## Fri Nov 15 02:24:52 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin6/GNS_2_bin.19.fa -m mmseqs --itype genome -o GNS_2_bin.19 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/GNS_2_bin.19 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
GNS2_k127_1075563_2	555079.Toce_2104	8.676e-67	233.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,42FYD@68295|Thermoanaerobacterales	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
GNS2_k127_1075563_3	994573.T472_0212600	2.357e-56	199.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,36I00@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
GNS2_k127_1075563_0	390874.Tpet_0344	1.989e-105	354.0	COG0809@1|root,COG0809@2|Bacteria,2GBXV@200918|Thermotogae	200918|Thermotogae	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
GNS2_k127_1075563_6	1122216.AUHW01000010_gene1311	1.059e-34	143.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4H20Z@909932|Negativicutes	909932|Negativicutes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
GNS2_k127_1075563_5	391612.CY0110_09465	8.166e-36	145.0	COG1208@1|root,COG1208@2|Bacteria,1G128@1117|Cyanobacteria,3KHCK@43988|Cyanothece	1117|Cyanobacteria	M	Nucleotidyl transferase	-	-	2.7.7.71	ko:K15669	ko00540,map00540	-	R09772	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
GNS2_k127_1075563_9	1157490.EL26_18910	2.417e-10	68.0	COG0671@1|root,COG0671@2|Bacteria,1VARM@1239|Firmicutes,4HN1F@91061|Bacilli,27A57@186823|Alicyclobacillaceae	91061|Bacilli	I	Acid phosphatase homologues	bcrC	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
GNS2_k127_1075563_4	1140002.I570_03853	9.715e-44	173.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,4AZHR@81852|Enterococcaceae	91061|Bacilli	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
GNS2_k127_1075563_7	457396.CSBG_01823	8.641e-29	123.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,36EVE@31979|Clostridiaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
GNS2_k127_1075563_8	289376.THEYE_A0821	1.517e-20	94.0	COG0335@1|root,COG0335@2|Bacteria,3J0MJ@40117|Nitrospirae	40117|Nitrospirae	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
GNS2_k127_1075563_1	381764.Fnod_1525	2.799e-80	271.0	COG0178@1|root,COG0178@2|Bacteria,2GCER@200918|Thermotogae	200918|Thermotogae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
GNS2_k127_132679_2	1033737.CAEV01000095_gene1584	1.768e-31	123.0	COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,36KI4@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
GNS2_k127_132679_1	1123258.AQXZ01000018_gene580	5.114e-56	199.0	293T3@1|root,2ZR8H@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
GNS2_k127_132679_0	215803.DB30_4254	1.264e-167	543.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,42N4C@68525|delta/epsilon subdivisions,2WJIH@28221|Deltaproteobacteria,2YWDN@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
GNS2_k127_1395797_1	926550.CLDAP_04150	5.084e-55	196.0	COG0048@1|root,COG0048@2|Bacteria,2G6EX@200795|Chloroflexi	200795|Chloroflexi	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
GNS2_k127_1395797_2	1042375.AFPL01000058_gene1453	3.129e-49	180.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,466NR@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
GNS2_k127_1395797_0	246194.CHY_2313	7.635e-303	942.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,42EYD@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
GNS2_k127_1395797_3	1131462.DCF50_p2673	1.477e-08	70.0	COG2247@1|root,COG4733@1|root,COG2247@2|Bacteria,COG4733@2|Bacteria,1UZS5@1239|Firmicutes,24FE6@186801|Clostridia,2600Z@186807|Peptococcaceae	186801|Clostridia	M	cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Endopep_inhib,fn3
GNS2_k127_1507295_10	411459.RUMOBE_02439	8.844e-19	92.0	2DX7X@1|root,32V2Y@2|Bacteria,1VB4V@1239|Firmicutes,254MP@186801|Clostridia,3Y083@572511|Blautia	186801|Clostridia	S	COG NOG38524 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1507295_13	72658.Bostr.14018s0001.1.p	8.585e-08	54.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1507295_14	1150469.RSPPHO_03279	2.018e-06	52.0	2DTV2@1|root,33MS7@2|Bacteria,1NKAB@1224|Proteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1507295_19	204536.SULAZ_1633	0.0003438	43.0	2B9ZZ@1|root,323DM@2|Bacteria	2|Bacteria	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1507295_11	1262914.BN533_00083	3.174e-18	85.0	2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes	1239|Firmicutes	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1507295_6	1123274.KB899431_gene3241	3.037e-42	160.0	2AU0F@1|root,31JKB@2|Bacteria	2|Bacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1507295_16	441769.ABFU01000136_gene3470	2.068e-05	48.0	29XEQ@1|root,30J4Y@2|Bacteria,1U437@1239|Firmicutes,4IDV7@91061|Bacilli,1ZJYP@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1507295_18	1232666.JANE01000082_gene515	0.0003437	49.0	COG3684@1|root,COG3684@2|Bacteria,1TQRR@1239|Firmicutes,4HBS9@91061|Bacilli,4GX3X@90964|Staphylococcaceae	91061|Bacilli	G	Belongs to the aldolase LacD family	lacD	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
GNS2_k127_1507295_12	311424.DhcVS_1127	1.833e-13	76.0	COG3684@1|root,COG3684@2|Bacteria,2G5XK@200795|Chloroflexi,34CKX@301297|Dehalococcoidia	301297|Dehalococcoidia	G	DeoC/LacD family aldolase	-	-	4.1.2.40	ko:K01635	ko00052,ko01100,ko02024,map00052,map01100,map02024	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	DeoC
GNS2_k127_1507295_17	671143.DAMO_2476	3.245e-05	53.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	2.6.1.9,3.1.3.10,3.8.1.2	ko:K00817,ko:K01560,ko:K07025,ko:K20866	ko00010,ko00340,ko00350,ko00360,ko00361,ko00400,ko00401,ko00625,ko00960,ko01100,ko01110,ko01120,ko01130,ko01230,map00010,map00340,map00350,map00360,map00361,map00400,map00401,map00625,map00960,map01100,map01110,map01120,map01130,map01230	M00026	R00694,R00734,R00947,R03243,R05287	RC00006,RC00078,RC00697,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	HAD_2,Hydrolase
GNS2_k127_1507295_5	857293.CAAU_0639	3.592e-45	173.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,36EN8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
GNS2_k127_1507295_0	744872.Spica_2048	1.435e-206	659.0	COG0449@1|root,COG0449@2|Bacteria,2J587@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
GNS2_k127_1507295_8	1487921.DP68_10980	5.123e-33	136.0	COG0637@1|root,COG0637@2|Bacteria,1V1NW@1239|Firmicutes,24G37@186801|Clostridia,36IF1@31979|Clostridiaceae	186801|Clostridia	J	subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,HAD_2
GNS2_k127_1507295_4	1120970.AUBZ01000022_gene1310	2.406e-50	191.0	COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,1RQP9@1236|Gammaproteobacteria,468CT@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Uncharacterised protein family UPF0052	ybhK	-	-	-	-	-	-	-	-	-	-	-	UPF0052
GNS2_k127_1507295_9	368408.Tpen_1068	2.473e-27	114.0	COG0454@1|root,arCOG00826@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
GNS2_k127_1507295_3	224324.aq_1306	6.766e-63	231.0	COG0045@1|root,COG0045@2|Bacteria,2G3SH@200783|Aquificae	200783|Aquificae	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	-	-	6.2.1.18	ko:K15232	ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200	M00173	R01322	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
GNS2_k127_1507295_1	935836.JAEL01000015_gene258	7.732e-69	243.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli,1ZE6J@1386|Bacillus	91061|Bacilli	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,Succ_CoA_lig
GNS2_k127_1507295_2	1158345.JNLL01000001_gene533	1.712e-68	241.0	COG0372@1|root,COG0372@2|Bacteria,2G4GQ@200783|Aquificae	200783|Aquificae	C	Citrate synthase, C-terminal domain	-	-	4.1.3.34	ko:K15234	ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200	M00173	R00354	RC00067,RC00502	ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
GNS2_k127_1507295_7	1122182.KB903815_gene1458	1.961e-33	134.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2I12T@201174|Actinobacteria,4DAIS@85008|Micromonosporales	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	pcrA	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
GNS2_k127_1603855_1	267377.MMP1577	1.161e-118	401.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,23Q36@183939|Methanococci	183939|Methanococci	K	SMART Elongator protein 3 MiaB NifB	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Acetyltransf_10,Radical_SAM,Radical_SAM_C
GNS2_k127_1603855_2	910964.GEAM_4144	4.094e-07	57.0	COG1051@1|root,COG1051@2|Bacteria,1RF2T@1224|Proteobacteria,1S44A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	belongs to the nudix hydrolase family	rppH_2	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
GNS2_k127_1603855_0	1313172.YM304_10550	2.504e-148	481.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4CMSU@84992|Acidimicrobiia	84992|Acidimicrobiia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
GNS2_k127_1603855_3	765952.PUV_14030	1.117e-06	52.0	COG3344@1|root,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
GNS2_k127_1707647_0	589865.DaAHT2_1454	8.785e-186	587.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
GNS2_k127_1707647_18	706434.HMPREF9429_01725	2.586e-35	138.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,4H7MA@909932|Negativicutes	909932|Negativicutes	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
GNS2_k127_1707647_12	765420.OSCT_0199	9.471e-53	197.0	COG0087@1|root,COG0087@2|Bacteria,2G6DQ@200795|Chloroflexi,375C3@32061|Chloroflexia	32061|Chloroflexia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
GNS2_k127_1707647_14	926692.AZYG01000040_gene1594	3.331e-50	185.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,3WAJE@53433|Halanaerobiales	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
GNS2_k127_1707647_26	1449353.JQMQ01000005_gene3644	3.824e-18	91.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,2NJ2T@228398|Streptacidiphilus	201174|Actinobacteria	J	Ribosomal protein L23	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
GNS2_k127_1707647_5	1408324.JNJK01000007_gene3003	1.56e-89	303.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,27J0H@186928|unclassified Lachnospiraceae	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
GNS2_k127_1707647_22	575540.Isop_2083	2.829e-28	117.0	COG0185@1|root,COG0185@2|Bacteria,2J0BB@203682|Planctomycetes	203682|Planctomycetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
GNS2_k127_1707647_20	550540.Fbal_0274	1.525e-29	122.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
GNS2_k127_1707647_10	696281.Desru_0304	2.147e-59	214.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,26103@186807|Peptococcaceae	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
GNS2_k127_1707647_13	644966.Tmar_2288	4.574e-51	184.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3WCGY@538999|Clostridiales incertae sedis	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
GNS2_k127_1707647_30	243272.MARTH_orf434	1.791e-05	49.0	COG0255@1|root,COG0255@2|Bacteria,3WTX6@544448|Tenericutes	544448|Tenericutes	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
GNS2_k127_1707647_27	412419.BDU_490	1.635e-17	85.0	COG0186@1|root,COG0186@2|Bacteria,2J8VM@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
GNS2_k127_1707647_15	373903.Hore_01270	1.069e-46	171.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,3WARB@53433|Halanaerobiales	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
GNS2_k127_1707647_24	351627.Csac_2276	5.39e-24	104.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,42GS5@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
GNS2_k127_1707647_9	665952.HMPREF1015_02853	9.331e-61	214.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,4HBAX@91061|Bacilli,1ZB6T@1386|Bacillus	91061|Bacilli	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
GNS2_k127_1707647_25	649638.Trad_1051	6.122e-21	93.0	COG0199@1|root,COG0199@2|Bacteria,1WKJR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
GNS2_k127_1707647_19	887327.HMPREF0476_1782	4.217e-33	132.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,2KR19@206351|Neisseriales	206351|Neisseriales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
GNS2_k127_1707647_11	926561.KB900620_gene3186	4.299e-54	195.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,3WAMI@53433|Halanaerobiales	186801|Clostridia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
GNS2_k127_1707647_21	2423.NA23_0208125	1.121e-28	119.0	COG0256@1|root,COG0256@2|Bacteria,2GD32@200918|Thermotogae	200918|Thermotogae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
GNS2_k127_1707647_16	1307761.L21SP2_0893	1.907e-37	146.0	COG0098@1|root,COG0098@2|Bacteria,2J60F@203691|Spirochaetes	203691|Spirochaetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
GNS2_k127_1707647_23	639282.DEFDS_1754	7.581e-25	109.0	COG0200@1|root,COG0200@2|Bacteria,2GFM2@200930|Deferribacteres	200930|Deferribacteres	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
GNS2_k127_1707647_3	479434.Sthe_1056	1.118e-119	397.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi,27XI1@189775|Thermomicrobia	189775|Thermomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
GNS2_k127_1707647_17	476272.RUMHYD_02800	5.442e-37	148.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3XZAB@572511|Blautia	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
GNS2_k127_1707647_7	102232.GLO73106DRAFT_00031140	8.131e-70	245.0	COG0024@1|root,COG0024@2|Bacteria,1G0QP@1117|Cyanobacteria	1117|Cyanobacteria	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
GNS2_k127_1707647_28	796945.HMPREF1145_0420	6.932e-14	77.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,2PSD9@265975|Oribacterium	186801|Clostridia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
GNS2_k127_1707647_29	574087.Acear_0680	3.761e-12	74.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,3WAT7@53433|Halanaerobiales	186801|Clostridia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
GNS2_k127_1707647_1	459349.CLOAM0728	6.09e-176	561.0	COG0017@1|root,COG0017@2|Bacteria,2NNQM@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class II (D, K and N)	asnS	GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
GNS2_k127_1707647_6	1123368.AUIS01000021_gene991	8.879e-85	287.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,2NC43@225057|Acidithiobacillales	225057|Acidithiobacillales	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
GNS2_k127_1707647_8	1184267.A11Q_2613	2.73e-67	238.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2MSXG@213481|Bdellovibrionales,2WNG8@28221|Deltaproteobacteria	213481|Bdellovibrionales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
GNS2_k127_1707647_2	643648.Slip_0768	2.516e-140	461.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42JR8@68298|Syntrophomonadaceae	186801|Clostridia	H	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
GNS2_k127_1707647_4	981383.AEWH01000018_gene3209	1.888e-118	394.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
GNS2_k127_1806844_1	700598.Niako_5047	5.835e-108	351.0	COG0482@1|root,COG0482@2|Bacteria,4NFXZ@976|Bacteroidetes,1IR3X@117747|Sphingobacteriia	976|Bacteroidetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
GNS2_k127_1806844_0	866536.Belba_1971	6.123e-177	568.0	COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,47NCX@768503|Cytophagia	976|Bacteroidetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
GNS2_k127_1819284_9	1123511.KB905864_gene2557	4.44e-11	73.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,4H2C0@909932|Negativicutes	909932|Negativicutes	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
GNS2_k127_1819284_0	497964.CfE428DRAFT_4279	6.276e-73	263.0	COG0773@1|root,COG0773@2|Bacteria,46THM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mur ligase middle domain protein	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
GNS2_k127_1819284_6	929562.Emtol_1837	5.181e-19	95.0	COG2935@1|root,COG2935@2|Bacteria,4P1RD@976|Bacteroidetes,47U44@768503|Cytophagia	976|Bacteroidetes	O	PFAM Arginine-tRNA-protein transferase, C terminus	-	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	Acetyltransf_6
GNS2_k127_1819284_4	1423816.BACQ01000014_gene519	4.198e-45	177.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,4H9TP@91061|Bacilli,3F3YP@33958|Lactobacillaceae	91061|Bacilli	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
GNS2_k127_1819284_10	1123258.AQXZ01000018_gene363	1.396e-08	67.0	COG0439@1|root,COG0439@2|Bacteria,2HTQR@201174|Actinobacteria,4G5VI@85025|Nocardiaceae	201174|Actinobacteria	I	Biotin carboxylase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
GNS2_k127_1819284_2	273068.TTE1836	3.309e-54	202.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,42ETQ@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
GNS2_k127_1819284_11	926556.Echvi_0828	1.923e-06	54.0	COG1544@1|root,COG1544@2|Bacteria,4NUME@976|Bacteroidetes,47QMB@768503|Cytophagia	976|Bacteroidetes	J	PFAM Sigma 54 modulation protein S30EA ribosomal protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
GNS2_k127_1819284_7	864051.BurJ1DRAFT_2911	8.737e-18	98.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
GNS2_k127_1819284_5	1121324.CLIT_11c02670	6.222e-29	121.0	2E74N@1|root,331P2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1819284_8	1449338.JQLU01000005_gene3073	5.399e-16	82.0	COG4818@1|root,COG4818@2|Bacteria,1VG59@1239|Firmicutes,4HP4V@91061|Bacilli	91061|Bacilli	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1819284_3	243161.TC_0131	3.945e-50	202.0	COG0021@1|root,COG0021@2|Bacteria,2JFFT@204428|Chlamydiae	204428|Chlamydiae	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
GNS2_k127_1819284_1	1158345.JNLL01000001_gene79	4.803e-57	213.0	COG0820@1|root,COG0820@2|Bacteria,2G3QF@200783|Aquificae	200783|Aquificae	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
GNS2_k127_1819284_12	546269.HMPREF0389_00287	4.851e-05	50.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,25QNU@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
GNS2_k127_1874896_6	760142.Hipma_0827	1.675e-130	436.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
GNS2_k127_1874896_19	575588.ACPN01000134_gene1945	0.0001018	47.0	2A2R8@1|root,30R45@2|Bacteria,1QBY9@1224|Proteobacteria,1T7JH@1236|Gammaproteobacteria,3NSE4@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1874896_14	871968.DESME_13100	4.501e-28	117.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,2627X@186807|Peptococcaceae	186801|Clostridia	S	PFAM MgtC	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	ACT,ACT_4,MgtC
GNS2_k127_1874896_4	204536.SULAZ_1268	1.995e-139	473.0	COG0474@1|root,COG0474@2|Bacteria	2|Bacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,LPG_synthase_TM
GNS2_k127_1874896_11	682795.AciX8_1628	8.725e-30	121.0	2CC1B@1|root,32RUI@2|Bacteria,3Y56C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1874896_5	1487921.DP68_06585	3.716e-139	451.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
GNS2_k127_1874896_15	558169.AGAV01000012_gene1845	3.296e-11	72.0	COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4HKW3@91061|Bacilli	91061|Bacilli	S	Protein conserved in bacteria	ymfM	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
GNS2_k127_1874896_3	484770.UFO1_4469	2.509e-149	500.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4H1X4@909932|Negativicutes	909932|Negativicutes	D	FtsK SpoIIIE family protein	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
GNS2_k127_1874896_0	760568.Desku_3065	0.0	1289.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,25ZXZ@186807|Peptococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
GNS2_k127_1874896_1	351627.Csac_0952	0.0	1200.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,42FED@68295|Thermoanaerobacterales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
GNS2_k127_1874896_8	1191523.MROS_0745	1.336e-63	226.0	COG0217@1|root,COG0217@2|Bacteria	2|Bacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
GNS2_k127_1874896_9	373903.Hore_12330	6.401e-45	169.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,3WBQ3@53433|Halanaerobiales	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
GNS2_k127_1874896_17	1278073.MYSTI_06571	1.966e-05	52.0	COG0454@1|root,COG0456@2|Bacteria,1NEWG@1224|Proteobacteria,42VG1@68525|delta/epsilon subdivisions,2WRCC@28221|Deltaproteobacteria,2Z1UQ@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
GNS2_k127_1874896_10	880073.Calab_0477	6.062e-40	153.0	COG0566@1|root,COG0566@2|Bacteria,2NQ0F@2323|unclassified Bacteria	2|Bacteria	J	tRNA rRNA methyltransferase	spoU	-	2.1.1.185	ko:K03218,ko:K03437	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase
GNS2_k127_1874896_16	1504319.GM45_3410	1.562e-07	63.0	COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria,3UX07@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
GNS2_k127_1874896_7	986075.CathTA2_0145	4.547e-64	232.0	COG3634@1|root,COG3634@2|Bacteria,1TPYN@1239|Firmicutes,4H9W1@91061|Bacilli	91061|Bacilli	O	alkyl hydroperoxide reductase	ahpF	-	-	ko:K03387	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
GNS2_k127_1874896_12	243164.DET0642	5.717e-29	124.0	COG0036@1|root,COG0036@2|Bacteria,2G6EU@200795|Chloroflexi,34D4E@301297|Dehalococcoidia	301297|Dehalococcoidia	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
GNS2_k127_1874896_13	648996.Theam_1218	7.636e-29	121.0	COG0698@1|root,COG0698@2|Bacteria,2G43P@200783|Aquificae	200783|Aquificae	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
GNS2_k127_1874896_2	665571.STHERM_c15920	1.641e-284	904.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
GNS2_k127_1874896_18	1163407.UU7_09957	3.934e-05	46.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1X4G1@135614|Xanthomonadales	135614|Xanthomonadales	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
GNS2_k127_1991116_30	313612.L8106_14590	8.318e-20	106.0	COG2730@1|root,COG2931@1|root,COG3386@1|root,COG2730@2|Bacteria,COG2931@2|Bacteria,COG3386@2|Bacteria,1G3DW@1117|Cyanobacteria,1HAZM@1150|Oscillatoriales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,DUF4347,HemolysinCabind
GNS2_k127_1991116_15	648996.Theam_0215	4.058e-66	236.0	COG0223@1|root,COG0223@2|Bacteria,2G3PD@200783|Aquificae	200783|Aquificae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
GNS2_k127_1991116_24	699218.HMPREF0889_1627	1.661e-29	123.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,4H4D6@909932|Negativicutes	909932|Negativicutes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
GNS2_k127_1991116_17	1122143.AUEG01000001_gene180	9.018e-66	248.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,27FEP@186828|Carnobacteriaceae	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
GNS2_k127_1991116_20	608506.COB47_0323	2.579e-51	191.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,42EU7@68295|Thermoanaerobacterales	186801|Clostridia	S	Extradiol ring-cleavage dioxygenase, class III	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
GNS2_k127_1991116_29	31964.CMS0641	4.481e-21	109.0	COG3757@1|root,COG5479@1|root,COG3757@2|Bacteria,COG5479@2|Bacteria,2HYIN@201174|Actinobacteria,4FMC4@85023|Microbacteriaceae	201174|Actinobacteria	M	hydrolase, family 25	-	-	-	-	-	-	-	-	-	-	-	-	LGFP,LysM,VCBS
GNS2_k127_1991116_0	589865.DaAHT2_0063	2.761e-310	973.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
GNS2_k127_1991116_14	926569.ANT_03500	1.256e-69	243.0	COG0020@1|root,COG0020@2|Bacteria,2G65C@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
GNS2_k127_1991116_19	580331.Thit_1850	2.324e-52	195.0	COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,42FEU@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid	tarA	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,PS_pyruv_trans
GNS2_k127_1991116_6	862517.HMPREF9225_0123	1.65e-143	470.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,22FXI@1570339|Peptoniphilaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
GNS2_k127_1991116_26	429009.Adeg_0473	3.198e-27	125.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,42FSF@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Peptidase M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
GNS2_k127_1991116_23	1250005.PHEL85_1275	7.752e-30	120.0	2E32V@1|root,32Y33@2|Bacteria,4NWGB@976|Bacteroidetes,1I5F2@117743|Flavobacteriia,3VXDK@52959|Polaribacter	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_1991116_16	879212.DespoDRAFT_02053	8.046e-66	237.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2WJ7Q@28221|Deltaproteobacteria,2MI9U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
GNS2_k127_1991116_4	161156.JQKW01000001_gene1433	1.488e-148	495.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GH97@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Succinyl-CoA ligase like flavodoxin domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
GNS2_k127_1991116_7	768670.Calni_1986	1.485e-131	439.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GENW@200930|Deferribacteres	200930|Deferribacteres	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
GNS2_k127_1991116_12	768670.Calni_1987	1.997e-80	276.0	COG1013@1|root,COG1013@2|Bacteria,2GF37@200930|Deferribacteres	200930|Deferribacteres	C	oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
GNS2_k127_1991116_32	526222.Desal_0805	1.765e-11	70.0	COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,42Q5G@68525|delta/epsilon subdivisions,2WPZ8@28221|Deltaproteobacteria,2MBXP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM flavodoxin nitric oxide synthase	-	-	-	ko:K03839	-	-	-	-	ko00000	-	-	-	Flavodoxin_1
GNS2_k127_1991116_21	457570.Nther_1668	2.541e-45	177.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia	186801|Clostridia	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
GNS2_k127_1991116_13	398512.JQKC01000019_gene3508	2.687e-80	282.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WGQU@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
GNS2_k127_1991116_8	221027.JO40_01735	2.207e-128	422.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
GNS2_k127_1991116_33	411470.RUMGNA_00306	1.374e-08	66.0	COG1051@1|root,COG1051@2|Bacteria,1UIGB@1239|Firmicutes,24NCA@186801|Clostridia,3Y0DG@572511|Blautia	186801|Clostridia	F	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
GNS2_k127_1991116_25	580331.Thit_0597	2.992e-28	126.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,42G2V@68295|Thermoanaerobacterales	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
GNS2_k127_1991116_27	273116.14325477	1.224e-26	114.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,241VG@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
GNS2_k127_1991116_5	309801.trd_0874	1.206e-143	470.0	COG1190@1|root,COG1190@2|Bacteria,2G65Z@200795|Chloroflexi,27XMG@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
GNS2_k127_1991116_22	1121085.AUCI01000003_gene3301	4.971e-33	133.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,4HGZU@91061|Bacilli,1ZFQI@1386|Bacillus	91061|Bacilli	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
GNS2_k127_1991116_11	373903.Hore_14210	7.722e-104	361.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,3WA9D@53433|Halanaerobiales	186801|Clostridia	M	Penicillin-binding protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
GNS2_k127_1991116_31	404380.Gbem_2462	2.049e-14	83.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,43TCT@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
GNS2_k127_1991116_9	1121430.JMLG01000002_gene999	5.802e-112	372.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,260KS@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
GNS2_k127_1991116_3	671143.DAMO_2896	1.243e-181	603.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria	2|Bacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
GNS2_k127_1991116_10	1122169.AREN01000005_gene1825	9.803e-112	382.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1JCHU@118969|Legionellales	118969|Legionellales	V	to multidrug resistance ABC transporter ATP-binding protein	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
GNS2_k127_1991116_28	255470.cbdbA539	4.163e-23	103.0	COG0355@1|root,COG0355@2|Bacteria,2G70H@200795|Chloroflexi,34DAK@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
GNS2_k127_1991116_1	526218.Sterm_0203	4.526e-217	681.0	COG0055@1|root,COG0055@2|Bacteria,3794W@32066|Fusobacteria	32066|Fusobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
GNS2_k127_1991116_18	479434.Sthe_1422	2.023e-60	219.0	COG0224@1|root,COG0224@2|Bacteria,2G69I@200795|Chloroflexi,27XXK@189775|Thermomicrobia	189775|Thermomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
GNS2_k127_1991116_2	1121430.JMLG01000002_gene1219	1.793e-198	629.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,260JV@186807|Peptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
GNS2_k127_1991116_35	398511.BpOF4_06865	1.825e-07	58.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,4HKFW@91061|Bacilli,1ZG65@1386|Bacillus	91061|Bacilli	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
GNS2_k127_1991116_34	742741.HMPREF9475_00612	1.476e-07	60.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,220SD@1506553|Lachnoclostridium	186801|Clostridia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
GNS2_k127_2107482_0	883114.HMPREF9709_01616	0.0004003	48.0	COG3204@1|root,COG3204@2|Bacteria	2|Bacteria	L	pilus organization	-	-	-	-	-	-	-	-	-	-	-	-	LTD,Phytase-like
GNS2_k127_219612_0	484018.BACPLE_01381	3.358e-145	472.0	COG3039@1|root,COG3039@2|Bacteria,4NHF4@976|Bacteroidetes,2FN6F@200643|Bacteroidia	976|Bacteroidetes	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
GNS2_k127_219612_1	760192.Halhy_0656	7.157e-78	264.0	COG1297@1|root,COG1297@2|Bacteria,4NEIY@976|Bacteroidetes,1IP8J@117747|Sphingobacteriia	976|Bacteroidetes	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
GNS2_k127_2292352_13	1210908.HSB1_09120	1.7e-20	100.0	COG0500@1|root,arCOG04583@2157|Archaea,2XTVC@28890|Euryarchaeota,23ST5@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
GNS2_k127_2292352_3	1237149.C900_04621	2.907e-90	306.0	COG0861@1|root,COG0861@2|Bacteria,4NH7P@976|Bacteroidetes,47N45@768503|Cytophagia	976|Bacteroidetes	P	PFAM Integral membrane protein TerC	ygjT	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
GNS2_k127_2292352_14	1229909.NSED_03715	4.397e-20	99.0	arCOG03272@1|root,arCOG03272@2157|Archaea,41T3V@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2292352_12	1232447.BAHW02000055_gene3240	4.061e-22	97.0	COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,24QYU@186801|Clostridia,269QG@186813|unclassified Clostridiales	186801|Clostridia	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
GNS2_k127_2292352_17	47839.CCAU010000004_gene1043	5.993e-15	87.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
GNS2_k127_2292352_7	1121090.KB894685_gene3461	2.439e-53	213.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1TR1R@1239|Firmicutes,4H9V8@91061|Bacilli,1ZC19@1386|Bacillus	91061|Bacilli	CE	COG0665 Glycine D-amino acid oxidases (deaminating)	yhfW	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
GNS2_k127_2292352_15	396588.Tgr7_0172	5.615e-16	80.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1WZ2Z@135613|Chromatiales	135613|Chromatiales	K	PFAM Cold-shock protein, DNA-binding	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
GNS2_k127_2292352_10	479434.Sthe_3291	4.368e-24	110.0	COG4549@1|root,COG4549@2|Bacteria	2|Bacteria	S	Domain of unkown function (DUF1775)	ycnI	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF1775
GNS2_k127_2292352_18	937777.Deipe_2532	8.601e-11	69.0	2ADER@1|root,3134N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2292352_6	858215.Thexy_0601	2.268e-72	258.0	COG0477@1|root,COG2814@2|Bacteria,1UY55@1239|Firmicutes,24DWA@186801|Clostridia,42FY3@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
GNS2_k127_2292352_11	485913.Krac_3441	8.855e-23	103.0	COG3976@1|root,COG3976@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
GNS2_k127_2292352_4	485913.Krac_3440	5.086e-89	300.0	COG1477@1|root,COG1477@2|Bacteria	2|Bacteria	H	protein flavinylation	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE,DUF2271
GNS2_k127_2292352_0	485913.Krac_3439	5.088e-162	524.0	COG1018@1|root,COG1018@2|Bacteria,2G9BE@200795|Chloroflexi	2|Bacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1,NQR2_RnfD_RnfE
GNS2_k127_2292352_9	1460640.JCM19046_2	2.739e-32	132.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,1ZCZ4@1386|Bacillus	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GNS2_k127_2292352_16	935948.KE386494_gene659	7.748e-16	91.0	COG0845@1|root,COG0845@2|Bacteria,1TT2M@1239|Firmicutes,24BJV@186801|Clostridia,42GDS@68295|Thermoanaerobacterales	186801|Clostridia	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
GNS2_k127_2292352_5	502558.EGYY_21940	1.79e-80	274.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4CV1R@84998|Coriobacteriia	84998|Coriobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GNS2_k127_2292352_2	871968.DESME_13845	1.416e-104	353.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,260DV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GNS2_k127_2292352_19	1449976.KALB_8333	2.967e-05	53.0	2DR37@1|root,339ZB@2|Bacteria,2ISNH@201174|Actinobacteria,4E5TP@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2292352_20	1045854.WKK_05515	0.0002743	47.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
GNS2_k127_2292352_1	1121403.AUCV01000017_gene4453	4.935e-152	494.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2MI5B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
GNS2_k127_2292352_8	237368.SCABRO_03309	3.719e-53	204.0	COG1611@1|root,COG1611@2|Bacteria,2IZCH@203682|Planctomycetes	203682|Planctomycetes	NOU	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
GNS2_k127_237172_2	1237149.C900_04436	1.167e-07	63.0	COG4733@1|root,COG4886@1|root,COG5306@1|root,COG4733@2|Bacteria,COG4886@2|Bacteria,COG5306@2|Bacteria,4NI2K@976|Bacteroidetes,47TBD@768503|Cytophagia	976|Bacteroidetes	S	Leucine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,He_PIG,Ig_3,LRRNT_2,LRR_1,LRR_8,Peptidase_M64,VCBS
GNS2_k127_237172_0	1121896.JMLU01000052_gene1260	1.159e-23	112.0	2BFD6@1|root,3296M@2|Bacteria,4NQWY@976|Bacteroidetes,1I31C@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_237172_1	883080.HMPREF9697_04035	9.556e-08	58.0	COG1403@1|root,COG1403@2|Bacteria,1N6FJ@1224|Proteobacteria,2UEHE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2391580_2	717605.Theco_0206	4.169e-08	56.0	COG0457@1|root,COG3012@1|root,COG0457@2|Bacteria,COG3012@2|Bacteria,1V51C@1239|Firmicutes,4HMAA@91061|Bacilli,26USV@186822|Paenibacillaceae	91061|Bacilli	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C,ST7,TPR_19
GNS2_k127_2391580_0	269797.Mbar_A2208	1.414e-154	501.0	COG3385@1|root,arCOG04496@2157|Archaea,2Y7GJ@28890|Euryarchaeota,2N9SD@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1
GNS2_k127_2391580_1	1403313.AXBR01000012_gene1241	5.08e-39	152.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,1ZPZP@1386|Bacillus	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
GNS2_k127_2479909_60	1163407.UU7_09957	3.934e-05	46.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1X4G1@135614|Xanthomonadales	135614|Xanthomonadales	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
GNS2_k127_2479909_53	485914.Hmuk_1990	9.718e-14	77.0	COG0494@1|root,arCOG01080@2157|Archaea,2XX75@28890|Euryarchaeota,23VM7@183963|Halobacteria	183963|Halobacteria	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
GNS2_k127_2479909_46	1107311.Q767_10090	3.85e-23	102.0	2E3QV@1|root,32YNP@2|Bacteria,4NX04@976|Bacteroidetes,1I5VK@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
GNS2_k127_2479909_51	1460635.JCM19038_1061	9.479e-17	83.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,4HKJV@91061|Bacilli	91061|Bacilli	S	Transcriptional regulator	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
GNS2_k127_2479909_15	1304865.JAGF01000001_gene2536	3.341e-93	321.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,2IETB@201174|Actinobacteria	201174|Actinobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
GNS2_k127_2479909_41	118161.KB235922_gene676	1.187e-28	119.0	COG4633@1|root,COG4633@2|Bacteria,1G713@1117|Cyanobacteria,3VM9G@52604|Pleurocapsales	1117|Cyanobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
GNS2_k127_2479909_37	296591.Bpro_1179	1.091e-39	153.0	2BQZQ@1|root,32JX2@2|Bacteria,1RJP3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
GNS2_k127_2479909_0	1047013.AQSP01000120_gene942	1.292e-246	782.0	COG2217@1|root,COG2217@2|Bacteria,2NNPJ@2323|unclassified Bacteria	2|Bacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
GNS2_k127_2479909_52	867845.KI911784_gene1605	3.599e-15	91.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	CARDB,DUF4091,FlgD_ig,Laminin_G_3,PKD,Peptidase_M43
GNS2_k127_2479909_25	933262.AXAM01000021_gene479	2.55e-60	238.0	COG1075@1|root,COG1404@1|root,COG2304@1|root,COG3507@1|root,COG1075@2|Bacteria,COG1404@2|Bacteria,COG2304@2|Bacteria,COG3507@2|Bacteria,1NDGA@1224|Proteobacteria,43DCN@68525|delta/epsilon subdivisions,2WRRD@28221|Deltaproteobacteria,2MME4@213118|Desulfobacterales	28221|Deltaproteobacteria	G	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
GNS2_k127_2479909_59	886377.Murru_2212	2.766e-05	52.0	295NE@1|root,2ZSZT@2|Bacteria,4NPQK@976|Bacteroidetes,1I3MJ@117743|Flavobacteriia	976|Bacteroidetes	S	DoxX	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
GNS2_k127_2479909_44	457570.Nther_0399	1.632e-23	105.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia	186801|Clostridia	K	Hydrolase, P-loop family	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
GNS2_k127_2479909_14	1410653.JHVC01000001_gene1839	2.577e-95	323.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,36E42@31979|Clostridiaceae	186801|Clostridia	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
GNS2_k127_2479909_4	945713.IALB_1702	1.536e-131	436.0	COG0617@1|root,COG0617@2|Bacteria	2|Bacteria	J	CTP:tRNA cytidylyltransferase activity	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
GNS2_k127_2479909_13	635013.TherJR_2303	5.127e-99	345.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,2600X@186807|Peptococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
GNS2_k127_2479909_11	1449126.JQKL01000017_gene2766	1.187e-106	360.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,267PJ@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
GNS2_k127_2479909_61	1121382.JQKG01000023_gene1491	0.000842	51.0	COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,1WIDK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NHL,Pkinase
GNS2_k127_2479909_27	861454.HMPREF9099_02332	1.794e-56	211.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,27INU@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
GNS2_k127_2479909_50	1064535.MELS_1810	1.644e-17	95.0	COG0814@1|root,COG0814@2|Bacteria,1UTY5@1239|Firmicutes,4H6YP@909932|Negativicutes	909932|Negativicutes	E	Tryptophan/tyrosine permease family	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
GNS2_k127_2479909_48	929703.KE386491_gene1828	8.477e-21	108.0	COG3307@1|root,COG3307@2|Bacteria	2|Bacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
GNS2_k127_2479909_22	123214.PERMA_1993	2.55e-75	261.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
GNS2_k127_2479909_18	457396.CSBG_00718	2.176e-83	287.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,36K44@31979|Clostridiaceae	186801|Clostridia	M	NAD(P)H-binding	-	-	4.2.1.45,4.2.1.46,5.1.3.2	ko:K01709,ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02426,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
GNS2_k127_2479909_8	1280676.AUJO01000027_gene3069	9.193e-112	367.0	COG4569@1|root,COG4569@2|Bacteria,1TQJS@1239|Firmicutes,248JS@186801|Clostridia	186801|Clostridia	Q	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	mhpF	-	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AcetDehyd-dimer,Semialdhyde_dh
GNS2_k127_2479909_7	1270193.JARP01000003_gene1925	1.068e-113	376.0	COG0119@1|root,COG0119@2|Bacteria,4NHR2@976|Bacteroidetes,1HZQE@117743|Flavobacteriia	976|Bacteroidetes	E	HMGL-like	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
GNS2_k127_2479909_1	1280676.AUJO01000027_gene3067	2.75e-226	716.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,248Z9@186801|Clostridia,4BW52@830|Butyrivibrio	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
GNS2_k127_2479909_21	679926.Mpet_1373	2.224e-76	265.0	COG0451@1|root,arCOG01369@2157|Archaea	2157|Archaea	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.271,1.1.1.339,4.2.1.46,5.1.3.2	ko:K01710,ko:K01784,ko:K02377,ko:K19180	ko00051,ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00051,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R05692,R06513,R10190	RC00182,RC00289,RC00402,RC01014	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
GNS2_k127_2479909_3	1501230.ET33_00575	5.49e-136	438.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,4HC2Z@91061|Bacilli,271Y5@186822|Paenibacillaceae	91061|Bacilli	M	Dolichol monophosphate mannose synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GNS2_k127_2479909_55	1254432.SCE1572_17615	1.045e-11	73.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574,ko:K06889	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4743,NUDIX,Nudix_N
GNS2_k127_2479909_2	419665.Maeo_0388	2.631e-183	583.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23QJ1@183939|Methanococci	28890|Euryarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	1.17.1.1,2.6.1.102	ko:K12452,ko:K13010	ko00520,map00520	-	R03391,R03392,R10460	RC00006,RC00230,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
GNS2_k127_2479909_57	1121428.DESHY_80028___1	4.729e-10	72.0	2DQ2F@1|root,334G7@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K14337	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	-
GNS2_k127_2479909_56	391623.TERMP_02119	1.662e-11	76.0	COG2244@1|root,arCOG02209@2157|Archaea,2XUGQ@28890|Euryarchaeota,245B5@183968|Thermococci	183968|Thermococci	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_C
GNS2_k127_2479909_42	1121451.DESAM_22927	1.851e-26	124.0	COG0438@1|root,COG0438@2|Bacteria,1R9QG@1224|Proteobacteria,42PQQ@68525|delta/epsilon subdivisions,2WTQJ@28221|Deltaproteobacteria,2M9KJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
GNS2_k127_2479909_5	1047013.AQSP01000116_gene1117	1.213e-118	389.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
GNS2_k127_2479909_10	1047013.AQSP01000116_gene1112	3.453e-111	368.0	COG2605@1|root,COG2605@2|Bacteria,2NP6Q@2323|unclassified Bacteria	2|Bacteria	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
GNS2_k127_2479909_16	1047013.AQSP01000116_gene1110	3.474e-91	315.0	COG1004@1|root,COG1004@2|Bacteria,2NNYN@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
GNS2_k127_2479909_24	1116472.MGMO_94c00210	9.252e-62	222.0	COG1028@1|root,COG1028@2|Bacteria,1QWF5@1224|Proteobacteria,1T5MF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
GNS2_k127_2479909_19	1047013.AQSP01000116_gene1113	2.366e-83	288.0	COG0673@1|root,COG0673@2|Bacteria,2NQ2X@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
GNS2_k127_2479909_49	1408322.JHYK01000014_gene1823	5.493e-20	93.0	COG0279@1|root,COG0279@2|Bacteria,1V610@1239|Firmicutes,24HXA@186801|Clostridia,27MVU@186928|unclassified Lachnospiraceae	186801|Clostridia	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
GNS2_k127_2479909_31	1410633.JHWR01000001_gene1417	1.13e-46	175.0	COG0241@1|root,COG1208@1|root,COG0241@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,27J50@186928|unclassified Lachnospiraceae	186801|Clostridia	EJM	Nucleotidyl transferase	gmhB	-	2.7.7.71,3.1.3.82,3.1.3.83	ko:K03273,ko:K15669	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771,R09772	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like,NTP_transferase,PNK3P
GNS2_k127_2479909_34	1047013.AQSP01000116_gene1116	1.594e-44	171.0	COG1208@1|root,COG1208@2|Bacteria,2NR0X@2323|unclassified Bacteria	2|Bacteria	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
GNS2_k127_2479909_32	1047013.AQSP01000144_gene845	1.654e-46	176.0	COG0176@1|root,COG0176@2|Bacteria,2NP61@2323|unclassified Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
GNS2_k127_2479909_43	858215.Thexy_2159	9.14e-25	114.0	COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,1TQEM@1239|Firmicutes,249HH@186801|Clostridia,42JEF@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 2	sunS	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,TPR_2,TPR_8
GNS2_k127_2479909_47	1430440.MGMSRv2_3374	2.058e-21	98.0	COG1917@1|root,COG1917@2|Bacteria,1NMKX@1224|Proteobacteria,2UY6M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2479909_6	1430440.MGMSRv2_3375	1.533e-117	406.0	COG4976@1|root,COG4976@2|Bacteria,1QW8Z@1224|Proteobacteria,2TWTG@28211|Alphaproteobacteria,2JZ6K@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
GNS2_k127_2479909_12	1430440.MGMSRv2_3376	1.82e-104	367.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,2JVSV@204441|Rhodospirillales	204441|Rhodospirillales	GM	Male sterility protein	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
GNS2_k127_2479909_36	65393.PCC7424_5773	1.956e-40	162.0	COG0673@1|root,COG0673@2|Bacteria,1G1CZ@1117|Cyanobacteria,3KG15@43988|Cyanothece	1117|Cyanobacteria	S	oxidoreductase domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GNS2_k127_2479909_33	351160.LRC551	1.225e-44	177.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUKT@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
GNS2_k127_2479909_28	1303518.CCALI_00571	1.635e-55	202.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GNS2_k127_2479909_35	391623.TERMP_01739	1.799e-43	181.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
GNS2_k127_2479909_38	634956.Geoth_0305	3.966e-39	157.0	COG1216@1|root,COG1216@2|Bacteria,1UVKN@1239|Firmicutes,4I2BN@91061|Bacilli,1WHQ2@129337|Geobacillus	91061|Bacilli	M	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
GNS2_k127_2479909_39	1122927.KB895421_gene3948	2.036e-37	152.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,4HEJ1@91061|Bacilli,26TD7@186822|Paenibacillaceae	91061|Bacilli	S	glycosyl transferase family 2	galnac-T15	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glyco_transf_7C,Glycos_transf_2
GNS2_k127_2479909_30	1123518.ARWI01000001_gene869	1.056e-52	198.0	COG0451@1|root,COG0451@2|Bacteria,1RBIE@1224|Proteobacteria,1SZHR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
GNS2_k127_2479909_26	1220534.B655_0998	4.293e-57	202.0	COG1898@1|root,arCOG04188@2157|Archaea,2XWJQ@28890|Euryarchaeota	28890|Euryarchaeota	M	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
GNS2_k127_2479909_29	926550.CLDAP_16140	4.26e-53	199.0	COG1215@1|root,COG1215@2|Bacteria,2G6E4@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3,Glycos_transf_2
GNS2_k127_2479909_23	1216932.CM240_2392	6.159e-68	240.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,249T1@186801|Clostridia,36HGQ@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Methyltransf_23
GNS2_k127_2479909_9	357808.RoseRS_1617	1.118e-111	376.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi,375IW@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
GNS2_k127_2479909_20	246194.CHY_1057	2.298e-77	269.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,42JFW@68295|Thermoanaerobacterales	186801|Clostridia	M	RmlD substrate binding domain	-	-	4.1.1.35,5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274,ko:K08678	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R01384,R02984,R05176	RC00289,RC00508,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
GNS2_k127_2479909_45	377629.TERTU_0961	2.607e-23	101.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,2PNTF@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Ribosomal L27 protein	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
GNS2_k127_2479909_17	941639.BCO26_1019	3.3e-85	294.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4HAEV@91061|Bacilli,1ZBY5@1386|Bacillus	91061|Bacilli	D	Belongs to the SEDS family	spoVE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
GNS2_k127_263037_1	484770.UFO1_0665	1.327e-11	76.0	COG2865@1|root,COG2865@2|Bacteria,1VS91@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_263037_0	1444711.CCJF01000005_gene497	9.426e-127	426.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2JGVC@204428|Chlamydiae	204428|Chlamydiae	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
GNS2_k127_2715772_0	1405.DJ92_4522	6.748e-19	93.0	COG3682@1|root,COG3682@2|Bacteria,1VGZ0@1239|Firmicutes	1239|Firmicutes	K	PFAM Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
GNS2_k127_2715772_1	1122917.KB899662_gene2251	5.278e-11	72.0	COG0501@1|root,COG0501@2|Bacteria,1V4KK@1239|Firmicutes,4HH1T@91061|Bacilli,26UDD@186822|Paenibacillaceae	91061|Bacilli	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,Peptidase_M56
GNS2_k127_2785313_1	234267.Acid_2341	1.336e-38	169.0	COG3055@1|root,COG5306@1|root,COG3055@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,Malectin,MotA_ExbB
GNS2_k127_2785313_2	377629.TERTU_3505	1.552e-34	155.0	COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,1T32K@1236|Gammaproteobacteria,2PQ9Q@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	U	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin_3,Calx-beta,DUF4347,He_PIG,OmpA_membrane
GNS2_k127_2785313_3	694427.Palpr_2226	4.22e-33	151.0	COG3656@1|root,COG3656@2|Bacteria,4NHDQ@976|Bacteroidetes,2FTSH@200643|Bacteroidia,22Y91@171551|Porphyromonadaceae	976|Bacteroidetes	S	Fibronectin type 3 domain	-	-	-	ko:K21571	-	-	-	-	ko00000	-	-	-	-
GNS2_k127_2785313_6	398511.BpOF4_06055	1.158e-07	66.0	COG0366@1|root,COG0823@1|root,COG0366@2|Bacteria,COG0823@2|Bacteria,1UJZV@1239|Firmicutes,4ITG4@91061|Bacilli,1ZG7U@1386|Bacillus	91061|Bacilli	G	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
GNS2_k127_2785313_7	1122239.AULS01000003_gene2668	5.192e-07	63.0	COG4967@1|root,COG4967@2|Bacteria,2I5QI@201174|Actinobacteria,4FRV8@85023|Microbacteriaceae	201174|Actinobacteria	NU	type IV pilus modification protein PilV	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
GNS2_k127_2785313_5	1048339.KB913029_gene1852	1.775e-09	70.0	COG4726@1|root,COG4726@2|Bacteria,2ID24@201174|Actinobacteria	201174|Actinobacteria	NU	pilus assembly protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2785313_0	37659.JNLN01000001_gene1367	8.25e-93	312.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
GNS2_k127_2785313_4	1476583.DEIPH_ctg011orf0221	5.059e-19	100.0	COG2182@1|root,COG2182@2|Bacteria,1WJNV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
GNS2_k127_2785313_8	263358.VAB18032_15915	0.0001671	49.0	2EEUC@1|root,338MW@2|Bacteria,2IQC9@201174|Actinobacteria,4DFBJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TrbC
GNS2_k127_2981726_6	304371.MCP_0795	3.207e-43	164.0	COG4430@1|root,arCOG10241@2157|Archaea,2XUJA@28890|Euryarchaeota	28890|Euryarchaeota	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
GNS2_k127_2981726_15	935836.JAEL01000123_gene2183	0.000408	52.0	COG5513@1|root,COG5513@2|Bacteria,1V4PH@1239|Firmicutes,4HG7Y@91061|Bacilli,1ZG3W@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF3298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
GNS2_k127_2981726_2	926561.KB900618_gene441	1.571e-138	458.0	COG0827@1|root,COG0827@2|Bacteria,1U6WB@1239|Firmicutes,24CQS@186801|Clostridia	186801|Clostridia	L	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_Mtase
GNS2_k127_2981726_9	1500281.JQKZ01000035_gene88	1.276e-34	140.0	COG1403@1|root,COG1403@2|Bacteria,4NTPV@976|Bacteroidetes,1I6E9@117743|Flavobacteriia	976|Bacteroidetes	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
GNS2_k127_2981726_1	1500281.JQKZ01000035_gene90	3.517e-188	612.0	COG4191@1|root,COG4191@2|Bacteria,4P85X@976|Bacteroidetes,1IJVC@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_3
GNS2_k127_2981726_11	68260.JOAY01000058_gene5374	3.464e-20	106.0	2DZA9@1|root,32V71@2|Bacteria,2IF7X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2981726_14	935836.JAEL01000083_gene1136	8.824e-09	66.0	28KEB@1|root,2ZA0K@2|Bacteria,1V14E@1239|Firmicutes,4HNU7@91061|Bacilli	91061|Bacilli	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_2981726_3	760142.Hipma_0827	2.643e-74	271.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
GNS2_k127_2981726_10	1217715.F994_00629	3.953e-27	122.0	2E6I3@1|root,33159@2|Bacteria,1NABC@1224|Proteobacteria,1S4VK@1236|Gammaproteobacteria,3NK71@468|Moraxellaceae	1236|Gammaproteobacteria	S	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
GNS2_k127_2981726_4	856793.MICA_2022	5.57e-55	211.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria,4BPTW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
GNS2_k127_2981726_5	1197906.CAJQ02000041_gene4883	4.015e-52	195.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,3K4FA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
GNS2_k127_2981726_12	926550.CLDAP_39000	1.466e-19	96.0	COG1595@1|root,COG1595@2|Bacteria,2G6X7@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
GNS2_k127_2981726_0	1121918.ARWE01000001_gene1260	5.101e-209	665.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,43RZZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
GNS2_k127_2981726_8	562970.Btus_1426	5.006e-38	153.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,277VY@186823|Alicyclobacillaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
GNS2_k127_2981726_13	28042.GU90_17610	1.201e-11	69.0	COG1321@1|root,COG1321@2|Bacteria,2GK7P@201174|Actinobacteria,4DYN2@85010|Pseudonocardiales	201174|Actinobacteria	K	Transcriptional regulator	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
GNS2_k127_3073773_26	443143.GM18_4076	2.743e-09	67.0	COG4269@1|root,COG4269@2|Bacteria	2|Bacteria	T	membrane	yjgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF898
GNS2_k127_3073773_23	523850.TON_0196	1.515e-12	76.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,242TV@183968|Thermococci	183968|Thermococci	F	thymidylate kinase	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
GNS2_k127_3073773_17	479435.Kfla_5968	2.771e-40	154.0	COG0262@1|root,COG0262@2|Bacteria,2IM1S@201174|Actinobacteria,4DRHC@85009|Propionibacteriales	201174|Actinobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1,NUDIX
GNS2_k127_3073773_2	1121396.KB893101_gene475	2.564e-125	406.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,42PY3@68525|delta/epsilon subdivisions,2WV23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	-	-	-	-	-	-	-	-	-	-	Thymidylat_synt
GNS2_k127_3073773_15	485913.Krac_8660	3.778e-46	170.0	COG0756@1|root,COG0756@2|Bacteria	2|Bacteria	F	dUTP diphosphatase activity	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	iYO844.BSU17660	dUTPase
GNS2_k127_3073773_27	415426.Hbut_0338	4.069e-09	65.0	COG0237@1|root,arCOG01045@2157|Archaea,2XQTJ@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,AAA_18
GNS2_k127_3073773_13	1392491.JIAE01000001_gene387	7.915e-52	187.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24FQH@186801|Clostridia,3WIDZ@541000|Ruminococcaceae	186801|Clostridia	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
GNS2_k127_3073773_21	161156.JQKW01000006_gene1360	3.881e-25	117.0	COG0469@1|root,COG0469@2|Bacteria,2GH3P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
GNS2_k127_3073773_12	1321784.HMPREF1987_00562	3.716e-64	227.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,25QD0@186804|Peptostreptococcaceae	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
GNS2_k127_3073773_8	573.JG24_18900	9.892e-76	265.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	yfhA	GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
GNS2_k127_3073773_10	468059.AUHA01000006_gene2918	3.488e-71	255.0	COG0477@1|root,COG2814@2|Bacteria,4PI8D@976|Bacteroidetes,1IY4H@117747|Sphingobacteriia	976|Bacteroidetes	EGP	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
GNS2_k127_3073773_9	216432.CA2559_09183	1.024e-72	253.0	COG2220@1|root,COG2220@2|Bacteria,4NFJ4@976|Bacteroidetes,1HYS8@117743|Flavobacteriia	976|Bacteroidetes	S	of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
GNS2_k127_3073773_19	1463934.JOCF01000022_gene6273	6.554e-34	144.0	2EUIU@1|root,33N0V@2|Bacteria,2HZ4V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_3073773_14	326427.Cagg_0668	2.347e-46	181.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	200795|Chloroflexi	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
GNS2_k127_3073773_24	883096.HMPREF9699_00313	7.867e-12	77.0	COG3677@1|root,COG3677@2|Bacteria,4NPDE@976|Bacteroidetes,1I5ER@117743|Flavobacteriia	976|Bacteroidetes	L	Protein involved in DNA binding, transposase activity and transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,Transposase_mut
GNS2_k127_3073773_16	1499967.BAYZ01000116_gene3145	7.831e-41	160.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
GNS2_k127_3073773_20	1410608.JNKX01000030_gene171	4.548e-29	128.0	COG2843@1|root,COG2843@2|Bacteria,4NI9W@976|Bacteroidetes,2G384@200643|Bacteroidia,4AWBI@815|Bacteroidaceae	976|Bacteroidetes	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
GNS2_k127_3073773_28	59926.EV02_1772	5.398e-09	60.0	COG4095@1|root,COG4095@2|Bacteria,1G874@1117|Cyanobacteria,1MMV6@1212|Prochloraceae	1117|Cyanobacteria	S	Alternative locus ID	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	PQ-loop
GNS2_k127_3073773_18	1217710.F969_00216	1.989e-35	147.0	COG1555@1|root,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
GNS2_k127_3073773_7	1123376.AUIU01000016_gene320	1.295e-83	307.0	COG4694@1|root,COG4694@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13
GNS2_k127_3073773_4	1121937.AUHJ01000024_gene66	3.788e-110	384.0	COG1061@1|root,COG1061@2|Bacteria,1MX92@1224|Proteobacteria,1RYDV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	type iii restriction	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
GNS2_k127_3073773_0	616991.JPOO01000001_gene3369	1.471e-177	570.0	COG2189@1|root,COG2189@2|Bacteria,4NFKE@976|Bacteroidetes,1HYXQ@117743|Flavobacteriia	976|Bacteroidetes	L	DNA methylase	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
GNS2_k127_3073773_25	350688.Clos_1826	1.315e-11	75.0	28KEB@1|root,2ZA0K@2|Bacteria,1V14E@1239|Firmicutes,25K6P@186801|Clostridia,36PDM@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_3073773_11	1437425.CSEC_0908	9.398e-71	259.0	COG1961@1|root,COG1961@2|Bacteria,2JGRW@204428|Chlamydiae	204428|Chlamydiae	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase,Zn_ribbon_recom
GNS2_k127_3073773_22	1293048.CBMB010000004_gene1743	1.021e-18	92.0	COG3217@1|root,arCOG04766@2157|Archaea,2Y7HS@28890|Euryarchaeota,241HM@183963|Halobacteria	183963|Halobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
GNS2_k127_3073773_6	1541960.KQ78_00792	5.206e-108	363.0	COG0442@1|root,COG0442@2|Bacteria,3WV4I@544448|Tenericutes	544448|Tenericutes	J	Anticodon binding domain	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
GNS2_k127_3073773_5	1304880.JAGB01000004_gene1402	6.112e-110	365.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
GNS2_k127_3073773_3	316274.Haur_0632	5.114e-119	395.0	COG0343@1|root,COG0343@2|Bacteria,2G5RE@200795|Chloroflexi,3752Z@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
GNS2_k127_3073773_1	1297742.A176_01364	2.89e-141	472.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
GNS2_k127_3073773_29	1163407.UU7_09957	3.934e-05	46.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1X4G1@135614|Xanthomonadales	135614|Xanthomonadales	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
GNS2_k127_3095881_2	335543.Sfum_2358	2.412e-07	62.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	2.4.1.52	ko:K00712	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	DUF285,Glycos_transf_1,MORN_2
GNS2_k127_3095881_1	317936.Nos7107_0713	1.121e-17	91.0	2CCI4@1|root,30BPJ@2|Bacteria,1GAR7@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_3095881_0	648757.Rvan_1379	1.277e-73	258.0	COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,2V700@28211|Alphaproteobacteria,3N8NH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Herpes_Helicase,PIF1
GNS2_k127_3176522_30	272563.CD630_18240	8.741e-06	49.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
GNS2_k127_3176522_15	1463853.JOHW01000024_gene4627	1.54e-58	218.0	COG5438@1|root,COG5438@2|Bacteria,2GKJ4@201174|Actinobacteria	201174|Actinobacteria	S	YibE F family protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
GNS2_k127_3176522_24	379066.GAU_3762	7.677e-20	101.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,YadA_head
GNS2_k127_3176522_11	1052684.PPM_2142	9.928e-76	264.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,4H9UN@91061|Bacilli,26RT6@186822|Paenibacillaceae	91061|Bacilli	P	Belongs to the bacterial solute-binding protein 9 family	adcA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZinT,ZnuA
GNS2_k127_3176522_8	398511.BpOF4_13815	2.908e-81	277.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,4HAZI@91061|Bacilli,1ZBS5@1386|Bacillus	91061|Bacilli	P	'COG1121 ABC-type Mn Zn transport systems, ATPase component'	zurA	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
GNS2_k127_3176522_14	580331.Thit_0320	4.909e-63	225.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,42FT2@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM ABC-3 protein	adcB	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
GNS2_k127_3176522_25	767817.Desgi_3280	1.677e-19	93.0	COG0735@1|root,COG0735@2|Bacteria,1V6RI@1239|Firmicutes,24PHW@186801|Clostridia,265NI@186807|Peptococcaceae	186801|Clostridia	P	Belongs to the Fur family	-	-	-	ko:K02076,ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
GNS2_k127_3176522_17	926692.AZYG01000085_gene807	6.201e-49	184.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WAJK@53433|Halanaerobiales	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
GNS2_k127_3176522_23	696369.KI912183_gene1409	3.887e-28	118.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,26201@186807|Peptococcaceae	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
GNS2_k127_3176522_28	667014.Thein_1722	3.111e-08	57.0	COG0333@1|root,COG0333@2|Bacteria,2GI2S@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
GNS2_k127_3176522_19	926569.ANT_22610	1.29e-37	154.0	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
GNS2_k127_3176522_0	269799.Gmet_0891	4.981e-236	751.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,43UAK@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
GNS2_k127_3176522_9	1128421.JAGA01000003_gene3142	6.812e-79	276.0	COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria	2|Bacteria	LU	DNA recombination-mediator protein A	dprA	-	5.99.1.2	ko:K03168,ko:K04096	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_processg_A
GNS2_k127_3176522_18	441768.ACL_0019	6.491e-42	160.0	COG0193@1|root,COG0193@2|Bacteria,3WT8R@544448|Tenericutes	544448|Tenericutes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
GNS2_k127_3176522_4	273068.TTE1619	5.155e-100	342.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,42F2X@68295|Thermoanaerobacterales	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
GNS2_k127_3176522_20	479434.Sthe_2301	2.241e-33	146.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,27XRZ@189775|Thermomicrobia	189775|Thermomicrobia	K	cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
GNS2_k127_3176522_1	485913.Krac_3454	1.03e-185	597.0	COG0441@1|root,COG0441@2|Bacteria,2G5PZ@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
GNS2_k127_3176522_12	1382306.JNIM01000001_gene4129	5.239e-73	256.0	COG0324@1|root,COG0324@2|Bacteria,2G5S7@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
GNS2_k127_3176522_22	926550.CLDAP_22720	5.958e-29	135.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
GNS2_k127_3176522_7	105559.Nwat_2363	1.249e-82	287.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,1RUDN@1236|Gammaproteobacteria,1WZ03@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
GNS2_k127_3176522_31	247490.KSU1_D0903	4.813e-05	55.0	COG0535@1|root,COG0535@2|Bacteria,2J2UG@203682|Planctomycetes	203682|Planctomycetes	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
GNS2_k127_3176522_26	311402.Avi_0393	3.85e-10	70.0	COG0500@1|root,COG2226@2|Bacteria,1RITQ@1224|Proteobacteria,2UAXV@28211|Alphaproteobacteria,4BFHZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
GNS2_k127_3176522_16	635013.TherJR_2843	6.832e-56	210.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,262C0@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
GNS2_k127_3176522_5	926561.KB900617_gene2076	1.206e-99	337.0	COG0438@1|root,COG0438@2|Bacteria,1TQN3@1239|Firmicutes,24ARN@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
GNS2_k127_3176522_13	926550.CLDAP_04540	1.854e-70	256.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G66B@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
GNS2_k127_3176522_6	479434.Sthe_3421	1.451e-84	293.0	COG1052@1|root,COG1052@2|Bacteria,2G6NV@200795|Chloroflexi	200795|Chloroflexi	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic region	-	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GNS2_k127_3176522_2	562970.Btus_1570	5.986e-162	530.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,4HAAP@91061|Bacilli,277WB@186823|Alicyclobacillaceae	91061|Bacilli	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
GNS2_k127_3176522_10	926569.ANT_11300	2.569e-78	286.0	COG0747@1|root,COG0747@2|Bacteria,2G5NC@200795|Chloroflexi	200795|Chloroflexi	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
GNS2_k127_3176522_27	255470.cbdbA1641	1.373e-08	58.0	COG1314@1|root,COG1314@2|Bacteria,2G7D9@200795|Chloroflexi,34DHN@301297|Dehalococcoidia	301297|Dehalococcoidia	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
GNS2_k127_3176522_21	1201288.M900_A0031	6.55e-33	136.0	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
GNS2_k127_3176522_3	1382356.JQMP01000004_gene366	6.799e-125	417.0	COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,27XGQ@189775|Thermomicrobia	189775|Thermomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	-
GNS2_k127_3404414_3	765420.OSCT_1873	4.177e-38	147.0	COG0691@1|root,COG0691@2|Bacteria,2G6NE@200795|Chloroflexi,375K8@32061|Chloroflexia	32061|Chloroflexia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
GNS2_k127_3404414_4	197221.22295345	1.059e-28	122.0	COG0290@1|root,COG0290@2|Bacteria,1G0WC@1117|Cyanobacteria	1117|Cyanobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
GNS2_k127_3404414_14	1034345.CAEM01000023_gene846	4.934e-05	48.0	COG0291@1|root,COG0291@2|Bacteria,2HV94@201174|Actinobacteria,4CWHW@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
GNS2_k127_3404414_5	1158292.JPOE01000002_gene1834	5.325e-26	111.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,1KKVN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
GNS2_k127_3404414_13	1530186.JQEY01000003_gene2300	4.291e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2U6J3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	MA20_09680	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
GNS2_k127_3404414_9	983544.Lacal_1976	1.45e-10	69.0	COG1595@1|root,COG1595@2|Bacteria,4NQTP@976|Bacteroidetes,1HYYI@117743|Flavobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GNS2_k127_3404414_2	391625.PPSIR1_21429	3.856e-57	212.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42QZQ@68525|delta/epsilon subdivisions,2WMV8@28221|Deltaproteobacteria,2YVB0@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
GNS2_k127_3404414_11	666686.B1NLA3E_18885	1.46e-07	55.0	COG1910@1|root,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,4HAJV@91061|Bacilli,1ZC11@1386|Bacillus	91061|Bacilli	P	COG1910 Periplasmic molybdate-binding protein domain	-	-	-	ko:K07219	-	-	-	-	ko00000	-	-	-	HTH_17,HTH_3,PBP_like
GNS2_k127_3404414_6	350688.Clos_1826	1.667e-19	99.0	28KEB@1|root,2ZA0K@2|Bacteria,1V14E@1239|Firmicutes,25K6P@186801|Clostridia,36PDM@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_3404414_15	1121451.DESAM_20046	0.0001565	53.0	28J6X@1|root,2Z92E@2|Bacteria,1R426@1224|Proteobacteria,42NPX@68525|delta/epsilon subdivisions,2WMA7@28221|Deltaproteobacteria,2MD13@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_3404414_1	402612.FP1947	1.286e-99	334.0	28I7Z@1|root,2Z8AU@2|Bacteria,4NXGP@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_3404414_0	402612.FP1949	3.637e-220	696.0	COG5293@1|root,COG5293@2|Bacteria,4P0PX@976|Bacteroidetes	976|Bacteroidetes	S	Uncharacterised protein conserved in bacteria (DUF2326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2326
GNS2_k127_3404414_8	746697.Aeqsu_2451	1.81e-11	74.0	2BYFR@1|root,32R3B@2|Bacteria,4P4QR@976|Bacteroidetes,1I9Y2@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_3404414_10	1248760.ANFZ01000024_gene1688	1.764e-10	72.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,2K148@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
GNS2_k127_3710656_1	945713.IALB_2995	3.587e-11	77.0	COG4288@1|root,COG4288@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Big_5,CHU_C,FlgD_ig,LTD
GNS2_k127_3710656_2	886882.PPSC2_c2424	4.77e-08	66.0	COG2374@1|root,COG2755@1|root,COG4085@1|root,COG2374@2|Bacteria,COG2755@2|Bacteria,COG4085@2|Bacteria,1TSI3@1239|Firmicutes,4HAWG@91061|Bacilli,26QIC@186822|Paenibacillaceae	91061|Bacilli	E	lipolytic protein G-D-S-L family	yhcR	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux,ChitinaseA_N
GNS2_k127_3710656_0	1353529.M899_0973	3.35e-64	226.0	COG0778@1|root,COG0778@2|Bacteria,1N95W@1224|Proteobacteria,42RYF@68525|delta/epsilon subdivisions,2MSXA@213481|Bdellovibrionales,2WRFC@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Nitroreductase family	-	-	1.5.1.34	ko:K10679	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
GNS2_k127_4172807_3	555088.DealDRAFT_1131	1.899e-110	372.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,42JIA@68298|Syntrophomonadaceae	186801|Clostridia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
GNS2_k127_4172807_7	1009370.ALO_20917	5.867e-43	161.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4H4A5@909932|Negativicutes	909932|Negativicutes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
GNS2_k127_4172807_4	667014.Thein_0441	1.552e-68	243.0	COG0275@1|root,COG0275@2|Bacteria,2GH39@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
GNS2_k127_4172807_2	1211817.CCAT010000006_gene1178	1.51e-130	451.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,36DF4@31979|Clostridiaceae	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
GNS2_k127_4172807_6	696281.Desru_3648	3.484e-48	186.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,260WC@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 4	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
GNS2_k127_4172807_12	1227487.C474_12511	8.843e-15	80.0	COG1430@1|root,arCOG03116@2157|Archaea,2XXGG@28890|Euryarchaeota,23VUJ@183963|Halobacteria	183963|Halobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
GNS2_k127_4172807_9	469381.Dpep_2146	1.596e-23	102.0	COG0261@1|root,COG0261@2|Bacteria,3TBBY@508458|Synergistetes	508458|Synergistetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
GNS2_k127_4172807_5	86416.Clopa_0105	3.549e-52	190.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,36EFC@31979|Clostridiaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
GNS2_k127_4172807_13	768670.Calni_1373	5.756e-06	52.0	COG0718@1|root,COG0718@2|Bacteria,2GFU9@200930|Deferribacteres	200930|Deferribacteres	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
GNS2_k127_4172807_0	525904.Tter_1815	1.559e-143	469.0	COG0305@1|root,COG0305@2|Bacteria,2NNKG@2323|unclassified Bacteria	2|Bacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
GNS2_k127_4172807_8	1094980.Mpsy_0080	4.72e-34	135.0	COG0537@1|root,arCOG00419@2157|Archaea,2XXWC@28890|Euryarchaeota,2NBIU@224756|Methanomicrobia	224756|Methanomicrobia	F	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
GNS2_k127_4172807_10	292563.Cyast_0198	1.718e-21	101.0	COG0494@1|root,COG0494@2|Bacteria,1G22W@1117|Cyanobacteria	1117|Cyanobacteria	L	Nudix hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
GNS2_k127_4172807_1	1047013.AQSP01000118_gene1252	1.11e-135	456.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4172807_11	436308.Nmar_0298	5.611e-18	88.0	arCOG03272@1|root,arCOG03272@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4199938_28	443598.AUFA01000021_gene2994	3.488e-12	68.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2TRMU@28211|Alphaproteobacteria,3JV8C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	NU	General secretion pathway protein E (Type II traffic warden ATPase)	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
GNS2_k127_4199938_1	273068.TTE1492	1.829e-178	582.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,42ES5@68295|Thermoanaerobacterales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
GNS2_k127_4199938_5	411468.CLOSCI_04076	5.47e-132	434.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,21XPS@1506553|Lachnoclostridium	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
GNS2_k127_4199938_22	56110.Oscil6304_2532	5.756e-20	98.0	COG1651@1|root,COG1651@2|Bacteria,1G379@1117|Cyanobacteria,1H9GF@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
GNS2_k127_4199938_36	379066.GAU_1942	0.0003117	53.0	COG0823@1|root,COG0823@2|Bacteria,1ZTBK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
GNS2_k127_4199938_2	309799.DICTH_1370	1.635e-176	582.0	COG0542@1|root,COG0542@2|Bacteria	2|Bacteria	O	response to heat	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
GNS2_k127_4199938_6	1128421.JAGA01000002_gene209	6.327e-119	397.0	COG1109@1|root,COG1109@2|Bacteria,2NNRE@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
GNS2_k127_4199938_10	1047013.AQSP01000139_gene2394	1.477e-77	269.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
GNS2_k127_4199938_12	717231.Flexsi_0881	1.515e-53	194.0	COG1704@1|root,COG1704@2|Bacteria,2GFE4@200930|Deferribacteres	200930|Deferribacteres	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
GNS2_k127_4199938_13	309799.DICTH_0638	1.584e-47	186.0	COG0750@1|root,COG0750@2|Bacteria	2|Bacteria	M	metalloendopeptidase activity	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	3.4.21.107,3.4.21.116	ko:K04771,ko:K06399,ko:K11749,ko:K16922	ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Peptidase_M50,Peptidase_S55
GNS2_k127_4199938_7	1195236.CTER_2542	9.484e-110	364.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
GNS2_k127_4199938_3	857293.CAAU_0666	3.147e-153	513.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,36DSY@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
GNS2_k127_4199938_0	525904.Tter_1074	9.655e-303	965.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
GNS2_k127_4199938_9	768710.DesyoDRAFT_0592	2.214e-86	298.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,260QV@186807|Peptococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
GNS2_k127_4199938_32	46234.ANA_C11833	2.539e-07	61.0	COG1404@1|root,COG2931@1|root,COG4733@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	1.11.1.5	ko:K00428,ko:K11005	-	-	-	-	ko00000,ko01000,ko02000,ko02042	1.C.11	-	-	CarboxypepD_reg,HemolysinCabind,SLH
GNS2_k127_4199938_25	264732.Moth_2126	1.699e-13	79.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,42FJS@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
GNS2_k127_4199938_16	767817.Desgi_3048	5.285e-37	149.0	COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,24DII@186801|Clostridia,261JP@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
GNS2_k127_4199938_18	1276756.AUEX01000008_gene3281	3.472e-30	127.0	2C6BU@1|root,32S87@2|Bacteria,1NIFE@1224|Proteobacteria,2VRGB@28216|Betaproteobacteria,4AGT5@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4199938_35	759914.BP951000_1745	0.0002051	52.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448,ko:K07273	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_2,Amidase_3,Cu_amine_oxidN1,GBS_Bsp-like
GNS2_k127_4199938_30	685778.AORL01000019_gene1855	7.082e-10	61.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4199938_26	1449063.JMLS01000022_gene6504	5.49e-13	77.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4HB9Q@91061|Bacilli,26SER@186822|Paenibacillaceae	91061|Bacilli	D	membrane	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
GNS2_k127_4199938_24	1304874.JAFY01000001_gene2615	1.942e-14	87.0	COG1470@1|root,COG3210@1|root,COG1470@2|Bacteria,COG3210@2|Bacteria,3TB3U@508458|Synergistetes	508458|Synergistetes	U	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
GNS2_k127_4199938_14	886293.Sinac_7212	8.015e-44	183.0	COG1572@1|root,COG1749@1|root,COG5306@1|root,COG1572@2|Bacteria,COG1749@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	N	bacterial-type flagellum-dependent cell motility	flgK	-	3.4.14.5	ko:K01278,ko:K02388,ko:K02396,ko:K03561,ko:K12287	ko02040,ko04974,map02040,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02035,ko02044,ko04090,ko04147	1.A.30.2.1	-	-	CHU_C,DUF2341,Flg_bb_rod,Flg_bbr_C,Laminin_G_3,MotA_ExbB
GNS2_k127_4199938_19	1123368.AUIS01000004_gene119	2.217e-28	119.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,1S3IM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
GNS2_k127_4199938_21	1301100.HG529431_gene1803	5.705e-21	95.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,36KID@31979|Clostridiaceae	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
GNS2_k127_4199938_4	1069080.KB913028_gene1442	2.536e-139	458.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,4H2T2@909932|Negativicutes	909932|Negativicutes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
GNS2_k127_4199938_29	2850.Phatr43976	4.718e-11	70.0	2CY44@1|root,2S1W5@2759|Eukaryota,2XB4Z@2836|Bacillariophyta	2836|Bacillariophyta	S	Translin family	-	-	-	-	-	-	-	-	-	-	-	-	Translin
GNS2_k127_4199938_11	1128421.JAGA01000002_gene1414	4.673e-77	274.0	COG0769@1|root,COG0769@2|Bacteria,2NNZM@2323|unclassified Bacteria	2|Bacteria	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.10,6.3.2.13	ko:K01928,ko:K15792	ko00300,ko00550,map00300,map00550	-	R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
GNS2_k127_4199938_34	696369.KI912183_gene2337	5.265e-05	51.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
GNS2_k127_4199938_20	1151292.QEW_2798	1.205e-22	110.0	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,25RN1@186804|Peptostreptococcaceae	186801|Clostridia	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N_3
GNS2_k127_4199938_31	102125.Xen7305DRAFT_00002820	9.634e-10	69.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,Collagen_bind,DUF11,Gram_pos_anchor,SdrD_B
GNS2_k127_4199938_27	926550.CLDAP_04950	2.095e-12	76.0	COG3764@1|root,COG3764@2|Bacteria,2G77W@200795|Chloroflexi	200795|Chloroflexi	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
GNS2_k127_4199938_33	796606.BMMGA3_08360	1.976e-06	58.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,4ISYS@91061|Bacilli,1ZRH6@1386|Bacillus	91061|Bacilli	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
GNS2_k127_4199938_23	388413.ALPR1_00005	1.667e-17	97.0	COG2931@1|root,COG3209@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF4347,PKD,SdrD_B
GNS2_k127_4199938_15	1123389.ATXJ01000004_gene1227	3.566e-42	158.0	COG1225@1|root,COG1225@2|Bacteria,1WI9E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
GNS2_k127_4209221_37	1121324.CLIT_13c01620	7.244e-13	73.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,25TA3@186804|Peptostreptococcaceae	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
GNS2_k127_4209221_39	313606.M23134_08426	5.194e-10	69.0	COG4123@1|root,COG4123@2|Bacteria,4NQKD@976|Bacteroidetes,47RIZ@768503|Cytophagia	976|Bacteroidetes	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
GNS2_k127_4209221_9	665571.STHERM_c04540	2.248e-109	368.0	COG0707@1|root,COG0707@2|Bacteria,2J9T2@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4209221_4	760142.Hipma_0827	1.987e-188	600.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
GNS2_k127_4209221_45	428125.CLOLEP_00924	4.313e-05	48.0	COG1476@1|root,COG1476@2|Bacteria,1VICZ@1239|Firmicutes,24S9J@186801|Clostridia,3WMP7@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
GNS2_k127_4209221_14	1122172.KB890272_gene137	9.423e-73	256.0	COG0338@1|root,COG3392@1|root,COG0338@2|Bacteria,COG3392@2|Bacteria,37BTI@32066|Fusobacteria	32066|Fusobacteria	H	Site-specific DNA-methyltransferase (Adenine-specific)	dam	-	2.1.1.72	ko:K06223,ko:K07318	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
GNS2_k127_4209221_12	1244531.CIG1485E_0237	6.263e-84	289.0	COG3392@1|root,COG3392@2|Bacteria,1R84X@1224|Proteobacteria,42NGF@68525|delta/epsilon subdivisions,2YNT0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
GNS2_k127_4209221_36	279010.BL02333	1.715e-16	93.0	COG3183@1|root,COG3183@2|Bacteria,1VHD5@1239|Firmicutes,4IQ0M@91061|Bacilli,1ZHRI@1386|Bacillus	91061|Bacilli	V	HNH endonuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3578,HNH
GNS2_k127_4209221_15	592029.DDD_3604	1.847e-67	239.0	COG0322@1|root,COG0322@2|Bacteria,4NHBM@976|Bacteroidetes,1I0MC@117743|Flavobacteriia	976|Bacteroidetes	L	Domain of unknown function (DUF4357)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4357,GIY-YIG
GNS2_k127_4209221_25	700598.Niako_1369	2.736e-29	122.0	28PTP@1|root,2ZCEW@2|Bacteria,4NN9M@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4209221_44	999541.bgla_1g17370	4.299e-06	53.0	COG0640@1|root,COG0640@2|Bacteria,1N10H@1224|Proteobacteria,2VUMP@28216|Betaproteobacteria,1K8ZS@119060|Burkholderiaceae	28216|Betaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
GNS2_k127_4209221_17	196162.Noca_4855	4.338e-57	206.0	COG1388@1|root,COG1388@2|Bacteria,2IKMC@201174|Actinobacteria	201174|Actinobacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4209221_7	261292.Nit79A3_3156	6.493e-123	412.0	COG1858@1|root,COG1858@2|Bacteria,1REQ9@1224|Proteobacteria	1224|Proteobacteria	P	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
GNS2_k127_4209221_22	485913.Krac_4700	1.149e-41	165.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4209221_13	485918.Cpin_2002	2.369e-81	287.0	COG2239@1|root,COG2239@2|Bacteria,4NGGN@976|Bacteroidetes,1IPNC@117747|Sphingobacteriia	976|Bacteroidetes	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
GNS2_k127_4209221_19	751944.HALDL1_16645	5.152e-44	167.0	arCOG00346@1|root,arCOG00346@2157|Archaea,2XU0A@28890|Euryarchaeota,23V08@183963|Halobacteria	183963|Halobacteria	S	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
GNS2_k127_4209221_1	7955.ENSDARP00000122475	5.703e-234	751.0	COG0308@1|root,KOG1046@2759|Eukaryota,38CFG@33154|Opisthokonta,3BADC@33208|Metazoa,3CW5S@33213|Bilateria,486H0@7711|Chordata,48VUN@7742|Vertebrata,4A251@7898|Actinopterygii	33208|Metazoa	O	Aminopeptidase puromycin sensitive	NPEPPS	GO:0000003,GO:0000209,GO:0000578,GO:0000793,GO:0000922,GO:0001666,GO:0003002,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0006464,GO:0006508,GO:0006518,GO:0006807,GO:0006950,GO:0007049,GO:0007275,GO:0007350,GO:0007351,GO:0007389,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008595,GO:0009056,GO:0009628,GO:0009790,GO:0009792,GO:0009798,GO:0009880,GO:0009948,GO:0009952,GO:0009987,GO:0010564,GO:0010720,GO:0015630,GO:0016567,GO:0016787,GO:0019538,GO:0022402,GO:0022414,GO:0030588,GO:0030590,GO:0032446,GO:0032501,GO:0032502,GO:0033218,GO:0033554,GO:0034641,GO:0035282,GO:0036211,GO:0036293,GO:0036294,GO:0042221,GO:0042277,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043603,GO:0043900,GO:0043902,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0044770,GO:0044771,GO:0045595,GO:0045597,GO:0046662,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048856,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050896,GO:0051094,GO:0051179,GO:0051235,GO:0051239,GO:0051240,GO:0051321,GO:0051445,GO:0051640,GO:0051641,GO:0051642,GO:0051651,GO:0051657,GO:0051661,GO:0051716,GO:0051726,GO:0060281,GO:0060282,GO:0060284,GO:0061842,GO:0065007,GO:0065008,GO:0070006,GO:0070011,GO:0070482,GO:0070647,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0072686,GO:0097431,GO:0140096,GO:1900193,GO:1900195,GO:1901564,GO:1901565,GO:1901575,GO:1903046,GO:1903429,GO:1903431,GO:1903538,GO:1905879,GO:1905881,GO:1990947,GO:2000241,GO:2000243	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
GNS2_k127_4209221_29	140626.JHWB01000022_gene2081	4.819e-25	111.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
GNS2_k127_4209221_5	436114.SYO3AOP1_0570	6.198e-141	471.0	COG0532@1|root,COG0532@2|Bacteria,2G3W1@200783|Aquificae	200783|Aquificae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
GNS2_k127_4209221_23	1191523.MROS_0287	5.063e-37	142.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
GNS2_k127_4209221_0	1336241.JAEB01000028_gene1220	2.521e-248	809.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,25V0K@186806|Eubacteriaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
GNS2_k127_4209221_20	255470.cbdbA29	6.23e-44	179.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2G6G7@200795|Chloroflexi,34CYA@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Domain of unknown function (DUF4131)	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
GNS2_k127_4209221_35	887929.HMP0721_1574	6.011e-17	88.0	COG0500@1|root,COG2226@2|Bacteria,1UVT3@1239|Firmicutes,25B9E@186801|Clostridia,25ZRM@186806|Eubacteriaceae	186801|Clostridia	H	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
GNS2_k127_4209221_21	748727.CLJU_c06590	1.474e-42	167.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,36DFY@31979|Clostridiaceae	186801|Clostridia	L	domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
GNS2_k127_4209221_11	580327.Tthe_1412	1.663e-98	334.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,42EQU@68295|Thermoanaerobacterales	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
GNS2_k127_4209221_24	1449126.JQKL01000038_gene978	2.016e-31	133.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,267IV@186813|unclassified Clostridiales	186801|Clostridia	U	60Kd inner membrane protein	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
GNS2_k127_4209221_33	1237149.C900_03022	1.536e-20	103.0	COG1708@1|root,COG1708@2|Bacteria,4NPRU@976|Bacteroidetes	976|Bacteroidetes	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
GNS2_k127_4209221_41	309801.trd_0841	8.465e-08	64.0	COG3307@1|root,COG3307@2|Bacteria,2G6TE@200795|Chloroflexi,27XXU@189775|Thermomicrobia	189775|Thermomicrobia	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
GNS2_k127_4209221_30	580340.Tlie_0600	1.463e-22	100.0	COG0234@1|root,COG0234@2|Bacteria,3TBF2@508458|Synergistetes	508458|Synergistetes	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
GNS2_k127_4209221_2	373903.Hore_02010	1.877e-213	675.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WAF0@53433|Halanaerobiales	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
GNS2_k127_4209221_34	459349.CLOAM1068	1.164e-17	89.0	COG2426@1|root,COG2426@2|Bacteria,2NRIQ@2323|unclassified Bacteria	2|Bacteria	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
GNS2_k127_4209221_10	858215.Thexy_0660	4.261e-107	357.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,42EU5@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
GNS2_k127_4209221_27	243274.THEMA_00375	7.974e-28	121.0	COG0009@1|root,COG0009@2|Bacteria,2GCC7@200918|Thermotogae	200918|Thermotogae	H	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
GNS2_k127_4209221_40	661478.OP10G_2262	2.373e-08	60.0	COG1306@1|root,COG1306@2|Bacteria	2|Bacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
GNS2_k127_4209221_16	292459.STH1268	2.762e-57	209.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia	186801|Clostridia	M	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
GNS2_k127_4209221_18	796940.HMPREF9628_01335	5.952e-53	196.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,25QII@186804|Peptostreptococcaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
GNS2_k127_4209221_46	240016.ABIZ01000001_gene5499	0.000402	50.0	COG2931@1|root,COG3203@1|root,COG3266@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3203@2|Bacteria,COG3266@2|Bacteria,COG4932@2|Bacteria,46VKK@74201|Verrucomicrobia,2IW2X@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
GNS2_k127_4209221_43	1451261.AS96_14610	1.181e-06	63.0	COG3704@1|root,COG3704@2|Bacteria	2|Bacteria	U	protein secretion by the type IV secretion system	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
GNS2_k127_4209221_38	485913.Krac_5206	1.294e-10	70.0	COG3451@1|root,COG3451@2|Bacteria	2|Bacteria	U	multi-organism process	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
GNS2_k127_4209221_8	1068980.ARVW01000001_gene4278	2.644e-112	385.0	COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4E84C@85010|Pseudonocardiales	201174|Actinobacteria	U	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87
GNS2_k127_4209221_26	525904.Tter_1047	1.811e-28	123.0	COG1040@1|root,COG1040@2|Bacteria,2NPMC@2323|unclassified Bacteria	2|Bacteria	S	competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
GNS2_k127_4209221_31	83406.HDN1F_19930	8.442e-22	98.0	COG2151@1|root,COG2151@2|Bacteria,1NAVI@1224|Proteobacteria	1224|Proteobacteria	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
GNS2_k127_4209221_28	479434.Sthe_1526	2.04e-25	109.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi,27YGN@189775|Thermomicrobia	189775|Thermomicrobia	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
GNS2_k127_4209221_6	1379698.RBG1_1C00001G0739	2.914e-139	453.0	COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K04487,ko:K11717	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03599,R07460,R11528,R11529	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
GNS2_k127_4209221_32	663932.KB902575_gene2241	1.795e-21	102.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,2JPFV@204441|Rhodospirillales	204441|Rhodospirillales	O	Uncharacterized protein family (UPF0051)	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
GNS2_k127_4209221_3	530564.Psta_4543	3.562e-208	656.0	COG0719@1|root,COG0719@2|Bacteria,2IXZD@203682|Planctomycetes	203682|Planctomycetes	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
GNS2_k127_4209221_42	768679.TTX_0942	4.035e-07	52.0	COG0396@1|root,arCOG04236@2157|Archaea,2XQ7X@28889|Crenarchaeota	28889|Crenarchaeota	O	TIGRFAM FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
GNS2_k127_4299666_8	237368.SCABRO_00069	4.837e-31	123.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
GNS2_k127_4299666_4	469371.Tbis_1304	4.633e-41	166.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4DXM8@85010|Pseudonocardiales	201174|Actinobacteria	M	PFAM Glycosyl transferases group 1	pimB	-	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
GNS2_k127_4299666_10	1286106.MPL1_13117	2.748e-25	109.0	COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,1S8Z1@1236|Gammaproteobacteria,462MC@72273|Thiotrichales	72273|Thiotrichales	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
GNS2_k127_4299666_3	339860.Msp_0448	2.965e-42	173.0	COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota,23PBE@183925|Methanobacteria	183925|Methanobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
GNS2_k127_4299666_6	1179777.D500_0035	4.786e-34	135.0	COG0103@1|root,COG0103@2|Bacteria,3WTKX@544448|Tenericutes	544448|Tenericutes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
GNS2_k127_4299666_9	1286171.EAL2_c01920	3.361e-27	114.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,25WEH@186806|Eubacteriaceae	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
GNS2_k127_4299666_11	1267533.KB906735_gene5102	5.84e-23	102.0	COG0203@1|root,COG0203@2|Bacteria,3Y4JF@57723|Acidobacteria,2JJ8Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
GNS2_k127_4299666_0	1094508.Tsac_1040	1.808e-59	216.0	COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,42FI6@68295|Thermoanaerobacterales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
GNS2_k127_4299666_2	1121468.AUBR01000044_gene1834	1.066e-47	178.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,42ENH@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
GNS2_k127_4299666_5	1410630.JNKP01000006_gene182	5.406e-38	147.0	COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,27M7M@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
GNS2_k127_4299666_7	370438.PTH_0345	9.555e-34	133.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,261QX@186807|Peptococcaceae	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
GNS2_k127_4299666_13	642492.Clole_3521	7.45e-12	66.0	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
GNS2_k127_4299666_12	1333998.M2A_3022	1.006e-22	99.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,4BQNB@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
GNS2_k127_4299666_14	742726.HMPREF9448_01911	7.177e-08	59.0	COG2246@1|root,COG2246@2|Bacteria,4NXZ2@976|Bacteroidetes	976|Bacteroidetes	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
GNS2_k127_4299666_1	573413.Spirs_3146	3.385e-54	194.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
GNS2_k127_453184_1	555079.Toce_0259	1.558e-37	145.0	COG0122@1|root,COG0122@2|Bacteria,1V5KW@1239|Firmicutes,25BR2@186801|Clostridia	186801|Clostridia	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
GNS2_k127_453184_2	456442.Mboo_0011	2.674e-17	89.0	COG0580@1|root,arCOG04431@2157|Archaea,2XT1N@28890|Euryarchaeota,2N9IJ@224756|Methanomicrobia	224756|Methanomicrobia	G	TIGRFAM MIP family channel	aqpM	-	-	ko:K02440,ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2	-	-	MIP
GNS2_k127_453184_0	1184267.A11Q_2466	3.369e-76	267.0	COG4585@1|root,COG4585@2|Bacteria,1R9XM@1224|Proteobacteria	1224|Proteobacteria	T	STAS-like domain of unknown function (DUF4325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4325,HATPase_c_2
GNS2_k127_4690023_0	648757.Rvan_1379	6.534e-150	490.0	COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,2V700@28211|Alphaproteobacteria,3N8NH@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Helicase	-	-	-	-	-	-	-	-	-	-	-	-	Herpes_Helicase,PIF1
GNS2_k127_4690023_7	1408473.JHXO01000008_gene2691	2.748e-25	109.0	COG1186@1|root,COG1186@2|Bacteria,4NQ41@976|Bacteroidetes,2FY9G@200643|Bacteroidia	976|Bacteroidetes	J	RF-1 domain	arfB	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
GNS2_k127_4690023_2	316274.Haur_3122	1.496e-77	275.0	COG2133@1|root,COG2133@2|Bacteria,2G7VF@200795|Chloroflexi,377AV@32061|Chloroflexia	32061|Chloroflexia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
GNS2_k127_4690023_4	1205680.CAKO01000040_gene808	1.834e-42	163.0	2AY4N@1|root,31Q6J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4690023_3	574087.Acear_1277	6.886e-71	252.0	COG0616@1|root,COG0616@2|Bacteria,1U2Z9@1239|Firmicutes,24DAF@186801|Clostridia,3WC5D@53433|Halanaerobiales	186801|Clostridia	OU	Periplasmic serine protease	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
GNS2_k127_4690023_1	387093.SUN_0736	5.636e-108	359.0	COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,42MTT@68525|delta/epsilon subdivisions,2YNXI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Virulence protein RhuM family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Virulence_RhuM
GNS2_k127_4690023_5	1183377.Py04_1071	1.2e-30	125.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ89@28890|Euryarchaeota,244GY@183968|Thermococci	183968|Thermococci	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like,tRNA_edit
GNS2_k127_4690023_6	1173025.GEI7407_0964	4.194e-27	120.0	COG1216@1|root,COG1216@2|Bacteria,1G09N@1117|Cyanobacteria,1H8HE@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_2,Glycos_transf_2
GNS2_k127_4690023_8	237368.SCABRO_00069	2.951e-11	63.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
GNS2_k127_477076_1	796940.HMPREF9628_01672	2.869e-17	93.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,25TD1@186804|Peptostreptococcaceae	186801|Clostridia	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
GNS2_k127_477076_2	555079.Toce_0898	1.533e-06	53.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,42H31@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
GNS2_k127_477076_0	1047013.AQSP01000140_gene2513	3.457e-42	169.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
GNS2_k127_4771048_1	1535287.JP74_01095	7.572e-78	269.0	COG1215@1|root,COG1215@2|Bacteria,1RE2E@1224|Proteobacteria,2U721@28211|Alphaproteobacteria,3N7KK@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GNS2_k127_4771048_6	875454.BAEW01000001_gene212	5.198e-22	100.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,22HID@1570339|Peptoniphilaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
GNS2_k127_4771048_4	1047013.AQSP01000107_gene2079	4.447e-53	193.0	COG1432@1|root,COG1432@2|Bacteria,2NRX6@2323|unclassified Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
GNS2_k127_4771048_0	755731.Clo1100_2020	2.544e-205	662.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,36DDN@31979|Clostridiaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
GNS2_k127_4771048_2	1304284.L21TH_1610	1.82e-74	256.0	COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,24A3M@186801|Clostridia,36G9F@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD,dUTPase
GNS2_k127_4771048_7	1207076.ALAT01000216_gene4015	1.463e-07	60.0	2EH3G@1|root,33AVG@2|Bacteria,1NQ4B@1224|Proteobacteria,1SHSX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_4771048_3	1162668.LFE_1617	4.291e-55	205.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
GNS2_k127_4771048_5	700598.Niako_4015	8.122e-25	112.0	COG3428@1|root,COG3428@2|Bacteria,4P8QM@976|Bacteroidetes,1IZVT@117747|Sphingobacteriia	976|Bacteroidetes	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
GNS2_k127_4795226_13	1121011.AUCB01000019_gene3478	3.812e-10	72.0	COG2367@1|root,COG2367@2|Bacteria,4PDG3@976|Bacteroidetes,1I0I0@117743|Flavobacteriia,23I10@178469|Arenibacter	976|Bacteroidetes	V	Beta-lactamase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
GNS2_k127_4795226_4	68219.JNXI01000010_gene5787	2.806e-35	144.0	COG1651@1|root,COG1651@2|Bacteria,2GM6C@201174|Actinobacteria	201174|Actinobacteria	O	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
GNS2_k127_4795226_5	439292.Bsel_2577	7.357e-24	107.0	COG4243@1|root,COG4243@2|Bacteria	2|Bacteria	S	quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4,VKOR
GNS2_k127_4795226_0	1280666.ATVS01000068_gene2627	7.449e-138	448.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,4BX81@830|Butyrivibrio	186801|Clostridia	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
GNS2_k127_4795226_11	391612.CY0110_24581	1.785e-12	70.0	COG1872@1|root,COG1872@2|Bacteria,1G935@1117|Cyanobacteria,3KIWU@43988|Cyanothece	1117|Cyanobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
GNS2_k127_4795226_14	572479.Hprae_0263	1.349e-08	67.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,24AB7@186801|Clostridia,3WBJX@53433|Halanaerobiales	186801|Clostridia	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
GNS2_k127_4795226_6	401053.AciPR4_2987	2.547e-22	103.0	COG0494@1|root,COG0494@2|Bacteria,3Y4N9@57723|Acidobacteria,2JJ9X@204432|Acidobacteriia	204432|Acidobacteriia	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
GNS2_k127_4795226_15	1120949.KB903306_gene7432	2.915e-06	59.0	COG0741@1|root,COG0741@2|Bacteria,2I2XS@201174|Actinobacteria,4DAXN@85008|Micromonosporales	201174|Actinobacteria	M	Membrane-bound lytic murein transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,SLT_2
GNS2_k127_4795226_8	1121930.AQXG01000001_gene1488	3.192e-17	87.0	29E7I@1|root,3015I@2|Bacteria,4NNFG@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
GNS2_k127_4795226_2	575590.HMPREF0156_00092	1.682e-56	199.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
GNS2_k127_4795226_17	1117379.BABA_05941	0.0005348	52.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.4.14.10	ko:K01280	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
GNS2_k127_4795226_9	1499967.BAYZ01000016_gene6529	1.913e-13	82.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CW_binding_1,Flg_new,SLH
GNS2_k127_4795226_12	1499967.BAYZ01000080_gene910	1.514e-11	80.0	COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2NRZP@2323|unclassified Bacteria	2|Bacteria	M	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,ESPR,LVIVD,YadA_anchor,YadA_head,YadA_stalk
GNS2_k127_4795226_10	358681.BBR47_47230	3.85e-13	76.0	COG2223@1|root,COG2223@2|Bacteria,1TRS9@1239|Firmicutes,4HCY1@91061|Bacilli,26TC9@186822|Paenibacillaceae	91061|Bacilli	P	Nitrate nitrite transporter	narK	-	-	ko:K02575,ko:K10850	ko00910,ko02020,map00910,map02020	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1,PAS_9
GNS2_k127_4795226_1	192952.MM_2665	3.053e-67	235.0	COG1136@1|root,arCOG00922@2157|Archaea,2XWHK@28890|Euryarchaeota,2N9GX@224756|Methanomicrobia	224756|Methanomicrobia	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GNS2_k127_4795226_3	679926.Mpet_2614	6.25e-38	158.0	COG0577@1|root,arCOG02315@2157|Archaea,2XYJU@28890|Euryarchaeota,2N9SS@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
GNS2_k127_4795226_7	646529.Desaci_4382	1.867e-17	96.0	COG0845@1|root,COG0845@2|Bacteria,1UY0S@1239|Firmicutes,25CIV@186801|Clostridia,260HX@186807|Peptococcaceae	186801|Clostridia	M	Secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP
GNS2_k127_5341679_10	1379698.RBG1_1C00001G1752	9.883e-79	283.0	COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria	2|Bacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
GNS2_k127_5341679_1	246194.CHY_0410	3.985e-215	683.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,42F8U@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
GNS2_k127_5341679_6	316274.Haur_4833	5.869e-123	416.0	COG0608@1|root,COG0608@2|Bacteria,2G5US@200795|Chloroflexi,374UZ@32061|Chloroflexia	32061|Chloroflexia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
GNS2_k127_5341679_26	1487921.DP68_02840	0.000735	52.0	COG5513@1|root,COG5513@2|Bacteria,1V52X@1239|Firmicutes,25ER6@186801|Clostridia,36US0@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4163)	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF3298,DUF4163
GNS2_k127_5341679_19	479434.Sthe_0447	3.886e-22	106.0	COG0500@1|root,COG2226@2|Bacteria,2G780@200795|Chloroflexi,27XQ2@189775|Thermomicrobia	189775|Thermomicrobia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
GNS2_k127_5341679_16	869210.Marky_0734	1.126e-50	195.0	COG0438@1|root,COG0438@2|Bacteria,1WKWC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
GNS2_k127_5341679_23	868131.MSWAN_1280	4.056e-13	73.0	COG2456@1|root,arCOG05092@2157|Archaea,2XZCE@28890|Euryarchaeota,23P9R@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
GNS2_k127_5341679_15	1123278.KB893543_gene5469	5.22e-52	191.0	COG1216@1|root,COG1216@2|Bacteria,4NETR@976|Bacteroidetes,47MJC@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF2062,Glycos_transf_2
GNS2_k127_5341679_11	1410620.SHLA_61c000110	2.006e-71	253.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,4BA55@82115|Rhizobiaceae	28211|Alphaproteobacteria	GM	dTDP-glucose 4-6-dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
GNS2_k127_5341679_13	1123508.JH636444_gene5290	2.073e-65	243.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2IY4U@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
GNS2_k127_5341679_12	1121889.AUDM01000008_gene828	8.417e-66	242.0	COG2148@1|root,COG2148@2|Bacteria,4NFIA@976|Bacteroidetes,1HXE1@117743|Flavobacteriia,2NU1E@237|Flavobacterium	976|Bacteroidetes	M	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
GNS2_k127_5341679_3	1321779.HMPREF1984_01533	1.556e-159	519.0	COG0504@1|root,COG0504@2|Bacteria,378S0@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
GNS2_k127_5341679_20	349161.Dred_3303	1.089e-21	100.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,26287@186807|Peptococcaceae	186801|Clostridia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
GNS2_k127_5341679_14	580331.Thit_0922	1.041e-60	220.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,42EK1@68295|Thermoanaerobacterales	186801|Clostridia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
GNS2_k127_5341679_9	926569.ANT_12940	2.434e-81	286.0	COG0793@1|root,COG0793@2|Bacteria,2G6HR@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
GNS2_k127_5341679_5	1120917.AQXM01000061_gene1778	6.477e-125	413.0	COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,1W8KV@1268|Micrococcaceae	201174|Actinobacteria	KM	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
GNS2_k127_5341679_18	1144275.COCOR_06205	2.291e-31	128.0	COG0328@1|root,COG0328@2|Bacteria,1MZD1@1224|Proteobacteria,42UI6@68525|delta/epsilon subdivisions,2WQSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Ribonuclease H	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
GNS2_k127_5341679_8	1511.CLOST_1792	4.448e-102	344.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,25QX8@186804|Peptostreptococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
GNS2_k127_5341679_0	880073.Calab_2438	3.485e-244	769.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
GNS2_k127_5341679_22	349520.PPE_03216	4.832e-18	91.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,26X19@186822|Paenibacillaceae	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
GNS2_k127_5341679_21	1519464.HY22_12070	2.5e-19	96.0	COG1420@1|root,COG1420@2|Bacteria,1FDKF@1090|Chlorobi	1090|Chlorobi	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
GNS2_k127_5341679_24	1536774.H70357_30770	1.007e-06	57.0	COG0330@1|root,COG0330@2|Bacteria,1UZJK@1239|Firmicutes,4HGVU@91061|Bacilli,26RE7@186822|Paenibacillaceae	91061|Bacilli	O	HflC protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
GNS2_k127_5341679_25	1448857.JFAP01000006_gene170	3.371e-06	57.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2YMUQ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
GNS2_k127_5341679_4	263820.PTO1315	8.468e-140	455.0	COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,241PE@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
GNS2_k127_5341679_17	1177154.Y5S_00561	1.27e-40	164.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RP0T@1236|Gammaproteobacteria,1XJRK@135619|Oceanospirillales	135619|Oceanospirillales	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
GNS2_k127_5341679_7	65071.PYU1_T011594	4.137e-105	350.0	COG0042@1|root,KOG2335@2759|Eukaryota,1MFAE@121069|Pythiales	121069|Pythiales	J	TRNA-dihydrouridine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Dus
GNS2_k127_5341679_2	452637.Oter_3586	7.969e-198	625.0	COG1914@1|root,COG1914@2|Bacteria,46SH7@74201|Verrucomicrobia	74201|Verrucomicrobia	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
GNS2_k127_562994_1	224325.AF_0879	5.972e-73	258.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,245SV@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
GNS2_k127_562994_3	526222.Desal_3767	1.292e-32	134.0	COG1205@1|root,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2M8EC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase domain protein	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
GNS2_k127_562994_0	138119.DSY2426	1.761e-106	358.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25ZZ7@186807|Peptococcaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
GNS2_k127_562994_5	1121423.JONT01000007_gene502	5.458e-06	52.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,25CD2@186801|Clostridia	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
GNS2_k127_562994_4	243231.GSU3187	1.409e-12	69.0	COG1141@1|root,COG1141@2|Bacteria,1PZW5@1224|Proteobacteria,42WWZ@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Divergent 4Fe-4S mono-cluster	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
GNS2_k127_562994_2	1047013.AQSP01000139_gene2381	1.512e-40	153.0	COG0313@1|root,COG0313@2|Bacteria,2NP98@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
GNS2_k127_5747033_15	1095769.CAHF01000008_gene3628	0.0003156	48.0	COG0071@1|root,COG5637@1|root,COG0071@2|Bacteria,COG5637@2|Bacteria,1RCEX@1224|Proteobacteria,2VQP4@28216|Betaproteobacteria,4771P@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
GNS2_k127_5747033_4	518766.Rmar_0920	8.556e-71	244.0	COG0605@1|root,COG0605@2|Bacteria,4NDZ4@976|Bacteroidetes,1FJ6I@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
GNS2_k127_5747033_5	1293054.HSACCH_00330	1.119e-58	215.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,3WAJM@53433|Halanaerobiales	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
GNS2_k127_5747033_6	1089553.Tph_c12600	1.473e-58	220.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,42EWR@68295|Thermoanaerobacterales	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
GNS2_k127_5747033_2	525904.Tter_1614	2.617e-102	354.0	COG0768@1|root,COG0768@2|Bacteria,2NNWR@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding Protein dimerisation domain	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iSSON_1240.SSON_0092	PASTA,PBP_dimer,Transpeptidase
GNS2_k127_5747033_7	999630.TUZN_2170	2.959e-44	168.0	COG0105@1|root,arCOG04313@2157|Archaea,2XQEV@28889|Crenarchaeota	28889|Crenarchaeota	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
GNS2_k127_5747033_9	655811.HMPREF0078_1106	5.805e-16	81.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,22HTU@1570339|Peptoniphilaceae	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
GNS2_k127_5747033_10	224324.aq_1457	7.919e-16	85.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
GNS2_k127_5747033_13	926560.KE387023_gene2506	7.148e-10	69.0	2AYAM@1|root,33ACG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_5747033_14	102232.GLO73106DRAFT_00006390	6.12e-06	57.0	COG1597@1|root,COG1597@2|Bacteria,1G0MV@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
GNS2_k127_5747033_8	2325.TKV_c08660	1.041e-16	86.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,42GQS@68295|Thermoanaerobacterales	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
GNS2_k127_5747033_3	765869.BDW_07365	8.819e-98	340.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2MSNP@213481|Bdellovibrionales,2WKII@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
GNS2_k127_5747033_1	391009.Tmel_0177	3.42e-114	380.0	COG0162@1|root,COG0162@2|Bacteria,2GCKH@200918|Thermotogae	200918|Thermotogae	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iLJ478.TM0478	S4,tRNA-synt_1b
GNS2_k127_5747033_0	748449.Halha_2021	4.915e-209	680.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WA6Y@53433|Halanaerobiales	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
GNS2_k127_599490_1	717774.Marme_1338	1.52e-06	50.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1XI26@135619|Oceanospirillales	135619|Oceanospirillales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
GNS2_k127_599490_0	1307761.L21SP2_1037	3.356e-177	570.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
GNS2_k127_6336659_3	313596.RB2501_07415	9.972e-18	85.0	COG0313@1|root,COG0313@2|Bacteria,4NFQM@976|Bacteroidetes,1HX5Y@117743|Flavobacteriia	976|Bacteroidetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
GNS2_k127_6336659_0	1232410.KI421413_gene826	8.698e-136	448.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,43SAM@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Anticodon-binding domain of tRNA	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
GNS2_k127_6336659_6	537971.HCCG_01444	0.0001834	50.0	COG1286@1|root,COG1286@2|Bacteria,1NIBK@1224|Proteobacteria,42U0P@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Colicin V production protein	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
GNS2_k127_6336659_1	1000569.HMPREF1040_1172	7.349e-55	202.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4H2S5@909932|Negativicutes	909932|Negativicutes	L	hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
GNS2_k127_6336659_2	525904.Tter_0069	8.581e-47	178.0	COG0356@1|root,COG0356@2|Bacteria,2NPRQ@2323|unclassified Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
GNS2_k127_6336659_4	926550.CLDAP_05100	1.731e-11	67.0	COG0636@1|root,COG0636@2|Bacteria,2G72D@200795|Chloroflexi	200795|Chloroflexi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
GNS2_k127_6336659_5	1123070.KB899254_gene1167	1.566e-10	66.0	COG0711@1|root,COG0711@2|Bacteria,46SYI@74201|Verrucomicrobia,2IUEN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	ATP synthase B/B' CF(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
GNS2_k127_6337773_2	56780.SYN_00207	2.504e-86	297.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,2MRZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
GNS2_k127_6337773_6	290317.Cpha266_2438	2.61e-11	76.0	COG2244@1|root,COG2244@2|Bacteria,1FEUS@1090|Chlorobi	1090|Chlorobi	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
GNS2_k127_6337773_3	502025.Hoch_1846	3.409e-18	90.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKJ7@28221|Deltaproteobacteria,2Z0RB@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
GNS2_k127_6337773_4	720554.Clocl_2405	1.094e-14	85.0	COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,24CYM@186801|Clostridia,3WJIR@541000|Ruminococcaceae	186801|Clostridia	D	stage II sporulation protein	lytB	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	PG_binding_1,SpoIID,Y_Y_Y
GNS2_k127_6337773_1	373903.Hore_12310	7.024e-127	415.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3WACV@53433|Halanaerobiales	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
GNS2_k127_6337773_0	479434.Sthe_2363	0.0	1399.0	COG0209@1|root,COG0209@2|Bacteria,2G8RN@200795|Chloroflexi,27Y2V@189775|Thermomicrobia	189775|Thermomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
GNS2_k127_6337773_5	1242864.D187_000457	1.08e-11	65.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,42TN4@68525|delta/epsilon subdivisions,2WQ0Q@28221|Deltaproteobacteria,2YVM4@29|Myxococcales	28221|Deltaproteobacteria	S	Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
GNS2_k127_633966_0	1408306.JHXX01000006_gene965	1.258e-32	133.0	COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,4BZ96@830|Butyrivibrio	186801|Clostridia	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
GNS2_k127_633966_4	1043493.BBLU01000001_gene1055	6.824e-07	60.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria	201174|Actinobacteria	L	RecB family exonuclease	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
GNS2_k127_633966_3	661478.OP10G_4295	3.365e-07	63.0	COG4934@1|root,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_S8,Pro-kuma_activ
GNS2_k127_633966_1	497965.Cyan7822_2518	1.099e-21	113.0	COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1GQ6Z@1117|Cyanobacteria,3KK0X@43988|Cyanothece	1117|Cyanobacteria	Q	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
GNS2_k127_6481213_8	1120965.AUBV01000014_gene1189	4.377e-13	74.0	COG1216@1|root,COG1216@2|Bacteria,4NQF8@976|Bacteroidetes,47XHZ@768503|Cytophagia	976|Bacteroidetes	S	Glycosyltransferase like family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
GNS2_k127_6481213_4	1303518.CCALI_01017	7.57e-36	147.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
GNS2_k127_6481213_6	935845.JADQ01000028_gene584	2.758e-34	145.0	COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,4HQF6@91061|Bacilli,26THF@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
GNS2_k127_6481213_2	945713.IALB_0746	3.177e-46	178.0	COG1086@1|root,COG1216@1|root,COG2148@1|root,COG1086@2|Bacteria,COG1216@2|Bacteria,COG2148@2|Bacteria	2|Bacteria	M	undecaprenyl-phosphate glucose phosphotransferase activity	wbbL	-	-	ko:K03606,ko:K07011	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
GNS2_k127_6481213_5	1121285.AUFK01000012_gene1863	1.049e-35	139.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1I2SV@117743|Flavobacteriia,3ZS3U@59732|Chryseobacterium	976|Bacteroidetes	J	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
GNS2_k127_6481213_3	1379698.RBG1_1C00001G1620	4.577e-46	180.0	COG2222@1|root,COG2222@2|Bacteria,2NQVV@2323|unclassified Bacteria	2|Bacteria	M	Bacterial phospho-glucose isomerase C-terminal SIS domain	pgi	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
GNS2_k127_6481213_9	304371.MCP_0072	2.917e-09	66.0	COG1418@1|root,arCOG01860@2157|Archaea,2XSXG@28890|Euryarchaeota,2NA06@224756|Methanomicrobia	224756|Methanomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
GNS2_k127_6481213_1	1347369.CCAD010000082_gene2663	3.468e-57	209.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,4HBXF@91061|Bacilli,1ZBZD@1386|Bacillus	91061|Bacilli	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
GNS2_k127_6481213_7	1122225.AULQ01000009_gene364	5.709e-17	85.0	COG0662@1|root,COG0662@2|Bacteria,4NQ4K@976|Bacteroidetes,1I2VJ@117743|Flavobacteriia	976|Bacteroidetes	G	domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FdtA
GNS2_k127_6481213_0	868595.Desca_2613	5.864e-122	400.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia,26192@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
GNS2_k127_6481213_10	1120972.AUMH01000015_gene1353	5.139e-09	57.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4HAEV@91061|Bacilli	91061|Bacilli	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
GNS2_k127_6500583_15	1379698.RBG1_1C00001G1014	2.499e-19	91.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	2.1.1.63,3.2.2.21	ko:K00567,ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
GNS2_k127_6500583_3	913865.DOT_0412	1.504e-94	319.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,261UF@186807|Peptococcaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
GNS2_k127_6500583_0	767817.Desgi_4193	4.228e-247	782.0	COG4640@1|root,COG4640@2|Bacteria,1TQ9M@1239|Firmicutes,24DDM@186801|Clostridia,264D0@186807|Peptococcaceae	186801|Clostridia	S	DUF3160	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160,zinc_ribbon_2
GNS2_k127_6500583_1	767817.Desgi_4194	6.314e-148	486.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,2676Q@186807|Peptococcaceae	186801|Clostridia	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,Peptidase_M15
GNS2_k127_6500583_11	317013.NY99_01925	3.468e-38	150.0	COG4995@1|root,COG4995@2|Bacteria,1RIFF@1224|Proteobacteria,1SMET@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
GNS2_k127_6500583_10	316274.Haur_4061	1.42e-38	163.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G8PA@200795|Chloroflexi,376UG@32061|Chloroflexia	32061|Chloroflexia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
GNS2_k127_6500583_16	521011.Mpal_0877	9.851e-19	94.0	COG0642@1|root,arCOG06192@2157|Archaea	521011.Mpal_0877|-	T	TIGRFAM PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_6500583_13	1034943.BN1094_02754	4.056e-36	139.0	COG3070@1|root,COG3070@2|Bacteria,1N0ND@1224|Proteobacteria,1SE8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Regulator of competence-specific genes	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
GNS2_k127_6500583_5	103690.17130869	1.943e-77	271.0	COG0189@1|root,COG0189@2|Bacteria,1GBE8@1117|Cyanobacteria,1HJ35@1161|Nostocales	1117|Cyanobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	-	-	-	-	-	-	-	-	-	-	RimK
GNS2_k127_6500583_6	491916.RHECIAT_CH0002830	4.31e-59	209.0	COG0251@1|root,COG0251@2|Bacteria,1NX10@1224|Proteobacteria,2VCFZ@28211|Alphaproteobacteria,4B8GQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
GNS2_k127_6500583_2	347834.RHE_CH02692	5.692e-118	383.0	COG1028@1|root,COG1028@2|Bacteria,1NQPQ@1224|Proteobacteria,2VF6E@28211|Alphaproteobacteria,4BN7C@82115|Rhizobiaceae	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
GNS2_k127_6500583_9	1071679.BG57_03250	9.07e-41	159.0	29J25@1|root,305ZK@2|Bacteria,1RBIY@1224|Proteobacteria,2VTA2@28216|Betaproteobacteria,1K67W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
GNS2_k127_6500583_19	1336245.JAGO01000011_gene252	0.0001178	46.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria,1XIAW@135619|Oceanospirillales	135619|Oceanospirillales	O	Glutathione S-transferase, C-terminal domain	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_3,GST_N
GNS2_k127_6500583_12	1419583.V466_22670	1.492e-37	145.0	COG1733@1|root,COG1733@2|Bacteria,1R6HM@1224|Proteobacteria,1SEM2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
GNS2_k127_6500583_14	313603.FB2170_15693	2.052e-31	126.0	COG3324@1|root,COG3324@2|Bacteria,4NMFV@976|Bacteroidetes,1IGP1@117743|Flavobacteriia,2PITX@252356|Maribacter	976|Bacteroidetes	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
GNS2_k127_6500583_4	1191523.MROS_1554	1.056e-86	297.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	-	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
GNS2_k127_6500583_17	1120985.AUMI01000011_gene597	2.413e-15	86.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1UZKB@1239|Firmicutes,4H7EG@909932|Negativicutes	909932|Negativicutes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
GNS2_k127_6500583_8	386456.JQKN01000002_gene2764	1.574e-55	198.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota	28890|Euryarchaeota	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	tspO	GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
GNS2_k127_6500583_18	1408813.AYMG01000038_gene275	2.206e-12	71.0	COG4469@1|root,COG4469@2|Bacteria,4P4EP@976|Bacteroidetes	976|Bacteroidetes	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	CoiA
GNS2_k127_6654178_1	765420.OSCT_0770	2.276e-08	66.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
GNS2_k127_6654178_0	176946.XP_007433077.1	1.287e-09	72.0	COG0457@1|root,KOG2003@2759|Eukaryota,38B6J@33154|Opisthokonta,3BB9Q@33208|Metazoa,3CR5Z@33213|Bilateria,480R4@7711|Chordata,496CC@7742|Vertebrata	33208|Metazoa	S	regulation of autophagosome assembly	IFT88	GO:0000003,GO:0000226,GO:0000902,GO:0000904,GO:0001578,GO:0001654,GO:0001655,GO:0001669,GO:0001822,GO:0001885,GO:0001886,GO:0001889,GO:0001944,GO:0002064,GO:0002080,GO:0002081,GO:0002119,GO:0002164,GO:0003002,GO:0003006,GO:0003007,GO:0003008,GO:0003158,GO:0003205,GO:0003206,GO:0003279,GO:0003382,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005813,GO:0005814,GO:0005815,GO:0005856,GO:0005929,GO:0005930,GO:0006810,GO:0006928,GO:0006950,GO:0006970,GO:0006996,GO:0006997,GO:0007010,GO:0007017,GO:0007018,GO:0007154,GO:0007165,GO:0007166,GO:0007219,GO:0007224,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007288,GO:0007289,GO:0007290,GO:0007368,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0007507,GO:0007600,GO:0007605,GO:0007610,GO:0007626,GO:0008092,GO:0008104,GO:0008150,GO:0008283,GO:0008285,GO:0008544,GO:0008589,GO:0009628,GO:0009653,GO:0009790,GO:0009791,GO:0009799,GO:0009855,GO:0009887,GO:0009888,GO:0009894,GO:0009952,GO:0009953,GO:0009966,GO:0009967,GO:0009987,GO:0010468,GO:0010506,GO:0010646,GO:0010647,GO:0010970,GO:0012505,GO:0012506,GO:0014706,GO:0015630,GO:0016020,GO:0016043,GO:0016241,GO:0019222,GO:0019894,GO:0019953,GO:0021510,GO:0021511,GO:0021513,GO:0021537,GO:0022008,GO:0022412,GO:0022414,GO:0022603,GO:0022607,GO:0022611,GO:0023051,GO:0023052,GO:0023056,GO:0030030,GO:0030031,GO:0030141,GO:0030154,GO:0030162,GO:0030182,GO:0030317,GO:0030323,GO:0030324,GO:0030326,GO:0030659,GO:0030667,GO:0030705,GO:0030855,GO:0030900,GO:0030990,GO:0030992,GO:0031016,GO:0031090,GO:0031122,GO:0031175,GO:0031323,GO:0031329,GO:0031344,GO:0031410,GO:0031503,GO:0031514,GO:0031982,GO:0031984,GO:0032101,GO:0032103,GO:0032391,GO:0032421,GO:0032501,GO:0032502,GO:0032504,GO:0032838,GO:0032989,GO:0032991,GO:0033036,GO:0033043,GO:0034405,GO:0035051,GO:0035082,GO:0035107,GO:0035108,GO:0035113,GO:0035295,GO:0035640,GO:0035641,GO:0035735,GO:0035869,GO:0036064,GO:0036334,GO:0040011,GO:0040012,GO:0040017,GO:0040024,GO:0042073,GO:0042127,GO:0042481,GO:0042487,GO:0042490,GO:0042592,GO:0042692,GO:0042733,GO:0042995,GO:0043005,GO:0043053,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043567,GO:0043568,GO:0043583,GO:0044085,GO:0044087,GO:0044088,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044431,GO:0044433,GO:0044441,GO:0044444,GO:0044446,GO:0044447,GO:0044450,GO:0044463,GO:0044464,GO:0044703,GO:0044782,GO:0045446,GO:0045595,GO:0045598,GO:0046907,GO:0048232,GO:0048468,GO:0048513,GO:0048515,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048645,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048732,GO:0048736,GO:0048738,GO:0048839,GO:0048853,GO:0048854,GO:0048856,GO:0048869,GO:0048870,GO:0048872,GO:0050678,GO:0050680,GO:0050789,GO:0050793,GO:0050794,GO:0050795,GO:0050877,GO:0050896,GO:0050920,GO:0050921,GO:0050954,GO:0051128,GO:0051146,GO:0051171,GO:0051179,GO:0051234,GO:0051239,GO:0051246,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0051716,GO:0055007,GO:0055115,GO:0060021,GO:0060091,GO:0060113,GO:0060119,GO:0060122,GO:0060173,GO:0060255,GO:0060259,GO:0060271,GO:0060322,GO:0060411,GO:0060426,GO:0060429,GO:0060491,GO:0060537,GO:0060541,GO:0060914,GO:0061008,GO:0061061,GO:0061351,GO:0065007,GO:0065008,GO:0070613,GO:0070925,GO:0071840,GO:0072001,GO:0072358,GO:0072359,GO:0080090,GO:0090102,GO:0097014,GO:0097223,GO:0097435,GO:0097458,GO:0097541,GO:0097542,GO:0097546,GO:0097708,GO:0097722,GO:0097730,GO:0097731,GO:0097732,GO:0097733,GO:0098588,GO:0098589,GO:0098791,GO:0098805,GO:0098862,GO:0099111,GO:0099503,GO:0099568,GO:0120025,GO:0120031,GO:0120032,GO:0120035,GO:0120036,GO:0120038,GO:1902017,GO:1902115,GO:1903317,GO:1903929,GO:1905515,GO:2000026,GO:2000027,GO:2000785	-	ko:K16474	-	-	-	-	ko00000,ko03036	-	-	-	TPR_1,TPR_12,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
GNS2_k127_6704569_2	561177.ANHYDRO_00628	5.945e-55	207.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,22GNJ@1570339|Peptoniphilaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
GNS2_k127_6704569_0	1009370.ALO_07018	9.047e-181	586.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,4H2PQ@909932|Negativicutes	909932|Negativicutes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
GNS2_k127_6704569_3	266117.Rxyl_0038	0.0002496	52.0	2DFV5@1|root,2ZT9W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_6704569_1	648996.Theam_0511	1.135e-102	354.0	COG2804@1|root,COG2804@2|Bacteria,2G3UR@200783|Aquificae	200783|Aquificae	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
GNS2_k127_6878441_1	700598.Niako_4539	7.793e-75	258.0	COG2834@1|root,COG2834@2|Bacteria,4NFGN@976|Bacteroidetes,1ISK8@117747|Sphingobacteriia	976|Bacteroidetes	M	outer membrane lipoprotein carrier protein LolA	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA,LolA_2
GNS2_k127_6878441_0	28072.Nos7524_0911	1.011e-91	317.0	COG3385@1|root,COG3385@2|Bacteria,1G3D9@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind
GNS2_k127_6878441_2	485918.Cpin_3659	1.553e-46	175.0	2DP10@1|root,3302V@2|Bacteria,4PMCJ@976|Bacteroidetes,1J0N4@117747|Sphingobacteriia	976|Bacteroidetes	S	START domain	-	-	-	-	-	-	-	-	-	-	-	-	START
GNS2_k127_6878441_3	1123248.KB893326_gene1334	3.005e-12	66.0	COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1IRBM@117747|Sphingobacteriia	976|Bacteroidetes	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
GNS2_k127_698965_20	65093.PCC7418_0376	9.817e-14	75.0	COG1209@1|root,COG1209@2|Bacteria,1G091@1117|Cyanobacteria	1117|Cyanobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
GNS2_k127_698965_19	1370121.AUWS01000089_gene4809	4.116e-21	97.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
GNS2_k127_698965_26	747365.Thena_1320	1.013e-06	52.0	COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,42HIJ@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
GNS2_k127_698965_10	289376.THEYE_A1736	3.812e-40	156.0	COG1994@1|root,COG1994@2|Bacteria,3J14Q@40117|Nitrospirae	40117|Nitrospirae	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
GNS2_k127_698965_15	1123368.AUIS01000001_gene1866	1.37e-26	112.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,1SIID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
GNS2_k127_698965_8	158190.SpiGrapes_2766	3.037e-55	201.0	COG0528@1|root,COG0528@2|Bacteria,2J5H9@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
GNS2_k127_698965_13	720554.Clocl_0653	3.712e-33	134.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3WIH7@541000|Ruminococcaceae	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
GNS2_k127_698965_9	938288.HG326225_gene1061	7.351e-41	154.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,269AI@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
GNS2_k127_698965_29	765420.OSCT_2950	0.0003371	54.0	COG0631@1|root,COG0631@2|Bacteria,2G72P@200795|Chloroflexi,374Z2@32061|Chloroflexia	32061|Chloroflexia	T	protein serine/threonine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_698965_22	1304874.JAFY01000002_gene1073	2.375e-12	75.0	COG0640@1|root,COG0640@2|Bacteria,3TAVK@508458|Synergistetes	508458|Synergistetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_698965_28	985762.SAGN_11795	0.0001486	49.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4HHD7@91061|Bacilli,4GY01@90964|Staphylococcaceae	91061|Bacilli	O	Glycoprotease family	yeaZ	GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
GNS2_k127_698965_6	585530.HMPREF0183_0154	2.038e-56	215.0	COG1215@1|root,COG1215@2|Bacteria,2IK1V@201174|Actinobacteria,4F9BY@85019|Brevibacteriaceae	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_698965_14	1382306.JNIM01000001_gene2933	6.221e-31	138.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
GNS2_k127_698965_4	626939.HMPREF9443_00952	4.723e-114	377.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,4H1XS@909932|Negativicutes	909932|Negativicutes	D	Cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
GNS2_k127_698965_12	1121428.DESHY_50066___1	7.725e-39	158.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,260MY@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
GNS2_k127_698965_17	1128427.KB904821_gene2484	1.072e-21	98.0	COG0642@1|root,COG0745@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,1G1M7@1117|Cyanobacteria,1H7YE@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,STAS
GNS2_k127_698965_18	1123508.JH636439_gene1485	1.747e-21	105.0	COG2812@1|root,COG2812@2|Bacteria,2J4XP@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
GNS2_k127_698965_16	1499967.BAYZ01000195_gene3091	2.038e-24	115.0	COG4447@1|root,COG4447@2|Bacteria,2NQ6W@2323|unclassified Bacteria	2|Bacteria	S	Por secretion system C-terminal sorting domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,Sortilin-Vps10
GNS2_k127_698965_11	1121413.JMKT01000008_gene1645	2.711e-39	153.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2M8XC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
GNS2_k127_698965_3	269800.Tfu_0861	3.417e-157	508.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4EI01@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
GNS2_k127_698965_5	1304284.L21TH_1345	1.134e-77	275.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,36DH6@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
GNS2_k127_698965_7	1499967.BAYZ01000069_gene1882	5.937e-56	204.0	COG0149@1|root,COG0149@2|Bacteria,2NP24@2323|unclassified Bacteria	2|Bacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
GNS2_k127_698965_24	65393.PCC7424_2942	2.859e-11	74.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1GIT8@1117|Cyanobacteria,3KHZU@43988|Cyanothece	1117|Cyanobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_2,TPR_8,Trypsin_2
GNS2_k127_698965_27	118161.KB235922_gene2614	2.032e-05	48.0	2DTFP@1|root,33K5P@2|Bacteria,1GAV7@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_698965_25	879305.HMPREF9290_0539	7.529e-07	52.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,22HQV@1570339|Peptoniphilaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
GNS2_k127_698965_21	639282.DEFDS_0358	9.076e-13	70.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
GNS2_k127_698965_1	760142.Hipma_0827	3.816e-187	600.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
GNS2_k127_698965_23	216432.CA2559_04285	1.38e-11	67.0	COG1396@1|root,COG1396@2|Bacteria,4NY63@976|Bacteroidetes,1IJFC@117743|Flavobacteriia	976|Bacteroidetes	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
GNS2_k127_698965_2	1211817.CCAT010000067_gene467	3.611e-162	566.0	COG0714@1|root,COG1112@1|root,COG0714@2|Bacteria,COG1112@2|Bacteria,1TP20@1239|Firmicutes,24BMH@186801|Clostridia,36GFE@31979|Clostridiaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF3320,DUF4011,DUF559
GNS2_k127_698965_0	926562.Oweho_0531	3.027e-194	614.0	COG4487@1|root,COG4487@2|Bacteria,4NFX1@976|Bacteroidetes,1HY62@117743|Flavobacteriia,2PBC0@246874|Cryomorphaceae	976|Bacteroidetes	S	protein conserved in bacteria (DUF2130)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
GNS2_k127_6997941_4	1191523.MROS_0743	1.497e-30	127.0	COG0632@1|root,COG0632@2|Bacteria	2|Bacteria	L	four-way junction helicase activity	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
GNS2_k127_6997941_1	525904.Tter_0314	1.679e-113	380.0	COG0165@1|root,COG0165@2|Bacteria,2NP70@2323|unclassified Bacteria	2|Bacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Lyase_1
GNS2_k127_6997941_2	1123508.JH636440_gene2322	3.346e-84	290.0	COG0402@1|root,COG0402@2|Bacteria,2J1ZA@203682|Planctomycetes	203682|Planctomycetes	F	MGS-like domain	-	-	-	-	-	-	-	-	-	-	-	-	MGS
GNS2_k127_6997941_3	1307759.JOMJ01000004_gene2781	3.505e-57	211.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,42MXZ@68525|delta/epsilon subdivisions,2WJWG@28221|Deltaproteobacteria,2MANP@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
GNS2_k127_6997941_0	635013.TherJR_0872	2.14e-123	413.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,260XG@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
GNS2_k127_7003164_23	1254432.SCE1572_36665	1.376e-34	139.0	COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,431RV@68525|delta/epsilon subdivisions,2WWFG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
GNS2_k127_7003164_26	309799.DICTH_1320	1.336e-21	100.0	COG2236@1|root,COG2236@2|Bacteria	2|Bacteria	F	xanthine phosphoribosyltransferase activity	gpt	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
GNS2_k127_7003164_18	880073.Calab_0976	7.419e-45	175.0	COG0697@1|root,COG0697@2|Bacteria,2NQTD@2323|unclassified Bacteria	2|Bacteria	EG	EamA-like transporter family	yoaV3	-	-	-	-	-	-	-	-	-	-	-	EamA
GNS2_k127_7003164_32	5762.XP_002682248.1	6.902e-09	59.0	28KN3@1|root,2QT3M@2759|Eukaryota	2759|Eukaryota	S	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
GNS2_k127_7003164_5	1406840.Q763_06000	2.05e-105	361.0	COG0531@1|root,COG0531@2|Bacteria,4NHS2@976|Bacteroidetes,1HX4J@117743|Flavobacteriia,2NTH2@237|Flavobacterium	976|Bacteroidetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
GNS2_k127_7003164_10	1234364.AMSF01000088_gene2702	2.473e-68	243.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1X31S@135614|Xanthomonadales	135614|Xanthomonadales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
GNS2_k127_7003164_20	1122135.KB893157_gene358	3.729e-39	155.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	transport, permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
GNS2_k127_7003164_19	264462.Bd3594	8.351e-40	155.0	COG0625@1|root,COG0625@2|Bacteria,1PEUK@1224|Proteobacteria,437SY@68525|delta/epsilon subdivisions,2MUK6@213481|Bdellovibrionales,2X324@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
GNS2_k127_7003164_25	264462.Bd1337	3.917e-25	107.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,430NN@68525|delta/epsilon subdivisions,2MT6T@213481|Bdellovibrionales,2WVYS@28221|Deltaproteobacteria	213481|Bdellovibrionales	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
GNS2_k127_7003164_15	330214.NIDE4248	4.953e-54	201.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
GNS2_k127_7003164_4	1379698.RBG1_1C00001G1680	3.502e-141	460.0	COG0513@1|root,COG0513@2|Bacteria,2NP0A@2323|unclassified Bacteria	2|Bacteria	JKL	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
GNS2_k127_7003164_11	926560.KE387023_gene1627	5.267e-63	220.0	COG0225@1|root,COG0225@2|Bacteria,1WK2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
GNS2_k127_7003164_14	35754.JNYJ01000065_gene5760	3.617e-54	195.0	COG1435@1|root,COG1435@2|Bacteria,2HU8R@201174|Actinobacteria,4DCUA@85008|Micromonosporales	201174|Actinobacteria	F	Thymidine kinase	-	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
GNS2_k127_7003164_1	635013.TherJR_2771	6.12e-285	902.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,260C9@186807|Peptococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
GNS2_k127_7003164_24	626887.J057_08051	4.85e-27	111.0	COG4728@1|root,COG4728@2|Bacteria,1N6NP@1224|Proteobacteria,1SCKQ@1236|Gammaproteobacteria,468GN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1653
GNS2_k127_7003164_8	756067.MicvaDRAFT_3896	4.176e-83	298.0	COG0342@1|root,COG0342@2|Bacteria,1G053@1117|Cyanobacteria,1H7U4@1150|Oscillatoriales	1117|Cyanobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
GNS2_k127_7003164_13	309801.trd_0649	6.843e-58	213.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi,27Y1D@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
GNS2_k127_7003164_9	598659.NAMH_0757	1.091e-72	254.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2YM9U@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
GNS2_k127_7003164_16	1403819.BATR01000098_gene3226	2.131e-52	194.0	COG0500@1|root,COG2226@2|Bacteria,46Z32@74201|Verrucomicrobia,2IUX9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
GNS2_k127_7003164_7	926561.KB900617_gene2311	3.578e-96	335.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,3WAIF@53433|Halanaerobiales	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
GNS2_k127_7003164_6	1047013.AQSP01000118_gene1252	7.164e-99	353.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_7003164_21	1128421.JAGA01000002_gene104	1.687e-36	150.0	COG0598@1|root,COG0598@2|Bacteria,2NQIW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
GNS2_k127_7003164_12	1499967.BAYZ01000039_gene2222	1.696e-62	222.0	COG0558@1|root,COG0558@2|Bacteria,2NPXW@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.34	ko:K07291	ko00562,map00562	-	R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
GNS2_k127_7003164_2	515635.Dtur_1693	1.304e-180	576.0	COG0215@1|root,COG0215@2|Bacteria	2|Bacteria	J	cysteine-tRNA ligase activity	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
GNS2_k127_7003164_28	439235.Dalk_0477	1.277e-17	95.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
GNS2_k127_7003164_27	1380394.JADL01000020_gene1815	6.128e-21	96.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2JPZV@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
GNS2_k127_7003164_31	639282.DEFDS_1270	3.591e-11	69.0	COG4969@1|root,COG4969@2|Bacteria,2GG2G@200930|Deferribacteres	200930|Deferribacteres	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
GNS2_k127_7003164_22	1047013.AQSP01000066_gene719	5.768e-35	143.0	COG1989@1|root,COG1989@2|Bacteria,2NPDS@2323|unclassified Bacteria	2|Bacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02236,ko:K02278,ko:K02506,ko:K02654,ko:K10966	-	M00331,M00429	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
GNS2_k127_7003164_3	945713.IALB_0373	1.798e-166	547.0	COG0272@1|root,COG0272@2|Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972,ko:K10754	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	M00289,M00295	R00382	RC00005	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
GNS2_k127_7003164_0	1173025.GEI7407_1688	3.38e-304	961.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1G0GP@1117|Cyanobacteria,1H9GG@1150|Oscillatoriales	1117|Cyanobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
GNS2_k127_7003164_17	565033.GACE_2148	1.04e-50	188.0	COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota,246ZF@183980|Archaeoglobi	183980|Archaeoglobi	P	PFAM zinc iron permease	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
GNS2_k127_7003164_34	416591.Tlet_1726	0.0003865	49.0	2BH23@1|root,32B2N@2|Bacteria,2GD3A@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_7003164_33	1125971.ASJB01000042_gene3472	3.481e-07	59.0	2FC0A@1|root,3444I@2|Bacteria,2IT3Q@201174|Actinobacteria,4EBU3@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_7003164_30	1304284.L21TH_0458	5.501e-12	69.0	COG5460@1|root,COG5460@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2164
GNS2_k127_7068606_0	596315.HMPREF0634_0941	1.299e-204	656.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,25QWZ@186804|Peptostreptococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
GNS2_k127_7171174_1	1127673.GLIP_1607	3.843e-28	121.0	2CHG4@1|root,32WRW@2|Bacteria,1N300@1224|Proteobacteria,1SGD1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_7171174_0	1211777.BN77_2484	2.219e-51	184.0	2C8CT@1|root,315IS@2|Bacteria,1R3CJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863
GNS2_k127_7171174_4	1410631.JHWZ01000002_gene1309	0.0009972	48.0	2DM6X@1|root,31ZD1@2|Bacteria,1UKWZ@1239|Firmicutes,24JDU@186801|Clostridia,27UIF@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
GNS2_k127_7171174_2	1123376.AUIU01000016_gene285	5.817e-17	81.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	hipB	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0001666,GO:0002682,GO:0002683,GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006109,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016070,GO:0018130,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019438,GO:0022611,GO:0030162,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0032774,GO:0032879,GO:0032880,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0035821,GO:0036293,GO:0040007,GO:0040008,GO:0042176,GO:0043170,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045824,GO:0045892,GO:0045893,GO:0045926,GO:0045927,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050708,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051171,GO:0051172,GO:0051173,GO:0051223,GO:0051246,GO:0051252,GO:0051253,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0090087,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903507,GO:1903508,GO:1903530,GO:1990837,GO:2000112,GO:2000113,GO:2001141	1.1.1.100,2.1.1.72,2.3.1.1,2.5.1.7,2.7.7.9,3.1.21.4,3.4.21.88,3.5.1.1	ko:K00059,ko:K00790,ko:K00963,ko:K01155,ko:K01356,ko:K01424,ko:K02806,ko:K03427,ko:K07075,ko:K14682,ko:K15546,ko:K15773,ko:K18831,ko:K19417,ko:K19449,ko:K20391,ko:K22299	ko00040,ko00052,ko00061,ko00220,ko00250,ko00333,ko00460,ko00500,ko00520,ko00550,ko00780,ko01040,ko01100,ko01110,ko01130,ko01210,ko01212,ko01230,ko02024,ko02060,map00040,map00052,map00061,map00220,map00250,map00333,map00460,map00500,map00520,map00550,map00780,map01040,map01100,map01110,map01130,map01210,map01212,map01230,map02024,map02060	M00028,M00083,M00129,M00361,M00362,M00549,M00572,M00729	R00259,R00289,R00485,R00660,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00002,RC00004,RC00010,RC00029,RC00064,RC00117,RC00350,RC02798	ko00000,ko00001,ko00002,ko01000,ko01002,ko01004,ko01011,ko02000,ko02048,ko03000,ko03400	-	-	-	HTH_3,HTH_31
GNS2_k127_7512444_20	498761.HM1_2316	3.367e-22	106.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia	186801|Clostridia	J	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
GNS2_k127_7512444_3	697303.Thewi_1686	4.974e-160	520.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,42FP5@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
GNS2_k127_7512444_5	269797.Mbar_A2222	1.011e-134	446.0	COG0696@1|root,arCOG03068@2157|Archaea,2XTUA@28890|Euryarchaeota,2NA9Z@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
GNS2_k127_7512444_4	1120980.JQKH01000008_gene2139	1.259e-141	460.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,2KPTJ@206351|Neisseriales	206351|Neisseriales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
GNS2_k127_7512444_19	1535287.JP74_06965	2.123e-26	119.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,3N6Z2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF541)	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
GNS2_k127_7512444_10	1123252.ATZF01000013_gene2749	2.014e-91	314.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,27BKM@186824|Thermoactinomycetaceae	91061|Bacilli	G	Phosphoglycerate kinase	pgk	GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04145	PGK
GNS2_k127_7512444_18	1072685.IX83_02960	1.258e-26	121.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,3T1YA@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
GNS2_k127_7512444_23	1123376.AUIU01000012_gene1600	1.201e-20	98.0	COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
GNS2_k127_7512444_17	1410633.JHWR01000002_gene2019	1.509e-27	121.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,27IYU@186928|unclassified Lachnospiraceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
GNS2_k127_7512444_7	326427.Cagg_3070	1.388e-133	439.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi,374WK@32061|Chloroflexia	32061|Chloroflexia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
GNS2_k127_7512444_8	309799.DICTH_1453	1.499e-111	369.0	COG0057@1|root,COG0057@2|Bacteria	2|Bacteria	G	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
GNS2_k127_7512444_6	909663.KI867150_gene1155	3.734e-134	439.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42M7K@68525|delta/epsilon subdivisions,2WKKM@28221|Deltaproteobacteria,2MRBF@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95,Methyltrans_SAM,Methyltransf_25
GNS2_k127_7512444_11	986075.CathTA2_0724	1.708e-86	294.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4HBDV@91061|Bacilli	91061|Bacilli	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
GNS2_k127_7512444_12	944480.ATUV01000001_gene520	1.2e-67	239.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2M6ET@213113|Desulfurellales	28221|Deltaproteobacteria	J	Ribosomal protein S2	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
GNS2_k127_7512444_21	1410653.JHVC01000002_gene4184	3.781e-22	98.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,36KES@31979|Clostridiaceae	186801|Clostridia	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
GNS2_k127_7512444_9	429009.Adeg_0063	1.318e-110	369.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
GNS2_k127_7512444_25	349124.Hhal_1555	1.22e-07	64.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142,PMT_2
GNS2_k127_7512444_16	246194.CHY_2562	3.454e-40	160.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,42F18@68295|Thermoanaerobacterales	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
GNS2_k127_7512444_15	1286171.EAL2_c07660	2.844e-49	189.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia,25VD7@186806|Eubacteriaceae	186801|Clostridia	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
GNS2_k127_7512444_22	1072685.IX83_03380	4.304e-21	102.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,3T3I4@506|Alcaligenaceae	28216|Betaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
GNS2_k127_7512444_13	1122609.AUGT01000005_gene1638	1.235e-66	240.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4DN3V@85009|Propionibacteriales	201174|Actinobacteria	D	Cell cycle protein	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
GNS2_k127_7512444_14	572547.Amico_1001	6.278e-59	219.0	COG0322@1|root,COG0322@2|Bacteria,3TA9X@508458|Synergistetes	508458|Synergistetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
GNS2_k127_7512444_26	472759.Nhal_1552	6.412e-07	57.0	2C578@1|root,32RF7@2|Bacteria,1NCG3@1224|Proteobacteria,1STJE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Immunoglobulin-like domain of bacterial spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_7512444_0	511051.CSE_15640	6.467e-298	936.0	COG0178@1|root,COG0178@2|Bacteria	2|Bacteria	L	nucleotide-excision repair	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
GNS2_k127_7512444_1	1303518.CCALI_00921	9.179e-218	692.0	COG0556@1|root,COG0556@2|Bacteria	2|Bacteria	L	nucleotide-excision repair	uvrB	-	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
GNS2_k127_7512444_24	867845.KI911784_gene1388	2.906e-16	86.0	COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi,375G8@32061|Chloroflexia	32061|Chloroflexia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
GNS2_k127_7512444_2	525904.Tter_1067	2.962e-204	650.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
GNS2_k127_7860568_0	1408324.JNJK01000031_gene3556	6.8e-07	64.0	COG4548@1|root,COG4548@2|Bacteria,1TPW1@1239|Firmicutes,24ASV@186801|Clostridia,27MQE@186928|unclassified Lachnospiraceae	186801|Clostridia	P	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,CobT_C,VWA
GNS2_k127_7860568_1	1288.SXYLSMQ121_1379	5.153e-05	56.0	COG0714@1|root,COG0714@2|Bacteria,1TQJA@1239|Firmicutes,4HBG4@91061|Bacilli,4GXI0@90964|Staphylococcaceae	91061|Bacilli	S	ATPase activity	yojN	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
GNS2_k127_8290933_5	926550.CLDAP_37440	8.755e-26	121.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
GNS2_k127_8290933_9	553217.ENHAE0001_1723	0.0002935	50.0	2EDIP@1|root,337EK@2|Bacteria,1N9FX@1224|Proteobacteria,1SHUR@1236|Gammaproteobacteria,3NS5J@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8290933_3	525904.Tter_0993	1.3e-56	211.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
GNS2_k127_8290933_1	1120973.AQXL01000114_gene719	1.522e-127	422.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,277VV@186823|Alicyclobacillaceae	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
GNS2_k127_8290933_7	742742.HMPREF9452_01985	7.712e-15	75.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4CWG7@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
GNS2_k127_8290933_8	321332.CYB_2941	1.5e-10	67.0	COG0594@1|root,COG0594@2|Bacteria,1GP6I@1117|Cyanobacteria,1H2C8@1129|Synechococcus	1117|Cyanobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
GNS2_k127_8290933_6	1288083.AUKR01000010_gene397	4.341e-21	95.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
GNS2_k127_8290933_2	635013.TherJR_1386	1.879e-61	221.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,2655M@186807|Peptococcaceae	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
GNS2_k127_8290933_4	457570.Nther_1101	1.861e-53	204.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
GNS2_k127_8290933_0	292415.Tbd_1500	7.635e-253	790.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KSG5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Inorganic H+ pyrophosphatase	-	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
GNS2_k127_8309706_4	326427.Cagg_1933	5.987e-48	194.0	COG2720@1|root,COG2720@2|Bacteria,2G67R@200795|Chloroflexi,3769S@32061|Chloroflexia	32061|Chloroflexia	V	PFAM VanW family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
GNS2_k127_8309706_1	1118054.CAGW01000046_gene1556	1.156e-90	301.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,4HA8J@91061|Bacilli,26T8H@186822|Paenibacillaceae	91061|Bacilli	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0006355,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051603,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
GNS2_k127_8309706_3	1408422.JHYF01000001_gene3029	7.104e-53	199.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,36DFF@31979|Clostridiaceae	186801|Clostridia	S	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
GNS2_k127_8309706_0	1295642.H839_04704	4.109e-107	379.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,4HB89@91061|Bacilli,1WE4P@129337|Geobacillus	91061|Bacilli	D	Required for chromosome condensation and partitioning	smc	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
GNS2_k127_8309706_10	429009.Adeg_1416	3.413e-12	70.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,42GTF@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
GNS2_k127_8309706_11	1033734.CAET01000018_gene693	1.861e-11	68.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,4HNX0@91061|Bacilli,1ZIW7@1386|Bacillus	91061|Bacilli	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
GNS2_k127_8309706_2	866775.HMPREF9243_1533	2.464e-70	244.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,27DQR@186827|Aerococcaceae	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
GNS2_k127_8309706_6	221288.JH992901_gene4347	1.618e-19	90.0	2DPM9@1|root,332MQ@2|Bacteria,1GAJY@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8309706_8	498761.HM1_3148	5.077e-14	73.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8309706_9	1122619.KB892364_gene1143	3.621e-13	69.0	2EK6X@1|root,33DXA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8309706_13	1121447.JONL01000018_gene3728	3.951e-11	64.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8309706_12	1047013.AQSP01000121_gene2703	2.528e-11	64.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8309706_14	929794.CALV01000065_gene1616	3.635e-06	50.0	2E4EA@1|root,32Z9I@2|Bacteria,1PWSF@1224|Proteobacteria,2V587@28211|Alphaproteobacteria,48UAE@772|Bartonellaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8309706_5	635013.TherJR_2042	9.809e-36	143.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,261SF@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
GNS2_k127_8341452_4	1499967.BAYZ01000095_gene4145	1.976e-94	319.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
GNS2_k127_8341452_6	436114.SYO3AOP1_0698	2.78e-50	186.0	COG3260@1|root,COG3260@2|Bacteria,2G48H@200783|Aquificae	200783|Aquificae	C	PFAM NADH ubiquinone oxidoreductase, 20	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
GNS2_k127_8341452_1	330214.NIDE4265	1.392e-162	535.0	COG0651@1|root,COG0651@2|Bacteria,3J0HR@40117|Nitrospirae	40117|Nitrospirae	CP	Proton-conducting membrane transporter	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
GNS2_k127_8341452_5	330214.NIDE4264	8.263e-77	270.0	COG0650@1|root,COG0650@2|Bacteria,3J0RR@40117|Nitrospirae	40117|Nitrospirae	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
GNS2_k127_8341452_7	436114.SYO3AOP1_0701	4.337e-09	66.0	COG4237@1|root,COG4237@2|Bacteria,2G5AE@200783|Aquificae	200783|Aquificae	C	Hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
GNS2_k127_8341452_3	671143.DAMO_2831	1.739e-99	343.0	COG0651@1|root,COG0651@2|Bacteria,2NS4P@2323|unclassified Bacteria	2|Bacteria	CP	Proton-conducting membrane transporter	hyfF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746	Proton_antipo_M,Proton_antipo_N
GNS2_k127_8341452_2	330214.NIDE4261	2.437e-139	459.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,3J0W2@40117|Nitrospirae	40117|Nitrospirae	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
GNS2_k127_8341452_0	247490.KSU1_D0583	2.124e-189	621.0	COG0474@1|root,COG0474@2|Bacteria,2IXV7@203682|Planctomycetes	203682|Planctomycetes	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,SBP_bac_1
GNS2_k127_8365842_4	1218173.BALCAV_0213780	9.65e-66	237.0	COG3344@1|root,COG3344@2|Bacteria,1UZGP@1239|Firmicutes,4HHRF@91061|Bacilli	91061|Bacilli	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
GNS2_k127_8365842_12	1235793.C809_02685	3.03e-07	57.0	2DMHJ@1|root,32RM0@2|Bacteria,1VBZA@1239|Firmicutes,24P2Z@186801|Clostridia	186801|Clostridia	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
GNS2_k127_8365842_8	1197906.CAJQ02000029_gene3980	8.903e-17	89.0	2A69I@1|root,30V25@2|Bacteria,1R6Y6@1224|Proteobacteria,2U36D@28211|Alphaproteobacteria,3JXYT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8365842_0	515635.Dtur_1796	1.061e-119	401.0	COG0469@1|root,COG0469@2|Bacteria	2|Bacteria	G	pyruvate kinase activity	pyk	GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009986,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0022607,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065	2.7.1.40,2.7.7.4	ko:K00873,ko:K00958	ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050,M00176,M00596	R00200,R00430,R00529,R01138,R01858,R02320,R04929	RC00002,RC00015,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	iECO103_1326.ECO103_1819,iPC815.YPO2393	PEP-utilizers,PK,PK_C
GNS2_k127_8365842_5	500632.CLONEX_03933	1.251e-41	157.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
GNS2_k127_8365842_1	644966.Tmar_0872	2.328e-116	389.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3WCEE@538999|Clostridiales incertae sedis	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
GNS2_k127_8365842_2	1382306.JNIM01000001_gene41	1.003e-102	348.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
GNS2_k127_8365842_9	946235.CAER01000056_gene2924	1.832e-15	80.0	COG0818@1|root,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,4HNKN@91061|Bacilli,23KWD@182709|Oceanobacillus	91061|Bacilli	M	Prokaryotic diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS07900	DAGK_prokar
GNS2_k127_8365842_7	565575.UUR10_0561	4.166e-21	98.0	COG0319@1|root,COG0319@2|Bacteria,3WTYW@544448|Tenericutes	544448|Tenericutes	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
GNS2_k127_8365842_6	945713.IALB_1599	6.246e-24	112.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
GNS2_k127_8365842_10	1123399.AQVE01000027_gene1	3.574e-15	80.0	COG0823@1|root,COG1800@1|root,COG0823@2|Bacteria,COG1800@2|Bacteria,1R2PF@1224|Proteobacteria,1T5UY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8365842_11	1121887.AUDK01000004_gene431	1.69e-11	79.0	COG2911@1|root,COG3210@1|root,COG3533@1|root,COG4625@1|root,COG4733@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3533@2|Bacteria,COG4625@2|Bacteria,COG4733@2|Bacteria,4PPKP@976|Bacteroidetes,1IKQ3@117743|Flavobacteriia,2P0T3@237|Flavobacterium	976|Bacteroidetes	U	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Laminin_G_3
GNS2_k127_8365842_13	502025.Hoch_1452	3.584e-05	58.0	COG2885@1|root,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WMAP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,Phenol_MetA_deg,TSP_3,VWA
GNS2_k127_8365842_15	391625.PPSIR1_25336	0.0006676	55.0	2ANCN@1|root,31DB7@2|Bacteria,1QAGG@1224|Proteobacteria,4352J@68525|delta/epsilon subdivisions,2WZDK@28221|Deltaproteobacteria,2Z1WK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8365842_14	1122182.KB903835_gene4306	0.0003748	53.0	2EEUC@1|root,338MW@2|Bacteria,2IQC9@201174|Actinobacteria,4DF8K@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8365842_3	552811.Dehly_1372	3.045e-102	347.0	COG0124@1|root,COG0124@2|Bacteria,2G64E@200795|Chloroflexi,34CWB@301297|Dehalococcoidia	301297|Dehalococcoidia	J	histidyl-tRNA aminoacylation	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
GNS2_k127_8446809_4	580331.Thit_1419	1.285e-08	59.0	COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,24K3N@186801|Clostridia,42FT9@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM sporulation protein, yteA	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
GNS2_k127_8446809_5	1002367.HMPREF0673_01419	1.44e-06	57.0	COG0597@1|root,COG0597@2|Bacteria,4NEZN@976|Bacteroidetes,2FM3Q@200643|Bacteroidia	976|Bacteroidetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
GNS2_k127_8446809_0	316274.Haur_0685	8.039e-177	567.0	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,37511@32061|Chloroflexia	32061|Chloroflexia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
GNS2_k127_8446809_2	321332.CYB_1473	5.813e-52	193.0	COG0652@1|root,COG0652@2|Bacteria,1G5BD@1117|Cyanobacteria,1H0AB@1129|Synechococcus	1117|Cyanobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	rot	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
GNS2_k127_8446809_3	709986.Deima_2077	1.079e-12	75.0	COG3584@1|root,COG3584@2|Bacteria,1WKHT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	3D domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_8446809_1	316274.Haur_3225	2.92e-116	393.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi,374XI@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
GNS2_k127_851762_0	927658.AJUM01000021_gene968	1.499e-231	731.0	COG0863@1|root,COG3392@1|root,COG0863@2|Bacteria,COG3392@2|Bacteria,4PIKF@976|Bacteroidetes,2G1FK@200643|Bacteroidia,3XM01@558415|Marinilabiliaceae	976|Bacteroidetes	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
GNS2_k127_851762_1	927658.AJUM01000021_gene970	2.505e-57	211.0	28JIT@1|root,2Z9BZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_851762_2	927658.AJUM01000021_gene971	5.378e-36	142.0	2C9HQ@1|root,33SH7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_851762_3	670307.HYPDE_26828	7.964e-23	104.0	COG2856@1|root,COG2856@2|Bacteria,1PCSW@1224|Proteobacteria,2V5N6@28211|Alphaproteobacteria,3N9AM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M78
GNS2_k127_851762_7	1157634.KB912954_gene5831	4.968e-05	51.0	COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,2GMWU@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	GO:0001666,GO:0006082,GO:0006355,GO:0006629,GO:0006631,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016999,GO:0017144,GO:0019219,GO:0019222,GO:0019541,GO:0019679,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0036293,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0046459,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070482,GO:0071704,GO:0075136,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K07110,ko:K21686	-	-	-	-	ko00000,ko03000	-	-	-	DUF2083,HTH_3,HTH_31,Peptidase_M78
GNS2_k127_851762_4	1500281.JQKZ01000021_gene2688	1.536e-21	96.0	2EC1F@1|root,3360K@2|Bacteria,4NX6U@976|Bacteroidetes,1IB6U@117743|Flavobacteriia,3ZTYT@59732|Chryseobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF3892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3892
GNS2_k127_851762_6	1405498.SSIM_07585	1.639e-14	74.0	arCOG12966@1|root,3325K@2|Bacteria,1VNEF@1239|Firmicutes,4I0FX@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_880570_0	56110.Oscil6304_0935	4.213e-06	55.0	COG1413@1|root,COG1413@2|Bacteria,1G7GF@1117|Cyanobacteria	1117|Cyanobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9246056_6	471854.Dfer_1756	0.0001283	53.0	COG1749@1|root,COG3386@1|root,COG1749@2|Bacteria,COG3386@2|Bacteria,4NTUT@976|Bacteroidetes	976|Bacteroidetes	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4082
GNS2_k127_9246056_1	192952.MM_3095	3.361e-48	190.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2NAKT@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
GNS2_k127_9246056_2	309799.DICTH_0471	7.514e-38	157.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	macB_8	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
GNS2_k127_9246056_4	748247.AZKH_1432	6.3e-31	134.0	28VG3@1|root,2ZHIM@2|Bacteria,1RA7E@1224|Proteobacteria,2VQ1V@28216|Betaproteobacteria,2KY3U@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9246056_5	857293.CAAU_0821	3.487e-08	59.0	2DMHJ@1|root,32RM0@2|Bacteria,1VBZA@1239|Firmicutes,24P2Z@186801|Clostridia,36KJR@31979|Clostridiaceae	186801|Clostridia	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
GNS2_k127_9246056_0	857293.CAAU_0822	6.293e-68	246.0	COG3344@1|root,COG3344@2|Bacteria,1UZGP@1239|Firmicutes,24BRP@186801|Clostridia,36FNF@31979|Clostridiaceae	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
GNS2_k127_9246056_3	1321778.HMPREF1982_01510	1.363e-31	138.0	COG0477@1|root,COG2814@2|Bacteria,1UZKT@1239|Firmicutes,25EHZ@186801|Clostridia,26BZA@186813|unclassified Clostridiales	186801|Clostridia	EGP	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
GNS2_k127_9290315_15	388399.SSE37_25423	0.0004444	48.0	COG4409@1|root,COG4409@2|Bacteria,1NK4R@1224|Proteobacteria	1224|Proteobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	SASA
GNS2_k127_9290315_2	400682.PAC_15710341	3.742e-50	184.0	COG4725@1|root,KOG2098@2759|Eukaryota	2759|Eukaryota	KT	primary miRNA methylation	-	-	-	-	-	-	-	-	-	-	-	-	MT-A70
GNS2_k127_9290315_4	742740.HMPREF9474_02378	3.38e-43	167.0	COG5263@1|root,COG5263@2|Bacteria	2|Bacteria	S	dextransucrase activity	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,Lyase_8,Lyase_8_C,Lyase_8_N,Pentapeptide_2,Peptidase_C69,SLH,WG_beta_rep
GNS2_k127_9290315_6	626887.J057_01900	3.151e-18	94.0	2C2XN@1|root,32GT6@2|Bacteria,1REZE@1224|Proteobacteria,1SG9Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ERF superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ERF
GNS2_k127_9290315_8	1171373.PACID_15720	3.662e-14	82.0	COG2887@1|root,COG2887@2|Bacteria,2IBTP@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
GNS2_k127_9290315_17	1347393.HG726022_gene3599	0.000888	49.0	2C7DM@1|root,347VF@2|Bacteria,4P5YV@976|Bacteroidetes,2FZ1P@200643|Bacteroidia	976|Bacteroidetes	S	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9290315_12	525378.HMPREF0793_1859	1.39e-05	52.0	2CDFK@1|root,2Z8BH@2|Bacteria,1V43D@1239|Firmicutes,4HY70@91061|Bacilli	91061|Bacilli	S	DNA N-6-adenine-methyltransferase (Dam)	-	-	-	-	-	-	-	-	-	-	-	-	Dam
GNS2_k127_9290315_5	1038860.AXAP01000007_gene6082	2.796e-28	120.0	COG4725@1|root,COG4725@2|Bacteria,1R553@1224|Proteobacteria,2TRP6@28211|Alphaproteobacteria,3K1HF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KT	MT-A70	-	-	-	-	-	-	-	-	-	-	-	-	MT-A70
GNS2_k127_9290315_3	1461693.ATO10_05931	4.116e-46	175.0	COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2TTZG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase,HTH_3,HTH_31
GNS2_k127_9290315_11	1304878.AUGD01000009_gene6433	3.119e-08	59.0	COG0433@1|root,COG0433@2|Bacteria,1PVGW@1224|Proteobacteria,2U7F3@28211|Alphaproteobacteria,3K00R@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	COG0433 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
GNS2_k127_9290315_7	553217.ENHAE0001_2211	1.237e-16	85.0	2D1MV@1|root,32TAZ@2|Bacteria,1N45A@1224|Proteobacteria,1S954@1236|Gammaproteobacteria,3NQ14@468|Moraxellaceae	1236|Gammaproteobacteria	S	Phage protein (N4 Gp49/phage Sf6 gene 66) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2829,Phage_gp49_66
GNS2_k127_9290315_0	1121428.DESHY_160190___1	1.712e-190	608.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,2611G@186807|Peptococcaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
GNS2_k127_9290315_13	1410658.JHWI01000005_gene925	6.322e-05	51.0	COG0242@1|root,COG0242@2|Bacteria,1V73T@1239|Firmicutes,3VR4V@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins	-	-	-	-	-	-	-	-	-	-	-	-	Pep_deformylase
GNS2_k127_9290315_9	1144932.ATTF01000033_gene4	7.021e-10	64.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,4BQMG@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
GNS2_k127_9290315_1	401526.TcarDRAFT_1283	3.669e-62	233.0	COG1783@1|root,COG3780@1|root,COG5525@1|root,COG1783@2|Bacteria,COG3780@2|Bacteria,COG5525@2|Bacteria	2|Bacteria	S	Phage terminase large subunit (GpA)	-	-	-	ko:K06909	-	-	-	-	ko00000	-	-	-	HTH_3,Terminase_6
GNS2_k127_9290315_10	573370.DMR_04240	1.756e-08	66.0	28NGF@1|root,2ZBII@2|Bacteria,1R9KY@1224|Proteobacteria,435MJ@68525|delta/epsilon subdivisions,2X9BA@28221|Deltaproteobacteria,2M9GG@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9290315_14	999419.HMPREF1077_03353	0.0001634	54.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Glyco_hydro_28,Pectate_lyase_3
GNS2_k127_9290315_16	1423814.HMPREF0549_0129	0.0006473	47.0	COG1388@1|root,COG3757@1|root,COG1388@2|Bacteria,COG3757@2|Bacteria,1V3SH@1239|Firmicutes,4HNR1@91061|Bacilli,3F6ZF@33958|Lactobacillaceae	91061|Bacilli	M	hydrolase, family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25,LysM,SH3_5
GNS2_k127_9409011_0	880073.Calab_0536	2.208e-73	257.0	COG1209@1|root,COG1209@2|Bacteria,2NNTJ@2323|unclassified Bacteria	2|Bacteria	M	Nucleotidyl transferase	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
GNS2_k127_9409011_1	304371.MCP_1928	2.202e-40	160.0	COG1216@1|root,arCOG01383@2157|Archaea,2XX17@28890|Euryarchaeota,2NBGD@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyltransferase like family	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
GNS2_k127_9575020_0	1469607.KK073768_gene3614	2.942e-71	248.0	COG3293@1|root,COG3293@2|Bacteria,1G0BW@1117|Cyanobacteria,1HNSC@1161|Nostocales	1117|Cyanobacteria	L	transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
GNS2_k127_9709_5	215803.DB30_5233	2.346e-51	211.0	COG4733@1|root,COG4733@2|Bacteria,1QX65@1224|Proteobacteria,43BYR@68525|delta/epsilon subdivisions,2X79M@28221|Deltaproteobacteria,2YZ8E@29|Myxococcales	28221|Deltaproteobacteria	G	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
GNS2_k127_9709_3	1408224.SAMCCGM7_c3749	8.252e-73	282.0	COG2730@1|root,COG2730@2|Bacteria,1R544@1224|Proteobacteria,2U1MT@28211|Alphaproteobacteria,4BD0S@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Putative collagen-binding domain of a collagenase	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2,DUF4038
GNS2_k127_9709_7	1274374.CBLK010000009_gene4394	9.479e-32	146.0	COG3397@1|root,COG3469@1|root,COG3397@2|Bacteria,COG3469@2|Bacteria,1TT45@1239|Firmicutes,4HEJN@91061|Bacilli,26TIE@186822|Paenibacillaceae	91061|Bacilli	G	PFAM chitin-binding domain 3 protein	-	-	-	-	-	-	-	-	-	-	-	-	LPMO_10,fn3
GNS2_k127_9709_0	118173.KB235914_gene3829	2.27e-95	355.0	2DBP2@1|root,2ZA71@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9709_10	189426.PODO_25955	6.072e-17	97.0	COG0366@1|root,COG2819@1|root,COG4733@1|root,COG0366@2|Bacteria,COG2819@2|Bacteria,COG4733@2|Bacteria,1TSVI@1239|Firmicutes,4HCV2@91061|Bacilli,26R7N@186822|Paenibacillaceae	91061|Bacilli	G	belongs to the glycosyl hydrolase 13 family	nplT	GO:0005575,GO:0005576	3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54	ko:K01176,ko:K01208	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_N,CBM_20,CBM_25,Glyco_hydro_14,TIG,fn3
GNS2_k127_9709_8	1400524.KL370779_gene1147	7.812e-21	94.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,4BQ5Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
GNS2_k127_9709_11	1219031.BBJR01000038_gene3131	9.913e-09	61.0	COG1622@1|root,COG2132@1|root,COG1622@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2VK95@28216|Betaproteobacteria,4AGYB@80864|Comamonadaceae	28216|Betaproteobacteria	CQ	Copper binding proteins, plastocyanin/azurin family	nirK	-	1.3.3.5,1.7.2.1	ko:K00368,ko:K08100	ko00860,ko00910,ko01110,ko01120,map00860,map00910,map01110,map01120	M00529	R00783,R00785,R02394	RC00086,RC01983	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cytochrome_CBB3
GNS2_k127_9709_1	1321778.HMPREF1982_01904	1.764e-86	293.0	COG1814@1|root,COG1814@2|Bacteria,1V4D2@1239|Firmicutes	1239|Firmicutes	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
GNS2_k127_9709_2	1111479.AXAR01000001_gene152	8.822e-76	264.0	COG1054@1|root,COG1054@2|Bacteria,1TRG7@1239|Firmicutes,4HA0J@91061|Bacilli,279FB@186823|Alicyclobacillaceae	91061|Bacilli	S	Rhodanase C-terminal	ybfQ	-	-	ko:K07146	-	-	-	-	ko00000	-	-	-	Rhodanese,Rhodanese_C
GNS2_k127_9709_9	722419.PH505_ac01120	6.414e-18	87.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,2PZMW@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0025,iJN746.PP_0602	FAD_syn,Flavokinase
GNS2_k127_9709_6	1545701.LACWKB10_0764	5.785e-46	172.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4HC7B@91061|Bacilli,3F6M0@33958|Lactobacillaceae	91061|Bacilli	H	Riboflavin synthase	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08950,iYO844.BSU23270	Lum_binding
GNS2_k127_9709_4	1122602.ATXP01000004_gene1865	2.492e-71	248.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,1W7E7@1268|Micrococcaceae	201174|Actinobacteria	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
GNS2_k127_974549_15	1300143.CCAV010000001_gene1179	1.297e-11	77.0	COG5295@1|root,COG5295@2|Bacteria,4NTMP@976|Bacteroidetes,1I4NQ@117743|Flavobacteriia,3ZPHH@59732|Chryseobacterium	976|Bacteroidetes	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Fib_succ_major
GNS2_k127_974549_18	391625.PPSIR1_40859	6.338e-07	63.0	2DSD6@1|root,33FM0@2|Bacteria,1PBXM@1224|Proteobacteria,43862@68525|delta/epsilon subdivisions,2X3FW@28221|Deltaproteobacteria,2YVX7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_974549_2	521095.Apar_0186	4.716e-116	383.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4CUCP@84998|Coriobacteriia	84998|Coriobacteriia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
GNS2_k127_974549_7	1151117.AJLF01000001_gene1316	1.978e-29	132.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
GNS2_k127_974549_11	221288.JH992901_gene1779	4.394e-19	99.0	COG4972@1|root,COG4972@2|Bacteria,1G0A3@1117|Cyanobacteria,1JGT6@1189|Stigonemataceae	1117|Cyanobacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
GNS2_k127_974549_4	269799.Gmet_1395	6.189e-65	235.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,43TBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
GNS2_k127_974549_1	648996.Theam_0511	5.555e-148	487.0	COG2804@1|root,COG2804@2|Bacteria,2G3UR@200783|Aquificae	200783|Aquificae	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
GNS2_k127_974549_19	246194.CHY_0035	2.03e-06	56.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,42GZP@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
GNS2_k127_974549_6	1201290.M902_0516	6.242e-38	147.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2MT2P@213481|Bdellovibrionales,2WNAN@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
GNS2_k127_974549_13	546271.Selsp_2086	2.911e-13	72.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,4H53V@909932|Negativicutes	909932|Negativicutes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
GNS2_k127_974549_3	570952.ATVH01000016_gene2539	6.959e-66	238.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,2TRD4@28211|Alphaproteobacteria,2JPQD@204441|Rhodospirillales	204441|Rhodospirillales	J	lysyl-tRNA synthetase	poxA	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
GNS2_k127_974549_5	555079.Toce_1324	3.424e-48	179.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,42FJ9@68295|Thermoanaerobacterales	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
GNS2_k127_974549_0	1499967.BAYZ01000055_gene4861	2.187e-182	594.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	dedA	-	3.6.1.27	ko:K03975,ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
GNS2_k127_974549_9	1449355.JQNR01000005_gene3482	2.141e-25	113.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
GNS2_k127_974549_10	1151126.AQYI01000004_gene935	3.961e-24	118.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria,4FPHZ@85023|Microbacteriaceae	201174|Actinobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Collagen,DUF3494
GNS2_k127_974549_12	388413.ALPR1_00005	2.751e-13	83.0	COG2931@1|root,COG3209@1|root,COG2931@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF4347,PKD,SdrD_B
GNS2_k127_974549_8	926550.CLDAP_04950	4.83e-27	119.0	COG3764@1|root,COG3764@2|Bacteria,2G77W@200795|Chloroflexi	200795|Chloroflexi	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
GNS2_k127_974549_16	1366050.N234_09725	2.324e-10	70.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,2W570@28216|Betaproteobacteria,1K7M5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
GNS2_k127_974549_17	1254432.SCE1572_04680	4.826e-07	62.0	COG1032@1|root,COG1032@2|Bacteria,1R9RK@1224|Proteobacteria,43AIF@68525|delta/epsilon subdivisions,2X5YQ@28221|Deltaproteobacteria,2YUK6@29|Myxococcales	28221|Deltaproteobacteria	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
GNS2_k127_974549_14	1366050.N234_09725	3.924e-12	76.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,2W570@28216|Betaproteobacteria,1K7M5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
GNS2_k127_9769741_3	1157490.EL26_18935	3.323e-21	100.0	2DBDP@1|root,32TXA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9769741_4	436308.Nmar_0198	2.998e-12	73.0	arCOG06293@1|root,arCOG06293@2157|Archaea,41T3S@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9769741_0	1123009.AUID01000013_gene1715	1.44e-193	634.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,267MY@186813|unclassified Clostridiales	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
GNS2_k127_9769741_1	926550.CLDAP_04380	1.521e-46	184.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2G6Q7@200795|Chloroflexi	200795|Chloroflexi	M	Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23,SH3_3
GNS2_k127_9769741_2	309801.trd_0705	4.813e-38	147.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi,27XGS@189775|Thermomicrobia	189775|Thermomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
GNS2_k127_9817456_15	526227.Mesil_1223	9.669e-06	59.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF11,SdrD_B,SprB
GNS2_k127_9817456_4	1205680.CAKO01000006_gene3232	1.186e-34	149.0	2DTAA@1|root,33JEH@2|Bacteria,1NFFI@1224|Proteobacteria,2UFJK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9817456_17	1408813.AYMG01000010_gene645	0.0005555	44.0	2EIK5@1|root,33CBF@2|Bacteria,4NV2P@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9817456_1	1149133.ppKF707_0745	1.22e-74	263.0	COG0863@1|root,COG0863@2|Bacteria,1QXR3@1224|Proteobacteria,1T3H2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
GNS2_k127_9817456_3	331113.SNE_B23940	2.567e-53	197.0	COG3723@1|root,COG3723@2|Bacteria	2|Bacteria	L	DNA synthesis involved in double-strand break repair via homologous recombination	bet	-	-	ko:K07455	-	-	-	-	ko00000,ko03400	-	-	-	RecT
GNS2_k127_9817456_14	1500890.JQNL01000001_gene3289	9.213e-06	52.0	2BPXD@1|root,32IR2@2|Bacteria,1QGM2@1224|Proteobacteria,1TE1U@1236|Gammaproteobacteria,1XBBI@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9817456_12	388467.A19Y_2471	1.22e-07	59.0	2EJ6P@1|root,33CXW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9817456_5	395493.BegalDRAFT_0434	3.049e-33	138.0	COG2129@1|root,COG2129@2|Bacteria,1RFU9@1224|Proteobacteria,1S4S2@1236|Gammaproteobacteria,463TS@72273|Thiotrichales	72273|Thiotrichales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
GNS2_k127_9817456_11	1121342.AUCO01000007_gene734	2.709e-09	66.0	COG2931@1|root,COG2931@2|Bacteria,1TSGB@1239|Firmicutes,247TS@186801|Clostridia,36F14@31979|Clostridiaceae	186801|Clostridia	Q	PFAM Collagen triple helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	C1q,Collagen
GNS2_k127_9817456_0	1329516.JPST01000014_gene657	7.846e-95	325.0	COG1783@1|root,COG1783@2|Bacteria,1TT2C@1239|Firmicutes,4H9S2@91061|Bacilli	91061|Bacilli	S	Phage terminase, large subunit	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
GNS2_k127_9817456_2	439235.Dalk_3969	2.802e-74	274.0	COG3170@1|root,COG3170@2|Bacteria,1N4R0@1224|Proteobacteria,42QKG@68525|delta/epsilon subdivisions,2WMF1@28221|Deltaproteobacteria,2MP7B@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9817456_9	439235.Dalk_3972	8.396e-17	91.0	28W6R@1|root,2ZI7D@2|Bacteria,1N49N@1224|Proteobacteria,431A7@68525|delta/epsilon subdivisions,2WWPT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNS2_k127_9817456_10	395495.Lcho_2257	8.443e-13	80.0	COG4961@1|root,COG4961@2|Bacteria	2|Bacteria	U	PFAM TadE family protein	tadG1	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	TadE
GNS2_k127_993166_1	179408.Osc7112_0326	4.571e-05	52.0	COG1404@1|root,COG3409@1|root,COG1404@2|Bacteria,COG3409@2|Bacteria,1G2HU@1117|Cyanobacteria,1H9MN@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,Peptidase_S8
GNS2_k127_993166_0	404589.Anae109_0821	1.293e-40	160.0	COG0682@1|root,COG0682@2|Bacteria,1Q2R4@1224|Proteobacteria,438CQ@68525|delta/epsilon subdivisions,2WP0G@28221|Deltaproteobacteria,2YWK4@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
## 874 queries scanned
## Total time (seconds): 173.08590245246887
## Rate: 5.05 q/s