00760,ko01100,ko01120,map00040,map00250,map00260,map00310,map00350,map00360,map00643,map00650,map00760,map01100,map01120 M00027,M00555 R00713,R00714,R02401,R02536,R02565,R02566,R11768 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh GNS1_k127_6874733_1 671143.DAMO_1044 3.867e-148 473.0 COG0761@1|root,COG0761@2|Bacteria,2NP7K@2323|unclassified Bacteria 2|Bacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - iIT341.HP0400,iLJ478.TM1444 LYTB,S1 GNS1_k127_6874736_3 671143.DAMO_1044 2.139e-34 134.0 COG0761@1|root,COG0761@2|Bacteria,2NP7K@2323|unclassified Bacteria 2|Bacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - iIT341.HP0400,iLJ478.TM1444 LYTB,S1 GNS1_k127_6874736_2 880072.Desac_0251 7.119e-65 228.0 COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,42TPX@68525|delta/epsilon subdivisions,2WNCR@28221|Deltaproteobacteria,2MSFN@213462|Syntrophobacterales 28221|Deltaproteobacteria S DJ-1/PfpI family - - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI GNS1_k127_6874736_0 671143.DAMO_0482 3.944e-104 342.0 COG1011@1|root,COG1011@2|Bacteria,2NQ1K@2323|unclassified Bacteria 2|Bacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase,Hydrolase_like GNS1_k127_6874736_1 671143.DAMO_0611 1.879e-95 329.0 COG1216@1|root,COG1216@2|Bacteria,2NRAF@2323|unclassified Bacteria 2|Bacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - GT87 GNS1_k127_6874736_4 671143.DAMO_0620 9.116e-31 124.0 2EA1Q@1|root,33470@2|Bacteria 2|Bacteria - - - - 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxD GNS1_k127_6926209_0 671143.DAMO_1035 1.935e-177 557.0 COG2046@1|root,COG2046@2|Bacteria,2NNS5@2323|unclassified Bacteria 2|Bacteria P PUA-like domain sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 GNS1_k127_6926209_2 671143.DAMO_1036 1.599e-73 253.0 COG0607@1|root,COG0607@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - Rhodanese GNS1_k127_6926209_1 671143.DAMO_0410 1.468e-98 325.0 COG2060@1|root,COG2060@2|Bacteria,2NP13@2323|unclassified Bacteria 2|Bacteria P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane kdpA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 ko:K01546 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780,iYL1228.KPN_00717 KdpA GNS1_k127_6955724_0 671143.DAMO_1500 0.0 1373.0 COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria 2|Bacteria C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase GNS1_k127_6955724_2 243231.GSU0081 1.57e-17 85.0 2CDR8@1|root,32ZSF@2|Bacteria,1NCBG@1224|Proteobacteria,42V4S@68525|delta/epsilon subdivisions,2WSDP@28221|Deltaproteobacteria,43VIE@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - GNS1_k127_6955724_1 671143.DAMO_1501 4.499e-246 764.0 COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria 2|Bacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iSB619.SA_RS05225 GATase_6,GATase_7,Pribosyltran GNS1_k127_7081769_0 671143.DAMO_0097 1.69e-199 631.0 COG0019@1|root,COG0019@2|Bacteria,2NNQK@2323|unclassified Bacteria 2|Bacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA1 - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC GNS1_k127_7081769_1 671143.DAMO_0096 8.533e-160 511.0 COG2232@1|root,COG2232@2|Bacteria 2|Bacteria V ATP-grasp domain - - 3.5.4.27 ko:K01499,ko:K06913 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03464 RC01870 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_3 GNS1_k127_7081769_2 671143.DAMO_0095 6.167e-139 446.0 COG1282@1|root,COG1282@2|Bacteria,2NQMF@2323|unclassified Bacteria 2|Bacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB GNS1_k127_7103393_2 671143.DAMO_2081 1.052e-108 359.0 COG0609@1|root,COG0609@2|Bacteria,2NP8A@2323|unclassified Bacteria 2|Bacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily fecD - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD GNS1_k127_7103393_4 745776.DGo_CA0586 0.0001746 48.0 COG1797@1|root,COG1797@2|Bacteria,1WI6N@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 GNS1_k127_7103393_1 671143.DAMO_2082 8.319e-123 400.0 COG0614@1|root,COG0614@2|Bacteria,2NPHH@2323|unclassified Bacteria 2|Bacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 GNS1_k127_7103393_0 671143.DAMO_0102 6.374e-132 447.0 COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria 2|Bacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec GNS1_k127_713335_0 671143.DAMO_2787 2.252e-174 556.0 COG0301@1|root,COG0301@2|Bacteria,2NPBT@2323|unclassified Bacteria 2|Bacteria H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 THUMP,ThiI GNS1_k127_713335_4 1185876.BN8_01697 2.877e-43 170.0 COG2931@1|root,COG2931@2|Bacteria,4P26M@976|Bacteroidetes,47TC4@768503|Cytophagia 976|Bacteroidetes Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - GNS1_k127_713335_2 479434.Sthe_1099 3.557e-101 342.0 COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi,27YWR@189775|Thermomicrobia 189775|Thermomicrobia E NAD(P)-binding Rossmann-like domain - - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO GNS1_k127_713335_1 671143.DAMO_2790 8.289e-120 388.0 COG0518@1|root,COG0518@2|Bacteria,2NPS4@2323|unclassified Bacteria 2|Bacteria F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase GNS1_k127_713335_5 671143.DAMO_2791 6.976e-36 139.0 COG1193@1|root,COG1193@2|Bacteria,2NRN7@2323|unclassified Bacteria 2|Bacteria L Smr domain mutS2 GO:0000018,GO:0008150,GO:0009892,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0080090 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr GNS1_k127_713335_6 983917.RGE_16310 3.529e-12 72.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2VGZB@28216|Betaproteobacteria,1KMIB@119065|unclassified Burkholderiales 28216|Betaproteobacteria H DNA methylase N-4 N-6 - - 2.1.1.72 ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase GNS1_k127_713335_3 861299.J421_5991 3.687e-71 253.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GNS1_k127_7152349_2 671143.DAMO_0011 3.552e-11 71.0 COG1592@1|root,COG1592@2|Bacteria 2|Bacteria C Rubrerythrin - - - - - - - - - - - - Flavin_Reduct,Rubrerythrin GNS1_k127_7152349_1 945713.IALB_2992 1.205e-26 117.0 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - - - - - - - - - - CBS GNS1_k127_7152349_0 661478.OP10G_2366 1.994e-45 173.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase ycgJ_1 - - - - - - - - - - - Methyltransf_11 GNS1_k127_716758_5 671143.DAMO_0884 2.373e-86 291.0 COG2887@1|root,COG2887@2|Bacteria,2NQTZ@2323|unclassified Bacteria 2|Bacteria L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1 GNS1_k127_716758_2 671143.DAMO_0883 6.133e-111 366.0 COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily pksB GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B GNS1_k127_716758_4 867903.ThesuDRAFT_01462 1.667e-87 299.0 COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,3WDS0@538999|Clostridiales incertae sedis 186801|Clostridia P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 GNS1_k127_716758_1 671143.DAMO_0882 8.646e-114 376.0 COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 GNS1_k127_716758_3 1379698.RBG1_1C00001G1220 3.133e-105 351.0 COG0620@1|root,COG0620@2|Bacteria,2NPAE@2323|unclassified Bacteria 2|Bacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_4130,iECO103_1326.ECO103_4334,iECO111_1330.ECO111_4657,iECO26_1355.ECO26_4756,iECW_1372.ECW_m4131,iEKO11_1354.EKO11_4528,iPC815.YPO3788,iWFL_1372.ECW_m4131 Meth_synt_1,Meth_synt_2 GNS1_k127_716758_8 309799.DICTH_1645 5.282e-63 231.0 COG0620@1|root,COG0620@2|Bacteria 2|Bacteria E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 GNS1_k127_716758_7 1162668.LFE_1639 7.38e-74 258.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae 40117|Nitrospirae H Pterin binding enzyme - - 2.1.1.13,2.1.1.258 ko:K00548,ko:K15023 ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230 M00017,M00377 R00946,R02289,R09365,R10243 RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans GNS1_k127_716758_6 314287.GB2207_06743 1.831e-80 281.0 COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,1RN4Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - 3.1.4.54 ko:K13985 ko04723,map04723 - - - ko00000,ko00001,ko01000 - - - Lactamase_B_2 GNS1_k127_716758_0 1183438.GKIL_0310 2.049e-137 459.0 COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1G3GC@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - DUF87,Hydrolase_3 GNS1_k127_716758_9 69293.ENSGACP00000023205 6.411e-53 196.0 COG0491@1|root,KOG0813@2759|Eukaryota,38BZ4@33154|Opisthokonta,3BES6@33208|Metazoa,3CSY3@33213|Bilateria,4893A@7711|Chordata,494N7@7742|Vertebrata,4A1JG@7898|Actinopterygii 33208|Metazoa S Lactamase, beta 2 LACTB2 GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0031974,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 - - - - - - - - - - Lactamase_B GNS1_k127_716758_11 258594.RPA1730 4.911e-08 59.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,3JQSS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O OsmC-like protein MA20_16590 - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC GNS1_k127_716758_10 216591.BCAL1399 1.016e-11 66.0 COG1765@1|root,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2VU1M@28216|Betaproteobacteria,1K8YD@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM OsmC family protein - - - ko:K07397 - - - - ko00000 - - - OsmC GNS1_k127_7297630_2 671143.DAMO_1396 3.603e-119 389.0 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,2NNYG@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid ATP-binding cassette transporter livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iPC815.YPO3806,iSDY_1059.SDY_3605 ABC_tran,BCA_ABC_TP_C,BPD_transp_2,DUF3382 GNS1_k127_7297630_3 671143.DAMO_1395 4.207e-103 341.0 COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria 2|Bacteria E ABC transporter livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C GNS1_k127_7297630_0 671143.DAMO_1394 1.673e-174 555.0 COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria 2|Bacteria E Receptor family ligand binding region livK GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iUTI89_1310.UTI89_C3965,iYL1228.KPN_03820,iZ_1308.Z4834 Peripla_BP_6 GNS1_k127_7297630_4 671143.DAMO_1393 1.916e-69 249.0 COG0009@1|root,COG0009@2|Bacteria,2NPMH@2323|unclassified Bacteria 2|Bacteria J Belongs to the SUA5 family prmC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC GNS1_k127_7297630_1 671143.DAMO_1392 2.995e-157 499.0 COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria 2|Bacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS GNS1_k127_7445125_1 671143.DAMO_2691 7.439e-255 793.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M GNS1_k127_7445125_0 671143.DAMO_2692 8.21e-318 983.0 COG1009@1|root,COG1009@2|Bacteria,2NNU6@2323|unclassified Bacteria 2|Bacteria CP NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015672,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0051179,GO:0051234,GO:0055085,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00341,ko:K12137 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2278,iAF1260.b2278,iBWG_1329.BWG_2052,iECDH10B_1368.ECDH10B_2440,iECDH1ME8569_1439.ECDH1ME8569_2215,iEcDH1_1363.EcDH1_1379,iJN746.PP_4129,iJO1366.b2278,iJR904.b2278,iY75_1357.Y75_RS11945 Proton_antipo_M,Proton_antipo_N GNS1_k127_7556732_6 671143.DAMO_0856 4.891e-30 120.0 COG1522@1|root,COG1522@2|Bacteria 671143.DAMO_0856|- K sequence-specific DNA binding - - - - - - - - - - - - - GNS1_k127_7556732_1 671143.DAMO_0859 1.798e-180 572.0 COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, nitrogen specific, NtrB gnfL - 2.7.13.3 ko:K07708,ko:K10942 ko02020,ko05111,map02020,map05111 M00497,M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 GNS1_k127_7556732_0 671143.DAMO_0860 8.047e-249 774.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family glnG GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712,ko:K07714 ko02020,map02020 M00497,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_7556732_5 246194.CHY_1601 2.923e-56 205.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales 186801|Clostridia I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 GNS1_k127_7556732_4 671143.DAMO_0610 2.735e-76 260.0 COG0494@1|root,COG0494@2|Bacteria,2NPTC@2323|unclassified Bacteria 2|Bacteria L NUDIX domain nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX GNS1_k127_7556732_2 706587.Desti_4650 1.498e-145 476.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M8C@68525|delta/epsilon subdivisions,2WJIB@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,Sigma54_activat GNS1_k127_7556732_3 706587.Desti_4652 6.317e-93 319.0 COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,42TEX@68525|delta/epsilon subdivisions,2WPG8@28221|Deltaproteobacteria,2MRKZ@213462|Syntrophobacterales 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 GNS1_k127_7617012_0 671143.DAMO_1190 1.033e-193 611.0 COG1508@1|root,COG1508@2|Bacteria,2NNZA@2323|unclassified Bacteria 2|Bacteria K RNA polymerase sigma-54 factor rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD GNS1_k127_7617012_3 671143.DAMO_1191 2.295e-45 173.0 COG1544@1|root,COG1544@2|Bacteria,2NPYS@2323|unclassified Bacteria 2|Bacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase raiA - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE GNS1_k127_7617012_5 635013.TherJR_2776 1.156e-21 96.0 COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,261QJ@186807|Peptococcaceae 186801|Clostridia J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE GNS1_k127_7617012_1 671143.DAMO_1192 4.889e-138 443.0 COG1660@1|root,COG1660@2|Bacteria,2NP9G@2323|unclassified Bacteria 2|Bacteria S P-loop ATPase protein family rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 GNS1_k127_7617012_2 671143.DAMO_1193 2.854e-99 330.0 COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria 2|Bacteria H Biotin/lipoate A/B protein ligase family lipM GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB GNS1_k127_7617012_4 1125863.JAFN01000001_gene2272 1.049e-33 150.0 COG0457@1|root,COG0457@2|Bacteria,1R7RK@1224|Proteobacteria,42PPY@68525|delta/epsilon subdivisions,2WKX6@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Tetratricopeptide repeats - - - - - - - - - - - - TPR_11,TPR_16,TPR_19 GNS1_k127_7637688_3 671143.DAMO_0581 5.8e-62 214.0 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 GNS1_k127_7637688_4 671143.DAMO_0580 1.389e-40 151.0 COG0184@1|root,COG0184@2|Bacteria,2NPTZ@2323|unclassified Bacteria 2|Bacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 GNS1_k127_7637688_1 671143.DAMO_0579 2.84e-144 468.0 COG0196@1|root,COG0196@2|Bacteria,2NPCV@2323|unclassified Bacteria 2|Bacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K07011,ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS06310 FAD_syn,Flavokinase GNS1_k127_7637688_0 671143.DAMO_0578 1.176e-163 522.0 COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria 2|Bacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N GNS1_k127_7637688_2 671143.DAMO_0577 3.361e-82 276.0 COG0613@1|root,COG0613@2|Bacteria,2NPEX@2323|unclassified Bacteria 2|Bacteria S DNA polymerase alpha chain like domain trpH - 3.1.3.97,4.1.2.13 ko:K01624,ko:K07053 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R00188,R01068,R01070,R01829,R02568,R11188 RC00078,RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - PHP GNS1_k127_7680250_3 671143.DAMO_0807 4.697e-52 186.0 COG0064@1|root,COG0064@2|Bacteria,2NNPK@2323|unclassified Bacteria 2|Bacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GatB_N,GatB_Yqey GNS1_k127_7680250_2 671143.DAMO_0808 7.857e-64 224.0 COG3703@1|root,COG3703@2|Bacteria 2|Bacteria P gamma-glutamylcyclotransferase activity ykqA - - - - - - - - - - - AIG2_2,GGACT GNS1_k127_7680250_0 671143.DAMO_0810 6.28e-270 837.0 COG0154@1|root,COG0154@2|Bacteria,2NNSD@2323|unclassified Bacteria 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase GNS1_k127_7680250_4 671143.DAMO_0811 6.12e-43 158.0 COG0721@1|root,COG0721@2|Bacteria,2NPXC@2323|unclassified Bacteria 2|Bacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln GNS1_k127_7680250_1 1280390.CBQR020000167_gene4455 4.284e-75 261.0 COG0053@1|root,COG0053@2|Bacteria,1V06K@1239|Firmicutes,4HD66@91061|Bacilli,2726D@186822|Paenibacillaceae 91061|Bacilli P Dimerisation domain of Zinc Transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer GNS1_k127_7691194_0 671143.DAMO_1849 2.857e-152 488.0 COG1063@1|root,COG1063@2|Bacteria,2NPFX@2323|unclassified Bacteria 2|Bacteria E Glucose dehydrogenase C-terminus - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N GNS1_k127_7691194_2 671143.DAMO_1850 5.126e-54 191.0 COG3536@1|root,COG3536@2|Bacteria,2NQ65@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF971) - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - DUF971 GNS1_k127_7691194_1 671143.DAMO_1852 3.768e-145 464.0 COG0190@1|root,COG0190@2|Bacteria,2NNY1@2323|unclassified Bacteria 2|Bacteria E Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C GNS1_k127_7691194_4 671143.DAMO_1853 5.344e-14 71.0 COG1692@1|root,COG1692@2|Bacteria,2NNW9@2323|unclassified Bacteria 2|Bacteria S YmdB-like protein ymdB GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - ko:K02029,ko:K02030,ko:K09769 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - YmdB GNS1_k127_7748892_0 671143.DAMO_2652 4.681e-189 593.0 COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria 2|Bacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N GNS1_k127_7748892_1 671143.DAMO_2653 7.595e-82 275.0 COG0572@1|root,COG0572@2|Bacteria,2NPKT@2323|unclassified Bacteria 2|Bacteria F Phosphoribulokinase / Uridine kinase family udk - 2.7.1.19,2.7.1.48 ko:K00855,ko:K00876 ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200 M00165,M00166 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK GNS1_k127_7782393_3 671143.DAMO_1396 1.242e-172 550.0 COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,2NNYG@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid ATP-binding cassette transporter livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iPC815.YPO3806,iSDY_1059.SDY_3605 ABC_tran,BCA_ABC_TP_C,BPD_transp_2,DUF3382 GNS1_k127_7782393_4 671143.DAMO_1397 3.172e-151 483.0 COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid transport system / permease component livH GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288 BPD_transp_2 GNS1_k127_7782393_1 671143.DAMO_1398 7.696e-191 602.0 COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria 2|Bacteria E Receptor family ligand binding region livK GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iUTI89_1310.UTI89_C3965,iYL1228.KPN_03820,iZ_1308.Z4834 Peripla_BP_6 GNS1_k127_7782393_6 671143.DAMO_1399 1.375e-88 296.0 COG0352@1|root,COG0352@2|Bacteria,2NPCU@2323|unclassified Bacteria 2|Bacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00788,ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI GNS1_k127_7782393_2 1232410.KI421416_gene2550 8.625e-182 579.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,43TSY@69541|Desulfuromonadales 28221|Deltaproteobacteria I Carbamoyl-phosphate synthetase large chain domain protein accC - 6.3.4.14,6.4.1.1,6.4.1.2 ko:K01959,ko:K01961 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 GNS1_k127_7782393_10 1121430.JMLG01000003_gene572 2.566e-37 145.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,260JY@186807|Peptococcaceae 186801|Clostridia CI Acetyl-CoA carboxylase, biotin carboxyl carrier protein pycB - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA GNS1_k127_7782393_7 671143.DAMO_1400 1.358e-87 292.0 COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria 2|Bacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C GNS1_k127_7782393_8 671143.DAMO_1401 7.301e-67 230.0 COG0757@1|root,COG0757@2|Bacteria,2NPMW@2323|unclassified Bacteria 2|Bacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 3.4.13.9,4.2.1.10 ko:K01271,ko:K03785,ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000,ko01002 - - iIT341.HP1038,iJN746.PP_0560,iLJ478.TM0349 DHquinase_II GNS1_k127_7782393_11 398767.Glov_1593 4.197e-06 58.0 COG4783@1|root,COG4783@2|Bacteria,1QZ64@1224|Proteobacteria,43CH3@68525|delta/epsilon subdivisions,2X7SA@28221|Deltaproteobacteria,43VYR@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - GNS1_k127_7782393_5 1121468.AUBR01000002_gene704 4.363e-109 365.0 COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,42FJ5@68295|Thermoanaerobacterales 186801|Clostridia E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase GNS1_k127_7782393_9 1123250.KB908379_gene1142 3.569e-42 162.0 COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,4H4XC@909932|Negativicutes 909932|Negativicutes E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI GNS1_k127_7782393_0 671143.DAMO_1404 1.873e-204 643.0 COG0082@1|root,COG0082@2|Bacteria,2NNQ8@2323|unclassified Bacteria 2|Bacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0976,iNJ661.Rv2540c Chorismate_synt GNS1_k127_7782393_12 671143.DAMO_1405 0.0001025 46.0 COG5426@1|root,COG5426@2|Bacteria 2|Bacteria D von Willebrand factor, type A - - - - - - - - - - - - - GNS1_k127_7792634_2 671143.DAMO_1854 1.207e-25 109.0 COG1418@1|root,COG4372@1|root,COG1418@2|Bacteria,COG4372@2|Bacteria,2NNU5@2323|unclassified Bacteria 2|Bacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K05802,ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko02000,ko03019 1.A.23.1.1 - - DUF3552,HD,KH_1 GNS1_k127_7792634_1 671143.DAMO_1855 1.543e-30 122.0 COG3027@1|root,COG3027@2|Bacteria 2|Bacteria D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA GNS1_k127_7792634_0 671143.DAMO_1857 2.269e-239 750.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2NNXI@2323|unclassified Bacteria 2|Bacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind GNS1_k127_7797978_7 671143.DAMO_2211 6.89e-26 112.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 GNS1_k127_7797978_4 1111479.AXAR01000014_gene1159 4.854e-33 138.0 COG4493@1|root,COG4493@2|Bacteria,1UY83@1239|Firmicutes,4HEDB@91061|Bacilli,278KF@186823|Alicyclobacillaceae 91061|Bacilli S Protein of unknown function (DUF1054) yktB - - - - - - - - - - - DUF1054 GNS1_k127_7797978_1 326427.Cagg_1618 4.781e-77 267.0 COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi,374RX@32061|Chloroflexia 32061|Chloroflexia P PFAM Rhodanese domain protein - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese GNS1_k127_7797978_5 671143.DAMO_2687 7.155e-32 126.0 COG2161@1|root,COG2161@2|Bacteria 2|Bacteria D toxin-antitoxin pair type II binding relF GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 - - - PhdYeFM_antitox GNS1_k127_7797978_3 671143.DAMO_2686 5.248e-35 136.0 COG2026@1|root,COG2026@2|Bacteria 2|Bacteria DJ nuclease activity relE GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin GNS1_k127_7797978_2 671143.DAMO_2921 5.882e-37 141.0 COG1254@1|root,COG1254@2|Bacteria,2NQ0Z@2323|unclassified Bacteria 2|Bacteria C Acylphosphatase acyP GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase GNS1_k127_7797978_0 671143.DAMO_2922 1.07e-156 500.0 COG1562@1|root,COG1562@2|Bacteria,2NQ18@2323|unclassified Bacteria 2|Bacteria I Squalene/phytoene synthase crtB GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99 ko:K00801,ko:K02291,ko:K10208 ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130 M00097 R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177 RC00362,RC00796,RC01101,RC02839,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY GNS1_k127_7797978_6 1173026.Glo7428_3974 1.785e-31 125.0 COG0778@1|root,COG0778@2|Bacteria,1G42X@1117|Cyanobacteria 1117|Cyanobacteria C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase GNS1_k127_7825655_6 5062.CADAORAP00007367 2.677e-35 138.0 COG5496@1|root,2SETH@2759|Eukaryota,38TIT@33154|Opisthokonta,3PV7C@4751|Fungi,3R4VG@4890|Ascomycota 4751|Fungi - - - - - - - - - - - - - - - GNS1_k127_7825655_3 1121403.AUCV01000019_gene3293 1.177e-76 269.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,43AR4@68525|delta/epsilon subdivisions,2X652@28221|Deltaproteobacteria,2MPGX@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 GNS1_k127_7825655_1 706587.Desti_4654 1.049e-82 290.0 COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,43CKB@68525|delta/epsilon subdivisions,2X60U@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 GNS1_k127_7825655_4 913865.DOT_4545 2.473e-68 245.0 COG0411@1|root,COG0411@2|Bacteria,1V7H4@1239|Firmicutes,2510H@186801|Clostridia,265BZ@186807|Peptococcaceae 186801|Clostridia E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C GNS1_k127_7825655_2 706587.Desti_4656 2.659e-82 279.0 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,42R5R@68525|delta/epsilon subdivisions,2WMRR@28221|Deltaproteobacteria,2MR65@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran GNS1_k127_7825655_0 387631.Asulf_01574 4.004e-135 449.0 COG1804@1|root,arCOG02304@2157|Archaea,2XTW7@28890|Euryarchaeota,246VM@183980|Archaeoglobi 183980|Archaeoglobi C PFAM L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 GNS1_k127_7825655_5 1121468.AUBR01000039_gene1940 4.003e-49 181.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia 186801|Clostridia C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 GNS1_k127_7842043_1 330214.NIDE1363 5.027e-85 282.0 COG0174@1|root,COG0174@2|Bacteria,3J0AS@40117|Nitrospirae 40117|Nitrospirae E Glutamine synthetase, catalytic domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N GNS1_k127_7842043_0 330214.NIDE1362 0.0 1078.0 COG2844@1|root,COG2844@2|Bacteria 2|Bacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.42,2.7.7.59,2.7.7.89 ko:K00982,ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 GNS1_k127_7842043_2 330214.NIDE1361 7.918e-52 184.0 COG0347@1|root,COG0347@2|Bacteria,3J0P1@40117|Nitrospirae 40117|Nitrospirae K Nitrogen regulatory protein P-II - - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II GNS1_k127_7861999_9 243231.GSU0770 3.289e-24 106.0 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,42U5I@68525|delta/epsilon subdivisions,2WQV6@28221|Deltaproteobacteria,43UHI@69541|Desulfuromonadales 28221|Deltaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N GNS1_k127_7861999_7 1265505.ATUG01000001_gene4613 1.208e-67 243.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,42PMY@68525|delta/epsilon subdivisions,2WPU5@28221|Deltaproteobacteria,2MM4P@213118|Desulfobacterales 28221|Deltaproteobacteria G Polysaccharide deacetylase - - - ko:K11931 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - Polysacc_deac_1 GNS1_k127_7861999_5 933262.AXAM01000006_gene1837 2.166e-74 269.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2WPIY@28221|Deltaproteobacteria,2MPS7@213118|Desulfobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP GNS1_k127_7861999_1 671143.DAMO_2595 4.189e-223 698.0 COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_7861999_10 671143.DAMO_2594 2.621e-22 105.0 COG0745@1|root,COG0745@2|Bacteria 671143.DAMO_2594|- T phosphorelay signal transduction system - - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - - GNS1_k127_7861999_0 671143.DAMO_2593 2.226e-234 747.0 COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,2NS4N@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - 2.7.13.3 ko:K03407,ko:K07678,ko:K18143 ko01501,ko02020,ko02025,ko02026,ko02030,ko05111,map01501,map02020,map02025,map02026,map02030,map05111 M00475,M00506,M00649,M00655 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022,ko02035 - - - 4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 GNS1_k127_7861999_3 671143.DAMO_2592 1.261e-143 461.0 COG2984@1|root,COG2984@2|Bacteria,2NPCT@2323|unclassified Bacteria 2|Bacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind GNS1_k127_7861999_2 671143.DAMO_2591 9.734e-196 619.0 2E0UX@1|root,32WC9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Phenol_MetA_deg GNS1_k127_7861999_4 671143.DAMO_2401 1.037e-132 426.0 COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria 2|Bacteria K Transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg GNS1_k127_7861999_6 671143.DAMO_2402 1.087e-72 248.0 COG0817@1|root,COG0817@2|Bacteria,2NPKS@2323|unclassified Bacteria 2|Bacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC GNS1_k127_7861999_8 671143.DAMO_2403 7.593e-63 222.0 COG0632@1|root,COG0632@2|Bacteria,2NPR6@2323|unclassified Bacteria 2|Bacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N GNS1_k127_7864160_1 671143.DAMO_1848 2.15e-101 334.0 COG1063@1|root,COG1063@2|Bacteria,2NR1V@2323|unclassified Bacteria 2|Bacteria E Zinc-binding dehydrogenase - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N GNS1_k127_7864160_2 289376.THEYE_A1303 1.514e-90 310.0 COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae 40117|Nitrospirae C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C GNS1_k127_7864160_4 1261545.MBE-HAL_0952 0.0003507 45.0 arCOG02989@1|root,arCOG02989@2157|Archaea,2Y00B@28890|Euryarchaeota,23XHN@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - DUF1931 GNS1_k127_7864160_0 671143.DAMO_1846 6.933e-169 536.0 COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria 2|Bacteria M Transglycosylase mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase GNS1_k127_7902429_1 671143.DAMO_1640 2.817e-131 424.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - ko:K02841,ko:K02843,ko:K02849,ko:K12982 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 GNS1_k127_7902429_5 1382306.JNIM01000001_gene434 1.263e-08 64.0 COG0451@1|root,COG0451@2|Bacteria,2G6S4@200795|Chloroflexi 200795|Chloroflexi M Short-chain dehydrogenase reductase SDR - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd GNS1_k127_7902429_4 1380386.JIAW01000018_gene3002 3.326e-10 62.0 COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,23882@1762|Mycobacteriaceae 201174|Actinobacteria M RmlD substrate binding domain - - - - - - - - - - - - Epimerase,GDP_Man_Dehyd GNS1_k127_7902429_2 671143.DAMO_1639 2.116e-129 418.0 COG1355@1|root,COG1355@2|Bacteria,2NQ00@2323|unclassified Bacteria 2|Bacteria S Evidence 4 Homologs of previously reported genes of - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - ko:K06990 - - - - ko00000,ko04812 - - - Memo GNS1_k127_7902429_3 304371.MCP_0927 7.53e-80 280.0 COG3391@1|root,arCOG02562@2157|Archaea,2Y7T2@28890|Euryarchaeota,2NBM7@224756|Methanomicrobia 224756|Methanomicrobia S Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Lactonase GNS1_k127_7902429_0 671143.DAMO_1637 2.435e-157 501.0 COG0709@1|root,COG0709@2|Bacteria,2NNUD@2323|unclassified Bacteria 2|Bacteria E Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C GNS1_k127_7925354_1 671143.DAMO_2468 5.918e-199 623.0 COG0821@1|root,COG0821@2|Bacteria,2NNPV@2323|unclassified Bacteria 2|Bacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430,iJN678.gcpE GcpE GNS1_k127_7925354_3 1123276.KB893247_gene222 6.526e-23 102.0 COG3411@1|root,COG3411@2|Bacteria,4NT2H@976|Bacteroidetes,47R8Z@768503|Cytophagia 976|Bacteroidetes C Ferredoxin - - - - - - - - - - - - - GNS1_k127_7925354_0 671143.DAMO_2469 2.109e-306 947.0 COG0442@1|root,COG0442@2|Bacteria,2NNNH@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit GNS1_k127_7925354_2 1262915.BN574_00366 3.972e-27 112.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4H5K5@909932|Negativicutes 909932|Negativicutes K Cold-shock DNA-binding domain protein cspB - - ko:K03704 - - - - ko00000,ko03000 - - - CSD GNS1_k127_7925354_7 1121937.AUHJ01000020_gene1283 1.106e-11 66.0 COG5487@1|root,COG5487@2|Bacteria,1PCW4@1224|Proteobacteria,1T6EH@1236|Gammaproteobacteria,46CAM@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1328) - - - - - - - - - - - - DUF1328 GNS1_k127_7925354_4 232721.Ajs_0254 4.554e-20 92.0 COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2VW2V@28216|Betaproteobacteria,4AFCQ@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0337 (CsbD) family - - - - - - - - - - - - CsbD GNS1_k127_7925354_5 1121937.AUHJ01000020_gene1283 3.447e-15 76.0 COG5487@1|root,COG5487@2|Bacteria,1PCW4@1224|Proteobacteria,1T6EH@1236|Gammaproteobacteria,46CAM@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1328) - - - - - - - - - - - - DUF1328 GNS1_k127_7925354_6 525368.HMPREF0591_0320 6.67e-12 66.0 2BMG4@1|root,32G0U@2|Bacteria,2H148@201174|Actinobacteria,23C1R@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - GNS1_k127_7945897_4 525904.Tter_1203 8.961e-32 130.0 COG1051@1|root,COG1051@2|Bacteria,2NQ7Y@2323|unclassified Bacteria 2|Bacteria F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX GNS1_k127_7945897_6 671143.DAMO_2566 3.849e-19 93.0 COG2104@1|root,COG2104@2|Bacteria 2|Bacteria H thiamine diphosphate biosynthetic process thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS GNS1_k127_7945897_0 671143.DAMO_2565 5.594e-140 447.0 COG2022@1|root,COG2022@2|Bacteria,2NQHA@2323|unclassified Bacteria 2|Bacteria H Thiazole biosynthesis protein ThiG thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS GNS1_k127_7945897_1 671143.DAMO_2564 7.247e-71 247.0 COG0352@1|root,COG0352@2|Bacteria,2NPCU@2323|unclassified Bacteria 2|Bacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI GNS1_k127_7945897_3 671143.DAMO_2562 2.581e-38 146.0 COG0776@1|root,COG0776@2|Bacteria,2NPTH@2323|unclassified Bacteria 2|Bacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530,ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding GNS1_k127_7945897_5 525897.Dbac_2186 1.2e-24 104.0 2DRFV@1|root,33BJD@2|Bacteria,1NM2T@1224|Proteobacteria,42WGX@68525|delta/epsilon subdivisions,2WR8G@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - GNS1_k127_7945897_7 1121937.AUHJ01000020_gene1283 1.248e-17 83.0 COG5487@1|root,COG5487@2|Bacteria,1PCW4@1224|Proteobacteria,1T6EH@1236|Gammaproteobacteria,46CAM@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1328) - - - - - - - - - - - - DUF1328 GNS1_k127_7945897_8 596151.DesfrDRAFT_1807 1.843e-09 59.0 2AEVA@1|root,314ST@2|Bacteria,1PUP4@1224|Proteobacteria,4369S@68525|delta/epsilon subdivisions,2X0UI@28221|Deltaproteobacteria,2MDFU@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF3096) - - - - - - - - - - - - DUF3096 GNS1_k127_7945897_2 671143.DAMO_2551 5.275e-52 184.0 COG1250@1|root,COG1250@2|Bacteria,2NP11@2323|unclassified Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N GNS1_k127_8118730_1 671143.DAMO_0743 4.63e-112 389.0 COG0642@1|root,COG0784@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,2NNXM@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain barA - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 GNS1_k127_8118730_2 420324.KI912061_gene6193 2.12e-46 172.0 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2UD5E@28211|Alphaproteobacteria,1JV34@119045|Methylobacteriaceae 28211|Alphaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg GNS1_k127_8118730_0 663610.JQKO01000015_gene1908 1.617e-144 467.0 COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,3N9KG@45404|Beijerinckiaceae 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,Response_reg GNS1_k127_8118730_3 102129.Lepto7375DRAFT_6051 0.0001843 46.0 COG2200@1|root,COG2200@2|Bacteria,1G38W@1117|Cyanobacteria 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,cNMP_binding GNS1_k127_8165524_4 644282.Deba_2016 1.618e-21 105.0 COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WKB3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PBS lyase HEAT domain protein repeat-containing protein - - - - - - - - - - - - HEAT_2,HEAT_PBS GNS1_k127_8165524_2 330214.NIDE0699 8.949e-69 249.0 COG2324@1|root,COG2324@2|Bacteria,3J195@40117|Nitrospirae 40117|Nitrospirae S Carotenoid biosynthesis protein - - - - - - - - - - - - Caroten_synth GNS1_k127_8165524_1 1303518.CCALI_00063 3.224e-139 451.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein hpnH - - - - - - - - - - - DUF3463,Fer4_12,Fer4_14,Radical_SAM GNS1_k127_8165524_0 671143.DAMO_0045 0.0 1073.0 COG1657@1|root,COG1657@2|Bacteria 2|Bacteria I PFAM Prenyltransferase squalene oxidase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N GNS1_k127_8165524_5 697282.Mettu_0709 1.757e-17 95.0 COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,1THNW@1236|Gammaproteobacteria,1XF47@135618|Methylococcales 135618|Methylococcales F TIGRFAM Hopanoid-associated phosphorylase - - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 GNS1_k127_8165524_3 671143.DAMO_2628 1.413e-49 180.0 2ENGZ@1|root,33G4G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_8172163_21 671143.DAMO_2752 1.285e-36 145.0 COG5512@1|root,COG5512@2|Bacteria 2|Bacteria L Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - - - - - - - - - - DUF721 GNS1_k127_8172163_20 671143.DAMO_2753 9.528e-48 178.0 COG0328@1|root,COG0328@2|Bacteria,2NQ7I@2323|unclassified Bacteria 2|Bacteria L Reverse transcriptase-like rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 ko:K03469,ko:K06864,ko:K22316 ko00860,ko01100,ko03030,map00860,map01100,map03030 M00122 R04594 RC00017 ko00000,ko00001,ko00002,ko01000,ko03032 - - - His_Phos_1,RVT_3 GNS1_k127_8172163_16 671143.DAMO_2754 7.486e-74 255.0 COG1579@1|root,COG1579@2|Bacteria,2NPW0@2323|unclassified Bacteria 2|Bacteria S C4-type zinc ribbon domain CP_0228 - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 GNS1_k127_8172163_3 671143.DAMO_2755 2.744e-283 887.0 COG0568@1|root,COG0568@2|Bacteria,2NNY9@2323|unclassified Bacteria 2|Bacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 GNS1_k127_8172163_12 330214.NIDE0989 4.478e-108 373.0 COG0358@1|root,COG0358@2|Bacteria,3J0IN@40117|Nitrospirae 40117|Nitrospirae L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4,Toprim_N,zf-CHC2 GNS1_k127_8172163_1 671143.DAMO_2757 0.0 1020.0 COG1193@1|root,COG1193@2|Bacteria,2NNS1@2323|unclassified Bacteria 2|Bacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr GNS1_k127_8172163_18 671143.DAMO_2759 8.955e-63 218.0 COG1610@1|root,COG1610@2|Bacteria,2NPQ9@2323|unclassified Bacteria 2|Bacteria S Yqey-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY GNS1_k127_8172163_24 671143.DAMO_2760 1.582e-20 93.0 COG0828@1|root,COG0828@2|Bacteria,2NQ1U@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein S21 rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 GNS1_k127_8172163_28 478749.BRYFOR_06510 6.493e-05 48.0 COG2026@1|root,COG2026@2|Bacteria,1VBJJ@1239|Firmicutes,24NYG@186801|Clostridia 186801|Clostridia DJ Addiction module toxin, RelE StbE family - - - - - - - - - - - - ParE_toxin,YafQ_toxin GNS1_k127_8172163_10 1379698.RBG1_1C00001G1265 4.498e-138 453.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_8172163_17 1379698.RBG1_1C00001G1199 9.271e-69 257.0 COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, nitrogen specific, NtrB - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9 GNS1_k127_8172163_13 671143.DAMO_3001 6.444e-108 356.0 COG1989@1|root,COG1989@2|Bacteria,2NPDS@2323|unclassified Bacteria 2|Bacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02236,ko:K02278,ko:K02506,ko:K02654,ko:K10966 - M00331,M00429 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 GNS1_k127_8172163_23 330214.NIDE3436 6.191e-26 117.0 COG0457@1|root,COG0457@2|Bacteria 330214.NIDE3436|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GNS1_k127_8172163_19 1265505.ATUG01000003_gene184 6.164e-60 216.0 COG1277@1|root,COG1277@2|Bacteria,1NCXV@1224|Proteobacteria,42VK2@68525|delta/epsilon subdivisions,2WRNT@28221|Deltaproteobacteria,2MPXF@213118|Desulfobacterales 28221|Deltaproteobacteria S ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - - - - - - - - - - ABC2_membrane_2 GNS1_k127_8172163_15 330214.NIDE3435 6.68e-89 303.0 COG1131@1|root,COG1131@2|Bacteria,3J122@40117|Nitrospirae 40117|Nitrospirae V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GNS1_k127_8172163_27 1499967.BAYZ01000075_gene2072 1.134e-09 65.0 COG2165@1|root,COG2165@2|Bacteria,2NQ2Y@2323|unclassified Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pulG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG GNS1_k127_8172163_25 439235.Dalk_4888 1.475e-14 88.0 COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria 2|Bacteria M -O-antigen - - - - - - - - - - - - Wzy_C GNS1_k127_8172163_9 330214.NIDE0779 1.564e-142 466.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat GNS1_k127_8172163_5 671143.DAMO_3010 4.144e-235 739.0 COG5000@1|root,COG5000@2|Bacteria,2NP6K@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 GNS1_k127_8172163_8 671143.DAMO_3011 1.497e-178 568.0 COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria 2|Bacteria U Type II secretion system (T2SS), protein F pilC - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF GNS1_k127_8172163_7 671143.DAMO_3012 2.547e-183 578.0 COG2805@1|root,COG2805@2|Bacteria,2NNR7@2323|unclassified Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE GNS1_k127_8172163_4 671143.DAMO_3013 1.364e-280 871.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain pilB - - ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N GNS1_k127_8172163_11 671143.DAMO_3014 1.262e-121 396.0 COG0169@1|root,COG0169@2|Bacteria,2NPR3@2323|unclassified Bacteria 2|Bacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N GNS1_k127_8172163_0 671143.DAMO_3015 0.0 1340.0 COG2844@1|root,COG2844@2|Bacteria 2|Bacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 GNS1_k127_8172163_2 671143.DAMO_2682 3.71e-288 888.0 COG0043@1|root,COG0043@2|Bacteria,2NPAD@2323|unclassified Bacteria 2|Bacteria H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4669,iIT341.HP0396 UbiD GNS1_k127_8172163_26 671143.DAMO_2683 1.493e-12 70.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Cu2_monoox_C,EF-hand_5 GNS1_k127_8172163_22 671143.DAMO_2684 1.962e-29 119.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity mauD - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA GNS1_k127_8172163_14 671143.DAMO_2689 2.89e-99 329.0 COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria 2|Bacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N GNS1_k127_8172163_6 671143.DAMO_2690 4.973e-214 673.0 COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M GNS1_k127_8173317_3 671143.DAMO_2403 1.472e-36 140.0 COG0632@1|root,COG0632@2|Bacteria,2NPR6@2323|unclassified Bacteria 2|Bacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N GNS1_k127_8173317_0 671143.DAMO_2404 1.126e-193 608.0 COG2255@1|root,COG2255@2|Bacteria,2NNUG@2323|unclassified Bacteria 2|Bacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N GNS1_k127_8173317_4 671143.DAMO_2405 1.017e-27 113.0 29Y14@1|root,30JU1@2|Bacteria,2NRYB@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 GNS1_k127_8173317_2 1120985.AUMI01000015_gene1369 2.01e-104 351.0 COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,4H1WD@909932|Negativicutes 909932|Negativicutes H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth GNS1_k127_8173317_1 671143.DAMO_2407 1.804e-134 431.0 COG0343@1|root,COG0343@2|Bacteria,2NNQS@2323|unclassified Bacteria 2|Bacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT GNS1_k127_8203702_2 671143.DAMO_0314 1.061e-156 501.0 COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ GNS1_k127_8203702_1 335543.Sfum_0366 3.821e-195 616.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MQA7@213462|Syntrophobacterales 28221|Deltaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD GNS1_k127_8203702_0 671143.DAMO_0276 1.646e-227 707.0 COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria 2|Bacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N GNS1_k127_822166_2 671143.DAMO_2996 0.0 1054.0 COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria 2|Bacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM GNS1_k127_822166_4 671143.DAMO_2625 3.873e-154 490.0 COG1210@1|root,COG1210@2|Bacteria,2NNV4@2323|unclassified Bacteria 2|Bacteria M Nucleotidyl transferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase GNS1_k127_822166_0 671143.DAMO_2624 0.0 1399.0 COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria 2|Bacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C GNS1_k127_822166_3 671143.DAMO_2623 9.215e-260 813.0 COG0595@1|root,COG0595@2|Bacteria,2NNMI@2323|unclassified Bacteria 2|Bacteria S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL GNS1_k127_822166_1 671143.DAMO_2622 0.0 1100.0 COG1674@1|root,COG1674@2|Bacteria,2NNVB@2323|unclassified Bacteria 2|Bacteria D Ftsk_gamma ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma GNS1_k127_822166_6 671143.DAMO_2621 3.13e-91 307.0 COG2834@1|root,COG2834@2|Bacteria,2NQ6V@2323|unclassified Bacteria 2|Bacteria M Outer membrane lipoprotein carrier protein LolA lolA - - ko:K03634 - - - - ko00000 - - - LolA GNS1_k127_822166_7 671143.DAMO_2620 2.429e-70 242.0 COG1666@1|root,COG1666@2|Bacteria,2NRMV@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF520) yajQ GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K09767 - - - - ko00000 - - - DUF520 GNS1_k127_822166_5 671143.DAMO_2619 1.685e-126 434.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria 2|Bacteria T diguanylate cyclase - - - - - - - - - - - - GAF,GAF_2,GAF_3,GGDEF,PAS_3,PAS_7,Response_reg GNS1_k127_822166_8 667014.Thein_0915 3.929e-24 108.0 COG1267@1|root,COG1267@2|Bacteria,2GHUX@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria I Phosphatidylglycerophosphatase A - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA GNS1_k127_826771_1 886293.Sinac_4869 2.014e-84 289.0 COG0583@1|root,COG0583@2|Bacteria,2IYFV@203682|Planctomycetes 203682|Planctomycetes K COG0583 Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate GNS1_k127_826771_0 671143.DAMO_0867 1.296e-152 486.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2NP08@2323|unclassified Bacteria 2|Bacteria E Glutamate synthase central domain gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase GNS1_k127_8286038_3 443143.GM18_4151 1.39e-53 194.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2WMNR@28221|Deltaproteobacteria 28221|Deltaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase GNS1_k127_8286038_2 671143.DAMO_2243 2.444e-100 331.0 COG0131@1|root,COG0131@2|Bacteria,2NPI3@2323|unclassified Bacteria 2|Bacteria E Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P GNS1_k127_8286038_0 671143.DAMO_2244 7.738e-167 531.0 COG0079@1|root,COG0079@2|Bacteria,2NPHF@2323|unclassified Bacteria 2|Bacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 GNS1_k127_8286038_1 671143.DAMO_2245 2.054e-122 395.0 COG0141@1|root,COG0141@2|Bacteria,2NNTS@2323|unclassified Bacteria 2|Bacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS14140,iYO844.BSU34910 Histidinol_dh GNS1_k127_8297447_2 1033743.CAES01000002_gene1862 1.561e-39 163.0 COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,4HA0U@91061|Bacilli,26WHS@186822|Paenibacillaceae 91061|Bacilli G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 GNS1_k127_8297447_0 1411123.JQNH01000001_gene709 1.27e-99 340.0 COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2U05K@28211|Alphaproteobacteria 28211|Alphaproteobacteria G ABC-type sugar transport system periplasmic component - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,TAT_signal GNS1_k127_8297447_1 292459.STH3215 2.142e-43 163.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia 186801|Clostridia CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C GNS1_k127_8311017_10 671143.DAMO_1586 9.528e-31 124.0 COG3088@1|root,COG3088@2|Bacteria,2NRBD@2323|unclassified Bacteria 2|Bacteria P subunit of a heme lyase ccmH - - ko:K02198,ko:K02200 - - - - ko00000,ko02000 9.B.14.1 - - CcmH GNS1_k127_8311017_9 869210.Marky_1973 3.129e-45 174.0 COG0526@1|root,COG0526@2|Bacteria,1WJ2P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus CO periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily ccmG - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA GNS1_k127_8311017_0 671143.DAMO_1588 0.0 1035.0 COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198,ko:K04016 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm GNS1_k127_8311017_8 671143.DAMO_1589 2.446e-55 199.0 COG2332@1|root,COG2332@2|Bacteria 2|Bacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE GNS1_k127_8311017_5 671143.DAMO_1590 2.58e-108 354.0 COG0755@1|root,COG0755@2|Bacteria,2NPG8@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmC GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm GNS1_k127_8311017_4 671143.DAMO_1591 3.448e-111 364.0 COG2386@1|root,COG2386@2|Bacteria,2NPSF@2323|unclassified Bacteria 2|Bacteria O CcmB protein ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193,ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936,iYL1228.KPN_02080 CcmB GNS1_k127_8311017_6 671143.DAMO_1592 3.784e-99 331.0 COG1131@1|root,COG1131@2|Bacteria,2NR7X@2323|unclassified Bacteria 2|Bacteria V AAA domain, putative AbiEii toxin, Type IV TA system ccmA - 3.6.3.41 ko:K01990,ko:K02193 ko02010,map02010 M00254,M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.107 - - ABC_tran GNS1_k127_8311017_11 867903.ThesuDRAFT_01328 1.122e-06 57.0 COG5615@1|root,COG5615@2|Bacteria 2|Bacteria L integral membrane protein - - - - - - - - - - - - CopD GNS1_k127_8311017_3 671143.DAMO_1593 5.216e-152 486.0 COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria 2|Bacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg GNS1_k127_8311017_7 671143.DAMO_1594 1.688e-90 304.0 COG0321@1|root,COG0321@2|Bacteria,2NPE7@2323|unclassified Bacteria 2|Bacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181,2.8.1.8 ko:K03644,ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07767,R07768,R07769 RC00039,RC00992,RC01978,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB GNS1_k127_8311017_1 671143.DAMO_1595 7.071e-213 669.0 COG1249@1|root,COG1249@2|Bacteria,2NNTI@2323|unclassified Bacteria 2|Bacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain lpd GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0016667,GO:0016668,GO:0019725,GO:0019899,GO:0032991,GO:0035375,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070404,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim GNS1_k127_8311017_2 671143.DAMO_1599 1.926e-156 498.0 COG0320@1|root,COG0320@2|Bacteria,2NNPI@2323|unclassified Bacteria 2|Bacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM GNS1_k127_8320226_2 671143.DAMO_2479 7.72e-43 160.0 COG1450@1|root,COG1450@2|Bacteria,2NQ01@2323|unclassified Bacteria 2|Bacteria NU Bacterial type II and III secretion system protein gspD - - ko:K02453,ko:K03219 ko03070,ko05111,map03070,map05111 M00331,M00332,M00542 - - ko00000,ko00001,ko00002,ko02044 3.A.15,3.A.6.1,3.A.6.3 - - Secretin,Secretin_N GNS1_k127_8320226_0 671143.DAMO_0220 5.963e-124 408.0 COG0438@1|root,COG0438@2|Bacteria,2NR65@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 GNS1_k127_8320226_3 671143.DAMO_0230 1.62e-15 82.0 COG4083@1|root,COG4083@2|Bacteria 2|Bacteria S PFAM Transmembrane exosortase (Exosortase_EpsH) groEL - - - - - - - - - - - Exosortase_EpsH GNS1_k127_8435885_4 671143.DAMO_2778 1.526e-191 603.0 COG1209@1|root,COG1209@2|Bacteria,2NNTJ@2323|unclassified Bacteria 2|Bacteria M Nucleotidyl transferase rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase GNS1_k127_8435885_8 671143.DAMO_3152 1.668e-59 209.0 COG1371@1|root,COG1371@2|Bacteria,2NPX9@2323|unclassified Bacteria 2|Bacteria S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease GNS1_k127_8435885_3 671143.DAMO_3153 6.724e-199 628.0 COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain salY - - ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 - - FtsX,MacB_PCD GNS1_k127_8435885_5 671143.DAMO_3154 6.549e-112 365.0 COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria 2|Bacteria V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GNS1_k127_8435885_2 671143.DAMO_3155 4.755e-223 699.0 COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion macA_1 - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_D23 GNS1_k127_8435885_1 671143.DAMO_3156 2.19e-233 733.0 COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria 2|Bacteria MU Outer membrane efflux protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP GNS1_k127_8435885_9 671143.DAMO_3157 8.478e-51 185.0 28VYX@1|root,2ZI05@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GNS1_k127_8435885_7 671143.DAMO_3159 3.313e-79 274.0 COG1595@1|root,COG1595@2|Bacteria,2NR5T@2323|unclassified Bacteria 2|Bacteria K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GNS1_k127_8435885_0 671143.DAMO_3171 9.922e-253 788.0 COG0277@1|root,COG0277@2|Bacteria,2NP2P@2323|unclassified Bacteria 2|Bacteria C FAD linked oxidases, C-terminal domain glcD GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 ko:K00102,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 - - iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750 FAD-oxidase_C,FAD_binding_4 GNS1_k127_8435885_6 671143.DAMO_3031 6.075e-111 365.0 COG0247@1|root,COG0247@2|Bacteria,2NNU8@2323|unclassified Bacteria 2|Bacteria C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 GNS1_k127_8439771_2 671143.DAMO_2845 6.68e-76 261.0 COG0617@1|root,COG0617@2|Bacteria,2NQ0U@2323|unclassified Bacteria 2|Bacteria J Poly A polymerase head domain cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd GNS1_k127_8439771_1 671143.DAMO_2846 1.595e-105 345.0 COG1994@1|root,COG1994@2|Bacteria,2NPQP@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 ywhC - - - - - - - - - - - Peptidase_M50 GNS1_k127_8439771_0 671143.DAMO_2847 6.529e-191 598.0 COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria 2|Bacteria J tRNA synthetases class I (W and Y) trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b GNS1_k127_8439771_3 671143.DAMO_2848 6.132e-08 53.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2NNX4@2323|unclassified Bacteria 2|Bacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO GNS1_k127_8467204_9 671143.DAMO_2653 1.435e-19 88.0 COG0572@1|root,COG0572@2|Bacteria,2NPKT@2323|unclassified Bacteria 2|Bacteria F Phosphoribulokinase / Uridine kinase family udk - 2.7.1.19,2.7.1.48 ko:K00855,ko:K00876 ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200 M00165,M00166 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK GNS1_k127_8467204_10 529709.PYCH_01680 0.0006148 46.0 COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,242XH@183968|Thermococci 183968|Thermococci K Helix-turn-helix domain - - - - - - - - - - - - CBS,HTH_3 GNS1_k127_8467204_7 671143.DAMO_0861 5.345e-65 234.0 COG0583@1|root,COG0583@2|Bacteria,2NR37@2323|unclassified Bacteria 2|Bacteria K LysR substrate binding domain cbbR - - ko:K21703,ko:K21711 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate GNS1_k127_8467204_6 671143.DAMO_2655 1.479e-70 242.0 COG0720@1|root,COG0720@2|Bacteria,2NR6T@2323|unclassified Bacteria 2|Bacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS GNS1_k127_8467204_5 671143.DAMO_2656 7.089e-79 271.0 COG1411@1|root,COG1411@2|Bacteria 2|Bacteria C Belongs to the HisA HisF family - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth GNS1_k127_8467204_2 671143.DAMO_2657 8.938e-131 432.0 COG1821@1|root,COG1821@2|Bacteria 2|Bacteria GM Pfam ATP-grasp domain - - 6.3.4.24 ko:K06914 ko00680,map00680 - R10902 RC00090,RC00096 ko00000,ko00001,ko01000 - - - ATP-grasp_3 GNS1_k127_8467204_1 671143.DAMO_2658 1.937e-143 462.0 COG1548@1|root,COG1548@2|Bacteria 2|Bacteria GK Hydantoinase/oxoprolinase - - 2.5.1.131 ko:K07072 ko00680,map00680 - R11040 RC01372,RC03335 ko00000,ko00001,ko01000 - - - Hydantoinase_A GNS1_k127_8467204_4 671143.DAMO_2673 1.79e-87 295.0 COG2054@1|root,COG2054@2|Bacteria 2|Bacteria - - - - 1.13.11.81,2.7.4.31,4.1.2.25,5.1.99.8 ko:K01633,ko:K07144 ko00680,ko00790,ko01100,map00680,map00790,map01100 M00126,M00840 R03504,R11037,R11039,R11073 RC00002,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase GNS1_k127_8467204_3 671143.DAMO_2674 6.845e-90 302.0 COG1891@1|root,COG1891@2|Bacteria 2|Bacteria T lyase activity - - 1.13.11.81,4.1.2.25,4.2.3.153,5.1.99.8 ko:K01633,ko:K09733 ko00680,ko00790,ko01100,map00680,map00790,map01100 M00126,M00840 R03504,R10935,R11037,R11073 RC00721,RC00943,RC01479,RC03315,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - 4HFCP_synth,FolB GNS1_k127_8467204_0 671143.DAMO_0093 5.473e-178 563.0 COG3288@1|root,COG3288@2|Bacteria,2NQF3@2323|unclassified Bacteria 2|Bacteria C Alanine dehydrogenase/PNT, C-terminal domain pntA GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0097159,GO:1901265,GO:1901363 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N GNS1_k127_8467204_8 671143.DAMO_0094 2.622e-23 102.0 COG3288@1|root,COG3288@2|Bacteria,2NRJW@2323|unclassified Bacteria 2|Bacteria C 4TM region of pyridine nucleotide transhydrogenase, mitoch pntA-2 - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM GNS1_k127_8581722_3 671143.DAMO_0414 6.205e-18 83.0 COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria 2|Bacteria T Osmosensitive K+ channel His kinase sensor domain - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,KdpD,Usp GNS1_k127_8581722_0 671143.DAMO_0415 3.855e-111 366.0 COG0745@1|root,COG0745@2|Bacteria,2NQWD@2323|unclassified Bacteria 2|Bacteria T Transcriptional regulatory protein, C terminal - - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C GNS1_k127_8581722_1 1380355.JNIJ01000001_gene4036 8.11e-60 216.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,3JRS0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.1.1.41,4.2.1.17 ko:K01692,ko:K11264 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 GNS1_k127_8581722_2 671143.DAMO_1037 1.092e-40 151.0 COG1135@1|root,COG1135@2|Bacteria 2|Bacteria P methionine transport - - - ko:K02071 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - Fer4,NIL GNS1_k127_858184_1 1125863.JAFN01000001_gene622 1.629e-77 280.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,42M2D@68525|delta/epsilon subdivisions,2WJU6@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lipopolysaccharide biosynthesis protein wzc1 - - - - - - - - - - - GNVR,Wzz GNS1_k127_858184_4 1242864.D187_010007 1.099e-39 154.0 COG1596@1|root,COG1596@2|Bacteria,1N6I6@1224|Proteobacteria,42UGK@68525|delta/epsilon subdivisions,2WQTF@28221|Deltaproteobacteria,2YVVS@29|Myxococcales 28221|Deltaproteobacteria M Polysaccharide biosynthesis/export protein - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB GNS1_k127_858184_3 671143.DAMO_0191 1.533e-48 179.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - GerE,Response_reg GNS1_k127_858184_2 671143.DAMO_0189 2.403e-68 241.0 COG2197@1|root,COG2197@2|Bacteria,2NPMZ@2323|unclassified Bacteria 2|Bacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg GNS1_k127_858184_0 1283284.AZUK01000001_gene2452 5.59e-122 404.0 COG1361@1|root,COG1361@2|Bacteria,1MUQC@1224|Proteobacteria,1RYHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PFAM Peptidase M11 gametolysin - - - - - - - - - - - - NPCBM_assoc,Peptidase_M11 GNS1_k127_8643282_2 247490.KSU1_D0755 3.977e-32 134.0 COG0546@1|root,COG0546@2|Bacteria,2J0RU@203682|Planctomycetes 203682|Planctomycetes S HAD-hyrolase-like - - - - - - - - - - - - HAD_2 GNS1_k127_8643282_0 671143.DAMO_0948 2.376e-176 559.0 COG0477@1|root,COG2814@2|Bacteria,2NQYI@2323|unclassified Bacteria 2|Bacteria EGP Sugar (and other) transporter yajR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,Sugar_tr GNS1_k127_8643282_1 909663.KI867150_gene2225 8.052e-50 187.0 COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,42SE8@68525|delta/epsilon subdivisions,2X5UM@28221|Deltaproteobacteria,2MSJM@213462|Syntrophobacterales 28221|Deltaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 GNS1_k127_8643282_4 1304284.L21TH_1681 1.133e-10 63.0 COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,36N2I@31979|Clostridiaceae 186801|Clostridia O glutaredoxin-like protein, YruB-family - - - - - - - - - - - - Glutaredoxin GNS1_k127_8653167_5 671143.DAMO_0470 1.203e-57 205.0 COG1907@1|root,COG1907@2|Bacteria 2|Bacteria S transferase activity, transferring glycosyl groups mptG - 2.4.2.54 ko:K06984 ko00790,map00790 - R10337,R11102 - ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N GNS1_k127_8653167_4 671143.DAMO_0471 4.67e-82 276.0 COG2457@1|root,COG2457@2|Bacteria 2|Bacteria S Protein of unknown function (DUF447) - - - ko:K09154 - - - - ko00000 - - - DUF447 GNS1_k127_8653167_6 1123508.JH636440_gene2198 1.984e-35 147.0 COG2441@1|root,COG2441@2|Bacteria,2IYYM@203682|Planctomycetes 203682|Planctomycetes C Protein of unknown function (DUF1464) - - - - - - - - - - - - DUF1464 GNS1_k127_8653167_1 671143.DAMO_0472 5.136e-240 747.0 COG0294@1|root,COG0294@2|Bacteria 2|Bacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives - - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind GNS1_k127_8653167_3 671143.DAMO_0473 1.032e-114 376.0 COG1028@1|root,COG1028@2|Bacteria,2NPQY@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GNS1_k127_8653167_2 671143.DAMO_0474 4.209e-166 530.0 COG0502@1|root,COG0502@2|Bacteria 2|Bacteria H biotin synthase activity bioB - 2.6.1.62,2.8.1.6 ko:K00833,ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078,R03231 RC00006,RC00441,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iAF987.Gmet_1582,iJN678.bioB BATS,Radical_SAM GNS1_k127_8653167_0 671143.DAMO_0475 1.554e-248 778.0 COG0161@1|root,COG0161@2|Bacteria,2NQY4@2323|unclassified Bacteria 2|Bacteria H Aminotransferase class-III bioA - 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iSB619.SA_RS12705 Aminotran_3 GNS1_k127_8653167_7 671143.DAMO_0476 4.551e-08 55.0 COG0132@1|root,COG0132@2|Bacteria 2|Bacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 ko:K00652,ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182,R03210,R10124 RC00004,RC00039,RC00868,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - AAA_26 GNS1_k127_8683006_0 526225.Gobs_2424 8.528e-249 781.0 COG0332@1|root,COG0332@2|Bacteria,2IAG3@201174|Actinobacteria,4EUGQ@85013|Frankiales 201174|Actinobacteria I PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III domain protein - - - - - - - - - - - - ACP_syn_III,ACP_syn_III_C GNS1_k127_8683006_2 266117.Rxyl_2385 2.104e-101 341.0 COG3243@1|root,COG3243@2|Bacteria,2GP7I@201174|Actinobacteria,4CQCE@84995|Rubrobacteria 84995|Rubrobacteria I Alpha beta hydrolase - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - AMP-binding,Abhydrolase_1 GNS1_k127_8683006_5 1038862.KB893895_gene7156 0.0003324 50.0 2DSEU@1|root,33FV9@2|Bacteria,1RG4E@1224|Proteobacteria,2U66H@28211|Alphaproteobacteria,3JYBR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S polyhydroxyalkanoic acid synthase, PhaR subunit - - - - - - - - - - - - PHA_synth_III_E GNS1_k127_8683006_3 667014.Thein_0375 6.798e-79 271.0 COG1028@1|root,COG1028@2|Bacteria,2GH4K@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GNS1_k127_8683006_1 671143.DAMO_3130 3.221e-114 374.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity yacD - 5.2.1.8 ko:K03770,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 GNS1_k127_8720861_0 1303518.CCALI_00450 2.394e-116 378.0 COG1483@1|root,COG1483@2|Bacteria 2|Bacteria C ATPase (AAA superfamily - - - ko:K06922 - - - - ko00000 - - - DUF499 GNS1_k127_8720861_4 1123276.KB893257_gene2857 7.097e-14 73.0 COG5428@1|root,COG5428@2|Bacteria 2|Bacteria S Protein of unknown function (DUF2283) - - - - - - - - - - - - DUF2283 GNS1_k127_8720861_3 383372.Rcas_0270 1.034e-17 86.0 COG5428@1|root,COG5428@2|Bacteria,2G9DH@200795|Chloroflexi 200795|Chloroflexi S Protein of unknown function (DUF2283) - - - - - - - - - - - - DUF2283 GNS1_k127_8720861_2 383372.Rcas_0271 5.968e-21 95.0 2E9PK@1|root,333W0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4258 GNS1_k127_8720861_1 477974.Daud_0506 5.706e-94 314.0 COG1743@1|root,COG1743@2|Bacteria,1TRIT@1239|Firmicutes,24AVX@186801|Clostridia,262DB@186807|Peptococcaceae 186801|Clostridia L DNA methylase - - - ko:K07445 - - - - ko00000 - - - DUF1156 GNS1_k127_8723121_2 671143.DAMO_1215 7.155e-62 216.0 COG0524@1|root,COG0524@2|Bacteria,2NP1T@2323|unclassified Bacteria 2|Bacteria G pfkB family carbohydrate kinase adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 - R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - iAF987.Gmet_2683 PfkB GNS1_k127_8723121_1 671143.DAMO_1214 3.651e-152 485.0 COG0005@1|root,COG0005@2|Bacteria,2NNYQ@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2684 PNP_UDP_1 GNS1_k127_8723121_0 671143.DAMO_1213 1.441e-197 624.0 COG0621@1|root,COG0621@2|Bacteria,2NP2U@2323|unclassified Bacteria 2|Bacteria J Uncharacterized protein family UPF0004 yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 GNS1_k127_8723121_3 1128421.JAGA01000002_gene1681 4.738e-59 208.0 COG3359@1|root,COG3359@2|Bacteria,2NR6M@2323|unclassified Bacteria 2|Bacteria L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 GNS1_k127_8723121_4 671143.DAMO_1210 5.462e-14 73.0 COG0012@1|root,COG0012@2|Bacteria,2NNNF@2323|unclassified Bacteria 2|Bacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C GNS1_k127_8779113_3 671143.DAMO_2605 1.077e-09 60.0 COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria 2|Bacteria S MMPL family hpnN - - ko:K07003 - - - - ko00000 - - - MMPL GNS1_k127_8779113_2 266117.Rxyl_2442 8.083e-21 103.0 COG1547@1|root,COG1547@2|Bacteria 2|Bacteria S Domain of unknown function (DUF309) ypuF - - ko:K09763 - - - - ko00000 - - - DUF309 GNS1_k127_8779113_0 671143.DAMO_2604 3.597e-289 898.0 COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria 2|Bacteria IQ COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C GNS1_k127_8779113_1 247490.KSU1_D0399 5.209e-37 146.0 COG2095@1|root,COG2095@2|Bacteria,2J0YY@203682|Planctomycetes 203682|Planctomycetes U MarC family integral membrane protein - - - - - - - - - - - - MarC GNS1_k127_8808457_3 439235.Dalk_3804 1.478e-93 310.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NI5@68525|delta/epsilon subdivisions,2WIN8@28221|Deltaproteobacteria,2MPXX@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C GNS1_k127_8808457_0 706587.Desti_2892 6.626e-295 917.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding GNS1_k127_8808457_1 706587.Desti_2891 7.4e-134 432.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,42PNV@68525|delta/epsilon subdivisions,2WJVJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 GNS1_k127_8808457_2 439235.Dalk_3801 1.02e-94 316.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MTH@68525|delta/epsilon subdivisions,2WJQY@28221|Deltaproteobacteria,2MK6I@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM inner-membrane translocator - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 GNS1_k127_8853432_7 671143.DAMO_1512 1.478e-46 169.0 COG1562@1|root,COG1562@2|Bacteria,2NQ19@2323|unclassified Bacteria 2|Bacteria I Squalene/phytoene synthase crtB - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY GNS1_k127_8853432_1 671143.DAMO_1513 1.663e-84 285.0 COG3415@1|root,COG3415@2|Bacteria,2NPY9@2323|unclassified Bacteria 2|Bacteria L Protein of unknown function (DUF3105) - - - - - - - - - - - - DDE_Tnp_ISAZ013,DUF3105,HTH_Tnp_IS630 GNS1_k127_8853432_6 1125863.JAFN01000001_gene2762 1.279e-50 186.0 COG0235@1|root,COG0235@2|Bacteria,1N84G@1224|Proteobacteria,42RVW@68525|delta/epsilon subdivisions,2WSI5@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM Class II aldolase - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II GNS1_k127_8853432_2 1121468.AUBR01000019_gene2638 4.481e-71 246.0 COG0123@1|root,COG0123@2|Bacteria,1VX2J@1239|Firmicutes,251VB@186801|Clostridia 186801|Clostridia BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl GNS1_k127_8853432_9 1121468.AUBR01000019_gene2638 2.505e-20 92.0 COG0123@1|root,COG0123@2|Bacteria,1VX2J@1239|Firmicutes,251VB@186801|Clostridia 186801|Clostridia BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl GNS1_k127_8853432_4 671143.DAMO_1515 3.176e-54 195.0 COG1246@1|root,COG1246@2|Bacteria,2NRHE@2323|unclassified Bacteria 2|Bacteria E Acetyltransferase (GNAT) domain argH GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K00619,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0946 ASL_C2,Acetyltransf_1,Lyase_1 GNS1_k127_8853432_0 671143.DAMO_1516 2.579e-155 497.0 COG0430@1|root,COG0430@2|Bacteria,2NP9K@2323|unclassified Bacteria 2|Bacteria A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert GNS1_k127_8853432_8 401526.TcarDRAFT_0927 8.783e-24 108.0 COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,4H5M5@909932|Negativicutes 909932|Negativicutes S Thioesterase family - - - - - - - - - - - - 4HBT GNS1_k127_8853432_5 671143.DAMO_1518 1.189e-52 190.0 COG5496@1|root,COG5496@2|Bacteria,2NQ33@2323|unclassified Bacteria 2|Bacteria S Thioesterase superfamily - - - - - - - - - - - - 4HBT GNS1_k127_8853432_3 1210884.HG799469_gene14128 2.33e-65 228.0 COG4325@1|root,COG4325@2|Bacteria,2IZ4R@203682|Planctomycetes 203682|Planctomycetes S Predicted membrane protein (DUF2254) - - - - - - - - - - - - DUF2254 GNS1_k127_8863354_8 765911.Thivi_2220 3.384e-23 102.0 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,1X2HD@135613|Chromatiales 135613|Chromatiales S MazG-like family - - - - - - - - - - - - MazG-like GNS1_k127_8863354_3 485915.Dret_1547 6.694e-70 242.0 COG3440@1|root,COG3440@2|Bacteria,1N417@1224|Proteobacteria,4378W@68525|delta/epsilon subdivisions,2WUBN@28221|Deltaproteobacteria,2MFP2@213115|Desulfovibrionales 28221|Deltaproteobacteria L HNH endonuclease - - - - - - - - - - - - HNH_2 GNS1_k127_8863354_6 1297570.MESS4_p20069 1.307e-30 123.0 COG3440@1|root,COG3440@2|Bacteria,1QMZK@1224|Proteobacteria,2U542@28211|Alphaproteobacteria 28211|Alphaproteobacteria L HNH endonuclease - - - ko:K07454 - - - - ko00000 - - - HNH_2 GNS1_k127_8863354_1 1121033.AUCF01000001_gene2030 4.549e-116 381.0 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,2JRZ1@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA GNS1_k127_8863354_7 1223523.H340_07813 1.841e-30 129.0 COG2890@1|root,COG2890@2|Bacteria,2IIBT@201174|Actinobacteria 201174|Actinobacteria J Methyltransferase prmC_1 - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS GNS1_k127_8863354_5 292459.STH2449 7.027e-50 186.0 COG3394@1|root,COG3394@2|Bacteria,1V3MB@1239|Firmicutes,24IMA@186801|Clostridia 186801|Clostridia G Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides celG - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC GNS1_k127_8863354_4 861299.J421_3753 7.367e-56 207.0 COG1940@1|root,COG1940@2|Bacteria,1ZT66@142182|Gemmatimonadetes 142182|Gemmatimonadetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK GNS1_k127_8863354_9 1366050.N234_30155 2.003e-22 99.0 COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2W3I9@28216|Betaproteobacteria,1KGBE@119060|Burkholderiaceae 28216|Betaproteobacteria S GYD domain - - - - - - - - - - - - GYD GNS1_k127_8863354_0 671143.DAMO_2995 1.121e-172 546.0 COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria 2|Bacteria S Alcohol dehydrogenase GroES-like domain adhA - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N GNS1_k127_8863354_2 247490.KSU1_C1314 7.797e-115 382.0 COG0535@1|root,COG0535@2|Bacteria,2J2KS@203682|Planctomycetes 203682|Planctomycetes S Proto-chlorophyllide reductase 57 kD subunit - - - - - - - - - - - - PCP_red,Radical_SAM,SPASM GNS1_k127_9010103_1 671143.DAMO_2987 7.671e-44 162.0 COG0124@1|root,COG0124@2|Bacteria,2NNZ7@2323|unclassified Bacteria 2|Bacteria J Histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His GNS1_k127_9010103_0 671143.DAMO_2988 2.835e-313 968.0 COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria 2|Bacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon GNS1_k127_9065255_6 331113.SNE_A11570 2.274e-47 178.0 COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2JGIP@204428|Chlamydiae 204428|Chlamydiae E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GNS1_k127_9065255_10 1382306.JNIM01000001_gene2859 2.824e-16 88.0 COG0589@1|root,COG0589@2|Bacteria,2G7D7@200795|Chloroflexi 200795|Chloroflexi T Universal stress protein family - - - - - - - - - - - - Usp GNS1_k127_9065255_7 632518.Calow_0180 6.69e-33 133.0 COG0569@1|root,COG0569@2|Bacteria,1V2ZF@1239|Firmicutes,24GNX@186801|Clostridia,42H6T@68295|Thermoanaerobacterales 186801|Clostridia C PFAM TrkA-N domain protein trkA2 - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_N GNS1_k127_9065255_5 1303518.CCALI_02918 1.335e-59 213.0 COG0569@1|root,COG0569@2|Bacteria 2|Bacteria P domain protein trkA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N GNS1_k127_9065255_11 243231.GSU0022 5.101e-13 76.0 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatB - - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 GNS1_k127_9065255_0 671143.DAMO_1098 1.659e-133 431.0 COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria 2|Bacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC GNS1_k127_9065255_2 378806.STAUR_6911 6.679e-92 321.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,2YUZ0@29|Myxococcales 28221|Deltaproteobacteria FP Ppx/GppA phosphatase family gppA-2 - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA GNS1_k127_9065255_9 1183438.GKIL_4365 4.803e-21 105.0 COG1437@1|root,COG5607@1|root,COG1437@2|Bacteria,COG5607@2|Bacteria,1G1T8@1117|Cyanobacteria 1117|Cyanobacteria F PFAM CHAD domain - - - - - - - - - - - - CHAD GNS1_k127_9065255_8 1173028.ANKO01000075_gene2953 6.099e-26 114.0 COG2062@1|root,COG2062@2|Bacteria,1G6QD@1117|Cyanobacteria,1HBRK@1150|Oscillatoriales 1117|Cyanobacteria T Phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 GNS1_k127_9065255_4 485913.Krac_9227 3.256e-79 271.0 COG0125@1|root,COG0125@2|Bacteria 2|Bacteria F dTDP biosynthetic process tmk GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.9,4.1.1.19 ko:K00943,ko:K01585 ko00240,ko00330,ko01100,map00240,map00330,map01100 M00053,M00133 R00566,R02094,R02098 RC00002,RC00299 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c AAA_33,Thymidylate_kin GNS1_k127_9065255_1 485913.Krac_9228 4.057e-97 323.0 COG0125@1|root,COG0125@2|Bacteria 2|Bacteria F dTDP biosynthetic process tmk GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 ko:K00560,ko:K00943,ko:K01585 ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523 M00053,M00133 R00566,R02094,R02098,R02101 RC00002,RC00219,RC00299,RC00332 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c AAA_33,Thymidylate_kin GNS1_k127_9065255_3 483219.LILAB_13910 5.068e-86 292.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,2YVGU@29|Myxococcales 28221|Deltaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA GNS1_k127_9065255_12 671143.DAMO_1099 9.698e-10 59.0 COG0704@1|root,COG1392@1|root,COG0704@2|Bacteria,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria 2|Bacteria P Protein of unknown function DUF47 phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039,ko:K07220 - - - - ko00000 - - - PhoU,PhoU_div GNS1_k127_9136123_5 671143.DAMO_0577 4.863e-32 128.0 COG0613@1|root,COG0613@2|Bacteria,2NPEX@2323|unclassified Bacteria 2|Bacteria S DNA polymerase alpha chain like domain trpH - 3.1.3.97,4.1.2.13 ko:K01624,ko:K07053 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R00188,R01068,R01070,R01829,R02568,R11188 RC00078,RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - PHP GNS1_k127_9136123_4 671143.DAMO_0576 2.371e-41 155.0 COG0858@1|root,COG0858@2|Bacteria,2NQ7B@2323|unclassified Bacteria 2|Bacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K02834 - - - - ko00000,ko03009 - - - RBFA GNS1_k127_9136123_3 671143.DAMO_0575 2.639e-44 162.0 COG1550@1|root,COG1550@2|Bacteria,2NPYX@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF503) ylxP - - ko:K09764 - - - - ko00000 - - - DUF503 GNS1_k127_9136123_0 671143.DAMO_0574 0.0 1043.0 COG0532@1|root,COG0532@2|Bacteria,2NNRG@2323|unclassified Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N GNS1_k127_9136123_2 671143.DAMO_0572 3.133e-56 203.0 COG1358@1|root,COG1358@2|Bacteria 2|Bacteria J ncRNA processing ylxRQ - - ko:K07590,ko:K07742 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - DUF448,Ribosomal_L7Ae GNS1_k127_9136123_1 671143.DAMO_0571 1.792e-200 632.0 COG0195@1|root,COG0195@2|Bacteria,2NNV1@2323|unclassified Bacteria 2|Bacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 GNS1_k127_9136123_6 671143.DAMO_0569 1.876e-12 67.0 COG0779@1|root,COG0779@2|Bacteria,2NPVA@2323|unclassified Bacteria 2|Bacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C GNS1_k127_9290098_1 671143.DAMO_2907 7.063e-171 542.0 COG3842@1|root,COG3842@2|Bacteria,2NPAF@2323|unclassified Bacteria 2|Bacteria E ATPases associated with a variety of cellular activities potA - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 GNS1_k127_9290098_3 633.DJ40_375 1.161e-45 171.0 COG3470@1|root,COG3470@2|Bacteria,1RA2Z@1224|Proteobacteria,1RS32@1236|Gammaproteobacteria,41D8I@629|Yersinia 1236|Gammaproteobacteria P to PERIPLASMIC PROTEIN-probably involved in high-affinity Fe2 transport of Bacteria UniRef RepID Q7M8L6_WOLSU tpd - - ko:K07230 - - - - ko00000,ko02000 2.A.108.2.10,2.A.108.2.4,2.A.108.2.9 - - Iron_transport GNS1_k127_9290098_2 671143.DAMO_2905 4.923e-167 532.0 COG1477@1|root,COG1477@2|Bacteria,2NPJE@2323|unclassified Bacteria 2|Bacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein nosX - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE GNS1_k127_9290098_0 671143.DAMO_2904 4.565e-188 597.0 COG2433@1|root,COG2433@2|Bacteria 2|Bacteria - - - - - ko:K12065 - - - - ko00000,ko02044 3.A.7.11.1 - - Porin_O_P GNS1_k127_9296021_4 344747.PM8797T_05960 1.1e-09 59.0 COG0677@1|root,COG0677@2|Bacteria,2IXVX@203682|Planctomycetes 203682|Planctomycetes M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N GNS1_k127_9296021_2 1128421.JAGA01000003_gene2785 1.127e-72 259.0 COG0472@1|root,COG0472@2|Bacteria,2NR03@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferase family 4 - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - CoA_binding_3,Glycos_transf_4 GNS1_k127_9296021_1 671143.DAMO_1083 3.983e-82 284.0 COG0424@1|root,COG0424@2|Bacteria,2NPJA@2323|unclassified Bacteria 2|Bacteria D Maf-like protein maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 ko:K00014,ko:K03215,ko:K06287 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000,ko03009 - - - Maf GNS1_k127_9296021_0 671143.DAMO_1091 7.275e-96 317.0 COG0163@1|root,COG0163@2|Bacteria,2NR4A@2323|unclassified Bacteria 2|Bacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein GNS1_k127_9329457_2 671143.DAMO_0756 4.549e-78 265.0 COG0477@1|root,COG2814@2|Bacteria,2NRCB@2323|unclassified Bacteria 2|Bacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,Sugar_tr GNS1_k127_9329457_3 671143.DAMO_0755 1.198e-32 129.0 COG1522@1|root,COG1522@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - AsnC_trans_reg GNS1_k127_9329457_0 671143.DAMO_0754 3.586e-245 765.0 COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria 2|Bacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N GNS1_k127_9329457_1 671143.DAMO_0753 3.471e-78 261.0 COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria 2|Bacteria O Pup-ligase protein pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase GNS1_k127_9338230_3 671143.DAMO_1125 4.376e-44 162.0 COG0640@1|root,COG0640@2|Bacteria,2NQ4D@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor arsR - - ko:K03892,ko:K21903 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 GNS1_k127_9338230_1 234267.Acid_4410 1.507e-120 392.0 COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria 57723|Acidobacteria Q Hypothetical methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 GNS1_k127_9338230_0 671143.DAMO_1124 2.491e-192 608.0 COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria 2|Bacteria P Sodium Bile acid symporter family arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF GNS1_k127_9338230_2 671143.DAMO_1123 3.357e-63 220.0 COG0394@1|root,COG0394@2|Bacteria,2NPGV@2323|unclassified Bacteria 2|Bacteria T Low molecular weight phosphatase family arsC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc GNS1_k127_9347612_1 671143.DAMO_1250 1.287e-187 591.0 COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47,6.2.1.14 ko:K00639,ko:K00652,ko:K01906 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03209,R03210,R10124 RC00004,RC00014,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 GNS1_k127_9347612_0 671143.DAMO_1249 0.0 1176.0 COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria 2|Bacteria S Uncharacterised protein family (UPF0182) - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K09118 - - - - ko00000 - - - UPF0182 GNS1_k127_93574_5 671143.DAMO_2315 7.435e-123 398.0 COG0289@1|root,COG0289@2|Bacteria,2NPX5@2323|unclassified Bacteria 2|Bacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215,ko:K03546 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000,ko03400 - - iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035 DapB_C,DapB_N GNS1_k127_93574_2 671143.DAMO_2314 5.078e-139 445.0 COG0179@1|root,COG0179@2|Bacteria,2NP4G@2323|unclassified Bacteria 2|Bacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - DUF2437,FAA_hydrolase GNS1_k127_93574_0 671143.DAMO_2313 1.769e-217 680.0 COG0436@1|root,COG0436@2|Bacteria,2NQG2@2323|unclassified Bacteria 2|Bacteria E Aminotransferase class I and II dapL - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 GNS1_k127_93574_10 1123252.ATZF01000011_gene3154 2.255e-31 126.0 COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4HKKK@91061|Bacilli,27C6J@186824|Thermoactinomycetaceae 91061|Bacilli H Dihydroneopterin aldolase folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB GNS1_k127_93574_8 671143.DAMO_2312 1.799e-57 208.0 COG0801@1|root,COG0801@2|Bacteria,2NPPF@2323|unclassified Bacteria 2|Bacteria H 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK - 1.13.11.81,2.5.1.15,2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25,5.1.99.8 ko:K00796,ko:K00950,ko:K01495,ko:K01633,ko:K13940,ko:K17488 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841,M00842,M00843 R00428,R03066,R03067,R03503,R03504,R04639,R05046,R05048,R10348,R11037,R11073 RC00002,RC00017,RC00121,RC00263,RC00294,RC00323,RC00721,RC00842,RC00943,RC00945,RC01188,RC01479,RC02504,RC03131,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0041 FolB,HPPK GNS1_k127_93574_6 671143.DAMO_2311 5.183e-115 372.0 COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria 2|Bacteria F Deoxynucleoside kinase dgk - 2.7.1.113 ko:K15518 ko00230,map00230 - R01967 RC00002,RC00017 ko00000,ko00001,ko01000 - - - HPPK,dNK GNS1_k127_93574_1 671143.DAMO_2310 3.243e-143 460.0 COG0413@1|root,COG0413@2|Bacteria,2NP1G@2323|unclassified Bacteria 2|Bacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf GNS1_k127_93574_4 671143.DAMO_2309 1.221e-123 404.0 COG0414@1|root,COG0414@2|Bacteria,2NP0J@2323|unclassified Bacteria 2|Bacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25,6.3.2.1 ko:K01918,ko:K13799 ko00240,ko00410,ko00770,ko01100,ko01110,map00240,map00410,map00770,map01100,map01110 M00052,M00119 R00158,R00512,R01665,R02473 RC00002,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin,Pantoate_ligase GNS1_k127_93574_7 671143.DAMO_2308 1.247e-79 267.0 COG2001@1|root,COG2001@2|Bacteria,2NPTY@2323|unclassified Bacteria 2|Bacteria K MraZ protein, putative antitoxin-like mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ GNS1_k127_93574_11 445975.COLSTE_02484 2.767e-05 51.0 COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2HUNT@201174|Actinobacteria,4CV8A@84998|Coriobacteriia 84998|Coriobacteriia T Belongs to the anti-sigma-factor antagonist family - - - - - - - - - - - - HATPase_c_2,STAS,STAS_2 GNS1_k127_93574_3 671143.DAMO_2307 1.119e-129 425.0 COG0275@1|root,COG0275@2|Bacteria,2NP8Y@2323|unclassified Bacteria 2|Bacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 GNS1_k127_93574_9 671143.DAMO_2306 9.049e-32 126.0 2DT1T@1|root,33IAD@2|Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - FtsL GNS1_k127_943990_1 671143.DAMO_0098 1.768e-57 211.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec GNS1_k127_943990_0 251221.35210840 2.197e-129 441.0 COG1629@1|root,COG4771@2|Bacteria,1G3RJ@1117|Cyanobacteria 1117|Cyanobacteria P TIGRFAM TonB-dependent heme hemoglobin receptor family protein - - - ko:K02014,ko:K16087 - - - - ko00000,ko02000 1.B.14,1.B.14.2 - - AMIN,Plug,TonB_dep_Rec GNS1_k127_943990_2 96561.Dole_1195 1.891e-14 81.0 COG1462@1|root,COG1462@2|Bacteria,1QRM1@1224|Proteobacteria,43A0T@68525|delta/epsilon subdivisions,2X2Q5@28221|Deltaproteobacteria,2MMD7@213118|Desulfobacterales 28221|Deltaproteobacteria M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG GNS1_k127_946902_17 387631.Asulf_01120 2.429e-08 57.0 COG0546@1|root,arCOG02292@2157|Archaea,2XZX6@28890|Euryarchaeota,246FI@183980|Archaeoglobi 183980|Archaeoglobi S haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - - - - - - - - - - - HAD_2 GNS1_k127_946902_8 671143.DAMO_0949 2.764e-94 315.0 COG2045@1|root,COG2045@2|Bacteria,2NPF1@2323|unclassified Bacteria 2|Bacteria H Belongs to the ComB family comB GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp GNS1_k127_946902_1 671143.DAMO_2120 0.0 1075.0 COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria 2|Bacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg GNS1_k127_946902_0 671143.DAMO_2121 0.0 1139.0 COG0635@1|root,COG2267@1|root,COG0635@2|Bacteria,COG2267@2|Bacteria,2NRGT@2323|unclassified Bacteria 2|Bacteria H Elongator protein 3, MiaB family, Radical SAM estX - - - - - - - - - - - Abhydrolase_1,Hydrolase_4,Radical_SAM GNS1_k127_946902_5 671143.DAMO_2122 9.591e-141 454.0 COG2107@1|root,COG2107@2|Bacteria,2NQC0@2323|unclassified Bacteria 2|Bacteria S Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K07083,ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth GNS1_k127_946902_7 330214.NIDE3081 2.833e-97 323.0 COG3253@1|root,COG3253@2|Bacteria 2|Bacteria S peroxidase activity - - - - - - - - - - - - Chlor_dismutase GNS1_k127_946902_13 671143.DAMO_2124 3.953e-33 130.0 COG0828@1|root,COG0828@2|Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 GNS1_k127_946902_11 671143.DAMO_2125 1.149e-49 179.0 COG0724@1|root,COG0724@2|Bacteria,2NPT0@2323|unclassified Bacteria 2|Bacteria S RNA recognition motif rbpD - - - - - - - - - - - RRM_1 GNS1_k127_946902_4 671143.DAMO_2127 2.162e-152 489.0 COG0628@1|root,COG0628@2|Bacteria 2|Bacteria D permease - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - AI-2E_transport GNS1_k127_946902_6 671143.DAMO_2128 6.971e-125 407.0 COG1446@1|root,COG1446@2|Bacteria,2NPFC@2323|unclassified Bacteria 2|Bacteria E Asparaginase - - 3.4.19.5,3.5.1.1,3.5.1.26 ko:K01424,ko:K01444,ko:K13051 ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2 GNS1_k127_946902_10 264732.Moth_1998 1.917e-79 280.0 COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia,42J3Q@68295|Thermoanaerobacterales 186801|Clostridia E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP GNS1_k127_946902_12 296591.Bpro_2056 2.157e-38 157.0 COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity cpeZ - - ko:K05384,ko:K05386 ko00196,ko01100,map00196,map01100 - - - ko00000,ko00001,ko00194 - - - HEAT_2 GNS1_k127_946902_3 671143.DAMO_2129 1.166e-183 586.0 COG0501@1|root,COG0501@2|Bacteria,2NP9X@2323|unclassified Bacteria 2|Bacteria O CAAX prenyl protease N-terminal, five membrane helices agmM - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N GNS1_k127_946902_9 671143.DAMO_2130 2.429e-87 289.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis sscB - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 GNS1_k127_946902_14 118168.MC7420_487 7.341e-24 103.0 2DGIJ@1|root,2ZW4N@2|Bacteria,1GH3J@1117|Cyanobacteria,1HH1C@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - GNS1_k127_946902_16 1499967.BAYZ01000016_gene6498 7.812e-17 84.0 2E3CI@1|root,32YBU@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - ParE_toxin GNS1_k127_946902_15 1112217.PPL19_22769 6.648e-19 93.0 COG2761@1|root,COG2761@2|Bacteria,1RIE0@1224|Proteobacteria 1224|Proteobacteria Q DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA GNS1_k127_946902_2 671143.DAMO_2134 2.059e-294 910.0 COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria 2|Bacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 2.7.7.7,6.5.1.2 ko:K01972,ko:K02342,ko:K04096,ko:K12472 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,ko04144,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440,map04144 M00260 R00375,R00376,R00377,R00378,R00382 RC00005,RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400,ko04131 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5,RNase_T GNS1_k127_982235_6 671143.DAMO_0677 1.825e-68 237.0 COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 GNS1_k127_982235_0 671143.DAMO_0676 2.52e-226 713.0 COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria 2|Bacteria M Carbon-nitrogen hydrolase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase GNS1_k127_982235_3 671143.DAMO_0675 1.352e-121 397.0 COG4589@1|root,COG4589@2|Bacteria,2NPVB@2323|unclassified Bacteria 2|Bacteria S Belongs to the CDS family cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 GNS1_k127_982235_5 671143.DAMO_0674 5.1e-83 278.0 COG0233@1|root,COG0233@2|Bacteria,2NPEP@2323|unclassified Bacteria 2|Bacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF GNS1_k127_982235_1 671143.DAMO_0673 3.204e-126 407.0 COG0528@1|root,COG0528@2|Bacteria,2NNRY@2323|unclassified Bacteria 2|Bacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - iSB619.SA_RS06240 AA_kinase GNS1_k127_982235_4 671143.DAMO_0672 5.578e-98 326.0 COG0264@1|root,COG0264@2|Bacteria,2NP3B@2323|unclassified Bacteria 2|Bacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS GNS1_k127_982235_2 671143.DAMO_0671 1.24e-124 403.0 COG0052@1|root,COG0052@2|Bacteria,2NP4M@2323|unclassified Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 ## 1478 queries scanned ## Total time (seconds): 312.40970969200134 ## Rate: 4.73 q/s