## Fri Nov 15 21:20:03 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin6/GZD_1_bin.21.fa -m mmseqs --itype genome -o GZD_1_bin.21 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/GZD_1_bin.21 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs GZD1_k127_1024587_0 1214101.BN159_8358 1.314e-14 84.0 COG1874@1|root,COG2931@1|root,COG4409@1|root,COG1874@2|Bacteria,COG2931@2|Bacteria,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - BNR,BNR_2 GZD1_k127_1051893_0 1123508.JH636439_gene1853 5.603e-145 482.0 COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg GZD1_k127_1051893_1 716928.AJQT01000101_gene310 5.911e-08 65.0 COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2TW52@28211|Alphaproteobacteria,4BM3R@82115|Rhizobiaceae 28211|Alphaproteobacteria K Cupin - - - - - - - - - - - - Cupin_6,HTH_18 GZD1_k127_1057870_6 1122169.AREN01000056_gene2019 2.543e-06 54.0 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1JECV@118969|Legionellales 118969|Legionellales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE GZD1_k127_1057870_0 1211114.ALIP01000160_gene1610 1.878e-226 704.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1X48A@135614|Xanthomonadales 135614|Xanthomonadales J GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 GZD1_k127_1057870_5 1033734.CAET01000079_gene3557 2.705e-09 58.0 29S70@1|root,30DBH@2|Bacteria,1UB40@1239|Firmicutes,4IMGK@91061|Bacilli,1ZK45@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - GZD1_k127_1057870_3 765910.MARPU_09040 3.506e-82 282.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1WW93@135613|Chromatiales 135613|Chromatiales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 GZD1_k127_1057870_1 84531.JMTZ01000081_gene1307 9.368e-146 467.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP GZD1_k127_1057870_2 522373.Smlt3277 2.887e-123 406.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X47D@135614|Xanthomonadales 135614|Xanthomonadales E Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine metX GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 GZD1_k127_1057870_4 323261.Noc_0214 7.201e-12 69.0 292KW@1|root,2ZQ4T@2|Bacteria,1PAY1@1224|Proteobacteria,1SVTB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ GZD1_k127_1138523_0 1379270.AUXF01000004_gene3046 4.192e-304 942.0 COG0086@1|root,COG0303@1|root,COG0086@2|Bacteria,COG0303@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 GZD1_k127_1159331_1 481448.Minf_0180 3.387e-37 143.0 COG0448@1|root,COG0448@2|Bacteria,46SG2@74201|Verrucomicrobia,37FVE@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia G Nucleotidyl transferase glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase GZD1_k127_1159331_0 392499.Swit_1082 1.148e-111 374.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K0U5@204457|Sphingomonadales 28211|Alphaproteobacteria E peptidase S10 serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 GZD1_k127_116440_4 1120949.KB903299_gene5889 1.973e-96 327.0 COG0604@1|root,COG0604@2|Bacteria,2GK40@201174|Actinobacteria,4DH8E@85008|Micromonosporales 201174|Actinobacteria C Zinc-binding dehydrogenase fadB5 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 GZD1_k127_116440_1 1283300.ATXB01000001_gene1705 5.531e-176 569.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1SZW9@1236|Gammaproteobacteria,1XFPE@135618|Methylococcales 135618|Methylococcales L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP GZD1_k127_116440_7 215803.DB30_0176 2.576e-68 246.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42UDG@68525|delta/epsilon subdivisions,2WQAB@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran GZD1_k127_116440_8 215803.DB30_0177 1.288e-55 204.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42U9W@68525|delta/epsilon subdivisions 1224|Proteobacteria P ABC 3 transport family - - - ko:K09819,ko:K11606,ko:K11708,ko:K11709 ko02010,map02010 M00243,M00317,M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.7,3.A.1.15.9 - - ABC-3,Fe_dep_repr_C GZD1_k127_116440_2 1173024.KI912151_gene2146 1.088e-174 562.0 COG2312@1|root,COG2312@2|Bacteria,1GA2Z@1117|Cyanobacteria,1JKPG@1189|Stigonemataceae 1117|Cyanobacteria S Erythromycin esterase - - - - - - - - - - - - Erythro_esteras GZD1_k127_116440_6 1128421.JAGA01000003_gene2827 6.467e-69 252.0 COG1926@1|root,COG1926@2|Bacteria,2NQVQ@2323|unclassified Bacteria 2|Bacteria S Phosphoribosyl transferase domain minD GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07100 - - - - ko00000 - - - Erythro_esteras,Pribosyltran GZD1_k127_116440_5 2002.JOEQ01000013_gene5463 3.247e-69 244.0 COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4EGKY@85012|Streptosporangiales 201174|Actinobacteria S Phosphoribosyl transferase domain - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07100 - - - - ko00000 - - - DLH,Pribosyltran GZD1_k127_116440_3 861299.J421_3743 4.037e-162 526.0 COG2805@1|root,COG2805@2|Bacteria,1ZSTM@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE GZD1_k127_116440_0 1340493.JNIF01000004_gene652 5.426e-242 763.0 COG2274@1|root,COG2274@2|Bacteria 2|Bacteria V protein secretion by the type I secretion system - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran GZD1_k127_116440_10 522772.Dacet_0235 0.0005123 43.0 COG3216@1|root,COG3216@2|Bacteria 2|Bacteria M Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 GZD1_k127_1208993_11 861299.J421_4449 2.667e-36 152.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_1208993_7 1267533.KB906737_gene1752 2.758e-55 207.0 COG1131@1|root,COG1131@2|Bacteria,3Y50U@57723|Acidobacteria,2JM9C@204432|Acidobacteriia 204432|Acidobacteriia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_1208993_15 315750.BPUM_2677 4.248e-18 88.0 COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,4HNIT@91061|Bacilli,1ZGQV@1386|Bacillus 91061|Bacilli K GntR family transcriptional regulator ytrA - - ko:K07979 - - - - ko00000,ko03000 - - - GntR GZD1_k127_1208993_5 1389489.O159_24000 3.43e-96 331.0 COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4FMCN@85023|Microbacteriaceae 201174|Actinobacteria C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase GZD1_k127_1208993_6 42256.RradSPS_2166 5.903e-80 292.0 COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4CQ48@84995|Rubrobacteria 84995|Rubrobacteria S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase GZD1_k127_1208993_8 1278073.MYSTI_06620 5.756e-52 186.0 COG0251@1|root,COG0251@2|Bacteria,1RES6@1224|Proteobacteria,435VN@68525|delta/epsilon subdivisions,2X0B9@28221|Deltaproteobacteria,2Z1FV@29|Myxococcales 28221|Deltaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP GZD1_k127_1208993_17 649743.HMPREF0972_01776 1.225e-13 79.0 COG2314@1|root,COG2314@2|Bacteria,2GU27@201174|Actinobacteria 201174|Actinobacteria M TM2 domain - - - - - - - - - - - - DUF2510,TM2 GZD1_k127_1208993_4 395961.Cyan7425_2243 2.241e-110 369.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,3KGN0@43988|Cyanothece 1117|Cyanobacteria C PFAM alanine dehydrogenase PNT domain protein pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N GZD1_k127_1208993_14 1156937.MFUM_390011 1.135e-22 106.0 COG3288@1|root,COG3288@2|Bacteria,46T7S@74201|Verrucomicrobia,37H24@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C 4TM region of pyridine nucleotide transhydrogenase, mitoch - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM GZD1_k127_1208993_1 1382359.JIAL01000001_gene96 2.208e-166 540.0 COG1282@1|root,COG1282@2|Bacteria,3Y42H@57723|Acidobacteria,2JM1F@204432|Acidobacteriia 204432|Acidobacteriia C NAD(P) transhydrogenase beta subunit - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB GZD1_k127_1208993_0 861299.J421_2179 1.878e-245 772.0 COG0308@1|root,COG0308@2|Bacteria,1ZUT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 GZD1_k127_1208993_2 469383.Cwoe_5384 4.268e-159 523.0 COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria 201174|Actinobacteria E Oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3 GZD1_k127_1208993_18 101028.EKJ76880 1.738e-05 55.0 2CDKK@1|root,2S3EP@2759|Eukaryota,3A56C@33154|Opisthokonta,3P4UG@4751|Fungi,3QXSR@4890|Ascomycota,21BMU@147550|Sordariomycetes,3TRPS@5125|Hypocreales,1FY8C@110618|Nectriaceae 4751|Fungi S Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase GZD1_k127_1208993_9 208444.JNYY01000024_gene457 1.883e-39 152.0 COG1764@1|root,COG1764@2|Bacteria,2IQ3I@201174|Actinobacteria,4EAN3@85010|Pseudonocardiales 201174|Actinobacteria O OsmC-like protein - - - ko:K04063 - - - - ko00000 - - - OsmC GZD1_k127_1208993_3 290397.Adeh_3989 4.187e-128 422.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,42RD4@68525|delta/epsilon subdivisions,2WN11@28221|Deltaproteobacteria,2YU83@29|Myxococcales 28221|Deltaproteobacteria G Organic Anion Transporter Polypeptide (OATP) family - - - - - - - - - - - - MFS_1 GZD1_k127_1208993_13 1278073.MYSTI_00493 9.078e-25 107.0 COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,42V9P@68525|delta/epsilon subdivisions,2X5QW@28221|Deltaproteobacteria,2Z1ZE@29|Myxococcales 28221|Deltaproteobacteria L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG GZD1_k127_1208993_10 861299.J421_4349 2.347e-36 149.0 COG3346@1|root,COG3346@2|Bacteria,1ZTTS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SURF1 family - - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 GZD1_k127_1208993_12 1267535.KB906767_gene2749 1.378e-33 138.0 COG3620@1|root,COG3620@2|Bacteria,3Y6X6@57723|Acidobacteria 57723|Acidobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 GZD1_k127_1208993_16 379066.GAU_2739 1.272e-16 79.0 COG1278@1|root,COG1278@2|Bacteria,1ZV0Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Ribonuclease B OB domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD GZD1_k127_121448_2 1379270.AUXF01000005_gene667 9.564e-09 56.0 COG2204@1|root,COG2204@2|Bacteria,1ZTMH@142182|Gemmatimonadetes 142182|Gemmatimonadetes T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg GZD1_k127_121448_1 394221.Mmar10_0659 3.64e-11 72.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2U59Y@28211|Alphaproteobacteria,43YBI@69657|Hyphomonadaceae 28211|Alphaproteobacteria NT Two component signalling adaptor domain cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW GZD1_k127_121448_0 1379270.AUXF01000005_gene665 6.257e-84 290.0 COG0564@1|root,COG0564@2|Bacteria,1ZSXN@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 GZD1_k127_123107_11 861299.J421_3217 1.643e-16 81.0 COG0542@1|root,COG0542@2|Bacteria,1ZTBV@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Clp amino terminal domain, pathogenicity island component - - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR GZD1_k127_123107_2 1379270.AUXF01000006_gene305 9.822e-133 440.0 COG3869@1|root,COG3869@2|Bacteria,1ZT9I@142182|Gemmatimonadetes 142182|Gemmatimonadetes F ATP:guanido phosphotransferase, C-terminal catalytic domain - - 2.7.14.1 ko:K19405 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - ATP-gua_Ptrans GZD1_k127_123107_8 1379270.AUXF01000006_gene306 1.759e-44 176.0 COG3880@1|root,COG3880@2|Bacteria,1ZTPQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S UvrB/uvrC motif - - - ko:K19411 - - - - ko00000 - - - UVR GZD1_k127_123107_6 861299.J421_3214 1.019e-78 272.0 COG1136@1|root,COG1136@2|Bacteria,1ZSNF@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran GZD1_k127_123107_3 861299.J421_3213 6.051e-116 389.0 COG4591@1|root,COG4591@2|Bacteria,1ZT1N@142182|Gemmatimonadetes 142182|Gemmatimonadetes M MacB-like periplasmic core domain - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD GZD1_k127_123107_0 518766.Rmar_0302 1.786e-149 488.0 COG1190@1|root,COG1190@2|Bacteria,4NDZN@976|Bacteroidetes,1FISX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF4332,tRNA-synt_2,tRNA_anti-codon GZD1_k127_123107_1 861299.J421_3211 9.071e-134 435.0 COG1186@1|root,COG1186@2|Bacteria,1ZTE4@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 GZD1_k127_123107_9 861299.J421_3210 1.639e-37 153.0 2F3JX@1|root,33WDB@2|Bacteria,1ZTZI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - zinc_ribbon_4 GZD1_k127_123107_4 1379270.AUXF01000006_gene312 1.453e-96 326.0 COG2199@1|root,COG2199@2|Bacteria,1ZT1F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF GZD1_k127_123107_7 379066.GAU_1575 3.048e-45 184.0 2BXP0@1|root,34268@2|Bacteria,1ZTVK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_123107_13 518766.Rmar_2396 7.424e-06 58.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - - GZD1_k127_123107_12 861299.J421_3206 1.891e-15 80.0 COG2835@1|root,COG2835@2|Bacteria,1ZU7Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Trm112p-like protein - - - ko:K09791 - - - - ko00000 - - - Trm112p GZD1_k127_123107_5 861299.J421_3205 1.69e-86 298.0 COG1159@1|root,COG1159@2|Bacteria,1ZUSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 GZD1_k127_123107_10 1121875.KB907563_gene4 6.024e-31 123.0 2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia 976|Bacteroidetes S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - GZD1_k127_128154_0 379066.GAU_1936 7.267e-186 588.0 COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N GZD1_k127_128154_1 861299.J421_3543 8.752e-106 357.0 COG1228@1|root,COG1228@2|Bacteria,1ZSNQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Amidohydrolase family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 GZD1_k127_128154_2 861299.J421_3542 1.043e-23 105.0 COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 GZD1_k127_1399019_0 861299.J421_2757 1.73e-163 533.0 COG0215@1|root,COG0215@2|Bacteria,1ZT77@142182|Gemmatimonadetes 142182|Gemmatimonadetes J DALR_2 cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e GZD1_k127_1399019_2 671143.DAMO_2882 9.584e-54 200.0 COG0668@1|root,COG0668@2|Bacteria,2NPY4@2323|unclassified Bacteria 2|Bacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel GZD1_k127_1399019_4 224911.27348565 3.846e-24 118.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSI2@28211|Alphaproteobacteria,3JQY0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system nosF - - ko:K01990,ko:K19340 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC_tran GZD1_k127_1399019_1 1379270.AUXF01000004_gene3060 3.21e-122 410.0 COG3367@1|root,COG3367@2|Bacteria,1ZUM9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N GZD1_k127_1399019_3 861299.J421_2755 5.05e-53 197.0 COG0628@1|root,COG0628@2|Bacteria 2|Bacteria D permease - - - - - - - - - - - - AI-2E_transport GZD1_k127_1526161_1 1379270.AUXF01000004_gene3318 8.994e-65 236.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1ZSP0@142182|Gemmatimonadetes 142182|Gemmatimonadetes DM Chain length determinant protein - - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - GNVR GZD1_k127_1526161_0 379066.GAU_0578 2.124e-180 580.0 COG2204@1|root,COG2204@2|Bacteria,1ZSZ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_1526161_2 861299.J421_2500 2.143e-06 59.0 COG0642@1|root,COG0642@2|Bacteria,1ZTZE@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA GZD1_k127_1532909_2 861299.J421_3417 8.945e-116 395.0 COG0439@1|root,COG0439@2|Bacteria,1ZTBD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 GZD1_k127_1532909_0 861299.J421_3418 1.606e-250 780.0 COG4799@1|root,COG4799@2|Bacteria,1ZTGE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans GZD1_k127_1532909_1 379066.GAU_1789 1.397e-162 515.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1ZSKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 GZD1_k127_1560151_11 379066.GAU_0655 8.949e-53 193.0 COG2094@1|root,COG2094@2|Bacteria,1ZTNT@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Methylpurine-DNA glycosylase (MPG) - - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco GZD1_k127_1560151_1 379066.GAU_0656 8.779e-177 575.0 COG0156@1|root,COG0156@2|Bacteria,1ZST6@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Beta-eliminating lyase - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 GZD1_k127_1560151_3 1379270.AUXF01000004_gene3224 5.038e-133 432.0 COG1063@1|root,COG1063@2|Bacteria,1ZSWB@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Zinc-binding dehydrogenase - - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N GZD1_k127_1560151_17 861299.J421_2615 2.513e-28 129.0 COG4123@1|root,COG4123@2|Bacteria,1ZTJ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - - - - - - - - - - - GZD1_k127_1560151_12 309801.trd_A0302 4.154e-50 191.0 COG0053@1|root,COG0053@2|Bacteria,2G5MK@200795|Chloroflexi,27XQA@189775|Thermomicrobia 189775|Thermomicrobia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer GZD1_k127_1560151_18 867903.ThesuDRAFT_01152 9.099e-21 98.0 COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,24NEC@186801|Clostridia,3WDRA@538999|Clostridiales incertae sedis 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 GZD1_k127_1560151_13 867903.ThesuDRAFT_01151 2.042e-49 183.0 COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,24HIG@186801|Clostridia,3WDJQ@538999|Clostridiales incertae sedis 186801|Clostridia S SdpI/YhfL protein family sdpI - - - - - - - - - - - DUF1648,SdpI GZD1_k127_1560151_4 861299.J421_2617 3.797e-128 426.0 COG1092@1|root,COG1092@2|Bacteria,1ZT8Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM GZD1_k127_1560151_16 1128421.JAGA01000003_gene3433 6.287e-30 131.0 COG4401@1|root,COG4401@2|Bacteria 2|Bacteria E Chorismate mutase type I aroH GO:0003674,GO:0003824,GO:0004106,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046417,GO:0071704 2.7.4.25,5.4.99.5 ko:K00945,ko:K06208 ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230 M00024,M00025,M00052 R00158,R00512,R01665,R01715 RC00002,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_1 GZD1_k127_1560151_14 644968.DFW101_3639 4.859e-33 140.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42NTP@68525|delta/epsilon subdivisions,2WURY@28221|Deltaproteobacteria,2MG3H@213115|Desulfovibrionales 28221|Deltaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI GZD1_k127_1560151_8 861299.J421_2620 1.761e-69 252.0 COG1559@1|root,COG1559@2|Bacteria,1ZTA7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG GZD1_k127_1560151_15 861299.J421_2621 4.547e-30 125.0 COG0816@1|root,COG0816@2|Bacteria,1ZTWG@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX GZD1_k127_1560151_0 861299.J421_2622 1.536e-217 682.0 COG1158@1|root,COG1158@2|Bacteria,1ZSXH@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind GZD1_k127_1560151_23 635013.TherJR_2689 7.154e-10 66.0 COG0399@1|root,COG0399@2|Bacteria,1VGIE@1239|Firmicutes,24PJD@186801|Clostridia,265WY@186807|Peptococcaceae 186801|Clostridia M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP GZD1_k127_1560151_6 861299.J421_2456 2.006e-94 332.0 COG1300@1|root,COG1714@1|root,COG1300@2|Bacteria,COG1714@2|Bacteria 2|Bacteria S RDD family - - - ko:K06384 - - - - ko00000 - - - RDD,SpoIIM GZD1_k127_1560151_22 1246445.ANAY01000006_gene3891 2.105e-11 74.0 COG4223@1|root,COG4223@2|Bacteria,2I390@201174|Actinobacteria,4EJ5Z@85012|Streptosporangiales 201174|Actinobacteria DZ transferase activity, transferring acyl groups other than amino-acyl groups - - - - - - - - - - - - GPDPase_memb GZD1_k127_1560151_25 1112216.JH594425_gene2132 0.0003933 50.0 2C58E@1|root,32V5I@2|Bacteria,1N13T@1224|Proteobacteria,2UBSB@28211|Alphaproteobacteria,2K675@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - DUF4129 GZD1_k127_1560151_24 383372.Rcas_2511 4.356e-08 65.0 2E0NP@1|root,32W7Q@2|Bacteria,2G9D8@200795|Chloroflexi,375QK@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF4350) - - - - - - - - - - - - DUF4350 GZD1_k127_1560151_5 33898.JRHJ01000004_gene2182 1.309e-96 341.0 COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria 201174|Actinobacteria S associated with various cellular activities moxR2 - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 GZD1_k127_1560151_7 861299.J421_2457 1.941e-75 271.0 COG1721@1|root,COG1721@2|Bacteria 2|Bacteria E protein (some members contain a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - DUF11,DUF58 GZD1_k127_1560151_9 861299.J421_4449 2.3e-69 263.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_1560151_2 234267.Acid_0065 1.022e-155 516.0 COG1680@1|root,COG1680@2|Bacteria,3Y4J4@57723|Acidobacteria 57723|Acidobacteria V Domain of unknown function (DUF3471) - - - - - - - - - - - - Beta-lactamase,DUF3471 GZD1_k127_1560151_10 641524.ADICYQ_2957 2.852e-54 198.0 COG0702@1|root,COG0702@2|Bacteria,4NZXB@976|Bacteroidetes 976|Bacteroidetes GM NAD(P)H-binding - - - - - - - - - - - - NAD_binding_10 GZD1_k127_1560151_20 357808.RoseRS_3483 8.042e-13 78.0 2DN0I@1|root,32UR2@2|Bacteria,2G8Y2@200795|Chloroflexi,375Q5@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 GZD1_k127_1560151_19 1249627.D779_3808 2.026e-18 87.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1X1T9@135613|Chromatiales 135613|Chromatiales L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase GZD1_k127_1581512_6 1379270.AUXF01000006_gene55 1.601e-50 196.0 COG0697@1|root,COG0697@2|Bacteria,1ZUKF@142182|Gemmatimonadetes 142182|Gemmatimonadetes EG EamA-like transporter family - - - - - - - - - - - - EamA GZD1_k127_1581512_4 215803.DB30_4629 7.846e-97 327.0 COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,42RKM@68525|delta/epsilon subdivisions,2WNVJ@28221|Deltaproteobacteria,2YX74@29|Myxococcales 28221|Deltaproteobacteria E L-asparaginase II - - - - - - - - - - - - Asparaginase_II GZD1_k127_1581512_8 861299.J421_3473 9.406e-31 132.0 COG0599@1|root,COG0599@2|Bacteria,1ZTPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD GZD1_k127_1581512_7 1210884.HG799473_gene15014 9.863e-33 131.0 2CCSR@1|root,32RWC@2|Bacteria,2J1M5@203682|Planctomycetes 203682|Planctomycetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP GZD1_k127_1581512_0 861299.J421_3472 3.132e-135 437.0 COG0536@1|root,COG0536@2|Bacteria,1ZSVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 GZD1_k127_1581512_5 926550.CLDAP_39650 3.55e-62 236.0 COG0758@1|root,COG0758@2|Bacteria,2G5UA@200795|Chloroflexi 200795|Chloroflexi L TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A GZD1_k127_1581512_1 861299.J421_3470 5.846e-121 400.0 COG0635@1|root,COG0635@2|Bacteria,1ZSSU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Radical_SAM GZD1_k127_1581512_2 379066.GAU_1899 5.904e-118 388.0 COG1420@1|root,COG1420@2|Bacteria,1ZTER@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA GZD1_k127_1581512_3 903814.ELI_3542 4.27e-103 348.0 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,25UX4@186806|Eubacteriaceae 186801|Clostridia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG GZD1_k127_1581512_9 861299.J421_3465 4.461e-24 109.0 COG0537@1|root,COG0537@2|Bacteria,1ZU0K@142182|Gemmatimonadetes 142182|Gemmatimonadetes FG HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT GZD1_k127_1592038_35 456442.Mboo_0031 9.833e-19 93.0 COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia 224756|Methanomicrobia M Large-conductance mechanosensitive channel, MscL - - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL GZD1_k127_1592038_4 469383.Cwoe_4029 1.512e-127 413.0 COG2230@1|root,COG2230@2|Bacteria 2|Bacteria M cyclopropane-fatty-acyl-phospholipid synthase cfa1 - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS GZD1_k127_1592038_29 309807.SRU_1452 1.372e-35 146.0 2DRV2@1|root,33D77@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_1592038_36 1463895.JODA01000001_gene530 4.248e-14 79.0 COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria 201174|Actinobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Cupin_3 GZD1_k127_1592038_1 861299.J421_5897 1.896e-184 604.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_5897|- V efflux transmembrane transporter activity - - - - - - - - - - - - - GZD1_k127_1592038_11 267608.RSc2495 2.249e-105 355.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2VN9Y@28216|Betaproteobacteria,1K6AS@119060|Burkholderiaceae 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 GZD1_k127_1592038_21 525367.HMPREF0556_10763 9.405e-50 183.0 COG4430@1|root,COG4430@2|Bacteria,1UYP9@1239|Firmicutes,4HDZD@91061|Bacilli,26JM6@186820|Listeriaceae 91061|Bacilli S Bacteriocin-protection, YdeI or OmpD-Associated ydeI - - - - - - - - - - - DUF1801,OmdA GZD1_k127_1592038_37 861299.J421_1517 3.23e-11 74.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_1517|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_1592038_9 861299.J421_1360 6.84e-108 373.0 COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Multicopper oxidase - - 1.16.3.3 ko:K22348 - - - - ko00000,ko01000 - - - Cu-oxidase_2,Cu-oxidase_3 GZD1_k127_1592038_27 644966.Tmar_0475 2.438e-38 151.0 COG1309@1|root,COG1309@2|Bacteria,1V3QD@1239|Firmicutes,25BU1@186801|Clostridia,3WDJR@538999|Clostridiales incertae sedis 186801|Clostridia K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N GZD1_k127_1592038_6 1379698.RBG1_1C00001G0907 6.384e-125 409.0 COG1024@1|root,COG1024@2|Bacteria 2|Bacteria I Enoyl-CoA hydratase bamA GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 ko:K07539,ko:K18570 ko00332,ko00362,ko01100,ko01120,ko01130,ko01220,map00332,map00362,map01100,map01120,map01130,map01220 M00541 R05593,R05594,R10696,R10750 RC01430,RC01431,RC03237,RC03270 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 GZD1_k127_1592038_20 351607.Acel_1151 7.553e-53 196.0 COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4ERX3@85013|Frankiales 201174|Actinobacteria IQ Short-chain dehydrogenase reductase SDR fabG1 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0018454,GO:0019752,GO:0030497,GO:0032787,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046459,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 ko:K00059,ko:K11610 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GZD1_k127_1592038_24 404380.Gbem_1432 5.686e-42 171.0 COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,42NZQ@68525|delta/epsilon subdivisions,2WMCW@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 GZD1_k127_1592038_8 398767.Glov_2401 2.268e-111 383.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D GZD1_k127_1592038_5 398767.Glov_2400 1.496e-125 414.0 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,430HE@68525|delta/epsilon subdivisions,2WVZI@28221|Deltaproteobacteria,43V4N@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D GZD1_k127_1592038_13 398767.Glov_2399 3.348e-94 317.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales 28221|Deltaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family yjiL - - - - - - - - - - - BcrAD_BadFG GZD1_k127_1592038_19 398767.Glov_2398 7.299e-60 227.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM ATPase, BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG GZD1_k127_1592038_38 706587.Desti_2312 1.793e-08 59.0 2EK17@1|root,33DRQ@2|Bacteria,1NNYN@1224|Proteobacteria,42WT5@68525|delta/epsilon subdivisions,2WSVU@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_1592038_10 1379698.RBG1_1C00001G0892 2.826e-107 359.0 COG1062@1|root,COG1062@2|Bacteria 2|Bacteria C S-(hydroxymethyl)glutathione dehydrogenase activity - - - - - - - - - - - - ADH_N GZD1_k127_1592038_3 1183438.GKIL_4354 1.599e-158 535.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_1592038_25 234267.Acid_4702 5.868e-42 157.0 COG1695@1|root,COG1695@2|Bacteria,3Y4XD@57723|Acidobacteria 57723|Acidobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR GZD1_k127_1592038_31 861299.J421_0639 6.372e-34 134.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR GZD1_k127_1592038_7 861299.J421_6314 7.463e-120 421.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6314|- V efflux transmembrane transporter activity - - - - - - - - - - - - - GZD1_k127_1592038_40 196162.Noca_2193 4.593e-06 55.0 2CRSQ@1|root,32SPK@2|Bacteria,2IQ50@201174|Actinobacteria,4DS85@85009|Propionibacteriales 201174|Actinobacteria S DoxX-like family - - - - - - - - - - - - DoxX_2 GZD1_k127_1592038_14 1267535.KB906767_gene484 5.37e-83 280.0 COG3832@1|root,COG3832@2|Bacteria,3Y4SH@57723|Acidobacteria,2JN2B@204432|Acidobacteriia 204432|Acidobacteriia S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - AHSA1 GZD1_k127_1592038_23 234267.Acid_3036 5.302e-43 159.0 COG0640@1|root,COG0640@2|Bacteria,3Y4ZD@57723|Acidobacteria 57723|Acidobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_5 GZD1_k127_1592038_28 234267.Acid_1133 8.544e-37 156.0 COG4270@1|root,COG4270@2|Bacteria,3Y68W@57723|Acidobacteria 57723|Acidobacteria S DoxX - - - - - - - - - - - - DoxX GZD1_k127_1592038_22 1267533.KB906737_gene1984 5.326e-44 174.0 COG4270@1|root,COG4270@2|Bacteria,3Y68W@57723|Acidobacteria 57723|Acidobacteria S DoxX - - - - - - - - - - - - DoxX GZD1_k127_1592038_26 485913.Krac_2611 2.499e-40 158.0 2BHPS@1|root,32BT1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_1592038_18 42565.FP66_13215 1.705e-72 252.0 COG2085@1|root,COG2085@2|Bacteria,1MV62@1224|Proteobacteria,1RY91@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored GZD1_k127_1592038_42 153721.MYP_2859 0.0003156 48.0 COG5646@1|root,COG5646@2|Bacteria,4NSDH@976|Bacteroidetes,47R0R@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 GZD1_k127_1592038_30 861299.J421_1513 2.422e-34 149.0 2CWY1@1|root,32T0M@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_1592038_16 1379270.AUXF01000002_gene1233 9.853e-76 263.0 COG0457@1|root,COG2133@1|root,COG0457@2|Bacteria,COG2133@2|Bacteria,1ZUVC@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 GZD1_k127_1592038_32 485913.Krac_5706 8.874e-33 138.0 COG0596@1|root,COG0596@2|Bacteria,2G8UW@200795|Chloroflexi 200795|Chloroflexi S PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 GZD1_k127_1592038_17 1254432.SCE1572_35595 1.051e-73 258.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2Z316@29|Myxococcales 28221|Deltaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA GZD1_k127_1592038_2 1379270.AUXF01000004_gene3069 2.12e-161 540.0 28M0D@1|root,2ZAFE@2|Bacteria,1ZUP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative ATP-binding cassette - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran_2 GZD1_k127_1592038_12 1379270.AUXF01000004_gene3068 1.988e-98 329.0 COG1131@1|root,COG1131@2|Bacteria,1ZUPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_1592038_34 177437.HRM2_33700 4.99e-21 108.0 COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,2MJNR@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM transglutaminase domain protein - - - - - - - - - - - - Transglut_core GZD1_k127_1592038_41 1297570.MESS4_450012 4.993e-06 55.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria 28211|Alphaproteobacteria U COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_2,TPR_8 GZD1_k127_1592038_33 861299.J421_2745 2.838e-26 111.0 COG1324@1|root,COG1324@2|Bacteria,1ZV6V@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CutA1 divalent ion tolerance protein - - - ko:K03926 - - - - ko00000 - - - CutA1 GZD1_k127_1592038_0 861299.J421_2748 0.0 1414.0 COG0178@1|root,COG0178@2|Bacteria,1ZTDJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran GZD1_k127_1592038_15 1379270.AUXF01000004_gene3061 2.121e-82 281.0 COG1842@1|root,COG1842@2|Bacteria,1ZT82@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PspA/IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 GZD1_k127_1592038_39 309801.trd_A0004 4.227e-06 56.0 COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi,27Y2E@189775|Thermomicrobia 189775|Thermomicrobia S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport GZD1_k127_1596954_13 266117.Rxyl_0743 3.322e-147 476.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CPTD@84995|Rubrobacteria 84995|Rubrobacteria HP UBA THIF-type NAD FAD binding - - 2.7.7.80,2.8.1.11 ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF GZD1_k127_1596954_52 379066.GAU_1983 1.482e-51 186.0 COG1959@1|root,COG1959@2|Bacteria,1ZTRG@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulator - - - - - - - - - - - - Rrf2 GZD1_k127_1596954_10 1379270.AUXF01000003_gene3872 3.752e-196 622.0 COG1027@1|root,COG1027@2|Bacteria,1ZSUY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 GZD1_k127_1596954_81 861299.J421_1604 2.795e-06 59.0 COG0392@1|root,COG0392@2|Bacteria,1ZSUQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GZD1_k127_1596954_49 1489678.RDMS_09375 4.989e-55 203.0 COG0491@1|root,COG0491@2|Bacteria,1WIMP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - - - - - - - - - - Lactamase_B GZD1_k127_1596954_32 1123284.KB899045_gene2557 1.243e-89 306.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,26NMP@186821|Sporolactobacillaceae 91061|Bacilli C FAD dependent oxidoreductase trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 GZD1_k127_1596954_80 710696.Intca_2705 2.885e-07 58.0 COG1547@1|root,COG1547@2|Bacteria,2IHUS@201174|Actinobacteria,4FH6W@85021|Intrasporangiaceae 201174|Actinobacteria S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 GZD1_k127_1596954_53 1379270.AUXF01000003_gene3868 6.906e-51 191.0 2AEWX@1|root,314UJ@2|Bacteria,1ZUPP@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_1596954_45 861299.J421_3591 1.251e-68 241.0 COG1028@1|root,COG1028@2|Bacteria,1ZTNC@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 GZD1_k127_1596954_62 861299.J421_0461 1.191e-34 146.0 COG1028@1|root,COG1028@2|Bacteria,1ZTWE@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 GZD1_k127_1596954_47 861299.J421_3592 3.276e-59 216.0 COG0613@1|root,COG0613@2|Bacteria,1ZTHM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP GZD1_k127_1596954_74 861299.J421_3593 1.215e-15 86.0 2FHQX@1|root,349IG@2|Bacteria,1ZU2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_1596954_18 1121920.AUAU01000004_gene789 1.042e-129 428.0 COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria 57723|Acidobacteria C e3 binding domain - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding GZD1_k127_1596954_12 861299.J421_3597 5.174e-156 501.0 COG0022@1|root,COG0022@2|Bacteria,1ZT89@142182|Gemmatimonadetes 2|Bacteria C Transketolase, pyrimidine binding domain bfmBA - 1.2.4.4 ko:K00167,ko:K11381,ko:K21417 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C GZD1_k127_1596954_16 861299.J421_3598 3.19e-133 433.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 2|Bacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C GZD1_k127_1596954_76 1489678.RDMS_09620 7.357e-11 65.0 COG2608@1|root,COG2608@2|Bacteria,1WKNR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Heavy metal transport detoxification protein - - - - - - - - - - - - HMA GZD1_k127_1596954_72 861299.J421_3599 3.284e-19 91.0 2FD8C@1|root,345AC@2|Bacteria,1ZTXK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_1596954_9 351160.RCIX1517 3.473e-216 699.0 COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia 224756|Methanomicrobia P ATPase, P-type (transporting), HAD superfamily, subfamily IC copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase GZD1_k127_1596954_64 1210884.HG799462_gene9161 4.322e-32 129.0 COG4633@1|root,COG4633@2|Bacteria 2|Bacteria - - silP - 1.9.3.1,3.6.3.54 ko:K02275,ko:K17686 ko00190,ko01100,ko01524,ko04016,map00190,map01100,map01524,map04016 M00155 R00081,R00086 RC00002,RC00016 ko00000,ko00001,ko00002,ko01000 3.A.3.5,3.D.4.2,3.D.4.4,3.D.4.6 - - Cupredoxin_1,DsbD_2,HMA GZD1_k127_1596954_2 1267535.KB906767_gene2605 0.0 1224.0 COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia 204432|Acidobacteriia C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase GZD1_k127_1596954_8 861299.J421_3601 7.916e-219 686.0 COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 GZD1_k127_1596954_61 861299.J421_3602 1.008e-38 155.0 COG0558@1|root,COG0558@2|Bacteria,1ZTIP@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf GZD1_k127_1596954_35 420246.GTNG_1290 4.83e-82 297.0 COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,1WFX8@129337|Geobacillus 91061|Bacilli S Protein of unknown function (DUF1343) ybbC - - - - - - - - - - - DUF1343 GZD1_k127_1596954_23 861299.J421_3604 1.308e-112 389.0 COG1472@1|root,COG1472@2|Bacteria,1ZTD2@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C GZD1_k127_1596954_34 379066.GAU_2000 3.198e-87 308.0 COG1680@1|root,COG1680@2|Bacteria,1ZT58@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase GZD1_k127_1596954_58 1379270.AUXF01000003_gene3855 3.408e-40 152.0 COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn GZD1_k127_1596954_19 861299.J421_3608 9.837e-128 424.0 COG0591@1|root,COG0591@2|Bacteria,1ZTEB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Sodium:solute symporter family - - - - - - - - - - - - SSF GZD1_k127_1596954_59 861299.J421_3609 6.378e-40 171.0 COG2971@1|root,COG2971@2|Bacteria,1ZT52@142182|Gemmatimonadetes 142182|Gemmatimonadetes G BadF/BadG/BcrA/BcrD ATPase family - - 2.7.1.8 ko:K18676 ko00520,ko01100,map00520,map01100 - R01961 RC00002,RC00017 ko00000,ko00001,ko01000 - - - BcrAD_BadFG GZD1_k127_1596954_14 861299.J421_3612 1.145e-144 473.0 COG0531@1|root,COG0531@2|Bacteria,1ZT2B@142182|Gemmatimonadetes 142182|Gemmatimonadetes E C-terminus of AA_permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GZD1_k127_1596954_65 861299.J421_3615 6.66e-31 126.0 COG0848@1|root,COG0848@2|Bacteria,1ZTXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD GZD1_k127_1596954_75 272942.RCAP_rcc03198 3.7e-13 76.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,1FBSH@1060|Rhodobacter 28211|Alphaproteobacteria U PFAM Biopolymer transport protein ExbD TolR tolR - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD GZD1_k127_1596954_31 861299.J421_3617 5.458e-91 306.0 COG0811@1|root,COG0811@2|Bacteria,1ZTH1@142182|Gemmatimonadetes 142182|Gemmatimonadetes U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB GZD1_k127_1596954_78 1453500.AT05_00565 4.122e-08 63.0 COG0810@1|root,COG0810@2|Bacteria,4NMG7@976|Bacteroidetes,1HX5H@117743|Flavobacteriia 976|Bacteroidetes M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C GZD1_k127_1596954_82 1205753.A989_07567 1.251e-05 57.0 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S2VT@1236|Gammaproteobacteria,1XCIY@135614|Xanthomonadales 135614|Xanthomonadales M COG0810 Periplasmic protein TonB, links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C GZD1_k127_1596954_83 1242864.D187_002607 0.0006157 51.0 COG0810@1|root,COG0810@2|Bacteria,1NDQZ@1224|Proteobacteria,42VIY@68525|delta/epsilon subdivisions,2WRTC@28221|Deltaproteobacteria,2Z1BM@29|Myxococcales 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C GZD1_k127_1596954_27 379066.GAU_2012 1.629e-103 353.0 COG5002@1|root,COG5002@2|Bacteria,1ZTF2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA GZD1_k127_1596954_30 861299.J421_3620 4.61e-96 325.0 COG0745@1|root,COG0745@2|Bacteria,1ZT8B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C GZD1_k127_1596954_20 861299.J421_3622 6.632e-127 422.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1ZTDZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 GZD1_k127_1596954_68 1396141.BATP01000035_gene4002 4.03e-27 129.0 COG3345@1|root,COG3345@2|Bacteria,46XPU@74201|Verrucomicrobia,2IWC9@203494|Verrucomicrobiae 203494|Verrucomicrobiae G Beta-galactosidase - - - - - - - - - - - - Melibiase GZD1_k127_1596954_63 525245.HMPREF0044_0551 2.116e-33 142.0 COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria,4D83K@85005|Actinomycetales 201174|Actinobacteria P ABC transporter permease - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 GZD1_k127_1596954_70 994479.GL877878_gene585 1.272e-25 123.0 COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4E4P4@85010|Pseudonocardiales 201174|Actinobacteria G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 GZD1_k127_1596954_33 479434.Sthe_2060 2.208e-87 300.0 COG3842@1|root,COG3842@2|Bacteria,2G5X9@200795|Chloroflexi,27XY7@189775|Thermomicrobia 189775|Thermomicrobia P TOBE domain - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 GZD1_k127_1596954_41 861299.J421_4103 1.319e-72 263.0 COG0515@1|root,COG5184@1|root,COG0515@2|Bacteria,COG5184@2|Bacteria,1ZUHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes DKLTZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Pkinase,RCC1 GZD1_k127_1596954_50 861299.J421_3623 1.951e-54 197.0 COG1225@1|root,COG1225@2|Bacteria,1ZTY4@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA GZD1_k127_1596954_28 1120972.AUMH01000009_gene418 4.527e-98 324.0 COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,2781X@186823|Alicyclobacillaceae 91061|Bacilli P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N GZD1_k127_1596954_26 405948.SACE_2164 1.403e-110 370.0 COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4E09P@85010|Pseudonocardiales 201174|Actinobacteria C NADPH quinone reductase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N GZD1_k127_1596954_79 290397.Adeh_0555 1.865e-07 59.0 2AGZU@1|root,3178K@2|Bacteria,1PYIG@1224|Proteobacteria,43E50@68525|delta/epsilon subdivisions,2WZR6@28221|Deltaproteobacteria,2Z2JU@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_1596954_66 309801.trd_1752 8.928e-30 131.0 COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi,27YI4@189775|Thermomicrobia 189775|Thermomicrobia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_1596954_43 748247.AZKH_2905 2.259e-70 249.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2VQ5Z@28216|Betaproteobacteria,2KUJK@206389|Rhodocyclales 206389|Rhodocyclales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH padA - - ko:K02379,ko:K18360 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001 - - - FdhD-NarQ GZD1_k127_1596954_17 208439.AJAP_16970 7.838e-131 428.0 COG3383@1|root,COG3383@2|Bacteria,2GKBP@201174|Actinobacteria,4DXFK@85010|Pseudonocardiales 201174|Actinobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3 GZD1_k127_1596954_7 446468.Ndas_4112 4.19e-232 733.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4EI2I@85012|Streptosporangiales 201174|Actinobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.17.1.9,1.6.5.3 ko:K00122,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB GZD1_k127_1596954_6 1122611.KB903977_gene2806 3.18e-234 736.0 COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4EGXK@85012|Streptosporangiales 201174|Actinobacteria C Molybdopterin oxidoreductase fdnG - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding GZD1_k127_1596954_67 287986.DV20_36375 1.004e-27 115.0 COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DZUH@85010|Pseudonocardiales 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdnG - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding GZD1_k127_1596954_1 861299.J421_1964 0.0 1291.0 COG0841@1|root,COG0841@2|Bacteria 2|Bacteria V transmembrane transporter activity swrC - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran GZD1_k127_1596954_57 861299.J421_1963 9.27e-44 177.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 GZD1_k127_1596954_42 861299.J421_1961 7.111e-72 257.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP GZD1_k127_1596954_24 861299.J421_1960 1.437e-111 381.0 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - HATPase_c,HisKA GZD1_k127_1596954_54 2325.TKV_c17200 1.365e-47 178.0 COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,42G7G@68295|Thermoanaerobacterales 186801|Clostridia K PFAM response regulator receiver mprA - - - - - - - - - - - Response_reg,Trans_reg_C GZD1_k127_1596954_11 1089548.KI783301_gene1899 4.163e-160 518.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HANQ@91061|Bacilli,3WFAP@539002|Bacillales incertae sedis 91061|Bacilli H intramolecular transferase activity, transferring amino groups hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iSB619.SA_RS08395 Aminotran_3 GZD1_k127_1596954_25 479434.Sthe_2327 1.061e-110 374.0 COG1232@1|root,COG1232@2|Bacteria,2G687@200795|Chloroflexi,27XMR@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase GZD1_k127_1596954_38 479434.Sthe_2326 2.624e-79 278.0 COG0276@1|root,COG0276@2|Bacteria,2G6A2@200795|Chloroflexi,27XJN@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase GZD1_k127_1596954_15 479434.Sthe_2324 1.214e-134 447.0 COG0407@1|root,COG0407@2|Bacteria,2G5NU@200795|Chloroflexi,27XWH@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D GZD1_k127_1596954_60 661478.OP10G_0939 5.977e-39 156.0 COG3253@1|root,COG3253@2|Bacteria 2|Bacteria S peroxidase activity - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 ko:K09162 - - - - ko00000,ko01000 - - - Chlor_dismutase GZD1_k127_1596954_22 326427.Cagg_1291 3.786e-113 380.0 COG0113@1|root,COG0113@2|Bacteria,2G5QT@200795|Chloroflexi,3756C@32061|Chloroflexia 32061|Chloroflexia H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD GZD1_k127_1596954_55 706587.Desti_2598 2.234e-44 177.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2MQX4@213462|Syntrophobacterales 28221|Deltaproteobacteria H Belongs to the precorrin methyltransferase family hemD - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase GZD1_k127_1596954_40 861299.J421_4276 8.046e-73 256.0 COG0181@1|root,COG0181@2|Bacteria,1ZTQF@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC GZD1_k127_1596954_37 1128421.JAGA01000001_gene2430 8.956e-80 282.0 COG0373@1|root,COG0373@2|Bacteria,2NP37@2323|unclassified Bacteria 2|Bacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0005575,GO:0005623,GO:0008150,GO:0009288,GO:0040007,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492,ko:K10714,ko:K15671 ko00680,ko00860,ko01051,ko01052,ko01100,ko01110,ko01120,ko01200,ko02040,map00680,map00860,map01051,map01052,map01100,map01110,map01120,map01200,map02040 M00121 R04109,R08059 RC00055,RC00149,RC00202 ko00000,ko00001,ko00002,ko01000,ko01008,ko02035 - - iSB619.SA_RS08420 GlutR_N,GlutR_dimer,Mpt_N,Shikimate_DH GZD1_k127_1596954_46 379066.GAU_2230 2.871e-66 238.0 COG2197@1|root,COG2197@2|Bacteria,1ZTJ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg GZD1_k127_1596954_21 861299.J421_0271 3.743e-121 402.0 COG4585@1|root,COG4585@2|Bacteria,1ZSM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Histidine kinase - - - - - - - - - - - - HisKA_3 GZD1_k127_1596954_73 309807.SRU_2828 4.718e-18 90.0 2DBIE@1|root,32ZYG@2|Bacteria,4PM6T@976|Bacteroidetes,1FJJR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes - - - - - - - - - - - - - - - GZD1_k127_1596954_29 1250005.PHEL85_1343 2.171e-97 338.0 COG0471@1|root,COG0471@2|Bacteria,4NFDK@976|Bacteroidetes,1HX3U@117743|Flavobacteriia,3VV80@52959|Polaribacter 976|Bacteroidetes P Di- and tricarboxylate transporters - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp GZD1_k127_1596954_51 504728.K649_08970 1.095e-52 193.0 COG2954@1|root,COG2954@2|Bacteria 2|Bacteria S triphosphatase activity cyaA GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0050355 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH GZD1_k127_1596954_44 1049564.TevJSym_ab00120 9.729e-69 249.0 COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,1S2UH@1236|Gammaproteobacteria,1J6KU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Phosphate-selective porin O and P oprP - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P GZD1_k127_1596954_69 595536.ADVE02000001_gene1041 1.104e-26 118.0 2AEQ2@1|root,314KC@2|Bacteria,1R42T@1224|Proteobacteria,2UMV3@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_1596954_36 379066.GAU_3854 6.939e-81 285.0 COG3174@1|root,COG3174@2|Bacteria,1ZUTX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC GZD1_k127_1596954_3 861299.J421_0704 0.0 1038.0 COG0577@1|root,COG0577@2|Bacteria,1ZUI2@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_1596954_39 1191523.MROS_2208 6.33e-73 273.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor irp - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec GZD1_k127_1596954_0 661478.OP10G_1148 0.0 1337.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Sortilin-Vps10 GZD1_k127_1596954_5 861299.J421_4121 4.464e-237 755.0 COG5276@1|root,COG5276@2|Bacteria,1ZTC3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LVIVD repeat - - - - - - - - - - - - LVIVD GZD1_k127_1596954_56 861299.J421_4120 3.31e-44 167.0 COG3544@1|root,COG3544@2|Bacteria,1ZTPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 GZD1_k127_1596954_48 861299.J421_4120 4.974e-57 208.0 COG3544@1|root,COG3544@2|Bacteria,1ZTPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 GZD1_k127_1596954_4 861299.J421_4121 1.404e-266 846.0 COG5276@1|root,COG5276@2|Bacteria,1ZTC3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LVIVD repeat - - - - - - - - - - - - LVIVD GZD1_k127_1596954_77 113395.AXAI01000041_gene6366 1.525e-09 72.0 COG3391@1|root,COG3391@2|Bacteria,1MWUF@1224|Proteobacteria,2U1IX@28211|Alphaproteobacteria,3JV0F@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T amine dehydrogenase activity - - - - - - - - - - - - - GZD1_k127_1596954_71 861299.J421_2924 2.235e-21 111.0 COG4932@1|root,COG4932@2|Bacteria,1ZUFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M domain protein - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - - GZD1_k127_1620185_2 379066.GAU_1894 5.988e-24 102.0 COG0828@1|root,COG0828@2|Bacteria,1ZU81@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S21 - - - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 GZD1_k127_1620185_1 861299.J421_3464 7.237e-36 141.0 COG1610@1|root,COG1610@2|Bacteria,1ZTS3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY GZD1_k127_1620185_0 1379270.AUXF01000006_gene68 1.503e-95 335.0 COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr GZD1_k127_1649204_14 1379698.RBG1_1C00001G0252 3.194e-30 123.0 COG2323@1|root,COG2323@2|Bacteria,2NR09@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF421) - - - - - - - - - - - - DUF421 GZD1_k127_1649204_6 861299.J421_3854 4.891e-111 375.0 COG0544@1|root,COG0544@2|Bacteria,1ZSSF@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig - - ko:K03545 - - - - ko00000 - - - Trigger_C,Trigger_N GZD1_k127_1649204_8 457415.HMPREF1006_00247 1.588e-78 268.0 COG0740@1|root,COG0740@2|Bacteria,3T9R6@508458|Synergistetes 508458|Synergistetes O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease GZD1_k127_1649204_1 1379270.AUXF01000003_gene3513 3.083e-214 672.0 COG1219@1|root,COG1219@2|Bacteria,1ZT8F@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX GZD1_k127_1649204_12 661087.HMPREF1008_00590 9.617e-32 134.0 COG0218@1|root,COG0218@2|Bacteria,2HUS4@201174|Actinobacteria,4CVHX@84998|Coriobacteriia 84998|Coriobacteriia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 GZD1_k127_1649204_15 861299.J421_3859 7.199e-29 124.0 2F4EZ@1|root,33X55@2|Bacteria,1ZTSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_1649204_7 1521187.JPIM01000051_gene3470 1.468e-89 322.0 COG0745@1|root,COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg GZD1_k127_1649204_16 861299.J421_2050 6.613e-21 104.0 COG3695@1|root,COG3695@2|Bacteria 2|Bacteria L enzyme binding ogt - 2.1.1.63 ko:K00567,ko:K07443 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,YjbR GZD1_k127_1649204_13 861299.J421_3863 1.417e-31 130.0 COG0494@1|root,COG0494@2|Bacteria,1ZTYK@142182|Gemmatimonadetes 142182|Gemmatimonadetes L NUDIX domain - - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX GZD1_k127_1649204_3 861299.J421_3864 1.317e-146 491.0 COG2804@1|root,COG2804@2|Bacteria,1ZT2F@142182|Gemmatimonadetes 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N GZD1_k127_1649204_4 861299.J421_3866 2.531e-118 416.0 2EWAK@1|root,33PPB@2|Bacteria,1ZT00@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_1649204_2 379066.GAU_2416 2.693e-148 486.0 COG0147@1|root,COG0147@2|Bacteria,1ZSPU@142182|Gemmatimonadetes 142182|Gemmatimonadetes EH Anthranilate synthase component I, N terminal region trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind GZD1_k127_1649204_5 861299.J421_3868 3.253e-117 396.0 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1ZT7U@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,GAF,Guanylate_cyc GZD1_k127_1649204_10 682795.AciX8_0031 3.441e-54 196.0 COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria,2JJH8@204432|Acidobacteriia 204432|Acidobacteriia D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf GZD1_k127_1649204_11 1121346.KB899811_gene1646 2.649e-42 174.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,26XEB@186822|Paenibacillaceae 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase GZD1_k127_1649204_0 861299.J421_3893 9.006e-259 817.0 COG0449@1|root,COG0449@2|Bacteria,1ZSTI@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS GZD1_k127_1649204_9 861299.J421_3894 2.528e-61 217.0 COG1109@1|root,COG1109@2|Bacteria,1ZSNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV GZD1_k127_180581_4 742817.HMPREF9449_01289 9.045e-37 144.0 COG2235@1|root,COG2235@2|Bacteria 2|Bacteria E arginine - - 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 - R00552 RC00177 ko00000,ko00001,ko01000 - - - Amidinotransf GZD1_k127_180581_1 1379270.AUXF01000006_gene81 7.656e-104 345.0 COG0491@1|root,COG0491@2|Bacteria,1ZT7V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B GZD1_k127_180581_2 379066.GAU_1878 5.874e-70 242.0 COG0290@1|root,COG0290@2|Bacteria,1ZTM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N GZD1_k127_180581_6 1033802.SSPSH_002878 6.655e-15 76.0 COG0291@1|root,COG0291@2|Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p GZD1_k127_180581_3 379066.GAU_1876 1.047e-45 167.0 COG0292@1|root,COG0292@2|Bacteria,1ZTUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 GZD1_k127_180581_0 379066.GAU_1875 1.989e-104 351.0 COG0016@1|root,COG0016@2|Bacteria,1ZSQR@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Aminoacyl tRNA synthetase class II, N-terminal domain pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d GZD1_k127_180581_5 379066.GAU_1874 7.022e-32 140.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1ZSWJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J B3/4 domain pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind GZD1_k127_1869549_1 1356852.N008_04995 1.35e-45 182.0 COG1215@1|root,COG1215@2|Bacteria,4NFI8@976|Bacteroidetes,47PPF@768503|Cytophagia 976|Bacteroidetes M Pfam:DUF2029 - - - - - - - - - - - - GT87 GZD1_k127_1869549_3 204669.Acid345_1509 4.089e-16 80.0 293PJ@1|root,2ZR58@2|Bacteria,3Y96W@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - GZD1_k127_1869549_0 861299.J421_4130 1.688e-157 528.0 COG1629@1|root,COG4771@2|Bacteria,1ZVAQ@142182|Gemmatimonadetes 2|Bacteria P TonB dependent receptor susC - - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_1869549_2 1123252.ATZF01000005_gene4072 2.457e-23 111.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,27B40@186824|Thermoactinomycetaceae 91061|Bacilli KLT Protein tyrosine kinase prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase GZD1_k127_1886416_14 379066.GAU_0474 5.592e-14 73.0 COG1595@1|root,COG1595@2|Bacteria,1ZSWF@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_1886416_7 309807.SRU_2758 1.4e-18 95.0 COG0296@1|root,COG0296@2|Bacteria 2|Bacteria G 1,4-alpha-glucan branching enzyme activity - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - AMPK1_CBM,Alpha-amylase,Alpha-amylase_C,CBM_48 GZD1_k127_1886416_17 861299.J421_4539 5.131e-06 57.0 28YSJ@1|root,2ZKJZ@2|Bacteria,1ZU1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_1886416_3 383372.Rcas_3355 4.936e-98 334.0 COG1364@1|root,COG1364@2|Bacteria,2G64K@200795|Chloroflexi,37529@32061|Chloroflexia 32061|Chloroflexia E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate - - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ GZD1_k127_1886416_2 861299.J421_4211 6.722e-141 458.0 COG0457@1|root,COG0457@2|Bacteria,1ZSYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2 GZD1_k127_1886416_15 1122919.KB905567_gene2777 6.782e-10 65.0 COG2259@1|root,COG2259@2|Bacteria,1VCS2@1239|Firmicutes,4HKRK@91061|Bacilli,26YZ6@186822|Paenibacillaceae 91061|Bacilli S membrane yfiD3 - - - - - - - - - - - DoxX GZD1_k127_1886416_18 861299.J421_4104 2.547e-05 56.0 COG5492@1|root,COG5492@2|Bacteria,1ZUE7@142182|Gemmatimonadetes 142182|Gemmatimonadetes N Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 GZD1_k127_1886416_4 1144275.COCOR_01981 1.271e-41 158.0 COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2YVI9@29|Myxococcales 28221|Deltaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding GZD1_k127_1886416_12 1144275.COCOR_00129 1.231e-17 89.0 COG0558@1|root,COG0558@2|Bacteria,1P9BV@1224|Proteobacteria,432CD@68525|delta/epsilon subdivisions,2WX7J@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf GZD1_k127_1886416_13 1399115.U719_06130 1.933e-15 85.0 COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,4HJHJ@91061|Bacilli,3WFM6@539002|Bacillales incertae sedis 91061|Bacilli O OsmC-like protein - - - ko:K07397 - - - - ko00000 - - - OsmC GZD1_k127_1886416_8 861299.J421_4201 4.216e-18 87.0 2CA00@1|root,344QM@2|Bacteria,1ZU1Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_1886416_6 1379270.AUXF01000001_gene2790 5.395e-30 131.0 COG1651@1|root,COG1651@2|Bacteria,1ZTKP@142182|Gemmatimonadetes 142182|Gemmatimonadetes O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 GZD1_k127_1886416_11 292459.STH2564 1.104e-17 93.0 COG4243@1|root,COG4243@2|Bacteria 2|Bacteria S quinone binding - - - - - - - - - - - - Thioredoxin_4,VKOR GZD1_k127_1886416_1 635013.TherJR_2465 1.75e-180 583.0 COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,249N1@186801|Clostridia,260S4@186807|Peptococcaceae 186801|Clostridia E amino acid - - - - - - - - - - - - AA_permease_2 GZD1_k127_1886416_0 1121468.AUBR01000064_gene947 2.205e-298 927.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24E00@186801|Clostridia,42FQ1@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C GZD1_k127_1886416_16 861299.J421_3455 7.004e-07 55.0 COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS GZD1_k127_1886416_10 909663.KI867150_gene1503 1.051e-17 87.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42PH1@68525|delta/epsilon subdivisions,2WKMX@28221|Deltaproteobacteria,2MRDV@213462|Syntrophobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_1886416_5 1408254.T458_12940 1.108e-35 141.0 COG4555@1|root,COG4555@2|Bacteria,1UHYH@1239|Firmicutes,4ISGA@91061|Bacilli,274EX@186822|Paenibacillaceae 91061|Bacilli CP ATPases associated with a variety of cellular activities natA - 3.6.3.7 ko:K01990,ko:K09697 ko02010,ko02020,map02010,map02020 M00253,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.115 - iYO844.BSU02750 ABC_tran GZD1_k127_1897602_0 1229780.BN381_250012 2.9e-123 408.0 COG3464@1|root,COG3464@2|Bacteria,2I56J@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - - GZD1_k127_1897602_1 1463900.JOIX01000011_gene3266 1.389e-05 54.0 2BXKD@1|root,33EXH@2|Bacteria,2I9MS@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - GZD1_k127_1905997_1 1237149.C900_05550 9.726e-267 840.0 COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia 976|Bacteroidetes EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 GZD1_k127_1905997_3 861299.J421_6087 1.75e-215 690.0 COG2936@1|root,COG2936@2|Bacteria,1ZTD6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 GZD1_k127_1905997_10 861299.J421_0867 9.385e-146 493.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0867|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - GZD1_k127_1905997_18 861299.J421_0722 1.718e-75 264.0 COG2755@1|root,COG2755@2|Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL_2 GZD1_k127_1905997_11 661478.OP10G_2391 9.415e-142 466.0 COG1409@1|root,COG3669@1|root,COG1409@2|Bacteria,COG3669@2|Bacteria 2|Bacteria G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C,PA14 GZD1_k127_1905997_6 518766.Rmar_1740 8.273e-177 564.0 COG0673@1|root,COG0673@2|Bacteria,4NEN5@976|Bacteroidetes,1FK20@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA GZD1_k127_1905997_9 1379270.AUXF01000005_gene356 2.185e-158 509.0 COG0477@1|root,COG2814@2|Bacteria,1ZTDQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes EGP Nucleoside H+ symporter - - - - - - - - - - - - Nuc_H_symport GZD1_k127_1905997_23 351607.Acel_0042 1.837e-30 126.0 COG1765@1|root,COG1765@2|Bacteria,2HA74@201174|Actinobacteria 201174|Actinobacteria O OsmC-like protein - - - - - - - - - - - - OsmC GZD1_k127_1905997_22 861299.J421_1380 1.131e-46 194.0 COG3142@1|root,COG3142@2|Bacteria,1ZTRQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Participates in the control of copper homeostasis cutC - - ko:K06201 - - - - ko00000 - - - CutC GZD1_k127_1905997_14 1379698.RBG1_1C00001G0798 4.065e-98 350.0 COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - HEAT_2,Peptidase_M1 GZD1_k127_1905997_8 861299.J421_0708 2.087e-163 525.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - ko:K08178 - - - - ko00000,ko02000 2.A.1.12 - - MFS_1,Sugar_tr GZD1_k127_1905997_16 1382359.JIAL01000001_gene2993 9.495e-97 325.0 2B47E@1|root,31WYM@2|Bacteria,3Y45I@57723|Acidobacteria,2JIH8@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - GZD1_k127_1905997_0 861299.J421_0107 0.0 1048.0 COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1ZUIV@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM Glycosyl hydrolases family 18 - - - - - - - - - - - - Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1 GZD1_k127_1905997_12 1144275.COCOR_07436 5.888e-141 457.0 COG3239@1|root,COG3239@2|Bacteria,1QKDT@1224|Proteobacteria 1224|Proteobacteria I fatty acid desaturase - - 1.14.19.3 ko:K00508 ko00591,ko01100,map00591,map01100 - R07063 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase GZD1_k127_1905997_4 604331.AUHY01000015_gene2634 1.724e-196 622.0 COG2224@1|root,COG2224@2|Bacteria,1WI8Z@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL GZD1_k127_1905997_2 1122223.KB890696_gene364 1.561e-228 719.0 COG2225@1|root,COG2225@2|Bacteria,1WIVZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Belongs to the malate synthase family - - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase GZD1_k127_1905997_5 1382356.JQMP01000003_gene1584 1.926e-186 611.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia 189775|Thermomicrobia C Succinyl-CoA ligase like flavodoxin domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig GZD1_k127_1905997_19 1082933.MEA186_33459 2.218e-70 251.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TT05@28211|Alphaproteobacteria,43K9J@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P flavoprotein involved in K transport trxBch - 1.14.13.168 ko:K11816 ko00380,ko01100,map00380,map01100 - R10181 RC00866 ko00000,ko00001,ko01000 - - - FMO-like,K_oxygenase,Pyr_redox_3 GZD1_k127_1905997_7 526225.Gobs_1168 5.622e-168 539.0 COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4ES6C@85013|Frankiales 201174|Actinobacteria E PFAM Pyridoxal-dependent decarboxylase - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC GZD1_k127_1905997_15 1415780.JPOG01000001_gene961 7.782e-97 342.0 COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,1RPS8@1236|Gammaproteobacteria,1X78Y@135614|Xanthomonadales 135614|Xanthomonadales E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N GZD1_k127_1905997_13 1207063.P24_14749 1.118e-110 368.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,2JPEG@204441|Rhodospirillales 204441|Rhodospirillales FL 6-O-methylguanine DNA methyltransferase, DNA binding domain - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N GZD1_k127_1905997_17 945713.IALB_3148 3.289e-78 278.0 2CESB@1|root,2Z8UZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF481 GZD1_k127_1905997_20 1267533.KB906737_gene1752 1.083e-56 211.0 COG1131@1|root,COG1131@2|Bacteria,3Y50U@57723|Acidobacteria,2JM9C@204432|Acidobacteriia 204432|Acidobacteriia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_1905997_21 861299.J421_4448 5.138e-50 187.0 COG0515@1|root,COG0515@2|Bacteria,1ZTGN@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Protein kinase domain - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_1927663_0 682795.AciX8_4354 2.57e-105 362.0 COG3315@1|root,COG3315@2|Bacteria 2|Bacteria Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - - - - - - - - - - LCM,Methyltransf_19 GZD1_k127_1927663_1 290397.Adeh_3668 2.359e-102 347.0 COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,42UIK@68525|delta/epsilon subdivisions,2X5D2@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger GZD1_k127_1927663_2 861299.J421_1864 1.038e-95 336.0 COG0038@1|root,COG0038@2|Bacteria 2|Bacteria P chloride channel clcA - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC GZD1_k127_1927663_4 1144319.PMI16_00017 9.192e-09 57.0 COG2197@1|root,COG2197@2|Bacteria,1RH8D@1224|Proteobacteria,2WEH4@28216|Betaproteobacteria,4778U@75682|Oxalobacteraceae 28216|Betaproteobacteria K PFAM Response regulator receiver domain, Bacterial regulatory proteins, luxR family - - - - - - - - - - - - GerE,Response_reg GZD1_k127_1948463_4 1183438.GKIL_4354 2.986e-144 485.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_1948463_1 234267.Acid_2214 3.486e-179 592.0 COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_1948463_2 234267.Acid_2489 4.789e-175 577.0 COG0577@1|root,COG0577@2|Bacteria,3Y402@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_1948463_8 861299.J421_0284 1.89e-103 339.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_1948463_3 452637.Oter_1883 3.748e-160 533.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_1948463_7 379066.GAU_3078 9.588e-115 375.0 COG1136@1|root,COG1136@2|Bacteria,1ZUP7@142182|Gemmatimonadetes 142182|Gemmatimonadetes V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_1948463_6 379066.GAU_3079 1.243e-128 423.0 COG0845@1|root,COG0845@2|Bacteria,1ZUP2@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_3 GZD1_k127_1948463_14 755731.Clo1100_3318 1.355e-16 92.0 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,36E8H@31979|Clostridiaceae 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM GZD1_k127_1948463_9 448385.sce3387 3.547e-101 359.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - GZD1_k127_1948463_15 1123267.JONN01000001_gene2454 2.651e-14 85.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,2K1NT@204457|Sphingomonadales 204457|Sphingomonadales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N GZD1_k127_1948463_20 518766.Rmar_1585 0.0003809 52.0 COG1493@1|root,COG1493@2|Bacteria,4P7YQ@976|Bacteroidetes 976|Bacteroidetes T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - - - - - - - - - - - GZD1_k127_1948463_18 1238182.C882_1566 7.262e-05 55.0 28JAH@1|root,2Z95A@2|Bacteria,1MXKT@1224|Proteobacteria,2U1QQ@28211|Alphaproteobacteria,2JS9U@204441|Rhodospirillales 204441|Rhodospirillales S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 GZD1_k127_1948463_0 861299.J421_4386 1.884e-203 656.0 COG2234@1|root,COG2234@2|Bacteria,1ZSXY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 GZD1_k127_1948463_13 861299.J421_2221 1.516e-42 171.0 2ECQU@1|root,336NI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PHP GZD1_k127_1948463_17 1267534.KB906755_gene4277 1.674e-08 64.0 2F7F1@1|root,33ZVU@2|Bacteria,3Y85X@57723|Acidobacteria,2JN8D@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function (DUF1569) - - - - - - - - - - - - DUF1569,DinB_2 GZD1_k127_1948463_12 1380347.JNII01000008_gene4355 1.918e-49 188.0 COG2345@1|root,COG2345@2|Bacteria,2HCEF@201174|Actinobacteria,4ESVJ@85013|Frankiales 201174|Actinobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_20 GZD1_k127_1948463_16 1209984.BN978_00570 1.129e-11 73.0 COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 GZD1_k127_1948463_11 1121924.ATWH01000010_gene1014 8.679e-50 190.0 COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4FNZV@85023|Microbacteriaceae 201174|Actinobacteria H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI GZD1_k127_1948463_5 697282.Mettu_0616 7.351e-141 460.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1XEW5@135618|Methylococcales 135618|Methylococcales C Apoptosis-inducing factor, mitochondrion-associated, C-term - - - - - - - - - - - - AIF_C,Pyr_redox_2 GZD1_k127_1948463_10 861299.J421_3660 8.583e-90 309.0 2E98K@1|root,333GZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_2071680_4 861299.J421_3894 2.546e-95 320.0 COG1109@1|root,COG1109@2|Bacteria,1ZSNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV GZD1_k127_2071680_2 861299.J421_3895 1.111e-114 382.0 COG3437@1|root,COG3437@2|Bacteria,1ZSX2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HD domain - - - - - - - - - - - - HD,Response_reg GZD1_k127_2071680_0 861299.J421_3896 1.331e-159 515.0 COG0626@1|root,COG0626@2|Bacteria,1ZT9F@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP GZD1_k127_2071680_3 379066.GAU_2432 1.014e-106 355.0 COG0501@1|root,COG0501@2|Bacteria,1ZT2E@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 GZD1_k127_2071680_1 1382356.JQMP01000004_gene110 1.138e-118 396.0 COG0151@1|root,COG0151@2|Bacteria,2G5ZE@200795|Chloroflexi,27XZU@189775|Thermomicrobia 189775|Thermomicrobia F Phosphoribosylglycinamide synthetase, C domain purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N GZD1_k127_2071680_5 379066.GAU_2434 1.727e-60 221.0 COG0266@1|root,COG0266@2|Bacteria,1ZU9K@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS GZD1_k127_2071680_6 1123073.KB899241_gene1975 8.947e-51 183.0 COG0346@1|root,COG0346@2|Bacteria,1N08M@1224|Proteobacteria,1SZRB@1236|Gammaproteobacteria,1X7PV@135614|Xanthomonadales 135614|Xanthomonadales E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase GZD1_k127_2115862_3 765910.MARPU_05280 3.161e-21 102.0 COG1216@1|root,COG1216@2|Bacteria,1RKB9@1224|Proteobacteria,1SZFE@1236|Gammaproteobacteria,1X2K0@135613|Chromatiales 135613|Chromatiales S glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_2115862_0 1267534.KB906755_gene4106 3.495e-112 379.0 COG1208@1|root,COG1208@2|Bacteria,3Y2MI@57723|Acidobacteria,2JI1C@204432|Acidobacteriia 204432|Acidobacteriia JM Glucose-1-phosphate cytidylyltransferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase GZD1_k127_2115862_2 414684.RC1_3995 1.41e-68 248.0 COG2120@1|root,COG2120@2|Bacteria,1MX2V@1224|Proteobacteria,2TT5F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L GZD1_k127_2115862_1 316067.Geob_2954 2.834e-76 266.0 COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,42SZT@68525|delta/epsilon subdivisions,2WPTX@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM Transport permease protein - - - ko:K09688,ko:K09690 ko02010,map02010 M00249,M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.101,3.A.1.103 - - ABC2_membrane GZD1_k127_2115862_4 861299.J421_6071 7.286e-16 90.0 COG1134@1|root,COG1134@2|Bacteria 2|Bacteria GM teichoic acid transport - - 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 - - ABC_tran,Wzt_C GZD1_k127_212392_2 1519464.HY22_07945 8.037e-05 53.0 2ECQK@1|root,336N8@2|Bacteria,1FEWY@1090|Chlorobi 1090|Chlorobi S Capsule assembly protein Wzi - - - - - - - - - - - - Caps_assemb_Wzi GZD1_k127_212392_1 760568.Desku_3099 3.853e-05 52.0 COG5550@1|root,COG5550@2|Bacteria,1W58U@1239|Firmicutes,255IM@186801|Clostridia 186801|Clostridia O TIGRFAM clan AA aspartic protease, AF_0612 family - - - - - - - - - - - - - GZD1_k127_212392_0 1128421.JAGA01000001_gene2191 4.325e-28 115.0 COG0400@1|root,COG0400@2|Bacteria,2NRU7@2323|unclassified Bacteria 2|Bacteria S Phospholipase/Carboxylesterase - - - ko:K06999,ko:K15975 - - - - ko00000 - - - Abhydrolase_2,Glyoxalase GZD1_k127_2282054_3 379066.GAU_1405 3.412e-61 212.0 COG2204@1|root,COG2204@2|Bacteria,1ZTMH@142182|Gemmatimonadetes 142182|Gemmatimonadetes T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg GZD1_k127_2282054_0 379066.GAU_1406 5.256e-142 472.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1ZT7R@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT P2 response regulator binding domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 GZD1_k127_2282054_2 379066.GAU_1407 5.874e-70 242.0 COG1776@1|root,COG1776@2|Bacteria,1ZTIW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT CheC-like family - - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC GZD1_k127_2282054_1 379066.GAU_1408 9.985e-117 408.0 COG0457@1|root,COG0457@2|Bacteria,1ZSS6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 GZD1_k127_2282054_4 861299.J421_3061 1.934e-36 153.0 COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,TPR_16,TPR_2 GZD1_k127_2357364_3 1169143.KB911038_gene6003 1.248e-24 105.0 2AY99@1|root,31QBJ@2|Bacteria,1RI92@1224|Proteobacteria,2VSPH@28216|Betaproteobacteria,1K7SH@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_2357364_4 1123320.KB889640_gene4365 2.884e-08 66.0 COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria 201174|Actinobacteria KLT PQQ enzyme repeat - - 1.1.2.6,2.7.11.1 ko:K05889,ko:K12132 - - R03136 - ko00000,ko01000,ko01001 - - - PQQ,PQQ_2,PQQ_3,Pkinase GZD1_k127_2357364_1 75379.Tint_3118 2.049e-54 195.0 COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,2VQZE@28216|Betaproteobacteria 28216|Betaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT GZD1_k127_2357364_0 1379270.AUXF01000002_gene1600 3.086e-176 586.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - GZD1_k127_2357364_2 204669.Acid345_2239 2.381e-34 138.0 COG0251@1|root,COG0251@2|Bacteria,3Y8KT@57723|Acidobacteria 57723|Acidobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP GZD1_k127_237300_46 1303518.CCALI_01635 1.143e-08 66.0 28IEX@1|root,2Z8GX@2|Bacteria 2|Bacteria S Putative beta-barrel porin-2, OmpL-like. bbp2 - - - - - - - - - - - - BBP2 GZD1_k127_237300_5 498761.HM1_1471 1.175e-174 557.0 COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,25F02@186801|Clostridia 186801|Clostridia C Isocitrate/isopropylmalate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh GZD1_k127_237300_14 266117.Rxyl_1124 7.388e-132 447.0 COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4CPVK@84995|Rubrobacteria 84995|Rubrobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N GZD1_k127_237300_42 1379270.AUXF01000006_gene200 1.08e-16 96.0 COG4206@1|root,COG4206@2|Bacteria,1ZT1E@142182|Gemmatimonadetes 142182|Gemmatimonadetes H TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug GZD1_k127_237300_22 861299.J421_3322 1.059e-72 255.0 COG1561@1|root,COG1561@2|Bacteria,1ZT99@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N GZD1_k127_237300_30 861299.J421_3321 1.965e-49 192.0 COG0194@1|root,COG0194@2|Bacteria,1ZTV7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin GZD1_k127_237300_43 379066.GAU_1688 1.251e-14 84.0 28VAR@1|root,2ZHDJ@2|Bacteria,1ZU25@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - - - - - - - - - - - RNA_pol_Rpb6 GZD1_k127_237300_17 861299.J421_3319 2.708e-110 373.0 COG0452@1|root,COG0452@2|Bacteria,1ZV19@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein GZD1_k127_237300_31 459349.CLOAM0287 3.485e-48 196.0 COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria 2|Bacteria L Uracil DNA glycosylase superfamily ung - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG GZD1_k127_237300_7 1379270.AUXF01000006_gene205 5.075e-171 549.0 COG0305@1|root,COG0305@2|Bacteria,1ZSMZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C GZD1_k127_237300_4 861299.J421_3316 5.742e-177 567.0 COG1066@1|root,COG1066@2|Bacteria,1ZSYF@142182|Gemmatimonadetes 142182|Gemmatimonadetes O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase GZD1_k127_237300_29 861299.J421_3315 9.432e-53 194.0 COG1211@1|root,COG1211@2|Bacteria,1ZSTV@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD GZD1_k127_237300_27 861299.J421_3314 3.594e-58 209.0 COG0009@1|root,COG0009@2|Bacteria,1ZT3D@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Telomere recombination - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC GZD1_k127_237300_37 1379270.AUXF01000006_gene209 1.505e-37 150.0 COG0394@1|root,COG0394@2|Bacteria,1ZTSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Low molecular weight phosphatase family - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc GZD1_k127_237300_33 861299.J421_3312 5.521e-46 176.0 COG0169@1|root,COG0169@2|Bacteria,1ZTVG@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_dh_N GZD1_k127_237300_38 379066.GAU_1680 3.734e-37 149.0 COG1040@1|root,COG1040@2|Bacteria,1ZTS5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran GZD1_k127_237300_10 861299.J421_3310 4.566e-147 472.0 COG0057@1|root,COG0057@2|Bacteria,1ZSTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N GZD1_k127_237300_8 861299.J421_3309 5.174e-151 498.0 COG0126@1|root,COG0126@2|Bacteria,1ZT1B@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK GZD1_k127_237300_25 861299.J421_3308 1.439e-68 242.0 COG0149@1|root,COG0149@2|Bacteria,1ZSYN@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM GZD1_k127_237300_41 1379270.AUXF01000006_gene215 6.068e-22 104.0 COG1314@1|root,COG1314@2|Bacteria,1ZTZS@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Preprotein translocase SecG subunit - - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG GZD1_k127_237300_11 1379270.AUXF01000006_gene216 2.122e-143 466.0 COG0505@1|root,COG0505@2|Bacteria,1ZT0T@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Carbamoyl-phosphate synthase small chain, CPSase domain carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase GZD1_k127_237300_32 1379270.AUXF01000006_gene217 9.174e-47 170.0 COG0776@1|root,COG0776@2|Bacteria,1ZTTN@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions - - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding GZD1_k127_237300_24 329726.AM1_2056 5.913e-69 257.0 COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria 1117|Cyanobacteria S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 GZD1_k127_237300_45 713587.THITH_01495 5.042e-09 64.0 COG1977@1|root,COG1977@2|Bacteria,1NHG7@1224|Proteobacteria,1TK6F@1236|Gammaproteobacteria,1WZUM@135613|Chromatiales 135613|Chromatiales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS GZD1_k127_237300_40 292459.STH3180 7.641e-30 127.0 COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1V3V0@1239|Firmicutes,24QVX@186801|Clostridia 186801|Clostridia H Molybdopterin converting factor subunit - - 2.8.1.12 ko:K03635,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS GZD1_k127_237300_15 330214.NIDE1574 3.96e-119 397.0 COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_14,Mob_synth_C,Radical_SAM GZD1_k127_237300_20 518766.Rmar_1770 9.161e-85 294.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,1FJR1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P ABC transporter gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_237300_39 1321815.HMPREF9193_00360 1.652e-32 147.0 COG1277@1|root,COG1277@2|Bacteria,2J6H8@203691|Spirochaetes 203691|Spirochaetes S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 GZD1_k127_237300_28 518766.Rmar_1768 7.67e-55 220.0 COG3225@1|root,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,1FJTM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux GZD1_k127_237300_48 313606.M23134_01806 1.456e-05 57.0 2D6WA@1|root,32TMZ@2|Bacteria,4NU16@976|Bacteroidetes,47VUX@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 GZD1_k127_237300_9 861299.J421_3301 1.675e-150 481.0 COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N GZD1_k127_237300_16 1128421.JAGA01000003_gene2922 2.316e-111 377.0 COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria 2|Bacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 GZD1_k127_237300_0 234267.Acid_7402 0.0 1030.0 COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria 57723|Acidobacteria C Succinate dehydrogenase or fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C GZD1_k127_237300_26 1267533.KB906738_gene2431 4.075e-60 222.0 2CAZH@1|root,2Z7RU@2|Bacteria,3Y4WA@57723|Acidobacteria 57723|Acidobacteria - - - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt GZD1_k127_237300_34 411462.DORLON_02932 2.717e-43 162.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia 186801|Clostridia H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox GZD1_k127_237300_35 344747.PM8797T_29778 1.004e-41 157.0 COG0393@1|root,COG0393@2|Bacteria,2J0RP@203682|Planctomycetes 203682|Planctomycetes S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 GZD1_k127_237300_13 1009370.ALO_19477 8.854e-135 440.0 COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,4H3UJ@909932|Negativicutes 909932|Negativicutes C pyridine nucleotide-disulfide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 GZD1_k127_237300_2 1121904.ARBP01000001_gene5544 6.004e-210 680.0 COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,47JCM@768503|Cytophagia 976|Bacteroidetes O Domain of unknown function (DUF5118) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 GZD1_k127_237300_1 861299.J421_1389 1.38e-220 704.0 COG2234@1|root,COG2234@2|Bacteria,1ZSQ8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Nicastrin - - 3.4.17.21 ko:K01301 - - - - ko00000,ko01000,ko01002 - - - PA,Peptidase_M28,TFR_dimer GZD1_k127_237300_18 379066.GAU_1663 6.625e-98 322.0 COG0717@1|root,COG0717@2|Bacteria,1ZSN3@142182|Gemmatimonadetes 142182|Gemmatimonadetes F dUTPase dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase GZD1_k127_237300_36 861299.J421_3295 1.145e-37 145.0 COG0838@1|root,COG0838@2|Bacteria,1ZTKK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 GZD1_k127_237300_19 861299.J421_3294 1.112e-90 302.0 COG0377@1|root,COG0377@2|Bacteria,1ZT85@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 GZD1_k127_237300_21 379066.GAU_1660 4.405e-76 262.0 COG0852@1|root,COG0852@2|Bacteria,1ZTCJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa GZD1_k127_237300_3 861299.J421_3292 3.121e-197 622.0 COG0649@1|root,COG0649@2|Bacteria,1ZSV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa GZD1_k127_237300_23 1379270.AUXF01000006_gene233 6.821e-70 240.0 COG1905@1|root,COG1905@2|Bacteria,1ZTJ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx GZD1_k127_237300_12 264462.Bd3083 9.422e-140 457.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2MTQY@213481|Bdellovibrionales,2WJ1W@28221|Deltaproteobacteria 213481|Bdellovibrionales C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit nuoF-2 - 1.6.5.3 ko:K00334,ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB GZD1_k127_237300_6 861299.J421_3289 1.098e-173 558.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,1ZTDW@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 GZD1_k127_2379652_115 357808.RoseRS_0773 0.0001684 50.0 COG2018@1|root,COG2018@2|Bacteria,2G9R6@200795|Chloroflexi,375PX@32061|Chloroflexia 32061|Chloroflexia S PFAM Roadblock LC7 family protein - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 GZD1_k127_2379652_108 1379698.RBG1_1C00001G1744 5.433e-08 63.0 COG2018@1|root,COG2018@2|Bacteria,2NQXH@2323|unclassified Bacteria 2|Bacteria S Roadblock/LC7 domain mglB - - - - - - - - - - - Robl_LC7 GZD1_k127_2379652_47 861299.J421_3059 9.228e-83 278.0 COG1100@1|root,COG1100@2|Bacteria,1ZTK3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Small GTP-binding protein - - - ko:K06883 - - - - ko00000 - - - Arf GZD1_k127_2379652_30 1379270.AUXF01000005_gene673 1.766e-127 438.0 COG0593@1|root,COG0593@2|Bacteria,1ZUFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bacterial dnaA protein - - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA GZD1_k127_2379652_20 1379270.AUXF01000005_gene674 1.412e-137 455.0 COG0457@1|root,COG0457@2|Bacteria,1ZSPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,TPR_16,TPR_2 GZD1_k127_2379652_55 861299.J421_3062 3.388e-69 245.0 COG1352@1|root,COG1352@2|Bacteria 2|Bacteria NT protein-glutamate O-methyltransferase activity cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N GZD1_k127_2379652_84 1379270.AUXF01000005_gene675 2.316e-32 141.0 COG1871@1|root,COG1871@2|Bacteria,1ZV29@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis - - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD GZD1_k127_2379652_48 1379270.AUXF01000005_gene676 8.466e-82 285.0 COG2201@1|root,COG2201@2|Bacteria,1ZUFV@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg GZD1_k127_2379652_109 426117.M446_2054 1.251e-07 60.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2TSA3@28211|Alphaproteobacteria,1JUYQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW GZD1_k127_2379652_93 332101.JIBU02000013_gene1306 6.328e-24 112.0 COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,36ITK@31979|Clostridiaceae 186801|Clostridia NT Chemotaxis protein cheW cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW GZD1_k127_2379652_52 1379270.AUXF01000005_gene678 3.539e-74 269.0 COG0457@1|root,COG0457@2|Bacteria,1ZTK5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2 GZD1_k127_2379652_90 379066.GAU_1417 4.007e-26 121.0 2DUTE@1|root,33S5W@2|Bacteria,1ZSMI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2379652_113 545695.TREAZ_0965 6.472e-05 56.0 COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes 203691|Spirochaetes S tetratricopeptide repeat lmp1 - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8 GZD1_k127_2379652_112 637390.AFOH01000039_gene2437 3.317e-05 47.0 2EJ6D@1|root,33CXK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_2379652_44 379066.GAU_1420 4.463e-87 299.0 COG0275@1|root,COG0275@2|Bacteria,1ZT4V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 GZD1_k127_2379652_29 861299.J421_3070 1.338e-128 434.0 COG0768@1|root,COG0768@2|Bacteria,1ZSYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Penicillin binding protein transpeptidase domain - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase GZD1_k127_2379652_19 1379270.AUXF01000005_gene685 1.106e-137 477.0 COG0769@1|root,COG0769@2|Bacteria,1ZSS3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M GZD1_k127_2379652_42 1379270.AUXF01000005_gene686 3.279e-89 312.0 COG0770@1|root,COG0770@2|Bacteria,1ZT1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M GZD1_k127_2379652_32 861299.J421_3073 1.099e-126 415.0 COG0472@1|root,COG0472@2|Bacteria,1ZT4Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4 GZD1_k127_2379652_17 1379270.AUXF01000005_gene688 2.977e-142 469.0 COG0771@1|root,COG0771@2|Bacteria,1ZT38@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M GZD1_k127_2379652_62 330214.NIDE0760 2.261e-62 235.0 COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae 40117|Nitrospirae D Cell cycle protein ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE GZD1_k127_2379652_46 861299.J421_3076 6.987e-83 298.0 COG0707@1|root,COG0707@2|Bacteria,1ZSW5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 GZD1_k127_2379652_33 861299.J421_3077 7.346e-126 417.0 COG0773@1|root,COG0773@2|Bacteria,1ZSQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M GZD1_k127_2379652_91 379066.GAU_1430 6.076e-26 117.0 COG1589@1|root,COG1589@2|Bacteria,1ZTRX@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein FtsQ - - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - POTRA_1 GZD1_k127_2379652_28 861299.J421_3079 2.027e-130 433.0 COG0849@1|root,COG0849@2|Bacteria,1ZSRE@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA GZD1_k127_2379652_10 861299.J421_3080 1.757e-175 558.0 COG0206@1|root,COG0206@2|Bacteria,1ZSNH@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin GZD1_k127_2379652_65 323848.Nmul_A0554 4.654e-59 223.0 COG0739@1|root,COG3061@1|root,COG0739@2|Bacteria,COG3061@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,3726D@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 GZD1_k127_2379652_83 1442599.JAAN01000024_gene1921 7.583e-33 143.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1X3ZJ@135614|Xanthomonadales 135614|Xanthomonadales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth GZD1_k127_2379652_75 861299.J421_3082 8.77e-49 195.0 COG1572@1|root,COG1572@2|Bacteria,1ZSTW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - - GZD1_k127_2379652_58 861299.J421_3083 8.288e-68 243.0 COG0552@1|root,COG0552@2|Bacteria,1ZTBT@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N GZD1_k127_2379652_11 1379698.RBG1_1C00001G0402 1.413e-173 567.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge GZD1_k127_2379652_100 765911.Thivi_2725 2.609e-14 88.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1WWQT@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 GZD1_k127_2379652_6 379066.GAU_1447 2.604e-184 585.0 COG0017@1|root,COG0017@2|Bacteria,1ZSTX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon GZD1_k127_2379652_56 379066.GAU_1448 9.325e-69 242.0 COG1694@1|root,COG3956@2|Bacteria,1ZSZH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S MazG nucleotide pyrophosphohydrolase domain - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - MazG GZD1_k127_2379652_49 861299.J421_3093 1.223e-80 282.0 COG0787@1|root,COG0787@2|Bacteria,1ZT57@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids - - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N GZD1_k127_2379652_16 861299.J421_3094 8.34e-150 484.0 COG1015@1|root,COG1015@2|Bacteria,1ZTG3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme GZD1_k127_2379652_85 290397.Adeh_0620 4.819e-31 130.0 COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,42UZH@68525|delta/epsilon subdivisions,2WR2R@28221|Deltaproteobacteria,2YVFS@29|Myxococcales 28221|Deltaproteobacteria F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 GZD1_k127_2379652_103 861299.J421_3096 1.126e-12 80.0 2F0K0@1|root,33TNP@2|Bacteria,1ZTJU@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2379652_80 861299.J421_3097 6.204e-37 156.0 2EYUI@1|root,33S1Q@2|Bacteria,1ZTHR@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2379652_12 861299.J421_3101 1.172e-172 552.0 COG0621@1|root,COG0621@2|Bacteria,1ZT0Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 GZD1_k127_2379652_107 1235793.C809_03126 2.29e-10 68.0 2DKBS@1|root,3094C@2|Bacteria,1U4EM@1239|Firmicutes,259F4@186801|Clostridia,27S9Z@186928|unclassified Lachnospiraceae 186801|Clostridia S Late competence development protein ComFB - - - - - - - - - - - - ComFB GZD1_k127_2379652_43 379066.GAU_1455 8.314e-88 318.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1ZSMY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,Lactamase_B GZD1_k127_2379652_24 379066.GAU_1456 7.482e-133 433.0 COG0158@1|root,COG0158@2|Bacteria,1ZTAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Fructose-1-6-bisphosphatase, N-terminal domain fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase GZD1_k127_2379652_5 861299.J421_3107 3.232e-200 651.0 COG1884@1|root,COG1884@2|Bacteria,1ZT5I@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase GZD1_k127_2379652_106 861299.J421_4115 4.4e-11 76.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_2379652_98 861299.J421_3109 6.893e-19 89.0 COG2331@1|root,COG2331@2|Bacteria,1ZU2W@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Regulatory protein, FmdB family - - - - - - - - - - - - - GZD1_k127_2379652_2 1379270.AUXF01000005_gene719 1.764e-216 684.0 COG0018@1|root,COG0018@2|Bacteria,1ZT6E@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Arginyl tRNA synthetase N terminal dom argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d GZD1_k127_2379652_36 1379270.AUXF01000005_gene720 1.87e-112 374.0 COG0524@1|root,COG0524@2|Bacteria,1ZSUT@142182|Gemmatimonadetes 142182|Gemmatimonadetes G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB GZD1_k127_2379652_37 861299.J421_3112 1.38e-102 344.0 COG0150@1|root,COG0150@2|Bacteria,1ZSQJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F AIR synthase related protein, C-terminal domain purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C GZD1_k127_2379652_86 1379270.AUXF01000005_gene722 1.812e-29 136.0 2F30H@1|root,33VVT@2|Bacteria,1ZTRF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2379652_39 1379270.AUXF01000005_gene723 1.796e-98 334.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1ZSNI@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate - - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 GZD1_k127_2379652_73 861299.J421_3115 3.874e-50 185.0 COG0307@1|root,COG0307@2|Bacteria,1ZTQM@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Lumazine binding domain - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding GZD1_k127_2379652_8 861299.J421_3116 2.905e-180 582.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1ZT7J@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 GZD1_k127_2379652_77 1304874.JAFY01000007_gene2421 3.31e-44 167.0 COG0054@1|root,COG0054@2|Bacteria,3TAV8@508458|Synergistetes 508458|Synergistetes H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase GZD1_k127_2379652_92 861299.J421_3118 2.216e-25 116.0 COG0781@1|root,COG0781@2|Bacteria,1ZTRU@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB GZD1_k127_2379652_25 861299.J421_3119 1.878e-131 431.0 COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 GZD1_k127_2379652_31 379066.GAU_1477 4.786e-127 413.0 COG1493@1|root,COG1493@2|Bacteria,1ZSY3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N GZD1_k127_2379652_105 1379270.AUXF01000005_gene731 1.421e-11 71.0 COG2893@1|root,COG2893@2|Bacteria,1ZU41@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system fructose IIA component - - - ko:K02744 ko00052,ko02060,map00052,map02060 M00277,M00287 R08366,R08367 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.4,4.A.6.1.5 - - EIIA-man GZD1_k127_2379652_74 379066.GAU_1479 6.646e-49 183.0 COG3444@1|root,COG3444@2|Bacteria,1ZTQR@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose subfamily IIB component - - - ko:K19507 ko02060,map02060 M00764 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.19 - - PTSIIB_sorb GZD1_k127_2379652_96 861299.J421_3124 1.823e-20 100.0 COG3715@1|root,COG3715@2|Bacteria,1ZTVH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose-specific iic component - - - ko:K02795 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EII-Sor GZD1_k127_2379652_71 379066.GAU_1481 2.128e-51 193.0 COG3716@1|root,COG3716@2|Bacteria,1ZTJH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system mannose/fructose/sorbose family IID component - - - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EIID-AGA GZD1_k127_2379652_97 1379270.AUXF01000005_gene735 2.026e-20 103.0 COG1925@1|root,COG1925@2|Bacteria,1ZTYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS HPr component phosphorylation site - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr GZD1_k127_2379652_35 479434.Sthe_3118 2.99e-119 411.0 COG1080@1|root,COG1080@2|Bacteria,2GBRQ@200795|Chloroflexi,27YTN@189775|Thermomicrobia 189775|Thermomicrobia G PEP-utilising enzyme, N-terminal - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C GZD1_k127_2379652_13 861299.J421_3128 1.224e-169 541.0 COG0192@1|root,COG0192@2|Bacteria,1ZSZ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N GZD1_k127_2379652_9 909663.KI867150_gene944 2.349e-178 574.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MQA7@213462|Syntrophobacterales 28221|Deltaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD GZD1_k127_2379652_79 861299.J421_3129 4.69e-42 173.0 COG1259@1|root,COG1259@2|Bacteria,1ZTKW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase GZD1_k127_2379652_89 1379270.AUXF01000005_gene739 3.937e-27 124.0 COG2010@1|root,COG2010@2|Bacteria,1ZT9T@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c - - - - - - - - - - - - - GZD1_k127_2379652_76 1379270.AUXF01000005_gene740 1.379e-44 175.0 COG0614@1|root,COG0614@2|Bacteria,1ZTIM@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 GZD1_k127_2379652_57 379066.GAU_0496 8.064e-68 244.0 COG0609@1|root,COG0609@2|Bacteria,1ZTAA@142182|Gemmatimonadetes 2|Bacteria P FecCD transport family btuC - 3.6.3.34 ko:K02013,ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - FecCD GZD1_k127_2379652_69 861299.J421_3133 2.164e-53 210.0 COG1120@1|root,COG1120@2|Bacteria,1ZTB9@142182|Gemmatimonadetes 142182|Gemmatimonadetes P ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran GZD1_k127_2379652_23 861299.J421_3134 5.308e-133 446.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity btuB - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec GZD1_k127_2379652_104 1151061.CAJY01000037_gene1379 2.095e-12 79.0 COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria 201174|Actinobacteria L Involved in DNA repair and RecF pathway recombination recO GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N GZD1_k127_2379652_34 269799.Gmet_3415 3.86e-121 415.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,43TPN@69541|Desulfuromonadales 28221|Deltaproteobacteria J Elongation factor SelB winged helix 3 selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 GZD1_k127_2379652_94 1379270.AUXF01000005_gene746 4.658e-23 104.0 COG2866@1|root,COG2866@2|Bacteria,1ZTUA@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Carboxypeptidase - - - - - - - - - - - - - GZD1_k127_2379652_26 379066.GAU_2794 3.282e-131 442.0 COG1305@1|root,COG1305@2|Bacteria 2|Bacteria E Transglutaminase-like superfamily - - - - - - - - - - - - DUF3857,Transglut_core GZD1_k127_2379652_0 861299.J421_3137 0.0 1208.0 COG0542@1|root,COG0542@2|Bacteria,1ZT9Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N GZD1_k127_2379652_72 861299.J421_3139 2e-50 184.0 COG0590@1|root,COG0590@2|Bacteria,1ZTW9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33,3.8.1.5 ko:K01563,ko:K11991 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223 RC00477,RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam GZD1_k127_2379652_18 1125971.ASJB01000065_gene6243 5.539e-139 451.0 COG0520@1|root,COG0520@2|Bacteria,2GN15@201174|Actinobacteria,4E19E@85010|Pseudonocardiales 201174|Actinobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - - - - - - - - - - Aminotran_5 GZD1_k127_2379652_40 1128421.JAGA01000002_gene1518 8.631e-98 326.0 COG3483@1|root,COG3483@2|Bacteria 2|Bacteria E tryptophan 2,3-dioxygenase activity kynA GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 ko:K00453 ko00380,ko01100,map00380,map01100 M00038 R00678 RC00356 ko00000,ko00001,ko00002,ko01000 - - - Trp_dioxygenase GZD1_k127_2379652_114 1168059.KB899087_gene3133 9.747e-05 47.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae 28211|Alphaproteobacteria L Resolvase, N terminal domain - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom GZD1_k127_2379652_70 1121920.AUAU01000006_gene301 2.571e-53 193.0 2BYAB@1|root,32R2Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_2379652_1 1380394.JADL01000024_gene101 0.0 1063.0 COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2JRCI@204441|Rhodospirillales 204441|Rhodospirillales CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - FAD_binding_3,Oxidored_FMN GZD1_k127_2379652_38 670292.JH26_12415 3.049e-101 348.0 COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,1JX8D@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, middle domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GZD1_k127_2379652_45 1192034.CAP_0946 1.801e-84 293.0 COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,42QU2@68525|delta/epsilon subdivisions,2WMSF@28221|Deltaproteobacteria,2YYYW@29|Myxococcales 28221|Deltaproteobacteria I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 GZD1_k127_2379652_95 1120983.KB894572_gene3012 1.856e-21 105.0 COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2U9A9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP GZD1_k127_2379652_64 504728.K649_11975 1.033e-60 221.0 COG1028@1|root,COG1028@2|Bacteria 504728.K649_11975|- IQ oxidoreductase activity, acting on CH-OH group of donors - - - - - - - - - - - - - GZD1_k127_2379652_61 502025.Hoch_5093 1.203e-62 224.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,2Z10D@29|Myxococcales 28221|Deltaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase GZD1_k127_2379652_3 1192034.CAP_2782 6.799e-210 665.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MCF@68525|delta/epsilon subdivisions,2WJRK@28221|Deltaproteobacteria,2YYUX@29|Myxococcales 28221|Deltaproteobacteria I AMP-binding enzyme C-terminal domain bamY - 6.2.1.25 ko:K04110 ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120 - R01422 RC00004,RC00174 ko00000,ko00001,ko01000 - - iAF987.Gmet_2143 AMP-binding,AMP-binding_C GZD1_k127_2379652_51 266117.Rxyl_0619 2.169e-75 269.0 COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4CPZ9@84995|Rubrobacteria 84995|Rubrobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding - - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C GZD1_k127_2379652_54 861299.J421_3141 1.36e-71 246.0 COG2065@1|root,COG2065@2|Bacteria,1ZTHG@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran GZD1_k127_2379652_15 861299.J421_3142 4.206e-163 525.0 COG0540@1|root,COG0540@2|Bacteria,1ZSN7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N GZD1_k127_2379652_7 861299.J421_3143 2.05e-180 576.0 COG0044@1|root,COG0044@2|Bacteria,1ZT4U@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 GZD1_k127_2379652_101 861299.J421_3144 4.719e-14 83.0 COG1196@1|root,COG1196@2|Bacteria,1ZU4J@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Zinc finger domain - - - - - - - - - - - - - GZD1_k127_2379652_102 379066.GAU_1519 5.406e-13 72.0 COG0268@1|root,COG0268@2|Bacteria,1ZU6B@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p GZD1_k127_2379652_63 861299.J421_3146 2.463e-62 222.0 COG1994@1|root,COG1994@2|Bacteria,1ZTIB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 GZD1_k127_2379652_59 379066.GAU_1521 5.835e-67 244.0 COG1354@1|root,COG1354@2|Bacteria,1ZT1G@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA GZD1_k127_2379652_87 1196324.A374_03034 1.222e-28 121.0 COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,4HIQ0@91061|Bacilli 91061|Bacilli D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB GZD1_k127_2379652_68 1379270.AUXF01000005_gene777 8.565e-55 207.0 COG1187@1|root,COG1187@2|Bacteria,1ZT5B@142182|Gemmatimonadetes 142182|Gemmatimonadetes J S4 RNA-binding domain - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 GZD1_k127_2379652_21 869210.Marky_1233 3.667e-136 453.0 COG1086@1|root,COG1086@2|Bacteria 2|Bacteria GM Polysaccharide biosynthesis protein - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD GZD1_k127_2379652_27 861299.J421_3150 1.203e-130 445.0 COG0714@1|root,COG0714@2|Bacteria,1ZT94@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 GZD1_k127_2379652_53 247490.KSU1_C0858 4.316e-73 259.0 COG1721@1|root,COG1721@2|Bacteria,2IXT7@203682|Planctomycetes 203682|Planctomycetes S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 GZD1_k127_2379652_41 861299.J421_1138 1.807e-92 315.0 COG2304@1|root,COG2304@2|Bacteria,1ZSVY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF1194) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA GZD1_k127_2379652_67 379066.GAU_1528 3.353e-55 219.0 COG2304@1|root,COG2304@2|Bacteria,1ZTCZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 GZD1_k127_2379652_78 1379270.AUXF01000005_gene783 5.434e-44 185.0 COG4783@1|root,COG4783@2|Bacteria,1ZT36@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxygen tolerance - - - - - - - - - - - - BatD,SH3_4 GZD1_k127_2379652_14 861299.J421_3155 4.835e-168 546.0 COG0323@1|root,COG0323@2|Bacteria,1ZT6V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C GZD1_k127_2379652_60 861299.J421_3156 2.318e-65 236.0 COG0324@1|root,COG0324@2|Bacteria,1ZTBB@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT GZD1_k127_2379652_22 861299.J421_3157 5.336e-135 439.0 COG0438@1|root,COG0438@2|Bacteria,1ZT2W@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 GZD1_k127_2379652_99 1236689.MMALV_02570 2.558e-15 87.0 COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,3F2N5@33867|unclassified Euryarchaeota 28890|Euryarchaeota H UbiA prenyltransferase family ubiA - 2.5.1.42 ko:K17105 ko00564,map00564 - R04520 RC01171 ko00000,ko00001,ko01000 - - - UbiA GZD1_k127_2379652_81 1254432.SCE1572_15420 1.053e-34 143.0 COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2YVIU@29|Myxococcales 28221|Deltaproteobacteria H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 GZD1_k127_2379652_66 1122221.JHVI01000010_gene2527 7.397e-57 207.0 COG1521@1|root,COG1521@2|Bacteria,1WI0G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase GZD1_k127_2379652_50 1121920.AUAU01000002_gene2147 4.601e-78 282.0 COG0382@1|root,COG0382@2|Bacteria 2|Bacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.133,2.5.1.62 ko:K04040,ko:K20616 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06284,R09067,R11514,R11517 RC00020 ko00000,ko00001,ko01000,ko01006 - - - UbiA GZD1_k127_2379652_88 1301100.HG529310_gene412 5.744e-28 126.0 COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,24P2Q@186801|Clostridia,36M94@31979|Clostridiaceae 186801|Clostridia M NlpC/P60 family - - - - - - - - - - - - NLPC_P60,SH3_3 GZD1_k127_2379652_82 379066.GAU_1535 1.633e-34 134.0 COG0234@1|root,COG0234@2|Bacteria,1ZTZB@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 GZD1_k127_2379652_4 861299.J421_3164 9.567e-210 658.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 GZD1_k127_2433570_13 861299.J421_3164 1.774e-79 268.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 GZD1_k127_2433570_24 269799.Gmet_2816 1.597e-24 120.0 COG1413@1|root,COG1413@2|Bacteria,1N5TU@1224|Proteobacteria,42UDF@68525|delta/epsilon subdivisions,2WQ3K@28221|Deltaproteobacteria,43TQ4@69541|Desulfuromonadales 28221|Deltaproteobacteria C lyase activity - - - - - - - - - - - - HEAT_2 GZD1_k127_2433570_14 1379270.AUXF01000001_gene2066 1.035e-73 269.0 COG2206@1|root,COG2206@2|Bacteria 2|Bacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD GZD1_k127_2433570_12 861299.J421_4062 5.981e-80 300.0 COG0515@1|root,COG0515@2|Bacteria,1ZU8W@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_2433570_16 861299.J421_3170 5.671e-67 247.0 COG1208@1|root,COG1208@2|Bacteria,1ZSVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Sugar nucleotidyl transferase - - - - - - - - - - - - NTP_transf_4 GZD1_k127_2433570_11 861299.J421_3171 9.758e-86 301.0 COG0836@1|root,COG0836@2|Bacteria,1ZT5Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Nucleotidyl transferase - - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase GZD1_k127_2433570_29 1286631.X805_31240 1.325e-15 92.0 COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,2VM6W@28216|Betaproteobacteria,1KJE7@119065|unclassified Burkholderiales 28216|Betaproteobacteria K PFAM response regulator receiver ompR2 - - - - - - - - - - - Response_reg,Trans_reg_C GZD1_k127_2433570_22 1379270.AUXF01000005_gene807 3.944e-26 112.0 COG2018@1|root,COG2018@2|Bacteria,1ZU1J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 GZD1_k127_2433570_32 379066.GAU_1542 2.627e-07 59.0 2FES0@1|root,346R1@2|Bacteria,1ZU3X@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2433570_6 861299.J421_3175 5.413e-151 488.0 COG0172@1|root,COG0172@2|Bacteria,1ZT0V@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b GZD1_k127_2433570_15 379066.GAU_1544 1.663e-71 257.0 COG5000@1|root,COG5000@2|Bacteria,1ZSKZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c GZD1_k127_2433570_1 1379270.AUXF01000005_gene811 5.718e-215 691.0 COG0210@1|root,COG0210@2|Bacteria,1ZTD5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C GZD1_k127_2433570_31 565045.NOR51B_2341 4.858e-09 67.0 COG0721@1|root,COG0721@2|Bacteria 2|Bacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - iAF987.Gmet_0076 Glu-tRNAGln GZD1_k127_2433570_5 1379270.AUXF01000005_gene813 1.057e-160 518.0 COG0154@1|root,COG0154@2|Bacteria,1ZT24@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase GZD1_k127_2433570_8 572477.Alvin_2789 5.939e-145 484.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey GZD1_k127_2433570_9 861299.J421_3181 3.477e-105 357.0 28Q1P@1|root,2ZB8E@2|Bacteria,1ZSPA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Zinc dependent phospholipase C - - - - - - - - - - - - Zn_dep_PLPC GZD1_k127_2433570_28 404589.Anae109_3866 5.066e-16 91.0 COG0025@1|root,COG0025@2|Bacteria,1N7PG@1224|Proteobacteria,42V45@68525|delta/epsilon subdivisions,2WRJ6@28221|Deltaproteobacteria 28221|Deltaproteobacteria P NhaP-type Na H and K H - - - - - - - - - - - - - GZD1_k127_2433570_4 861299.J421_3183 8.788e-181 575.0 COG0766@1|root,COG0766@2|Bacteria,1ZSZ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase GZD1_k127_2433570_21 861299.J421_3184 1.091e-36 154.0 COG1496@1|root,COG1496@2|Bacteria,1ZTTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Multi-copper polyphenol oxidoreductase laccase - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 GZD1_k127_2433570_26 379066.GAU_1553 1.992e-24 109.0 COG0779@1|root,COG0779@2|Bacteria,1ZTX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C GZD1_k127_2433570_3 379066.GAU_1554 1.757e-196 621.0 COG0195@1|root,COG0195@2|Bacteria,1ZSNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N GZD1_k127_2433570_30 861299.J421_3187 1.31e-12 75.0 COG1358@1|root,COG1358@2|Bacteria,1ZU1M@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - - - - - - - - - - Ribosomal_L7Ae GZD1_k127_2433570_0 861299.J421_3188 1.236e-293 926.0 COG0532@1|root,COG0532@2|Bacteria,1ZT5H@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N GZD1_k127_2433570_27 234267.Acid_5182 4.341e-21 95.0 COG1550@1|root,COG1550@2|Bacteria,3Y5B8@57723|Acidobacteria 57723|Acidobacteria S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 GZD1_k127_2433570_25 1121428.DESHY_80090___1 1.968e-24 115.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,262H0@186807|Peptococcaceae 186801|Clostridia J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA GZD1_k127_2433570_19 1128421.JAGA01000003_gene3155 3.01e-50 195.0 COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria 2|Bacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C,TruB_C_2,TruB_N GZD1_k127_2433570_10 861299.J421_3191 4.535e-90 310.0 COG0196@1|root,COG0196@2|Bacteria,1ZSM5@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Riboflavin kinase - - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase GZD1_k127_2433570_7 861299.J421_3192 3.016e-147 484.0 COG0342@1|root,COG0342@2|Bacteria,1ZTBW@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG GZD1_k127_2433570_18 1123229.AUBC01000017_gene3849 6.378e-56 211.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,3JUBX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03072,ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG GZD1_k127_2433570_17 1238182.C882_3883 6.95e-63 226.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,2JR2C@204441|Rhodospirillales 204441|Rhodospirillales L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase GZD1_k127_2433570_2 1304866.K413DRAFT_3759 1.778e-214 688.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,36EI0@31979|Clostridiaceae 186801|Clostridia F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS GZD1_k127_2433570_20 1125863.JAFN01000001_gene1797 2.372e-40 152.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria 28221|Deltaproteobacteria J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP GZD1_k127_2433570_23 861299.J421_0554 4.523e-26 123.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0554|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_2433636_4 1120953.AUBH01000011_gene456 1.241e-71 246.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,1RP38@1236|Gammaproteobacteria,465NW@72275|Alteromonadaceae 1236|Gammaproteobacteria M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ GZD1_k127_2433636_0 861299.J421_6141 5.303e-149 501.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_6141|- V efflux transmembrane transporter activity - - - - - - - - - - - - - GZD1_k127_2433636_5 1267534.KB906754_gene3648 7.448e-58 212.0 298RU@1|root,2ZVW4@2|Bacteria,3Y4I6@57723|Acidobacteria,2JMQI@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - GZD1_k127_2433636_6 1123073.KB899241_gene3261 8.018e-56 205.0 COG0823@1|root,COG0823@2|Bacteria,1N4BQ@1224|Proteobacteria,1T0KT@1236|Gammaproteobacteria 1236|Gammaproteobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 GZD1_k127_2433636_1 1379270.AUXF01000001_gene2235 1.323e-117 397.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - GerE,Response_reg,TPR_19 GZD1_k127_2433636_9 1287276.X752_20015 1.739e-34 139.0 COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria,43QCN@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Cupin_7,DUF4437 GZD1_k127_2433636_2 247634.GPB2148_1480 8.042e-98 337.0 COG1468@1|root,COG1468@2|Bacteria,1QW0M@1224|Proteobacteria,1RS6B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 GZD1_k127_2433636_8 861299.J421_3625 4.886e-43 161.0 COG3118@1|root,COG3118@2|Bacteria,1ZV4B@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Thioredoxin-like domain - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin GZD1_k127_2433636_10 234267.Acid_4684 7.691e-31 133.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin GZD1_k127_2433636_7 1304872.JAGC01000009_gene1213 7.781e-49 179.0 COG0454@1|root,COG0456@2|Bacteria,1Q1ZZ@1224|Proteobacteria,42USA@68525|delta/epsilon subdivisions,2WQ2Q@28221|Deltaproteobacteria,2MB9I@213115|Desulfovibrionales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 GZD1_k127_2433636_3 379066.GAU_3792 4.329e-81 276.0 COG5587@1|root,COG5587@2|Bacteria,1ZTH8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 GZD1_k127_2433636_11 1173022.Cri9333_2145 8.099e-07 59.0 COG1943@1|root,COG1943@2|Bacteria,1G5SV@1117|Cyanobacteria,1HBAQ@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp GZD1_k127_2481998_4 543632.JOJL01000027_gene2676 4.991e-53 207.0 COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,2GZ7K@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,Response_reg GZD1_k127_2481998_3 1349767.GJA_455 3.592e-63 223.0 COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2VK6A@28216|Betaproteobacteria,4743P@75682|Oxalobacteraceae 28216|Betaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K09017 - - - - ko00000,ko03000 - - - TetR_C_11,TetR_N GZD1_k127_2481998_2 861299.J421_2437 2.268e-68 248.0 COG1538@1|root,COG1538@2|Bacteria,1ZSUV@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP GZD1_k127_2481998_1 861299.J421_2436 1.07e-82 288.0 COG1566@1|root,COG1566@2|Bacteria,1ZT4J@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Biotin-lipoyl like - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3 GZD1_k127_2481998_0 1379270.AUXF01000002_gene1851 2.382e-100 333.0 COG0477@1|root,COG0477@2|Bacteria,1ZT3N@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sugar (and other) transporter - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 GZD1_k127_2490999_2 204669.Acid345_3014 3.833e-186 618.0 COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg GZD1_k127_2490999_26 583355.Caka_1913 3.418e-54 196.0 COG2199@1|root,COG3706@2|Bacteria,46ST0@74201|Verrucomicrobia,3K80V@414999|Opitutae 414999|Opitutae T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg GZD1_k127_2490999_23 861299.J421_3797 1.919e-60 222.0 COG0470@1|root,COG0470@2|Bacteria,1ZT21@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 GZD1_k127_2490999_28 861299.J421_3798 1.429e-53 192.0 COG0315@1|root,COG0315@2|Bacteria,1ZU6G@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC GZD1_k127_2490999_33 861299.J421_3799 5.415e-30 128.0 COG0741@1|root,COG0741@2|Bacteria,1ZTV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase SLT domain - - - - - - - - - - - - SLT GZD1_k127_2490999_20 379066.GAU_2228 8.325e-75 273.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1ZSX0@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase SLT domain - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT GZD1_k127_2490999_43 861299.J421_3801 4.143e-11 70.0 2960H@1|root,2ZTB5@2|Bacteria,1ZU7H@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2490999_12 592015.HMPREF1705_02114 6.381e-96 322.0 COG0115@1|root,COG0115@2|Bacteria,3T9VI@508458|Synergistetes 508458|Synergistetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 GZD1_k127_2490999_39 1379270.AUXF01000002_gene1781 2.659e-17 88.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding - - - - - - - - - - - - PBP_like_2 GZD1_k127_2490999_7 861299.J421_0829 1.517e-117 394.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - GAF,HTH_8,Sigma54_activat GZD1_k127_2490999_35 861299.J421_0830 5.243e-28 126.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0830|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_2490999_5 204669.Acid345_0476 8.683e-129 425.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,3Y2NX@57723|Acidobacteria 57723|Acidobacteria O L-lysine 6-monooxygenase (NADPH-requiring) - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_3 GZD1_k127_2490999_34 204669.Acid345_0468 7.061e-30 132.0 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity - - - - - - - - - - - - FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding GZD1_k127_2490999_10 404589.Anae109_2645 6.897e-108 381.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,4397N@68525|delta/epsilon subdivisions,2X4EI@28221|Deltaproteobacteria,2YYVA@29|Myxococcales 28221|Deltaproteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrome_C7 GZD1_k127_2490999_9 204669.Acid345_0471 1.696e-108 381.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - - GZD1_k127_2490999_38 880073.Calab_3331 2.251e-20 106.0 2919D@1|root,2ZNWG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_2490999_22 861299.J421_0411 1.755e-65 248.0 COG0583@1|root,COG0583@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - - - - - - - - - - HTH_1,LysR_substrate GZD1_k127_2490999_44 1234664.AMRO01000072_gene3552 1.424e-07 65.0 COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,4HB40@91061|Bacilli,1WE8H@129337|Geobacillus 91061|Bacilli NT CheC-like family cheC GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896,GO:0050918 - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC,CheX GZD1_k127_2490999_8 316067.Geob_1847 1.197e-108 374.0 COG3437@1|root,COG3852@1|root,COG4191@1|root,COG3437@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X7PG@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg GZD1_k127_2490999_13 861299.J421_0728 4.696e-93 314.0 COG3315@1|root,COG3315@2|Bacteria 2|Bacteria Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - - - - - - - - - - LCM GZD1_k127_2490999_29 861299.J421_5702 2.337e-53 201.0 COG4454@1|root,COG4454@2|Bacteria,1ZTKN@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2490999_24 479434.Sthe_0472 2.351e-57 209.0 COG0164@1|root,COG0164@2|Bacteria,2G6KR@200795|Chloroflexi,27YAF@189775|Thermomicrobia 189775|Thermomicrobia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII GZD1_k127_2490999_32 1382304.JNIL01000001_gene626 6.259e-41 158.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,278F5@186823|Alicyclobacillaceae 91061|Bacilli J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 GZD1_k127_2490999_18 861299.J421_3824 4.279e-84 284.0 COG0336@1|root,COG0336@2|Bacteria,1ZT8K@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT GZD1_k127_2490999_45 935839.JAGJ01000007_gene3094 1.075e-06 57.0 COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4F4EF@85017|Promicromonosporaceae 201174|Actinobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0008150,GO:0040007 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM GZD1_k127_2490999_37 857293.CAAU_0186 4.162e-24 111.0 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,36KP2@31979|Clostridiaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 GZD1_k127_2490999_4 1430331.EP10_16840 3.533e-130 428.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H9T4@91061|Bacilli,1WFBE@129337|Geobacillus 91061|Bacilli U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB GZD1_k127_2490999_41 1118054.CAGW01000061_gene2478 1.438e-16 93.0 COG4399@1|root,COG4399@2|Bacteria,1TQDH@1239|Firmicutes,4HA30@91061|Bacilli,26SSH@186822|Paenibacillaceae 91061|Bacilli S Protein of unknown function (DUF445) yheB - - - - - - - - - - - DUF445 GZD1_k127_2490999_27 379066.GAU_2350 4.611e-54 212.0 COG2856@1|root,COG2856@2|Bacteria,1ZSXU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zn peptidase - - - - - - - - - - - - - GZD1_k127_2490999_11 861299.J421_3831 2.331e-105 354.0 COG0542@1|root,COG0542@2|Bacteria 2|Bacteria O response to heat - - - ko:K03695,ko:K03696,ko:K03697,ko:K03798 ko01100,ko04213,map01100,map04213 M00742 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,Peptidase_M41 GZD1_k127_2490999_25 379066.GAU_2351 5.926e-56 206.0 COG1989@1|root,COG1989@2|Bacteria,1ZT9K@142182|Gemmatimonadetes 142182|Gemmatimonadetes NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 GZD1_k127_2490999_30 861299.J421_3833 3.775e-50 196.0 COG0566@1|root,COG0566@2|Bacteria,1ZTVA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNA 2'-O ribose methyltransferase substrate binding - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind GZD1_k127_2490999_19 1449080.JQMV01000003_gene1071 4.84e-75 261.0 COG0351@1|root,COG0351@2|Bacteria,1WIN0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin GZD1_k127_2490999_17 1379270.AUXF01000003_gene3573 5.107e-85 293.0 COG0005@1|root,COG0005@2|Bacteria,1ZTGZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate - - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 GZD1_k127_2490999_3 234267.Acid_5232 2.364e-148 488.0 COG1972@1|root,COG1972@2|Bacteria,3Y2KI@57723|Acidobacteria 57723|Acidobacteria F PFAM Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N GZD1_k127_2490999_16 861299.J421_3836 8.264e-90 321.0 COG1816@1|root,COG1816@2|Bacteria,1ZSQ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Adenosine/AMP deaminase - - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase GZD1_k127_2490999_1 379066.GAU_2357 1.142e-203 671.0 COG0737@1|root,COG0737@2|Bacteria,1ZTEA@142182|Gemmatimonadetes 142182|Gemmatimonadetes F 5'-nucleotidase, C-terminal domain - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos GZD1_k127_2490999_14 861299.J421_3840 3.93e-92 308.0 COG0745@1|root,COG0745@2|Bacteria,1ZTC6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C GZD1_k127_2490999_15 379066.GAU_2360 4.338e-90 321.0 COG5002@1|root,COG5002@2|Bacteria,1ZT2H@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA GZD1_k127_2490999_21 1087481.AGFX01000010_gene4301 3.129e-69 249.0 COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,4HA41@91061|Bacilli,26R6M@186822|Paenibacillaceae 91061|Bacilli M glycosyl transferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 GZD1_k127_2490999_40 670487.Ocepr_0114 8.305e-17 94.0 COG1524@1|root,COG1524@2|Bacteria,1WMNH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Sulfatase - - - - - - - - - - - - Phosphodiest GZD1_k127_2490999_42 1379270.AUXF01000004_gene3194 1.565e-15 82.0 COG0671@1|root,COG0671@2|Bacteria,1ZUX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes I PAP2 superfamily - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 GZD1_k127_2490999_6 243231.GSU2559 9.301e-124 415.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,43UE3@69541|Desulfuromonadales 28221|Deltaproteobacteria FP metal-dependent phosphohydrolase, HD sub domain gppA-2 - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA GZD1_k127_2490999_0 378806.STAUR_6910 8.125e-223 714.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,2YUAP@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N GZD1_k127_2490999_31 519989.ECTPHS_11747 2.925e-43 171.0 COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria,1SVFR@1236|Gammaproteobacteria,1X1YH@135613|Chromatiales 135613|Chromatiales S CHAD - - - - - - - - - - - - CHAD GZD1_k127_2495745_0 518766.Rmar_1095 3.731e-66 252.0 COG1629@1|root,COG4771@2|Bacteria,4NFJJ@976|Bacteroidetes,1FJXK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor bfeA - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_2495745_8 399795.CtesDRAFT_PD1596 9.202e-12 73.0 2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,4ACJ0@80864|Comamonadaceae 28216|Betaproteobacteria M Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 GZD1_k127_2495745_10 861299.J421_1305 7.547e-07 59.0 28YSJ@1|root,343H2@2|Bacteria,1ZU2N@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2495745_7 330214.NIDE1608 1.566e-16 88.0 COG0296@1|root,COG0296@2|Bacteria 2|Bacteria G 1,4-alpha-glucan branching enzyme activity - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - AMPK1_CBM,Alpha-amylase,Alpha-amylase_C,CBM_48 GZD1_k127_2495745_6 861299.J421_2380 2.193e-24 109.0 COG1595@1|root,COG1595@2|Bacteria,1ZSWF@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_2495745_9 861299.J421_1304 4.48e-09 68.0 2C9AW@1|root,2ZUFM@2|Bacteria,1ZUCC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2495745_1 861299.J421_0662 8.248e-57 200.0 COG2030@1|root,COG2030@2|Bacteria 2|Bacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas GZD1_k127_2495745_3 929703.KE386491_gene3506 2.684e-48 185.0 2CEJ5@1|root,2Z7RK@2|Bacteria,4NGWQ@976|Bacteroidetes,47N0C@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - Phenol_MetA_deg GZD1_k127_2495745_5 1267533.KB906736_gene1027 5.943e-28 131.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y44T@57723|Acidobacteria,2JMDM@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C GZD1_k127_2495745_2 861299.J421_6034 9.784e-49 197.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C GZD1_k127_2495745_4 1313301.AUGC01000016_gene871 2.446e-39 165.0 COG0823@1|root,COG2885@1|root,COG0823@2|Bacteria,COG2885@2|Bacteria,4NHCE@976|Bacteroidetes 976|Bacteroidetes MU OmpA family - - - - - - - - - - - - OmpA,PD40,TPR_11,TPR_16 GZD1_k127_2509607_15 518766.Rmar_0958 5.3e-82 278.0 COG3828@1|root,COG3828@2|Bacteria,4PND4@976|Bacteroidetes 976|Bacteroidetes S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 GZD1_k127_2509607_12 861299.J421_3916 1.269e-95 323.0 COG0618@1|root,COG0618@2|Bacteria,1ZSS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 GZD1_k127_2509607_6 886293.Sinac_4878 1.032e-170 549.0 COG0531@1|root,COG0531@2|Bacteria,2IXT5@203682|Planctomycetes 203682|Planctomycetes E PFAM Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GZD1_k127_2509607_13 1411123.JQNH01000001_gene3830 5.234e-93 315.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 GZD1_k127_2509607_1 379066.GAU_2451 2.698e-243 758.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1ZTG9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH GZD1_k127_2509607_29 861299.J421_3920 3.526e-17 93.0 2F9BP@1|root,341NP@2|Bacteria,1ZTX1@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2509607_4 861299.J421_3922 6.941e-206 652.0 COG0696@1|root,COG0696@2|Bacteria,1ZSWH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N GZD1_k127_2509607_30 379066.GAU_2459 4.466e-16 92.0 2F8UF@1|root,3416F@2|Bacteria,1ZTX9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2509607_27 929713.NIASO_19245 4.708e-23 112.0 COG0720@1|root,COG0720@2|Bacteria,4NNY0@976|Bacteroidetes,1ISCG@117747|Sphingobacteriia 976|Bacteroidetes H 6-pyruvoyl tetrahydrobiopterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS GZD1_k127_2509607_25 1121472.AQWN01000002_gene2295 9.531e-36 142.0 COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24N7A@186801|Clostridia,262C9@186807|Peptococcaceae 186801|Clostridia S PFAM CoA-binding domain protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 GZD1_k127_2509607_26 861299.J421_5587 3.543e-34 142.0 COG0746@1|root,COG0746@2|Bacteria,1ZU64@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 GZD1_k127_2509607_28 1485544.JQKP01000005_gene338 3.693e-22 110.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,44WF6@713636|Nitrosomonadales 28216|Betaproteobacteria H Molybdopterin guanine dinucleotide synthesis protein B mobB - - ko:K03753 - - - - ko00000 - - - MobB GZD1_k127_2509607_11 861299.J421_3927 3.762e-97 332.0 COG0303@1|root,COG0303@2|Bacteria,1ZT4D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N GZD1_k127_2509607_22 204669.Acid345_0603 8.366e-49 196.0 COG2095@1|root,COG2095@2|Bacteria,3Y429@57723|Acidobacteria,2JI6F@204432|Acidobacteriia 204432|Acidobacteriia U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC GZD1_k127_2509607_17 861299.J421_2036 1.396e-78 286.0 2EXQQ@1|root,33R07@2|Bacteria,1ZUK8@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2509607_23 379066.GAU_0431 2.752e-39 164.0 COG5276@1|root,COG5276@2|Bacteria,1ZUNS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LVIVD repeat - - - - - - - - - - - - LVIVD GZD1_k127_2509607_3 1379698.RBG1_1C00001G0629 5.877e-208 672.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor etf GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 GZD1_k127_2509607_14 1379270.AUXF01000003_gene3457 1.296e-84 302.0 COG2025@1|root,COG2025@2|Bacteria,1ZTDU@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Electron transfer flavoprotein domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha GZD1_k127_2509607_16 1379270.AUXF01000003_gene3456 7.686e-79 270.0 COG2086@1|root,COG2086@2|Bacteria,1ZT51@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF GZD1_k127_2509607_5 861299.J421_3934 1.911e-196 618.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GZD1_k127_2509607_21 861299.J421_3936 3.804e-62 228.0 COG1409@1|root,COG1409@2|Bacteria,1ZTQ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos GZD1_k127_2509607_24 1122236.KB905141_gene949 2.486e-38 162.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria,2KKQV@206350|Nitrosomonadales 206350|Nitrosomonadales S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 GZD1_k127_2509607_8 189753.AXAS01000013_gene5923 1.44e-141 457.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3JYM8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh GZD1_k127_2509607_20 1379698.RBG1_1C00001G0906 3.326e-62 224.0 COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GZD1_k127_2509607_0 997346.HMPREF9374_0159 1.493e-250 793.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,4H9SU@91061|Bacilli,27BJQ@186824|Thermoactinomycetaceae 91061|Bacilli T 5TM C-terminal transporter carbon starvation CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM GZD1_k127_2509607_31 379066.GAU_2479 8.741e-06 49.0 COG2879@1|root,COG2879@2|Bacteria,1ZU6T@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Selenoprotein, putative - - - - - - - - - - - - Sel_put GZD1_k127_2509607_2 279714.FuraDRAFT_0071 1.637e-231 733.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KPED@206351|Neisseriales 206351|Neisseriales P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans GZD1_k127_2509607_19 861299.J421_3940 9.806e-70 262.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1,Sugar_tr GZD1_k127_2509607_18 457570.Nther_2188 1.331e-76 287.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 GZD1_k127_2509607_9 1379698.RBG1_1C00001G0513 2.082e-140 456.0 COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA3 - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like GZD1_k127_2509607_10 861299.J421_3941 1.552e-101 344.0 COG0624@1|root,COG0624@2|Bacteria,1ZTIX@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 GZD1_k127_2509607_7 1379270.AUXF01000002_gene1851 1.82e-166 535.0 COG0477@1|root,COG0477@2|Bacteria,1ZT3N@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sugar (and other) transporter - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 GZD1_k127_2524308_2 861299.J421_2924 1.115e-08 66.0 COG4932@1|root,COG4932@2|Bacteria,1ZUFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M domain protein - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - - GZD1_k127_2524308_1 379066.GAU_0239 5.086e-98 335.0 2E0UX@1|root,32WC9@2|Bacteria,1ZUE1@142182|Gemmatimonadetes 2|Bacteria - - - - - - - - - - - - - - Phenol_MetA_deg GZD1_k127_2524308_0 243231.GSU0489 2.83e-177 565.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,43SC2@69541|Desulfuromonadales 28221|Deltaproteobacteria O PFAM magnesium chelatase ChlI subunit comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C GZD1_k127_2614504_12 861299.J421_3391 5.497e-99 334.0 COG0124@1|root,COG0124@2|Bacteria,1ZSXX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_His GZD1_k127_2614504_3 861299.J421_3390 4.216e-197 637.0 COG0442@1|root,COG0442@2|Bacteria,1ZT48@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b GZD1_k127_2614504_11 161156.JQKW01000007_gene859 2.82e-112 382.0 COG0019@1|root,COG0019@2|Bacteria,2GHHY@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC GZD1_k127_2614504_2 379066.GAU_1750 4.147e-226 714.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1ZSMF@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase GZD1_k127_2614504_21 379066.GAU_1741 4.909e-71 242.0 COG1762@1|root,COG1762@2|Bacteria,1ZTIY@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 GZD1_k127_2614504_9 861299.J421_3385 1.187e-123 405.0 COG0042@1|root,COG0042@2|Bacteria,1ZSQC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus GZD1_k127_2614504_24 871968.DESME_09200 2.699e-64 239.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,260TX@186807|Peptococcaceae 186801|Clostridia S (AIR) carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC GZD1_k127_2614504_29 596154.Alide2_4695 1.674e-30 139.0 COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,2VNH2@28216|Betaproteobacteria,4ACVV@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,MASE2 GZD1_k127_2614504_32 1243664.CAVL020000008_gene4380 2.284e-12 76.0 2EJ6V@1|root,33CY2@2|Bacteria,1VPDN@1239|Firmicutes,4HS8D@91061|Bacilli,1ZIQW@1386|Bacillus 91061|Bacilli S Yip1 domain yknW - - - - - - - - - - - Yip1 GZD1_k127_2614504_0 861299.J421_3382 0.0 1053.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1ZU89@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N GZD1_k127_2614504_5 1379270.AUXF01000006_gene152 1.351e-173 558.0 COG0034@1|root,COG0034@2|Bacteria,1ZTD7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6 GZD1_k127_2614504_1 861299.J421_3380 2.723e-274 874.0 COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C GZD1_k127_2614504_18 266117.Rxyl_0995 1.056e-79 278.0 COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4CPW1@84995|Rubrobacteria 84995|Rubrobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 GZD1_k127_2614504_31 861299.J421_3377 1.162e-21 108.0 COG1828@1|root,COG1828@2|Bacteria,1ZU3W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS GZD1_k127_2614504_22 379066.GAU_1734 3.699e-69 246.0 COG1183@1|root,COG1183@2|Bacteria,1ZTJP@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf GZD1_k127_2614504_28 156889.Mmc1_0901 5.07e-36 151.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase GZD1_k127_2614504_10 652103.Rpdx1_0639 1.654e-117 394.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TS0T@28211|Alphaproteobacteria,3JRJ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F phosphoribosylaminoimidazole-succinocarboxamide synthase purC2 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt GZD1_k127_2614504_6 861299.J421_3373 7.771e-170 559.0 COG0015@1|root,COG0015@2|Bacteria,1ZSVW@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Adenylosuccinate lyase C-terminus - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 GZD1_k127_2614504_17 653733.Selin_0820 4.613e-82 278.0 COG0176@1|root,COG0176@2|Bacteria 2|Bacteria G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA GZD1_k127_2614504_16 1379270.AUXF01000006_gene161 1.477e-83 286.0 COG0101@1|root,COG0101@2|Bacteria,1ZSRZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 GZD1_k127_2614504_15 861299.J421_3367 2.681e-86 309.0 COG0547@1|root,COG0547@2|Bacteria,1ZTDS@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 GZD1_k127_2614504_20 379066.GAU_1726 9.982e-75 261.0 COG1974@1|root,COG1974@2|Bacteria,1ZSSM@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 GZD1_k127_2614504_25 1379270.AUXF01000006_gene165 6.639e-59 214.0 COG0134@1|root,COG0134@2|Bacteria,1ZTMA@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Indole-3-glycerol phosphate synthase - - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS GZD1_k127_2614504_4 379066.GAU_1723 1.21e-174 559.0 COG0133@1|root,COG0133@2|Bacteria,1ZSUM@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP GZD1_k127_2614504_13 1379270.AUXF01000006_gene168 2.236e-98 342.0 COG1413@1|root,COG1413@2|Bacteria,1ZUI4@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 GZD1_k127_2614504_7 379066.GAU_1721 3.118e-143 475.0 COG2206@1|root,COG2206@2|Bacteria,1ZUTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD GZD1_k127_2614504_23 861299.J421_3362 4.217e-66 238.0 COG0159@1|root,COG0159@2|Bacteria,1ZSYU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA GZD1_k127_2614504_30 292459.STH1082 1.244e-27 130.0 COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,sCache_3_3 GZD1_k127_2614504_26 861299.J421_3360 1.887e-41 156.0 COG0801@1|root,COG1713@1|root,COG0801@2|Bacteria,COG1713@2|Bacteria,1ZTTH@142182|Gemmatimonadetes 142182|Gemmatimonadetes H HD superfamily hydrolase involved in NAD metabolism - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - - GZD1_k127_2614504_14 653733.Selin_2222 6.222e-93 312.0 COG0413@1|root,COG0413@2|Bacteria 2|Bacteria H 3-methyl-2-oxobutanoate hydroxymethyltransferase activity panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf GZD1_k127_2614504_19 471852.Tcur_4487 8.411e-79 272.0 COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4EG66@85012|Streptosporangiales 201174|Actinobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase GZD1_k127_2614504_27 1379270.AUXF01000006_gene171 1.324e-38 150.0 COG1713@1|root,COG1713@2|Bacteria,1ZTTH@142182|Gemmatimonadetes 142182|Gemmatimonadetes H HD superfamily hydrolase involved in NAD metabolism - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - - GZD1_k127_2614504_8 1379270.AUXF01000006_gene172 5.613e-124 413.0 COG0820@1|root,COG0820@2|Bacteria,1ZTAJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM GZD1_k127_2692185_23 1379270.AUXF01000003_gene3669 4.961e-06 57.0 2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_2692185_7 243231.GSU2041 2.507e-135 444.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43U83@69541|Desulfuromonadales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_2692185_12 379066.GAU_2522 5.847e-64 234.0 COG4191@1|root,COG4191@2|Bacteria,1ZSSB@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA GZD1_k127_2692185_19 861299.J421_3986 3.347e-23 105.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE - - ko:K02456,ko:K02650,ko:K02655 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - ComP_DUS,N_methyl GZD1_k127_2692185_17 81824.XP_001743831.1 2.206e-30 137.0 COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta 33154|Opisthokonta C positive regulation of proteasomal protein catabolic process - - - - - - - - - - - - DUF1736 GZD1_k127_2692185_18 234267.Acid_6192 8.766e-27 126.0 COG0457@1|root,COG0457@2|Bacteria,3Y77J@57723|Acidobacteria 57723|Acidobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - DUF1736,TPR_11,TPR_16 GZD1_k127_2692185_24 575540.Isop_3054 8.423e-05 55.0 COG1807@1|root,COG1807@2|Bacteria,2J1H1@203682|Planctomycetes 203682|Planctomycetes M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 GZD1_k127_2692185_11 1307759.JOMJ01000004_gene2869 1.316e-77 277.0 COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2M9BR@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,GtrA GZD1_k127_2692185_14 234267.Acid_4352 2.967e-49 186.0 COG1215@1|root,COG2227@1|root,COG1215@2|Bacteria,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - ko:K07011,ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2,Methyltransf_23 GZD1_k127_2692185_1 861299.J421_3987 2.183e-200 640.0 COG2204@1|root,COG2204@2|Bacteria,1ZSRQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_2692185_8 379066.GAU_2526 1.135e-119 404.0 COG3852@1|root,COG3852@2|Bacteria,1ZSYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA GZD1_k127_2692185_5 861299.J421_4156 4.329e-174 554.0 COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Type II secretion system (T2SS), protein F - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF GZD1_k127_2692185_3 861299.J421_4157 3.023e-187 591.0 COG2805@1|root,COG2805@2|Bacteria,1ZSQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE GZD1_k127_2692185_2 1192034.CAP_0108 1.365e-190 611.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YTYC@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding GZD1_k127_2692185_20 1479623.JHEL01000015_gene485 1.707e-16 84.0 COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4FPAM@85023|Microbacteriaceae 201174|Actinobacteria L SLBB domain comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB GZD1_k127_2692185_13 596327.PORUE0001_1737 2.109e-63 229.0 COG2234@1|root,COG2234@2|Bacteria,4NG2A@976|Bacteroidetes,2FN1C@200643|Bacteroidia,22X6Y@171551|Porphyromonadaceae 976|Bacteroidetes S Glutamine cyclotransferase - - - - - - - - - - - - Peptidase_M28 GZD1_k127_2692185_0 1379270.AUXF01000001_gene2822 1.139e-270 921.0 COG4797@1|root,COG4797@2|Bacteria 2|Bacteria - - - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 - - - - - - - - - - Glyco_transf_41,MethyTransf_Reg,Methyltransf_12,Methyltransf_25,Methyltransf_31 GZD1_k127_2692185_9 861299.J421_4162 1.139e-97 348.0 COG0795@1|root,COG0795@2|Bacteria,1ZTJR@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Predicted permease YjgP/YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ GZD1_k127_2692185_10 861299.J421_4163 2.068e-93 323.0 COG0795@1|root,COG0795@2|Bacteria,1ZSNM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Predicted permease YjgP/YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ GZD1_k127_2692185_4 518766.Rmar_0330 2.785e-179 600.0 COG1629@1|root,COG4771@2|Bacteria,4NF66@976|Bacteroidetes,1FIX1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P CarboxypepD_reg-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec GZD1_k127_2692185_6 391625.PPSIR1_22374 1.18e-150 491.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,42MGQ@68525|delta/epsilon subdivisions,2WSUN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM amino acid permease-associated region - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GZD1_k127_2692185_15 861299.J421_4171 1.401e-37 153.0 COG1612@1|root,COG1612@2|Bacteria,1ZURE@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome oxidase assembly protein - - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA GZD1_k127_2692185_16 945713.IALB_0488 2.085e-34 147.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - UPF0164 GZD1_k127_2692185_22 518766.Rmar_0356 1.063e-11 79.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family ebh - - - - - - - - - - - DUF1611,Inhibitor_I9,Peptidase_S8,SLH GZD1_k127_2692185_25 987059.RBXJA2T_09317 0.0001929 53.0 COG2202@1|root,COG3852@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1KNP0@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - DUF3365,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg GZD1_k127_2692185_26 945713.IALB_1169 0.0005356 50.0 COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_2692186_25 945713.IALB_1169 0.0005356 50.0 COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_2692186_8 1144275.COCOR_02903 1.175e-128 449.0 COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,42SM7@68525|delta/epsilon subdivisions,2WP5E@28221|Deltaproteobacteria,2YYGZ@29|Myxococcales 28221|Deltaproteobacteria G Converts alpha-aldose to the beta-anomer galM2 - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim GZD1_k127_2692186_3 886293.Sinac_0949 3.381e-179 599.0 COG3250@1|root,COG3250@2|Bacteria,2IWTW@203682|Planctomycetes 203682|Planctomycetes G Glycosyl hydrolases family 2 - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Glyco_hydro_43 GZD1_k127_2692186_0 861299.J421_1402 2.07e-304 956.0 COG2091@1|root,COG2091@2|Bacteria,1ZUPU@142182|Gemmatimonadetes 2|Bacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 GZD1_k127_2692186_24 1008459.TASI_0219 8.759e-06 58.0 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2VMKG@28216|Betaproteobacteria,3T56V@506|Alcaligenaceae 28216|Betaproteobacteria E Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA - - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 GZD1_k127_2692186_20 502025.Hoch_4438 1.622e-28 132.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YUYF@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 GZD1_k127_2692186_11 518766.Rmar_1797 3.805e-94 327.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1FJ5I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Bacterial regulatory protein, Fis family ntrX - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_2692186_6 861299.J421_4076 2.361e-154 497.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 GZD1_k127_2692186_23 1307761.L21SP2_1647 8.437e-10 69.0 COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes 203691|Spirochaetes S tetratricopeptide repeat lmp1 - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8 GZD1_k127_2692186_7 485913.Krac_12089 1.17e-147 490.0 COG2303@1|root,COG2303@2|Bacteria,2G7EB@200795|Chloroflexi 200795|Chloroflexi E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N GZD1_k127_2692186_4 926550.CLDAP_00280 5.628e-170 542.0 COG1257@1|root,COG1257@2|Bacteria 2|Bacteria I hydroxymethylglutaryl-CoA reductase (NADPH) activity hmgA - 1.1.1.34 ko:K00021 ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976 M00095 R02082 RC00004,RC00644 ko00000,ko00001,ko00002,ko01000 - - - HMG-CoA_red GZD1_k127_2692186_5 861299.J421_4293 3.812e-156 531.0 COG0661@1|root,COG0661@2|Bacteria,1ZSYX@142182|Gemmatimonadetes 2|Bacteria S ABC1 family ubiB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - ko:K03688 - - - - ko00000 - - iYL1228.KPN_04331 ABC1 GZD1_k127_2692186_17 880071.Fleli_0316 3.124e-54 206.0 COG0204@1|root,COG0204@2|Bacteria,4NJDA@976|Bacteroidetes,47MU0@768503|Cytophagia 976|Bacteroidetes I Phosphate acyltransferases - - - - - - - - - - - - - GZD1_k127_2692186_9 351348.Maqu_0816 8.95e-113 376.0 COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - Patatin GZD1_k127_2692186_22 522306.CAP2UW1_3347 2.921e-12 78.0 COG3937@1|root,COG3937@2|Bacteria,1N1EW@1224|Proteobacteria,2WFRP@28216|Betaproteobacteria 28216|Betaproteobacteria S Poly(hydroxyalcanoate) granule associated protein (phasin) - - - - - - - - - - - - Phasin GZD1_k127_2692186_16 861299.J421_3685 1.642e-63 224.0 COG0231@1|root,COG0231@2|Bacteria,1ZT2N@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C GZD1_k127_2692186_1 240015.ACP_0487 3.168e-225 739.0 COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria 57723|Acidobacteria S cellulose binding - - - - - - - - - - - - - GZD1_k127_2692186_21 1471459.JFLJ01000040_gene777 1.445e-15 81.0 COG0745@1|root,COG0745@2|Bacteria,1G1EZ@1117|Cyanobacteria,1MKDA@1212|Prochloraceae 1117|Cyanobacteria T Alternative locus ID rpaA - - ko:K10697 ko02020,map02020 M00467 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C GZD1_k127_2692186_15 1479238.JQMZ01000001_gene1564 2.743e-64 226.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,43XGD@69657|Hyphomonadaceae 28211|Alphaproteobacteria L glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco GZD1_k127_2692186_10 1379270.AUXF01000003_gene3366 1.356e-110 371.0 COG0389@1|root,COG0389@2|Bacteria,1ZT65@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C GZD1_k127_2692186_19 906968.Trebr_2330 7.592e-30 128.0 COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes 203691|Spirochaetes S PFAM Rhomboid family - - - - - - - - - - - - Rhomboid GZD1_k127_2692186_14 861299.J421_1806 2.408e-64 239.0 COG3258@1|root,COG3258@2|Bacteria,1ZUR6@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome C oxidase, cbb3-type, subunit III - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - - GZD1_k127_2692186_18 485918.Cpin_2598 2.22e-51 196.0 COG1416@1|root,COG1416@2|Bacteria,4NH85@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - GZD1_k127_2692186_12 861299.J421_0341 4.281e-84 286.0 COG0745@1|root,COG0745@2|Bacteria,1ZUFQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C GZD1_k127_2692186_13 861299.J421_0342 2.686e-66 247.0 COG0642@1|root,COG2205@2|Bacteria,1ZUZJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA GZD1_k127_2692186_2 1267535.KB906767_gene1569 5.076e-217 692.0 COG2234@1|root,COG2234@2|Bacteria,3Y435@57723|Acidobacteria 57723|Acidobacteria S Transferrin receptor-like dimerisation domain - - 3.4.17.21 ko:K01301 - - - - ko00000,ko01000,ko01002 - - - PA,Peptidase_M28,TFR_dimer GZD1_k127_2754599_1 1379270.AUXF01000004_gene3046 3.142e-233 724.0 COG0086@1|root,COG0303@1|root,COG0086@2|Bacteria,COG0303@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 GZD1_k127_2754599_0 1379698.RBG1_1C00001G1605 0.0 1380.0 COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 GZD1_k127_2754599_5 935863.AWZR01000015_gene2482 1.149e-38 148.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1X6DQ@135614|Xanthomonadales 135614|Xanthomonadales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N GZD1_k127_2754599_3 861299.J421_2765 7.34e-48 185.0 COG0244@1|root,COG0244@2|Bacteria,1ZTQI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 GZD1_k127_2754599_2 861299.J421_2764 1.052e-94 321.0 COG0081@1|root,COG0081@2|Bacteria,1ZSS7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 GZD1_k127_2754599_4 334413.FMG_0539 5.755e-46 168.0 COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,22HEU@1570339|Peptoniphilaceae 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N GZD1_k127_2788636_0 1453498.LG45_12680 1.142e-57 227.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - - GZD1_k127_2788636_1 33035.JPJF01000073_gene4425 1.515e-10 75.0 COG1361@1|root,COG3386@1|root,COG1361@2|Bacteria,COG3386@2|Bacteria,1UQ5B@1239|Firmicutes,24AUI@186801|Clostridia 186801|Clostridia M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,DUF3794,SdrD_B GZD1_k127_2811_0 1211114.ALIP01000113_gene866 7.297e-145 476.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1X3MQ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD GZD1_k127_2861371_38 682795.AciX8_1433 1.547e-36 144.0 COG3394@1|root,COG3394@2|Bacteria,3Y441@57723|Acidobacteria,2JI4E@204432|Acidobacteriia 204432|Acidobacteriia G YdjC-like protein - - - - - - - - - - - - YdjC GZD1_k127_2861371_35 926569.ANT_00990 2.567e-41 164.0 COG1215@1|root,COG1215@2|Bacteria,2GA7S@200795|Chloroflexi 200795|Chloroflexi M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_2861371_27 700598.Niako_4637 4.519e-69 241.0 2CYFR@1|root,32T44@2|Bacteria,4P6IN@976|Bacteroidetes,1IZDY@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF998) - - - - - - - - - - - - DUF998 GZD1_k127_2861371_47 926690.KE386573_gene1677 2.69e-10 71.0 COG0589@1|root,arCOG00449@2157|Archaea,2XVPB@28890|Euryarchaeota,23SHQ@183963|Halobacteria 183963|Halobacteria T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp GZD1_k127_2861371_11 69395.JQLZ01000003_gene279 3.471e-148 479.0 COG0520@1|root,COG0520@2|Bacteria,1PJFD@1224|Proteobacteria,2V96M@28211|Alphaproteobacteria,2KJQT@204458|Caulobacterales 204458|Caulobacterales E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 GZD1_k127_2861371_12 1379270.AUXF01000002_gene1583 1.947e-143 491.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1583|- KLT protein kinase activity - - - - - - - - - - - - - GZD1_k127_2861371_4 861299.J421_3091 2.359e-266 834.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process - - - - - - - - - - - - Peptidase_M1 GZD1_k127_2861371_43 1536775.H70737_03140 2.625e-19 98.0 COG3708@1|root,COG3708@2|Bacteria,1VFMZ@1239|Firmicutes,4IPZY@91061|Bacilli,26ZUI@186822|Paenibacillaceae 91061|Bacilli K Putative zinc ribbon domain - - - - - - - - - - - - Zn_ribbon_2 GZD1_k127_2861371_42 314345.SPV1_03163 1.163e-19 94.0 COG1765@1|root,COG1765@2|Bacteria 2|Bacteria O OsmC-like protein ycaO - - ko:K09136 - - - - ko00000,ko03009 - - - OsmC,YcaO GZD1_k127_2861371_40 526227.Mesil_2837 5.266e-34 145.0 COG1917@1|root,COG1917@2|Bacteria,1WMIY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - GZD1_k127_2861371_30 1079986.JH164846_gene1951 3.3e-64 225.0 COG1335@1|root,COG1335@2|Bacteria,2I9AW@201174|Actinobacteria 201174|Actinobacteria Q isochorismatase hydrolase - - - - - - - - - - - - Isochorismatase GZD1_k127_2861371_29 682795.AciX8_1703 7.408e-66 241.0 COG0229@1|root,COG0229@2|Bacteria,3Y6UH@57723|Acidobacteria,2JMMX@204432|Acidobacteriia 204432|Acidobacteriia O PFAM Methionine sulfoxide reductase B - - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR GZD1_k127_2861371_26 526227.Mesil_1512 5.422e-70 242.0 COG1881@1|root,COG1881@2|Bacteria,1WKIM@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP GZD1_k127_2861371_36 379066.GAU_0800 6.704e-40 151.0 COG3682@1|root,COG3682@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - Penicillinase_R GZD1_k127_2861371_34 1519464.HY22_08540 2.946e-52 200.0 COG2819@1|root,COG2819@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Esterase GZD1_k127_2861371_5 861299.J421_4130 7.944e-248 799.0 COG1629@1|root,COG4771@2|Bacteria,1ZVAQ@142182|Gemmatimonadetes 2|Bacteria P TonB dependent receptor susC - - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_2861371_9 861299.J421_4129 4.143e-181 586.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB GZD1_k127_2861371_6 861299.J421_4127 4.558e-229 725.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.2.1.1,3.2.1.41 ko:K01176,ko:K01200 ko00500,ko01100,ko01110,ko04973,map00500,map01100,map01110,map04973 - R02108,R02111,R02112,R11262 - ko00000,ko00001,ko01000 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM26,CBM_20,CBM_25,CBM_48,PUD GZD1_k127_2861371_8 861299.J421_4128 2.294e-184 594.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH13 iLJ478.TM1840 Alpha-amylase,DUF1945,DUF3459 GZD1_k127_2861371_41 1191523.MROS_2687 9.098e-27 114.0 COG2827@1|root,COG2827@2|Bacteria 2|Bacteria L Endonuclease containing a URI domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG GZD1_k127_2861371_14 518766.Rmar_1813 1.007e-111 376.0 COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,1FIXN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Glycogen debranching enzyme, glucanotransferase domain - - - - - - - - - - - - Alpha-amylase,Malt_amylase_C GZD1_k127_2861371_3 1379270.AUXF01000003_gene3768 4.205e-272 852.0 COG3023@1|root,COG3023@2|Bacteria 2|Bacteria V N-Acetylmuramoyl-L-alanine amidase - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 GZD1_k127_2861371_19 1121468.AUBR01000021_gene2827 1.09e-93 330.0 COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,42FUX@68295|Thermoanaerobacterales 186801|Clostridia G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 GZD1_k127_2861371_7 313596.RB2501_12662 4.536e-187 595.0 COG2211@1|root,COG2211@2|Bacteria,4NE3F@976|Bacteroidetes,1HWRM@117743|Flavobacteriia 976|Bacteroidetes G major facilitator - - - ko:K16211 - - - - ko00000,ko02000 2.A.2.6 - - MFS_1,MFS_2 GZD1_k127_2861371_1 1191523.MROS_0969 1.671e-290 914.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N GZD1_k127_2861371_33 1209984.BN978_05486 3.528e-53 190.0 COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,238S4@1762|Mycobacteriaceae 201174|Actinobacteria S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt GZD1_k127_2861371_22 1156919.QWC_27596 2.887e-78 269.0 COG1280@1|root,COG1280@2|Bacteria,1R7UJ@1224|Proteobacteria,2WFM7@28216|Betaproteobacteria,3T656@506|Alcaligenaceae 28216|Betaproteobacteria E LysE type translocator - - - - - - - - - - - - LysE GZD1_k127_2861371_17 1340493.JNIF01000004_gene83 1.735e-107 366.0 COG2513@1|root,COG2513@2|Bacteria 2|Bacteria G methylisocitrate lyase activity - - - - - - - - - - - - PEP_mutase GZD1_k127_2861371_21 1028801.RG1141_CH38430 8.998e-82 286.0 COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2U16Z@28211|Alphaproteobacteria,4BDVS@82115|Rhizobiaceae 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF899) - - - - - - - - - - - - DUF899 GZD1_k127_2861371_2 861299.J421_1366 2.289e-284 897.0 COG0577@1|root,COG0577@2|Bacteria,1ZUNA@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_2861371_39 392499.Swit_3244 1.161e-35 149.0 COG0491@1|root,COG1418@1|root,COG0491@2|Bacteria,COG1418@2|Bacteria,1NGQE@1224|Proteobacteria,2TUZS@28211|Alphaproteobacteria,2KA9U@204457|Sphingomonadales 204457|Sphingomonadales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B GZD1_k127_2861371_16 1499967.BAYZ01000057_gene4683 6.431e-110 392.0 COG0210@1|root,COG0210@2|Bacteria,2NQHW@2323|unclassified Bacteria 2|Bacteria L 3' exoribonuclease, RNase T-like - - 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - RNase_T,UvrD-helicase,UvrD_C GZD1_k127_2861371_48 1288484.APCS01000061_gene2967 6.038e-05 51.0 COG2318@1|root,COG2318@2|Bacteria,1WMSX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S DinB family - - - - - - - - - - - - DinB GZD1_k127_2861371_20 243090.RB7928 2.025e-89 335.0 COG0515@1|root,COG1714@1|root,COG0515@2|Bacteria,COG1714@2|Bacteria,2IY76@203682|Planctomycetes 203682|Planctomycetes KLT COG0515 Serine threonine protein - - - - - - - - - - - - Pkinase,RDD GZD1_k127_2861371_0 1267534.KB906760_gene1359 1.452e-302 968.0 COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria,2JM6Q@204432|Acidobacteriia 204432|Acidobacteriia S Penicillin amidase - - - - - - - - - - - - Penicil_amidase GZD1_k127_2861371_37 861299.J421_1752 1.376e-39 169.0 2DWGD@1|root,3407S@2|Bacteria,1ZV24@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg GZD1_k127_2861371_45 1082931.KKY_2436 1.187e-12 80.0 2EFVW@1|root,339N3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_2861371_31 28042.GU90_07075 4.244e-62 226.0 2DBMA@1|root,2Z9Y3@2|Bacteria,2I9ER@201174|Actinobacteria,4E2VY@85010|Pseudonocardiales 201174|Actinobacteria S Domain of unknown function (DUF4389) - - - - - - - - - - - - DUF4389 GZD1_k127_2861371_15 234267.Acid_5600 2.723e-111 373.0 COG3391@1|root,COG3391@2|Bacteria,3Y48Y@57723|Acidobacteria 57723|Acidobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - - GZD1_k127_2861371_28 479434.Sthe_3085 3.278e-68 242.0 COG0725@1|root,COG0725@2|Bacteria,2G6J6@200795|Chloroflexi,27Y90@189775|Thermomicrobia 189775|Thermomicrobia P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 GZD1_k127_2861371_25 1382306.JNIM01000001_gene3823 6.399e-74 257.0 COG4149@1|root,COG4149@2|Bacteria,2G6FA@200795|Chloroflexi 200795|Chloroflexi P Binding-protein-dependent transport system inner membrane component - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 GZD1_k127_2861371_18 1382306.JNIM01000001_gene3476 1.033e-93 320.0 COG3842@1|root,COG3842@2|Bacteria,2G5JJ@200795|Chloroflexi 200795|Chloroflexi P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010,ko:K02052 ko02010,ko02024,map02010,map02024 M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11 - - ABC_tran,TOBE_2 GZD1_k127_2861371_24 1163617.SCD_n01861 4.042e-74 274.0 COG3437@1|root,COG3829@1|root,COG4251@1|root,COG3437@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VQYK@28216|Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 GZD1_k127_2861371_23 1440053.JOEI01000032_gene5424 5.303e-76 265.0 COG0583@1|root,COG0583@2|Bacteria,2GK13@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate GZD1_k127_2861371_10 204669.Acid345_3014 1.499e-154 509.0 COG0784@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,3Y64H@57723|Acidobacteria,2JM5F@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg GZD1_k127_2861371_13 861299.J421_3611 6.611e-135 440.0 COG1301@1|root,COG1301@2|Bacteria,1ZT91@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sodium:dicarboxylate symporter family - - - ko:K11102 - - - - ko00000,ko02000 2.A.23.1.1,2.A.23.1.2 - - SDF GZD1_k127_2861371_32 313612.L8106_01707 3.011e-53 206.0 COG2199@1|root,COG3447@1|root,COG2199@2|Bacteria,COG3447@2|Bacteria 2|Bacteria T MASE1 domain protein - - - ko:K07216 - - - - ko00000 - - - EAL,GAF,GGDEF,Hemerythrin,MASE1,PAS_3,PAS_4,PAS_8,PAS_9 GZD1_k127_2861371_46 379066.GAU_2889 5.278e-11 66.0 COG2060@1|root,COG2060@2|Bacteria 2|Bacteria P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane kdpA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 ko:K01546 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - iSB619.SA_RS00490 KdpA GZD1_k127_2911288_5 861299.J421_4298 1.617e-12 70.0 COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Multicopper oxidase - - 1.16.3.3 ko:K22348 - - - - ko00000,ko01000 - - - Cu-oxidase_2,Cu-oxidase_3 GZD1_k127_2911288_2 1267535.KB906767_gene1203 7.379e-54 198.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - AHSA1,HTH_20 GZD1_k127_2911288_4 1445613.JALM01000031_gene5424 7.696e-16 82.0 2B1QU@1|root,33JNP@2|Bacteria,2I838@201174|Actinobacteria,4E6FI@85010|Pseudonocardiales 201174|Actinobacteria S Protein of unknown function (DUF3224) - - - - - - - - - - - - DUF3224 GZD1_k127_2911288_1 1031711.RSPO_c02538 7.725e-75 253.0 COG3832@1|root,COG3832@2|Bacteria,1RB46@1224|Proteobacteria,2VTVP@28216|Betaproteobacteria,1K8WI@119060|Burkholderiaceae 28216|Betaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 GZD1_k127_2911288_3 1123073.KB899241_gene3444 2.516e-47 173.0 COG0640@1|root,COG0640@2|Bacteria,1RIJ9@1224|Proteobacteria,1SPFF@1236|Gammaproteobacteria,1XCQI@135614|Xanthomonadales 135614|Xanthomonadales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 GZD1_k127_2911288_0 404589.Anae109_4026 1.916e-140 449.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria,2YV3K@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolase 36 superfamily, catalytic domain - - 2.4.1.20 ko:K00702,ko:K13688 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000,ko01003 - GH94,GT36,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase GZD1_k127_301988_4 379066.GAU_0585 2.899e-60 212.0 COG2148@1|root,COG2148@2|Bacteria,1ZSW2@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf GZD1_k127_301988_2 861299.J421_2477 1.3e-96 324.0 COG1269@1|root,COG1269@2|Bacteria,1ZT23@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transmembrane exosortase (Exosortase_EpsH) - - - - - - - - - - - - Exosortase_EpsH GZD1_k127_301988_5 1379270.AUXF01000004_gene3333 5.644e-44 179.0 COG1269@1|root,COG1269@2|Bacteria,1ZTKR@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF3485) - - - - - - - - - - - - DUF3485 GZD1_k127_301988_3 1123228.AUIH01000025_gene3304 1.517e-60 235.0 COG1215@1|root,COG1215@2|Bacteria,1QUFX@1224|Proteobacteria,1RN4M@1236|Gammaproteobacteria,1XIME@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 GZD1_k127_301988_6 1452718.JBOY01000038_gene2005 5.715e-30 134.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1SYUH@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyl Transferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 GZD1_k127_301988_0 1232410.KI421418_gene2202 7.156e-135 441.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,42N0R@68525|delta/epsilon subdivisions,2WMPF@28221|Deltaproteobacteria,43U7D@69541|Desulfuromonadales 28221|Deltaproteobacteria S FAD dependent oxidoreductase - - - - - - - - - - - - DAO,Fer2_BFD GZD1_k127_301988_1 670307.HYPDE_29563 3.45e-99 329.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria,3N8AF@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 GZD1_k127_3051124_7 379066.GAU_2956 1.264e-42 161.0 COG0662@1|root,COG0662@2|Bacteria,1ZVA1@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Cupin domain - - - - - - - - - - - - Cupin_2 GZD1_k127_3051124_14 1996.JOFO01000020_gene2371 2.55e-19 90.0 COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,2II8Q@201174|Actinobacteria,4EQ3P@85012|Streptosporangiales 201174|Actinobacteria S Divergent 4Fe-4S mono-cluster - - - - - - - - - - - - Fer4_19,zf-CDGSH GZD1_k127_3051124_15 886882.PPSC2_c2409 1.436e-18 92.0 COG2133@1|root,COG2133@2|Bacteria,1VBUK@1239|Firmicutes,4HKNP@91061|Bacilli,26YMI@186822|Paenibacillaceae 91061|Bacilli G CHRD domain - - - - - - - - - - - - CHRD GZD1_k127_3051124_16 945713.IALB_2682 1.847e-18 94.0 2B2YN@1|root,31VJM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_3051124_1 861299.J421_2042 3.451e-240 754.0 COG0308@1|root,COG0308@2|Bacteria,1ZU50@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 GZD1_k127_3051124_12 604331.AUHY01000004_gene917 3.541e-37 157.0 COG1597@1|root,COG1597@2|Bacteria,1WI0N@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I PFAM Diacylglycerol kinase, catalytic bmrU - - - - - - - - - - - DAGK_cat GZD1_k127_3051124_18 861299.J421_3196 2.336e-06 59.0 2FIMZ@1|root,34ADU@2|Bacteria,1ZTYV@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3051124_4 861299.J421_3197 5.426e-94 316.0 COG0796@1|root,COG0796@2|Bacteria,1ZUQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race GZD1_k127_3051124_11 861299.J421_3198 1.916e-39 156.0 COG2908@1|root,COG2908@2|Bacteria,1ZTNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Calcineurin-like phosphoesterase - - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos GZD1_k127_3051124_3 861299.J421_3023 1.408e-147 476.0 COG0274@1|root,COG0274@2|Bacteria,1ZSX9@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate - - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC GZD1_k127_3051124_0 861299.J421_3024 0.0 1181.0 COG1012@1|root,COG1012@2|Bacteria,1ZT7A@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh GZD1_k127_3051124_6 1511.CLOST_1915 3.107e-46 180.0 COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,25S2P@186804|Peptostreptococcaceae 186801|Clostridia Q Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate pduL - 2.3.1.8 ko:K15024 ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200 M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans,PTAC GZD1_k127_3051124_13 861299.J421_3199 1.553e-31 130.0 COG0824@1|root,COG0824@2|Bacteria,1ZTY3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT GZD1_k127_3051124_10 1089550.ATTH01000001_gene840 5.03e-40 170.0 COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,4PF1U@976|Bacteroidetes,1FK0E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes CO Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - HEAT_2,Pro_isomerase GZD1_k127_3051124_2 880073.Calab_2849 1.543e-164 573.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 GZD1_k127_3051124_17 379066.GAU_1568 2.045e-09 67.0 2F5A9@1|root,33XWF@2|Bacteria,1ZTU9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3051124_9 861299.J421_3201 8.84e-41 158.0 2EPTK@1|root,33HE4@2|Bacteria,1ZTUK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lipopolysaccharide-assembly - - - - - - - - - - - - LptE GZD1_k127_3051124_5 861299.J421_3202 1.298e-49 186.0 COG0615@1|root,COG0615@2|Bacteria,1ZTPI@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - - - - - - - - - - CTP_transf_like GZD1_k127_3051124_8 401526.TcarDRAFT_1170 4.212e-41 159.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,4H4DD@909932|Negativicutes 909932|Negativicutes F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like GZD1_k127_3105515_1 697284.ERIC2_c01880 5.673e-55 210.0 COG1898@1|root,COG1898@2|Bacteria,1TRVB@1239|Firmicutes,4HFQB@91061|Bacilli,26Y1U@186822|Paenibacillaceae 91061|Bacilli G Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC3 - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom GZD1_k127_3105515_0 251229.Chro_2348 5.156e-178 569.0 COG2227@1|root,COG2227@2|Bacteria,1G06X@1117|Cyanobacteria,3VJGG@52604|Pleurocapsales 1117|Cyanobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 GZD1_k127_3105515_2 35754.JNYJ01000029_gene9455 1.074e-48 177.0 COG0001@1|root,COG0001@2|Bacteria,2GKJV@201174|Actinobacteria,4DEN9@85008|Micromonosporales 201174|Actinobacteria H Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,Methyltransf_13,Methyltransf_14 GZD1_k127_3116587_23 945713.IALB_2907 2.804e-45 188.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_3116587_14 1278073.MYSTI_04054 1.467e-75 264.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,42RCM@68525|delta/epsilon subdivisions,2WN89@28221|Deltaproteobacteria 28221|Deltaproteobacteria K response regulator - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg GZD1_k127_3116587_17 1278073.MYSTI_05666 9.817e-61 224.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase GZD1_k127_3116587_27 324602.Caur_3390 1.958e-40 164.0 COG2947@1|root,COG2947@2|Bacteria,2G93S@200795|Chloroflexi,375T3@32061|Chloroflexia 32061|Chloroflexia S EVE domain - - - - - - - - - - - - EVE GZD1_k127_3116587_16 1071679.BG57_30430 5.473e-64 233.0 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2VRRK@28216|Betaproteobacteria,1K14S@119060|Burkholderiaceae 28216|Betaproteobacteria S Hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - DLH GZD1_k127_3116587_1 861299.J421_5987 7.24e-307 964.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria 2|Bacteria L DNA ligase (ATP) activity - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N GZD1_k127_3116587_13 861299.J421_5988 1.63e-81 282.0 COG1273@1|root,COG1273@2|Bacteria 2|Bacteria M With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku GZD1_k127_3116587_15 443144.GM21_0222 2.41e-75 260.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 GZD1_k127_3116587_0 861299.J421_0900 4.732e-309 963.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZT9R@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 GZD1_k127_3116587_19 1120949.KB903328_gene8870 2.601e-54 203.0 COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4D8PV@85008|Micromonosporales 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_3116587_8 1117958.PE143B_0103005 8.864e-100 334.0 COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria 1224|Proteobacteria V transport, permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane GZD1_k127_3116587_7 580332.Slit_0578 1.828e-103 343.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,44VG9@713636|Nitrosomonadales 28216|Betaproteobacteria V PFAM ABC transporter related - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran GZD1_k127_3116587_26 398527.Bphyt_5419 5.778e-42 156.0 COG5470@1|root,COG5470@2|Bacteria,1RIH6@1224|Proteobacteria,2VSR7@28216|Betaproteobacteria,1K8VQ@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM NIPSNAP family containing protein - - - - - - - - - - - - NIPSNAP GZD1_k127_3116587_9 861299.J421_3723 1.392e-97 339.0 COG0457@1|root,COG2206@1|root,COG0457@2|Bacteria,COG2206@2|Bacteria 2|Bacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - CHASE6_C,DICT,GerE,HD,HD_5 GZD1_k127_3116587_39 861299.J421_2102 3.555e-09 64.0 2C5K1@1|root,2ZR6Y@2|Bacteria,1ZV9C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3116587_12 709986.Deima_2139 1.699e-83 291.0 COG0395@1|root,COG0395@2|Bacteria 2|Bacteria P glycerophosphodiester transmembrane transport irk - - ko:K02026,ko:K08715 - M00207 - - ko00000,ko00002,ko02000 1.A.2.2,3.A.1.1 - - IRK GZD1_k127_3116587_6 1382359.JIAL01000001_gene536 8.122e-178 578.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds gtfB GO:0005575,GO:0005576 2.4.1.5 ko:K00689 ko00500,ko02020,map00500,map02020 - R02120,R06066 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,CW_binding_1,Glyco_hydro_70 GZD1_k127_3116587_3 1267535.KB906767_gene4346 1.976e-199 647.0 COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia 204432|Acidobacteriia S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 GZD1_k127_3116587_22 595460.RRSWK_00985 1.026e-46 180.0 COG1796@1|root,COG1796@2|Bacteria 2|Bacteria L DNA-directed DNA polymerase activity dpbF - 3.1.11.5 ko:K02347,ko:K03581,ko:K04477 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,HHH_8 GZD1_k127_3116587_25 235985.BBPN01000020_gene6544 6.178e-43 166.0 2CHZY@1|root,32YTS@2|Bacteria,2GV6U@201174|Actinobacteria,2NERQ@228398|Streptacidiphilus 201174|Actinobacteria - - - - - - - - - - - - - - - GZD1_k127_3116587_28 1185876.BN8_01108 3.952e-38 148.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,47QGD@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 GZD1_k127_3116587_24 550540.Fbal_1383 6.024e-44 166.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,1S3T6@1236|Gammaproteobacteria 1236|Gammaproteobacteria H synthase queD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0070497,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - iECIAI39_1322.ECIAI39_2947,iUTI89_1310.UTI89_C3129,ic_1306.c3324 PTPS GZD1_k127_3116587_10 479435.Kfla_0827 2.118e-92 315.0 COG0602@1|root,COG0602@2|Bacteria,2I9R3@201174|Actinobacteria,4DSU3@85009|Propionibacteriales 201174|Actinobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM GZD1_k127_3116587_11 215803.DB30_7393 9.916e-85 297.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2Z04D@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_3075 QueC GZD1_k127_3116587_21 1121936.AUHI01000007_gene2364 1.847e-48 177.0 COG0780@1|root,COG0780@2|Bacteria,1TPYC@1239|Firmicutes,4HB14@91061|Bacilli 91061|Bacilli S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF GZD1_k127_3116587_38 883126.HMPREF9710_03723 4.573e-17 91.0 COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria,474H3@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS GZD1_k127_3116587_4 861299.J421_1232 7.969e-195 632.0 COG4993@1|root,COG4993@2|Bacteria 2|Bacteria G Dehydrogenase - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 GZD1_k127_3116587_30 313606.M23134_05112 2.558e-34 145.0 COG2972@1|root,COG2972@2|Bacteria,4NK4J@976|Bacteroidetes,47R2T@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase GZD1_k127_3116587_18 861299.J421_2096 2.12e-59 220.0 COG3279@1|root,COG3279@2|Bacteria,1ZTKG@142182|Gemmatimonadetes 2|Bacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - EAL,LytTR,Response_reg GZD1_k127_3116587_33 234267.Acid_7925 1.149e-30 126.0 COG3832@1|root,COG3832@2|Bacteria,3Y94H@57723|Acidobacteria 57723|Acidobacteria J glyoxalase III activity - - - - - - - - - - - - - GZD1_k127_3116587_31 797209.ZOD2009_10355 4.032e-34 145.0 arCOG13341@1|root,arCOG13341@2157|Archaea,2XXWE@28890|Euryarchaeota,23WKG@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - GZD1_k127_3116587_29 1230460.C495_09230 1.818e-37 149.0 COG4635@1|root,arCOG00524@2157|Archaea,2XXEG@28890|Euryarchaeota,23V7A@183963|Halobacteria 183963|Halobacteria C COG4635 Flavodoxin - - 1.3.5.3 ko:K00230 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R09489 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_5 GZD1_k127_3116587_20 1211114.ALIP01000079_gene658 3.875e-50 183.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,1X6DF@135614|Xanthomonadales 135614|Xanthomonadales L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N GZD1_k127_3116587_41 1227484.C471_12316 0.0003959 49.0 arCOG08914@1|root,arCOG08914@2157|Archaea,2XZSA@28890|Euryarchaeota,23XNV@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - GZD1_k127_3116587_35 861299.J421_4072 1.775e-21 107.0 COG2010@1|root,COG2010@2|Bacteria,1ZU6E@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N GZD1_k127_3116587_2 861299.J421_4070 7.032e-229 721.0 COG4993@1|root,COG4993@2|Bacteria 2|Bacteria G Dehydrogenase - - - - - - - - - - - - PQQ,PQQ_2 GZD1_k127_3116587_34 379066.GAU_0906 1.383e-28 121.0 COG2839@1|root,COG2839@2|Bacteria,1ZUVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF456) - - - ko:K09793 - - - - ko00000 - - - DUF456 GZD1_k127_3116587_36 37919.EP51_35085 4.975e-20 106.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4G9JD@85025|Nocardiaceae 201174|Actinobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,Trans_reg_C GZD1_k127_3116587_40 290397.Adeh_2190 3.192e-08 65.0 2E3HM@1|root,32YG7@2|Bacteria,1RFJA@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - GZD1_k127_3116587_32 865937.Gilli_1014 4.695e-31 139.0 2C5G3@1|root,2Z8TT@2|Bacteria,4P166@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - GZD1_k127_3116587_5 1379270.AUXF01000002_gene1600 3.266e-188 620.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - GZD1_k127_3116587_37 543728.Vapar_1792 7.672e-19 87.0 2AY99@1|root,31QBJ@2|Bacteria,1RI92@1224|Proteobacteria,2VSPH@28216|Betaproteobacteria,4AEEU@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_3151486_12 330214.NIDE3547 1.895e-07 63.0 COG0582@1|root,COG0582@2|Bacteria,3J133@40117|Nitrospirae 40117|Nitrospirae L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase GZD1_k127_3151486_3 379066.GAU_3920 9.791e-83 299.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1ZTYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Leishmanolysin - - - - - - - - - - - - Peptidase_M8 GZD1_k127_3151486_11 670487.Ocepr_2066 2.137e-13 75.0 COG2005@1|root,COG2005@2|Bacteria,1WMXH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Bacterial regulatory helix-turn-helix protein, lysR family - - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1 GZD1_k127_3151486_6 1193181.BN10_50002 4.632e-35 154.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria 201174|Actinobacteria M PFAM peptidase M6, immune inhibitor A - - - - - - - - - - - - Peptidase_M6 GZD1_k127_3151486_2 1267533.KB906734_gene4420 3.062e-83 303.0 COG0531@1|root,COG0531@2|Bacteria,3Y4PR@57723|Acidobacteria,2JJPB@204432|Acidobacteriia 204432|Acidobacteriia E Amino acid permease - - - ko:K20265 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.3.7.1,2.A.3.7.3 - - AA_permease_2 GZD1_k127_3151486_10 1123278.KB893402_gene3333 1.151e-14 83.0 COG0671@1|root,COG0671@2|Bacteria,4NMQW@976|Bacteroidetes,47PHH@768503|Cytophagia 976|Bacteroidetes I Acid phosphatase homologues - - - - - - - - - - - - PAP2 GZD1_k127_3151486_0 861299.J421_0795 3.124e-158 508.0 COG0156@1|root,COG0156@2|Bacteria,1ZST6@142182|Gemmatimonadetes 2|Bacteria H Beta-eliminating lyase bioF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 GZD1_k127_3151486_1 1144275.COCOR_04256 5.179e-107 361.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales 28221|Deltaproteobacteria K acetyltransferase - - - - - - - - - - - - - GZD1_k127_3151486_5 1123376.AUIU01000012_gene1445 5.912e-46 190.0 COG0451@1|root,COG0451@2|Bacteria,3J0T9@40117|Nitrospirae 40117|Nitrospirae M NmrA-like family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase GZD1_k127_3151486_9 1379698.RBG1_1C00001G0055 8.798e-19 101.0 COG0671@1|root,COG0671@2|Bacteria,2NRVZ@2323|unclassified Bacteria 2|Bacteria I PAP2 superfamily - - - - - - - - - - - - PAP2_3 GZD1_k127_3151486_15 1048339.KB913029_gene4390 0.0009807 51.0 COG3794@1|root,COG3794@2|Bacteria,2IR44@201174|Actinobacteria 201174|Actinobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - GZD1_k127_3151486_8 861299.J421_1276 1.13e-22 104.0 COG3794@1|root,COG3794@2|Bacteria,1ZTTE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Copper binding proteins, plastocyanin/azurin family - - - ko:K02638 ko00195,map00195 - - - ko00000,ko00001,ko00194 - - - Copper-bind GZD1_k127_3151486_4 644966.Tmar_0252 6.37e-62 229.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese GZD1_k127_3151486_7 379066.GAU_3049 6.127e-31 127.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNW@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_3151486_14 1382356.JQMP01000003_gene2144 0.0002787 48.0 COG3468@1|root,COG5662@1|root,COG3468@2|Bacteria,COG5662@2|Bacteria,2GBGZ@200795|Chloroflexi,27XXW@189775|Thermomicrobia 189775|Thermomicrobia K Putative zinc-finger - - - - - - - - - - - - zf-HC2 GZD1_k127_3157265_2 658086.HMPREF0994_06212 2.417e-16 87.0 COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,27IW0@186928|unclassified Lachnospiraceae 186801|Clostridia J tRNA nucleotidyltransferase domain 2 putative cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 GZD1_k127_3157265_1 861299.J421_3509 6.91e-68 240.0 COG0428@1|root,COG0428@2|Bacteria 2|Bacteria P transporter zupT - - ko:K07238,ko:K11021,ko:K16267 - - - - ko00000,ko02000,ko02042 2.A.5.4.11,2.A.5.5 - - Zip GZD1_k127_3157265_0 861299.J421_3508 3.351e-153 496.0 COG2256@1|root,COG2256@2|Bacteria,1ZTCA@142182|Gemmatimonadetes 142182|Gemmatimonadetes L MgsA AAA+ ATPase C terminal - - - ko:K07478 - - - - ko00000 - - - AAA_assoc_2,MgsA_C,RuvB_N GZD1_k127_3157265_3 1192124.LIG30_4296 2.166e-14 82.0 COG0394@1|root,COG0394@2|Bacteria,1N0DZ@1224|Proteobacteria,2VT1B@28216|Betaproteobacteria,1K8BQ@119060|Burkholderiaceae 28216|Betaproteobacteria T Low molecular weight phosphotyrosine protein phosphatase epsP - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc GZD1_k127_3264186_4 1499967.BAYZ01000113_gene2944 8.135e-17 84.0 COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria 2|Bacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 GZD1_k127_3264186_0 383372.Rcas_4029 4.293e-294 918.0 COG0480@1|root,COG0480@2|Bacteria,2G63B@200795|Chloroflexi,374TQ@32061|Chloroflexia 32061|Chloroflexia J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 GZD1_k127_3264186_2 861299.J421_2770 2.995e-70 243.0 COG0049@1|root,COG0049@2|Bacteria,1ZSQZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 GZD1_k127_3264186_3 880073.Calab_2121 2.654e-64 222.0 COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria 2|Bacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 GZD1_k127_3264186_1 1379270.AUXF01000004_gene3046 1.559e-80 271.0 COG0086@1|root,COG0303@1|root,COG0086@2|Bacteria,COG0303@2|Bacteria,1ZSZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 GZD1_k127_3310192_2 996637.SGM_4863 2.372e-74 254.0 COG4310@1|root,COG4310@2|Bacteria,2GK72@201174|Actinobacteria 201174|Actinobacteria S winged helix-turn-helix - - - - - - - - - - - - DUF2172,DUF4910,HTH_47,Peptidase_M28 GZD1_k127_3310192_3 861299.J421_0326 2.507e-71 257.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - 3.5.1.53 ko:K11206,ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase GZD1_k127_3310192_0 869210.Marky_0739 1.323e-144 468.0 COG0451@1|root,COG0451@2|Bacteria,1WMCY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase GZD1_k127_3310192_4 1510531.JQJJ01000008_gene3996 1.062e-31 144.0 COG2327@1|root,COG2327@2|Bacteria,1R6AN@1224|Proteobacteria,2U30E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Polysaccharide pyruvyl transferase amsJ - - - - - - - - - - - PS_pyruv_trans GZD1_k127_3310192_1 247490.KSU1_C1710 1.905e-76 270.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_tranf_2_5,Glycos_transf_2 GZD1_k127_3310192_5 414684.RC1_2529 5.044e-15 88.0 COG1216@1|root,COG1216@2|Bacteria,1N3SS@1224|Proteobacteria,2UHD0@28211|Alphaproteobacteria,2JX0U@204441|Rhodospirillales 204441|Rhodospirillales S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_3331443_59 1122228.AQXR01000011_gene404 0.0006898 53.0 COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4CZ2K@85004|Bifidobacteriales 201174|Actinobacteria L Recombination factor protein RarA rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N GZD1_k127_3331443_33 1120977.JHUX01000004_gene2282 2.466e-43 181.0 COG4643@1|root,COG4643@2|Bacteria,1R5M0@1224|Proteobacteria,1RY0K@1236|Gammaproteobacteria,3NMXK@468|Moraxellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3631) - - - - - - - - - - - - DUF3631 GZD1_k127_3331443_41 1313421.JHBV01000143_gene1140 2.932e-23 107.0 COG1403@1|root,COG1403@2|Bacteria,4NVU4@976|Bacteroidetes,1IZGU@117747|Sphingobacteriia 976|Bacteroidetes V HNH endonuclease - - - - - - - - - - - - HNH GZD1_k127_3331443_53 525373.HMPREF0766_10814 1.114e-05 53.0 2DXAF@1|root,3444E@2|Bacteria,4PNET@976|Bacteroidetes,1IY9I@117747|Sphingobacteriia 976|Bacteroidetes K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 GZD1_k127_3331443_36 1163617.SCD_n00128 7.34e-35 139.0 COG1403@1|root,COG1403@2|Bacteria,1NHCP@1224|Proteobacteria 1224|Proteobacteria V HNH nucleases - - - - - - - - - - - - HNH GZD1_k127_3331443_32 1121405.dsmv_3670 3.939e-45 179.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MIMV@213118|Desulfobacterales 28221|Deltaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase GZD1_k127_3331443_42 1117108.PAALTS15_25739 5.518e-23 103.0 2F626@1|root,33YKI@2|Bacteria,1VXHF@1239|Firmicutes,4HXAS@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - GZD1_k127_3331443_35 504472.Slin_3093 2.331e-36 146.0 COG3183@1|root,COG3183@2|Bacteria 2|Bacteria L HNH endonuclease - - - ko:K07451 - - - - ko00000,ko01000,ko02048 - - - HNH GZD1_k127_3331443_1 1382359.JIAL01000001_gene994 2.867e-240 757.0 COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria,2JISE@204432|Acidobacteriia 204432|Acidobacteriia J PFAM Amidase - - - - - - - - - - - - Amidase GZD1_k127_3331443_49 266940.Krad_3021 1.762e-09 71.0 COG4726@1|root,COG4726@2|Bacteria,2ID24@201174|Actinobacteria 201174|Actinobacteria NU pilus assembly protein PilW - - - - - - - - - - - - - GZD1_k127_3331443_55 56780.SYN_01761 1.349e-05 55.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane - - - ko:K02246,ko:K08084 - M00429 - - ko00000,ko00002,ko02044 3.A.15.2 - - GspH,N_methyl GZD1_k127_3331443_9 1121930.AQXG01000011_gene1720 3.588e-172 559.0 COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes 976|Bacteroidetes Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 GZD1_k127_3331443_14 1121930.AQXG01000011_gene1722 6.96e-126 425.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - LVIVD GZD1_k127_3331443_54 794903.OPIT5_00475 1.183e-05 57.0 COG0115@1|root,COG0115@2|Bacteria,46Y1J@74201|Verrucomicrobia,3K8SM@414999|Opitutae 414999|Opitutae EH Amino-transferase class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 GZD1_k127_3331443_23 1120973.AQXL01000119_gene530 1.134e-79 287.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4HB31@91061|Bacilli,279PI@186823|Alicyclobacillaceae 91061|Bacilli EH Anthranilate synthase component I, N terminal region pabB GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01665 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - - Anth_synt_I_N,Chorismate_bind GZD1_k127_3331443_18 1234364.AMSF01000036_gene241 1.394e-105 367.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1S9NJ@1236|Gammaproteobacteria,1X5C8@135614|Xanthomonadales 135614|Xanthomonadales P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - 1.14.12.1,1.14.15.7 ko:K00499,ko:K16319 ko00260,ko00627,ko01120,map00260,map00627,map01120 M00637 R00823,R00825,R07409 RC00087,RC00192 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske,Ring_hydroxyl_A GZD1_k127_3331443_11 521098.Aaci_0256 9.075e-154 492.0 COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,4HA4Q@91061|Bacilli,278WZ@186823|Alicyclobacillaceae 91061|Bacilli C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red GZD1_k127_3331443_17 1379698.RBG1_1C00001G0798 7.16e-106 377.0 COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - HEAT_2,Peptidase_M1 GZD1_k127_3331443_26 1379270.AUXF01000001_gene2323 1.573e-70 266.0 2EXVN@1|root,33R4S@2|Bacteria,1ZTD4@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3331443_28 861299.J421_4004 5.412e-65 231.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi GZD1_k127_3331443_22 402777.KB235904_gene3184 4.337e-81 277.0 COG4221@1|root,COG4221@2|Bacteria,1G182@1117|Cyanobacteria,1H965@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short GZD1_k127_3331443_6 1278073.MYSTI_04407 5.052e-197 631.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales 28221|Deltaproteobacteria J Amidase - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase GZD1_k127_3331443_57 661367.LLO_3136 0.0001641 55.0 COG1073@1|root,COG2885@1|root,COG1073@2|Bacteria,COG2885@2|Bacteria,1RFNW@1224|Proteobacteria,1SBNT@1236|Gammaproteobacteria,1JE7U@118969|Legionellales 118969|Legionellales M chlorophyll binding - - - - - - - - - - - - - GZD1_k127_3331443_8 861299.J421_1661 1.44e-177 568.0 COG0534@1|root,COG0534@2|Bacteria,1ZUGI@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MatE - - - - - - - - - - - - MatE GZD1_k127_3331443_51 945713.IALB_1179 1.815e-06 62.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_3331443_45 216432.CA2559_12863 2.541e-16 94.0 COG1470@1|root,COG1470@2|Bacteria,4NFPN@976|Bacteroidetes,1HXTQ@117743|Flavobacteriia 976|Bacteroidetes S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarbopepD_reg_2 GZD1_k127_3331443_24 1278073.MYSTI_00915 1.351e-73 264.0 COG4447@1|root,COG4447@2|Bacteria,1N3YV@1224|Proteobacteria 1224|Proteobacteria S cellulose binding - - - - - - - - - - - - PSII_BNR GZD1_k127_3331443_46 1380356.JNIK01000014_gene3116 3.795e-16 92.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT_2 GZD1_k127_3331443_12 66429.JOFL01000003_gene3387 3.394e-136 449.0 COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria 201174|Actinobacteria G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system rbsA - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran GZD1_k127_3331443_27 1123389.ATXJ01000029_gene120 3.884e-65 238.0 COG1172@1|root,COG1172@2|Bacteria,1WK1K@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G COGs COG1172 Ribose xylose arabinose galactoside ABC-type transport systems permease components - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 GZD1_k127_3331443_25 1183438.GKIL_3198 5.341e-71 264.0 COG1879@1|root,COG1879@2|Bacteria,1G06J@1117|Cyanobacteria 1117|Cyanobacteria G PFAM periplasmic binding protein LacI transcriptional regulator - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 GZD1_k127_3331443_7 886293.Sinac_7544 6.664e-180 604.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,2J4YH@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg GZD1_k127_3331443_44 861299.J421_2744 3.883e-18 97.0 29W2Z@1|root,30HMM@2|Bacteria,1ZTXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3331443_40 861299.J421_2743 6.074e-25 111.0 COG3088@1|root,COG3088@2|Bacteria,1ZTS7@142182|Gemmatimonadetes 142182|Gemmatimonadetes P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH GZD1_k127_3331443_4 861299.J421_2742 5.878e-237 750.0 COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome c-type biogenesis protein CcmF C-terminal - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm GZD1_k127_3331443_34 861299.J421_2741 8.448e-43 160.0 COG2332@1|root,COG2332@2|Bacteria,1ZTNV@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH - - - ko:K02197 - - - - ko00000 - - - CcmE GZD1_k127_3331443_47 349124.Hhal_0267 2.397e-15 91.0 COG0589@1|root,COG0589@2|Bacteria,1PEBI@1224|Proteobacteria,1SA3E@1236|Gammaproteobacteria,1WZV2@135613|Chromatiales 135613|Chromatiales T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp GZD1_k127_3331443_15 105420.BBPO01000004_gene1513 2.557e-120 403.0 COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,2NEW6@228398|Streptacidiphilus 201174|Actinobacteria O AIR synthase related protein, C-terminal domain hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C GZD1_k127_3331443_10 298653.Franean1_3401 3.483e-166 535.0 COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria 201174|Actinobacteria O hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - - HypD GZD1_k127_3331443_43 234267.Acid_6551 1.703e-21 98.0 COG0298@1|root,COG0298@2|Bacteria,3Y5NM@57723|Acidobacteria 57723|Acidobacteria O PFAM hydrogenase expression formation protein (HUPF HYPC) - - - ko:K04653 - - - - ko00000 - - - HupF_HypC GZD1_k127_3331443_5 1382306.JNIM01000001_gene189 7.781e-212 688.0 COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi 200795|Chloroflexi O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF GZD1_k127_3331443_29 665942.HMPREF1022_03080 3.171e-61 218.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2M883@213115|Desulfovibrionales 28221|Deltaproteobacteria KO Hydrogenase accessory protein HypB hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW GZD1_k127_3331443_56 234267.Acid_6931 0.0001259 47.0 COG0375@1|root,COG0375@2|Bacteria 2|Bacteria S nickel cation binding hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA GZD1_k127_3331443_37 269799.Gmet_3329 4.571e-32 136.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WPXK@28221|Deltaproteobacteria,43VTP@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM peptidase M52 hydrogen uptake protein hyaP - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - iAF987.Gmet_3329 HycI GZD1_k127_3331443_30 443143.GM18_1229 9.816e-51 194.0 COG1969@1|root,COG1969@2|Bacteria 2|Bacteria C respiratory electron transport chain cybH GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB GZD1_k127_3331443_0 398767.Glov_2055 2.747e-248 781.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hyaL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases GZD1_k127_3331443_13 698964.CDPW8_0672 1.832e-130 429.0 COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria,22KF9@1653|Corynebacteriaceae 201174|Actinobacteria C small subunit hoxK - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 GZD1_k127_3331443_19 1123392.AQWL01000007_gene876 3.081e-104 345.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria,1KSMU@119069|Hydrogenophilales 119069|Hydrogenophilales V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_3331443_3 489825.LYNGBM3L_63180 4.519e-239 771.0 COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales 1117|Cyanobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_3331443_21 1173024.KI912148_gene3731 2.09e-90 311.0 COG0845@1|root,COG0845@2|Bacteria,1G29R@1117|Cyanobacteria 1117|Cyanobacteria M Rnd family efflux transporter mfp subunit - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 GZD1_k127_3331443_38 1109445.AGSX01000083_gene3098 3.271e-31 135.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1SZ3S@1236|Gammaproteobacteria,1Z2VM@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc GZD1_k127_3331443_16 1317124.DW2_02894 2.047e-109 365.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,2XNXN@285107|Thioclava 28211|Alphaproteobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox GZD1_k127_3331443_31 1174528.JH992892_gene6574 1.244e-45 177.0 COG2823@1|root,COG2823@2|Bacteria,1GCMH@1117|Cyanobacteria 1117|Cyanobacteria S BON domain - - - - - - - - - - - - BON GZD1_k127_3331443_20 187272.Mlg_0096 4.338e-91 323.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1WW1M@135613|Chromatiales 135613|Chromatiales S ErfK YbiS YcfS YnhG family protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD GZD1_k127_3331443_2 1254432.SCE1572_36710 4.891e-240 758.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 GZD1_k127_3335579_0 1089550.ATTH01000001_gene487 4.194e-97 334.0 COG2067@1|root,COG2067@2|Bacteria,4NFFF@976|Bacteroidetes,1FIPQ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X GZD1_k127_3424670_0 1191523.MROS_0721 3.897e-135 440.0 COG1932@1|root,COG1932@2|Bacteria 2|Bacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 GZD1_k127_3424670_1 266117.Rxyl_0687 1.69e-59 217.0 COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4CPQ7@84995|Rubrobacteria 84995|Rubrobacteria S DinB superfamily - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - DinB_2,FGE-sulfatase GZD1_k127_3491679_1 1347086.CCBA010000012_gene2030 0.0001668 44.0 2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - GZD1_k127_3491679_0 926550.CLDAP_25850 3.47e-11 71.0 2ERYI@1|root,33JHP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_3491679_3 401473.BDP_1314 0.0006574 46.0 COG1598@1|root,COG1598@2|Bacteria,2IPZP@201174|Actinobacteria,4D0YY@85004|Bifidobacteriales 201174|Actinobacteria S HicB_like antitoxin of bacterial toxin-antitoxin system - - - - - - - - - - - - HicB_lk_antitox GZD1_k127_3491679_2 525904.Tter_0925 0.0003661 53.0 COG1066@1|root,COG1066@2|Bacteria 2|Bacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function - - - ko:K06919 - - - - ko00000 - - - AAA_16,AAA_25,DnaB GZD1_k127_3594081_32 1380394.JADL01000007_gene4523 1.521e-21 97.0 COG1835@1|root,COG1835@2|Bacteria,1MYXY@1224|Proteobacteria,2TVER@28211|Alphaproteobacteria,2JX1V@204441|Rhodospirillales 204441|Rhodospirillales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 GZD1_k127_3594081_37 1454004.AW11_01322 3.822e-07 57.0 COG1917@1|root,COG1917@2|Bacteria,1NA8I@1224|Proteobacteria 1224|Proteobacteria S PFAM Cupin 2 conserved barrel domain protein - - - - - - - - - - - - Cupin_2 GZD1_k127_3594081_26 861299.J421_1805 1.688e-38 153.0 COG1416@1|root,COG1416@2|Bacteria,1ZU3V@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3594081_3 861299.J421_1236 6.569e-254 798.0 COG0488@1|root,COG0488@2|Bacteria,1ZSV1@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn GZD1_k127_3594081_33 96561.Dole_2627 6.281e-16 90.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase crtF - - - - - - - - - - - Methyltransf_11,Methyltransf_2,Methyltransf_23 GZD1_k127_3594081_0 234267.Acid_4623 0.0 1384.0 COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria 57723|Acidobacteria S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 GZD1_k127_3594081_9 379066.GAU_1079 6.383e-164 539.0 COG1228@1|root,COG1228@2|Bacteria,1ZSME@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 GZD1_k127_3594081_25 861299.J421_1312 1.39e-39 154.0 COG2318@1|root,COG2318@2|Bacteria,1ZV4R@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 GZD1_k127_3594081_18 234267.Acid_4574 9.15e-76 261.0 COG0640@1|root,COG0640@2|Bacteria,3Y6JR@57723|Acidobacteria 57723|Acidobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - - GZD1_k127_3594081_34 1122176.KB903539_gene1307 8.834e-10 71.0 COG2834@1|root,COG2834@2|Bacteria,4NHV3@976|Bacteroidetes,1IZ7F@117747|Sphingobacteriia 976|Bacteroidetes M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - DUF4292,LolA_like GZD1_k127_3594081_20 1396858.Q666_01930 2.306e-63 222.0 COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,1RNWW@1236|Gammaproteobacteria,465H3@72275|Alteromonadaceae 1236|Gammaproteobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red GZD1_k127_3594081_17 1340493.JNIF01000003_gene1371 3.342e-86 306.0 COG1741@1|root,COG1741@2|Bacteria,3Y831@57723|Acidobacteria 57723|Acidobacteria S Pirin C-terminal cupin domain - - - - - - - - - - - - Pirin,Pirin_C GZD1_k127_3594081_14 1123508.JH636440_gene2646 3.226e-120 417.0 COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg GZD1_k127_3594081_35 1123278.KB893571_gene2225 3.193e-09 71.0 COG1577@1|root,COG1874@1|root,COG2374@1|root,COG2911@1|root,COG5492@1|root,COG1577@2|Bacteria,COG1874@2|Bacteria,COG2374@2|Bacteria,COG2911@2|Bacteria,COG5492@2|Bacteria 2|Bacteria N domain, Protein mvaK2 - 2.7.1.36,2.7.4.2,3.1.3.5,3.2.1.97 ko:K00869,ko:K00938,ko:K01081,ko:K07004,ko:K17624 ko00230,ko00240,ko00760,ko00900,ko01100,ko01110,ko01130,ko04146,map00230,map00240,map00760,map00900,map01100,map01110,map01130,map04146 M00095 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02245,R02323,R02719,R03245,R03346 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - GH101 - GHMP_kinases_C,GHMP_kinases_N,NPCBM,NPCBM_assoc GZD1_k127_3594081_11 1089550.ATTH01000001_gene237 2.441e-151 502.0 COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 GZD1_k127_3594081_10 1210884.HG799464_gene10982 5.294e-163 526.0 COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes 203682|Planctomycetes J Exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL GZD1_k127_3594081_4 861299.J421_1944 5.592e-224 709.0 COG0659@1|root,COG0659@2|Bacteria,1ZTYW@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - Sulfate_transp GZD1_k127_3594081_22 1429916.X566_21020 5.718e-58 211.0 COG0652@1|root,COG0652@2|Bacteria 2|Bacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase GZD1_k127_3594081_15 1340493.JNIF01000003_gene2921 2.395e-99 331.0 COG2326@1|root,COG2326@2|Bacteria,3Y44F@57723|Acidobacteria 57723|Acidobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 GZD1_k127_3594081_29 861299.J421_3696 3.086e-28 115.0 COG0361@1|root,COG0361@2|Bacteria,1ZV5Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex - - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a GZD1_k127_3594081_2 861299.J421_4054 2.547e-298 929.0 COG3590@1|root,COG3590@2|Bacteria 2|Bacteria O peptidase - - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N GZD1_k127_3594081_6 886293.Sinac_0988 4.94e-192 610.0 COG0531@1|root,COG0531@2|Bacteria,2IX7G@203682|Planctomycetes 203682|Planctomycetes E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GZD1_k127_3594081_19 446466.Cfla_2770 2.6e-64 238.0 COG1540@1|root,COG1540@2|Bacteria,2GJA1@201174|Actinobacteria,4F1A0@85016|Cellulomonadaceae 201174|Actinobacteria S Belongs to the UPF0271 (lamB) family ycsF - - ko:K07160 - - - - ko00000 - - - LamB_YcsF GZD1_k127_3594081_24 529709.PYCH_17200 1.922e-47 188.0 COG2049@1|root,arCOG05809@2157|Archaea,2XTY2@28890|Euryarchaeota,245C1@183968|Thermococci 183968|Thermococci E Pfam:AHS1 - - - - - - - - - - - - CT_C_D GZD1_k127_3594081_23 498761.HM1_0871 2.026e-55 204.0 COG1984@1|root,COG1984@2|Bacteria,1TR6U@1239|Firmicutes,2485K@186801|Clostridia 186801|Clostridia E Allophanate hydrolase subunit 2 kipA - - ko:K06350 - - - - ko00000 - - - CT_A_B GZD1_k127_3594081_36 378806.STAUR_5295 6.52e-09 66.0 COG0810@1|root,COG0810@2|Bacteria,1NDQZ@1224|Proteobacteria,42VIY@68525|delta/epsilon subdivisions,2WRTC@28221|Deltaproteobacteria,2Z1BM@29|Myxococcales 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C GZD1_k127_3594081_31 861299.J421_3995 1.076e-23 102.0 2DING@1|root,303QG@2|Bacteria,1ZV8G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG GZD1_k127_3594081_12 342113.DM82_3533 9.068e-125 411.0 COG3511@1|root,COG3511@2|Bacteria,1R78F@1224|Proteobacteria,2VXFB@28216|Betaproteobacteria,1KHWW@119060|Burkholderiaceae 28216|Betaproteobacteria M Phosphoesterase family - - - - - - - - - - - - Phosphoesterase GZD1_k127_3594081_28 1211815.CBYP010000073_gene3624 9.402e-31 126.0 COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4ET19@85013|Frankiales 201174|Actinobacteria S Uncharacterized conserved protein (DUF2277) - - - - - - - - - - - - DUF2277 GZD1_k127_3594081_30 861299.J421_6094 4.671e-25 108.0 COG2173@1|root,COG2173@2|Bacteria 2|Bacteria M zinc D-Ala-D-Ala carboxypeptidase activity ddpX - 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Beta-lactamase,Peptidase_M15 GZD1_k127_3594081_16 861299.J421_1927 2.598e-94 323.0 COG0845@1|root,COG0845@2|Bacteria,1ZUDM@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 GZD1_k127_3594081_1 861299.J421_1928 0.0 1267.0 COG0841@1|root,COG0841@2|Bacteria,1ZUMV@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MMPL family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran GZD1_k127_3594081_13 861299.J421_1929 1.257e-120 412.0 COG1538@1|root,COG1538@2|Bacteria,1ZUTU@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP GZD1_k127_3594081_7 379066.GAU_3156 2.308e-179 578.0 COG2382@1|root,COG2382@2|Bacteria,1ZUJ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes P esterase - - - - - - - - - - - - Esterase GZD1_k127_3594081_21 246197.MXAN_4747 3.598e-60 228.0 COG3193@1|root,COG3193@2|Bacteria,1QX6Y@1224|Proteobacteria,43BZP@68525|delta/epsilon subdivisions,2X7AG@28221|Deltaproteobacteria,2YU0D@29|Myxococcales 28221|Deltaproteobacteria S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD_RagB GZD1_k127_3594081_5 215803.DB30_4033 5.193e-212 694.0 COG1629@1|root,COG4771@2|Bacteria,1QX6X@1224|Proteobacteria,43BZN@68525|delta/epsilon subdivisions,2X7AF@28221|Deltaproteobacteria,2Z3EM@29|Myxococcales 28221|Deltaproteobacteria M CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug GZD1_k127_3594081_8 880073.Calab_1764 5.268e-166 552.0 COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria 2|Bacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg GZD1_k127_3594081_27 861299.J421_1312 1.038e-35 139.0 COG2318@1|root,COG2318@2|Bacteria,1ZV4R@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 GZD1_k127_3717035_7 379066.GAU_0010 1.092e-218 694.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1ZTCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 GZD1_k127_3717035_72 861299.J421_1152 1.765e-23 105.0 COG4968@1|root,COG4968@2|Bacteria,1ZTWU@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl GZD1_k127_3717035_76 861299.J421_1153 1.651e-18 98.0 2CIIM@1|root,348GD@2|Bacteria,1ZU31@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3717035_28 1267534.KB906759_gene1822 6.27e-112 389.0 COG2409@1|root,COG2409@2|Bacteria 2|Bacteria D Drug exporters of the RND superfamily mmpL3 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - ko:K06994,ko:K07003,ko:K20466,ko:K20470 - - - - ko00000,ko02000 2.A.6.5.5,2.A.6.5.6 - - MMPL GZD1_k127_3717035_63 861299.J421_2118 2.894e-33 139.0 COG5549@1|root,COG5549@2|Bacteria,1ZTQC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Matrixin - - - - - - - - - - - - Peptidase_M10 GZD1_k127_3717035_20 671143.DAMO_2498 5.254e-140 454.0 COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria 2|Bacteria O Radical SAM superfamily pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM GZD1_k127_3717035_40 861299.J421_5865 3.204e-79 279.0 COG1680@1|root,COG1680@2|Bacteria,1ZTCC@142182|Gemmatimonadetes 2|Bacteria V Beta-lactamase nagA - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C GZD1_k127_3717035_64 1379270.AUXF01000001_gene2407 1.742e-32 134.0 COG2151@1|root,COG2151@2|Bacteria,1ZTUD@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulfur cluster assembly protein - - - - - - - - - - - - FeS_assembly_P GZD1_k127_3717035_33 861299.J421_2109 1.035e-104 353.0 COG0349@1|root,COG0349@2|Bacteria,1ZSPS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J 3'-5' exonuclease - - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC GZD1_k127_3717035_66 272560.BPSS1191 2.447e-30 132.0 COG2515@1|root,COG2515@2|Bacteria 2|Bacteria E 1-aminocyclopropane-1-carboxylate deaminase activity dcyD - 3.5.99.7,4.4.1.15 ko:K01505,ko:K05396 ko00270,map00270 - R00997,R01874 RC00382,RC00419 ko00000,ko00001,ko01000 - - - PALP GZD1_k127_3717035_53 1379270.AUXF01000001_gene2403 1.845e-54 201.0 COG0596@1|root,COG0596@2|Bacteria,1ZU90@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Ndr family - - - - - - - - - - - - Abhydrolase_1 GZD1_k127_3717035_57 379066.GAU_3022 8.798e-46 166.0 COG1146@1|root,COG1146@2|Bacteria,1ZU19@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 GZD1_k127_3717035_79 1122247.C731_0300 1.276e-10 67.0 COG1309@1|root,COG1309@2|Bacteria,2H131@201174|Actinobacteria,232TI@1762|Mycobacteriaceae 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_6,TetR_N GZD1_k127_3717035_67 379066.GAU_0857 6.309e-30 123.0 COG0515@1|root,COG0515@2|Bacteria,1ZT5R@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_3717035_9 886293.Sinac_6682 9.811e-196 619.0 COG0422@1|root,COG0422@2|Bacteria,2IWV7@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM GZD1_k127_3717035_11 251221.35210640 2.498e-182 616.0 COG0383@1|root,COG0383@2|Bacteria,1G1RB@1117|Cyanobacteria 1117|Cyanobacteria G PFAM Glycosyl hydrolases family 38 C-terminal domain ams1 - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C GZD1_k127_3717035_65 1340493.JNIF01000003_gene2956 5.547e-31 137.0 COG0242@1|root,COG0242@2|Bacteria 2|Bacteria J peptide deformylase activity - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - HTH_31,Pep_deformylase GZD1_k127_3717035_73 316067.Geob_0102 1.053e-22 105.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,42SCH@68525|delta/epsilon subdivisions,2WPMA@28221|Deltaproteobacteria,43SR2@69541|Desulfuromonadales 28221|Deltaproteobacteria S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 GZD1_k127_3717035_3 1303518.CCALI_00609 5.131e-254 788.0 COG0719@1|root,COG0719@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly sufB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - ko:K07033,ko:K09014 - - - - ko00000 - - iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078 UPF0051 GZD1_k127_3717035_31 379066.GAU_3028 3.545e-107 361.0 COG0396@1|root,COG0396@2|Bacteria,1ZSRX@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ABC transporter sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran GZD1_k127_3717035_38 234267.Acid_7701 7.194e-88 308.0 COG0719@1|root,COG0719@2|Bacteria,3Y4EK@57723|Acidobacteria 57723|Acidobacteria O Uncharacterized protein family (UPF0051) - - - ko:K09015 - - - - ko00000 - - - UPF0051 GZD1_k127_3717035_12 671143.DAMO_2380 1.898e-174 560.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 GZD1_k127_3717035_55 1121127.JAFA01000009_gene6890 1.074e-49 181.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ3A@28216|Betaproteobacteria,1K7JP@119060|Burkholderiaceae 28216|Betaproteobacteria C NifU-like N terminal domain - - - ko:K04488 - - - - ko00000 - - - NifU_N GZD1_k127_3717035_30 1234364.AMSF01000024_gene3768 1.857e-108 361.0 COG4152@1|root,COG4152@2|Bacteria,1QUPV@1224|Proteobacteria,1T47Q@1236|Gammaproteobacteria,1XD8K@135614|Xanthomonadales 135614|Xanthomonadales S ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_3717035_42 1234364.AMSF01000024_gene3767 6.436e-77 277.0 COG1668@1|root,COG1668@2|Bacteria,1R62N@1224|Proteobacteria 1224|Proteobacteria CP COG1668 ABC-type Na efflux pump, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 GZD1_k127_3717035_77 1189612.A33Q_2703 3.712e-16 83.0 COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,47YAS@768503|Cytophagia 976|Bacteroidetes M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP GZD1_k127_3717035_10 713586.KB900536_gene2134 3.987e-186 600.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales 135613|Chromatiales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc GZD1_k127_3717035_32 861299.J421_1165 1.165e-106 352.0 COG1192@1|root,COG1192@2|Bacteria,1ZTH2@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 GZD1_k127_3717035_39 861299.J421_1167 3.444e-85 293.0 COG1475@1|root,COG1475@2|Bacteria,1ZSKT@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc GZD1_k127_3717035_70 858215.Thexy_1642 4.522e-26 120.0 COG4942@1|root,COG4942@2|Bacteria,1VJ3D@1239|Firmicutes,25ERZ@186801|Clostridia,42JGR@68295|Thermoanaerobacterales 186801|Clostridia D PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 GZD1_k127_3717035_78 1189612.A33Q_4341 8.643e-12 72.0 COG1664@1|root,COG1664@2|Bacteria,4NUZA@976|Bacteroidetes,47SCM@768503|Cytophagia 976|Bacteroidetes M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin GZD1_k127_3717035_46 497964.CfE428DRAFT_0749 3.335e-72 251.0 COG0327@1|root,COG0327@2|Bacteria 2|Bacteria L Belongs to the GTP cyclohydrolase I type 2 NIF3 family ybgI GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - NIF3 GZD1_k127_3717035_29 797114.C475_19128 7.497e-110 370.0 COG0477@1|root,arCOG00130@2157|Archaea,2XT8X@28890|Euryarchaeota,23TJU@183963|Halobacteria 183963|Halobacteria G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 GZD1_k127_3717035_35 861299.J421_0510 2.775e-103 348.0 COG2220@1|root,COG2220@2|Bacteria,1ZUY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 GZD1_k127_3717035_45 1123242.JH636434_gene4813 2.029e-73 260.0 COG1600@1|root,COG1600@2|Bacteria,2IX4H@203682|Planctomycetes 203682|Planctomycetes C Fe-S protein - - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16,HEAT_2 GZD1_k127_3717035_68 861299.J421_2311 6.029e-28 115.0 2FKCY@1|root,34C0C@2|Bacteria,1ZU3I@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3717035_27 1382306.JNIM01000001_gene1964 3.603e-115 386.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine ycbU - - - - - - - - - - - Aminotran_5 GZD1_k127_3717035_37 379066.GAU_2861 4.041e-93 313.0 COG1611@1|root,COG1611@2|Bacteria,1ZT7E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox GZD1_k127_3717035_16 251221.35211608 1.54e-156 512.0 COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the deoxyhypusine synthase family - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS GZD1_k127_3717035_52 1382306.JNIM01000001_gene1070 4.065e-55 212.0 COG2271@1|root,COG2271@2|Bacteria 2|Bacteria G transmembrane transporter activity - - - - - - - - - - - - MFS_1 GZD1_k127_3717035_82 1278073.MYSTI_02552 9.611e-10 72.0 COG2214@1|root,COG2214@2|Bacteria,1PJXA@1224|Proteobacteria,433Y7@68525|delta/epsilon subdivisions,2X41U@28221|Deltaproteobacteria,2YXZY@29|Myxococcales 28221|Deltaproteobacteria O DnaJ molecular chaperone homology domain - - - - - - - - - - - - - GZD1_k127_3717035_86 420324.KI911956_gene3392 0.0001457 55.0 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2TRR9@28211|Alphaproteobacteria,1JR6J@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 GZD1_k127_3717035_69 1379270.AUXF01000001_gene2004 5.8e-27 121.0 COG3137@1|root,COG3137@2|Bacteria,1ZUTC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 GZD1_k127_3717035_49 84531.JMTZ01000040_gene587 1.463e-69 244.0 COG4760@1|root,COG4760@2|Bacteria,1RDFF@1224|Proteobacteria,1T1EG@1236|Gammaproteobacteria,1X434@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - BaxI_1 GZD1_k127_3717035_60 379066.GAU_0986 6.919e-39 167.0 COG1413@1|root,COG1413@2|Bacteria,1ZUDH@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeat - - - - - - - - - - - - HEAT_2 GZD1_k127_3717035_17 483219.LILAB_09765 4.481e-149 494.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,2YTWC@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C GZD1_k127_3717035_15 379066.GAU_2857 3.23e-160 515.0 COG0183@1|root,COG0183@2|Bacteria,1ZSW1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N GZD1_k127_3717035_8 1278073.MYSTI_05936 5.584e-218 707.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria,2YU7W@29|Myxococcales 28221|Deltaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 GZD1_k127_3717035_25 861299.J421_4533 6.359e-117 384.0 COG0506@1|root,COG0506@2|Bacteria,1ZT6A@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh GZD1_k127_3717035_43 1379270.AUXF01000001_gene2472 1.095e-74 264.0 COG1162@1|root,COG1162@2|Bacteria,1ZSSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase GZD1_k127_3717035_61 1379270.AUXF01000001_gene2089 5.073e-38 146.0 COG1694@1|root,COG1694@2|Bacteria 2|Bacteria FG Mazg nucleotide pyrophosphohydrolase ypjD - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - MazG GZD1_k127_3717035_50 502025.Hoch_4921 3.644e-67 244.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2Z31V@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 GZD1_k127_3717035_80 1379270.AUXF01000001_gene2507 5.097e-10 70.0 2FCBU@1|root,344FF@2|Bacteria,1ZU39@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3717035_14 861299.J421_4478 1.322e-167 547.0 COG1574@1|root,COG1574@2|Bacteria,1ZU9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 GZD1_k127_3717035_88 118173.KB235910_gene4409 0.0005632 52.0 COG0457@1|root,COG0457@2|Bacteria,1GQEI@1117|Cyanobacteria,1HI2Q@1150|Oscillatoriales 1117|Cyanobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_6,TPR_8 GZD1_k127_3717035_47 861299.J421_0555 1.62e-71 262.0 COG0793@1|root,COG0793@2|Bacteria,1ZT92@142182|Gemmatimonadetes 2|Bacteria M tail specific protease prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 GZD1_k127_3717035_1 379066.GAU_2797 0.0 1019.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C GZD1_k127_3717035_26 1379270.AUXF01000001_gene2554 1.017e-116 398.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_3717035_6 269799.Gmet_3214 1.314e-227 730.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,43T3K@69541|Desulfuromonadales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C GZD1_k127_3717035_75 1231391.AMZF01000014_gene2327 2.648e-19 95.0 COG1309@1|root,COG1309@2|Bacteria,1R5AI@1224|Proteobacteria,2VH3Y@28216|Betaproteobacteria,3T51T@506|Alcaligenaceae 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N GZD1_k127_3717035_62 1384054.N790_07260 3.895e-34 149.0 COG2267@1|root,COG2267@2|Bacteria,1P3EB@1224|Proteobacteria,1T1US@1236|Gammaproteobacteria,1XDDZ@135614|Xanthomonadales 135614|Xanthomonadales I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 GZD1_k127_3717035_81 588932.JHOF01000018_gene1037 6.076e-10 68.0 COG1378@1|root,COG1378@2|Bacteria,1N9ZU@1224|Proteobacteria,2U7Z9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Sugar-specific transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB GZD1_k127_3717035_58 379066.GAU_2771 1.158e-44 177.0 2EW3S@1|root,33PH0@2|Bacteria,1ZTQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3717035_19 1183438.GKIL_0436 8.858e-142 468.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,Peptidase_M28 GZD1_k127_3717035_5 1121920.AUAU01000023_gene2395 1.72e-237 753.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.3,4.2.1.33,4.2.1.35 ko:K01681,ko:K01703,ko:K01704,ko:K17749 ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00432,M00535,M00740 R01324,R01325,R01900,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501 RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C GZD1_k127_3717035_48 861299.J421_4336 3.572e-71 256.0 COG1306@1|root,COG1306@2|Bacteria 2|Bacteria S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 GZD1_k127_3717035_4 861299.J421_1696 1.108e-237 758.0 COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 GZD1_k127_3717035_36 694427.Palpr_1413 1.871e-98 341.0 COG2885@1|root,COG2885@2|Bacteria,4NE8J@976|Bacteroidetes 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OMP_b-brl,OmpA,TSP_3 GZD1_k127_3717035_87 8083.ENSXMAP00000003500 0.0001528 55.0 KOG4441@1|root,KOG4441@2759|Eukaryota,39D0B@33154|Opisthokonta,3BEJF@33208|Metazoa,3CTRM@33213|Bilateria,48A90@7711|Chordata,4954W@7742|Vertebrata,49U6Y@7898|Actinopterygii 33208|Metazoa T Kelch-like family member 29 KLHL29 GO:0000151,GO:0005575,GO:0005622,GO:0005623,GO:0031461,GO:0031463,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1990234 - ko:K10457,ko:K10461,ko:K10465 - - - - ko00000,ko04121 - - - BACK,BTB,Kelch_1,Kelch_6 GZD1_k127_3717035_74 649747.HMPREF0083_03219 1.448e-22 114.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26QU5@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein tlpA3 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 GZD1_k127_3717035_83 997346.HMPREF9374_0031 2.415e-09 60.0 COG3526@1|root,COG3526@2|Bacteria,1VKFI@1239|Firmicutes,4HR9S@91061|Bacilli 91061|Bacilli O Rdx family - - - ko:K07401 - - - - ko00000 - - - Rdx GZD1_k127_3717035_21 357808.RoseRS_1829 4.29e-139 451.0 COG0205@1|root,COG0205@2|Bacteria,2G6CJ@200795|Chloroflexi,374WW@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK GZD1_k127_3717035_41 1198452.Jab_1c09850 5.542e-77 293.0 COG4714@1|root,COG4714@2|Bacteria,1N40I@1224|Proteobacteria,2VNFR@28216|Betaproteobacteria,477I1@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF2167) - - - - - - - - - - - - DUF2167 GZD1_k127_3717035_2 861299.J421_4433 3.705e-321 1003.0 COG1643@1|root,COG1643@2|Bacteria,1ZSN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Atp-dependent helicase - - - - - - - - - - - - - GZD1_k127_3717035_84 318586.Pden_4264 4.607e-06 55.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2TR0H@28211|Alphaproteobacteria,2PUWS@265|Paracoccus 28211|Alphaproteobacteria KQ GAF domain acxR - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activ_2,Sigma54_activat GZD1_k127_3717035_71 861299.J421_4429 6.442e-25 110.0 COG0824@1|root,COG0824@2|Bacteria,1ZV5K@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Thioesterase superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT GZD1_k127_3717035_51 378806.STAUR_7251 1.028e-59 228.0 COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,43C12@68525|delta/epsilon subdivisions,2WXMX@28221|Deltaproteobacteria,2Z37R@29|Myxococcales 28221|Deltaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C GZD1_k127_3717035_13 861299.J421_4428 1.246e-171 546.0 COG0761@1|root,COG0761@2|Bacteria,1ZTGU@142182|Gemmatimonadetes 142182|Gemmatimonadetes C LytB protein - - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB GZD1_k127_3717035_0 748280.NH8B_2766 0.0 1635.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C GZD1_k127_3717035_44 861299.J421_5976 9.775e-74 265.0 COG1533@1|root,COG1533@2|Bacteria,1ZUFM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM GZD1_k127_3717035_85 537007.BLAHAN_05504 3.487e-05 47.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC GZD1_k127_3717035_18 1519464.HY22_09440 2.743e-146 477.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GZD1_k127_3717035_54 861299.J421_3846 2.673e-50 187.0 COG1392@1|root,COG1392@2|Bacteria,1ZTKX@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div GZD1_k127_3717035_24 379066.GAU_2373 1.453e-118 390.0 COG0306@1|root,COG0306@2|Bacteria,1ZSZ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Phosphate transporter family - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 GZD1_k127_3717035_22 357808.RoseRS_3490 9.291e-139 454.0 COG1012@1|root,COG1012@2|Bacteria,2G5NY@200795|Chloroflexi 200795|Chloroflexi C Aldehyde dehydrogenase - - - - - - - - - - - - Aldedh GZD1_k127_3717035_34 234267.Acid_1836 3.724e-104 350.0 COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria 57723|Acidobacteria E aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 GZD1_k127_3717035_56 1192034.CAP_5445 8.77e-49 195.0 COG0546@1|root,COG0546@2|Bacteria,1RBMZ@1224|Proteobacteria,42RG3@68525|delta/epsilon subdivisions,2WZ2N@28221|Deltaproteobacteria,2Z16Z@29|Myxococcales 28221|Deltaproteobacteria S HAD-hyrolase-like - - 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 GZD1_k127_3717035_59 1379270.AUXF01000001_gene2636 2.413e-43 181.0 COG0553@1|root,COG0553@2|Bacteria,1ZUB8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N GZD1_k127_3717035_23 861299.J421_4374 1.007e-121 427.0 COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1ZT3Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes LV DNA restriction-modification system - - - - - - - - - - - - N6_Mtase GZD1_k127_3724890_20 1379270.AUXF01000003_gene3875 2.766e-51 186.0 COG0691@1|root,COG0691@2|Bacteria,1ZTQN@142182|Gemmatimonadetes 142182|Gemmatimonadetes J the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB GZD1_k127_3724890_18 861299.J421_3583 9.825e-53 205.0 COG0860@1|root,COG0860@2|Bacteria,1ZSUX@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 GZD1_k127_3724890_8 861299.J421_3582 5.963e-93 321.0 COG0167@1|root,COG0167@2|Bacteria,1ZT86@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh GZD1_k127_3724890_19 754477.Q7C_2360 1.999e-51 191.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,4603F@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase GZD1_k127_3724890_25 379066.GAU_1977 1.175e-15 77.0 COG0257@1|root,COG0257@2|Bacteria,1ZVAA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L36 rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 GZD1_k127_3724890_17 861299.J421_3579 9.094e-53 189.0 COG0099@1|root,COG0099@2|Bacteria,1ZTNX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 GZD1_k127_3724890_16 379066.GAU_1975 1.481e-61 213.0 COG0100@1|root,COG0100@2|Bacteria,1ZTMZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 GZD1_k127_3724890_9 861299.J421_3577 7.08e-91 302.0 COG0522@1|root,COG0522@2|Bacteria,1ZTGJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 GZD1_k127_3724890_7 861299.J421_3576 2.33e-141 462.0 COG0202@1|root,COG0202@2|Bacteria,1ZTEV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L GZD1_k127_3724890_22 861299.J421_3575 3.095e-36 140.0 COG0203@1|root,COG0203@2|Bacteria,1ZTPM@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 GZD1_k127_3724890_24 316067.Geob_2147 6.13e-22 97.0 COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2WR85@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0003674,GO:0003735,GO:0005198 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 GZD1_k127_3724890_4 1379270.AUXF01000003_gene3886 6.357e-160 511.0 COG1089@1|root,COG1089@2|Bacteria,1ZSR1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd GZD1_k127_3724890_15 861299.J421_3572 2.66e-62 237.0 COG0451@1|root,COG0451@2|Bacteria,1ZT9D@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM Polysaccharide biosynthesis protein - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd GZD1_k127_3724890_0 861299.J421_3571 0.0 1587.0 COG0458@1|root,COG0458@2|Bacteria,1ZSPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS GZD1_k127_3724890_14 1403313.AXBR01000021_gene3169 5.19e-71 257.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,1ZC3F@1386|Bacillus 91061|Bacilli M cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - iYO844.BSU15230 FAD_binding_4,MurB_C GZD1_k127_3724890_13 279714.FuraDRAFT_3687 5.787e-74 268.0 COG0110@1|root,COG0110@2|Bacteria,1MZV9@1224|Proteobacteria,2VN51@28216|Betaproteobacteria,2KQV7@206351|Neisseriales 206351|Neisseriales S Hexapeptide repeat of succinyl-transferase - - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - Hexapep GZD1_k127_3724890_5 861299.J421_3570 1.331e-149 484.0 COG0399@1|root,COG0399@2|Bacteria,1ZT81@142182|Gemmatimonadetes 142182|Gemmatimonadetes M DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 GZD1_k127_3724890_10 1379698.RBG1_1C00001G1537 1.248e-90 316.0 COG0673@1|root,COG0673@2|Bacteria,2NP38@2323|unclassified Bacteria 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold - - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - GFO_IDH_MocA,GFO_IDH_MocA_C,Hexapep,Hexapep_2 GZD1_k127_3724890_2 861299.J421_3569 4.207e-184 589.0 COG0677@1|root,COG0677@2|Bacteria,1ZT42@142182|Gemmatimonadetes 142182|Gemmatimonadetes M UDP binding domain - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N GZD1_k127_3724890_3 861299.J421_0144 1.547e-182 586.0 COG1004@1|root,COG1004@2|Bacteria,1ZTH3@142182|Gemmatimonadetes 2|Bacteria M UDP binding domain ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N GZD1_k127_3724890_6 861299.J421_0145 7.289e-148 496.0 COG0451@1|root,COG0451@2|Bacteria,1ZUJJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd GZD1_k127_3724890_11 309807.SRU_0619 2.919e-82 288.0 COG0451@1|root,COG0451@2|Bacteria,4NEKA@976|Bacteroidetes,1FJU8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M RmlD substrate binding domain - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd GZD1_k127_3724890_27 485913.Krac_7222 3.477e-05 54.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria 485913.Krac_7222|- KLT protein kinase activity - - - - - - - - - - - - - GZD1_k127_3724890_29 232348.ADXL01000083_gene884 0.0003775 52.0 COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,1G0II@1117|Cyanobacteria,1GYS6@1129|Synechococcus 1117|Cyanobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2,TPR_1,TPR_16,TPR_2,TPR_8 GZD1_k127_3724890_23 861299.J421_3568 1.56e-31 136.0 COG4105@1|root,COG4105@2|Bacteria,1ZTMC@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane lipoprotein - - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO GZD1_k127_3724890_21 429009.Adeg_0190 2.753e-36 154.0 COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,42EM4@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like GZD1_k127_3724890_1 1379270.AUXF01000003_gene3895 0.0 1238.0 COG0653@1|root,COG0653@2|Bacteria,1ZSMK@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW GZD1_k127_3724890_12 861299.J421_3564 2.247e-77 265.0 COG2003@1|root,COG2003@2|Bacteria,1ZTFU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E RadC-like JAB domain - - - ko:K03630 - - - - ko00000 - - - RadC GZD1_k127_3833645_1 298653.Franean1_5451 5.886e-68 234.0 COG0500@1|root,COG0500@2|Bacteria,2GX4K@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_25 GZD1_k127_3833645_0 640511.BC1002_6195 9.715e-89 302.0 COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2VMB9@28216|Betaproteobacteria,1K1M2@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM intradiol ring-cleavage dioxygenase - - 1.13.11.1 ko:K03381 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R00817,R04258,R05299,R08114,R08115,R09134 RC00388,RC00535,RC01366 ko00000,ko00001,ko00002,ko01000 - - - Dioxygenase_C,Dioxygenase_N GZD1_k127_3833645_2 1123511.KB905859_gene2222 2.179e-42 158.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,4H2TB@909932|Negativicutes 909932|Negativicutes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA GZD1_k127_3886985_73 671143.DAMO_0825 0.000124 51.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein mccA GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016002,GO:0016043,GO:0016491,GO:0016667,GO:0017144,GO:0019748,GO:0020037,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044550,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070813,GO:0070814,GO:0071840,GO:0097159,GO:1901363,GO:1903136 - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1 GZD1_k127_3886985_60 1242864.D187_009505 4.36e-22 112.0 COG3303@1|root,COG3303@2|Bacteria,1MYBV@1224|Proteobacteria,42SER@68525|delta/epsilon subdivisions,2WPC2@28221|Deltaproteobacteria,2YUR5@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 GZD1_k127_3886985_56 1379698.RBG1_1C00001G1442 3.995e-27 117.0 COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family hsp - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 GZD1_k127_3886985_53 1379270.AUXF01000002_gene1476 2.041e-29 127.0 2F3M0@1|root,33WE8@2|Bacteria,1ZTTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3886985_69 747365.Thena_1035 2.526e-08 63.0 COG0607@1|root,305HX@2|Bacteria,1VPPG@1239|Firmicutes,24V0S@186801|Clostridia 186801|Clostridia P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 GZD1_k127_3886985_10 1379270.AUXF01000003_gene3360 1.657e-144 479.0 COG2217@1|root,COG2217@2|Bacteria,1ZTC7@142182|Gemmatimonadetes 2|Bacteria P E1-E2 ATPase cadA - - - - - - - - - - - E1-E2_ATPase,Hemerythrin,Hydrolase GZD1_k127_3886985_39 639030.JHVA01000001_gene3713 5.542e-55 201.0 COG2823@1|root,COG2823@2|Bacteria,3Y7T6@57723|Acidobacteria,2JN0K@204432|Acidobacteriia 204432|Acidobacteriia S bacterial OsmY and nodulation domain - - - - - - - - - - - - BON GZD1_k127_3886985_62 608538.HTH_0342 5.392e-18 94.0 COG1503@1|root,COG1503@2|Bacteria 2|Bacteria J translation release factor activity yocB GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - - GZD1_k127_3886985_67 1378168.N510_01658 4.266e-09 64.0 COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes 1239|Firmicutes S Cbs domain yhcV - - ko:K04767 - - - - ko00000 - - - CBS GZD1_k127_3886985_44 1169154.KB897788_gene860 3e-47 186.0 COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HATPase_c_2,HisKA_3 GZD1_k127_3886985_32 314345.SPV1_12687 2.13e-73 254.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria 1224|Proteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C GZD1_k127_3886985_64 1215092.PA6_028_01150 1.51e-14 81.0 COG1017@1|root,COG1017@2|Bacteria,1RI9P@1224|Proteobacteria,1S7H7@1236|Gammaproteobacteria,1YGG6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C nitric oxide dioxygenase activity - - - - - - - - - - - - - GZD1_k127_3886985_7 867903.ThesuDRAFT_01230 1.402e-170 550.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3WCWS@538999|Clostridiales incertae sedis 186801|Clostridia H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N GZD1_k127_3886985_23 234267.Acid_6224 1.87e-93 313.0 COG1024@1|root,COG1024@2|Bacteria,3Y47B@57723|Acidobacteria 57723|Acidobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 GZD1_k127_3886985_61 861299.J421_2729 5.306e-21 96.0 COG5512@1|root,COG5512@2|Bacteria,1ZTYN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 GZD1_k127_3886985_1 1379698.RBG1_1C00001G0271 1.708e-268 840.0 COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim GZD1_k127_3886985_3 1380394.JADL01000001_gene2789 1.252e-255 798.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2JPZX@204441|Rhodospirillales 204441|Rhodospirillales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn GZD1_k127_3886985_4 379066.GAU_0793 2.574e-186 599.0 COG0213@1|root,COG0213@2|Bacteria,1ZTBE@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Pyrimidine nucleoside phosphorylase C-terminal domain - - 2.4.2.2 ko:K00756 ko00240,ko01100,map00240,map01100 - R01570,R01876,R02296,R02484 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C GZD1_k127_3886985_49 861299.J421_2718 2.699e-40 161.0 COG0457@1|root,COG0457@2|Bacteria,1ZTR4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - GZD1_k127_3886985_57 246197.MXAN_4640 4.312e-25 115.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,4304I@68525|delta/epsilon subdivisions,2WVDN@28221|Deltaproteobacteria 28221|Deltaproteobacteria T sensor histidine kinase response - - - - - - - - - - - - GAF,GGDEF,HATPase_c,HisKA,Response_reg GZD1_k127_3886985_5 1304883.KI912532_gene2616 2.196e-176 577.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,2KUWJ@206389|Rhodocyclales 206389|Rhodocyclales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 GZD1_k127_3886985_63 861299.J421_2713 3.239e-16 85.0 COG1719@1|root,COG1719@2|Bacteria,1ZU65@142182|Gemmatimonadetes 142182|Gemmatimonadetes S 4-vinyl reductase, 4VR - - - - - - - - - - - - - GZD1_k127_3886985_33 552811.Dehly_0372 2.197e-71 265.0 COG0312@1|root,COG0312@2|Bacteria,2GANY@200795|Chloroflexi,34CWZ@301297|Dehalococcoidia 301297|Dehalococcoidia L Putative modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD GZD1_k127_3886985_17 552811.Dehly_0371 1.548e-119 398.0 COG0312@1|root,COG0312@2|Bacteria,2GBVJ@200795|Chloroflexi,34CYG@301297|Dehalococcoidia 301297|Dehalococcoidia S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD GZD1_k127_3886985_43 861299.J421_2712 8.565e-48 177.0 COG2236@1|root,COG2236@2|Bacteria,1ZTQ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran GZD1_k127_3886985_40 861299.J421_2711 2.482e-51 188.0 COG0457@1|root,COG0457@2|Bacteria,1ZTX0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 GZD1_k127_3886985_71 1379270.AUXF01000004_gene3093 3.147e-07 60.0 2AEY4@1|root,314VZ@2|Bacteria,1ZUUQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3886985_9 945713.IALB_1068 1.068e-144 483.0 COG1022@1|root,COG1022@2|Bacteria 2|Bacteria I Amp-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding GZD1_k127_3886985_59 861299.J421_2706 1.767e-22 106.0 2FCPE@1|root,344SN@2|Bacteria,1ZU2F@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3886985_37 861299.J421_2705 7.544e-59 223.0 COG4221@1|root,COG4221@2|Bacteria,1ZTPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S KR domain - - - - - - - - - - - - adh_short GZD1_k127_3886985_29 1379270.AUXF01000004_gene3097 1.727e-76 261.0 COG0302@1|root,COG0302@2|Bacteria,1ZT6I@142182|Gemmatimonadetes 142182|Gemmatimonadetes H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI GZD1_k127_3886985_25 1267535.KB906767_gene3097 2.696e-87 311.0 COG0530@1|root,COG0530@2|Bacteria 2|Bacteria P calcium, potassium:sodium antiporter activity - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex GZD1_k127_3886985_66 309801.trd_1490 9.625e-10 63.0 COG1917@1|root,COG1917@2|Bacteria,2G9S4@200795|Chloroflexi,27ZAD@189775|Thermomicrobia 189775|Thermomicrobia S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 GZD1_k127_3886985_22 861299.J421_2698 4.038e-103 345.0 COG0454@1|root,COG0454@2|Bacteria,1ZSVU@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 GZD1_k127_3886985_6 861299.J421_2697 3.172e-171 572.0 COG0419@1|root,COG0419@2|Bacteria,1ZTD9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - SMC_N GZD1_k127_3886985_21 861299.J421_2696 3.326e-105 354.0 COG0420@1|root,COG0420@2|Bacteria,1ZSPE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Calcineurin-like phosphoesterase superfamily domain - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos GZD1_k127_3886985_2 1379270.AUXF01000004_gene3104 1.257e-262 824.0 COG0433@1|root,COG0433@2|Bacteria,1ZURZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S COG0433 Predicted ATPase - - - ko:K06915 - - - - ko00000 - - - - GZD1_k127_3886985_54 1173263.Syn7502_00887 5.149e-29 130.0 COG2380@1|root,COG2380@2|Bacteria,1GBVK@1117|Cyanobacteria 1117|Cyanobacteria S COGs COG2380 conserved - - - - - - - - - - - - - GZD1_k127_3886985_42 867903.ThesuDRAFT_01096 1.23e-48 181.0 COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,3WDHB@538999|Clostridiales incertae sedis 186801|Clostridia S Methyltransferase domain - - - - - - - - - - - - Methyltransf_3 GZD1_k127_3886985_27 1540257.JQMW01000009_gene3540 1.065e-82 289.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DUZ@31979|Clostridiaceae 186801|Clostridia E Aminotransferase aspB - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 GZD1_k127_3886985_70 521719.ATXQ01000005_gene1500 1.702e-07 64.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1YFJQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DEADboxA,DbpA,Helicase_C GZD1_k127_3886985_65 314345.SPV1_03883 1.633e-12 72.0 297U0@1|root,2ZV0P@2|Bacteria,1P6ZH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - GZD1_k127_3886985_58 1123489.AUAN01000010_gene335 4.537e-23 104.0 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,4H539@909932|Negativicutes 909932|Negativicutes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding GZD1_k127_3886985_24 861299.J421_2688 5.364e-90 300.0 COG1435@1|root,COG1435@2|Bacteria,1ZTB2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK GZD1_k127_3886985_38 1379270.AUXF01000004_gene3113 3.834e-55 200.0 COG0237@1|root,COG0237@2|Bacteria,1ZTM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE GZD1_k127_3886985_47 379066.GAU_0764 1.632e-43 163.0 COG0509@1|root,COG0509@2|Bacteria,1ZTWD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H GZD1_k127_3886985_0 861299.J421_2685 0.0 1307.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1ZSUZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P GZD1_k127_3886985_52 861299.J421_2684 3.915e-35 155.0 COG0095@1|root,COG0095@2|Bacteria,1ZTY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Biotin/lipoate A/B protein ligase family - - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB GZD1_k127_3886985_20 861299.J421_2683 9.892e-116 392.0 COG0747@1|root,COG0747@2|Bacteria,1ZTBU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 GZD1_k127_3886985_34 861299.J421_2682 2.78e-70 250.0 COG0601@1|root,COG0601@2|Bacteria,1ZTP1@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 GZD1_k127_3886985_31 861299.J421_2681 4.434e-74 273.0 COG1173@1|root,COG1173@2|Bacteria,1ZTMP@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 GZD1_k127_3886985_15 861299.J421_2680 1.304e-122 417.0 COG0444@1|root,COG0444@2|Bacteria,1ZSWI@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY GZD1_k127_3886985_19 1379270.AUXF01000004_gene3121 1.138e-116 396.0 COG4608@1|root,COG4608@2|Bacteria,1ZSTB@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY GZD1_k127_3886985_30 379066.GAU_1080 6.351e-75 273.0 COG1234@1|root,COG1234@2|Bacteria,1ZUWE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 GZD1_k127_3886985_12 234267.Acid_0372 1.914e-124 415.0 COG3104@1|root,COG3104@2|Bacteria,3Y6W5@57723|Acidobacteria 57723|Acidobacteria E POT family - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 GZD1_k127_3886985_26 518766.Rmar_0130 1.143e-86 297.0 COG3342@1|root,COG3342@2|Bacteria,4NITT@976|Bacteroidetes 976|Bacteroidetes S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028,TPR_16,TPR_19 GZD1_k127_3886985_68 671143.DAMO_1268 9.997e-09 66.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 GZD1_k127_3886985_35 518766.Rmar_1095 8.721e-70 267.0 COG1629@1|root,COG4771@2|Bacteria,4NFJJ@976|Bacteroidetes,1FJXK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor bfeA - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_3886985_41 1303518.CCALI_01736 8.906e-49 189.0 COG2071@1|root,COG2071@2|Bacteria 2|Bacteria S gamma-glutamyl-gamma-aminobutyrate hydrolase activity - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 GZD1_k127_3886985_28 1521187.JPIM01000051_gene3470 1.54e-78 293.0 COG0745@1|root,COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg GZD1_k127_3886985_50 717231.Flexsi_0251 4.509e-40 165.0 COG0438@1|root,COG0438@2|Bacteria,2GF3X@200930|Deferribacteres 200930|Deferribacteres M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 GZD1_k127_3886985_45 861299.J421_2674 3.031e-46 186.0 COG0463@1|root,COG0463@2|Bacteria,1ZTJE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 2 - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - Glycos_transf_2 GZD1_k127_3886985_48 861299.J421_1980 1.184e-40 169.0 COG3170@1|root,COG3170@2|Bacteria,1ZTDF@142182|Gemmatimonadetes 2|Bacteria NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 GZD1_k127_3886985_14 861299.J421_2672 9.612e-123 406.0 COG1899@1|root,COG1899@2|Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - GZD1_k127_3886985_72 861299.J421_2670 2.599e-05 49.0 296V5@1|root,2ZU41@2|Bacteria,1ZU78@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3886985_36 266117.Rxyl_0462 1.042e-63 235.0 COG0665@1|root,COG0665@2|Bacteria,2GJVR@201174|Actinobacteria,4CQAU@84995|Rubrobacteria 84995|Rubrobacteria E FAD dependent oxidoreductase - - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO GZD1_k127_3886985_51 861299.J421_3108 6.216e-37 152.0 2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_3886985_16 1379270.AUXF01000004_gene3127 4.416e-122 400.0 COG0320@1|root,COG0320@2|Bacteria,1ZTA3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM GZD1_k127_3886985_18 861299.J421_2668 7.585e-117 387.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 142182|Gemmatimonadetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh GZD1_k127_3886985_8 861299.J421_2667 4.838e-152 499.0 COG0022@1|root,COG0022@2|Bacteria,1ZTA8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C GZD1_k127_3886985_11 1379270.AUXF01000004_gene3130 2.975e-132 433.0 COG0508@1|root,COG0508@2|Bacteria,1ZSYJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding GZD1_k127_3886985_13 643867.Ftrac_3319 1.1e-123 411.0 COG1249@1|root,COG1249@2|Bacteria,4NDVC@976|Bacteroidetes,47JS2@768503|Cytophagia 976|Bacteroidetes C dihydrolipoamide dehydrogenase lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim GZD1_k127_3886985_46 251221.35214989 8.835e-46 178.0 COG0321@1|root,COG0321@2|Bacteria,1G074@1117|Cyanobacteria 1117|Cyanobacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB GZD1_k127_3925162_9 1128421.JAGA01000002_gene1757 4.427e-62 228.0 COG0153@1|root,COG0153@2|Bacteria,2NNYM@2323|unclassified Bacteria 2|Bacteria G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg GZD1_k127_3925162_5 1089550.ATTH01000001_gene487 6.011e-94 325.0 COG2067@1|root,COG2067@2|Bacteria,4NFFF@976|Bacteroidetes,1FIPQ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X GZD1_k127_3925162_6 518766.Rmar_0133 5.674e-80 283.0 COG2755@1|root,COG2755@2|Bacteria,4PM67@976|Bacteroidetes,1FJ25@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - - GZD1_k127_3925162_11 1000565.METUNv1_02810 0.0002074 54.0 2FFQC@1|root,347MN@2|Bacteria,1P3GT@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - GZD1_k127_3925162_1 861299.J421_3434 2.998e-131 445.0 COG0497@1|root,COG0497@2|Bacteria,1ZSV4@142182|Gemmatimonadetes 142182|Gemmatimonadetes L May be involved in recombinational repair of damaged DNA - - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N GZD1_k127_3925162_7 861299.J421_3435 5.334e-76 278.0 COG0061@1|root,COG0061@2|Bacteria,1ZT32@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase GZD1_k127_3925162_0 861299.J421_3436 6.229e-258 811.0 COG1154@1|root,COG1154@2|Bacteria,1ZSP2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C GZD1_k127_3925162_8 861299.J421_3437 5.686e-75 263.0 COG0142@1|root,COG0142@2|Bacteria,1ZSR3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt GZD1_k127_3925162_10 204669.Acid345_3427 1.283e-06 53.0 COG1722@1|root,COG1722@2|Bacteria,3Y5H0@57723|Acidobacteria,2JK24@204432|Acidobacteriia 204432|Acidobacteriia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S GZD1_k127_3925162_4 379066.GAU_1869 1.952e-99 339.0 COG1570@1|root,COG1570@2|Bacteria,1ZT8T@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 GZD1_k127_3925162_2 861299.J421_3440 3.919e-107 365.0 COG0190@1|root,COG0190@2|Bacteria,1ZSVX@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C GZD1_k127_3925162_3 379066.GAU_1871 5.62e-107 349.0 COG1418@1|root,COG1418@2|Bacteria,1ZT0I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 GZD1_k127_3931821_4 1379270.AUXF01000006_gene113 1.102e-49 182.0 COG0439@1|root,COG0439@2|Bacteria,1ZTBD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 GZD1_k127_3931821_1 861299.J421_3416 1.469e-72 267.0 COG2265@1|root,COG2265@2|Bacteria,1ZSPC@142182|Gemmatimonadetes 142182|Gemmatimonadetes H tRNA (Uracil-5-)-methyltransferase - - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr GZD1_k127_3931821_5 861299.J421_3415 6.21e-33 135.0 COG4770@1|root,COG4770@2|Bacteria,1ZTVQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin-requiring enzyme - - - - - - - - - - - - Biotin_lipoyl GZD1_k127_3931821_2 379066.GAU_1778 6.109e-55 196.0 COG0102@1|root,COG0102@2|Bacteria,1ZTIS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 GZD1_k127_3931821_3 1379270.AUXF01000006_gene118 6.494e-51 188.0 COG0103@1|root,COG0103@2|Bacteria,1ZTM0@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S9/S16 rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 GZD1_k127_3931821_0 1379270.AUXF01000006_gene119 2.701e-82 278.0 COG0052@1|root,COG0052@2|Bacteria,1ZSNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S2 rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 GZD1_k127_3933861_0 530564.Psta_4594 6.257e-61 222.0 COG1216@1|root,COG1216@2|Bacteria,2J34H@203682|Planctomycetes 203682|Planctomycetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_3933861_1 1030157.AFMP01000011_gene3797 1.989e-40 166.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria,2K6AC@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl transferases group 1 - - - ko:K16703 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 GZD1_k127_3933861_2 1287276.X752_08335 3.932e-12 70.0 COG1216@1|root,COG1216@2|Bacteria,1MYH8@1224|Proteobacteria,2UDIH@28211|Alphaproteobacteria,43QHA@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 GZD1_k127_3998612_13 479433.Caci_1944 6.424e-08 62.0 2DG6U@1|root,2ZURF@2|Bacteria,2HCGM@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - GZD1_k127_3998612_11 1122939.ATUD01000009_gene3076 1.167e-14 86.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,2HENY@201174|Actinobacteria,4CQWS@84995|Rubrobacteria 84995|Rubrobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Hpt,Response_reg GZD1_k127_3998612_12 1122939.ATUD01000009_gene3064 4.576e-13 82.0 COG1413@1|root,COG1413@2|Bacteria,2IHYB@201174|Actinobacteria 201174|Actinobacteria C HEAT repeats - - - - - - - - - - - - HEAT_2 GZD1_k127_3998612_1 1146883.BLASA_1778 2.843e-143 473.0 COG1215@1|root,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria,4EVYU@85013|Frankiales 201174|Actinobacteria M glycosyl transferase - - - - - - - - - - - - Glyco_tranf_2_3 GZD1_k127_3998612_7 1382306.JNIM01000001_gene1022 1.199e-64 225.0 COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi 200795|Chloroflexi C 2Fe-2S -binding domain protein - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 GZD1_k127_3998612_0 1382306.JNIM01000001_gene1023 5.858e-298 938.0 COG1529@1|root,COG1529@2|Bacteria 2|Bacteria C xanthine dehydrogenase activity hcrA - 1.3.7.9 ko:K04108 ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220 - R05316 RC00490 ko00000,ko00001,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 GZD1_k127_3998612_4 485913.Krac_2435 2.416e-95 325.0 COG1319@1|root,COG1319@2|Bacteria 2|Bacteria C xanthine dehydrogenase activity hcrB - 1.3.7.9 ko:K04109 ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220 - R05316 RC00490 ko00000,ko00001,ko01000 - - - CO_deh_flav_C,FAD_binding_5 GZD1_k127_3998612_5 292564.Cyagr_2454 5.337e-87 303.0 COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,22S6X@167375|Cyanobium 1117|Cyanobacteria E amino acid - - - ko:K03294,ko:K13868 ko04974,map04974 - - - ko00000,ko00001,ko02000 2.A.3.2,2.A.3.8.15 - - AA_permease_2 GZD1_k127_3998612_6 861299.J421_6214 2.489e-82 284.0 2DNAS@1|root,32WH6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Phi_1 GZD1_k127_3998612_9 1282362.AEAC466_08670 2.008e-29 124.0 COG1695@1|root,COG1695@2|Bacteria,1RHSE@1224|Proteobacteria,2U1HF@28211|Alphaproteobacteria,2KGYZ@204458|Caulobacterales 204458|Caulobacterales K transcriptional regulator PadR family - - - - - - - - - - - - PadR GZD1_k127_3998612_10 1123073.KB899241_gene1794 2.455e-20 105.0 COG0265@1|root,COG0265@2|Bacteria,1PCJA@1224|Proteobacteria,1SXM8@1236|Gammaproteobacteria,1X6DM@135614|Xanthomonadales 135614|Xanthomonadales O PDZ domain - - - - - - - - - - - - PDZ_2 GZD1_k127_3998612_8 1211114.ALIP01000028_gene1447 1.471e-41 165.0 COG1595@1|root,COG1595@2|Bacteria,1QDHS@1224|Proteobacteria,1SS07@1236|Gammaproteobacteria,1X6DE@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_3998612_2 945713.IALB_0512 1.741e-126 414.0 COG1814@1|root,COG1814@2|Bacteria 2|Bacteria S cellular manganese ion homeostasis - - - - - - - - - - - - Rubrerythrin,VIT1 GZD1_k127_3998612_3 379066.GAU_0518 2.431e-117 385.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 GZD1_k127_4005880_24 861299.J421_2790 2.368e-11 63.0 COG0256@1|root,COG0256@2|Bacteria,1ZTUX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p GZD1_k127_4005880_9 861299.J421_2791 7.472e-75 259.0 COG0098@1|root,COG0098@2|Bacteria,1ZTHD@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C GZD1_k127_4005880_21 861299.J421_2792 2.24e-18 87.0 COG1841@1|root,COG1841@2|Bacteria,1ZU4E@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L30p/L7e - - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 GZD1_k127_4005880_17 1123405.AUMM01000026_gene2205 1.695e-41 157.0 COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli,26NW1@186821|Sporolactobacillaceae 91061|Bacilli J Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A GZD1_k127_4005880_2 861299.J421_2794 1.489e-171 548.0 COG0201@1|root,COG0201@2|Bacteria,1ZSYZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY GZD1_k127_4005880_15 1029824.AFID01000002_gene1691 1.279e-50 186.0 COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,1W8X1@1268|Micrococcaceae 201174|Actinobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid GZD1_k127_4005880_8 861299.J421_2796 6.767e-98 328.0 COG0024@1|root,COG0024@2|Bacteria,1ZTC1@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 GZD1_k127_4005880_26 1396418.BATQ01000125_gene5101 2.661e-05 57.0 COG0457@1|root,COG0457@2|Bacteria,46X09@74201|Verrucomicrobia,2IW9W@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_10,TPR_16,TPR_2,TPR_7,TPR_8 GZD1_k127_4005880_18 504472.Slin_3431 7.939e-28 117.0 2E3AG@1|root,32Y9Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_4005880_16 580332.Slit_0335 1.322e-43 166.0 arCOG05276@1|root,3195F@2|Bacteria,1RHZA@1224|Proteobacteria,2VSYY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_4005880_20 33876.JNXY01000005_gene8825 7.357e-19 100.0 COG0438@1|root,COG0438@2|Bacteria,2GIZG@201174|Actinobacteria,4DEPH@85008|Micromonosporales 201174|Actinobacteria M Glycosyltransferase Family 4 - - 2.4.1.337 ko:K19002 ko00561,ko01100,map00561,map01100 - R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 GZD1_k127_4005880_5 379066.GAU_0899 8.293e-137 452.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,1ZT04@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Formiminotransferase domain, N-terminal subdomain - - 2.1.2.5,4.3.1.4 ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N GZD1_k127_4005880_12 1379270.AUXF01000004_gene3006 2.265e-66 236.0 COG0483@1|root,COG0483@2|Bacteria,1ZTQA@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P GZD1_k127_4005880_6 861299.J421_2799 8.385e-136 439.0 COG0180@1|root,COG0180@2|Bacteria,1ZT3P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b GZD1_k127_4005880_10 379066.GAU_0902 1.944e-73 261.0 COG0111@1|root,COG0111@2|Bacteria,1ZUG6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh_C GZD1_k127_4005880_4 861299.J421_2803 5.729e-152 494.0 COG2805@1|root,COG2805@2|Bacteria,1ZT2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE GZD1_k127_4005880_14 861299.J421_2804 3.604e-53 205.0 COG0329@1|root,COG0329@2|Bacteria,1ZTGV@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS GZD1_k127_4005880_3 379066.GAU_0907 4.843e-170 545.0 COG0104@1|root,COG0104@2|Bacteria,1ZSNV@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt GZD1_k127_4005880_13 318586.Pden_4561 8.436e-59 220.0 COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,2U21E@28211|Alphaproteobacteria,2PWC6@265|Paracoccus 28211|Alphaproteobacteria G Glycerate kinase family glxK - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase GZD1_k127_4005880_0 880073.Calab_2803 4.442e-215 675.0 COG0423@1|root,COG0423@2|Bacteria,2NNN9@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b GZD1_k127_4005880_25 1266909.AUAG01000004_gene2082 1.155e-05 52.0 2EEMA@1|root,338F7@2|Bacteria,1NDWI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - GZD1_k127_4005880_22 944481.JAFP01000001_gene1269 5.9e-18 94.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2M76J@213113|Desulfurellales 28221|Deltaproteobacteria O CS domain hspA-1 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 GZD1_k127_4005880_23 861299.J421_2817 1.491e-14 79.0 2FC5K@1|root,3449E@2|Bacteria,1ZU4V@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4005880_11 861299.J421_2819 1.851e-71 252.0 COG0123@1|root,COG0123@2|Bacteria,1ZSKN@142182|Gemmatimonadetes 142182|Gemmatimonadetes BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl GZD1_k127_4005880_7 1379270.AUXF01000004_gene2972 8.582e-118 387.0 COG4948@1|root,COG4948@2|Bacteria,1ZSKY@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N GZD1_k127_4005880_1 861299.J421_2825 8.91e-190 614.0 COG1198@1|root,COG1198@2|Bacteria,1ZTE9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C GZD1_k127_4055165_21 204669.Acid345_2384 2.347e-136 453.0 COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia 204432|Acidobacteriia O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH GZD1_k127_4055165_34 1382306.JNIM01000001_gene3927 1.255e-98 348.0 COG1473@1|root,COG1473@2|Bacteria,2G5WT@200795|Chloroflexi 200795|Chloroflexi S Peptidase dimerisation domain protein - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 GZD1_k127_4055165_50 861299.J421_2443 2.587e-74 269.0 COG0177@1|root,COG0177@2|Bacteria,1ZT7K@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD GZD1_k127_4055165_15 1379270.AUXF01000002_gene1859 1.052e-150 496.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1ZTG4@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase alpha chain like domain - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_thumb,HHH_5 GZD1_k127_4055165_59 1379270.AUXF01000004_gene3357 1.109e-63 228.0 COG0596@1|root,COG0596@2|Bacteria,1ZTAV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Serine aminopeptidase, S33 - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_6 GZD1_k127_4055165_104 1089550.ATTH01000001_gene2148 3.557e-10 68.0 COG2968@1|root,COG2968@2|Bacteria,4P8H6@976|Bacteroidetes,1FJN4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Membrane - - - - - - - - - - - - OMP_b-brl GZD1_k127_4055165_9 290397.Adeh_3819 6.764e-170 551.0 COG4986@1|root,COG4986@2|Bacteria,1MV85@1224|Proteobacteria,42Q3M@68525|delta/epsilon subdivisions,2WK99@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 GZD1_k127_4055165_37 290397.Adeh_3820 7.123e-96 346.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42NPR@68525|delta/epsilon subdivisions,2WK7F@28221|Deltaproteobacteria 28221|Deltaproteobacteria P C-terminal AAA-associated domain - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - AAA_assoc_C,ABC_tran GZD1_k127_4055165_95 661478.OP10G_3830 8.365e-24 106.0 COG1956@1|root,COG1956@2|Bacteria 2|Bacteria T GAF domain-containing protein yebR - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 GZD1_k127_4055165_79 861299.J421_2449 2.649e-42 174.0 COG1413@1|root,COG1413@2|Bacteria,1ZTWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 GZD1_k127_4055165_22 383372.Rcas_0232 1.035e-135 441.0 COG1363@1|root,COG1363@2|Bacteria,2G5WS@200795|Chloroflexi,376QF@32061|Chloroflexia 32061|Chloroflexia G PFAM peptidase M18 aminopeptidase I - - - - - - - - - - - - Peptidase_M42 GZD1_k127_4055165_73 448385.sce9320 1.281e-48 194.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42T4H@68525|delta/epsilon subdivisions,2WPIT@28221|Deltaproteobacteria,2Z1DZ@29|Myxococcales 28221|Deltaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap GZD1_k127_4055165_6 472759.Nhal_3091 9.89e-199 639.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1WXBI@135613|Chromatiales 135613|Chromatiales S oligopeptide transporter - - - - - - - - - - - - OPT GZD1_k127_4055165_28 379066.GAU_3348 2.975e-114 391.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4055165_19 861299.J421_2577 1.099e-141 479.0 COG0436@1|root,COG0436@2|Bacteria,1ZT26@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class I and II - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 GZD1_k127_4055165_13 861299.J421_2462 2.001e-157 507.0 COG1960@1|root,COG1960@2|Bacteria,1ZT6S@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GZD1_k127_4055165_56 861299.J421_4487 1.252e-67 243.0 COG3595@1|root,COG3595@2|Bacteria,1ZTJA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative adhesin - - - - - - - - - - - - DUF4097 GZD1_k127_4055165_85 1379270.AUXF01000003_gene3372 1.634e-31 127.0 COG1188@1|root,COG1188@2|Bacteria,1ZTXI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J S4 RNA-binding domain - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 GZD1_k127_4055165_27 671143.DAMO_0982 9.808e-116 383.0 COG0535@1|root,COG0535@2|Bacteria,2NQVH@2323|unclassified Bacteria 2|Bacteria S Elongator protein 3, MiaB family, Radical SAM pqqE - - ko:K22226,ko:K22227 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM GZD1_k127_4055165_0 247490.KSU1_C0704 0.0 1314.0 COG0841@1|root,COG0841@2|Bacteria,2IY6W@203682|Planctomycetes 203682|Planctomycetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07788 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran GZD1_k127_4055165_47 880072.Desac_1403 6.162e-79 287.0 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,2MR7H@213462|Syntrophobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07799 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 GZD1_k127_4055165_53 404589.Anae109_1789 1.106e-72 265.0 COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42S0Z@68525|delta/epsilon subdivisions,2WWFY@28221|Deltaproteobacteria 28221|Deltaproteobacteria MU CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP GZD1_k127_4055165_52 861299.J421_1717 2.427e-73 254.0 COG4232@1|root,COG4232@2|Bacteria,1ZSQP@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Cytochrome C biogenesis protein transmembrane region - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbD GZD1_k127_4055165_86 861299.J421_1716 5.23e-30 134.0 COG0526@1|root,COG0526@2|Bacteria,1ZTV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA GZD1_k127_4055165_97 379066.GAU_2624 1.169e-20 94.0 COG1225@1|root,COG1225@2|Bacteria,1ZUGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Redoxin - - - - - - - - - - - - AhpC-TSA GZD1_k127_4055165_109 330084.JNYZ01000004_gene435 0.0003026 49.0 COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4E2TH@85010|Pseudonocardiales 201174|Actinobacteria O PFAM AhpC TSA family bcp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA GZD1_k127_4055165_106 1188252.AJYK01000017_gene1642 2.069e-08 66.0 2EPYS@1|root,33HJC@2|Bacteria,1QXDN@1224|Proteobacteria,1T397@1236|Gammaproteobacteria,1XYD4@135623|Vibrionales 135623|Vibrionales S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 GZD1_k127_4055165_2 379066.GAU_0558 7.923e-244 767.0 COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR,S-methyl_trans GZD1_k127_4055165_107 518766.Rmar_1532 1.829e-07 62.0 COG4244@1|root,COG4244@2|Bacteria,4PF9S@976|Bacteroidetes,1FKC3@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Membrane - - - - - - - - - - - - - GZD1_k127_4055165_101 1125863.JAFN01000001_gene2308 3.757e-16 89.0 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,42VE5@68525|delta/epsilon subdivisions,2WR8T@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the UPF0235 family - - - ko:K09131 - - - - ko00000 - - - DUF167 GZD1_k127_4055165_84 379066.GAU_0547 4.013e-33 135.0 COG0762@1|root,COG0762@2|Bacteria,1ZTUJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT GZD1_k127_4055165_76 330214.NIDE3822 3.915e-44 171.0 COG1881@1|root,COG1881@2|Bacteria 2|Bacteria S positive regulation of acetylcholine metabolic process ybcL - - ko:K06910 - - - - ko00000 - - - PBP GZD1_k127_4055165_1 945713.IALB_1242 3.262e-292 937.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria 2|Bacteria C oxoglutarate dehydrogenase (succinyl-transferring) activity sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr GZD1_k127_4055165_60 886293.Sinac_0489 1.897e-63 228.0 COG2367@1|root,COG2367@2|Bacteria 2|Bacteria V Beta-lactamase - - 3.4.11.2,3.5.2.6 ko:K01256,ko:K17836 ko00311,ko00480,ko01100,ko01130,ko01501,map00311,map00480,map01100,map01130,map01501 M00627,M00628 R00899,R04951,R06363 RC00096,RC00141,RC01499 ko00000,ko00001,ko00002,ko01000,ko01002,ko01504 - - - Beta-lactamase,Beta-lactamase2 GZD1_k127_4055165_58 379066.GAU_0206 1.047e-66 259.0 COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria,1ZUGE@142182|Gemmatimonadetes 142182|Gemmatimonadetes DNZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - Big_2,RCC1 GZD1_k127_4055165_70 861299.J421_6292 1.709e-52 189.0 COG0347@1|root,COG0347@2|Bacteria,1ZTTV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Nitrogen regulatory protein P-II - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II GZD1_k127_4055165_11 379066.GAU_1390 3.942e-163 525.0 COG0004@1|root,COG0004@2|Bacteria,1ZT74@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp GZD1_k127_4055165_7 861299.J421_2513 3.111e-195 618.0 COG4867@1|root,COG4867@2|Bacteria,1ZT0B@142182|Gemmatimonadetes 142182|Gemmatimonadetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 GZD1_k127_4055165_36 1150626.PHAMO_340086 2.662e-98 336.0 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,2JZ5A@204441|Rhodospirillales 204441|Rhodospirillales EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 GZD1_k127_4055165_100 1042156.CXIVA_04530 2.494e-17 91.0 COG1102@1|root,COG1102@2|Bacteria,1V4Q1@1239|Firmicutes,24IJ0@186801|Clostridia,36PDN@31979|Clostridiaceae 186801|Clostridia F Psort location Cytoplasmic, score - - - - - - - - - - - - Cytidylate_kin2 GZD1_k127_4055165_4 861299.J421_2518 2.155e-213 676.0 COG1239@1|root,COG1239@2|Bacteria,1ZT0R@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - - GZD1_k127_4055165_35 1267535.KB906767_gene3744 1.264e-98 357.0 COG0383@1|root,COG0383@2|Bacteria 2|Bacteria G mannose metabolic process - - - - - - - - - - - - Alpha-mann_mid,CBM-like,Glyco_hydro_38,Glyco_hydro_38C GZD1_k127_4055165_78 575540.Isop_3340 1.336e-42 170.0 COG0451@1|root,COG0451@2|Bacteria,2J2KW@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase GZD1_k127_4055165_88 379066.GAU_0596 8.642e-29 130.0 COG0354@1|root,COG0354@2|Bacteria,1ZTMX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Glycine cleavage T-protein C-terminal barrel domain - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C GZD1_k127_4055165_96 643867.Ftrac_1051 2.971e-22 108.0 COG2267@1|root,COG2267@2|Bacteria,4NZR9@976|Bacteroidetes,47UPJ@768503|Cytophagia 976|Bacteroidetes I Alpha/beta hydrolase family - - - - - - - - - - - - Hydrolase_4 GZD1_k127_4055165_24 1379270.AUXF01000004_gene3287 7.056e-121 405.0 COG0247@1|root,COG0247@2|Bacteria,1ZSTK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S binding domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG GZD1_k127_4055165_80 251221.35213641 1.056e-41 169.0 COG0277@1|root,COG0277@2|Bacteria,1G176@1117|Cyanobacteria 1117|Cyanobacteria C PFAM FAD binding domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 GZD1_k127_4055165_8 379066.GAU_0600 2.622e-171 552.0 COG0277@1|root,COG0277@2|Bacteria,1ZT11@142182|Gemmatimonadetes 142182|Gemmatimonadetes C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 GZD1_k127_4055165_18 379066.GAU_0602 4.081e-144 463.0 COG0568@1|root,COG0568@2|Bacteria,1ZSNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 GZD1_k127_4055165_46 264198.Reut_A3129 8.39e-80 286.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,1K17C@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI GZD1_k127_4055165_63 379066.GAU_0604 4.922e-58 208.0 COG2096@1|root,COG2096@2|Bacteria,1ZT4I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans GZD1_k127_4055165_25 379066.GAU_0605 2.455e-119 393.0 COG0492@1|root,COG0492@2|Bacteria,1ZSM1@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.2,1.19.1.1 ko:K21567 - - - - ko00000,ko01000 - - - Pyr_redox_2 GZD1_k127_4055165_49 204669.Acid345_4495 4.868e-75 271.0 COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria,2JIBN@204432|Acidobacteriia 204432|Acidobacteriia M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 GZD1_k127_4055165_31 861299.J421_2544 5.993e-111 386.0 COG4775@1|root,COG4775@2|Bacteria,1ZSY7@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA GZD1_k127_4055165_30 861299.J421_2545 5.379e-112 407.0 COG2911@1|root,COG2911@2|Bacteria,1ZT97@142182|Gemmatimonadetes 142182|Gemmatimonadetes S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB GZD1_k127_4055165_93 1292020.H483_0100980 2.198e-24 121.0 COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria 201174|Actinobacteria I Diacylglycerol kinase - - - - - - - - - - - - DAGK_cat GZD1_k127_4055165_33 1125863.JAFN01000001_gene2253 6.44e-100 342.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_4055165_83 1379270.AUXF01000002_gene1474 8.799e-35 140.0 COG3437@1|root,COG3437@2|Bacteria,1ZTD3@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HD domain - - - - - - - - - - - - HD,Response_reg GZD1_k127_4055165_55 861299.J421_2548 1.02e-69 248.0 COG3191@1|root,COG3191@2|Bacteria,1ZV5T@142182|Gemmatimonadetes 142182|Gemmatimonadetes EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 GZD1_k127_4055165_92 379066.GAU_0611 1.039e-26 128.0 COG0791@1|root,COG0791@2|Bacteria,1ZTVR@142182|Gemmatimonadetes 142182|Gemmatimonadetes M NlpC/P60 family - - - - - - - - - - - - NLPC_P60 GZD1_k127_4055165_69 861299.J421_2552 1.663e-54 199.0 COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD GZD1_k127_4055165_89 861299.J421_2553 1.064e-28 130.0 COG1437@1|root,COG1437@2|Bacteria 2|Bacteria F CYTH domain mtaD - 4.6.1.1 ko:K01768,ko:K05873 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH GZD1_k127_4055165_99 485916.Dtox_3772 1.094e-17 94.0 COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,262C8@186807|Peptococcaceae 186801|Clostridia I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS01470 ACPS GZD1_k127_4055165_45 1123368.AUIS01000004_gene281 2.08e-81 296.0 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Iron Permease efeU_1 - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrome_CBB3,FTR1 GZD1_k127_4055165_65 379066.GAU_0618 1.471e-55 207.0 COG0682@1|root,COG0682@2|Bacteria,1ZSYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT GZD1_k127_4055165_29 861299.J421_2560 3.338e-113 389.0 COG0533@1|root,COG0533@2|Bacteria,1ZT0P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 GZD1_k127_4055165_108 1121918.ARWE01000001_gene2316 2.405e-06 59.0 COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria,43SGW@69541|Desulfuromonadales 28221|Deltaproteobacteria S YbbR-like protein - - - - - - - - - - - - YbbR GZD1_k127_4055165_81 1379270.AUXF01000004_gene3264 9.268e-38 148.0 COG0526@1|root,COG0526@2|Bacteria,1ZTMM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA GZD1_k127_4055165_54 379066.GAU_0621 2.015e-71 248.0 COG0036@1|root,COG0036@2|Bacteria,1ZSP8@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Ribulose-phosphate 3 epimerase family - - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim GZD1_k127_4055165_103 882086.SacxiDRAFT_3405 2.134e-14 85.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4DXBC@85010|Pseudonocardiales 201174|Actinobacteria KLT serine threonine protein kinase pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase GZD1_k127_4055165_57 861299.J421_2565 1.513e-67 247.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1ZTGM@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB GZD1_k127_4055165_39 243231.GSU0588 1.188e-92 314.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria,43TNT@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG GZD1_k127_4055165_105 1229204.AMYY01000034_gene2298 1.352e-09 61.0 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2UG5I@28211|Alphaproteobacteria 28211|Alphaproteobacteria H thiamine biosynthesis protein ThiS thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS GZD1_k127_4055165_91 75379.Tint_2360 2.165e-27 121.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,2VSR5@28216|Betaproteobacteria,1KKTT@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI GZD1_k127_4055165_43 861299.J421_2566 1.454e-84 297.0 COG0223@1|root,COG0223@2|Bacteria,1ZTE5@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N GZD1_k127_4055165_74 391937.NA2_02904 3.07e-45 175.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,43IDN@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 - R00653 RC00165,RC00323 ko00000,ko00001,ko01000 - - - Pep_deformylase GZD1_k127_4055165_102 379066.GAU_0626 2.774e-15 79.0 COG1862@1|root,COG1862@2|Bacteria,1ZU5F@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Preprotein translocase subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC GZD1_k127_4055165_20 861299.J421_2569 8.68e-141 456.0 COG0343@1|root,COG0343@2|Bacteria,1ZSRS@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) - - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT GZD1_k127_4055165_32 861299.J421_2570 1.627e-110 385.0 COG0809@1|root,COG0809@2|Bacteria,1ZSV2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth GZD1_k127_4055165_16 379066.GAU_0629 1.277e-150 484.0 COG2255@1|root,COG2255@2|Bacteria,1ZT9W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N GZD1_k127_4055165_82 379066.GAU_0633 5.085e-36 147.0 COG0632@1|root,COG0632@2|Bacteria,1ZTR0@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N GZD1_k127_4055165_75 1379270.AUXF01000004_gene3248 1.461e-44 170.0 COG0817@1|root,COG0817@2|Bacteria,1ZTKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC GZD1_k127_4055165_38 1379270.AUXF01000004_gene3247 9.516e-96 319.0 COG0217@1|root,COG0217@2|Bacteria,1ZTF4@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulator - - - - - - - - - - - - Transcrip_reg GZD1_k127_4055165_71 1379270.AUXF01000004_gene3246 6.26e-52 194.0 COG0305@1|root,COG0305@2|Bacteria,1ZUU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DnaB-like helicase C terminal domain - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_C GZD1_k127_4055165_66 1125863.JAFN01000001_gene536 6.06e-55 205.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42UES@68525|delta/epsilon subdivisions,2WQD1@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM glycosyl transferase family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 GZD1_k127_4055165_5 379066.GAU_0638 2.363e-204 648.0 COG0745@1|root,COG0745@2|Bacteria,1ZTEW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg GZD1_k127_4055165_14 1379270.AUXF01000004_gene3243 2.124e-152 501.0 COG1132@1|root,COG1132@2|Bacteria,1ZT2T@142182|Gemmatimonadetes 142182|Gemmatimonadetes V ABC transporter transmembrane region - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran GZD1_k127_4055165_68 1356852.N008_03515 1.209e-54 202.0 COG0463@1|root,COG0463@2|Bacteria,4NEZP@976|Bacteroidetes,47MB5@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_4 GZD1_k127_4055165_67 319225.Plut_1801 6.698e-55 220.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups PIGA - - ko:K00713,ko:K06338 - - - - ko00000,ko01000,ko01003,ko01005 - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 GZD1_k127_4055165_94 526218.Sterm_3098 2.282e-24 115.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 GZD1_k127_4055165_64 379066.GAU_3121 3.257e-57 207.0 COG0463@1|root,COG0463@2|Bacteria,1ZV8Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 2 - - - ko:K12984 - - - - ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2 - Glycos_transf_2 GZD1_k127_4055165_77 591159.ACEZ01000090_gene7251 4.506e-44 175.0 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria 201174|Actinobacteria M PFAM Glycosyl transferase, group 1 pimB - 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 GZD1_k127_4055165_72 1288079.AUKN01000003_gene3678 1.845e-49 199.0 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria 201174|Actinobacteria M PFAM Glycosyl transferase, group 1 pimB - 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 GZD1_k127_4055165_61 1191523.MROS_1983 8.52e-60 210.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA GZD1_k127_4055165_42 861299.J421_4225 9.301e-87 304.0 COG1141@1|root,COG1752@1|root,COG1141@2|Bacteria,COG1752@2|Bacteria,1ZT7Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S single cluster domain - - - ko:K07001 - - - - ko00000 - - - Fer4_15,Patatin GZD1_k127_4055165_41 379066.GAU_0642 2.195e-90 319.0 COG0520@1|root,COG0520@2|Bacteria,1ZTDV@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 GZD1_k127_4055165_23 545693.BMQ_4811 6.119e-123 407.0 COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,4H9YV@91061|Bacilli,1ZBY9@1386|Bacillus 91061|Bacilli J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b GZD1_k127_4055165_3 379066.GAU_0644 3.479e-227 724.0 COG5009@1|root,COG5009@2|Bacteria,1ZT3R@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase GZD1_k127_4055165_48 861299.J421_2593 4.965e-76 273.0 COG0402@1|root,COG0402@2|Bacteria,1ZSMH@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Amidohydrolase family - - 3.5.4.28,3.5.4.31,3.5.4.40 ko:K12960,ko:K20810 ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110 - R09660,R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 GZD1_k127_4055165_87 292459.STH1836 1.114e-29 124.0 COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia 186801|Clostridia K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C GZD1_k127_4055165_12 861299.J421_1323 1.002e-161 518.0 COG0137@1|root,COG0137@2|Bacteria,1ZTYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Arginosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth GZD1_k127_4055165_17 379066.GAU_0155 1.313e-150 494.0 COG0165@1|root,COG0165@2|Bacteria,1ZSM0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Argininosuccinate lyase C-terminal argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 GZD1_k127_4055165_40 1379270.AUXF01000004_gene3235 2.062e-90 300.0 COG1403@1|root,COG1403@2|Bacteria,1ZTF1@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HNH nucleases - - - - - - - - - - - - HNH_5 GZD1_k127_4055165_90 861299.J421_2595 1.632e-28 124.0 2F73W@1|root,33ZJG@2|Bacteria,1ZTT7@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4055165_44 861299.J421_2596 3.029e-83 298.0 2EW4E@1|root,33PHK@2|Bacteria,1ZT53@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4055165_10 379066.GAU_0649 4.583e-166 546.0 COG2204@1|root,COG2204@2|Bacteria,1ZSW0@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_4055165_51 1379270.AUXF01000004_gene3229 1.241e-73 263.0 COG5000@1|root,COG5000@2|Bacteria,1ZTBX@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA GZD1_k127_4055165_62 861299.J421_2603 1.051e-59 227.0 COG0432@1|root,COG0432@2|Bacteria,1ZV8J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 GZD1_k127_4055165_26 861299.J421_2605 7.384e-116 389.0 COG1432@1|root,COG1432@2|Bacteria,1ZSRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH GZD1_k127_4065978_1 671143.DAMO_2906 1.755e-93 317.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K22348 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,SdrD_B,TIG,fn3_3 GZD1_k127_4065978_0 1379270.AUXF01000002_gene1586 1.692e-191 628.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1586|- KLT protein kinase activity - - - - - - - - - - - - - GZD1_k127_4065978_2 525904.Tter_2064 8.477e-09 64.0 2DBW8@1|root,2ZBF6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_410432_19 861299.J421_4475 5.765e-09 64.0 2CA9X@1|root,2ZJY8@2|Bacteria,1ZU1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_410432_16 604331.AUHY01000056_gene1312 1.871e-22 106.0 COG3011@1|root,COG3011@2|Bacteria,1WMPZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Protein of unknown function, DUF393 - - - - - - - - - - - - DUF393 GZD1_k127_410432_5 404589.Anae109_0005 9.217e-127 414.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2YU4F@29|Myxococcales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C GZD1_k127_410432_1 886293.Sinac_5836 5.297e-174 570.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2IXK8@203682|Planctomycetes 203682|Planctomycetes E Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 GZD1_k127_410432_10 518766.Rmar_0355 3.046e-55 222.0 COG1629@1|root,COG4771@2|Bacteria,4NTQD@976|Bacteroidetes 976|Bacteroidetes P TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec GZD1_k127_410432_17 555088.DealDRAFT_0430 4.171e-21 107.0 COG0697@1|root,COG0697@2|Bacteria,1TRTP@1239|Firmicutes,25CFI@186801|Clostridia 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA GZD1_k127_410432_6 1173028.ANKO01000244_gene3949 9.179e-118 388.0 COG0384@1|root,COG0384@2|Bacteria,1G2GP@1117|Cyanobacteria,1HHDU@1150|Oscillatoriales 1117|Cyanobacteria S Phenazine biosynthesis protein - - - - - - - - - - - - PhzC-PhzF GZD1_k127_410432_3 925409.KI911562_gene1813 1.879e-150 490.0 COG0665@1|root,COG0665@2|Bacteria,4NFT6@976|Bacteroidetes 976|Bacteroidetes E fad dependent oxidoreductase - - - - - - - - - - - - DAO,Rieske GZD1_k127_410432_9 861299.J421_6090 1.083e-57 209.0 COG1802@1|root,COG1802@2|Bacteria,1ZUBC@142182|Gemmatimonadetes 142182|Gemmatimonadetes K FCD - - - - - - - - - - - - FCD,GntR GZD1_k127_410432_2 861299.J421_3917 4.633e-166 536.0 COG0531@1|root,COG0531@2|Bacteria,1ZSUB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E C-terminus of AA_permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GZD1_k127_410432_8 292459.STH2612 1.566e-64 246.0 COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF4173 GZD1_k127_410432_7 460265.Mnod_1631 6.849e-70 244.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TU0N@28211|Alphaproteobacteria,1JSI3@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MA20_23565 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf GZD1_k127_410432_14 1379270.AUXF01000004_gene2925 4.874e-39 148.0 COG1846@1|root,COG1846@2|Bacteria,1ZU3J@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_34 GZD1_k127_410432_12 861299.J421_1010 1.994e-50 185.0 COG3127@1|root,COG3127@2|Bacteria,1ZU3K@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component - - - - - - - - - - - - - GZD1_k127_410432_21 1280390.CBQR020000099_gene2241 0.0001444 54.0 COG1073@1|root,COG1073@2|Bacteria,1VG6V@1239|Firmicutes,4HVRG@91061|Bacilli,272J2@186822|Paenibacillaceae 91061|Bacilli S alpha beta - - - - - - - - - - - - - GZD1_k127_410432_4 1340493.JNIF01000003_gene4409 6.223e-142 463.0 COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria 57723|Acidobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c GZD1_k127_410432_0 234267.Acid_4168 5.921e-193 612.0 COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria 57723|Acidobacteria T Response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_410432_13 1379270.AUXF01000002_gene1247 2.903e-45 170.0 COG4636@1|root,COG4636@2|Bacteria,1ZVA4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 GZD1_k127_410432_20 1278073.MYSTI_01766 1.206e-05 47.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_410432_15 452637.Oter_1828 2.375e-28 121.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_410432_11 234267.Acid_2214 3.163e-51 192.0 COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_4128127_7 945713.IALB_2907 2.051e-46 192.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_4128127_1 1379270.AUXF01000001_gene2809 3.263e-109 383.0 COG0006@1|root,COG0006@2|Bacteria,1ZSPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 GZD1_k127_4128127_9 1379270.AUXF01000001_gene2808 8.646e-33 134.0 2C9AX@1|root,33WUH@2|Bacteria,1ZTQK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4128127_4 1519464.HY22_05460 4.132e-51 187.0 COG1595@1|root,COG1595@2|Bacteria,1FDU7@1090|Chlorobi 1090|Chlorobi K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_4128127_11 861299.J421_4180 6.404e-24 112.0 COG1836@1|root,COG1836@2|Bacteria,1ZTT3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Integral membrane protein DUF92 - - - - - - - - - - - - DUF92 GZD1_k127_4128127_2 861299.J421_4181 5.645e-78 284.0 COG0644@1|root,COG0644@2|Bacteria,1ZTEM@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glucose inhibited division protein A - - 1.3.99.38 ko:K21401 - - - - ko00000,ko01000 - - - FAD_binding_3 GZD1_k127_4128127_8 379066.GAU_2588 2.39e-42 162.0 COG1853@1|root,COG1853@2|Bacteria,1ZTVB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct GZD1_k127_4128127_10 479434.Sthe_1007 7.938e-32 138.0 COG0500@1|root,COG2226@2|Bacteria,2G99K@200795|Chloroflexi 200795|Chloroflexi H PFAM Methyltransferase type 11 - - - - - - - - - - - - - GZD1_k127_4128127_6 861299.J421_4184 1.586e-46 173.0 COG2867@1|root,COG2867@2|Bacteria,1ZTVW@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc GZD1_k127_4128127_0 861299.J421_4185 1.236e-178 575.0 COG0304@1|root,COG0304@2|Bacteria,1ZTE1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt GZD1_k127_4128127_3 485913.Krac_11442 6.92e-59 216.0 COG0580@1|root,COG0580@2|Bacteria 2|Bacteria U water channel activity glpF - - ko:K02440,ko:K06188,ko:K09874 - - - - ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.12,1.A.8.2 - - MIP GZD1_k127_4128127_5 861299.J421_4190 3.782e-48 175.0 COG0755@1|root,COG0755@2|Bacteria,1ZTJG@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome C assembly protein - - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm GZD1_k127_4155211_3 1121015.N789_08235 2.118e-17 87.0 COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,1SAKR@1236|Gammaproteobacteria,1XATQ@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - - GZD1_k127_4155211_0 379066.GAU_0104 3.995e-112 375.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - - - - - - - - - - Aminotran_5 GZD1_k127_4155211_1 1379270.AUXF01000001_gene2039 1.483e-55 199.0 2AYX9@1|root,31R2Z@2|Bacteria,1ZTNZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 GZD1_k127_4155211_2 861299.J421_0688 5.321e-50 188.0 COG1670@1|root,COG1670@2|Bacteria 2|Bacteria J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins rimL - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 GZD1_k127_4231032_0 379066.GAU_3851 3.785e-15 90.0 COG1629@1|root,COG4771@2|Bacteria,1ZTA1@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg GZD1_k127_4311683_0 926550.CLDAP_36130 1.575e-66 256.0 COG0421@1|root,COG0421@2|Bacteria,2G80S@200795|Chloroflexi 200795|Chloroflexi E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - GZD1_k127_4311683_1 1121374.KB891587_gene3067 1.064e-07 58.0 COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria G deacetylase - - - - - - - - - - - - DUF3473,Polysacc_deac_1 GZD1_k127_4340077_10 861299.J421_3269 1.814e-24 105.0 COG0236@1|root,COG0236@2|Bacteria,1ZU0X@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding GZD1_k127_4340077_1 118168.MC7420_734 1.438e-150 486.0 COG0304@1|root,COG0304@2|Bacteria,1G1J5@1117|Cyanobacteria,1H7C2@1150|Oscillatoriales 1117|Cyanobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt GZD1_k127_4340077_2 1379270.AUXF01000006_gene256 1.249e-149 486.0 COG1060@1|root,COG1060@2|Bacteria,1ZSRJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM GZD1_k127_4340077_5 861299.J421_3266 7.79e-85 297.0 COG1427@1|root,COG1427@2|Bacteria,1ZT6H@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 4.2.1.151 ko:K11782 ko00130,ko01110,map00130,map01110 - R10666 RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth GZD1_k127_4340077_0 861299.J421_3265 2.071e-175 556.0 COG1060@1|root,COG1060@2|Bacteria,1ZSU1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1 ko:K11784 ko00130,ko01110,map00130,map01110 - R08588 RC02329 ko00000,ko00001,ko01000 - - - Radical_SAM GZD1_k127_4340077_8 1167006.UWK_03057 3.508e-32 133.0 COG0041@1|root,COG0041@2|Bacteria 2|Bacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18,6.3.4.13 ko:K01588,ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R07405 RC00090,RC00166,RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC GZD1_k127_4340077_7 1382356.JQMP01000004_gene629 9.92e-52 186.0 COG0245@1|root,COG0245@2|Bacteria,2G6RA@200795|Chloroflexi,27YBC@189775|Thermomicrobia 189775|Thermomicrobia H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB GZD1_k127_4340077_9 311403.Arad_0504 1.886e-29 133.0 COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria,4BC19@82115|Rhizobiaceae 28211|Alphaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT GZD1_k127_4340077_6 1128421.JAGA01000002_gene730 4.915e-71 254.0 COG0225@1|root,COG0225@2|Bacteria,2NPBE@2323|unclassified Bacteria 2|Bacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR GZD1_k127_4340077_3 861299.J421_1020 1.095e-142 488.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C GZD1_k127_4340077_4 861299.J421_3262 1.016e-124 407.0 COG4974@1|root,COG4974@2|Bacteria,1ZTAH@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase GZD1_k127_4340077_12 713586.KB900536_gene1127 1.461e-10 64.0 COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,1RN25@1236|Gammaproteobacteria,1X08A@135613|Chromatiales 135613|Chromatiales K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_4340077_11 215803.DB30_6335 3.358e-17 89.0 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,42VIG@68525|delta/epsilon subdivisions,2WS98@28221|Deltaproteobacteria,2YV93@29|Myxococcales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg GZD1_k127_4340077_13 1232437.KL662020_gene807 1.446e-09 66.0 COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,42ZGR@68525|delta/epsilon subdivisions,2WV0D@28221|Deltaproteobacteria,2MNAJ@213118|Desulfobacterales 28221|Deltaproteobacteria KT helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg GZD1_k127_4344348_6 861299.J421_2940 1.808e-131 445.0 COG0793@1|root,COG0793@2|Bacteria,1ZSUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,Peptidase_S41 GZD1_k127_4344348_22 555778.Hneap_1918 3.061e-39 157.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1WX8U@135613|Chromatiales 135613|Chromatiales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin GZD1_k127_4344348_29 861299.J421_2938 2.609e-24 106.0 COG3679@1|root,COG3679@2|Bacteria,1ZTRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Control of competence regulator ComK, YlbF/YmcA - - - - - - - - - - - - Com_YlbF GZD1_k127_4344348_21 861299.J421_2937 1.146e-47 182.0 COG2890@1|root,COG2890@2|Bacteria,1ZTQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Methyltransferase small domain - - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS GZD1_k127_4344348_5 861299.J421_2936 1.963e-136 442.0 COG0216@1|root,COG0216@2|Bacteria,1ZSNT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 GZD1_k127_4344348_27 1125863.JAFN01000001_gene1727 9.198e-26 109.0 COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2WRGA@28221|Deltaproteobacteria 28221|Deltaproteobacteria J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 GZD1_k127_4344348_16 861299.J421_2935 1.495e-61 219.0 COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding GZD1_k127_4344348_15 861299.J421_2934 3.047e-63 227.0 COG1235@1|root,COG1235@2|Bacteria,1ZTUH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 GZD1_k127_4344348_26 379066.GAU_3863 1.497e-28 132.0 COG1462@1|root,COG1462@2|Bacteria,1ZUR1@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG GZD1_k127_4344348_23 398767.Glov_1965 4.912e-37 149.0 COG0767@1|root,COG0767@2|Bacteria,1NSBS@1224|Proteobacteria,42ZGY@68525|delta/epsilon subdivisions 1224|Proteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE GZD1_k127_4344348_32 1121920.AUAU01000009_gene1873 4.89e-16 89.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_4344348_34 1049564.TevJSym_bv00040 0.0005008 51.0 COG1463@1|root,COG1463@2|Bacteria,1NP1A@1224|Proteobacteria 1224|Proteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD GZD1_k127_4344348_3 204669.Acid345_4432 4.908e-154 521.0 COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,3Y61X@57723|Acidobacteria 57723|Acidobacteria T HD domain - - - - - - - - - - - - GAF,HD_5 GZD1_k127_4344348_7 1303518.CCALI_01334 4.593e-108 357.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat yxaA - - ko:K07090 - - - - ko00000 - - - TauE GZD1_k127_4344348_31 525373.HMPREF0766_11358 1.346e-19 100.0 COG4272@1|root,COG4272@2|Bacteria,4NSD4@976|Bacteroidetes,1ITNA@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1634) - - - - - - - - - - - - DUF1634 GZD1_k127_4344348_19 1379698.RBG1_1C00001G0380 3.274e-57 219.0 COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria 2|Bacteria M Carbon-nitrogen hydrolase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase GZD1_k127_4344348_8 379066.GAU_1177 4.392e-104 350.0 COG0673@1|root,COG0673@2|Bacteria,1ZSV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Homoserine dehydrogenase, NAD binding domain - - - - - - - - - - - - GFO_IDH_MocA GZD1_k127_4344348_18 861299.J421_2928 1.747e-57 220.0 COG2385@1|root,COG2385@2|Bacteria,1ZT25@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID GZD1_k127_4344348_2 861299.J421_2927 1.597e-172 553.0 COG0621@1|root,COG0621@2|Bacteria,1ZT70@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 GZD1_k127_4344348_17 861299.J421_2925 2.849e-58 208.0 COG1666@1|root,COG1666@2|Bacteria,1ZTNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF520) - - - ko:K09767 - - - - ko00000 - - - DUF520 GZD1_k127_4344348_4 861299.J421_2922 1.765e-140 451.0 COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 GZD1_k127_4344348_12 861299.J421_2921 2.467e-71 249.0 COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 GZD1_k127_4344348_20 379066.GAU_3415 1.736e-51 201.0 COG0596@1|root,COG0596@2|Bacteria,1ZV5Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Alpha/beta hydrolase family - - - - - - - - - - - - - GZD1_k127_4344348_0 861299.J421_2920 2.563e-247 770.0 COG1012@1|root,COG1012@2|Bacteria,1ZST9@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Aldehyde dehydrogenase family - - - ko:K22187 ko00040,map00040 - R11768 RC00080 ko00000,ko00001,ko01000 - - - Aldedh GZD1_k127_4344348_30 379066.GAU_1167 7.42e-24 106.0 2FCTB@1|root,344W9@2|Bacteria,1ZU4K@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4344348_1 861299.J421_2917 6.645e-186 595.0 COG2204@1|root,COG2204@2|Bacteria,1ZT50@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_4344348_24 370438.PTH_0904 2.637e-32 132.0 COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,24MTR@186801|Clostridia,262QN@186807|Peptococcaceae 186801|Clostridia J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase GZD1_k127_4344348_10 861299.J421_2914 2.862e-79 273.0 COG1606@1|root,COG1606@2|Bacteria 2|Bacteria L tRNA processing - - - ko:K06864 - - - - ko00000 - - - Asn_synthase,NAD_synthase GZD1_k127_4344348_25 443255.SCLAV_3548 7.991e-31 126.0 COG1522@1|root,COG1522@2|Bacteria,2HA3J@201174|Actinobacteria 201174|Actinobacteria K AsnC family transcriptional regulator - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_AsnC-type GZD1_k127_4344348_14 1321778.HMPREF1982_01776 8.039e-67 245.0 COG0697@1|root,COG0697@2|Bacteria,1UZ6C@1239|Firmicutes,24GY3@186801|Clostridia 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA GZD1_k127_4344348_9 861299.J421_1666 1.106e-92 331.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4344348_13 861299.J421_2924 9.359e-68 267.0 COG4932@1|root,COG4932@2|Bacteria,1ZUFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M domain protein - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - - GZD1_k127_4344348_11 379066.GAU_0743 3.027e-78 301.0 COG4932@1|root,COG4932@2|Bacteria,1ZUFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M domain protein - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - - GZD1_k127_4461033_4 395965.Msil_0578 1.276e-10 64.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,3NBBA@45404|Beijerinckiaceae 28211|Alphaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 GZD1_k127_4461033_0 861299.J421_2775 3.678e-71 246.0 COG0088@1|root,COG0088@2|Bacteria,1ZSSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 GZD1_k127_4461033_1 861299.J421_2774 1.656e-67 236.0 COG0087@1|root,COG0087@2|Bacteria,1ZSW4@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 GZD1_k127_4461033_2 861299.J421_2773 1.774e-52 188.0 COG0051@1|root,COG0051@2|Bacteria,1ZTS9@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 GZD1_k127_4461033_3 865861.AZSU01000001_gene19 2.153e-18 84.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,36E5N@31979|Clostridiaceae 186801|Clostridia J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 GZD1_k127_4513780_0 1379270.AUXF01000003_gene3856 7.144e-71 252.0 COG1680@1|root,COG1680@2|Bacteria,1ZT58@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Beta-lactamase - - - - - - - - - - - - Beta-lactamase GZD1_k127_4513780_1 1379270.AUXF01000003_gene3855 1.518e-42 159.0 COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn GZD1_k127_45193_1 483219.LILAB_28155 1.809e-26 109.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2WXF1@28221|Deltaproteobacteria,2YU87@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red GZD1_k127_45193_0 1123508.JH636442_gene4006 0.0 1231.0 COG4447@1|root,COG4447@2|Bacteria,2J1J5@203682|Planctomycetes 203682|Planctomycetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 GZD1_k127_4523836_46 861299.J421_2825 3.267e-33 133.0 COG1198@1|root,COG1198@2|Bacteria,1ZTE9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C GZD1_k127_4523836_7 861299.J421_2826 2.994e-145 470.0 COG1915@1|root,COG1915@2|Bacteria 2|Bacteria E PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - Amidinotransf,Saccharop_dh_N GZD1_k127_4523836_40 861299.J421_2828 1.007e-45 169.0 COG0735@1|root,COG0735@2|Bacteria,1ZTN4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Ferric uptake regulator family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR GZD1_k127_4523836_36 204669.Acid345_1944 2.219e-63 229.0 COG1945@1|root,COG1945@2|Bacteria,3Y3KR@57723|Acidobacteria,2JIBD@204432|Acidobacteriia 204432|Acidobacteriia S Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) - - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC GZD1_k127_4523836_29 1379698.RBG1_1C00001G0708 2.423e-77 274.0 COG0010@1|root,COG0010@2|Bacteria,2NPGU@2323|unclassified Bacteria 2|Bacteria E Arginase family speB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase GZD1_k127_4523836_31 379066.GAU_0930 8.023e-72 251.0 COG0785@1|root,COG0785@2|Bacteria,1ZTJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome C biogenesis protein transmembrane region - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD GZD1_k127_4523836_55 1267535.KB906767_gene2789 3.608e-12 76.0 COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria 57723|Acidobacteria S Periplasmic or secreted lipoprotein - - - - - - - - - - - - - GZD1_k127_4523836_1 861299.J421_2837 3.416e-173 563.0 COG0405@1|root,COG0405@2|Bacteria,1ZT0E@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept GZD1_k127_4523836_25 379066.GAU_0935 1.298e-96 325.0 COG2103@1|root,COG2103@2|Bacteria,1ZT2A@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - - GZD1_k127_4523836_24 861299.J421_2839 1.669e-101 348.0 COG2377@1|root,COG2377@2|Bacteria,1ZSZI@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK GZD1_k127_4523836_57 546414.Deide_21350 2.271e-11 76.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity degP - 1.3.1.74 ko:K08070,ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Trypsin_2 GZD1_k127_4523836_60 1144275.COCOR_04000 5.711e-08 65.0 COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1RAHZ@1224|Proteobacteria,42UGY@68525|delta/epsilon subdivisions,2WQPI@28221|Deltaproteobacteria,2YUG9@29|Myxococcales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,GAF,GAF_2,Guanylate_cyc GZD1_k127_4523836_27 1379270.AUXF01000004_gene2956 2.427e-85 293.0 COG0631@1|root,COG0631@2|Bacteria,1ZT1X@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 GZD1_k127_4523836_21 861299.J421_4066 4.934e-102 357.0 COG0515@1|root,COG0515@2|Bacteria,1ZTGA@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4523836_44 290397.Adeh_2553 8.415e-34 144.0 COG1716@1|root,COG1716@2|Bacteria,1Q2GC@1224|Proteobacteria,4382T@68525|delta/epsilon subdivisions,2X0C6@28221|Deltaproteobacteria,2YVG7@29|Myxococcales 28221|Deltaproteobacteria T Forkhead associated domain - - - - - - - - - - - - FHA GZD1_k127_4523836_18 861299.J421_2845 3.508e-112 397.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSWP@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 GZD1_k127_4523836_53 518766.Rmar_2301 2.48e-16 94.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_4523836_34 861299.J421_2823 8.071e-65 243.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFI@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4523836_38 886293.Sinac_5721 7.674e-53 192.0 COG0663@1|root,COG0663@2|Bacteria,2IZP3@203682|Planctomycetes 203682|Planctomycetes S isoleucine patch - - - - - - - - - - - - Hexapep GZD1_k127_4523836_0 861299.J421_2847 0.0 1173.0 COG0209@1|root,COG0209@2|Bacteria,1ZSU9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN GZD1_k127_4523836_47 1382306.JNIM01000001_gene2489 6.412e-32 136.0 2C5C8@1|root,345UA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_4523836_37 1379270.AUXF01000002_gene1628 1.009e-58 230.0 29YN3@1|root,30KHK@2|Bacteria,1ZT0C@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative ABC exporter - - - - - - - - - - - - ABC_export GZD1_k127_4523836_23 1379270.AUXF01000002_gene1629 1.422e-101 336.0 COG1131@1|root,COG1131@2|Bacteria,1ZT45@142182|Gemmatimonadetes 142182|Gemmatimonadetes V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_4523836_59 1416759.AYMR01000027_gene1380 1.038e-08 62.0 COG1846@1|root,COG1846@2|Bacteria,2IIPH@201174|Actinobacteria,4FPXU@85023|Microbacteriaceae 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR GZD1_k127_4523836_19 357808.RoseRS_1950 1.135e-110 377.0 COG1574@1|root,COG1574@2|Bacteria,2G5YJ@200795|Chloroflexi,375CQ@32061|Chloroflexia 32061|Chloroflexia S PFAM Amidohydrolase 3 - - - - - - - - - - - - Amidohydro_3 GZD1_k127_4523836_6 379066.GAU_1104 1.151e-150 506.0 COG0469@1|root,COG0469@2|Bacteria,1ZSMD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Pyruvate kinase, barrel domain - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C GZD1_k127_4523836_3 379066.GAU_1107 1.244e-158 516.0 COG0191@1|root,COG0191@2|Bacteria,1ZSZE@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Fructose-bisphosphate aldolase class-II - - - - - - - - - - - - F_bP_aldolase GZD1_k127_4523836_50 1379270.AUXF01000005_gene382 1.608e-23 112.0 COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB GZD1_k127_4523836_26 1379270.AUXF01000005_gene383 9.125e-93 330.0 COG2008@1|root,COG2008@2|Bacteria,1ZT2G@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase GZD1_k127_4523836_62 388467.A19Y_2739 0.0006518 52.0 COG1310@1|root,COG1310@2|Bacteria 2|Bacteria S proteolysis - - - ko:K03665 - - - - ko00000,ko03009 - - - JAB,Prok-JAB GZD1_k127_4523836_61 1121013.P873_09660 5.215e-05 55.0 COG2373@1|root,COG4625@1|root,COG2373@2|Bacteria,COG4625@2|Bacteria,1RDX6@1224|Proteobacteria,1S53I@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM outer membrane autotransporter barrel - - - - - - - - - - - - Autotransporter GZD1_k127_4523836_48 1144275.COCOR_05180 1.621e-26 115.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg GZD1_k127_4523836_51 35754.JNYJ01000043_gene4597 6.298e-23 112.0 COG1413@1|root,COG1413@2|Bacteria,2INKI@201174|Actinobacteria,4DHQ2@85008|Micromonosporales 201174|Actinobacteria C HEAT repeat - - - - - - - - - - - - HEAT_2,HEAT_PBS GZD1_k127_4523836_8 350688.Clos_0614 1.045e-143 472.0 COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,248SW@186801|Clostridia,36WER@31979|Clostridiaceae 186801|Clostridia M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1 GZD1_k127_4523836_10 861299.J421_2881 2.461e-139 469.0 COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 GZD1_k127_4523836_52 926561.KB900617_gene2310 2.631e-17 85.0 COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,3WATQ@53433|Halanaerobiales 186801|Clostridia S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd GZD1_k127_4523836_30 1379270.AUXF01000005_gene387 3.124e-75 257.0 COG0353@1|root,COG0353@2|Bacteria,1ZTJX@142182|Gemmatimonadetes 142182|Gemmatimonadetes L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 GZD1_k127_4523836_35 861299.J421_2885 9.139e-65 226.0 COG2018@1|root,COG2018@2|Bacteria,1ZTK7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Roadblock/LC7 domain - - - - - - - - - - - - Robl_LC7 GZD1_k127_4523836_16 379066.GAU_1116 3.508e-115 374.0 COG1100@1|root,COG1100@2|Bacteria,1ZSQI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ADP-ribosylation factor family - - - ko:K06883 - - - - ko00000 - - - Arf GZD1_k127_4523836_41 1379270.AUXF01000005_gene391 1.127e-38 161.0 COG0558@1|root,COG0558@2|Bacteria,1ZSXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf GZD1_k127_4523836_13 379066.GAU_1122 4.111e-124 415.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1ZSS9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence-damaged protein - - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth GZD1_k127_4523836_42 1122221.JHVI01000016_gene1620 1.255e-38 156.0 COG2267@1|root,COG2267@2|Bacteria,1WMK4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Alpha beta hydrolase fold protein - - - - - - - - - - - - Hydrolase_4 GZD1_k127_4523836_43 379066.GAU_1123 1.303e-38 151.0 COG0576@1|root,COG0576@2|Bacteria,1ZTSJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE GZD1_k127_4523836_12 861299.J421_2890 4.256e-127 415.0 COG0484@1|root,COG0484@2|Bacteria,1ZT5T@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG GZD1_k127_4523836_33 640511.BC1002_3578 2.076e-65 249.0 COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VJ58@28216|Betaproteobacteria,1JZSP@119060|Burkholderiaceae 28216|Betaproteobacteria E alanine racemase - - 4.3.1.27 ko:K20757 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat GZD1_k127_4523836_54 1445613.JALM01000046_gene3105 2.109e-13 84.0 COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4E3WM@85010|Pseudonocardiales 201174|Actinobacteria S Glycosyltransferase family 87 - - - ko:K13671 - - - - ko00000,ko01000,ko01003 - GT87 - GT87 GZD1_k127_4523836_56 1193181.BN10_710002 1.166e-11 77.0 COG5650@1|root,COG5650@2|Bacteria,2GJBC@201174|Actinobacteria,4FFZ4@85021|Intrasporangiaceae 201174|Actinobacteria S Glycosyltransferase family 87 - - - ko:K13671 - - - - ko00000,ko01000,ko01003 - GT87 - GT87 GZD1_k127_4523836_45 1128421.JAGA01000001_gene2006 9.139e-34 133.0 COG2363@1|root,COG2363@2|Bacteria,2NRMS@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF423) ywdK - - - - - - - - - - - DUF423 GZD1_k127_4523836_49 366602.Caul_0664 1.036e-24 109.0 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria,2KGZA@204458|Caulobacterales 204458|Caulobacterales S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 GZD1_k127_4523836_39 1121920.AUAU01000018_gene1775 5.147e-47 177.0 COG2318@1|root,COG2318@2|Bacteria,3Y4HW@57723|Acidobacteria 57723|Acidobacteria S Mycothiol maleylpyruvate isomerase N-terminal domain - - - - - - - - - - - - DinB_2 GZD1_k127_4523836_2 1340493.JNIF01000003_gene4071 5.278e-165 530.0 COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 GZD1_k127_4523836_9 861299.J421_2891 1.078e-142 461.0 COG0482@1|root,COG0482@2|Bacteria,1ZST7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans GZD1_k127_4523836_17 861299.J421_2892 3.2e-113 377.0 COG1104@1|root,COG1104@2|Bacteria,1ZSXD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class-V - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 GZD1_k127_4523836_28 861299.J421_2896 7.373e-84 285.0 COG2120@1|root,COG2120@2|Bacteria,1ZTDK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GlcNAc-PI de-N-acetylase - - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L GZD1_k127_4523836_11 1379270.AUXF01000005_gene449 6.796e-138 461.0 COG0577@1|root,COG0577@2|Bacteria,1ZUCK@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_4523836_5 861299.J421_1415 1.305e-157 507.0 COG0577@1|root,COG0577@2|Bacteria,1ZUG3@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_4523836_22 861299.J421_2900 7.846e-102 347.0 COG0577@1|root,COG0577@2|Bacteria,1ZUN6@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_4523836_14 379066.GAU_1145 2.973e-117 394.0 COG0577@1|root,COG0577@2|Bacteria,1ZUU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_4523836_20 379066.GAU_1146 2.531e-108 357.0 COG1136@1|root,COG1136@2|Bacteria,1ZSKH@142182|Gemmatimonadetes 142182|Gemmatimonadetes V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_4523836_15 861299.J421_2903 8.488e-116 386.0 COG0845@1|root,COG0845@2|Bacteria,1ZSX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 GZD1_k127_4523836_58 1123511.KB905863_gene2491 4.624e-09 69.0 COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,4H2S7@909932|Negativicutes 909932|Negativicutes MU outer membrane efflux protein - - - - - - - - - - - - OEP GZD1_k127_4523836_32 861299.J421_2906 9.528e-67 248.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470,ko:K22232 ko00330,ko00562,map00330,map00562 - R01884,R11771 RC00615 ko00000,ko00001,ko01000 - - - Creatininase GZD1_k127_4523836_4 379066.GAU_1150 2.391e-158 548.0 COG5000@1|root,COG5000@2|Bacteria,1ZSZU@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c GZD1_k127_4569507_1 926566.Terro_2569 1.69e-101 339.0 COG0624@1|root,COG0624@2|Bacteria,3Y3TZ@57723|Acidobacteria,2JIUW@204432|Acidobacteriia 204432|Acidobacteriia E PFAM peptidase - - - - - - - - - - - - M20_dimer,Peptidase_M20 GZD1_k127_4569507_5 290317.Cpha266_1840 5.273e-07 61.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria 2|Bacteria O protein N-acetylglucosaminyltransferase activity - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 GZD1_k127_4569507_0 215803.DB30_2847 1.375e-135 452.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2YXGA@29|Myxococcales 28221|Deltaproteobacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N GZD1_k127_4569507_2 861299.J421_2658 9.168e-78 280.0 COG4324@1|root,COG4324@2|Bacteria,1ZT8G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative aminopeptidase - - - - - - - - - - - - Aminopep GZD1_k127_4569507_6 1379270.AUXF01000001_gene2583 0.0002811 52.0 COG2067@1|root,COG2067@2|Bacteria,1ZUT4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I long-chain fatty acid transport protein - - - - - - - - - - - - - GZD1_k127_4569507_4 861299.J421_2657 9.375e-68 252.0 COG5492@1|root,COG5492@2|Bacteria,1ZSW8@142182|Gemmatimonadetes 2|Bacteria N domain, Protein - - 3.2.1.4,3.4.17.14 ko:K01179,ko:K07260,ko:K13735 ko00500,ko00550,ko01100,ko01502,ko02020,ko05100,map00500,map00550,map01100,map01502,map02020,map05100 M00651 R06200,R11307,R11308 - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - GH5,GH9 - Big_1,Big_2,Glug,IAT_beta,Invasin_D3,LysM,Mfa_like_1,SLH GZD1_k127_4569507_3 861299.J421_1859 6.748e-72 260.0 COG0475@1|root,COG0475@2|Bacteria,1ZTBI@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger GZD1_k127_4570616_15 861299.J421_3986 5.343e-13 73.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE - - ko:K02456,ko:K02650,ko:K02655 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - ComP_DUS,N_methyl GZD1_k127_4570616_9 591158.SSMG_05999 1.354e-46 177.0 2C73B@1|root,330Z7@2|Bacteria,2IIMQ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - DUF998 GZD1_k127_4570616_3 1444711.CCJF01000004_gene2102 4.618e-126 422.0 COG2939@1|root,COG2939@2|Bacteria,2JFP4@204428|Chlamydiae 204428|Chlamydiae E Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 GZD1_k127_4570616_2 926550.CLDAP_10980 1.21e-200 636.0 COG3033@1|root,COG3033@2|Bacteria,2G7YV@200795|Chloroflexi 200795|Chloroflexi E PFAM aromatic amino acid beta-eliminating lyase threonine aldolase tpl - 4.1.99.1,4.1.99.2 ko:K01667,ko:K01668 ko00350,ko00380,map00350,map00380 - R00673,R00728 RC00209,RC00355,RC00364 ko00000,ko00001,ko01000 - - - Beta_elim_lyase GZD1_k127_4570616_13 401526.TcarDRAFT_2592 3.076e-18 92.0 COG1592@1|root,COG1853@1|root,COG1592@2|Bacteria,COG1853@2|Bacteria,1V3CX@1239|Firmicutes,4H4GR@909932|Negativicutes 909932|Negativicutes C Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct GZD1_k127_4570616_10 1536772.R70723_00285 1.092e-45 182.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,26S70@186822|Paenibacillaceae 91061|Bacilli D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 2.4.2.8,6.3.4.19 ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01132,R01229,R02142,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C GZD1_k127_4570616_4 1379270.AUXF01000005_gene655 1.269e-76 261.0 COG0634@1|root,COG0634@2|Bacteria,1ZTH7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Phosphoribosyl transferase domain - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran GZD1_k127_4570616_1 379066.GAU_1393 2.616e-246 776.0 COG0465@1|root,COG0465@2|Bacteria,1ZSRI@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 GZD1_k127_4570616_5 1123508.JH636445_gene6740 2.223e-70 256.0 COG0294@1|root,COG0294@2|Bacteria,2IYYU@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind GZD1_k127_4570616_6 861299.J421_3044 5.123e-69 259.0 COG1624@1|root,COG1624@2|Bacteria,1ZUI8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N GZD1_k127_4570616_8 1121439.dsat_2792 1.235e-48 183.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MB0W@213115|Desulfovibrionales 28221|Deltaproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N GZD1_k127_4570616_14 880073.Calab_2773 7.174e-17 89.0 COG3599@1|root,COG3599@2|Bacteria,2NQ77@2323|unclassified Bacteria 2|Bacteria D DivIVA protein gpsB GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K04074,ko:K07484 - - - - ko00000,ko03036 - - - DDE_Tnp_IS66,DivIVA GZD1_k127_4570616_0 861299.J421_3048 0.0 1064.0 COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 GZD1_k127_4570616_7 861299.J421_3049 1.324e-59 209.0 COG1734@1|root,COG1734@2|Bacteria,1ZTP9@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR GZD1_k127_4570616_11 861299.J421_3050 1.757e-39 154.0 COG0597@1|root,COG0597@2|Bacteria,1ZTWA@142182|Gemmatimonadetes 142182|Gemmatimonadetes M This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 GZD1_k127_4584140_6 323261.Noc_2977 0.0003054 47.0 COG2172@1|root,COG2172@2|Bacteria,1RKVT@1224|Proteobacteria,1SAGT@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase-like ATPase domain - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 GZD1_k127_4584140_4 861299.J421_3455 4.044e-37 153.0 COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS GZD1_k127_4584140_2 379066.GAU_1887 3.096e-57 204.0 COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like GZD1_k127_4584140_3 379066.GAU_1888 1.312e-40 166.0 COG0742@1|root,COG0742@2|Bacteria,1ZTVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Conserved hypothetical protein 95 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 GZD1_k127_4584140_0 379066.GAU_1889 7.294e-158 516.0 COG0608@1|root,COG0608@2|Bacteria,1ZTGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DHH family - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 GZD1_k127_4584140_1 667014.Thein_0035 2.356e-94 333.0 COG0358@1|root,COG0358@2|Bacteria,2GHQG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_N,zf-CHC2 GZD1_k127_4584140_5 861299.J421_3463 8.751e-21 99.0 COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr GZD1_k127_4587816_9 379066.GAU_1612 6.852e-112 365.0 COG0463@1|root,COG0463@2|Bacteria,1ZT31@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyltransferase like family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 GZD1_k127_4587816_20 861299.J421_3244 1.426e-59 216.0 COG0253@1|root,COG0253@2|Bacteria,1ZU42@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan - - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase GZD1_k127_4587816_32 1227739.Hsw_4255 4.224e-09 66.0 COG1729@1|root,COG1729@2|Bacteria,4NEM2@976|Bacteroidetes,47PPQ@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_21,TPR_6,TPR_7,TPR_8 GZD1_k127_4587816_31 880073.Calab_3490 7.31e-14 82.0 COG1254@1|root,COG1254@2|Bacteria,2NQ47@2323|unclassified Bacteria 2|Bacteria C Acylphosphatase acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Acylphosphatase GZD1_k127_4587816_19 338966.Ppro_0282 3.011e-60 216.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2WNP9@28221|Deltaproteobacteria,43T30@69541|Desulfuromonadales 28221|Deltaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc GZD1_k127_4587816_18 861299.J421_3240 2.918e-73 253.0 COG2518@1|root,COG2518@2|Bacteria,1ZTED@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT GZD1_k127_4587816_16 1379270.AUXF01000006_gene282 4.033e-95 323.0 COG0496@1|root,COG0496@2|Bacteria,1ZT6W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE GZD1_k127_4587816_27 269799.Gmet_1686 2.389e-33 138.0 COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,42TG8@68525|delta/epsilon subdivisions,2WQC2@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_4587816_23 379066.GAU_1604 1.45e-42 163.0 COG0789@1|root,COG0789@2|Bacteria,1ZTSI@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 GZD1_k127_4587816_15 861299.J421_3237 2.572e-95 336.0 COG0240@1|root,COG0240@2|Bacteria,1ZTFK@142182|Gemmatimonadetes 142182|Gemmatimonadetes I NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N GZD1_k127_4587816_24 319225.Plut_2058 4.747e-39 162.0 COG0344@1|root,COG0344@2|Bacteria,1FDRT@1090|Chlorobi 1090|Chlorobi I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf GZD1_k127_4587816_7 562970.Btus_1769 5.022e-130 437.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae 91061|Bacilli S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 GZD1_k127_4587816_6 1379270.AUXF01000006_gene287 3.434e-142 463.0 COG1625@1|root,COG1625@2|Bacteria,1ZSQ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 GZD1_k127_4587816_33 379066.GAU_0433 0.000377 53.0 COG4783@1|root,COG4783@2|Bacteria,1ZT4T@142182|Gemmatimonadetes 142182|Gemmatimonadetes S chaperone-mediated protein folding - - - - - - - - - - - - - GZD1_k127_4587816_2 215803.DB30_3143 1.394e-221 706.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2YTY6@29|Myxococcales 28221|Deltaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC GZD1_k127_4587816_29 861299.J421_2320 5.498e-18 98.0 COG4783@1|root,COG4783@2|Bacteria,1ZT4T@142182|Gemmatimonadetes 142182|Gemmatimonadetes S chaperone-mediated protein folding - - - - - - - - - - - - - GZD1_k127_4587816_13 861299.J421_3233 1.382e-102 346.0 COG1641@1|root,COG1641@2|Bacteria 2|Bacteria H Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K06898,ko:K09121 - - - - ko00000,ko01000 - - - DUF111 GZD1_k127_4587816_8 861299.J421_3232 1.104e-117 392.0 COG0498@1|root,COG0498@2|Bacteria,1ZT17@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Pyridoxal-phosphate dependent enzyme - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP GZD1_k127_4587816_3 379066.GAU_1598 3.818e-220 699.0 COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N GZD1_k127_4587816_12 379066.GAU_1597 1.173e-103 359.0 COG0728@1|root,COG0728@2|Bacteria,1ZTCM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN GZD1_k127_4587816_22 861299.J421_3229 1.424e-55 217.0 COG4365@1|root,COG4365@2|Bacteria,1ZTG0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bacillithiol biosynthesis BshC - - - ko:K22136 - - - - ko00000 - - - BshC GZD1_k127_4587816_25 519442.Huta_0552 3.224e-38 154.0 COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,23RXA@183963|Halobacteria 183963|Halobacteria S AMMECR1 domain-containing protein - - - ko:K09141 - - - - ko00000 - - - AMMECR1 GZD1_k127_4587816_28 1500890.JQNL01000001_gene2940 1.038e-29 124.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1X5XV@135614|Xanthomonadales 135614|Xanthomonadales J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase GZD1_k127_4587816_4 861299.J421_3227 2.626e-216 677.0 COG0334@1|root,COG0334@2|Bacteria,1ZSQB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N GZD1_k127_4587816_21 861299.J421_3226 3.992e-59 218.0 COG1663@1|root,COG1663@2|Bacteria,1ZTIE@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK GZD1_k127_4587816_26 1125863.JAFN01000001_gene3416 3.433e-34 143.0 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF374) - - - ko:K09778 - - - - ko00000 - - - DUF374 GZD1_k127_4587816_17 379066.GAU_1591 6.338e-82 300.0 COG0763@1|root,COG0763@2|Bacteria,1ZTAD@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB GZD1_k127_4587816_14 861299.J421_3223 9.753e-101 338.0 COG0673@1|root,COG0673@2|Bacteria,1ZTES@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA GZD1_k127_4587816_10 1379270.AUXF01000006_gene299 1.894e-105 348.0 COG1043@1|root,COG1043@2|Bacteria,1ZT7T@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep GZD1_k127_4587816_5 379066.GAU_1588 6.652e-147 478.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,1ZT4Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes IM Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ - 3.5.1.108,4.2.1.59 ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 - - - FabA,LpxC GZD1_k127_4587816_11 861299.J421_3220 9.639e-104 350.0 COG1044@1|root,COG1044@2|Bacteria,1ZSRF@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,LpxD GZD1_k127_4587816_30 379066.GAU_1586 4.171e-14 85.0 COG2825@1|root,COG2825@2|Bacteria,1ZU5E@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Outer membrane protein (OmpH-like) - - - ko:K06142 - - - - ko00000 - - - OmpH GZD1_k127_4587816_1 861299.J421_3218 8.172e-226 734.0 COG4775@1|root,COG4775@2|Bacteria,1ZT6B@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA GZD1_k127_4587816_0 429009.Adeg_1948 3.158e-309 967.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales 186801|Clostridia O Belongs to the ClpA ClpB family clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR GZD1_k127_4631693_0 379066.GAU_3156 1.263e-129 427.0 COG2382@1|root,COG2382@2|Bacteria,1ZUJ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes P esterase - - - - - - - - - - - - Esterase GZD1_k127_4631693_1 861299.J421_2423 2.578e-109 359.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 GZD1_k127_4661507_1 525904.Tter_1913 2.158e-41 159.0 COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria 2|Bacteria S Peptidase M28 ywaD - - - - - - - - - - - Peptidase_M28 GZD1_k127_4661507_2 861299.J421_4159 4.353e-18 92.0 COG1555@1|root,COG1555@2|Bacteria,1ZV96@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Helix-hairpin-helix motif - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 GZD1_k127_4661507_3 717605.Theco_2419 9.055e-11 70.0 COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli,26X94@186822|Paenibacillaceae 91061|Bacilli L DNA uptake protein and related DNA-binding proteins comEA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB GZD1_k127_4661507_0 639282.DEFDS_1109 6.007e-179 576.0 COG2804@1|root,COG2804@2|Bacteria,2GEP7@200930|Deferribacteres 200930|Deferribacteres NU General secretory system II protein E domain protein - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N GZD1_k127_4681162_24 861299.J421_1151 3.088e-111 367.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1ZTCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 GZD1_k127_4681162_80 309801.trd_1531 2.269e-40 173.0 COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,2G6NM@200795|Chloroflexi,27Z1J@189775|Thermomicrobia 189775|Thermomicrobia M Tetratricopeptide repeat - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,TPR_16 GZD1_k127_4681162_39 379066.GAU_0009 1.762e-79 282.0 2DTII@1|root,33KI8@2|Bacteria,1ZT3J@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_31 379066.GAU_0008 7.192e-100 334.0 COG0515@1|root,COG0515@2|Bacteria,1ZT9E@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4681162_65 379066.GAU_0007 3.874e-50 185.0 COG0461@1|root,COG0461@2|Bacteria,1ZTMR@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran GZD1_k127_4681162_49 1379270.AUXF01000002_gene1194 8.566e-62 239.0 COG0840@1|root,COG0840@2|Bacteria,1ZU0T@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal GZD1_k127_4681162_53 379066.GAU_0004 1.339e-58 213.0 COG2207@1|root,COG2207@2|Bacteria,1ZTPX@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 GZD1_k127_4681162_124 267747.PPA0652 2.489e-15 79.0 2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - GZD1_k127_4681162_87 290512.Paes_0269 7.669e-38 153.0 COG0744@1|root,COG0744@2|Bacteria,1FDQX@1090|Chlorobi 1090|Chlorobi M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly GZD1_k127_4681162_13 861299.J421_1072 2.863e-171 544.0 COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_3 GZD1_k127_4681162_12 379066.GAU_0001 1.115e-176 565.0 COG0593@1|root,COG0593@2|Bacteria,1ZSQ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N GZD1_k127_4681162_125 861299.J421_1070 1.308e-14 78.0 COG0230@1|root,COG0230@2|Bacteria,1ZU59@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L34 rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 GZD1_k127_4681162_127 861299.J421_1069 1.914e-14 79.0 COG0594@1|root,COG0594@2|Bacteria,1ZV89@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P GZD1_k127_4681162_113 497965.Cyan7822_4705 6.699e-25 106.0 COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,3KIEZ@43988|Cyanothece 1117|Cyanobacteria S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic GZD1_k127_4681162_22 861299.J421_1067 6.422e-113 385.0 COG0706@1|root,COG0706@2|Bacteria,1ZSKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas GZD1_k127_4681162_25 1379270.AUXF01000002_gene1185 9.485e-111 374.0 COG0486@1|root,COG0486@2|Bacteria,1ZSRA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N GZD1_k127_4681162_84 94624.Bpet2982 3.729e-38 151.0 COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2VVBQ@28216|Betaproteobacteria,3T846@506|Alcaligenaceae 28216|Betaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 GZD1_k127_4681162_75 94624.Bpet2983 4.813e-43 163.0 COG3832@1|root,COG3832@2|Bacteria,1RI3S@1224|Proteobacteria,2VVCX@28216|Betaproteobacteria,3T844@506|Alcaligenaceae 28216|Betaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 GZD1_k127_4681162_52 1123073.KB899242_gene1301 1.231e-60 218.0 298RU@1|root,3059D@2|Bacteria,1QRA7@1224|Proteobacteria,1TDHB@1236|Gammaproteobacteria,1XAQM@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - GZD1_k127_4681162_94 671143.DAMO_2649 2.271e-33 139.0 COG2154@1|root,COG2154@2|Bacteria,2NQ7C@2323|unclassified Bacteria 2|Bacteria H Pterin 4 alpha carbinolamine dehydratase phhB - 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 - R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 - - - Polyketide_cyc2,Pterin_4a GZD1_k127_4681162_79 1123242.JH636435_gene2546 9.729e-41 155.0 COG0720@1|root,COG0720@2|Bacteria,2IZMP@203682|Planctomycetes 203682|Planctomycetes H COG0720 6-pyruvoyl-tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS GZD1_k127_4681162_26 1379270.AUXF01000002_gene1184 1.102e-107 358.0 COG5504@1|root,COG5504@2|Bacteria,1ZTCN@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Zn-dependent protease - - - - - - - - - - - - - GZD1_k127_4681162_147 518766.Rmar_2301 0.0003668 53.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_4681162_86 861299.J421_0895 6.257e-38 154.0 COG0705@1|root,COG0705@2|Bacteria,1ZSWV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Rhomboid family - - - - - - - - - - - - Rhomboid GZD1_k127_4681162_29 471852.Tcur_3455 2.309e-101 342.0 COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4EI19@85012|Streptosporangiales 201174|Actinobacteria M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N GZD1_k127_4681162_11 1379270.AUXF01000002_gene1158 7.38e-181 580.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1ZTA6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EK Domain in cystathionine beta-synthase and other proteins. - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP GZD1_k127_4681162_142 530564.Psta_2496 7.881e-06 58.0 COG0810@1|root,COG0810@2|Bacteria,2J1AD@203682|Planctomycetes 203682|Planctomycetes M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C GZD1_k127_4681162_2 861299.J421_0903 7.74e-315 990.0 COG0249@1|root,COG0249@2|Bacteria,1ZST5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V GZD1_k127_4681162_117 861299.J421_0904 2.705e-21 109.0 COG1729@1|root,COG3087@1|root,COG1729@2|Bacteria,COG3087@2|Bacteria,1ZTSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR,TPR_6 GZD1_k127_4681162_56 379066.GAU_3913 1.616e-56 216.0 COG1466@1|root,COG1466@2|Bacteria,1ZSSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta GZD1_k127_4681162_146 635013.TherJR_0951 8.006e-05 51.0 COG5662@1|root,COG5662@2|Bacteria,1U216@1239|Firmicutes,25N56@186801|Clostridia,2631J@186807|Peptococcaceae 186801|Clostridia K Domain of unknown function (DUF4349) - - - - - - - - - - - - DUF4349,zf-HC2 GZD1_k127_4681162_34 861299.J421_0907 1.201e-90 304.0 COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_4681162_47 861299.J421_0908 5.487e-64 224.0 COG0494@1|root,COG0494@2|Bacteria,1ZTQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX GZD1_k127_4681162_104 309801.trd_1239 8.619e-29 124.0 COG1434@1|root,COG1434@2|Bacteria,2G996@200795|Chloroflexi,27YFA@189775|Thermomicrobia 189775|Thermomicrobia S DUF218 domain - - - - - - - - - - - - DUF218 GZD1_k127_4681162_9 861299.J421_6223 1.207e-194 639.0 COG2091@1|root,COG2091@2|Bacteria,1ZUE3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - GZD1_k127_4681162_46 861299.J421_0305 5.614e-69 243.0 COG1413@1|root,COG1413@2|Bacteria,1ZTU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 GZD1_k127_4681162_35 861299.J421_0306 2.3e-90 317.0 COG1413@1|root,COG1413@2|Bacteria,1ZTQY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 GZD1_k127_4681162_43 861299.J421_0308 4.459e-74 253.0 COG1595@1|root,COG1595@2|Bacteria,1ZTP3@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_4681162_30 861299.J421_1060 3.503e-100 331.0 COG0035@1|root,COG0035@2|Bacteria,1ZT1C@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase GZD1_k127_4681162_120 234267.Acid_5438 2.258e-18 98.0 COG1462@1|root,COG1462@2|Bacteria,3Y3KF@57723|Acidobacteria 57723|Acidobacteria M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG GZD1_k127_4681162_48 1038858.AXBA01000015_gene2058 2.802e-62 225.0 COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2U6BE@28211|Alphaproteobacteria,3F2BG@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase GZD1_k127_4681162_133 1144275.COCOR_01361 2.169e-10 68.0 COG3809@1|root,COG3809@2|Bacteria,1Q8Z4@1224|Proteobacteria,42UTF@68525|delta/epsilon subdivisions,2WXCZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - zf-TFIIB GZD1_k127_4681162_66 861299.J421_4311 2.205e-49 203.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 2|Bacteria T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C GZD1_k127_4681162_141 1121121.KB894333_gene4598 4.406e-06 51.0 2ED1A@1|root,336Y8@2|Bacteria,1VNP3@1239|Firmicutes,4HRCX@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - GZD1_k127_4681162_123 926569.ANT_21410 1.417e-16 84.0 COG2944@1|root,COG2944@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3,HTH_31 GZD1_k127_4681162_98 1123228.AUIH01000091_gene567 2.953e-30 123.0 COG4737@1|root,COG4737@2|Bacteria,1N7N5@1224|Proteobacteria,1S6BG@1236|Gammaproteobacteria,1XMEE@135619|Oceanospirillales 135619|Oceanospirillales S Cytotoxic translational repressor of toxin-antitoxin stability system - - - - - - - - - - - - RelE GZD1_k127_4681162_122 1122179.KB890491_gene4516 1.185e-17 87.0 COG0604@1|root,COG0604@2|Bacteria,4P9XC@976|Bacteroidetes,1IZQ4@117747|Sphingobacteriia 976|Bacteroidetes C Putative lumazine-binding - - - - - - - - - - - - Lumazine_bd_2 GZD1_k127_4681162_20 243365.CV_0198 6.901e-116 389.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,2KQTG@206351|Neisseriales 206351|Neisseriales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC GZD1_k127_4681162_67 667632.KB890164_gene2154 2.716e-49 181.0 COG0662@1|root,COG0662@2|Bacteria,1NG5P@1224|Proteobacteria,2WCQR@28216|Betaproteobacteria,1K8AM@119060|Burkholderiaceae 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 GZD1_k127_4681162_54 1449355.JQNR01000005_gene5856 4.931e-58 205.0 COG2606@1|root,COG2606@2|Bacteria,2IMZE@201174|Actinobacteria 201174|Actinobacteria G Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit GZD1_k127_4681162_38 204669.Acid345_2395 8.079e-80 282.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 GZD1_k127_4681162_33 342113.DM82_4729 1.604e-92 321.0 28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,1K17Y@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_4681162_115 1048834.TC41_2669 9.607e-22 103.0 COG4454@1|root,COG4454@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - SoxE GZD1_k127_4681162_135 70448.Q015P7 7.703e-08 64.0 COG0251@1|root,KOG2317@2759|Eukaryota,37T73@33090|Viridiplantae,34M2G@3041|Chlorophyta 3041|Chlorophyta J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP GZD1_k127_4681162_71 861299.J421_2364 3.088e-45 173.0 COG0723@1|root,COG0723@2|Bacteria,1ZU0N@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske GZD1_k127_4681162_91 861299.J421_2366 2.972e-35 141.0 2BWJK@1|root,3480I@2|Bacteria,1ZU2S@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_100 1379270.AUXF01000001_gene2747 3.41e-30 132.0 COG1196@1|root,COG1196@2|Bacteria,1ZU2U@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - GZD1_k127_4681162_1 1519464.HY22_12075 0.0 1161.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 GZD1_k127_4681162_64 861299.J421_0818 2.951e-51 194.0 2EFRH@1|root,339HI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_4681162_37 661478.OP10G_1682 2.999e-83 297.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - - - - - - - - - - AA_permease_2 GZD1_k127_4681162_88 1169144.KB910944_gene2322 2.123e-37 146.0 COG2259@1|root,COG2259@2|Bacteria,1V7TX@1239|Firmicutes,4HH6W@91061|Bacilli,1ZR8Z@1386|Bacillus 91061|Bacilli S DoxX mhqP - - ko:K15977 - - - - ko00000 - - - DoxX GZD1_k127_4681162_102 861299.J421_0116 6.498e-30 127.0 COG1846@1|root,COG1846@2|Bacteria,1ZTUS@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix multiple antibiotic resistance protein - - - ko:K15973 - - - - ko00000,ko03000 - - - MarR_2 GZD1_k127_4681162_140 667632.KB890165_gene2565 2.581e-06 61.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,1K03X@119060|Burkholderiaceae 28216|Betaproteobacteria O Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_41,SEC-C,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 GZD1_k127_4681162_14 1121920.AUAU01000027_gene1480 3.817e-167 555.0 COG0457@1|root,COG0457@2|Bacteria 1121920.AUAU01000027_gene1480|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_4681162_4 1205753.A989_09913 1.085e-302 945.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,1X3BC@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 GZD1_k127_4681162_69 886293.Sinac_7026 1.502e-47 186.0 COG3182@1|root,COG3182@2|Bacteria,2J03J@203682|Planctomycetes 2|Bacteria S iron-regulated membrane protein - - - ko:K03863 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001 - - - Fer2,PepSY_TM GZD1_k127_4681162_89 886293.Sinac_7277 1.141e-35 144.0 COG0694@1|root,COG0694@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly nfuA - - ko:K07400 - - - - ko00000 - - - Nfu_N,NifU GZD1_k127_4681162_21 326427.Cagg_2251 3.087e-115 386.0 COG0151@1|root,COG0151@2|Bacteria,2G7M4@200795|Chloroflexi,377MJ@32061|Chloroflexia 32061|Chloroflexia F ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp - - - - - - - - - - - - ATP-grasp_4 GZD1_k127_4681162_110 1408433.JHXV01000001_gene914 2.871e-26 123.0 29XKX@1|root,30JC5@2|Bacteria,4P6BI@976|Bacteroidetes 976|Bacteroidetes S Pfam:DUF2029 - - - - - - - - - - - - GT87 GZD1_k127_4681162_96 861299.J421_0561 9.617e-32 134.0 2CDZB@1|root,3340J@2|Bacteria,1ZU24@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_101 1382356.JQMP01000003_gene1500 3.639e-30 126.0 COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi,27Z8H@189775|Thermomicrobia 189775|Thermomicrobia K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_4681162_148 83332.Rv0444c 0.0008459 49.0 COG5343@1|root,COG5343@2|Bacteria,2I8NI@201174|Actinobacteria,235HJ@1762|Mycobacteriaceae 201174|Actinobacteria S An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor rskA GO:0000988,GO:0000989,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006417,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010608,GO:0016020,GO:0016989,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - RskA GZD1_k127_4681162_72 861299.J421_0057 6.32e-45 168.0 COG0782@1|root,COG0782@2|Bacteria,1ZTPD@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcription elongation factor, N-terminal - - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N GZD1_k127_4681162_42 886293.Sinac_6888 5.352e-75 262.0 COG0109@1|root,COG0109@2|Bacteria,2IYUU@203682|Planctomycetes 203682|Planctomycetes O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA GZD1_k127_4681162_5 861299.J421_1532 1.105e-279 876.0 COG0021@1|root,COG0021@2|Bacteria,1ZTA2@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N GZD1_k127_4681162_19 379066.GAU_0170 1.1e-122 402.0 COG0823@1|root,COG0823@2|Bacteria,1ZTFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 GZD1_k127_4681162_68 760142.Hipma_0930 4.926e-49 191.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2M69Y@213113|Desulfurellales 28221|Deltaproteobacteria U Signal peptidase, peptidase S26 lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 GZD1_k127_4681162_23 861299.J421_4260 5.177e-112 388.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_4681162_103 357808.RoseRS_1163 6.993e-29 118.0 COG0361@1|root,COG0361@2|Bacteria,2G70W@200795|Chloroflexi,375UY@32061|Chloroflexia 32061|Chloroflexia J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a GZD1_k127_4681162_63 1089550.ATTH01000001_gene1532 2.453e-51 199.0 COG1462@1|root,COG1462@2|Bacteria 2|Bacteria M curli production assembly transport component CsgG - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - CsgG,FlgT_C GZD1_k127_4681162_128 1379270.AUXF01000007_gene1072 1.947e-14 85.0 2AETK@1|root,314QP@2|Bacteria,1ZU8P@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_136 604331.AUHY01000033_gene2397 2.612e-07 66.0 COG1520@1|root,COG5492@1|root,COG1520@2|Bacteria,COG5492@2|Bacteria,1WKKN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus N Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - Big_2,SBBP GZD1_k127_4681162_144 861299.J421_6329 5.227e-05 57.0 COG1470@1|root,COG5184@1|root,COG1470@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - F5_F8_type_C,Flg_new,RCC1,RCC1_2 GZD1_k127_4681162_57 379066.GAU_0502 4.926e-56 217.0 COG0840@1|root,COG0840@2|Bacteria,1ZSWC@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal GZD1_k127_4681162_73 1379270.AUXF01000002_gene1824 1.19e-44 184.0 COG0683@1|root,COG0683@2|Bacteria,1ZSQF@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 GZD1_k127_4681162_105 1297742.A176_04855 2.086e-28 115.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WQ3M@28221|Deltaproteobacteria,2Z1Q1@29|Myxococcales 28221|Deltaproteobacteria K Cold-shock protein cspD - - ko:K03704 - - - - ko00000,ko03000 - - - CSD GZD1_k127_4681162_41 290397.Adeh_2418 9.48e-79 277.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,42PT6@68525|delta/epsilon subdivisions,2WK6I@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.345 ko:K08256 - - R11702 - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 GZD1_k127_4681162_81 290397.Adeh_2417 8.737e-40 156.0 COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,42W09@68525|delta/epsilon subdivisions,2WRB8@28221|Deltaproteobacteria,2YVVC@29|Myxococcales 28221|Deltaproteobacteria G Polysaccharide deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Polysacc_deac_1 GZD1_k127_4681162_130 596152.DesU5LDRAFT_0960 1.058e-12 79.0 COG0392@1|root,COG0392@2|Bacteria,1N7DR@1224|Proteobacteria,42N4R@68525|delta/epsilon subdivisions,2X6K8@28221|Deltaproteobacteria,2MACN@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Lysylphosphatidylglycerol synthetase - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GZD1_k127_4681162_55 889204.HMPREF9423_0503 7.584e-57 212.0 COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,4HB11@91061|Bacilli,43FUT@68892|Streptococcus infantis 91061|Bacilli O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 GZD1_k127_4681162_58 794903.OPIT5_11905 1.616e-54 197.0 COG1704@1|root,COG1704@2|Bacteria,46V9M@74201|Verrucomicrobia,3K7DK@414999|Opitutae 414999|Opitutae S PFAM LemA family protein - - - ko:K03744 - - - - ko00000 - - - LemA GZD1_k127_4681162_82 861299.J421_0458 2.219e-39 156.0 COG0789@1|root,COG0789@2|Bacteria,1ZTHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 GZD1_k127_4681162_129 913865.DOT_2468 8.224e-14 77.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,2646G@186807|Peptococcaceae 186801|Clostridia T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat GZD1_k127_4681162_134 379066.GAU_0668 2.398e-10 70.0 COG2207@1|root,COG2207@2|Bacteria,1ZV67@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 GZD1_k127_4681162_138 379066.GAU_2769 8.513e-07 59.0 COG4970@1|root,COG4970@2|Bacteria,1ZU5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Tfp pilus assembly protein FimT - - - - - - - - - - - - - GZD1_k127_4681162_27 1379270.AUXF01000002_gene1474 1.413e-106 357.0 COG3437@1|root,COG3437@2|Bacteria,1ZTD3@142182|Gemmatimonadetes 142182|Gemmatimonadetes T HD domain - - - - - - - - - - - - HD,Response_reg GZD1_k127_4681162_28 861299.J421_0447 1.583e-103 346.0 COG2107@1|root,COG2107@2|Bacteria,1ZTVU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth GZD1_k127_4681162_109 861299.J421_0446 1.069e-26 118.0 2F3M0@1|root,33WE8@2|Bacteria,1ZTTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_8 525904.Tter_1390 1.106e-226 713.0 COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria 2|Bacteria E glutamine synthetase glnA GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N GZD1_k127_4681162_10 861299.J421_0444 1.224e-192 610.0 COG0174@1|root,COG0174@2|Bacteria,1ZSYQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glutamine synthetase, beta-Grasp domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N GZD1_k127_4681162_137 502025.Hoch_5171 3.754e-07 63.0 COG4775@1|root,COG4775@2|Bacteria,1Q2CZ@1224|Proteobacteria,437ZA@68525|delta/epsilon subdivisions,2X399@28221|Deltaproteobacteria,2YUX9@29|Myxococcales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - Bac_surface_Ag GZD1_k127_4681162_83 1122915.AUGY01000084_gene6195 8.43e-39 152.0 COG0346@1|root,COG0346@2|Bacteria,1VCGT@1239|Firmicutes,4HKDV@91061|Bacilli,26ZEW@186822|Paenibacillaceae 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase GZD1_k127_4681162_116 1094980.Mpsy_1851 1.623e-21 102.0 COG1309@1|root,arCOG02643@2157|Archaea 2157|Archaea K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N GZD1_k127_4681162_119 316067.Geob_0948 1.722e-19 104.0 COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran,OEP GZD1_k127_4681162_76 290397.Adeh_0225 5.742e-43 171.0 COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,42RBE@68525|delta/epsilon subdivisions,2WN7J@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 GZD1_k127_4681162_3 379066.GAU_2872 3.061e-311 985.0 COG0841@1|root,COG0841@2|Bacteria,1ZUFU@142182|Gemmatimonadetes 142182|Gemmatimonadetes V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran GZD1_k127_4681162_97 195250.CM001776_gene1399 1.433e-30 138.0 COG5305@1|root,COG5305@2|Bacteria,1G2NQ@1117|Cyanobacteria 1117|Cyanobacteria S Membrane - - - - - - - - - - - - PMT_2 GZD1_k127_4681162_118 195250.CM001776_gene2052 1.49e-19 103.0 COG5305@1|root,COG5305@2|Bacteria,1G2NQ@1117|Cyanobacteria 1117|Cyanobacteria S Membrane - - - - - - - - - - - - PMT_2 GZD1_k127_4681162_121 1123508.JH636449_gene7431 3.005e-18 99.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - ko:K14340 - - - - ko00000,ko01000,ko01003 - - - PMT_2 GZD1_k127_4681162_36 1120950.KB892747_gene3681 1.229e-87 303.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4DS0X@85009|Propionibacteriales 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short GZD1_k127_4681162_139 1379270.AUXF01000003_gene3671 2.001e-06 56.0 28W2Y@1|root,2ZI3W@2|Bacteria,1ZV8C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_126 1379270.AUXF01000003_gene3669 1.48e-14 86.0 2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_106 861299.J421_6360 3.394e-27 124.0 2F0M3@1|root,33TPR@2|Bacteria,1ZUAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4681162_143 1347086.CCBA010000012_gene2030 4.487e-05 45.0 2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - GZD1_k127_4681162_92 670307.HYPDE_33248 3.337e-35 141.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein nbaC GO:0000334,GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0044237,GO:0044248,GO:0051213,GO:0055114 1.13.11.6 ko:K00452 ko00380,ko01100,map00380,map01100 M00038 R02665 RC00387 ko00000,ko00001,ko00002,ko01000 - - - 3-HAO,Cupin_2 GZD1_k127_4681162_108 546414.Deide_17390 5.047e-27 118.0 COG1846@1|root,COG1846@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity slyA - - - - - - - - - - - HTH_27,MarR,MarR_2 GZD1_k127_4681162_132 298654.FraEuI1c_2647 9.776e-12 71.0 COG3794@1|root,COG3794@2|Bacteria,2HPHA@201174|Actinobacteria,4EWSY@85013|Frankiales 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - - GZD1_k127_4681162_107 1089550.ATTH01000001_gene468 4.375e-27 121.0 COG2345@1|root,COG2345@2|Bacteria,4PB2G@976|Bacteroidetes,1FJF8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_20 GZD1_k127_4681162_131 404589.Anae109_0243 2.195e-12 73.0 COG2010@1|root,COG2010@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c pcmF - - - - - - - - - - - Cytochrom_C GZD1_k127_4681162_6 452637.Oter_1803 3.814e-273 854.0 COG4263@1|root,COG4263@2|Bacteria,46YT5@74201|Verrucomicrobia,3K7SZ@414999|Opitutae 414999|Opitutae C Cupredoxin-like domain - - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - Cupredoxin_1 GZD1_k127_4681162_59 404589.Anae109_0245 2.147e-54 198.0 COG4314@1|root,COG4314@2|Bacteria,1R8N3@1224|Proteobacteria,42M7R@68525|delta/epsilon subdivisions,2WXID@28221|Deltaproteobacteria 28221|Deltaproteobacteria C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - - GZD1_k127_4681162_60 452637.Oter_1805 1.051e-53 206.0 COG3420@1|root,COG3420@2|Bacteria,46VQ1@74201|Verrucomicrobia,3K7SA@414999|Opitutae 414999|Opitutae P Domain present in carbohydrate binding proteins and sugar hydrolses - - - ko:K07218 - - - - ko00000 - - - NosD GZD1_k127_4681162_95 1476583.DEIPH_ctg050orf0017 6.552e-32 139.0 COG1131@1|root,COG1131@2|Bacteria,1WM0G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_4681162_114 404589.Anae109_0249 4.62e-23 109.0 COG1277@1|root,COG1277@2|Bacteria,1PK2D@1224|Proteobacteria,437V7@68525|delta/epsilon subdivisions,2WWIN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S ABC-2 family transporter protein - - - ko:K19341 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC2_membrane_2 GZD1_k127_4681162_44 83406.HDN1F_11850 5.972e-73 258.0 COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1R8PP@1224|Proteobacteria,1RZ8B@1236|Gammaproteobacteria,1JBBJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C,Cytochrome_CBB3,F5_F8_type_C GZD1_k127_4681162_85 926550.CLDAP_07260 6.25e-38 149.0 2E3MN@1|root,32YJW@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_4681162_112 926550.CLDAP_07270 5.258e-25 109.0 2DT85@1|root,33J4K@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_4681162_0 1382359.JIAL01000001_gene1490 0.0 1305.0 COG1048@1|root,COG1048@2|Bacteria,3Y34Q@57723|Acidobacteria,2JHMV@204432|Acidobacteriia 204432|Acidobacteriia C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C GZD1_k127_4681162_74 316067.Geob_3543 3.724e-43 160.0 2DM6D@1|root,31WQ8@2|Bacteria,1MZ7P@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - GZD1_k127_4681162_70 861299.J421_4431 1.627e-45 171.0 COG0454@1|root,COG0456@2|Bacteria,1ZU7K@142182|Gemmatimonadetes 142182|Gemmatimonadetes K acetyltransferase - - - - - - - - - - - - - GZD1_k127_4681162_78 391625.PPSIR1_38861 2.257e-42 177.0 COG3899@1|root,COG4191@1|root,COG3899@2|Bacteria,COG4191@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria 28221|Deltaproteobacteria T COG0515 Serine threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase GZD1_k127_4681162_61 880073.Calab_0511 2.939e-52 192.0 COG4221@1|root,COG4221@2|Bacteria,2NPJV@2323|unclassified Bacteria 2|Bacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short GZD1_k127_4681162_16 204669.Acid345_2868 1.677e-137 457.0 COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria,2JI17@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 GZD1_k127_4681162_18 379066.GAU_0454 8.938e-126 421.0 COG5267@1|root,COG5267@2|Bacteria,1ZSPP@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 GZD1_k127_4681162_93 1198452.Jab_2c21500 1.053e-34 143.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N GZD1_k127_4681162_50 1198452.Jab_2c21510 4.529e-61 229.0 COG2271@1|root,COG2271@2|Bacteria 2|Bacteria G transmembrane transporter activity - - - ko:K08225 - - - - ko00000,ko02000 2.A.1.38 - - MFS_1,MFS_3 GZD1_k127_4681162_17 861299.J421_2025 1.324e-128 422.0 COG2021@1|root,COG2021@2|Bacteria,1ZT4X@142182|Gemmatimonadetes 142182|Gemmatimonadetes E alpha/beta hydrolase fold - - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 GZD1_k127_4681162_77 861299.J421_4476 1.962e-42 164.0 COG2318@1|root,COG2318@2|Bacteria,1ZU06@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF664) - - - - - - - - - - - - DinB_2 GZD1_k127_4681162_32 215803.DB30_5985 8.185e-99 340.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria,2YZ88@29|Myxococcales 28221|Deltaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase GZD1_k127_4681162_90 861299.J421_1222 1.355e-35 153.0 COG1393@1|root,COG1393@2|Bacteria,1ZTUV@142182|Gemmatimonadetes 142182|Gemmatimonadetes P ArsC family - - - - - - - - - - - - ArsC GZD1_k127_4681162_51 1267535.KB906767_gene1290 9.845e-61 228.0 COG0697@1|root,COG0697@2|Bacteria,3Y570@57723|Acidobacteria 57723|Acidobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA GZD1_k127_4681162_7 1379270.AUXF01000002_gene1793 4.038e-271 850.0 COG0480@1|root,COG0480@2|Bacteria,1ZTFA@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU GZD1_k127_4681162_45 926556.Echvi_2920 3.718e-69 248.0 COG0644@1|root,COG0644@2|Bacteria,4NKR8@976|Bacteroidetes,47SE4@768503|Cytophagia 976|Bacteroidetes C TIGRFAM geranylgeranyl reductase family - - 1.3.99.38 ko:K21401 - - - - ko00000,ko01000 - - - FAD_binding_3,Trp_halogenase GZD1_k127_4681162_15 945713.IALB_3087 3.771e-140 453.0 COG1509@1|root,COG1509@2|Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_14,LAM_C,Radical_SAM GZD1_k127_4681162_99 530564.Psta_3376 3.196e-30 127.0 COG0454@1|root,COG1181@1|root,COG0456@2|Bacteria,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes 203682|Planctomycetes F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C GZD1_k127_4681162_62 1254432.SCE1572_16985 7.126e-52 196.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2Z0D8@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C GZD1_k127_4681162_40 1232410.KI421421_gene3684 3.989e-79 271.0 COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,43UHD@69541|Desulfuromonadales 28221|Deltaproteobacteria M ATP-grasp domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C GZD1_k127_4715657_0 861299.J421_1297 9.675e-187 590.0 COG0821@1|root,COG0821@2|Bacteria,1ZST3@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE GZD1_k127_4715657_2 1121373.KB903621_gene1916 1.495e-33 136.0 2CH1A@1|root,348NH@2|Bacteria 2|Bacteria S RDD family - - - - - - - - - - - - RDD GZD1_k127_4715657_1 313624.NSP_51600 2.646e-36 154.0 COG0073@1|root,COG0073@2|Bacteria,1G78D@1117|Cyanobacteria,1HNY1@1161|Nostocales 1117|Cyanobacteria J Export-related chaperone CsaA - - - ko:K06878 - - - - ko00000 - - - tRNA_bind GZD1_k127_4715657_4 861299.J421_3991 5.973e-16 91.0 29F5I@1|root,30238@2|Bacteria,1ZU4C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_4715657_3 861299.J421_6210 7.632e-28 116.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_6210|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_480396_0 861299.J421_6271 1.503e-270 843.0 COG0591@1|root,COG0591@2|Bacteria,1ZU9T@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF GZD1_k127_480396_8 861299.J421_6270 8.01e-07 62.0 2DJDE@1|root,305RC@2|Bacteria,1ZV7X@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_480396_2 861299.J421_1620 3.91e-169 545.0 COG3669@1|root,COG3669@2|Bacteria,1ZURK@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos GZD1_k127_480396_6 861299.J421_2204 1.558e-59 223.0 COG1209@1|root,COG1209@2|Bacteria 2|Bacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis GalU - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase GZD1_k127_480396_3 861299.J421_2203 1.476e-93 334.0 COG2334@1|root,COG2334@2|Bacteria 2|Bacteria S homoserine kinase activity mdsC - 2.7.1.162,2.7.1.39 ko:K02204,ko:K13059 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771,R08962 RC00002,RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APH GZD1_k127_480396_7 1382306.JNIM01000001_gene758 6.861e-36 157.0 COG0697@1|root,COG0697@2|Bacteria,2G8R9@200795|Chloroflexi 200795|Chloroflexi EG EamA-like transporter family - - - - - - - - - - - - EamA GZD1_k127_480396_1 861299.J421_2201 1.099e-238 751.0 COG0591@1|root,COG0591@2|Bacteria,1ZT5V@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Sodium:solute symporter family - - - - - - - - - - - - SSF GZD1_k127_480396_5 279714.FuraDRAFT_1014 3.614e-61 217.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2VR6F@28216|Betaproteobacteria,2KU3R@206351|Neisseriales 206351|Neisseriales O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR GZD1_k127_480396_4 292.DM42_7352 4.097e-69 239.0 COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2VKZ6@28216|Betaproteobacteria,1K04D@119060|Burkholderiaceae 28216|Betaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA2 - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR GZD1_k127_4809917_4 379066.GAU_1333 1.136e-06 55.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase GZD1_k127_4809917_6 1150469.RSPPHO_02781 0.0001803 47.0 COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales 204441|Rhodospirillales NU general secretion pathway protein - - - - - - - - - - - - - GZD1_k127_4809917_5 518766.Rmar_0885 4.7e-05 50.0 COG1561@1|root,COG1561@2|Bacteria,4NXM3@976|Bacteroidetes 2|Bacteria S YicC-like family, N-terminal region - - - - - - - - - - - - DUF1640,DUF1732,YicC_N GZD1_k127_4809917_0 861299.J421_0464 1.493e-133 443.0 COG0793@1|root,COG0793@2|Bacteria,1ZT92@142182|Gemmatimonadetes 142182|Gemmatimonadetes M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 GZD1_k127_4809917_2 1379698.RBG1_1C00001G0290 1.721e-90 326.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 GZD1_k127_4809917_1 1210884.HG799463_gene9923 8.82e-91 304.0 COG1878@1|root,COG1878@2|Bacteria,2J1IQ@203682|Planctomycetes 203682|Planctomycetes S Putative cyclase - - 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase GZD1_k127_4809917_3 861299.J421_1312 5.049e-49 183.0 COG2318@1|root,COG2318@2|Bacteria,1ZV4R@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DinB superfamily - - - - - - - - - - - - DinB_2 GZD1_k127_4822860_32 861299.J421_1666 5.62e-47 178.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4822860_25 330214.NIDE3611 1.439e-88 306.0 COG1723@1|root,COG1723@2|Bacteria 2|Bacteria S PFAM Uncharacterised ACR, YagE family COG1723 yagE - - - - - - - - - - - DUF155 GZD1_k127_4822860_14 204669.Acid345_0995 1.047e-141 459.0 COG3191@1|root,COG3191@2|Bacteria,3Y699@57723|Acidobacteria 57723|Acidobacteria M Peptidase family S58 - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 GZD1_k127_4822860_7 861299.J421_2042 2.754e-224 713.0 COG0308@1|root,COG0308@2|Bacteria,1ZU50@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 GZD1_k127_4822860_44 316273.XCV4456 4.715e-07 59.0 2EKP5@1|root,33ECX@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 GZD1_k127_4822860_30 215803.DB30_3707 2.193e-66 241.0 COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria,438Z7@68525|delta/epsilon subdivisions,2X8PT@28221|Deltaproteobacteria,2YY8K@29|Myxococcales 28221|Deltaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos GZD1_k127_4822860_40 215803.DB30_1146 6.845e-25 117.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1Q3GC@1224|Proteobacteria,4340P@68525|delta/epsilon subdivisions,2X4G1@28221|Deltaproteobacteria,2YYY6@29|Myxococcales 28221|Deltaproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 GZD1_k127_4822860_31 439235.Dalk_2462 2.451e-54 211.0 COG2208@1|root,COG3850@1|root,COG2208@2|Bacteria,COG3850@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2MIMK@213118|Desulfobacterales 28221|Deltaproteobacteria T Stage II sporulation protein E (SpoIIE) - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HAMP,SpoIIE GZD1_k127_4822860_37 1123267.JONN01000001_gene1239 1.996e-32 140.0 2C1YS@1|root,2ZD2Y@2|Bacteria 2|Bacteria S Protease prsW family - - - - - - - - - - - - PrsW-protease GZD1_k127_4822860_6 1123267.JONN01000001_gene1238 4.59e-225 732.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP GZD1_k127_4822860_38 383372.Rcas_2068 7.73e-28 119.0 COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi,375JF@32061|Chloroflexia 32061|Chloroflexia K PFAM sigma-70 region 2 domain protein - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_4822860_39 1121875.KB907547_gene2908 1.483e-26 116.0 COG0834@1|root,COG2172@1|root,COG2208@1|root,COG3829@1|root,COG0834@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,4PPGD@976|Bacteroidetes 976|Bacteroidetes T PAS domain - - - - - - - - - - - - - GZD1_k127_4822860_41 439235.Dalk_1049 1.861e-16 84.0 COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,42V1I@68525|delta/epsilon subdivisions,2WRH0@28221|Deltaproteobacteria,2MKP1@213118|Desulfobacterales 28221|Deltaproteobacteria T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS GZD1_k127_4822860_23 926554.KI912670_gene2029 1.368e-107 353.0 COG1402@1|root,COG1402@2|Bacteria,1WKXJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Creatinine amidohydrolase - - - - - - - - - - - - Creatininase GZD1_k127_4822860_18 1380394.JADL01000001_gene2987 1.389e-115 383.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JVH6@204441|Rhodospirillales 204441|Rhodospirillales H Ketopantoate reductase PanE/ApbA C terminal - - - - - - - - - - - - ApbA,ApbA_C GZD1_k127_4822860_24 1380391.JIAS01000004_gene2951 1.968e-107 362.0 COG1028@1|root,COG1028@2|Bacteria,1R6S5@1224|Proteobacteria,2U353@28211|Alphaproteobacteria,2JRX4@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 GZD1_k127_4822860_12 1121377.KB906402_gene3276 1.717e-187 597.0 COG0624@1|root,COG0624@2|Bacteria,1WMF4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 GZD1_k127_4822860_15 861299.J421_1133 1.772e-140 462.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid gadC GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039 - ko:K20265 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.3.7.1,2.A.3.7.3 - iEC042_1314.EC042_1624 AA_permease_2 GZD1_k127_4822860_21 997346.HMPREF9374_2257 2.316e-113 392.0 COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HC37@91061|Bacilli,27BPV@186824|Thermoactinomycetaceae 91061|Bacilli S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 GZD1_k127_4822860_34 234267.Acid_4874 1.331e-44 165.0 2ED19@1|root,336Y7@2|Bacteria,3Y95N@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - GZD1_k127_4822860_45 323848.Nmul_A2120 4.839e-06 50.0 COG3659@1|root,COG3659@2|Bacteria,1Q8C7@1224|Proteobacteria,2VJFC@28216|Betaproteobacteria,371UJ@32003|Nitrosomonadales 28216|Betaproteobacteria M Carbohydrate-selective porin, OprB family oprB - - - - - - - - - - - OprB GZD1_k127_4822860_2 1340493.JNIF01000004_gene135 0.0 1065.0 COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria 57723|Acidobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.2,3.6.3.6 ko:K01531,ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3,3.A.3.4 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase GZD1_k127_4822860_36 861299.J421_6201 2.422e-39 152.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_6201|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_4822860_35 861299.J421_0735 3.915e-44 171.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0735|- S peptidyl-tyrosine sulfation - - - ko:K13992 - - - - ko00000,ko00194 - - - - GZD1_k127_4822860_9 497964.CfE428DRAFT_6537 4.018e-221 707.0 COG1505@1|root,COG1505@2|Bacteria,46SRT@74201|Verrucomicrobia 74201|Verrucomicrobia E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N GZD1_k127_4822860_16 861299.J421_0888 1.031e-129 419.0 COG3622@1|root,COG3622@2|Bacteria,1ZT2P@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Xylose isomerase-like TIM barrel - - 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - - AP_endonuc_2 GZD1_k127_4822860_19 869210.Marky_0500 2.772e-115 389.0 COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM Glucose Sorbosone dehydrogenase - - - - - - - - - - - - GSDH GZD1_k127_4822860_3 1120965.AUBV01000001_gene3486 0.0 1032.0 COG2866@1|root,COG2866@2|Bacteria,4NGIE@976|Bacteroidetes,47N2M@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 GZD1_k127_4822860_8 1267534.KB906755_gene4821 2.126e-222 715.0 COG3345@1|root,COG3345@2|Bacteria,3Y44J@57723|Acidobacteria,2JIVW@204432|Acidobacteriia 204432|Acidobacteriia G alpha-galactosidase - - - - - - - - - - - - - GZD1_k127_4822860_4 861299.J421_1135 3.286e-275 861.0 COG2303@1|root,COG2303@2|Bacteria,1ZTG8@142182|Gemmatimonadetes 142182|Gemmatimonadetes E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N GZD1_k127_4822860_33 518766.Rmar_2789 4.882e-46 186.0 2CISN@1|root,2Z7MB@2|Bacteria,4NFJX@976|Bacteroidetes,1FJQ0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 GZD1_k127_4822860_11 861299.J421_1132 2.52e-193 610.0 COG0673@1|root,COG0673@2|Bacteria,1ZSVT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA GZD1_k127_4822860_27 518766.Rmar_1623 6.787e-84 287.0 COG3291@1|root,COG3291@2|Bacteria,4PMYH@976|Bacteroidetes 976|Bacteroidetes S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 GZD1_k127_4822860_26 1382359.JIAL01000001_gene2282 4.195e-87 304.0 COG0492@1|root,COG0492@2|Bacteria,3Y2NX@57723|Acidobacteria,2JI8S@204432|Acidobacteriia 204432|Acidobacteriia O L-lysine 6-monooxygenase (NADPH-requiring) - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_3 GZD1_k127_4822860_29 861299.J421_0787 7.871e-72 255.0 COG0631@1|root,COG0631@2|Bacteria,1ZSPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 GZD1_k127_4822860_20 204669.Acid345_0985 1.463e-113 398.0 COG0266@1|root,COG0266@2|Bacteria,3Y71J@57723|Acidobacteria,2JKGK@204432|Acidobacteriia 204432|Acidobacteriia L Formamidopyrimidine-DNA glycosylase H2TH domain - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS GZD1_k127_4822860_10 861299.J421_4263 2.587e-194 625.0 COG2234@1|root,COG2234@2|Bacteria,1ZT06@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 GZD1_k127_4822860_22 72228.T5AMZ4 6.491e-112 371.0 COG2421@1|root,2S3KN@2759|Eukaryota,39BWM@33154|Opisthokonta,3NYNE@4751|Fungi,3QJKM@4890|Ascomycota,217W5@147550|Sordariomycetes,3TIQD@5125|Hypocreales 4751|Fungi C Acetamidase/Formamidase family - - - - - - - - - - - - FmdA_AmdA GZD1_k127_4822860_0 861299.J421_3669 0.0 1321.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 GZD1_k127_4822860_5 1340493.JNIF01000003_gene4527 1.468e-243 776.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria 57723|Acidobacteria EU Dienelactone hydrolase family - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9 GZD1_k127_4822860_1 861299.J421_6091 0.0 1288.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ GZD1_k127_4822860_28 309807.SRU_0883 1.042e-77 280.0 COG0457@1|root,COG0457@2|Bacteria,4NFMI@976|Bacteroidetes,1FK5M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 GZD1_k127_4822860_13 1379270.AUXF01000002_gene1585 6.066e-166 554.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase GZD1_k127_4822860_17 1379270.AUXF01000007_gene968 7.474e-124 429.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000007_gene968|- KLT protein kinase activity - - - - - - - - - - - - - GZD1_k127_4822860_43 1249997.JHZW01000003_gene3688 3.141e-10 66.0 2CEJ5@1|root,2Z7RK@2|Bacteria,4NGWQ@976|Bacteroidetes,1I0KC@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - Phenol_MetA_deg GZD1_k127_4830386_15 861299.J421_3986 1.566e-10 66.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE - - ko:K02456,ko:K02650,ko:K02655 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - ComP_DUS,N_methyl GZD1_k127_4830386_11 861299.J421_3986 5.928e-23 105.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE - - ko:K02456,ko:K02650,ko:K02655 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - ComP_DUS,N_methyl GZD1_k127_4830386_2 1336243.JAEA01000012_gene2921 1.992e-134 436.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TVFX@28211|Alphaproteobacteria,1JZ5D@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP GZD1_k127_4830386_7 861299.J421_0733 1.591e-52 192.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity - - 3.1.3.23 ko:K19270 - - - - ko00000,ko01000 - - - HAD_2 GZD1_k127_4830386_6 402881.Plav_0006 5.646e-65 243.0 COG0740@1|root,COG0740@2|Bacteria,1RBNX@1224|Proteobacteria,2U5ZH@28211|Alphaproteobacteria,1JNRR@119043|Rhodobiaceae 28211|Alphaproteobacteria OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP3 - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease GZD1_k127_4830386_0 861299.J421_3951 7.288e-136 440.0 COG0714@1|root,COG0714@2|Bacteria,1ZT5U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 GZD1_k127_4830386_5 1191523.MROS_0276 2.578e-67 244.0 COG0356@1|root,COG0356@2|Bacteria 2|Bacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A GZD1_k127_4830386_12 1121930.AQXG01000002_gene1905 4.045e-17 84.0 COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C GZD1_k127_4830386_14 1122993.KB898328_gene610 8.467e-11 70.0 COG0711@1|root,COG0711@2|Bacteria,4NQKA@976|Bacteroidetes,2FQWH@200643|Bacteroidia 976|Bacteroidetes C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B GZD1_k127_4830386_9 861299.J421_3944 4.726e-37 147.0 COG0712@1|root,COG0712@2|Bacteria,1ZTP8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP GZD1_k127_4830386_4 861299.J421_2267 5.013e-86 297.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4830386_1 1379270.AUXF01000003_gene3431 3.396e-135 466.0 COG0308@1|root,COG0308@2|Bacteria,1ZUT0@142182|Gemmatimonadetes 2|Bacteria E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 GZD1_k127_4830386_10 292459.STH516 6.357e-31 130.0 COG1149@1|root,COG1149@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding napF - - ko:K02572,ko:K02573 - - - - ko00000 - - - Fer4,Fer4_4,Fer4_6,Fer4_7,Fer4_9 GZD1_k127_4830386_8 404589.Anae109_2286 3.854e-43 162.0 COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria 1224|Proteobacteria G Mannose-6-phosphate isomerase - - - - - - - - - - - - Cupin_2,MannoseP_isomer GZD1_k127_4830386_3 861299.J421_3942 4.126e-122 402.0 COG1208@1|root,COG1208@2|Bacteria,1ZSYR@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase GZD1_k127_4830386_13 1121413.JMKT01000009_gene1954 1.948e-14 77.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg GZD1_k127_4883092_15 887062.HGR_13939 1.088e-23 104.0 COG3216@1|root,COG3216@2|Bacteria,1N1Q6@1224|Proteobacteria 1224|Proteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - - - - - - - - - - DUF2062 GZD1_k127_4883092_14 1121930.AQXG01000015_gene1844 1.781e-25 123.0 COG2982@1|root,COG2982@2|Bacteria 2|Bacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - TamB GZD1_k127_4883092_7 1121918.ARWE01000001_gene3039 1.353e-96 325.0 COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria,42M4K@68525|delta/epsilon subdivisions,2WWCN@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel GZD1_k127_4883092_4 1144275.COCOR_03147 6.32e-163 541.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,4360M@68525|delta/epsilon subdivisions,2X2HZ@28221|Deltaproteobacteria,2Z0WC@29|Myxococcales 28221|Deltaproteobacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 GZD1_k127_4883092_13 468059.AUHA01000002_gene760 1.208e-39 160.0 COG0628@1|root,COG0628@2|Bacteria,4NIB3@976|Bacteroidetes,1INZE@117747|Sphingobacteriia 976|Bacteroidetes S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport GZD1_k127_4883092_10 861299.J421_1020 1.486e-72 280.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C GZD1_k127_4883092_6 639030.JHVA01000001_gene3758 5.213e-118 390.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 GZD1_k127_4883092_11 1288494.EBAPG3_13880 1.618e-71 262.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2WGWX@28216|Betaproteobacteria,37279@32003|Nitrosomonadales 28216|Betaproteobacteria T Cache domain - - - - - - - - - - - - GGDEF,HAMP,dCache_1 GZD1_k127_4883092_16 1121405.dsmv_2333 0.0002365 52.0 COG3807@1|root,COG3807@2|Bacteria,1RIYJ@1224|Proteobacteria,42SNK@68525|delta/epsilon subdivisions,2WPNS@28221|Deltaproteobacteria,2MK8E@213118|Desulfobacterales 28221|Deltaproteobacteria S SH3 domain - - - - - - - - - - - - SH3_4 GZD1_k127_4883092_8 1144275.COCOR_03639 4.134e-77 268.0 COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,42Q5T@68525|delta/epsilon subdivisions 1224|Proteobacteria S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 GZD1_k127_4883092_5 1128421.JAGA01000002_gene1750 1.222e-150 482.0 COG0667@1|root,COG0667@2|Bacteria,2NP23@2323|unclassified Bacteria 2|Bacteria C Aldo/keto reductase family yghZ - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red GZD1_k127_4883092_9 1192034.CAP_6021 6.184e-74 272.0 COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42QTM@68525|delta/epsilon subdivisions,2WN5R@28221|Deltaproteobacteria,2YZM4@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulatory protein, C terminal kdpE - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C GZD1_k127_4883092_0 671143.DAMO_0414 7.986e-305 958.0 COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria 2|Bacteria T Osmosensitive K+ channel His kinase sensor domain - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,KdpD,Usp GZD1_k127_4883092_3 1267533.KB906736_gene1230 3.186e-187 612.0 2CB8G@1|root,2Z88H@2|Bacteria,3Y6TH@57723|Acidobacteria,2JMKE@204432|Acidobacteriia 204432|Acidobacteriia S Putative beta-barrel porin-2, OmpL-like. bbp2 - - - - - - - - - - - - BBP2 GZD1_k127_4883092_12 1121033.AUCF01000004_gene4789 6.621e-59 209.0 COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2TSQ7@28211|Alphaproteobacteria,2JSFW@204441|Rhodospirillales 204441|Rhodospirillales P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex kdpC - 3.6.3.12 ko:K01548 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpC GZD1_k127_4883092_1 204669.Acid345_0511 2.229e-287 897.0 COG2216@1|root,COG2216@2|Bacteria,3Y302@57723|Acidobacteria,2JHQI@204432|Acidobacteriia 204432|Acidobacteriia P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system kdpB - 3.6.3.12 ko:K01547 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - E1-E2_ATPase,Hydrolase GZD1_k127_4883092_2 485913.Krac_1219 8.921e-210 665.0 COG2060@1|root,COG2060@2|Bacteria,2G5KK@200795|Chloroflexi 200795|Chloroflexi P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane - - 3.6.3.12 ko:K01546 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpA GZD1_k127_4973224_12 1379270.AUXF01000005_gene793 7.634e-45 174.0 COG3121@1|root,COG3121@2|Bacteria 2|Bacteria NU pilus organization - - - ko:K07346 - - - - ko00000,ko02035,ko02044,ko03110 - - - PapD_N GZD1_k127_4973224_13 1267535.KB906767_gene2509 2.988e-16 91.0 COG1988@1|root,COG1988@2|Bacteria,3Y305@57723|Acidobacteria,2JHQ5@204432|Acidobacteriia 204432|Acidobacteriia S LexA-binding, inner membrane-associated putative hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM GZD1_k127_4973224_10 1379270.AUXF01000005_gene462 4.465e-81 292.0 COG0515@1|root,COG0515@2|Bacteria,1ZTB4@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_4973224_7 1254432.SCE1572_13235 2.12e-97 330.0 COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2YU3D@29|Myxococcales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 GZD1_k127_4973224_6 1123508.JH636441_gene3666 4.667e-107 357.0 COG1131@1|root,COG1131@2|Bacteria,2IY2I@203682|Planctomycetes 203682|Planctomycetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_4973224_8 861299.J421_3562 1.322e-89 310.0 COG0477@1|root,COG2814@2|Bacteria,1ZT84@142182|Gemmatimonadetes 2|Bacteria EGP Sugar (and other) transporter - - - ko:K08153 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8 - - MFS_1,Sugar_tr GZD1_k127_4973224_5 997346.HMPREF9374_2151 5.422e-115 392.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,27CKY@186824|Thermoactinomycetaceae 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 GZD1_k127_4973224_11 42256.RradSPS_1163 1.304e-77 272.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria 201174|Actinobacteria E Belongs to the ABC transporter superfamily fbpC - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 GZD1_k127_4973224_9 517418.Ctha_1134 5.326e-89 306.0 COG1840@1|root,COG1840@2|Bacteria 2|Bacteria P iron ion homeostasis - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 GZD1_k127_4973224_3 861299.J421_0065 1.912e-161 537.0 COG2120@1|root,COG2120@2|Bacteria,1ZT6U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L GZD1_k127_4973224_0 404589.Anae109_2419 2.175e-221 703.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2X5G7@28221|Deltaproteobacteria,2Z35F@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GZD1_k127_4973224_14 1489678.RDMS_11110 4.312e-10 69.0 COG1926@1|root,COG1926@2|Bacteria,1WKAM@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - Pribosyltran GZD1_k127_4973224_1 710111.FraQA3DRAFT_4770 6.358e-210 659.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales 201174|Actinobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt GZD1_k127_4973224_4 667632.KB890217_gene4870 1.069e-128 422.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C GZD1_k127_4973224_2 861299.J421_5946 1.651e-209 665.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUMT@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 GZD1_k127_4981005_4 234267.Acid_4989 2.248e-93 314.0 COG3620@1|root,COG3620@2|Bacteria,3Y6X6@57723|Acidobacteria 57723|Acidobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 GZD1_k127_4981005_10 1267534.KB906760_gene1554 1.254e-32 129.0 2DD3Z@1|root,2ZGDH@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_4981005_7 861299.J421_2198 3.838e-48 174.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR GZD1_k127_4981005_3 1267535.KB906767_gene4612 1.417e-149 509.0 COG0577@1|root,COG0577@2|Bacteria 1267535.KB906767_gene4612|- V efflux transmembrane transporter activity - - - - - - - - - - - - - GZD1_k127_4981005_11 204669.Acid345_2646 6.002e-08 63.0 298RU@1|root,2ZVW4@2|Bacteria,3Y4I6@57723|Acidobacteria,2JMQI@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - GZD1_k127_4981005_1 204669.Acid345_3459 1.906e-217 701.0 COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria,2JK7N@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_4981005_5 1123073.KB899242_gene1301 1.05e-53 197.0 298RU@1|root,3059D@2|Bacteria,1QRA7@1224|Proteobacteria,1TDHB@1236|Gammaproteobacteria,1XAQM@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - GZD1_k127_4981005_9 861299.J421_0639 3.861e-33 132.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR GZD1_k127_4981005_0 861299.J421_0704 9.569e-291 924.0 COG0577@1|root,COG0577@2|Bacteria,1ZUI2@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_4981005_2 682795.AciX8_0140 1.361e-194 621.0 COG4941@1|root,COG4941@2|Bacteria,3Y38B@57723|Acidobacteria,2JP46@204432|Acidobacteriia 204432|Acidobacteriia K Sigma-70 region 2 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_4981005_8 204669.Acid345_3072 1.148e-40 154.0 COG3795@1|root,COG3795@2|Bacteria,3Y89G@57723|Acidobacteria,2JNCT@204432|Acidobacteriia 204432|Acidobacteriia S YCII-related domain - - - - - - - - - - - - YCII GZD1_k127_4981005_6 861299.J421_5892 1.107e-50 182.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR GZD1_k127_4981005_12 298655.KI912266_gene6305 8.193e-05 51.0 COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria,4ERJR@85013|Frankiales 201174|Actinobacteria H PFAM bifunctional deaminase-reductase domain protein - - - - - - - - - - - - RibD_C GZD1_k127_5039675_4 1121481.AUAS01000039_gene5321 7.037e-12 74.0 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,47MMF@768503|Cytophagia 976|Bacteroidetes Q Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD GZD1_k127_5039675_0 861299.J421_0180 4.635e-200 647.0 COG3590@1|root,COG3590@2|Bacteria 2|Bacteria O peptidase - - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N GZD1_k127_5039675_1 861299.J421_4331 2.458e-112 371.0 COG1234@1|root,COG1234@2|Bacteria,1ZTG7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 GZD1_k127_5039675_2 234267.Acid_1095 6.424e-44 168.0 COG5662@1|root,COG5662@2|Bacteria,3Y511@57723|Acidobacteria 57723|Acidobacteria K AntiSigma factor - - - - - - - - - - - - zf-HC2 GZD1_k127_5039675_3 485913.Krac_10224 1.928e-41 157.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_5111927_3 861299.J421_0180 5.821e-137 447.0 COG3590@1|root,COG3590@2|Bacteria 2|Bacteria O peptidase - - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N GZD1_k127_5111927_25 1121481.AUAS01000039_gene5321 9.162e-17 92.0 COG1463@1|root,COG1463@2|Bacteria,4NHT9@976|Bacteroidetes,47MMF@768503|Cytophagia 976|Bacteroidetes Q Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD GZD1_k127_5111927_10 1379270.AUXF01000004_gene3177 2.11e-66 250.0 COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran GZD1_k127_5111927_12 379066.GAU_2574 6.397e-54 201.0 COG0767@1|root,COG0767@2|Bacteria,1ZSUC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE GZD1_k127_5111927_9 379066.GAU_0824 1.33e-67 243.0 COG1194@1|root,COG1194@2|Bacteria,1ZTNM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L FES - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD GZD1_k127_5111927_20 861299.J421_4333 1.555e-27 116.0 COG4911@1|root,COG4911@2|Bacteria 2|Bacteria S Uncharacterized conserved protein (DUF2203) - - - - - - - - - - - - DUF2203 GZD1_k127_5111927_28 570268.ANBB01000025_gene5672 1.817e-06 60.0 COG0517@1|root,COG0517@2|Bacteria,2IM3K@201174|Actinobacteria,4EJIF@85012|Streptosporangiales 201174|Actinobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS GZD1_k127_5111927_23 742767.HMPREF9456_02934 2.124e-20 102.0 COG1752@1|root,COG1752@2|Bacteria,4NERH@976|Bacteroidetes,2FNX7@200643|Bacteroidia,22XKQ@171551|Porphyromonadaceae 976|Bacteroidetes S Phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin GZD1_k127_5111927_13 861299.J421_4334 2.337e-51 189.0 COG1607@1|root,COG1607@2|Bacteria,1ZTQ1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thioesterase superfamily - - - - - - - - - - - - 4HBT GZD1_k127_5111927_0 861299.J421_4453 3.28e-213 682.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1ZTC2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H NAD synthase - - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase GZD1_k127_5111927_22 269799.Gmet_3016 9.504e-23 108.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,43V8X@69541|Desulfuromonadales 28221|Deltaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB GZD1_k127_5111927_19 269799.Gmet_3017 9.111e-35 143.0 COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,42TZK@68525|delta/epsilon subdivisions,2WQ2E@28221|Deltaproteobacteria,43SQ1@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - CBS,DUF190 GZD1_k127_5111927_29 1499967.BAYZ01000073_gene2017 1.584e-05 57.0 COG1470@1|root,COG2885@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,2NPWP@2323|unclassified Bacteria 2|Bacteria M OmpA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - DUF4384,DUF4625,OmpA,PEGA GZD1_k127_5111927_27 1487953.JMKF01000095_gene5206 3.51e-08 61.0 COG3453@1|root,COG3453@2|Bacteria,1G5H7@1117|Cyanobacteria 1117|Cyanobacteria O TIGRFAM TIGR01244 family protein - - - - - - - - - - - - DUF442 GZD1_k127_5111927_30 1206726.BAFV01000020_gene1342 0.0004327 49.0 COG4319@1|root,COG4319@2|Bacteria,2I5M3@201174|Actinobacteria,4G9MJ@85025|Nocardiaceae 201174|Actinobacteria S Nuclear transport factor 2 (NTF2) domain ksdI - 5.3.3.1 ko:K01822 ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120 M00107,M00110 R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955 RC00146,RC00762 ko00000,ko00001,ko00002,ko01000 - - - SnoaL_2 GZD1_k127_5111927_24 661478.OP10G_4182 2.464e-19 101.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - - - - - - - - - - AhpC-TSA GZD1_k127_5111927_14 1128421.JAGA01000001_gene2151 1.733e-49 188.0 COG1957@1|root,COG1957@2|Bacteria,2NPG1@2323|unclassified Bacteria 2|Bacteria F Inosine-uridine preferring nucleoside hydrolase iunH - 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro GZD1_k127_5111927_11 257310.BB3383 8.897e-55 204.0 COG1250@1|root,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2VJ64@28216|Betaproteobacteria,3T24A@506|Alcaligenaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase - - - - - - - - - - - - 3HCDH,3HCDH_N GZD1_k127_5111927_16 861299.J421_4362 9.2e-44 180.0 COG0589@1|root,COG0589@2|Bacteria,1ZTUZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Universal stress protein family - - - - - - - - - - - - Usp GZD1_k127_5111927_1 861299.J421_4364 2.718e-208 656.0 COG1914@1|root,COG1914@2|Bacteria,1ZT3I@142182|Gemmatimonadetes 142182|Gemmatimonadetes U H( )-stimulated, divalent metal cation uptake system mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp GZD1_k127_5111927_8 1379270.AUXF01000001_gene2649 3.947e-70 245.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1ZTHJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress,FeoA GZD1_k127_5111927_18 379066.GAU_2716 3.706e-35 142.0 COG1051@1|root,COG1051@2|Bacteria,1ZU0E@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX GZD1_k127_5111927_6 861299.J421_4371 4.511e-78 275.0 COG1215@1|root,COG1215@2|Bacteria,1ZU0V@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 21 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 GZD1_k127_5111927_2 1120954.ATXE01000001_gene2372 6.525e-153 496.0 COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4DNVF@85009|Propionibacteriales 201174|Actinobacteria E O-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP GZD1_k127_5111927_5 1379270.AUXF01000003_gene3655 7.392e-83 298.0 COG0460@1|root,COG2021@1|root,COG0460@2|Bacteria,COG2021@2|Bacteria,1ZU32@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Homoserine_dh,NAD_binding_3 GZD1_k127_5111927_4 1382356.JQMP01000004_gene188 1.546e-115 388.0 COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,27YSW@189775|Thermomicrobia 189775|Thermomicrobia E Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 GZD1_k127_5111927_7 1121468.AUBR01000067_gene934 4.472e-75 276.0 COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,42FEE@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf GZD1_k127_5111927_15 1379270.AUXF01000001_gene2634 1.959e-48 180.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_5111927_26 861299.J421_4376 2.997e-14 81.0 2F756@1|root,33ZKP@2|Bacteria,1ZU38@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5111927_21 1123256.KB907944_gene423 6.309e-25 116.0 COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales 135614|Xanthomonadales S Putative adhesin - - - - - - - - - - - - DUF4097 GZD1_k127_5111927_17 1379270.AUXF01000001_gene2631 5.21e-41 162.0 COG3595@1|root,COG3595@2|Bacteria,1ZTQ0@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - DUF4097 GZD1_k127_5159791_2 1379270.AUXF01000006_gene26 4.327e-63 241.0 COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 GZD1_k127_5159791_0 379066.GAU_1932 6.314e-114 376.0 COG0142@1|root,COG0142@2|Bacteria,1ZT7D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt GZD1_k127_5159791_3 1379270.AUXF01000006_gene28 1.493e-25 108.0 2FH8C@1|root,3492Q@2|Bacteria,1ZTXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4321) - - - - - - - - - - - - DUF4321 GZD1_k127_5159791_6 706587.Desti_1723 9.758e-09 59.0 COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42V5P@68525|delta/epsilon subdivisions,2WRM0@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 GZD1_k127_5159791_5 1321781.HMPREF1985_01362 5.207e-10 62.0 COG1826@1|root,COG1826@2|Bacteria,1VFP2@1239|Firmicutes,4H5YN@909932|Negativicutes 909932|Negativicutes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system - - - - - - - - - - - - MttA_Hcf106 GZD1_k127_5159791_1 861299.J421_3538 8.516e-114 389.0 COG0760@1|root,COG0760@2|Bacteria,1ZTD1@142182|Gemmatimonadetes 142182|Gemmatimonadetes O SurA N-terminal domain - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_2 GZD1_k127_5159791_4 861299.J421_3537 6.01e-22 109.0 COG0457@1|root,COG0457@2|Bacteria,1ZTTU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 GZD1_k127_5182949_1 479434.Sthe_0227 0.0 1186.0 COG0587@1|root,COG0587@2|Bacteria,2G811@200795|Chloroflexi,27Z3J@189775|Thermomicrobia 189775|Thermomicrobia L Belongs to the DNA polymerase type-C family. DnaE2 subfamily - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP GZD1_k127_5182949_5 479434.Sthe_2045 3.09e-52 201.0 COG0389@1|root,COG0389@2|Bacteria 2|Bacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII imuB - 2.7.7.7 ko:K02346,ko:K14161 - - - - ko00000,ko01000,ko03400 - - - IMS GZD1_k127_5182949_3 379066.GAU_0477 1.006e-78 273.0 COG1801@1|root,COG1801@2|Bacteria 2|Bacteria L Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 GZD1_k127_5182949_6 86416.Clopa_2728 4.534e-32 142.0 COG4331@1|root,COG4331@2|Bacteria,1VHU2@1239|Firmicutes,24JRU@186801|Clostridia,36Q8J@31979|Clostridiaceae 186801|Clostridia S membrane protein (DUF2127) - - - - - - - - - - - - DUF2127 GZD1_k127_5182949_0 379066.GAU_1314 0.0 1264.0 COG3696@1|root,COG3696@2|Bacteria,1ZUB0@142182|Gemmatimonadetes 2|Bacteria P AcrB/AcrD/AcrF family cusA - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran GZD1_k127_5182949_2 379066.GAU_1315 8.888e-83 289.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cebB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA GZD1_k127_5182949_4 379066.GAU_1316 1.091e-69 252.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity cebC - - - - - - - - - - - OEP GZD1_k127_5182949_7 697282.Mettu_3886 9.654e-07 59.0 COG1749@1|root,COG2319@1|root,COG2372@1|root,COG1749@2|Bacteria,COG2319@2|Bacteria,COG2372@2|Bacteria,1MWJA@1224|Proteobacteria,1S1AJ@1236|Gammaproteobacteria,1XF66@135618|Methylococcales 135618|Methylococcales N WD40 repeat, subgroup - - - - - - - - - - - - Big_5,DUF4082,WD40 GZD1_k127_528673_7 1547437.LL06_09535 4.933e-111 367.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2TUF8@28211|Alphaproteobacteria,43IA0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I fatty acid desaturase des - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase GZD1_k127_528673_21 861299.J421_4422 1.264e-14 86.0 2C9AW@1|root,2ZVNX@2|Bacteria,1ZUAK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_528673_18 861299.J421_4539 1.296e-27 119.0 28YSJ@1|root,2ZKJZ@2|Bacteria,1ZU1U@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_528673_20 861299.J421_4540 3.858e-21 98.0 COG0296@1|root,COG0296@2|Bacteria 2|Bacteria G 1,4-alpha-glucan branching enzyme activity - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - AMPK1_CBM,Alpha-amylase,Alpha-amylase_C,CBM_48 GZD1_k127_528673_12 861299.J421_4541 2.56e-47 193.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigX - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 GZD1_k127_528673_22 616991.JPOO01000003_gene640 5.657e-10 72.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia,23HX8@178469|Arenibacter 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 GZD1_k127_528673_23 1379270.AUXF01000004_gene3307 1.902e-06 60.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CARDB,Peptidase_M30 GZD1_k127_528673_10 375286.mma_2596 2.438e-70 249.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VUIT@28216|Betaproteobacteria,476WJ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA GZD1_k127_528673_0 379066.GAU_1366 3.928e-279 876.0 COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase GZD1_k127_528673_4 379066.GAU_1365 1.129e-151 494.0 COG0297@1|root,COG0297@2|Bacteria,1ZUKP@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Synthesizes alpha-1,4-glucan chains using ADP-glucose - - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 GZD1_k127_528673_6 1303518.CCALI_02107 3.249e-121 427.0 COG1543@1|root,COG1543@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 57 family - GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K03406,ko:K16149 ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko02035 - GH57 - DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1 GZD1_k127_528673_5 861299.J421_0427 1.092e-137 474.0 COG1449@1|root,COG1449@2|Bacteria,1ZTEQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Domain of unknown function (DUF3536) - - - - - - - - - - - - DUF3536,Glyco_hydro_57 GZD1_k127_528673_8 1205680.CAKO01000007_gene4238 2.539e-109 383.0 COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg GZD1_k127_528673_16 1379270.AUXF01000002_gene1247 2.642e-35 141.0 COG4636@1|root,COG4636@2|Bacteria,1ZVA4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 GZD1_k127_528673_19 926569.ANT_07960 1.171e-25 119.0 2DN0I@1|root,32UR2@2|Bacteria,2G8Y2@200795|Chloroflexi 200795|Chloroflexi S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 GZD1_k127_528673_1 401053.AciPR4_3833 5.155e-233 740.0 COG1501@1|root,COG1501@2|Bacteria,3Y4PF@57723|Acidobacteria,2JJDQ@204432|Acidobacteriia 204432|Acidobacteriia G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - Gal_mutarotas_2,Glyco_hydro_31 GZD1_k127_528673_15 861299.J421_2082 2.257e-35 141.0 COG4636@1|root,COG4636@2|Bacteria,1ZVA4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative restriction endonuclease - - - - - - - - - - - - Uma2 GZD1_k127_528673_13 861299.J421_1967 2.849e-45 180.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - - GZD1_k127_528673_9 861299.J421_1934 9.562e-99 334.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - - GZD1_k127_528673_2 861299.J421_5759 8.637e-165 544.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_528673_3 861299.J421_0279 3.242e-152 513.0 COG0577@1|root,COG0577@2|Bacteria 861299.J421_0279|- V efflux transmembrane transporter activity - - - - - - - - - - - - - GZD1_k127_528673_14 1267533.KB906733_gene3356 2.943e-38 145.0 COG1695@1|root,COG1695@2|Bacteria,3Y8BI@57723|Acidobacteria 57723|Acidobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR GZD1_k127_528673_24 1150469.RSPPHO_02781 2.438e-06 49.0 COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales 204441|Rhodospirillales NU general secretion pathway protein - - - - - - - - - - - - - GZD1_k127_528673_17 517418.Ctha_1616 6.372e-34 134.0 COG1858@1|root,COG1858@2|Bacteria,1FDVA@1090|Chlorobi 1090|Chlorobi C PFAM Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C GZD1_k127_5303743_15 945713.IALB_0512 1.033e-103 345.0 COG1814@1|root,COG1814@2|Bacteria 2|Bacteria S cellular manganese ion homeostasis - - - - - - - - - - - - Rubrerythrin,VIT1 GZD1_k127_5303743_1 861299.J421_2423 0.0 1058.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 GZD1_k127_5303743_38 484770.UFO1_3056 2.465e-32 145.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H2VB@909932|Negativicutes 909932|Negativicutes NT SMART chemotaxis sensory transducer, histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 GZD1_k127_5303743_25 1496688.ER33_02515 9.632e-86 309.0 COG0111@1|root,COG0111@2|Bacteria,1FZZU@1117|Cyanobacteria,22S1G@167375|Cyanobium 1117|Cyanobacteria E D-isomer specific 2-hydroxyacid dehydrogenase serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT GZD1_k127_5303743_22 379066.GAU_0192 7.142e-96 327.0 COG0075@1|root,COG0075@2|Bacteria,1ZTF3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 GZD1_k127_5303743_41 1408473.JHXO01000005_gene1511 6.772e-31 130.0 COG1335@1|root,COG1335@2|Bacteria 2|Bacteria Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase,MerR_1 GZD1_k127_5303743_43 1128421.JAGA01000003_gene3445 5.564e-30 128.0 COG1246@1|root,COG1246@2|Bacteria,2NRHE@2323|unclassified Bacteria 2|Bacteria E Acetyltransferase (GNAT) domain argH GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K00619,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000 - - - ASL_C2,Acetyltransf_1,Lyase_1 GZD1_k127_5303743_17 3075.A0A087SPX6 2.797e-103 351.0 COG4992@1|root,KOG1401@2759|Eukaryota,37JRF@33090|Viridiplantae 33090|Viridiplantae E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.11 ko:K00818 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02283 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 GZD1_k127_5303743_37 926550.CLDAP_16920 2.024e-34 144.0 COG0548@1|root,COG0548@2|Bacteria,2G6ZG@200795|Chloroflexi 200795|Chloroflexi F Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase GZD1_k127_5303743_24 861299.J421_1328 1.927e-87 299.0 COG0002@1|root,COG0002@2|Bacteria,1ZSV7@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC GZD1_k127_5303743_9 379066.GAU_3591 6.506e-124 422.0 COG0623@1|root,COG0623@2|Bacteria,1ZTGW@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Enoyl-(Acyl carrier protein) reductase - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GZD1_k127_5303743_5 469383.Cwoe_5866 3.65e-144 464.0 COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4CQTG@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - Isochorismatase,QRPTase_C,QRPTase_N GZD1_k127_5303743_26 1121441.AUCX01000034_gene1581 9.815e-75 259.0 COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,43BKJ@68525|delta/epsilon subdivisions,2WIZJ@28221|Deltaproteobacteria,2M9AT@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_5303743_14 1379270.AUXF01000002_gene1837 3.379e-107 358.0 COG1446@1|root,COG1446@2|Bacteria,1ZTAQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Asparaginase - - 3.5.1.26 ko:K01444 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Asparaginase_2 GZD1_k127_5303743_50 378806.STAUR_2958 3.95e-14 85.0 COG4775@1|root,COG4775@2|Bacteria,1RDM0@1224|Proteobacteria,42S2Q@68525|delta/epsilon subdivisions,2WNSG@28221|Deltaproteobacteria,2YX6N@29|Myxococcales 28221|Deltaproteobacteria M Surface antigen - - - - - - - - - - - - Bac_surface_Ag GZD1_k127_5303743_8 861299.J421_2400 3.451e-135 441.0 COG1748@1|root,COG1748@2|Bacteria,1ZSMC@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Saccharopine dehydrogenase C-terminal domain - - 1.4.1.18 ko:K19064 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R00446,R02317 RC00062,RC00694 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP GZD1_k127_5303743_49 1235279.C772_00906 7.115e-15 82.0 COG1309@1|root,COG1309@2|Bacteria,1V95E@1239|Firmicutes,4HJIZ@91061|Bacilli 91061|Bacilli K Transcriptional regulator - - - ko:K22106 - - - - ko00000,ko03000 - - - TetR_C_10,TetR_N GZD1_k127_5303743_34 903818.KI912268_gene2396 1.012e-46 184.0 COG1408@1|root,COG1408@2|Bacteria,3Y4DF@57723|Acidobacteria 57723|Acidobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos GZD1_k127_5303743_32 1502852.FG94_03088 1.354e-49 193.0 COG0793@1|root,COG0793@2|Bacteria,1Q13M@1224|Proteobacteria,2W62A@28216|Betaproteobacteria 28216|Betaproteobacteria M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 GZD1_k127_5303743_33 661478.OP10G_2718 2.898e-48 182.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - AXE1,DLH GZD1_k127_5303743_20 1183438.GKIL_3325 6.597e-97 334.0 COG2133@1|root,COG2133@2|Bacteria,1G5E2@1117|Cyanobacteria 1117|Cyanobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH GZD1_k127_5303743_21 1123277.KB893243_gene340 3.982e-96 341.0 COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes,47NMM@768503|Cytophagia 976|Bacteroidetes E Peptidase family M1 domain - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,Peptidase_M1 GZD1_k127_5303743_29 861299.J421_3598 2.009e-56 213.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 2|Bacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C GZD1_k127_5303743_28 1379270.AUXF01000007_gene1075 8.372e-65 241.0 COG0515@1|root,COG3170@1|root,COG0515@2|Bacteria,COG3170@2|Bacteria,1ZTGA@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_5303743_4 379066.GAU_0485 5.51e-157 509.0 COG0745@1|root,COG2199@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1ZT7F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg GZD1_k127_5303743_27 861299.J421_2397 2.159e-68 244.0 COG1171@1|root,COG1171@2|Bacteria,1ZTBP@142182|Gemmatimonadetes 2|Bacteria E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP GZD1_k127_5303743_0 861299.J421_2396 0.0 1141.0 COG0188@1|root,COG0188@2|Bacteria,1ZTFF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV GZD1_k127_5303743_10 861299.J421_2390 1.889e-121 401.0 COG0604@1|root,COG0604@2|Bacteria,1ZT6R@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N GZD1_k127_5303743_46 1499967.BAYZ01000090_gene4945 7.244e-22 112.0 COG0823@1|root,COG1807@1|root,COG0823@2|Bacteria,COG1807@2|Bacteria,2NPHZ@2323|unclassified Bacteria 2|Bacteria U WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K08676 - - - - ko00000,ko01000,ko01002,ko02000 2.C.1.2 - - PD40,PMT_2,Peptidase_S41,Tricorn_C1 GZD1_k127_5303743_47 1210884.HG799464_gene10849 5.371e-18 95.0 COG4319@1|root,COG4319@2|Bacteria,2J3B0@203682|Planctomycetes 203682|Planctomycetes S Calcium/calmodulin dependent protein kinase II association domain - - - - - - - - - - - - SnoaL_3 GZD1_k127_5303743_42 1500890.JQNL01000001_gene3631 1.113e-30 139.0 COG1228@1|root,COG1228@2|Bacteria,1RCA0@1224|Proteobacteria,1S08B@1236|Gammaproteobacteria,1X5NR@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 GZD1_k127_5303743_3 666685.R2APBS1_3302 2.73e-163 546.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1X5RA@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 GZD1_k127_5303743_16 768710.DesyoDRAFT_4626 1.269e-103 354.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,260DU@186807|Peptococcaceae 186801|Clostridia F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C GZD1_k127_5303743_52 1293048.CBMB010000007_gene3089 2.146e-05 55.0 COG0589@1|root,arCOG00449@2157|Archaea,2XU1E@28890|Euryarchaeota,23TYX@183963|Halobacteria 183963|Halobacteria T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp GZD1_k127_5303743_30 379066.GAU_0468 1.487e-55 211.0 COG0328@1|root,COG0328@2|Bacteria,1ZTI8@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H GZD1_k127_5303743_45 1288484.APCS01000044_gene48 2.992e-22 106.0 COG2131@1|root,COG2131@2|Bacteria 2|Bacteria F dCMP deaminase activity comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 GZD1_k127_5303743_35 861299.J421_1819 5.563e-42 170.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - 1.7.2.1 ko:K00368,ko:K02638 ko00195,ko00910,ko01120,map00195,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko00194,ko01000 - - - Copper-bind,Cupredoxin_1 GZD1_k127_5303743_44 861299.J421_2370 7.978e-30 127.0 2F95J@1|root,341H1@2|Bacteria,1ZTZZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5303743_19 378806.STAUR_4874 9.453e-99 340.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales 28221|Deltaproteobacteria C Dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh GZD1_k127_5303743_2 1267533.KB906734_gene4176 1.749e-211 663.0 COG4447@1|root,COG4447@2|Bacteria,3Y3TM@57723|Acidobacteria,2JHSZ@204432|Acidobacteriia 204432|Acidobacteriia S cellulose binding - - - - - - - - - - - - BNR GZD1_k127_5303743_36 234267.Acid_5295 1.337e-34 137.0 COG1977@1|root,COG1977@2|Bacteria,3Y5J3@57723|Acidobacteria 57723|Acidobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - - - - - - - - - - - GZD1_k127_5303743_7 290397.Adeh_0062 9.829e-136 443.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2Z30V@29|Myxococcales 28221|Deltaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K07508 ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00085,M00087,M00088,M00095,M00373,M00374,M00375 R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747 RC00004,RC00326,RC00405,RC01702 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N GZD1_k127_5303743_23 644282.Deba_1222 1.084e-93 321.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 GZD1_k127_5303743_48 1379270.AUXF01000002_gene1802 1.521e-16 91.0 2FK9E@1|root,34BX2@2|Bacteria,1ZTYM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5303743_11 671143.DAMO_2551 9.725e-114 375.0 COG1250@1|root,COG1250@2|Bacteria,2NP11@2323|unclassified Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N GZD1_k127_5303743_51 243233.MCA1825 1.169e-12 78.0 COG4244@1|root,COG4244@2|Bacteria,1NB74@1224|Proteobacteria,1SI9C@1236|Gammaproteobacteria,1XF4F@135618|Methylococcales 135618|Methylococcales S Predicted membrane protein (DUF2231) - - - - - - - - - - - - DUF2231 GZD1_k127_5303743_40 1157490.EL26_01200 2.157e-31 143.0 COG1852@1|root,COG1852@2|Bacteria,1V1B5@1239|Firmicutes,4HUDI@91061|Bacilli,279H3@186823|Alicyclobacillaceae 91061|Bacilli S Protein of unknown function DUF116 - - - - - - - - - - - - DUF116 GZD1_k127_5303743_13 861299.J421_2362 3.281e-111 377.0 COG0277@1|root,COG0277@2|Bacteria,1ZTB7@142182|Gemmatimonadetes 142182|Gemmatimonadetes C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 GZD1_k127_5303743_12 1379270.AUXF01000002_gene1798 3.491e-112 366.0 COG1351@1|root,COG1351@2|Bacteria,1ZTEP@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 GZD1_k127_5303743_18 1191523.MROS_1829 2.001e-101 341.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlA - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C GZD1_k127_5303743_31 886293.Sinac_6202 2.825e-51 197.0 COG1181@1|root,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes 203682|Planctomycetes F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C GZD1_k127_5303743_39 207559.Dde_3044 1.91e-31 130.0 COG0454@1|root,COG0456@2|Bacteria,1MYK6@1224|Proteobacteria,42TT3@68525|delta/epsilon subdivisions,2WQGD@28221|Deltaproteobacteria,2MCMQ@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 GZD1_k127_5303743_6 945713.IALB_3087 3.224e-139 451.0 COG1509@1|root,COG1509@2|Bacteria 2|Bacteria E lysine 2,3-aminomutase activity kamA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_14,LAM_C,Radical_SAM GZD1_k127_5324592_22 1121406.JAEX01000025_gene2536 2.727e-42 171.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2M9YK@213115|Desulfovibrionales 28221|Deltaproteobacteria O XdhC and CoxI family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3,XdhC_C,XdhC_CoxI GZD1_k127_5324592_21 861299.J421_2342 2.592e-43 160.0 COG0599@1|root,COG0599@2|Bacteria,1ZTRJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD GZD1_k127_5324592_17 861299.J421_3626 1.84e-59 227.0 COG5557@1|root,COG5557@2|Bacteria,1ZTCE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pfam Polysulphide reductase, NrfD - - - - - - - - - - - - - GZD1_k127_5324592_26 379066.GAU_2033 1.095e-19 96.0 COG2010@1|root,COG2010@2|Bacteria,1ZTPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 GZD1_k127_5324592_23 1379270.AUXF01000003_gene3824 3.817e-40 157.0 COG2010@1|root,COG2010@2|Bacteria,1ZTMS@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF3341) - - - - - - - - - - - - DUF3341 GZD1_k127_5324592_3 861299.J421_3629 1.976e-161 521.0 COG5557@1|root,COG5557@2|Bacteria,1ZSN2@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD GZD1_k127_5324592_1 861299.J421_3630 3.992e-222 722.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal GZD1_k127_5324592_24 269799.Gmet_1809 8.664e-37 145.0 COG3474@1|root,COG3474@2|Bacteria,1QUNA@1224|Proteobacteria,42PVG@68525|delta/epsilon subdivisions,2X7M4@28221|Deltaproteobacteria,43VY9@69541|Desulfuromonadales 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - - GZD1_k127_5324592_0 760192.Halhy_5402 0.0 1206.0 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria,4NK01@976|Bacteroidetes,1IWVG@117747|Sphingobacteriia 976|Bacteroidetes T Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 GZD1_k127_5324592_14 521045.Kole_0682 1.45e-69 251.0 COG4948@1|root,COG4948@2|Bacteria 2|Bacteria M carboxylic acid catabolic process menC GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C,MR_MLE_C,MR_MLE_N GZD1_k127_5324592_8 935845.JADQ01000007_gene1677 4.363e-95 327.0 COG0167@1|root,COG0167@2|Bacteria,1U0E8@1239|Firmicutes,4I9RR@91061|Bacilli,271WX@186822|Paenibacillaceae 91061|Bacilli F dihydroorotate dehydrogenase activity - - - - - - - - - - - - - GZD1_k127_5324592_16 935845.JADQ01000007_gene1676 1.31e-60 228.0 COG0329@1|root,COG0329@2|Bacteria,1U034@1239|Firmicutes,4I9D8@91061|Bacilli,271D2@186822|Paenibacillaceae 91061|Bacilli EM Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS GZD1_k127_5324592_15 861299.J421_3632 1.066e-66 239.0 COG2159@1|root,COG2159@2|Bacteria,1ZTHS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S amidohydrolase - - - - - - - - - - - - - GZD1_k127_5324592_7 861299.J421_3633 5.516e-103 341.0 COG2159@1|root,COG2159@2|Bacteria,1ZSXA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 GZD1_k127_5324592_9 379066.GAU_2040 9.508e-85 294.0 COG0001@1|root,COG0001@2|Bacteria,1ZSWU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 GZD1_k127_5324592_19 861299.J421_3635 3.973e-57 214.0 COG0565@1|root,COG0565@2|Bacteria,1ZT19@142182|Gemmatimonadetes 142182|Gemmatimonadetes J SpoU rRNA Methylase family - - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase GZD1_k127_5324592_5 861299.J421_3636 2.076e-145 497.0 2AEF2@1|root,314A1@2|Bacteria,1ZSNZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Heparinase II/III-like protein - - - - - - - - - - - - Hepar_II_III GZD1_k127_5324592_18 1128421.JAGA01000002_gene806 6.184e-58 216.0 COG2605@1|root,COG2605@2|Bacteria 1128421.JAGA01000002_gene806|- G GHMP kinase - - - - - - - - - - - - - GZD1_k127_5324592_6 861299.J421_3637 1.266e-115 389.0 COG0747@1|root,COG0747@2|Bacteria,1ZTAS@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 GZD1_k127_5324592_12 194439.CT1631 1.65e-76 270.0 COG0601@1|root,COG0601@2|Bacteria,1FDDB@1090|Chlorobi 1090|Chlorobi P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 GZD1_k127_5324592_13 861299.J421_3639 3.256e-70 259.0 COG1173@1|root,COG1173@2|Bacteria,1ZTI1@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 GZD1_k127_5324592_20 518766.Rmar_2647 3.952e-49 182.0 COG0400@1|root,COG0400@2|Bacteria,4NHWT@976|Bacteroidetes,1FJF1@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Serine hydrolase (FSH1) - - - - - - - - - - - - Abhydrolase_2,FSH1 GZD1_k127_5324592_2 861299.J421_3641 7.428e-168 559.0 COG0383@1|root,COG0383@2|Bacteria,1ZT4Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38 GZD1_k127_5324592_4 575540.Isop_1098 1.608e-158 528.0 COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,2J2BS@203682|Planctomycetes 203682|Planctomycetes M Phosphoesterase family - - - - - - - - - - - - Lactonase,Phosphoesterase GZD1_k127_5324592_10 926569.ANT_18060 3.22e-84 295.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi 200795|Chloroflexi G Belongs to the GPI family pgi - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA GZD1_k127_5324592_11 316274.Haur_4259 9.621e-77 289.0 COG0745@1|root,COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,GAF_3,HATPase_c,HisKA,PAS_4,Response_reg GZD1_k127_5332708_5 204669.Acid345_2819 1.738e-10 67.0 COG2234@1|root,COG2234@2|Bacteria,3Y435@57723|Acidobacteria,2JKND@204432|Acidobacteriia 204432|Acidobacteriia S Transferrin receptor-like dimerisation domain - - 3.4.17.21 ko:K01301 - - - - ko00000,ko01000,ko01002 - - - PA,Peptidase_M28,TFR_dimer GZD1_k127_5332708_7 101510.RHA1_ro06178 7.811e-05 55.0 COG3794@1|root,COG3794@2|Bacteria,2GSBM@201174|Actinobacteria,4G2JT@85025|Nocardiaceae 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 GZD1_k127_5332708_1 1123508.JH636455_gene45 4.328e-98 339.0 COG2234@1|root,COG2234@2|Bacteria,2IZHS@203682|Planctomycetes 203682|Planctomycetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 GZD1_k127_5332708_2 266117.Rxyl_1327 1.929e-70 243.0 COG2514@1|root,COG2514@2|Bacteria,2HNS6@201174|Actinobacteria,4CPZV@84995|Rubrobacteria 84995|Rubrobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase GZD1_k127_5332708_0 404589.Anae109_0887 2.46e-223 704.0 COG1012@1|root,COG1012@2|Bacteria,1QWN5@1224|Proteobacteria,43BT3@68525|delta/epsilon subdivisions,2X73T@28221|Deltaproteobacteria,2YU0C@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the aldehyde dehydrogenase family pruA - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh GZD1_k127_5332708_6 243164.DET1448 2.485e-10 67.0 29WVC@1|root,30IH0@2|Bacteria,2G9KW@200795|Chloroflexi,34DPM@301297|Dehalococcoidia 301297|Dehalococcoidia - - - - - - - - - - - - - - - GZD1_k127_5332708_3 1267533.KB906737_gene1564 5.884e-49 195.0 COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia 204432|Acidobacteriia O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH GZD1_k127_5332708_4 861299.J421_4541 2.154e-24 119.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigX - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 GZD1_k127_5346850_79 378806.STAUR_8259 5.21e-13 79.0 COG3391@1|root,COG4412@1|root,COG3391@2|Bacteria,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CARDB,Peptidase_M30,VCBS GZD1_k127_5346850_65 383372.Rcas_0525 2.195e-32 143.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi,3757W@32061|Chloroflexia 32061|Chloroflexia KLT Serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8 GZD1_k127_5346850_80 861299.J421_3012 1.761e-11 68.0 COG2919@1|root,COG2919@2|Bacteria,1ZU6R@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Septum formation initiator - - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC GZD1_k127_5346850_7 861299.J421_3011 1.229e-191 607.0 COG0148@1|root,COG0148@2|Bacteria,1ZTAB@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N GZD1_k127_5346850_56 335543.Sfum_1596 3.357e-41 165.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2MRQY@213462|Syntrophobacterales 28221|Deltaproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase GZD1_k127_5346850_39 861299.J421_3009 8.437e-71 250.0 COG0611@1|root,COG0611@2|Bacteria,1ZTIU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C GZD1_k127_5346850_83 345073.VC395_1472 2.761e-06 60.0 COG2199@1|root,COG3292@1|root,COG3292@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RQCR@1236|Gammaproteobacteria,1XW8K@135623|Vibrionales 135623|Vibrionales T Y_Y_Y domain - - - - - - - - - - - - GGDEF,Reg_prop,Y_Y_Y GZD1_k127_5346850_37 861299.J421_3008 5.866e-75 273.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1ZTAT@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N GZD1_k127_5346850_41 1125863.JAFN01000001_gene341 1.276e-68 242.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo GZD1_k127_5346850_64 861299.J421_3006 1.788e-32 132.0 2E5IJ@1|root,3309Y@2|Bacteria,1ZTU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5346850_10 1267533.KB906740_gene374 8.554e-169 543.0 COG0112@1|root,COG0112@2|Bacteria,3Y2JB@57723|Acidobacteria,2JI87@204432|Acidobacteriia 204432|Acidobacteriia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT GZD1_k127_5346850_57 679199.HMPREF9332_01757 9.551e-41 154.0 COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,2FT1X@200643|Bacteroidia,1WDD6@1283313|Alloprevotella 976|Bacteroidetes G Ribose/Galactose Isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB GZD1_k127_5346850_15 861299.J421_3004 2.602e-149 483.0 COG0334@1|root,COG0334@2|Bacteria,1ZTBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N GZD1_k127_5346850_19 861299.J421_3003 1.386e-133 438.0 COG1960@1|root,COG1960@2|Bacteria,1ZSRC@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GZD1_k127_5346850_25 518766.Rmar_0752 3.015e-108 368.0 COG1250@1|root,COG1250@2|Bacteria,4NGU8@976|Bacteroidetes,1FJ15@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain hbd - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N GZD1_k127_5346850_73 1330700.JQNC01000003_gene750 5.661e-24 111.0 COG1268@1|root,COG1268@2|Bacteria,1WJ9M@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM BioY protein bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY GZD1_k127_5346850_13 379066.GAU_1289 6.538e-161 515.0 COG0183@1|root,COG0183@2|Bacteria,1ZTGX@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N GZD1_k127_5346850_6 479434.Sthe_0456 1.251e-205 658.0 COG0441@1|root,COG0441@2|Bacteria,2G5PZ@200795|Chloroflexi,27XPW@189775|Thermomicrobia 189775|Thermomicrobia J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD GZD1_k127_5346850_1 861299.J421_2994 0.0 1043.0 COG0525@1|root,COG0525@2|Bacteria,1ZSXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 GZD1_k127_5346850_50 861299.J421_2993 1.205e-44 181.0 COG4704@1|root,COG4704@2|Bacteria 2|Bacteria - - - - - ko:K07274 - - - - ko00000,ko02000 9.B.99.1 - - DUF2141,MipA GZD1_k127_5346850_22 1125863.JAFN01000001_gene282 2.809e-115 401.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA GZD1_k127_5346850_55 1123371.ATXH01000022_gene968 1.968e-41 158.0 COG0241@1|root,COG0241@2|Bacteria,2GHMG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Polynucleotide kinase 3 phosphatase - - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like GZD1_k127_5346850_81 1229172.JQFA01000002_gene3999 6.492e-10 69.0 COG0265@1|root,COG0265@2|Bacteria,1G0XN@1117|Cyanobacteria,1H8PC@1150|Oscillatoriales 1117|Cyanobacteria O COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PPC,Trypsin_2 GZD1_k127_5346850_45 861299.J421_2990 2.298e-53 196.0 COG0299@1|root,COG0299@2|Bacteria,1ZTKJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N GZD1_k127_5346850_72 1379270.AUXF01000001_gene2011 2.03e-24 116.0 COG1363@1|root,COG1363@2|Bacteria 2|Bacteria G aminopeptidase activity - - - - - - - - - - - - Peptidase_M28,Peptidase_M42 GZD1_k127_5346850_34 926566.Terro_1276 3.55e-78 281.0 COG1363@1|root,COG1363@2|Bacteria,3Y2Y3@57723|Acidobacteria,2JKCI@204432|Acidobacteriia 204432|Acidobacteriia G PFAM M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 GZD1_k127_5346850_8 1379270.AUXF01000005_gene585 3.054e-184 600.0 COG0138@1|root,COG0138@2|Bacteria,1ZT6N@142182|Gemmatimonadetes 142182|Gemmatimonadetes F AICARFT/IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS GZD1_k127_5346850_12 861299.J421_2988 5.428e-163 537.0 COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity - - - - - - - - - - - - - GZD1_k127_5346850_9 861299.J421_2988 6.56e-175 575.0 COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity - - - - - - - - - - - - - GZD1_k127_5346850_75 1218076.BAYB01000058_gene6234 2.224e-19 93.0 2EQUD@1|root,33IE5@2|Bacteria,1NBUY@1224|Proteobacteria,2VU7T@28216|Betaproteobacteria,1KG4F@119060|Burkholderiaceae 28216|Betaproteobacteria S YXWGXW repeat (2 copies) - - - - - - - - - - - - YXWGXW GZD1_k127_5346850_24 1089551.KE386572_gene4476 5.562e-109 367.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,4BPCX@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c GZD1_k127_5346850_84 861299.J421_2984 5.559e-05 54.0 2FFNT@1|root,347K5@2|Bacteria,1ZTY9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5346850_18 861299.J421_3701 1.275e-140 456.0 COG0436@1|root,COG0436@2|Bacteria,1ZTCU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 GZD1_k127_5346850_4 861299.J421_2981 5.038e-263 848.0 COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1ZT1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HELICc2 - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2,RadC GZD1_k127_5346850_11 379066.GAU_1255 1.196e-166 542.0 2CD20@1|root,2Z7SQ@2|Bacteria,1ZTFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5346850_47 861299.J421_2978 1.241e-49 198.0 COG1729@1|root,COG1729@2|Bacteria,1ZTBJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - - GZD1_k127_5346850_32 1379270.AUXF01000005_gene566 3.595e-84 316.0 COG1196@1|root,COG1196@2|Bacteria,1ZSU8@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - GZD1_k127_5346850_33 861299.J421_2976 2.777e-82 279.0 COG1657@1|root,COG1657@2|Bacteria,1ZSPV@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 GZD1_k127_5346850_40 861299.J421_2975 8.891e-70 245.0 COG0313@1|root,COG0313@2|Bacteria,1ZTK1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase GZD1_k127_5346850_54 861299.J421_2974 2.795e-42 157.0 COG3118@1|root,COG3118@2|Bacteria,1ZTS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Thioredoxin-like domain - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin GZD1_k127_5346850_53 861299.J421_2973 1.315e-42 160.0 COG0346@1|root,COG0346@2|Bacteria,1ZTMU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 GZD1_k127_5346850_35 1296990.H845_3079 2.713e-76 262.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2JPM4@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ GZD1_k127_5346850_77 861299.J421_2970 5.532e-16 92.0 2CB0K@1|root,343GC@2|Bacteria,1ZU4A@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - Hpt GZD1_k127_5346850_44 1379270.AUXF01000005_gene558 1.489e-58 219.0 COG0392@1|root,COG0392@2|Bacteria,1ZT5W@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GZD1_k127_5346850_51 861299.J421_2968 3.91e-44 177.0 COG1947@1|root,COG1947@2|Bacteria,1ZTM9@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N GZD1_k127_5346850_46 861299.J421_1249 6.514e-53 191.0 2AG3M@1|root,31687@2|Bacteria,1ZV0Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5346850_21 1463901.JOIY01000044_gene141 2.535e-115 386.0 COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - ko:K08166 - - - - ko00000,ko02000 2.A.1.3.10 - - MFS_1 GZD1_k127_5346850_68 1379270.AUXF01000005_gene669 3.953e-27 122.0 COG1776@1|root,COG1776@2|Bacteria,1ZTIW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT CheC-like family - - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC GZD1_k127_5346850_59 379066.GAU_1405 5.848e-39 148.0 COG2204@1|root,COG2204@2|Bacteria,1ZTMH@142182|Gemmatimonadetes 142182|Gemmatimonadetes T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg GZD1_k127_5346850_26 290397.Adeh_1383 7.532e-100 343.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2X5MZ@28221|Deltaproteobacteria,2Z36F@29|Myxococcales 28221|Deltaproteobacteria J catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg GZD1_k127_5346850_31 290397.Adeh_0601 1.711e-89 311.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2YX13@29|Myxococcales 28221|Deltaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR2 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N,Response_reg GZD1_k127_5346850_52 1242864.D187_000270 1.022e-42 161.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42TN2@68525|delta/epsilon subdivisions,2WR0G@28221|Deltaproteobacteria,2Z094@29|Myxococcales 28221|Deltaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW GZD1_k127_5346850_30 1134474.O59_002791 2.446e-90 321.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1FH61@10|Cellvibrio 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_4,sCache_2 GZD1_k127_5346850_20 404589.Anae109_0647 2.567e-128 436.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42Y7C@68525|delta/epsilon subdivisions,2WTJH@28221|Deltaproteobacteria,2YXEJ@29|Myxococcales 28221|Deltaproteobacteria NT Chemotaxis protein histidine kinase and related kinases cheA2 - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt GZD1_k127_5346850_71 385682.AFSL01000008_gene2579 1.813e-24 111.0 COG1871@1|root,COG1871@2|Bacteria,4NQUM@976|Bacteroidetes,2G1N1@200643|Bacteroidia,3XJZE@558415|Marinilabiliaceae 976|Bacteroidetes NT CheD chemotactic sensory transduction cheD - - - - - - - - - - - CheD GZD1_k127_5346850_66 404589.Anae109_0650 4.087e-32 131.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,4321Z@68525|delta/epsilon subdivisions,2WWZ3@28221|Deltaproteobacteria,2Z0DC@29|Myxococcales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - PilZ,Response_reg GZD1_k127_5346850_42 861299.J421_0411 4.863e-67 252.0 COG0583@1|root,COG0583@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - - - - - - - - - - HTH_1,LysR_substrate GZD1_k127_5346850_60 861299.J421_0554 2.538e-37 156.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0554|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_5346850_36 1297742.A176_06822 1.315e-75 267.0 COG3361@1|root,COG3361@2|Bacteria 2|Bacteria S conserved protein (COG2071) - - - ko:K09166 - - - - ko00000 - - - DUF2071 GZD1_k127_5346850_61 381666.H16_A3595 1.161e-36 144.0 2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria,1KDIQ@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 GZD1_k127_5346850_28 861299.J421_1374 1.265e-93 319.0 COG2423@1|root,COG2423@2|Bacteria 2|Bacteria E ornithine cyclodeaminase activity ocd2 - 1.4.1.1,1.5.1.25,4.3.1.12 ko:K01750,ko:K18258,ko:K19244 ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230 - R00396,R00671 RC00008,RC00354 ko00000,ko00001,ko01000,ko04147 - - - OCD_Mu_crystall GZD1_k127_5346850_38 706587.Desti_0194 8.129e-75 258.0 COG4275@1|root,COG4275@2|Bacteria,1PKNN@1224|Proteobacteria,42XSF@68525|delta/epsilon subdivisions,2WTCB@28221|Deltaproteobacteria,2MSBS@213462|Syntrophobacterales 28221|Deltaproteobacteria S Chromate resistance exported protein - - - - - - - - - - - - Chrome_Resist GZD1_k127_5346850_0 861299.J421_6304 0.0 1295.0 COG4447@1|root,COG4447@2|Bacteria,1ZUBH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 GZD1_k127_5346850_29 204669.Acid345_4600 7.568e-91 317.0 COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria,2JJG2@204432|Acidobacteriia 204432|Acidobacteriia E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 GZD1_k127_5346850_23 861299.J421_5753 2.901e-113 379.0 COG3867@1|root,COG3867@2|Bacteria 2|Bacteria G arabinogalactan endo-1,4-beta-galactosidase activity - - 3.2.1.23,3.2.1.89 ko:K01190,ko:K01224 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - CBM_6,Glyco_hydro_53 GZD1_k127_5346850_78 861299.J421_1356 1.023e-14 79.0 2A77G@1|root,30W3N@2|Bacteria,1ZV7D@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5346850_5 861299.J421_6111 1.048e-233 747.0 COG2091@1|root,COG2091@2|Bacteria,1ZUKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - GZD1_k127_5346850_16 861299.J421_2967 2.79e-147 472.0 COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N GZD1_k127_5346850_48 379066.GAU_1218 1.566e-48 182.0 COG1825@1|root,COG1825@2|Bacteria,1ZTHZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance - - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C GZD1_k127_5346850_49 1379270.AUXF01000005_gene524 1.996e-46 173.0 COG0193@1|root,COG0193@2|Bacteria,1ZTKT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro GZD1_k127_5346850_14 379066.GAU_1208 1.838e-153 492.0 COG0012@1|root,COG0012@2|Bacteria,1ZSPQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C GZD1_k127_5346850_70 1379270.AUXF01000005_gene514 8.546e-25 109.0 COG0360@1|root,COG0360@2|Bacteria,1ZTYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 GZD1_k127_5346850_69 379066.GAU_1205 2.146e-26 109.0 COG0238@1|root,COG0238@2|Bacteria,1ZU47@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 GZD1_k127_5346850_82 861299.J421_2951 2.007e-08 66.0 2F1RZ@1|root,33US3@2|Bacteria,1ZUSC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - DUF2232 GZD1_k127_5346850_62 1121451.DESAM_22224 3.274e-35 139.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2MAU8@213115|Desulfovibrionales 28221|Deltaproteobacteria J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N GZD1_k127_5346850_27 883.DvMF_0600 2.285e-96 338.0 COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,42U2G@68525|delta/epsilon subdivisions,2WQBG@28221|Deltaproteobacteria,2M8TG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Dihydroxyacetone kinase family - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV GZD1_k127_5346850_67 861299.J421_2949 7.187e-31 125.0 COG0799@1|root,COG0799@2|Bacteria,1ZU0S@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS GZD1_k127_5346850_2 861299.J421_2948 2.159e-294 937.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1ZSUS@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - Bac_surface_Ag,PD40 GZD1_k127_5346850_63 861299.J421_2947 1.233e-34 149.0 COG3087@1|root,COG3087@2|Bacteria,1ZSYS@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR GZD1_k127_5346850_74 861299.J421_2946 6.061e-24 117.0 COG3087@1|root,COG3087@2|Bacteria,1ZTII@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR GZD1_k127_5346850_3 861299.J421_2945 4.066e-280 900.0 COG1196@1|root,COG1196@2|Bacteria,1ZSY1@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge GZD1_k127_5346850_43 1379698.RBG1_1C00001G1263 5.382e-65 251.0 COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria 2|Bacteria O Subtilase family aprN - - - - - - - - - - - Peptidase_S8 GZD1_k127_5346850_17 861299.J421_2942 4.523e-143 461.0 COG2876@1|root,COG2876@2|Bacteria,1ZTB0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 GZD1_k127_5346850_76 861299.J421_2941 1.086e-17 97.0 COG2834@1|root,COG2834@2|Bacteria,1ZTXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Outer membrane lipoprotein carrier protein LolA - - - ko:K03634 - - - - ko00000 - - - LolA GZD1_k127_5346850_58 383372.Rcas_3715 2.019e-40 160.0 COG5495@1|root,COG5495@2|Bacteria,2G6F3@200795|Chloroflexi,377DR@32061|Chloroflexia 32061|Chloroflexia S PFAM NADP oxidoreductase coenzyme F420-dependent - - - - - - - - - - - - DUF2520,Rossmann-like GZD1_k127_5347702_5 395495.Lcho_2430 1.866e-06 52.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,1KJG8@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM GZD1_k127_5347702_1 314285.KT71_002883 9.29e-13 78.0 2EQR5@1|root,33IB0@2|Bacteria,1NNKG@1224|Proteobacteria,1SIH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_5347702_2 1122243.KB903808_gene2301 5.111e-09 62.0 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SF0T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 GZD1_k127_5347702_4 1266914.ATUK01000016_gene437 6.042e-08 63.0 COG0589@1|root,COG0589@2|Bacteria,1NGA1@1224|Proteobacteria,1SH57@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp GZD1_k127_5347702_0 671143.DAMO_3124 4.621e-61 226.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,SpoIIE,sCache_3_2 GZD1_k127_5347702_3 452637.Oter_1727 5.46e-08 55.0 COG0745@1|root,COG0745@2|Bacteria,46SHU@74201|Verrucomicrobia,3K8NC@414999|Opitutae 414999|Opitutae K Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C GZD1_k127_535565_14 1379270.AUXF01000004_gene2918 1.839e-56 202.0 COG1595@1|root,COG1595@2|Bacteria,1ZUWF@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF GZD1_k127_535565_5 1379270.AUXF01000004_gene2919 8.641e-149 504.0 COG0515@1|root,COG0515@2|Bacteria,1ZUF3@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_535565_7 1267533.KB906735_gene4667 1.738e-143 471.0 COG1858@1|root,COG1858@2|Bacteria 2|Bacteria C electron transfer activity - - - - - - - - - - - - CCP_MauG GZD1_k127_535565_6 379066.GAU_2766 5.801e-146 470.0 COG2132@1|root,COG2132@2|Bacteria,1ZUZP@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase_3 GZD1_k127_535565_11 926566.Terro_3219 2.613e-80 295.0 COG0812@1|root,COG0812@2|Bacteria,3Y3AT@57723|Acidobacteria,2JIMJ@204432|Acidobacteriia 204432|Acidobacteriia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C GZD1_k127_535565_4 1267535.KB906767_gene2168 1.559e-214 691.0 COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria,2JMHB@204432|Acidobacteriia 204432|Acidobacteriia C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K00256 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 GZD1_k127_535565_19 1254432.SCE1572_15840 3.628e-44 166.0 COG2080@1|root,COG2080@2|Bacteria,1MY3F@1224|Proteobacteria,43AH3@68525|delta/epsilon subdivisions,2X5X3@28221|Deltaproteobacteria,2YV94@29|Myxococcales 28221|Deltaproteobacteria C [2Fe-2S] binding domain - - - ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002 - - - Fer2,Fer2_2 GZD1_k127_535565_12 765420.OSCT_1304 3.76e-57 210.0 COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi,375H1@32061|Chloroflexia 32061|Chloroflexia H Belongs to the NadC ModD family - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N GZD1_k127_535565_9 867845.KI911784_gene1507 1.318e-113 376.0 COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi,375TJ@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA GZD1_k127_535565_15 1123508.JH636452_gene6908 5.433e-55 199.0 COG2128@1|root,COG2128@2|Bacteria,2IZ92@203682|Planctomycetes 203682|Planctomycetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD GZD1_k127_535565_2 240015.ACP_3514 4.25e-246 788.0 COG0577@1|root,COG0577@2|Bacteria,3Y6R1@57723|Acidobacteria,2JMKX@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_535565_17 1267535.KB906767_gene1123 9.667e-49 176.0 COG1695@1|root,COG1695@2|Bacteria,3Y55J@57723|Acidobacteria,2JJQ9@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR GZD1_k127_535565_3 378806.STAUR_3846 8.066e-225 706.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,43BWY@68525|delta/epsilon subdivisions,2X77Q@28221|Deltaproteobacteria,2YXSH@29|Myxococcales 28221|Deltaproteobacteria E Glutamine synthetase, beta-Grasp domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N GZD1_k127_535565_1 580332.Slit_2525 7.402e-263 828.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2VHBN@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM Glycoside hydrolase 15-related - - - - - - - - - - - - Glyco_hydro_15 GZD1_k127_535565_13 580332.Slit_2524 4.081e-57 222.0 COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria 28216|Betaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase GZD1_k127_535565_0 330214.NIDE0144 1.571e-287 903.0 COG0380@1|root,COG0380@2|Bacteria,3J109@40117|Nitrospirae 40117|Nitrospirae M Glycosyltransferase family 20 - - 2.4.1.15,2.4.1.347 ko:K00697 ko00500,ko01100,map00500,map01100 - R02737 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20 GZD1_k127_535565_8 1265310.CCBD010000065_gene939 4.036e-131 441.0 COG0515@1|root,COG2199@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,2H5ZS@201174|Actinobacteria,232IX@1762|Mycobacteriaceae 2|Bacteria KLT PFAM Protein kinase cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheX,HATPase_c,HisKA,Response_reg GZD1_k127_535565_18 195250.CM001776_gene1466 2.839e-48 183.0 COG0745@1|root,COG0745@2|Bacteria,1G6W5@1117|Cyanobacteria,1H0QZ@1129|Synechococcus 1117|Cyanobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg GZD1_k127_535565_10 1173027.Mic7113_4161 3.399e-86 311.0 COG2199@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1GQ1T@1117|Cyanobacteria,1HHSH@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,Response_reg GZD1_k127_535565_16 1121904.ARBP01000028_gene1652 2.824e-49 187.0 COG2194@1|root,COG2194@2|Bacteria 2|Bacteria T sulfuric ester hydrolase activity kbaA GO:0008150,GO:0022603,GO:0042173,GO:0043937,GO:0043938,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 2.7.8.43 ko:K03760,ko:K06349,ko:K19353 ko00540,ko01503,map00540,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,KbaA,Sulfatase GZD1_k127_5359224_0 1385515.N791_02545 5.41e-132 439.0 COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,1RYHQ@1236|Gammaproteobacteria,1X2XJ@135614|Xanthomonadales 135614|Xanthomonadales S Peptidase m28 - - - - - - - - - - - - Peptidase_M28 GZD1_k127_5359224_3 1232410.KI421428_gene1003 1.092e-79 280.0 COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,42RXX@68525|delta/epsilon subdivisions,2WNME@28221|Deltaproteobacteria,43TKF@69541|Desulfuromonadales 28221|Deltaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF GZD1_k127_5359224_13 861299.J421_5835 4.003e-06 50.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB GZD1_k127_5359224_4 1134445.AJJM01000003_gene3396 1.73e-57 206.0 COG1670@1|root,COG1670@2|Bacteria,2IQ5X@201174|Actinobacteria 201174|Actinobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 GZD1_k127_5359224_2 861299.J421_0626 5.359e-105 347.0 COG2819@1|root,COG2819@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - ko:K07017 - - - - ko00000 - - - Esterase GZD1_k127_5359224_11 446470.Snas_2285 2.96e-14 78.0 2EGRJ@1|root,33AHR@2|Bacteria,2GY62@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF1761) - - - - - - - - - - - - DUF1761 GZD1_k127_5359224_8 697282.Mettu_2125 8.798e-39 151.0 COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,1S9PQ@1236|Gammaproteobacteria,1XFRK@135618|Methylococcales 135618|Methylococcales S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 GZD1_k127_5359224_10 1122138.AQUZ01000079_gene5618 4.824e-18 86.0 COG3813@1|root,COG3813@2|Bacteria,2GRIY@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF1272) - - - ko:K09984 - - - - ko00000 - - - DUF1272 GZD1_k127_5359224_6 1227739.Hsw_PA0090 5.117e-53 194.0 COG3631@1|root,COG3631@2|Bacteria,4NP0M@976|Bacteroidetes 976|Bacteroidetes S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL GZD1_k127_5359224_9 224911.27349067 4.365e-38 152.0 2CDHC@1|root,30KXA@2|Bacteria,1PT2N@1224|Proteobacteria,2UANN@28211|Alphaproteobacteria,3K6B4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_5359224_7 1054213.HMPREF9946_02362 1.138e-50 196.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2U70V@28211|Alphaproteobacteria,2JT1J@204441|Rhodospirillales 204441|Rhodospirillales S Appr-1'-p processing enzyme - - - - - - - - - - - - Macro GZD1_k127_5359224_1 1198114.AciX9_1598 8.938e-125 409.0 COG0657@1|root,COG0657@2|Bacteria,3Y62J@57723|Acidobacteria,2JM4E@204432|Acidobacteriia 204432|Acidobacteriia I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 GZD1_k127_5359224_14 485915.Dret_2476 1.508e-05 51.0 COG3136@1|root,COG3136@2|Bacteria 2|Bacteria S membrane protein required for alginate biosynthesis ydgC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02442 - - - - ko00000 - - - GlpM GZD1_k127_5364518_4 861299.J421_3420 1.115e-110 362.0 COG0539@1|root,COG0539@2|Bacteria,1ZSKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 GZD1_k127_5364518_8 1114970.PSF113_1641 9.083e-41 162.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1YPI1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1391,iSDY_1059.SDY_2348 Cytidylate_kin GZD1_k127_5364518_5 861299.J421_3422 2.945e-105 355.0 COG0128@1|root,COG0128@2|Bacteria 2|Bacteria E 3-phosphoshikimate 1-carboxyvinyltransferase activity aroA GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_0998,iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829,iPC815.YPO1390 EPSP_synthase GZD1_k127_5364518_12 234267.Acid_3295 6.984e-08 64.0 COG2373@1|root,COG3386@1|root,COG2373@2|Bacteria,COG3386@2|Bacteria,3Y3S3@57723|Acidobacteria 57723|Acidobacteria G PFAM NHL repeat containing protein - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - Big_1,Big_3_5,NHL GZD1_k127_5364518_2 861299.J421_4135 8.95e-181 597.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_5364518_9 469383.Cwoe_3737 5.585e-35 151.0 COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4CQPM@84995|Rubrobacteria 84995|Rubrobacteria E Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDH GZD1_k127_5364518_10 1172188.KB911822_gene708 1.083e-17 87.0 COG0745@1|root,COG0745@2|Bacteria,2IS52@201174|Actinobacteria,4FH4M@85021|Intrasporangiaceae 201174|Actinobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg GZD1_k127_5364518_11 861299.J421_5781 3.716e-12 78.0 COG3595@1|root,COG3595@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4097 GZD1_k127_5364518_3 1379270.AUXF01000005_gene642 3.596e-119 412.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_5364518_7 441620.Mpop_0499 3.212e-42 159.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,1JV4E@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX GZD1_k127_5364518_1 1265505.ATUG01000001_gene3215 8.39e-187 601.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C GZD1_k127_5364518_6 1122179.KB890426_gene3974 8.081e-67 243.0 COG0300@1|root,COG0300@2|Bacteria,4NEMK@976|Bacteroidetes,1IS4Y@117747|Sphingobacteriia 976|Bacteroidetes S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short GZD1_k127_5364518_0 518766.Rmar_0395 4.201e-199 640.0 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes,1FIJ4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 GZD1_k127_5364518_13 1379270.AUXF01000001_gene2516 1.912e-05 56.0 COG0810@1|root,COG0810@2|Bacteria,1ZSVC@142182|Gemmatimonadetes 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C GZD1_k127_5383673_2 1379270.AUXF01000004_gene3143 2.226e-101 342.0 COG1774@1|root,COG1774@2|Bacteria,1ZTE8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S PSP1 C-terminal conserved region - - - - - - - - - - - - PSP1 GZD1_k127_5383673_1 1379270.AUXF01000004_gene3142 1.567e-127 416.0 COG0825@1|root,COG0825@2|Bacteria,1ZSW6@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA GZD1_k127_5383673_0 1379698.RBG1_1C00001G0460 1.314e-302 966.0 COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria 2|Bacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon GZD1_k127_5419986_39 266834.SM_b20905 1.433e-10 61.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,4BC7V@82115|Rhizobiaceae 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,rve,rve_3 GZD1_k127_5419986_34 373903.Hore_05950 5.095e-34 147.0 COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,3WBNJ@53433|Halanaerobiales 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA GZD1_k127_5419986_1 861299.J421_3780 0.0 1146.0 COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran GZD1_k127_5419986_35 448385.sce5866 2.869e-21 106.0 COG0392@1|root,COG0392@2|Bacteria,1R959@1224|Proteobacteria 1224|Proteobacteria S integral membrane protein - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GZD1_k127_5419986_37 1278073.MYSTI_03579 6.084e-16 91.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,42S8N@68525|delta/epsilon subdivisions,2WNCI@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Forkhead associated domain - - - - - - - - - - - - FHA,Yop-YscD_cpl GZD1_k127_5419986_18 1379270.AUXF01000003_gene3674 4.344e-86 291.0 COG0631@1|root,COG0631@2|Bacteria,1ZSYG@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 GZD1_k127_5419986_9 861299.J421_3775 1.361e-127 427.0 COG1078@1|root,COG1078@2|Bacteria,1ZT3F@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD GZD1_k127_5419986_5 861299.J421_3772 1.187e-232 732.0 COG1866@1|root,COG1866@2|Bacteria,1ZSTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP GZD1_k127_5419986_3 945713.IALB_1797 7.276e-271 853.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria 2|Bacteria C malic enzyme maeB GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 ko:K00027,ko:K00029,ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 M00169,M00172,M00357,M00579 R00214,R00216,R00230,R00921 RC00004,RC00105,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic GZD1_k127_5419986_0 1163407.UU7_08493 0.0 1441.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1RNST@1236|Gammaproteobacteria,1XCEU@135614|Xanthomonadales 135614|Xanthomonadales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran GZD1_k127_5419986_23 1267535.KB906767_gene2835 2.043e-78 279.0 COG0845@1|root,COG0845@2|Bacteria,3Y47H@57723|Acidobacteria,2JI8J@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 GZD1_k127_5419986_14 861299.J421_3764 8.205e-98 335.0 COG1538@1|root,COG1538@2|Bacteria,1ZV8X@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP GZD1_k127_5419986_21 861299.J421_3762 1.087e-84 298.0 COG0648@1|root,COG0648@2|Bacteria,1ZSY0@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 GZD1_k127_5419986_31 456442.Mboo_0258 8.058e-51 208.0 COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,2N9U4@224756|Methanomicrobia 224756|Methanomicrobia J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT GZD1_k127_5419986_27 379066.GAU_0485 1.7e-66 253.0 COG0745@1|root,COG2199@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1ZT7F@142182|Gemmatimonadetes 142182|Gemmatimonadetes T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg GZD1_k127_5419986_13 696281.Desru_2505 7.27e-105 354.0 COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,261AQ@186807|Peptococcaceae 186801|Clostridia U PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 GZD1_k127_5419986_17 1379270.AUXF01000002_gene1712 1.044e-87 309.0 COG1131@1|root,COG1131@2|Bacteria,1ZTMK@142182|Gemmatimonadetes 142182|Gemmatimonadetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_5419986_32 379066.GAU_0376 1.975e-47 188.0 COG0845@1|root,COG0845@2|Bacteria,1ZUTG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 GZD1_k127_5419986_36 596151.DesfrDRAFT_1139 1.573e-17 90.0 COG1309@1|root,COG1309@2|Bacteria,1RCDH@1224|Proteobacteria,42VJ5@68525|delta/epsilon subdivisions,2WRC7@28221|Deltaproteobacteria,2M821@213115|Desulfovibrionales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_3,TetR_N GZD1_k127_5419986_25 861299.J421_3761 2.385e-75 269.0 COG4942@1|root,COG4942@2|Bacteria,1ZSU6@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 GZD1_k127_5419986_24 861299.J421_3760 4.905e-76 265.0 COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Part of the ABC transporter FtsEX involved in - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - GZD1_k127_5419986_22 861299.J421_3759 9.454e-82 277.0 COG2884@1|root,COG2884@2|Bacteria,1ZTHQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D ABC transporter - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran GZD1_k127_5419986_8 861299.J421_3758 1.891e-142 469.0 COG0626@1|root,COG0626@2|Bacteria,1ZUSY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Cys/Met metabolism PLP-dependent enzyme - - - - - - - - - - - - Cys_Met_Meta_PP GZD1_k127_5419986_38 861299.J421_3756 3.001e-14 78.0 2EFCU@1|root,3395Q@2|Bacteria,1ZTVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5419986_15 861299.J421_3755 4.475e-96 323.0 COG0643@1|root,COG0643@2|Bacteria,1ZSPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Histidine kinase-like ATPases - - - - - - - - - - - - - GZD1_k127_5419986_20 379066.GAU_2155 4.362e-85 293.0 COG0524@1|root,COG0524@2|Bacteria,1ZTFD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - - - - - - - - - - - GZD1_k127_5419986_10 861299.J421_3753 1.53e-122 400.0 COG1940@1|root,COG1940@2|Bacteria,1ZT66@142182|Gemmatimonadetes 142182|Gemmatimonadetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK GZD1_k127_5419986_33 880073.Calab_1590 4.82e-43 171.0 COG0859@1|root,COG0859@2|Bacteria,2NP5P@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferase, family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 GZD1_k127_5419986_4 340177.Cag_0490 4.214e-243 764.0 COG0481@1|root,COG0481@2|Bacteria,1FDSU@1090|Chlorobi 1090|Chlorobi J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C GZD1_k127_5419986_12 379066.GAU_0446 9.76e-113 378.0 COG1158@1|root,COG1158@2|Bacteria,1ZTA0@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_RNA_bind GZD1_k127_5419986_19 861299.J421_3749 5.621e-86 293.0 COG1721@1|root,COG1721@2|Bacteria,1ZT0H@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 GZD1_k127_5419986_29 1379270.AUXF01000003_gene3697 3.515e-56 217.0 COG2304@1|root,COG2304@2|Bacteria,1ZT05@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA GZD1_k127_5419986_6 1121468.AUBR01000069_gene1116 1.81e-224 737.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,42EQJ@68295|Thermoanaerobacterales 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF GZD1_k127_5419986_30 861299.J421_3746 1.026e-55 215.0 COG0760@1|root,COG0760@2|Bacteria,1ZT5S@142182|Gemmatimonadetes 142182|Gemmatimonadetes M PPIC-type PPIASE domain - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 GZD1_k127_5419986_26 861299.J421_3745 8.261e-75 267.0 COG0760@1|root,COG0760@2|Bacteria,1ZSU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes O SurA N-terminal domain - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3,SurA_N_3 GZD1_k127_5419986_16 861299.J421_3744 2.67e-94 319.0 COG1995@1|root,COG1995@2|Bacteria,1ZT2S@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyridoxal phosphate biosynthetic protein PdxA - - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA GZD1_k127_5419986_11 861299.J421_3989 7.459e-118 393.0 COG1253@1|root,COG1253@2|Bacteria,1ZT0D@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 GZD1_k127_5419986_28 1489678.RDMS_12985 5.6e-66 255.0 COG1230@1|root,COG1230@2|Bacteria 2|Bacteria P cation diffusion facilitator family transporter zitB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - iNRG857_1313.NRG857_03325,iPC815.YPO1129 Cation_efflux,ZT_dimer GZD1_k127_5419986_2 1379270.AUXF01000003_gene3703 6.117e-273 854.0 COG1217@1|root,COG1217@2|Bacteria,1ZT8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Elongation factor G C-terminus - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 GZD1_k127_5419986_7 1379270.AUXF01000001_gene2292 6.938e-198 636.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - - - - - - - - - - - Beta_helix,NosD GZD1_k127_5539355_49 1379698.RBG1_1C00001G0252 1.277e-22 100.0 COG2323@1|root,COG2323@2|Bacteria,2NR09@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF421) - - - - - - - - - - - - DUF421 GZD1_k127_5539355_33 266264.Rmet_5010 4.7e-58 217.0 COG4430@1|root,COG4430@2|Bacteria,1NEN6@1224|Proteobacteria,2VI9Z@28216|Betaproteobacteria,1K8P9@119060|Burkholderiaceae 28216|Betaproteobacteria S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - OmdA GZD1_k127_5539355_37 861299.J421_2258 5.634e-50 186.0 COG0394@1|root,COG0394@2|Bacteria 2|Bacteria T Belongs to the low molecular weight phosphotyrosine protein phosphatase family arsC2 - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc GZD1_k127_5539355_5 379066.GAU_0705 7.171e-157 510.0 COG0798@1|root,COG0798@2|Bacteria 2|Bacteria P PFAM Bile acid sodium symporter arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - ko:K03325 - - - - ko00000,ko02000 2.A.59 - iYO844.BSU25790 SBF GZD1_k127_5539355_12 1267535.KB906767_gene5005 1.561e-108 357.0 COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria 57723|Acidobacteria Q Hypothetical methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 GZD1_k127_5539355_45 861299.J421_2255 1.372e-31 126.0 COG0640@1|root,COG0640@2|Bacteria,1ZV07@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 GZD1_k127_5539355_43 379066.GAU_3774 6.685e-39 152.0 COG3019@1|root,COG3019@2|Bacteria,1ZTWW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 GZD1_k127_5539355_42 861299.J421_1313 1.409e-43 169.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - - ko:K10914,ko:K21563 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding GZD1_k127_5539355_31 204669.Acid345_0491 5.263e-66 230.0 2DWTZ@1|root,341V1@2|Bacteria,3Y8BR@57723|Acidobacteria,2JN8Z@204432|Acidobacteriia 204432|Acidobacteriia S DoxX - - 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxX GZD1_k127_5539355_47 512565.AMIS_9560 1.38e-27 115.0 COG0596@1|root,COG0596@2|Bacteria,2GU04@201174|Actinobacteria 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - - GZD1_k127_5539355_40 1121035.AUCH01000005_gene125 4.847e-46 178.0 COG2199@1|root,COG3706@2|Bacteria,1MYK0@1224|Proteobacteria 1224|Proteobacteria T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg GZD1_k127_5539355_11 1162668.LFE_2306 6.898e-110 380.0 COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,3J12S@40117|Nitrospirae 40117|Nitrospirae T CHASE3 domain - - - - - - - - - - - - CHASE3,HATPase_c,HisKA GZD1_k127_5539355_39 580332.Slit_1329 6.05e-48 190.0 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2WGQ0@28216|Betaproteobacteria 28216|Betaproteobacteria T response regulator - - - ko:K02485 - - - - ko00000,ko02022 - - - Response_reg GZD1_k127_5539355_6 525904.Tter_0212 4.487e-152 494.0 COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria 2|Bacteria C Belongs to the aldehyde dehydrogenase family - - - ko:K22187 ko00040,map00040 - R11768 RC00080 ko00000,ko00001,ko01000 - - - Aldedh GZD1_k127_5539355_13 240015.ACP_3275 2.528e-108 367.0 COG3938@1|root,COG3938@2|Bacteria,3Y6TR@57723|Acidobacteria,2JKPS@204432|Acidobacteriia 204432|Acidobacteriia E Proline racemase - - 5.1.1.8 ko:K12658 ko00330,map00330 - R03296 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase GZD1_k127_5539355_19 1121381.JNIV01000005_gene2594 1.902e-98 342.0 COG0665@1|root,COG0665@2|Bacteria 2|Bacteria E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - ko:K21061 ko00330,map00330 - R11428 RC00135 ko00000,ko00001,ko01000 - - - DAO GZD1_k127_5539355_50 1442599.JAAN01000036_gene543 3.777e-17 92.0 COG1034@1|root,COG1034@2|Bacteria,1N72X@1224|Proteobacteria,1T35I@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_4 GZD1_k127_5539355_21 1382359.JIAL01000001_gene533 1.548e-92 322.0 COG0446@1|root,COG0446@2|Bacteria,3Y6DC@57723|Acidobacteria,2JM97@204432|Acidobacteriia 204432|Acidobacteriia C FAD dependent oxidoreductase - - - - - - - - - - - - Pyr_redox_2 GZD1_k127_5539355_15 1267535.KB906767_gene3115 2.226e-106 357.0 COG0329@1|root,COG0329@2|Bacteria 2|Bacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA2 - 3.5.4.22,4.3.3.7 ko:K01714,ko:K21062 ko00261,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00330,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R02280,R10147 RC00679,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS GZD1_k127_5539355_3 379066.GAU_2299 3.747e-189 607.0 COG4805@1|root,COG4805@2|Bacteria,1ZUMK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 GZD1_k127_5539355_44 530564.Psta_0758 2.847e-37 145.0 COG2318@1|root,COG2318@2|Bacteria,2J1JI@203682|Planctomycetes 203682|Planctomycetes S DinB family - - - - - - - - - - - - DinB GZD1_k127_5539355_35 1173025.GEI7407_0742 3.178e-54 212.0 COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria,1H7J1@1150|Oscillatoriales 1117|Cyanobacteria S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 GZD1_k127_5539355_24 861299.J421_6133 2.96e-83 285.0 COG0189@1|root,COG0189@2|Bacteria 2|Bacteria HJ Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) dcsG - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,RimK GZD1_k127_5539355_8 234267.Acid_6173 8.293e-140 468.0 COG1741@1|root,COG1741@2|Bacteria,3Y367@57723|Acidobacteria 57723|Acidobacteria S Pirin C-terminal cupin domain - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C GZD1_k127_5539355_34 1298858.AUEL01000011_gene5524 7.557e-56 201.0 COG2020@1|root,COG2020@2|Bacteria,1MXP9@1224|Proteobacteria,2U2A4@28211|Alphaproteobacteria,43MDZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O PFAM Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT,PEMT GZD1_k127_5539355_7 642227.HA49_17415 1.498e-149 483.0 COG2042@1|root,COG3376@2|Bacteria,1MUYH@1224|Proteobacteria,1RQM1@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the NiCoT transporter (TC 2.A.52) family hoxN - - ko:K07241 - - - - ko00000,ko02000 2.A.52.1 - - NicO GZD1_k127_5539355_38 1173026.Glo7428_0621 2.136e-49 184.0 COG1670@1|root,COG1670@2|Bacteria,1G634@1117|Cyanobacteria 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 GZD1_k127_5539355_36 861299.J421_1097 4.247e-53 192.0 COG2318@1|root,COG2318@2|Bacteria,1ZV4X@142182|Gemmatimonadetes 2|Bacteria S DinB family - - - - - - - - - - - - DinB,DinB_2 GZD1_k127_5539355_30 479434.Sthe_2969 6.712e-67 232.0 COG0262@1|root,COG0262@2|Bacteria,2G8M0@200795|Chloroflexi 200795|Chloroflexi H PFAM bifunctional deaminase-reductase domain protein - - - - - - - - - - - - RibD_C GZD1_k127_5539355_27 1459636.NTE_00013 4.796e-75 258.0 COG2085@1|root,arCOG00457@2157|Archaea 2157|Archaea S NADPH-dependent F420 reductase - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored,HTH_10 GZD1_k127_5539355_10 661478.OP10G_2096 5.658e-112 382.0 COG2866@1|root,COG2866@2|Bacteria 2|Bacteria E metallocarboxypeptidase activity - - - - - - - - - - - - Peptidase_M14 GZD1_k127_5539355_51 392499.Swit_1895 5.81e-16 85.0 2AEG6@1|root,314B9@2|Bacteria,1NMR1@1224|Proteobacteria,2UU1S@28211|Alphaproteobacteria,2K71V@204457|Sphingomonadales 204457|Sphingomonadales S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 GZD1_k127_5539355_1 926566.Terro_2899 2.381e-230 730.0 COG2303@1|root,COG2303@2|Bacteria,3Y6FS@57723|Acidobacteria,2JM7Q@204432|Acidobacteriia 204432|Acidobacteriia E GMC oxidoreductase - - - - - - - - - - - - - GZD1_k127_5539355_28 518766.Rmar_1735 5.101e-71 255.0 COG1082@1|root,COG1082@2|Bacteria,4NJ3Z@976|Bacteroidetes,1FJUS@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 GZD1_k127_5539355_17 1254432.SCE1572_47310 3.118e-101 364.0 COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales 28221|Deltaproteobacteria K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc GZD1_k127_5539355_4 861299.J421_1230 1.37e-182 607.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_1230|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - GZD1_k127_5539355_23 861299.J421_2407 2.555e-83 288.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1ZT3S@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C GZD1_k127_5539355_2 485913.Krac_7161 1.713e-212 676.0 COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi 200795|Chloroflexi C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 GZD1_k127_5539355_29 649638.Trad_2804 1.046e-67 237.0 COG1845@1|root,COG1845@2|Bacteria,1WJ6Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C COGs COG1845 Heme copper-type cytochrome quinol oxidase subunit 3 - - 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 GZD1_k127_5539355_52 479434.Sthe_1585 1.244e-15 80.0 2EKS3@1|root,33EFV@2|Bacteria,2GBBM@200795|Chloroflexi,27YP9@189775|Thermomicrobia 189775|Thermomicrobia S Prokaryotic Cytochrome C oxidase subunit IV - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - COX4_pro GZD1_k127_5539355_26 861299.J421_2411 5.186e-78 283.0 COG3336@1|root,COG3336@2|Bacteria,1ZT56@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - - - - - - - - - - Caa3_CtaG GZD1_k127_5539355_48 861299.J421_2404 5.509e-27 119.0 2DW4B@1|root,33YGG@2|Bacteria,1ZV12@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5539355_9 861299.J421_3849 1.961e-112 381.0 COG0265@1|root,COG0265@2|Bacteria,1ZTG6@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 GZD1_k127_5539355_0 861299.J421_3848 5e-324 1002.0 COG0443@1|root,COG0443@2|Bacteria,1ZT75@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 GZD1_k127_5539355_22 404589.Anae109_1579 1.616e-83 283.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2YVSU@29|Myxococcales 28221|Deltaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid GZD1_k127_5539355_32 379066.GAU_2370 2.253e-62 223.0 COG0704@1|root,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU GZD1_k127_5539355_18 349741.Amuc_1303 1.532e-98 340.0 COG1117@1|root,COG1117@2|Bacteria,46SB2@74201|Verrucomicrobia,2ITRC@203494|Verrucomicrobiae 203494|Verrucomicrobiae P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system - - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran GZD1_k127_5539355_20 644966.Tmar_1646 2.674e-98 327.0 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3WCRK@538999|Clostridiales incertae sedis 186801|Clostridia P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran GZD1_k127_5539355_25 1267533.KB906739_gene2672 6.951e-81 292.0 COG0581@1|root,COG0581@2|Bacteria,3Y3JF@57723|Acidobacteria,2JHVP@204432|Acidobacteriia 204432|Acidobacteriia P Phosphate transport system permease protein PstA - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 GZD1_k127_5539355_16 204669.Acid345_2974 2.084e-101 341.0 COG0573@1|root,COG0573@2|Bacteria,3Y42Y@57723|Acidobacteria,2JIJN@204432|Acidobacteriia 204432|Acidobacteriia P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 GZD1_k127_5539355_14 278963.ATWD01000001_gene4383 5.832e-107 357.0 COG0226@1|root,COG0226@2|Bacteria,3Y399@57723|Acidobacteria,2JIVU@204432|Acidobacteriia 204432|Acidobacteriia P Belongs to the PstS family - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 GZD1_k127_5539355_46 215803.DB30_8669 6.951e-30 132.0 29WT0@1|root,30IED@2|Bacteria,1PVH7@1224|Proteobacteria,432F6@68525|delta/epsilon subdivisions,2WY2D@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_554986_23 861299.J421_6360 3.071e-09 65.0 2F0M3@1|root,33TPR@2|Bacteria,1ZUAZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_554986_7 1379270.AUXF01000003_gene3394 1.01e-129 422.0 COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 GZD1_k127_554986_16 1379270.AUXF01000003_gene3395 9.792e-37 149.0 COG3166@1|root,COG3166@2|Bacteria,1ZTR8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Fimbrial assembly protein (PilN) - - - - - - - - - - - - PilN GZD1_k127_554986_24 713586.KB900536_gene1833 8.557e-08 61.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales 135613|Chromatiales NU Pilus assembly protein PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO GZD1_k127_554986_20 379066.GAU_2515 4.506e-20 105.0 2F6AC@1|root,33YU1@2|Bacteria,1ZTY6@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_554986_5 861299.J421_3976 5.683e-154 511.0 COG4796@1|root,COG4796@2|Bacteria,1ZSRT@142182|Gemmatimonadetes 142182|Gemmatimonadetes U AMIN domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,Secretin,Secretin_N GZD1_k127_554986_10 1379270.AUXF01000003_gene3399 7.114e-95 341.0 COG3391@1|root,COG3391@2|Bacteria,1ZT90@142182|Gemmatimonadetes 142182|Gemmatimonadetes S amine dehydrogenase activity - - - - - - - - - - - - - GZD1_k127_554986_4 379066.GAU_2512 1.504e-157 506.0 COG0082@1|root,COG0082@2|Bacteria,1ZT39@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt GZD1_k127_554986_19 861299.J421_3973 2.571e-24 119.0 COG0703@1|root,COG0703@2|Bacteria,1ZTXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI GZD1_k127_554986_0 743299.Acife_0011 9.423e-213 686.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,2NCIF@225057|Acidithiobacillales 225057|Acidithiobacillales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom GZD1_k127_554986_3 861299.J421_3968 3.574e-172 560.0 COG1206@1|root,COG1206@2|Bacteria,1ZTB8@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs gid - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA GZD1_k127_554986_9 861299.J421_3967 2.16e-99 338.0 COG4974@1|root,COG4974@2|Bacteria,1ZT3T@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Phage integrase, N-terminal SAM-like domain xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase GZD1_k127_554986_12 861299.J421_3964 1.128e-79 269.0 COG5405@1|root,COG5405@2|Bacteria,1ZSVH@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome GZD1_k127_554986_1 861299.J421_3962 3.99e-173 567.0 COG1220@1|root,COG1220@2|Bacteria,1ZSVP@142182|Gemmatimonadetes 142182|Gemmatimonadetes O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small GZD1_k127_554986_6 861299.J421_3960 9.827e-137 441.0 COG0078@1|root,COG0078@2|Bacteria,1ZT4K@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N GZD1_k127_554986_8 379066.GAU_2499 1.099e-126 415.0 COG0404@1|root,COG0404@2|Bacteria,1ZTBZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C GZD1_k127_554986_14 861299.J421_3956 9.11e-44 174.0 COG0521@1|root,COG0521@2|Bacteria,1ZU2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Probable molybdopterin binding domain - - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth GZD1_k127_554986_2 861299.J421_3955 2.543e-172 554.0 COG2204@1|root,COG2204@2|Bacteria,1ZSWY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat GZD1_k127_554986_11 1379698.RBG1_1C00001G0290 5.988e-93 336.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 GZD1_k127_554986_18 196367.JNFG01000199_gene3304 2.419e-30 138.0 COG2199@1|root,COG3706@2|Bacteria,1RF2E@1224|Proteobacteria,2VS5I@28216|Betaproteobacteria,1KA0P@119060|Burkholderiaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_9 GZD1_k127_554986_15 861299.J421_3954 1.169e-38 154.0 2C0MY@1|root,30KW5@2|Bacteria,1ZTVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_554986_22 665571.STHERM_c20110 8.23e-18 91.0 COG0745@1|root,COG0745@2|Bacteria,2J7NK@203691|Spirochaetes 203691|Spirochaetes T Response regulator receiver domain - - - - - - - - - - - - HTH_17,Response_reg GZD1_k127_554986_13 379066.GAU_2496 1.315e-72 262.0 COG3437@1|root,COG3437@2|Bacteria,1ZUP1@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT HD domain - - - - - - - - - - - - - GZD1_k127_554986_17 1380390.JIAT01000009_gene1032 7.057e-36 159.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2GM4U@201174|Actinobacteria 201174|Actinobacteria T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD GZD1_k127_554986_21 861299.J421_3986 9.855e-20 91.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE - - ko:K02456,ko:K02650,ko:K02655 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - ComP_DUS,N_methyl GZD1_k127_5606027_4 1379270.AUXF01000006_gene124 3.708e-46 186.0 COG4589@1|root,COG4589@2|Bacteria,1ZTGH@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Cytidylyltransferase family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 GZD1_k127_5606027_0 861299.J421_3408 4.012e-102 338.0 COG0020@1|root,COG0020@2|Bacteria,1ZSNJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids - - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf GZD1_k127_5606027_3 861299.J421_3409 3.483e-63 233.0 COG0233@1|root,COG0233@2|Bacteria,1ZTI2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF GZD1_k127_5606027_1 1379270.AUXF01000006_gene121 3.128e-90 304.0 COG0528@1|root,COG0528@2|Bacteria,1ZSY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase GZD1_k127_5606027_2 477974.Daud_0607 2.642e-66 233.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,260PI@186807|Peptococcaceae 186801|Clostridia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS GZD1_k127_5606027_5 1379270.AUXF01000006_gene119 6.638e-36 140.0 COG0052@1|root,COG0052@2|Bacteria,1ZSNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S2 rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 GZD1_k127_5610226_6 861299.J421_1666 2.931e-98 344.0 COG0515@1|root,COG0515@2|Bacteria,1ZUM6@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_5610226_7 322710.Avin_44380 1.984e-96 322.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,1RN80@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Aspartyl Asparaginyl beta-hydroxylase - - - - - - - - - - - - Asp_Arg_Hydrox GZD1_k127_5610226_17 595460.RRSWK_05717 6.114e-12 78.0 COG0859@1|root,COG0859@2|Bacteria,2IYZS@203682|Planctomycetes 203682|Planctomycetes M COG0859 ADP-heptose LPS heptosyltransferase - - - ko:K02841,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 GZD1_k127_5610226_2 861299.J421_1512 1.24e-124 411.0 COG2270@1|root,COG2270@2|Bacteria 2|Bacteria G Major facilitator Superfamily cmr - 2.7.4.9 ko:K00943,ko:K08217,ko:K18833 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.2,2.A.1.21.22 - - MFS_1,MFS_3 GZD1_k127_5610226_16 1288079.AUKN01000018_gene2521 5.373e-12 78.0 COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria 201174|Actinobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Cupin_3 GZD1_k127_5610226_1 1122604.JONR01000005_gene939 1.073e-125 419.0 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,1RNQB@1236|Gammaproteobacteria,1X4AJ@135614|Xanthomonadales 135614|Xanthomonadales K AlkA N-terminal domain Ada - 3.2.2.21 ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD GZD1_k127_5610226_13 1121930.AQXG01000011_gene1705 4.403e-16 93.0 COG1470@1|root,COG1470@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - CarbopepD_reg_2 GZD1_k127_5610226_3 483219.LILAB_29135 6.113e-120 397.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_5610226_15 379066.GAU_3799 3.932e-12 77.0 COG0392@1|root,COG0392@2|Bacteria,1ZSUQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GZD1_k127_5610226_14 711393.AYRX01000070_gene734 5.097e-16 91.0 COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria 201174|Actinobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 GZD1_k127_5610226_9 1121013.P873_12075 7.887e-59 226.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_5610226_10 1280949.HAD_06095 3.517e-40 169.0 COG3394@1|root,COG3394@2|Bacteria,1PP39@1224|Proteobacteria,2U2UW@28211|Alphaproteobacteria 28211|Alphaproteobacteria G hopanoid biosynthesis associated protein HpnK - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC GZD1_k127_5610226_8 322710.Avin_44380 1.385e-95 319.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,1RN80@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Aspartyl Asparaginyl beta-hydroxylase - - - - - - - - - - - - Asp_Arg_Hydrox GZD1_k127_5610226_0 1267533.KB906736_gene917 3.186e-168 540.0 COG1228@1|root,COG1228@2|Bacteria,3Y2MZ@57723|Acidobacteria,2JI4B@204432|Acidobacteriia 204432|Acidobacteriia Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 GZD1_k127_5610226_12 1000565.METUNv1_03628 2.512e-16 91.0 28TB7@1|root,2ZFJR@2|Bacteria,1PACM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - GZD1_k127_5610226_20 1238182.C882_1453 0.0003408 51.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2TVHI@28211|Alphaproteobacteria,2JR2P@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 GZD1_k127_5610226_19 330214.NIDE0819 0.0003258 53.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety omp-1X - - ko:K12976,ko:K22110 - - - - ko00000,ko01000,ko01005,ko02000 1.B.35.1,1.B.35.2 - - DUF2490,OMP_b-brl,Surface_Ag_2 GZD1_k127_5610226_5 330214.NIDE3889 9.769e-103 355.0 COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3J0Q6@40117|Nitrospirae 2|Bacteria C Cytochrome b/b6/petB qcrC - - ko:K00412,ko:K03888 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B,Cytochrome_CBB3 GZD1_k127_5610226_11 330214.NIDE3890 7.31e-29 122.0 COG0723@1|root,COG0723@2|Bacteria,3J0TT@40117|Nitrospirae 40117|Nitrospirae C Rieske [2Fe-2S] domain - - 1.10.9.1 ko:K02636,ko:K03886 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00151,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - - Rieske GZD1_k127_5610226_4 316067.Geob_1847 2.153e-115 394.0 COG3437@1|root,COG3852@1|root,COG4191@1|root,COG3437@2|Bacteria,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X7PG@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg GZD1_k127_5618619_3 1379270.AUXF01000006_gene129 1.483e-29 119.0 COG0184@1|root,COG0184@2|Bacteria,1ZU0C@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 GZD1_k127_5618619_1 379066.GAU_1766 4.465e-77 269.0 COG0515@1|root,COG0515@2|Bacteria,1ZTE2@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_5618619_2 1123368.AUIS01000001_gene2043 1.599e-63 235.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,2NC9P@225057|Acidithiobacillales 225057|Acidithiobacillales M Peptidase family M50 - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Peptidase_M50 GZD1_k127_5618619_0 861299.J421_3406 4.636e-133 434.0 COG0743@1|root,COG0743@2|Bacteria,1ZTFR@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom GZD1_k127_5699281_16 861299.J421_3537 1.934e-09 67.0 COG0457@1|root,COG0457@2|Bacteria,1ZTTU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 GZD1_k127_5699281_9 180281.CPCC7001_2498 2.094e-48 177.0 COG0757@1|root,COG0757@2|Bacteria,1GJQQ@1117|Cyanobacteria,22SQF@167375|Cyanobium 1117|Cyanobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II GZD1_k127_5699281_5 861299.J421_3535 1.321e-107 363.0 COG0006@1|root,COG0006@2|Bacteria,1ZSTY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Creatinase/Prolidase N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 GZD1_k127_5699281_12 861299.J421_3534 6.427e-33 133.0 COG0511@1|root,COG0511@2|Bacteria,1ZTR1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl GZD1_k127_5699281_3 1379270.AUXF01000006_gene35 1.881e-155 501.0 COG2805@1|root,COG2805@2|Bacteria,1ZU8X@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE GZD1_k127_5699281_1 562970.Btus_0729 2.712e-177 582.0 COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HARK@91061|Bacilli,277WZ@186823|Alicyclobacillaceae 91061|Bacilli I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 GZD1_k127_5699281_10 861299.J421_3532 3.524e-44 171.0 COG2045@1|root,COG2045@2|Bacteria,1ZTM8@142182|Gemmatimonadetes 142182|Gemmatimonadetes H 2-phosphosulpholactate phosphatase comB - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp GZD1_k127_5699281_4 1449336.JQLO01000001_gene516 6.868e-129 439.0 COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,4H9WA@91061|Bacilli,27FD7@186828|Carnobacteriaceae 91061|Bacilli D Ftsk_gamma ftsK GO:0000003,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019954,GO:0030436,GO:0031323,GO:0031326,GO:0032502,GO:0043934,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma GZD1_k127_5699281_13 379066.GAU_1918 2.397e-30 124.0 COG0792@1|root,COG0792@2|Bacteria,1ZTWM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Uncharacterised protein family UPF0102 - - - ko:K07460 - - - - ko00000 - - - UPF0102 GZD1_k127_5699281_2 1379270.AUXF01000006_gene42 2.767e-173 550.0 COG0468@1|root,COG0468@2|Bacteria,1ZT78@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA GZD1_k127_5699281_15 1077144.AGFF01000023_gene1258 1.388e-09 68.0 COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria 201174|Actinobacteria S regulatory protein RecX recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03565 - - - - ko00000,ko03400 - - - RecX GZD1_k127_5699281_6 44060.JODL01000013_gene3888 2.76e-84 299.0 COG2072@1|root,COG2072@2|Bacteria,2GJWE@201174|Actinobacteria 201174|Actinobacteria P L-lysine 6-monooxygenase (NADPH-requiring) - - - - - - - - - - - - K_oxygenase,Pyr_redox_3 GZD1_k127_5699281_14 1197130.BAFM01000002_gene474 2.718e-30 134.0 COG3919@1|root,arCOG06897@2157|Archaea,2XUFQ@28890|Euryarchaeota,23U89@183963|Halobacteria 183963|Halobacteria S COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) - - - - - - - - - - - - ATP-grasp_3,CPSase_L_D2 GZD1_k127_5699281_0 1479237.JMLY01000001_gene2005 4.928e-226 732.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,465GZ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD GZD1_k127_5699281_17 861299.J421_3521 0.000607 47.0 2FKVD@1|root,34CFS@2|Bacteria,1ZV4C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5699281_11 880073.Calab_1998 1.103e-41 168.0 COG1646@1|root,COG1646@2|Bacteria,2NQW0@2323|unclassified Bacteria 2|Bacteria I PcrB family pcrB GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - ko:K07094 - - - - ko00000,ko01000 - - - PcrB GZD1_k127_5699281_8 861299.J421_3519 7.493e-57 205.0 COG0279@1|root,COG0279@2|Bacteria,1ZTY5@142182|Gemmatimonadetes 142182|Gemmatimonadetes G SIS domain - - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 GZD1_k127_5699281_7 379066.GAU_1912 1.609e-68 245.0 COG1028@1|root,COG1028@2|Bacteria,1ZTJK@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GZD1_k127_5837089_9 861299.J421_3270 2.807e-87 303.0 COG1028@1|root,COG1028@2|Bacteria,1ZT4H@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 GZD1_k127_5837089_10 379066.GAU_1638 5.333e-86 302.0 COG0331@1|root,COG0331@2|Bacteria,1ZT40@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl transferase domain - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 GZD1_k127_5837089_6 861299.J421_3272 2.625e-112 387.0 COG0332@1|root,COG0332@2|Bacteria,1ZSP4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C GZD1_k127_5837089_7 861299.J421_3273 7.752e-107 360.0 COG0416@1|root,COG0416@2|Bacteria,1ZSN4@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis GZD1_k127_5837089_19 1379270.AUXF01000006_gene249 5.991e-18 84.0 COG0333@1|root,COG0333@2|Bacteria,1ZU2M@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal L32p protein family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p GZD1_k127_5837089_15 861299.J421_3275 4.813e-43 163.0 COG1399@1|root,COG1399@2|Bacteria,1ZTSW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 GZD1_k127_5837089_14 1379270.AUXF01000006_gene247 2.916e-50 182.0 COG0105@1|root,COG0105@2|Bacteria,1ZTTD@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NDK - - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK GZD1_k127_5837089_13 861299.J421_3277 1.388e-57 214.0 COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria,1ZUGZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - - - - - - - - - - CBS,PTS_EIIA_2 GZD1_k127_5837089_5 1379270.AUXF01000006_gene246 1.224e-127 421.0 COG0074@1|root,COG0074@2|Bacteria,1ZT20@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA GZD1_k127_5837089_2 379066.GAU_1646 8.436e-153 501.0 COG0045@1|root,COG0045@2|Bacteria,1ZSZ4@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA GZD1_k127_5837089_12 368407.Memar_0247 5.796e-68 255.0 COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota 28890|Euryarchaeota E Belongs to the carbamate kinase family cpkA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase GZD1_k127_5837089_16 861299.J421_3280 3.659e-30 139.0 COG1615@1|root,COG1615@2|Bacteria,1ZTEE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 GZD1_k127_5837089_4 861299.J421_3281 2.151e-146 477.0 COG1109@1|root,COG1109@2|Bacteria,1ZSP6@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV GZD1_k127_5837089_8 861299.J421_3282 2.78e-106 367.0 COG1007@1|root,COG1007@2|Bacteria,1ZSVJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M GZD1_k127_5837089_1 1379698.RBG1_1C00001G1061 1.156e-164 535.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M GZD1_k127_5837089_0 861299.J421_3284 6.508e-232 734.0 COG1009@1|root,COG1009@2|Bacteria,1ZSZY@142182|Gemmatimonadetes 142182|Gemmatimonadetes CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N GZD1_k127_5837089_18 316067.Geob_0472 2.66e-25 117.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2WRE5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 GZD1_k127_5837089_17 861299.J421_3286 2.715e-28 127.0 COG0839@1|root,COG0839@2|Bacteria,1ZTSA@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 GZD1_k127_5837089_11 1379270.AUXF01000006_gene237 7.502e-80 287.0 COG1143@1|root,COG1143@2|Bacteria,1ZTHB@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4_7 GZD1_k127_5837089_3 379066.GAU_1655 6.653e-151 486.0 COG1005@1|root,COG1005@2|Bacteria,1ZTDY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh GZD1_k127_5914292_17 204669.Acid345_0518 1.051e-29 126.0 COG3794@1|root,COG3794@2|Bacteria,3Y4UD@57723|Acidobacteria,2JJH0@204432|Acidobacteriia 204432|Acidobacteriia C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - GZD1_k127_5914292_2 861299.J421_4439 6.482e-127 431.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_4439|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - GZD1_k127_5914292_10 1278073.MYSTI_00142 6.549e-63 224.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria 1224|Proteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - - - - - - - - - - Oxidored_molyb GZD1_k127_5914292_12 861299.J421_0327 2.298e-58 210.0 COG4117@1|root,COG4117@2|Bacteria,1ZUUH@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB GZD1_k127_5914292_1 264732.Moth_1224 4.737e-133 442.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,42I6D@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 GZD1_k127_5914292_0 861299.J421_6111 1.775e-187 611.0 COG2091@1|root,COG2091@2|Bacteria,1ZUKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - GZD1_k127_5914292_3 1278073.MYSTI_03750 1.951e-126 429.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_5914292_8 861299.J421_1982 1.551e-70 263.0 COG0845@1|root,COG0845@2|Bacteria,1ZU07@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 GZD1_k127_5914292_5 379066.GAU_1146 3.586e-96 340.0 COG1136@1|root,COG1136@2|Bacteria,1ZSKH@142182|Gemmatimonadetes 142182|Gemmatimonadetes V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_5914292_15 861299.J421_1983 1.539e-43 176.0 COG1538@1|root,COG1538@2|Bacteria,1ZT9S@142182|Gemmatimonadetes 142182|Gemmatimonadetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP GZD1_k127_5914292_16 1379270.AUXF01000002_gene1849 4.498e-36 144.0 COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_5914292_6 666685.R2APBS1_2192 1.888e-94 332.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1X513@135614|Xanthomonadales 135614|Xanthomonadales I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 GZD1_k127_5914292_7 861299.J421_2433 6.143e-72 261.0 COG2316@1|root,COG2316@2|Bacteria,1ZTH6@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD GZD1_k127_5914292_4 886293.Sinac_2659 1.399e-124 420.0 COG0367@1|root,COG0367@2|Bacteria,2J23D@203682|Planctomycetes 203682|Planctomycetes E TIGRFAM asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 GZD1_k127_5914292_13 243233.MCA0471 1.643e-55 214.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1XGYK@135618|Methylococcales 135618|Methylococcales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 GZD1_k127_5914292_19 1379270.AUXF01000004_gene3272 1.028e-15 89.0 2A0X4@1|root,30P27@2|Bacteria,1ZUWS@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_5914292_14 861299.J421_1517 2.556e-44 178.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_1517|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - GZD1_k127_5914292_11 386456.JQKN01000018_gene605 1.987e-59 215.0 COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,23P0H@183925|Methanobacteria 183925|Methanobacteria O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase GZD1_k127_5914292_9 1121405.dsmv_3719 1.972e-68 255.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2MI64@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red GZD1_k127_5914292_18 682795.AciX8_1320 6.234e-29 126.0 COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria,2JISJ@204432|Acidobacteriia 204432|Acidobacteriia O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH GZD1_k127_593329_1 330214.NIDE3598 9.055e-27 109.0 COG0702@1|root,COG0702@2|Bacteria 2|Bacteria GM epimerase - - - - - - - - - - - - NmrA GZD1_k127_593329_0 204669.Acid345_0476 3.243e-141 461.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,3Y2NX@57723|Acidobacteria 57723|Acidobacteria O L-lysine 6-monooxygenase (NADPH-requiring) - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_3 GZD1_k127_5939240_0 861299.J421_3453 3.449e-84 289.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE GZD1_k127_5939240_2 861299.J421_3452 1.741e-59 228.0 COG0030@1|root,COG0030@2|Bacteria,1ZT2M@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD GZD1_k127_5939240_1 861299.J421_3451 2.047e-67 235.0 COG2344@1|root,COG2344@2|Bacteria,1ZTJV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N GZD1_k127_5939240_3 889378.Spiaf_1193 7.138e-45 174.0 COG2235@1|root,COG2235@2|Bacteria,2J57H@203691|Spirochaetes 203691|Spirochaetes E Arginine - - 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 - R00552 RC00177 ko00000,ko00001,ko01000 - - - Amidinotransf GZD1_k127_5952683_11 379066.GAU_1754 2.194e-52 186.0 COG0124@1|root,COG0124@2|Bacteria,1ZSXX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_His GZD1_k127_5952683_8 379066.GAU_1755 1.271e-87 310.0 COG0285@1|root,COG0285@2|Bacteria,1ZSRP@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Mur ligase middle domain - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M GZD1_k127_5952683_7 379066.GAU_1756 8.584e-124 402.0 COG0777@1|root,COG0777@2|Bacteria,1ZSSK@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans GZD1_k127_5952683_5 379066.GAU_1757 6.741e-128 429.0 COG0772@1|root,COG0772@2|Bacteria,1ZSXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell cycle protein - - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE GZD1_k127_5952683_3 1379270.AUXF01000006_gene136 1.15e-170 563.0 COG0768@1|root,COG0768@2|Bacteria,1ZSX5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase GZD1_k127_5952683_14 861299.J421_3396 1.198e-29 129.0 2CIX2@1|root,33ZZP@2|Bacteria,1ZTZK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S rod shape-determining protein MreD - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD GZD1_k127_5952683_10 379066.GAU_1760 1.576e-57 210.0 COG1792@1|root,COG1792@2|Bacteria,1ZSYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M rod shape-determining protein MreC - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC GZD1_k127_5952683_1 1379270.AUXF01000006_gene133 2.229e-190 597.0 COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Hsp70 protein - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl GZD1_k127_5952683_4 861299.J421_0321 5.059e-152 499.0 COG2234@1|root,COG2234@2|Bacteria,1ZSXY@142182|Gemmatimonadetes 2|Bacteria S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 GZD1_k127_5952683_15 1121440.AUMA01000005_gene2633 3.503e-09 60.0 COG1148@1|root,COG1578@1|root,COG1148@2|Bacteria,COG1578@2|Bacteria,1RI11@1224|Proteobacteria,42RA1@68525|delta/epsilon subdivisions,2WMCD@28221|Deltaproteobacteria,2MBST@213115|Desulfovibrionales 28221|Deltaproteobacteria C Protein of unknown function DUF89 - - - ko:K09116 - - - - ko00000 - - - DUF89 GZD1_k127_5952683_9 589924.Ferp_0366 1.927e-82 291.0 COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi 183980|Archaeoglobi C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - 1.3.1.101,1.3.7.11 ko:K17830 ko00564,map00564 - R10325,R10326,R10331 RC03134 ko00000,ko00001,ko01000 - - - FAD_binding_3 GZD1_k127_5952683_13 1379698.RBG1_1C00001G1162 1.003e-30 133.0 COG0726@1|root,COG0726@2|Bacteria,2NPY1@2323|unclassified Bacteria 2|Bacteria G Polysaccharide deacetylase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Polysacc_deac_1 GZD1_k127_5952683_12 744979.R2A130_2051 6.677e-43 169.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria 28211|Alphaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase GZD1_k127_5952683_2 861299.J421_3399 3.065e-171 545.0 COG0686@1|root,COG0686@2|Bacteria,1ZSSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Alanine dehydrogenase/PNT, N-terminal domain - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N GZD1_k127_5952683_6 861299.J421_3400 2.599e-126 417.0 COG0612@1|root,COG0612@2|Bacteria,1ZSPT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C GZD1_k127_5952683_0 379066.GAU_1764 1.335e-291 910.0 COG1185@1|root,COG1185@2|Bacteria,1ZT7C@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 GZD1_k127_6031927_0 1379270.AUXF01000002_gene1577 1.262e-147 497.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase GZD1_k127_6031927_1 1120973.AQXL01000097_gene909 5.941e-115 379.0 COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4HEB4@91061|Bacilli,279KW@186823|Alicyclobacillaceae 91061|Bacilli S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran GZD1_k127_6031927_3 634956.Geoth_1647 2.294e-53 199.0 COG4587@1|root,COG4587@2|Bacteria,1V0NV@1239|Firmicutes,4IRGP@91061|Bacilli,1WHYB@129337|Geobacillus 91061|Bacilli S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 GZD1_k127_6031927_2 1122915.AUGY01000008_gene5085 3.586e-58 221.0 COG3694@1|root,COG3694@2|Bacteria,1UZ6K@1239|Firmicutes,4HCYU@91061|Bacilli,276WH@186822|Paenibacillaceae 91061|Bacilli S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 GZD1_k127_604593_1 670307.HYPDE_29643 1.038e-18 93.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,3N7HK@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C PQQ enzyme repeat - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 GZD1_k127_604593_0 1041142.ATTP01000010_gene1486 1.234e-85 296.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2TU3M@28211|Alphaproteobacteria,4BBEB@82115|Rhizobiaceae 28211|Alphaproteobacteria GM ATP-binding protein wzt - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C GZD1_k127_611065_4 1379270.AUXF01000004_gene2892 1.162e-144 486.0 COG4485@1|root,COG4485@2|Bacteria 2|Bacteria M Bacterial membrane protein, YfhO - - - - - - - - - - - - YfhO GZD1_k127_611065_14 379066.GAU_1614 4.211e-58 216.0 COG0392@1|root,COG0392@2|Bacteria,1ZTX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM GZD1_k127_611065_9 861299.J421_3248 2.556e-93 323.0 COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 GZD1_k127_611065_26 269797.Mbar_A1140 2.39e-18 98.0 COG0726@1|root,arCOG02877@2157|Archaea,2XT5E@28890|Euryarchaeota,2NABM@224756|Methanomicrobia 224756|Methanomicrobia G 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - - - - - - - - - - - GZD1_k127_611065_12 360910.BAV0089 4.651e-63 229.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity - - 2.3.1.157,2.3.1.79,2.7.7.23 ko:K00661,ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2 GZD1_k127_611065_22 981369.JQMJ01000001_gene6686 5.351e-30 132.0 COG2373@1|root,COG3391@1|root,COG2373@2|Bacteria,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,2NFQM@228398|Streptacidiphilus 201174|Actinobacteria M IPT/TIG domain - - - - - - - - - - - - Cytochrom_D1,Lactonase GZD1_k127_611065_20 192952.MM_2923 2.039e-31 143.0 COG3391@1|root,arCOG02527@1|root,arCOG02527@2157|Archaea,arCOG02562@2157|Archaea,2XVNE@28890|Euryarchaeota 28890|Euryarchaeota S 40-residue YVTN family beta-propeller - - - - - - - - - - - - Lactonase GZD1_k127_611065_27 78245.Xaut_0031 2.423e-16 92.0 COG3391@1|root,COG3391@2|Bacteria,1MXJJ@1224|Proteobacteria,2TTH6@28211|Alphaproteobacteria,3EY9I@335928|Xanthobacteraceae 28211|Alphaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - - - - - - - - - - Cytochrom_D1,Lactonase,NHL GZD1_k127_611065_8 861299.J421_3249 4.012e-95 333.0 COG0463@1|root,COG0463@2|Bacteria,1ZTEI@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 GZD1_k127_611065_3 861299.J421_3250 9.315e-199 631.0 COG1508@1|root,COG1508@2|Bacteria,1ZT13@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-54 factor, Activator interacting domain (AID) - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD GZD1_k127_611065_5 861299.J421_3251 7.623e-127 428.0 COG1137@1|root,COG1137@2|Bacteria,1ZT4S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran GZD1_k127_611065_19 379066.GAU_1619 3.293e-34 149.0 2F01D@1|root,33T57@2|Bacteria,1ZTGK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_611065_25 861299.J421_3253 1.156e-25 115.0 2DWX3@1|root,342B9@2|Bacteria,1ZTXN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lipopolysaccharide-assembly, LptC-related - - - - - - - - - - - - LptC GZD1_k127_611065_6 861299.J421_3254 2.999e-110 366.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1ZT08@142182|Gemmatimonadetes 142182|Gemmatimonadetes M SIS domain - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS GZD1_k127_611065_17 861299.J421_3255 7.894e-47 177.0 COG1778@1|root,COG1778@2|Bacteria,1ZTTG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S haloacid dehalogenase-like hydrolase - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 GZD1_k127_611065_7 1379270.AUXF01000006_gene266 1.096e-107 356.0 COG2877@1|root,COG2877@2|Bacteria,1ZUCD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M DAHP synthetase I family - - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 GZD1_k127_611065_2 1379270.AUXF01000006_gene265 1.584e-264 824.0 COG0504@1|root,COG0504@2|Bacteria,1ZT0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase GZD1_k127_611065_13 379066.GAU_1625 1.418e-58 212.0 COG1212@1|root,COG1212@2|Bacteria,1ZSRD@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 GZD1_k127_611065_11 1382356.JQMP01000004_gene441 5.392e-72 250.0 COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi,27Y8S@189775|Thermomicrobia 189775|Thermomicrobia EH Peptidase C26 - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase GZD1_k127_611065_31 1131814.JAFO01000001_gene976 0.0005363 51.0 2EG5G@1|root,339XD@2|Bacteria,1NIP5@1224|Proteobacteria,2UMDK@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - GZD1_k127_611065_16 1379698.RBG1_1C00001G0328 3.379e-47 182.0 2C7E0@1|root,330TX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_611065_23 192952.MM_3257 2.073e-27 116.0 COG4741@1|root,arCOG05252@2157|Archaea,2XYG2@28890|Euryarchaeota,2NAZM@224756|Methanomicrobia 224756|Methanomicrobia F Endonuclease related to archaeal Holliday junction resolvase - - - - - - - - - - - - Endonuc_Holl GZD1_k127_611065_1 234267.Acid_0469 1.275e-304 953.0 COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria 57723|Acidobacteria E peptidase S9B dipeptidylpeptidase IV domain protein - - - - - - - - - - - - DPPIV_N,Peptidase_S9 GZD1_k127_611065_15 1382358.JHVN01000001_gene804 4.354e-53 193.0 COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,4HHKH@91061|Bacilli 91061|Bacilli S Uncharacterised protein family UPF0066 - - - - - - - - - - - - UPF0066 GZD1_k127_611065_21 366602.Caul_2927 3.408e-31 132.0 COG3797@1|root,COG3797@2|Bacteria,1N0SN@1224|Proteobacteria,2UI5V@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 GZD1_k127_611065_18 1137799.GZ78_02215 2.178e-44 169.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1XJBF@135619|Oceanospirillales 135619|Oceanospirillales U UPF0056 membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC GZD1_k127_611065_24 1267533.KB906736_gene974 1.146e-25 109.0 COG3324@1|root,COG3324@2|Bacteria,3Y5FK@57723|Acidobacteria,2JJUB@204432|Acidobacteriia 204432|Acidobacteriia S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase GZD1_k127_611065_29 1380393.JHVP01000004_gene348 7.713e-08 60.0 COG0346@1|root,COG0346@2|Bacteria,2GS59@201174|Actinobacteria,4EWSW@85013|Frankiales 201174|Actinobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase GZD1_k127_611065_10 580332.Slit_1871 2.714e-81 282.0 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2VJ27@28216|Betaproteobacteria 28216|Betaproteobacteria S membrane - - - - - - - - - - - - VIT1 GZD1_k127_611065_0 861299.J421_3342 0.0 1064.0 COG0826@1|root,COG0826@2|Bacteria,1ZTET@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Collagenase - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 GZD1_k127_611065_28 867903.ThesuDRAFT_00625 2.142e-14 74.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,3WCJ8@538999|Clostridiales incertae sedis 186801|Clostridia F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like GZD1_k127_756566_6 379066.GAU_1936 1.096e-81 273.0 COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N GZD1_k127_756566_2 861299.J421_3546 2.008e-162 525.0 COG2986@1|root,COG2986@2|Bacteria,1ZTEG@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic GZD1_k127_756566_3 861299.J421_3547 3.312e-131 462.0 COG1452@1|root,COG1452@2|Bacteria,1ZT14@142182|Gemmatimonadetes 142182|Gemmatimonadetes M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - GZD1_k127_756566_9 861299.J421_3548 1.668e-45 191.0 COG0805@1|root,COG0805@2|Bacteria,1ZTHN@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC GZD1_k127_756566_17 1122132.AQYH01000002_gene1259 1.774e-12 77.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2U6ZQ@28211|Alphaproteobacteria,4B7PV@82115|Rhizobiaceae 28211|Alphaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri GZD1_k127_756566_11 1379270.AUXF01000006_gene18 4.554e-37 151.0 COG2885@1|root,COG2885@2|Bacteria,1ZTSM@142182|Gemmatimonadetes 142182|Gemmatimonadetes M OmpA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA GZD1_k127_756566_5 379066.GAU_1942 6.78e-90 315.0 COG0823@1|root,COG0823@2|Bacteria,1ZTBK@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 GZD1_k127_756566_14 1379270.AUXF01000006_gene16 6.227e-21 108.0 COG0810@1|root,COG0810@2|Bacteria,1ZTWX@142182|Gemmatimonadetes 142182|Gemmatimonadetes M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2 GZD1_k127_756566_10 379066.GAU_1944 6.939e-39 149.0 COG0848@1|root,COG0848@2|Bacteria,1ZTRS@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD GZD1_k127_756566_7 861299.J421_3554 2.687e-59 213.0 COG0811@1|root,COG0811@2|Bacteria,1ZTBF@142182|Gemmatimonadetes 142182|Gemmatimonadetes U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB GZD1_k127_756566_4 1379270.AUXF01000006_gene13 7.641e-103 346.0 COG1087@1|root,COG1087@2|Bacteria,1ZSX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd GZD1_k127_756566_18 589865.DaAHT2_0183 2.102e-11 76.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42QS9@68525|delta/epsilon subdivisions,2WN3H@28221|Deltaproteobacteria,2MJ1W@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidoglycan-binding LysM - - - - - - - - - - - - LysM GZD1_k127_756566_8 1379270.AUXF01000006_gene11 3.777e-54 195.0 COG0629@1|root,COG0629@2|Bacteria,1ZTPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB GZD1_k127_756566_13 861299.J421_3558 6.958e-29 127.0 COG0454@1|root,COG0456@2|Bacteria,1ZU09@142182|Gemmatimonadetes 142182|Gemmatimonadetes K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 GZD1_k127_756566_15 1123288.SOV_1c03410 1.087e-16 89.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4H47Z@909932|Negativicutes 909932|Negativicutes O Universal bacterial protein YeaZ yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 GZD1_k127_756566_12 861299.J421_3560 6.443e-30 123.0 COG0802@1|root,COG0802@2|Bacteria,1ZTY0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - 2.7.1.221 ko:K06925,ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko03016 - - - TsaE GZD1_k127_756566_0 861299.J421_3561 2.968e-307 955.0 COG0556@1|root,COG0556@2|Bacteria,1ZSQS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB GZD1_k127_756566_1 861299.J421_3563 2.344e-260 816.0 COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS GZD1_k127_763034_1 530564.Psta_2478 9.238e-24 101.0 COG0388@1|root,COG0388@2|Bacteria,2IX91@203682|Planctomycetes 203682|Planctomycetes S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase GZD1_k127_763034_0 357808.RoseRS_2742 4.645e-144 465.0 COG2957@1|root,COG2957@2|Bacteria,2GAHD@200795|Chloroflexi,37657@32061|Chloroflexia 32061|Chloroflexia E Belongs to the agmatine deiminase family - - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph GZD1_k127_775304_0 861299.J421_3441 3.486e-200 635.0 COG1418@1|root,COG1418@2|Bacteria,1ZT0I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 GZD1_k127_775304_2 861299.J421_3442 3.013e-19 91.0 COG3027@1|root,COG3027@2|Bacteria,1ZU4G@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA GZD1_k127_775304_1 1125863.JAFN01000001_gene1869 2.225e-129 439.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind GZD1_k127_776334_0 251221.35211765 1.389e-95 331.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD GZD1_k127_776334_1 861299.J421_0601 1.64e-32 130.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD GZD1_k127_810991_4 1121930.AQXG01000001_gene1166 2.841e-06 50.0 COG1404@1|root,COG1404@2|Bacteria,4NVH2@976|Bacteroidetes 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - - GZD1_k127_810991_1 1538295.JY96_10800 3.483e-24 118.0 COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2VVTK@28216|Betaproteobacteria,1KMJG@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF937) - - - - - - - - - - - - DUF937 GZD1_k127_810991_0 269799.Gmet_2745 2.503e-36 150.0 COG1555@1|root,COG1555@2|Bacteria,1PZ0T@1224|Proteobacteria,437E3@68525|delta/epsilon subdivisions,2XA24@28221|Deltaproteobacteria,43VVP@69541|Desulfuromonadales 28221|Deltaproteobacteria L Helix-hairpin-helix motif - - - - - - - - - - - - HHH_3 GZD1_k127_810991_2 1306990.BARG01000024_gene2386 5.321e-12 76.0 2C84R@1|root,2ZY1B@2|Bacteria,2GW45@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - GZD1_k127_810991_3 471853.Bcav_2176 8.391e-07 57.0 COG3568@1|root,COG3568@2|Bacteria,2H3ST@201174|Actinobacteria 201174|Actinobacteria G endonuclease exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos GZD1_k127_887635_40 518766.Rmar_1620 3.18e-25 109.0 COG1762@1|root,COG1762@2|Bacteria,4NY7D@976|Bacteroidetes,1FJF6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - 2.7.1.202 ko:K02768 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2 GZD1_k127_887635_3 861299.J421_3356 2.255e-207 660.0 COG0173@1|root,COG0173@2|Bacteria,1ZTFX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon GZD1_k127_887635_11 379066.GAU_1714 7.083e-127 416.0 COG1702@1|root,COG1702@2|Bacteria,1ZSSD@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH GZD1_k127_887635_12 861299.J421_3354 5.067e-124 415.0 COG1480@1|root,COG1480@2|Bacteria 2|Bacteria O 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD GZD1_k127_887635_41 1380356.JNIK01000001_gene2242 4.085e-11 70.0 COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4ESS6@85013|Frankiales 201174|Actinobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 GZD1_k127_887635_23 861299.J421_3352 6.634e-69 250.0 COG1253@1|root,COG1253@2|Bacteria,1ZT3E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC GZD1_k127_887635_37 1463821.JOGR01000006_gene2613 9.783e-33 144.0 COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4EXRE@85014|Glycomycetales 201174|Actinobacteria S Transporter associated domain corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 GZD1_k127_887635_16 861299.J421_3350 7.044e-113 374.0 COG1703@1|root,COG1703@2|Bacteria,1ZT8J@142182|Gemmatimonadetes 142182|Gemmatimonadetes E ArgK protein - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK GZD1_k127_887635_1 861299.J421_3349 2.299e-264 822.0 COG1884@1|root,COG1884@2|Bacteria,1ZUKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.13,5.4.99.2 ko:K01848,ko:K11942 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase GZD1_k127_887635_24 861299.J421_3347 2.049e-63 221.0 COG2185@1|root,COG2185@2|Bacteria,1ZTNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding GZD1_k127_887635_2 861299.J421_3346 2.609e-233 731.0 COG4799@1|root,COG4799@2|Bacteria,1ZTGB@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans GZD1_k127_887635_22 945713.IALB_3165 4.623e-81 308.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - 3.4.14.10 ko:K01280 - - - - ko00000,ko01000,ko01002,ko03110 - - - PPC,Peptidase_S8 GZD1_k127_887635_4 1379270.AUXF01000006_gene185 2.018e-198 639.0 COG3185@1|root,COG3185@2|Bacteria,1ZT5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA GZD1_k127_887635_32 861299.J421_3344 5.18e-41 156.0 2CIU6@1|root,32S8H@2|Bacteria,1ZTUM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_887635_29 880073.Calab_3476 1.563e-49 187.0 COG1024@1|root,COG1024@2|Bacteria,2NR3A@2323|unclassified Bacteria 2|Bacteria I Enoyl-CoA hydratase/isomerase liuC - 4.2.1.17,4.2.1.18,4.2.1.57 ko:K01692,ko:K13766,ko:K13779 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00036,M00087 R02085,R03026,R03045,R03493,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC00941,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 GZD1_k127_887635_42 1304275.C41B8_01085 0.0002451 52.0 COG4969@1|root,COG4969@2|Bacteria,1N2PY@1224|Proteobacteria,1SASE@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Pilin (bacterial filament) - - - - - - - - - - - - N_methyl,Pilin GZD1_k127_887635_9 309801.trd_A0811 8.384e-156 507.0 COG1032@1|root,COG1032@2|Bacteria,2G7MA@200795|Chloroflexi,27Y05@189775|Thermomicrobia 189775|Thermomicrobia C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM GZD1_k127_887635_28 861299.J421_3020 7.864e-52 190.0 2DYQC@1|root,34AP6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - GZD1_k127_887635_7 861299.J421_3019 8.929e-172 552.0 COG2268@1|root,COG2268@2|Bacteria 2|Bacteria T Band 7 protein - - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot GZD1_k127_887635_30 1121346.KB899820_gene2763 2.574e-48 178.0 28NYH@1|root,2ZBVN@2|Bacteria,1V1T3@1239|Firmicutes,4HHZS@91061|Bacilli,26WPV@186822|Paenibacillaceae 91061|Bacilli S Belongs to the UPF0403 family yphP - - - - - - - - - - - Disulph_isomer GZD1_k127_887635_33 861299.J421_2069 1.09e-38 154.0 COG0234@1|root,COG0234@2|Bacteria,1ZU6V@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - - - - - - - - - - Cpn10 GZD1_k127_887635_19 1224136.AMFN01000023_gene1888 1.592e-94 326.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,28369@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria L RQC recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind GZD1_k127_887635_18 1128421.JAGA01000002_gene1080 3.838e-96 327.0 COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria 2|Bacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,GSDH GZD1_k127_887635_5 379066.GAU_1701 8.683e-181 573.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N GZD1_k127_887635_26 1499967.BAYZ01000171_gene5616 1.916e-55 203.0 COG4420@1|root,COG4420@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1003) yejC - - - - - - - - - - - DUF1003 GZD1_k127_887635_0 211165.AJLN01000074_gene6344 4.535e-275 864.0 COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1JMTM@1189|Stigonemataceae 1117|Cyanobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N GZD1_k127_887635_14 1191523.MROS_1725 4.391e-116 392.0 COG1530@1|root,COG1530@2|Bacteria 2|Bacteria J ribonuclease E activity rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 GZD1_k127_887635_39 379066.GAU_1699 1.374e-29 120.0 COG0261@1|root,COG0261@2|Bacteria,1ZTS8@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p GZD1_k127_887635_35 1487953.JMKF01000009_gene6172 3.212e-37 141.0 COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1HCCX@1150|Oscillatoriales 1117|Cyanobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 GZD1_k127_887635_13 861299.J421_3334 1.932e-119 396.0 COG1228@1|root,COG1228@2|Bacteria,1ZTI7@142182|Gemmatimonadetes 861299.J421_3334|- Q Amidohydrolase family - - - - - - - - - - - - - GZD1_k127_887635_6 861299.J421_3333 1.501e-174 567.0 COG1228@1|root,COG1228@2|Bacteria,1ZTC8@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 GZD1_k127_887635_25 1519464.HY22_01680 1.026e-61 239.0 COG0612@1|root,COG0612@2|Bacteria,1FENV@1090|Chlorobi 1090|Chlorobi S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C GZD1_k127_887635_21 379066.GAU_3919 2.995e-81 291.0 COG0612@1|root,COG0612@2|Bacteria,1ZSVK@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C GZD1_k127_887635_17 861299.J421_5582 2.559e-112 373.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase bamU - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 GZD1_k127_887635_20 502025.Hoch_3320 2.774e-93 325.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42PBC@68525|delta/epsilon subdivisions,2WM7S@28221|Deltaproteobacteria,2YY2B@29|Myxococcales 28221|Deltaproteobacteria C 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N GZD1_k127_887635_31 1379270.AUXF01000006_gene195 7.914e-46 177.0 COG0584@1|root,COG0584@2|Bacteria,1ZTTY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD GZD1_k127_887635_27 365046.Rta_22300 4.372e-55 212.0 COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,4ACAF@80864|Comamonadaceae 28216|Betaproteobacteria S benzoyl-CoA oxygenase boxB - 1.14.13.208 ko:K15512 ko00362,map00362 - R09555 RC01739 ko00000,ko00001,ko01000 - - - - GZD1_k127_887635_34 929703.KE386491_gene611 1.829e-38 162.0 COG1024@1|root,COG1024@2|Bacteria,4NHRF@976|Bacteroidetes,47JJ9@768503|Cytophagia 976|Bacteroidetes I enoyl-CoA hydratase isomerase family - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 GZD1_k127_887635_10 292459.STH720 1.804e-151 492.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia 186801|Clostridia I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N GZD1_k127_887635_8 1121090.KB894685_gene3488 1.639e-167 539.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1ZAY9@1386|Bacillus 91061|Bacilli C Belongs to the aldehyde dehydrogenase family dhaS - 1.2.1.3,1.2.1.39 ko:K00128,ko:K00146 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh GZD1_k127_887635_15 1379698.RBG1_1C00001G0806 2.996e-114 375.0 COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria 2|Bacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 GZD1_k127_887635_38 1125863.JAFN01000001_gene2929 2.467e-31 130.0 COG1309@1|root,COG1309@2|Bacteria,1N9ZB@1224|Proteobacteria,42VC2@68525|delta/epsilon subdivisions,2WRA9@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N GZD1_k127_887635_36 379066.GAU_1695 9.111e-35 143.0 COG1595@1|root,COG1595@2|Bacteria,1ZTKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_896423_2 266117.Rxyl_0337 6.977e-54 213.0 2AI77@1|root,318MJ@2|Bacteria,2IG4V@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - GZD1_k127_896423_0 266117.Rxyl_0336 8.234e-232 727.0 COG3391@1|root,COG3391@2|Bacteria,2I9U0@201174|Actinobacteria,4CSKA@84995|Rubrobacteria 84995|Rubrobacteria S 56kDa selenium binding protein (SBP56) - - - ko:K17285 - - - - ko00000,ko04147 - - - SBP56 GZD1_k127_896423_1 452637.Oter_3544 1.623e-88 297.0 COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B,Cytochrome_CBB3 GZD1_k127_932789_5 1121904.ARBP01000028_gene1652 2.025e-09 60.0 COG2194@1|root,COG2194@2|Bacteria 2|Bacteria T sulfuric ester hydrolase activity kbaA GO:0008150,GO:0022603,GO:0042173,GO:0043937,GO:0043938,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 2.7.8.43 ko:K03760,ko:K06349,ko:K19353 ko00540,ko01503,map00540,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,KbaA,Sulfatase GZD1_k127_932789_3 1121904.ARBP01000028_gene1653 3.162e-17 86.0 COG3311@1|root,COG3311@2|Bacteria 2|Bacteria K DNA excision - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - HTH_17,PTS_EIIA_2 GZD1_k127_932789_1 1382359.JIAL01000001_gene2460 3.037e-166 538.0 COG1680@1|root,COG1680@2|Bacteria,3Y3DY@57723|Acidobacteria,2JHVC@204432|Acidobacteriia 204432|Acidobacteriia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase GZD1_k127_932789_0 861299.J421_2179 2.905e-172 563.0 COG0308@1|root,COG0308@2|Bacteria,1ZUT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 GZD1_k127_932789_2 357808.RoseRS_2424 2.607e-67 233.0 COG0229@1|root,COG0229@2|Bacteria,2G78V@200795|Chloroflexi 200795|Chloroflexi C PFAM Methionine sulfoxide reductase B msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR GZD1_k127_944661_13 1443125.Z962_03785 1.687e-07 59.0 COG0622@1|root,COG0622@2|Bacteria,1VADJ@1239|Firmicutes,25CNG@186801|Clostridia,36WYB@31979|Clostridiaceae 186801|Clostridia S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 GZD1_k127_944661_6 1379270.AUXF01000003_gene3488 2.4e-76 260.0 COG0163@1|root,COG0163@2|Bacteria,1ZTIK@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein GZD1_k127_944661_4 861299.J421_3905 2.779e-91 309.0 COG0382@1|root,COG0382@2|Bacteria,1ZT35@142182|Gemmatimonadetes 142182|Gemmatimonadetes H UbiA prenyltransferase family - - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA GZD1_k127_944661_0 861299.J421_3906 1.26e-239 748.0 COG0043@1|root,COG0043@2|Bacteria,1ZSMS@142182|Gemmatimonadetes 142182|Gemmatimonadetes H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD GZD1_k127_944661_9 649638.Trad_1207 6.563e-48 182.0 COG0500@1|root,COG2226@2|Bacteria,1WIUM@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran GZD1_k127_944661_5 379066.GAU_2442 2.687e-80 272.0 COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 GZD1_k127_944661_14 861299.J421_3909 4.945e-06 53.0 2F9A9@1|root,341MC@2|Bacteria,1ZU0R@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_944661_8 861299.J421_3913 8.872e-64 243.0 COG1912@1|root,COG1912@2|Bacteria,1ZTIH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans GZD1_k127_944661_3 1379270.AUXF01000003_gene3480 3.249e-108 376.0 COG0534@1|root,COG0534@2|Bacteria,1ZTFM@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE GZD1_k127_944661_2 861299.J421_3915 5.924e-118 389.0 COG0489@1|root,COG0489@2|Bacteria,1ZSW7@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA GZD1_k127_944661_7 379066.GAU_0129 2.344e-64 238.0 COG0612@1|root,COG0612@2|Bacteria,1ZT1J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C GZD1_k127_944661_12 572477.Alvin_2887 1.693e-13 84.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1WXE8@135613|Chromatiales 135613|Chromatiales S PFAM Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C GZD1_k127_944661_1 204669.Acid345_1677 1.882e-133 456.0 COG3345@1|root,COG3345@2|Bacteria,3Y98F@57723|Acidobacteria,2JP4Z@204432|Acidobacteriia 204432|Acidobacteriia G Melibiase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase_2,Melibiase_2_C GZD1_k127_944661_11 497965.Cyan7822_0792 3.698e-17 91.0 COG1100@1|root,COG4886@1|root,COG1100@2|Bacteria,COG4886@2|Bacteria,1G05B@1117|Cyanobacteria,3KFSF@43988|Cyanothece 1117|Cyanobacteria S leucine-rich repeat-containing protein typical subtype - - - ko:K06883 - - - - ko00000 - - - COR,LRR_8,Roc GZD1_k127_944661_10 215803.DB30_0881 3.047e-18 87.0 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales 28221|Deltaproteobacteria O Fibronectin type 3 domain - - - - - - - - - - - - Peptidase_M6,Peptidase_S8 GZD1_k127_996934_3 379066.GAU_0734 2.423e-163 530.0 COG0143@1|root,COG0143@2|Bacteria,1ZTDB@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (M) - - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g GZD1_k127_996934_14 1242864.D187_008877 1.741e-42 168.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 GZD1_k127_996934_11 379066.GAU_0729 2.529e-57 206.0 COG1704@1|root,COG1704@2|Bacteria,1ZTQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA GZD1_k127_996934_17 382464.ABSI01000011_gene2923 4.996e-24 117.0 COG1708@1|root,COG1708@2|Bacteria 2|Bacteria S nucleotidyltransferase activity ant1 - 2.7.7.47 ko:K00984,ko:K19279 - - - - ko00000,ko01000,ko01504 - - - DUF4111,NTP_transf_2,UPF0158 GZD1_k127_996934_13 861299.J421_2643 9.139e-43 166.0 COG1512@1|root,COG1512@2|Bacteria,1ZT1H@142182|Gemmatimonadetes 142182|Gemmatimonadetes S TPM domain - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase GZD1_k127_996934_19 1379270.AUXF01000007_gene936 3.648e-08 61.0 COG1629@1|root,COG4771@2|Bacteria,1ZUKQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - Plug,TonB_dep_Rec GZD1_k127_996934_8 861299.J421_1823 6.771e-74 276.0 28P8D@1|root,2ZC2C@2|Bacteria,1ZUEX@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - GZD1_k127_996934_2 861299.J421_1822 1.941e-223 730.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec GZD1_k127_996934_16 326427.Cagg_0503 1.076e-35 145.0 COG1651@1|root,COG1651@2|Bacteria,2G8TG@200795|Chloroflexi,375RW@32061|Chloroflexia 32061|Chloroflexia O PFAM DSBA oxidoreductase - - - - - - - - - - - - Thioredoxin_4 GZD1_k127_996934_5 861299.J421_2641 3.701e-111 377.0 COG1519@1|root,COG1519@2|Bacteria,1ZSXB@142182|Gemmatimonadetes 142182|Gemmatimonadetes M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N GZD1_k127_996934_18 379066.GAU_0717 1.167e-19 92.0 COG0355@1|root,COG0355@2|Bacteria,1ZU1K@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N GZD1_k127_996934_1 861299.J421_2629 3.471e-247 771.0 COG0055@1|root,COG0055@2|Bacteria,1ZSNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N GZD1_k127_996934_6 861299.J421_2628 1.191e-106 375.0 COG0224@1|root,COG0224@2|Bacteria,1ZSZR@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt GZD1_k127_996934_0 861299.J421_2627 1.148e-257 801.0 COG0056@1|root,COG0056@2|Bacteria,1ZSNY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N GZD1_k127_996934_15 1379270.AUXF01000004_gene3175 1.732e-37 152.0 COG2207@1|root,COG2207@2|Bacteria,1ZUCN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 GZD1_k127_996934_12 861299.J421_2626 5.707e-49 179.0 COG1051@1|root,COG1051@2|Bacteria,1ZTP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX GZD1_k127_996934_9 1379270.AUXF01000007_gene1059 3.722e-71 256.0 COG1463@1|root,COG1463@2|Bacteria,1ZUJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD GZD1_k127_996934_10 626939.HMPREF9443_00584 4.671e-69 253.0 COG1127@1|root,COG1127@2|Bacteria,1UGV0@1239|Firmicutes,4H251@909932|Negativicutes 909932|Negativicutes Q ABC transporter, ATP-binding protein ttg2A - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran GZD1_k127_996934_7 1379270.AUXF01000007_gene1058 2.249e-82 280.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE GZD1_k127_996934_4 861299.J421_2624 3.751e-143 463.0 COG0568@1|root,COG0568@2|Bacteria,1ZTCX@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 ## 2614 queries scanned ## Total time (seconds): 134.05012392997742 ## Rate: 19.50 q/s