## Mon Nov 11 21:12:09 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/H/HFD1_bin.24.fa -m mmseqs --itype genome -o HFD1_bin.24 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/HFD1_bin.24 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HFD1_k127_1010824_3	196490.AUEZ01000031_gene2801	1.9e-61	222.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,3JUS1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
HFD1_k127_1010824_6	1121861.KB899951_gene2301	4.493e-24	104.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,2JQR2@204441|Rhodospirillales	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
HFD1_k127_1010824_2	420324.KI912044_gene3907	2.673e-79	271.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,1JZD4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	KT	helix_turn_helix, Lux Regulon	mctR	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD1_k127_1010824_1	420324.KI912044_gene3909	2.371e-114	382.0	COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,2TVYD@28211|Alphaproteobacteria,1JZHG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase	degS	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,sCache_2
HFD1_k127_1010824_5	1123366.TH3_03429	2.059e-54	195.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,2JTP4@204441|Rhodospirillales	204441|Rhodospirillales	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HFD1_k127_1010824_9	1532558.JL39_23350	1.018e-05	53.0	COG1547@1|root,COG1547@2|Bacteria,1Q72Z@1224|Proteobacteria,2VD73@28211|Alphaproteobacteria,4BFH6@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
HFD1_k127_1010824_4	1316936.K678_13820	1.461e-54	199.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,2UBIJ@28211|Alphaproteobacteria,2JSX4@204441|Rhodospirillales	204441|Rhodospirillales	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
HFD1_k127_1010824_7	1242864.D187_006689	1.735e-11	71.0	COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria	1224|Proteobacteria	S	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
HFD1_k127_1010824_0	414684.RC1_0592	3.079e-214	687.0	COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2TQP6@28211|Alphaproteobacteria,2JP9G@204441|Rhodospirillales	204441|Rhodospirillales	S	Deoxyribodipyrimidine photo-lyase-related protein	-	-	-	ko:K06876	-	-	-	-	ko00000	-	-	-	DPRP
HFD1_k127_1010824_8	670307.HYPDE_35268	6.228e-08	54.0	COG0702@1|root,COG0702@2|Bacteria,1RDKF@1224|Proteobacteria,2U7MU@28211|Alphaproteobacteria,3N98D@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HFD1_k127_1028983_0	1123267.JONN01000001_gene1672	2.035e-203	638.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2K1J3@204457|Sphingomonadales	204457|Sphingomonadales	C	E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HFD1_k127_1028983_1	392499.Swit_1297	2.001e-89	302.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,2K18R@204457|Sphingomonadales	204457|Sphingomonadales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_1031884_1	1123267.JONN01000001_gene431	1.538e-187	600.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,Response_reg
HFD1_k127_1031884_0	1502850.FG91_01928	1.228e-227	709.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,2K0V8@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0156 7-keto-8-aminopelargonate synthetase and related enzymes	-	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_1031884_7	685778.AORL01000010_gene2832	7.512e-33	131.0	COG0236@1|root,COG0236@2|Bacteria,1NHQD@1224|Proteobacteria,2UGSG@28211|Alphaproteobacteria,2K5YB@204457|Sphingomonadales	204457|Sphingomonadales	IQ	acyl carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HFD1_k127_1031884_6	909663.KI867150_gene69	1.482e-60	217.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1031884_5	13689.BV96_03442	8.037e-72	249.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2U3PI@28211|Alphaproteobacteria,2K2PI@204457|Sphingomonadales	204457|Sphingomonadales	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD1_k127_1031884_3	1419583.V466_08800	2.285e-105	366.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	asparagine synthase, glutamine-hydrolyzing	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD1_k127_1031884_4	1123267.JONN01000001_gene1473	9.218e-105	351.0	COG0702@1|root,COG0702@2|Bacteria,1RCCP@1224|Proteobacteria,2TU1D@28211|Alphaproteobacteria,2K0TF@204457|Sphingomonadales	204457|Sphingomonadales	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HFD1_k127_1031884_2	194867.ALBQ01000011_gene371	1.521e-160	511.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,2K1GJ@204457|Sphingomonadales	204457|Sphingomonadales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HFD1_k127_1052503_2	1123267.JONN01000001_gene1606	2.928e-73	252.0	COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2TTDD@28211|Alphaproteobacteria,2K3XP@204457|Sphingomonadales	204457|Sphingomonadales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA_1	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD1_k127_1052503_0	1123267.JONN01000002_gene150	1.571e-257	806.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,2K0C0@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
HFD1_k127_1052503_1	745310.G432_17355	2.116e-93	315.0	COG0300@1|root,COG0300@2|Bacteria,1QUNR@1224|Proteobacteria,2TW24@28211|Alphaproteobacteria,2K1AC@204457|Sphingomonadales	204457|Sphingomonadales	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_1063341_23	1219035.NT2_07_00590	7.092e-71	253.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HFD1_k127_1063341_2	1123267.JONN01000001_gene463	4.43e-317	977.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,2K0KT@204457|Sphingomonadales	204457|Sphingomonadales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HFD1_k127_1063341_28	1123267.JONN01000001_gene464	1.308e-39	155.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,2K633@204457|Sphingomonadales	204457|Sphingomonadales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfB	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD1_k127_1063341_8	745310.G432_00860	1.605e-149	491.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2KCM1@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HFD1_k127_1063341_6	1030157.AFMP01000019_gene709	4.386e-166	535.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2TW1S@28211|Alphaproteobacteria,2K09D@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_1063341_20	1123267.JONN01000001_gene1634	3.163e-86	288.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,2K47C@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HFD1_k127_1063341_1	1096930.L284_18205	0.0	1159.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,2K0B7@204457|Sphingomonadales	204457|Sphingomonadales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HFD1_k127_1063341_9	745310.G432_01575	3.568e-140	454.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,2K012@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HFD1_k127_1063341_19	1470591.BW41_00610	5.694e-89	301.0	COG0730@1|root,COG0730@2|Bacteria,1RCVI@1224|Proteobacteria,2U5XM@28211|Alphaproteobacteria,2K04W@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD1_k127_1063341_16	1123267.JONN01000001_gene1469	3.101e-109	357.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TQQ5@28211|Alphaproteobacteria,2K2GH@204457|Sphingomonadales	204457|Sphingomonadales	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
HFD1_k127_1063341_30	316056.RPC_0202	8.463e-26	111.0	2CCMQ@1|root,32RW3@2|Bacteria,1MZHB@1224|Proteobacteria,2UCC9@28211|Alphaproteobacteria,3JYQ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2794)	MA20_43795	-	-	-	-	-	-	-	-	-	-	-	DUF2794
HFD1_k127_1063341_11	1123267.JONN01000001_gene1467	1.148e-137	447.0	2BXMY@1|root,2Z8Y9@2|Bacteria,1Q2YR@1224|Proteobacteria,2U06T@28211|Alphaproteobacteria,2K32G@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1063341_26	1123267.JONN01000001_gene1463	3.53e-56	201.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,2K3X3@204457|Sphingomonadales	204457|Sphingomonadales	L	Methyltransferase	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HFD1_k127_1063341_17	1123269.NX02_14215	5.002e-108	356.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,2K0YS@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD1_k127_1063341_29	13689.BV96_01857	1.836e-35	142.0	COG0745@1|root,COG0745@2|Bacteria,1N2D5@1224|Proteobacteria,2UUU2@28211|Alphaproteobacteria,2K55K@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_1063341_3	1112212.JH584235_gene3703	1.283e-221	701.0	COG4114@1|root,COG4114@2|Bacteria,1QZYT@1224|Proteobacteria,2TYSW@28211|Alphaproteobacteria,2KEN7@204457|Sphingomonadales	204457|Sphingomonadales	S	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn
HFD1_k127_1063341_7	1123267.JONN01000001_gene561	4.429e-153	499.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,2K1S3@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
HFD1_k127_1063341_10	1123267.JONN01000001_gene562	5.156e-139	447.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,2K159@204457|Sphingomonadales	204457|Sphingomonadales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD1_k127_1063341_22	1123267.JONN01000001_gene563	2.437e-82	279.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,2K06D@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HFD1_k127_1063341_31	1123267.JONN01000001_gene564	2.894e-24	109.0	COG5416@1|root,COG5416@2|Bacteria,1NFVX@1224|Proteobacteria,2UHIC@28211|Alphaproteobacteria,2K759@204457|Sphingomonadales	204457|Sphingomonadales	S	Pfam:DUF1049	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
HFD1_k127_1063341_4	1123267.JONN01000001_gene565	2.165e-175	559.0	COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,2U2AI@28211|Alphaproteobacteria,2K0Z4@204457|Sphingomonadales	204457|Sphingomonadales	V	beta-lactamase	-	-	3.5.2.6	ko:K01467	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase
HFD1_k127_1063341_25	366602.Caul_4302	2.152e-64	224.0	COG5592@1|root,COG5592@2|Bacteria,1RI8J@1224|Proteobacteria,2U7JS@28211|Alphaproteobacteria,2KH99@204458|Caulobacterales	204458|Caulobacterales	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD1_k127_1063341_15	1219035.NT2_07_00590	1.461e-116	389.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HFD1_k127_1063341_27	1123267.JONN01000001_gene1740	2.494e-46	176.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,2K2JH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,YkuD
HFD1_k127_1063341_5	1144275.COCOR_05913	8.872e-171	554.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,42YQ0@68525|delta/epsilon subdivisions,2WTRV@28221|Deltaproteobacteria,2YUFX@29|Myxococcales	28221|Deltaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1063341_34	240015.ACP_0672	3.191e-13	76.0	COG2010@1|root,COG2010@2|Bacteria,3Y4X7@57723|Acidobacteria,2JJFH@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_1063341_36	685778.AORL01000009_gene3352	1.642e-08	64.0	2AKT1@1|root,31BK2@2|Bacteria,1NXBB@1224|Proteobacteria,2UTRK@28211|Alphaproteobacteria,2K5KP@204457|Sphingomonadales	204457|Sphingomonadales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HFD1_k127_1063341_0	1123267.JONN01000001_gene570	0.0	1227.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,2K04E@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HFD1_k127_1063341_32	1030157.AFMP01000013_gene3328	1.772e-16	84.0	COG3794@1|root,COG3794@2|Bacteria,1N2CZ@1224|Proteobacteria,2UEDD@28211|Alphaproteobacteria,2K66I@204457|Sphingomonadales	204457|Sphingomonadales	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HFD1_k127_1063341_33	685778.AORL01000016_gene2332	1.112e-15	85.0	2ATYG@1|root,31JI4@2|Bacteria,1N46N@1224|Proteobacteria,2UCQE@28211|Alphaproteobacteria,2K7TH@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1063341_13	1090319.KE386571_gene2953	9.406e-133	437.0	COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,2K2BG@204457|Sphingomonadales	204457|Sphingomonadales	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
HFD1_k127_1063341_18	666685.R2APBS1_2528	3.449e-89	301.0	2A1SN@1|root,30Q1C@2|Bacteria,1NXN6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1063341_35	1090320.KB900605_gene1449	7.794e-12	71.0	28JTG@1|root,2ZTYG@2|Bacteria,1NI0X@1224|Proteobacteria,2TW60@28211|Alphaproteobacteria,2KEBR@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2793)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2793
HFD1_k127_1063341_24	1123267.JONN01000001_gene883	1.185e-68	242.0	COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2TXS0@28211|Alphaproteobacteria,2KEJB@204457|Sphingomonadales	204457|Sphingomonadales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HFD1_k127_1063341_12	1219035.NT2_07_00590	1.086e-134	443.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HFD1_k127_1063341_14	1123267.JONN01000001_gene611	1.462e-128	415.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,2K13W@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HFD1_k127_1063341_21	1123267.JONN01000001_gene612	6.174e-84	295.0	COG1218@1|root,COG1218@2|Bacteria,1QY18@1224|Proteobacteria,2TXFA@28211|Alphaproteobacteria,2KEHZ@204457|Sphingomonadales	204457|Sphingomonadales	P	PFAM inositol monophosphatase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HFD1_k127_113744_3	452662.SJA_C1-15210	6.661e-126	407.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,2K00M@204457|Sphingomonadales	204457|Sphingomonadales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HFD1_k127_113744_1	1123267.JONN01000001_gene481	9.731e-179	567.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2K130@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
HFD1_k127_113744_0	685778.AORL01000016_gene2292	3.349e-194	619.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K1UV@204457|Sphingomonadales	204457|Sphingomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HFD1_k127_113744_2	1123267.JONN01000001_gene479	2.079e-141	458.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2K11D@204457|Sphingomonadales	204457|Sphingomonadales	CO	Thiol disulfide interchange protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbC,DsbD,Thioredoxin_7
HFD1_k127_1145502_2	1123267.JONN01000002_gene100	3.891e-133	434.0	COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,2U1V8@28211|Alphaproteobacteria,2K2YY@204457|Sphingomonadales	204457|Sphingomonadales	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_1145502_1	685778.AORL01000021_gene574	6.105e-230	722.0	COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,2TUMS@28211|Alphaproteobacteria,2K1BD@204457|Sphingomonadales	204457|Sphingomonadales	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_1145502_0	1112216.JH594425_gene1321	3.808e-253	790.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K05X@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HFD1_k127_1183316_3	1123267.JONN01000001_gene2042	8.419e-85	286.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,2TW0V@28211|Alphaproteobacteria,2KCP4@204457|Sphingomonadales	204457|Sphingomonadales	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HFD1_k127_1183316_0	1123267.JONN01000001_gene2043	0.0	1270.0	COG1222@1|root,COG1222@2|Bacteria,1QTV4@1224|Proteobacteria,2U0Q7@28211|Alphaproteobacteria,2K0N9@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the AAA ATPase family	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HFD1_k127_1183316_2	1123267.JONN01000001_gene2045	1.269e-90	303.0	COG3963@1|root,COG3963@2|Bacteria,1R81B@1224|Proteobacteria,2U46R@28211|Alphaproteobacteria,2K2HK@204457|Sphingomonadales	204457|Sphingomonadales	I	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HFD1_k127_1183316_1	1123267.JONN01000001_gene2046	1.043e-141	461.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2U2TG@28211|Alphaproteobacteria,2K02V@204457|Sphingomonadales	204457|Sphingomonadales	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HFD1_k127_1183316_4	1123267.JONN01000001_gene2047	1.677e-52	190.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria,2K5I6@204457|Sphingomonadales	204457|Sphingomonadales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HFD1_k127_1235348_0	1123267.JONN01000001_gene2399	1.97e-234	736.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,2K0KD@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran
HFD1_k127_1235348_1	1123267.JONN01000001_gene2398	3.553e-148	477.0	COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,2U11S@28211|Alphaproteobacteria,2K36Y@204457|Sphingomonadales	204457|Sphingomonadales	MU	Outer membrane efflux protein	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	OEP
HFD1_k127_1262803_0	196490.AUEZ01000022_gene860	5.199e-80	289.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2VF55@28211|Alphaproteobacteria,3K3QA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HFD1_k127_1262803_1	1287276.X752_29455	1.594e-61	217.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,43JTB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HFD1_k127_1284635_1	1123267.JONN01000001_gene1061	2.136e-227	717.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2K1B6@204457|Sphingomonadales	204457|Sphingomonadales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HFD1_k127_1284635_0	1123267.JONN01000001_gene1060	0.0	1277.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2K1MX@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HFD1_k127_1358202_2	1123267.JONN01000002_gene337	5.722e-51	183.0	COG5622@1|root,COG5622@2|Bacteria,1RIEJ@1224|Proteobacteria,2U7UE@28211|Alphaproteobacteria,2K400@204457|Sphingomonadales	204457|Sphingomonadales	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HFD1_k127_1358202_0	1123267.JONN01000002_gene338	5.523e-200	630.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,2K02J@204457|Sphingomonadales	204457|Sphingomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HFD1_k127_1358202_1	1123267.JONN01000002_gene338	7.395e-93	307.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,2K02J@204457|Sphingomonadales	204457|Sphingomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HFD1_k127_1421131_0	1219035.NT2_01_02910	7.054e-243	753.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,2JZXI@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HFD1_k127_1421131_6	1123267.JONN01000001_gene666	6.156e-120	394.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,2JZXN@204457|Sphingomonadales	204457|Sphingomonadales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HFD1_k127_1421131_12	317655.Sala_0712	5.967e-17	87.0	COG0791@1|root,COG0791@2|Bacteria,1MW03@1224|Proteobacteria,2TSFG@28211|Alphaproteobacteria,2K27W@204457|Sphingomonadales	204457|Sphingomonadales	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HFD1_k127_1421131_9	1123267.JONN01000001_gene668	1.386e-58	206.0	COG1846@1|root,COG1846@2|Bacteria,1RJNN@1224|Proteobacteria,2U9SQ@28211|Alphaproteobacteria,2KDEK@204457|Sphingomonadales	204457|Sphingomonadales	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD1_k127_1421131_2	1123267.JONN01000001_gene669	1.018e-192	611.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,2JZV7@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the peptidase M17 family	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
HFD1_k127_1421131_8	366602.Caul_1957	5.549e-74	263.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TQJJ@28211|Alphaproteobacteria,2KF24@204458|Caulobacterales	204458|Caulobacterales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD1_k127_1421131_13	1096930.L284_12655	3.936e-14	75.0	29WB0@1|root,30HWH@2|Bacteria,1N3IB@1224|Proteobacteria,2UDM1@28211|Alphaproteobacteria,2K62V@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	ko:K06078	-	-	-	-	ko00000,ko01011	-	-	-	-
HFD1_k127_1421131_10	279238.Saro_2540	2.493e-56	206.0	COG1376@1|root,COG1376@2|Bacteria,1R7VK@1224|Proteobacteria,2UPBM@28211|Alphaproteobacteria,2K2IN@204457|Sphingomonadales	204457|Sphingomonadales	S	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1421131_1	1123269.NX02_11060	6.489e-231	721.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,2K1QA@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HFD1_k127_1421131_11	1223410.KN050846_gene73	3.722e-19	95.0	2EKX6@1|root,33EKQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1421131_7	1410620.SHLA_17c000450	3.1e-82	278.0	COG1335@1|root,COG1335@2|Bacteria,1RE3C@1224|Proteobacteria,2U0GC@28211|Alphaproteobacteria,4BGUR@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HFD1_k127_1421131_5	1096546.WYO_4941	8.847e-175	558.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,1JR0D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	rkpK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD1_k127_1421131_4	392499.Swit_1201	6.058e-178	569.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria,2K04J@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HFD1_k127_1421131_3	633149.Bresu_1163	1.06e-188	597.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TQVP@28211|Alphaproteobacteria,2KIDT@204458|Caulobacterales	204458|Caulobacterales	EGP	Sugar (and other) transporter	-	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
HFD1_k127_1421131_14	1123236.KB899383_gene2701	1.033e-12	78.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,465UW@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PKD,Peptidase_S8
HFD1_k127_145433_0	1123267.JONN01000001_gene1067	0.0	1407.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2K07V@204457|Sphingomonadales	204457|Sphingomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD1_k127_1550563_1	685035.ADAE01000002_gene2688	2.065e-41	155.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,2K0VM@204457|Sphingomonadales	204457|Sphingomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HFD1_k127_1550563_10	414684.RC1_3328	7.865e-05	48.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,2JTMH@204441|Rhodospirillales	204441|Rhodospirillales	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD1_k127_1550563_0	745310.G432_13305	3.416e-44	166.0	COG3791@1|root,COG3791@2|Bacteria,1N7AZ@1224|Proteobacteria,2UFKY@28211|Alphaproteobacteria,2K6EG@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1550563_9	1408224.SAMCCGM7_c4836	1.355e-05	48.0	COG3254@1|root,COG3254@2|Bacteria,1RIRS@1224|Proteobacteria,2UAT0@28211|Alphaproteobacteria,4BJKV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD1_k127_1550563_4	1282360.ABAC460_00880	3.326e-19	90.0	COG3254@1|root,COG3254@2|Bacteria,1RIRS@1224|Proteobacteria,2UAT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	rhamnose metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HFD1_k127_1550563_11	1381123.AYOD01000021_gene1962	8.98e-05	51.0	2DRXE@1|root,33DIB@2|Bacteria,1NJIC@1224|Proteobacteria,2UMJS@28211|Alphaproteobacteria,43QJE@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3606)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3606
HFD1_k127_1550563_6	1502850.FG91_03436	5.831e-13	69.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2UC22@28211|Alphaproteobacteria,2K541@204457|Sphingomonadales	204457|Sphingomonadales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HFD1_k127_1604801_1	452662.SJA_C1-21250	1.899e-83	278.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2K0H3@204457|Sphingomonadales	204457|Sphingomonadales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD1_k127_1604801_3	1449076.JOOE01000003_gene3194	1.564e-49	177.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,2K539@204457|Sphingomonadales	204457|Sphingomonadales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HFD1_k127_1604801_0	317655.Sala_0454	5.87e-141	462.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,2K152@204457|Sphingomonadales	204457|Sphingomonadales	V	Na -driven multidrug efflux pump	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HFD1_k127_1604801_2	1030157.AFMP01000044_gene1855	2.197e-65	232.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,2K1TY@204457|Sphingomonadales	204457|Sphingomonadales	OU	signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HFD1_k127_161371_9	1123267.JONN01000002_gene199	1.239e-12	70.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TRWS@28211|Alphaproteobacteria,2K02K@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD1_k127_161371_7	1174684.EBMC1_15734	6.411e-56	213.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TRWS@28211|Alphaproteobacteria,2K02K@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_161371_0	1123267.JONN01000002_gene198	2.063e-200	631.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2K2R1@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HFD1_k127_161371_6	1123267.JONN01000001_gene620	2.444e-57	201.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria,2K4F9@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HFD1_k127_161371_8	392499.Swit_0084	3.202e-37	140.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria,2K5WV@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HFD1_k127_161371_1	1123267.JONN01000001_gene618	3.539e-76	261.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria,2K0UT@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HFD1_k127_161371_3	1537715.JQFJ01000002_gene1055	5.713e-73	252.0	COG0625@1|root,COG0625@2|Bacteria,1RJVR@1224|Proteobacteria,2U5SU@28211|Alphaproteobacteria,2K42G@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N_3
HFD1_k127_161371_5	1545915.JROG01000004_gene2529	2.21e-57	205.0	COG0583@1|root,COG0583@2|Bacteria,1MXC9@1224|Proteobacteria,2TTTY@28211|Alphaproteobacteria,2K5KF@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_161371_2	1449076.JOOE01000003_gene3455	8.65e-74	255.0	COG1396@1|root,COG1396@2|Bacteria,1RKW7@1224|Proteobacteria,2U9PU@28211|Alphaproteobacteria,2K2H6@204457|Sphingomonadales	204457|Sphingomonadales	K	XRE family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HFD1_k127_161371_4	1123267.JONN01000001_gene614	5.38e-66	233.0	COG1846@1|root,COG1846@2|Bacteria,1N2Q4@1224|Proteobacteria,2UC5A@28211|Alphaproteobacteria,2K54U@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR
HFD1_k127_1613870_2	1219049.SP5_060_00380	1.569e-93	308.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K1AP@204457|Sphingomonadales	204457|Sphingomonadales	O	Peptidase family M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
HFD1_k127_1613870_0	1123267.JONN01000001_gene604	2.806e-214	670.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2K1PX@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_1613870_1	1479239.JQMU01000001_gene2823	3.784e-178	571.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K0FQ@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD1_k127_1613870_3	1192868.CAIU01000008_gene873	5.169e-21	93.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria,43P5X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD1_k127_1676720_3	359.CN09_14450	2.376e-92	314.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,4B737@82115|Rhizobiaceae	28211|Alphaproteobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_1676720_4	1123267.JONN01000001_gene1889	1.923e-55	199.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,2K5QM@204457|Sphingomonadales	204457|Sphingomonadales	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HFD1_k127_1676720_7	1123267.JONN01000001_gene1890	6.543e-19	89.0	293KA@1|root,2ZR29@2|Bacteria,1NKAC@1224|Proteobacteria,2UK1U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1676720_0	1123267.JONN01000001_gene1891	4.839e-137	440.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2TRT6@28211|Alphaproteobacteria,2K1NI@204457|Sphingomonadales	204457|Sphingomonadales	M	UTP-glucose-1-phosphate uridylyltransferase	ugpG	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HFD1_k127_1676720_6	1112212.JH584235_gene2152	7.615e-24	108.0	COG0745@1|root,COG0745@2|Bacteria,1NSIT@1224|Proteobacteria,2UR17@28211|Alphaproteobacteria,2K5ZF@204457|Sphingomonadales	204457|Sphingomonadales	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_1676720_1	1123267.JONN01000001_gene1893	2.381e-109	358.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,2K04Q@204457|Sphingomonadales	204457|Sphingomonadales	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HFD1_k127_1676720_2	1123267.JONN01000001_gene1894	3.696e-107	354.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria,2K0FZ@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
HFD1_k127_1676720_5	1090320.KB900605_gene1159	1.387e-30	132.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,2K3VX@204457|Sphingomonadales	204457|Sphingomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HFD1_k127_168758_0	1123269.NX02_00015	6.946e-144	463.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,2K24N@204457|Sphingomonadales	204457|Sphingomonadales	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HFD1_k127_168758_1	1234595.C725_0660	8.577e-135	448.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,4BPIC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HFD1_k127_168758_2	1123267.JONN01000001_gene1379	1.179e-61	216.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria,2K4QA@204457|Sphingomonadales	204457|Sphingomonadales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
HFD1_k127_168758_3	1123267.JONN01000001_gene1378	6.155e-14	73.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,2K0UG@204457|Sphingomonadales	204457|Sphingomonadales	S	import inner membrane translocase, subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HFD1_k127_1736883_2	492774.JQMB01000001_gene5719	8.865e-24	102.0	COG2141@1|root,COG2141@2|Bacteria,1MUVN@1224|Proteobacteria,2TR26@28211|Alphaproteobacteria,4B70B@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HFD1_k127_1736883_0	224911.27350330	4.708e-187	588.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MXYQ@1224|Proteobacteria,2TSX4@28211|Alphaproteobacteria,3JT1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_32
HFD1_k127_1736883_1	1205680.CAKO01000006_gene3341	3.64e-43	159.0	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2TU3M@28211|Alphaproteobacteria,2JQDY@204441|Rhodospirillales	204441|Rhodospirillales	GM	ATPases associated with a variety of cellular activities	-	-	3.6.3.38	ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
HFD1_k127_1745141_39	161528.ED21_22698	1.933e-16	79.0	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,2K7QY@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HFD1_k127_1745141_9	1123267.JONN01000001_gene2316	6.254e-147	471.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,2K1G3@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HFD1_k127_1745141_4	1123267.JONN01000001_gene2293	1.853e-178	565.0	COG2866@1|root,COG2866@2|Bacteria,1MUMN@1224|Proteobacteria,2TREN@28211|Alphaproteobacteria,2K01Q@204457|Sphingomonadales	204457|Sphingomonadales	E	Carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HFD1_k127_1745141_19	314266.SKA58_08931	6.39e-107	356.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2TSQ0@28211|Alphaproteobacteria,2K06W@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HFD1_k127_1745141_32	1123267.JONN01000001_gene2301	1.846e-57	206.0	COG2199@1|root,COG2199@2|Bacteria,1Q7FU@1224|Proteobacteria,2TRE7@28211|Alphaproteobacteria,2K6NS@204457|Sphingomonadales	204457|Sphingomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HFD1_k127_1745141_29	745310.G432_10005	1.541e-71	246.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,2K3Z8@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HFD1_k127_1745141_13	1123267.JONN01000001_gene2299	1.205e-140	455.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,2K0ZI@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HFD1_k127_1745141_1	1123267.JONN01000001_gene2297	0.0	1144.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2K05M@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD1_k127_1745141_40	1121124.JNIX01000015_gene2037	3.752e-10	66.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria,2UF5P@28211|Alphaproteobacteria,2KH28@204458|Caulobacterales	204458|Caulobacterales	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_1745141_22	460265.Mnod_3755	1.134e-97	332.0	COG1193@1|root,COG1352@1|root,COG2201@1|root,COG3920@1|root,COG1193@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2TW1K@28211|Alphaproteobacteria,1JTD7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	NT	PFAM CheB methylesterase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HWE_HK,PAS,PAS_10,PAS_3,PAS_4
HFD1_k127_1745141_7	1144307.PMI04_02905	1.606e-164	530.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2TSYS@28211|Alphaproteobacteria,2K1WY@204457|Sphingomonadales	204457|Sphingomonadales	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD1_k127_1745141_12	107635.AZUO01000001_gene1591	3.583e-144	462.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,36XAX@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_1745141_23	1207055.C100_05680	2.053e-97	324.0	COG1462@1|root,COG1462@2|Bacteria,1QURH@1224|Proteobacteria,2U2ZX@28211|Alphaproteobacteria,2K2HF@204457|Sphingomonadales	204457|Sphingomonadales	M	protein involved in formation of curli polymers	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,SH3_3
HFD1_k127_1745141_2	1123269.NX02_22215	0.0	1046.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,2K17X@204457|Sphingomonadales	204457|Sphingomonadales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HFD1_k127_1745141_3	1123267.JONN01000001_gene2357	1.515e-239	762.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HFD1_k127_1745141_36	1038867.AXAY01000011_gene5250	2.319e-39	148.0	2DNYI@1|root,32ZT2@2|Bacteria,1Q82Q@1224|Proteobacteria,2UV6B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	EthD domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1745141_21	420324.KI911965_gene1206	7.875e-100	329.0	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,2U0MC@28211|Alphaproteobacteria,1JZ93@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR,SCP2
HFD1_k127_1745141_30	1218075.BAYA01000005_gene1865	6.169e-71	251.0	COG1028@1|root,COG1028@2|Bacteria,1MUWP@1224|Proteobacteria,2W0EQ@28216|Betaproteobacteria,1K3JU@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_1745141_35	314266.SKA58_15357	6.957e-44	171.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,2K4W9@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HFD1_k127_1745141_5	501479.ACNW01000058_gene4416	2.063e-172	554.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	Glutaredoxin,PALP
HFD1_k127_1745141_34	279238.Saro_1236	2.144e-45	172.0	COG2197@1|root,COG2197@2|Bacteria,1RGH6@1224|Proteobacteria,2U81B@28211|Alphaproteobacteria,2K60U@204457|Sphingomonadales	204457|Sphingomonadales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HFD1_k127_1745141_31	1248917.ANFX01000023_gene1242	1.645e-67	250.0	COG4585@1|root,COG4585@2|Bacteria,1RKV1@1224|Proteobacteria,2U32D@28211|Alphaproteobacteria,2KDGC@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HFD1_k127_1745141_0	1123267.JONN01000001_gene2358	0.0	1195.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
HFD1_k127_1745141_6	1123267.JONN01000001_gene2355	1.432e-169	541.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U16F@28211|Alphaproteobacteria,2JZWJ@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HFD1_k127_1745141_10	1123267.JONN01000001_gene2356	5.672e-146	466.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria,2K1DU@204457|Sphingomonadales	204457|Sphingomonadales	T	Response regulator of the LytR AlgR family	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HFD1_k127_1745141_37	1323663.AROI01000023_gene1523	5.705e-23	103.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria	1224|Proteobacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_1745141_28	1144307.PMI04_03490	6.121e-81	276.0	2BS9I@1|root,32MB5@2|Bacteria,1RANC@1224|Proteobacteria,2U6RC@28211|Alphaproteobacteria,2K31S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HFD1_k127_1745141_16	1030157.AFMP01000028_gene2292	3.875e-114	372.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2K0QB@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_1745141_25	1123267.JONN01000001_gene1843	2.761e-87	296.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2K0AA@204457|Sphingomonadales	204457|Sphingomonadales	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HFD1_k127_1745141_17	1123368.AUIS01000006_gene634	1.887e-111	369.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,2NC0R@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HFD1_k127_1745141_18	1246459.KB898357_gene1484	5.604e-109	361.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,4BCJY@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD1_k127_1745141_15	1458357.BG58_13990	2.453e-130	425.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,1K00C@119060|Burkholderiaceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HFD1_k127_1745141_14	477184.KYC_14837	6.074e-139	455.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,3T1X9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HFD1_k127_1745141_24	1123269.NX02_10540	2.581e-96	326.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,2K1ZG@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_8
HFD1_k127_1745141_26	1449076.JOOE01000004_gene493	5.535e-83	282.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2U3CR@28211|Alphaproteobacteria,2K4EU@204457|Sphingomonadales	204457|Sphingomonadales	G	COG2513 PEP phosphonomutase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HFD1_k127_1745141_27	1449076.JOOE01000004_gene493	2.382e-82	280.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2U3CR@28211|Alphaproteobacteria,2K4EU@204457|Sphingomonadales	204457|Sphingomonadales	G	COG2513 PEP phosphonomutase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HFD1_k127_1745141_20	1123267.JONN01000001_gene2302	1.146e-101	346.0	COG1668@1|root,COG1668@2|Bacteria,1MWAS@1224|Proteobacteria,2TU2K@28211|Alphaproteobacteria,2K1E9@204457|Sphingomonadales	204457|Sphingomonadales	CP	ABC-type Na efflux pump, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD1_k127_1745141_11	1123267.JONN01000001_gene2303	8.109e-146	468.0	COG4152@1|root,COG4152@2|Bacteria,1QUPV@1224|Proteobacteria,2TW40@28211|Alphaproteobacteria,2JZWA@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_1745141_8	1219045.BV98_003643	1.952e-149	480.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2TR5E@28211|Alphaproteobacteria,2K0HW@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HFD1_k127_1745141_33	1123267.JONN01000001_gene2306	1.09e-53	192.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2K0DX@204457|Sphingomonadales	204457|Sphingomonadales	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD1_k127_1767830_0	1120705.FG95_01837	1.809e-239	745.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2K0GR@204457|Sphingomonadales	204457|Sphingomonadales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD1_k127_1767830_2	627192.SLG_05420	1.999e-109	366.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,2K0M2@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HFD1_k127_1767830_5	1123267.JONN01000001_gene1752	3.755e-61	212.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,2K4E3@204457|Sphingomonadales	204457|Sphingomonadales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HFD1_k127_1767830_3	1123270.ATUR01000003_gene1168	1.876e-71	242.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2U717@28211|Alphaproteobacteria,2K3VT@204457|Sphingomonadales	204457|Sphingomonadales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HFD1_k127_1767830_1	1123267.JONN01000001_gene1754	3.556e-196	619.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,2K0R2@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HFD1_k127_1767830_4	1041139.KB902578_gene5189	2.081e-71	251.0	COG2207@1|root,COG2207@2|Bacteria,1QKC9@1224|Proteobacteria,2U0K5@28211|Alphaproteobacteria,4B7R0@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
HFD1_k127_1767830_6	1043493.BBLU01000002_gene1760	1.5e-15	85.0	arCOG07533@1|root,2ZF5I@2|Bacteria,2IMPX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HFD1_k127_1767830_7	533247.CRD_01191	0.0003847	46.0	COG0484@1|root,COG0484@2|Bacteria,1G5QV@1117|Cyanobacteria,1HN5E@1161|Nostocales	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HFD1_k127_1786762_1	1123267.JONN01000001_gene2049	1.449e-297	916.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,2K15Q@204457|Sphingomonadales	204457|Sphingomonadales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD1_k127_1786762_7	1174684.EBMC1_11335	2.209e-09	62.0	2EG1C@1|root,339TC@2|Bacteria,1NGB5@1224|Proteobacteria,2UK68@28211|Alphaproteobacteria,2K7K2@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1786762_4	13689.BV96_00830	1.218e-48	179.0	COG1733@1|root,COG1733@2|Bacteria,1RIZT@1224|Proteobacteria,2U7SS@28211|Alphaproteobacteria,2K4MD@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD1_k127_1786762_5	1219045.BV98_001846	4.939e-46	170.0	2EBAW@1|root,335BJ@2|Bacteria,1N90V@1224|Proteobacteria,2UIYS@28211|Alphaproteobacteria,2K4JF@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5051
HFD1_k127_1786762_6	1123267.JONN01000001_gene2427	5.993e-18	87.0	2DCTG@1|root,2ZF9T@2|Bacteria,1N82Z@1224|Proteobacteria,2UGXI@28211|Alphaproteobacteria,2K6Y3@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1786762_0	1123267.JONN01000001_gene2428	0.0	1215.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,2K0I6@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HFD1_k127_1786762_3	1123267.JONN01000001_gene2430	1.053e-170	540.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2TQU5@28211|Alphaproteobacteria,2K1G9@204457|Sphingomonadales	204457|Sphingomonadales	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B
HFD1_k127_1786762_2	1123267.JONN01000001_gene2459	1.743e-206	647.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,2K0Q1@204457|Sphingomonadales	204457|Sphingomonadales	G	phosphomannomutase	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD1_k127_1828764_11	1123267.JONN01000002_gene53	1.771e-06	49.0	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria,2KCRH@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD1_k127_1828764_0	1123267.JONN01000002_gene52	6.825e-316	976.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2K017@204457|Sphingomonadales	204457|Sphingomonadales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HFD1_k127_1828764_1	1123267.JONN01000002_gene49	2.317e-189	601.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,2K246@204457|Sphingomonadales	204457|Sphingomonadales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
HFD1_k127_1828764_7	745310.G432_15285	3.921e-59	207.0	COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,2UEA0@28211|Alphaproteobacteria,2K55Z@204457|Sphingomonadales	204457|Sphingomonadales	U	Biopolymer transport protein	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HFD1_k127_1828764_8	1123267.JONN01000001_gene892	8.359e-55	196.0	COG0848@1|root,COG0848@2|Bacteria,1RH4U@1224|Proteobacteria,2UAMQ@28211|Alphaproteobacteria,2K4K9@204457|Sphingomonadales	204457|Sphingomonadales	U	Biopolymer	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HFD1_k127_1828764_2	1123267.JONN01000001_gene891	3.99e-112	370.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2TS4F@28211|Alphaproteobacteria,2K1P2@204457|Sphingomonadales	204457|Sphingomonadales	U	MotA TolQ ExbB proton channel	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HFD1_k127_1828764_10	1123267.JONN01000001_gene890	5.164e-44	168.0	COG0810@1|root,COG0810@2|Bacteria,1RCAG@1224|Proteobacteria,2U664@28211|Alphaproteobacteria,2K187@204457|Sphingomonadales	204457|Sphingomonadales	M	Periplasmic protein TonB, links inner and outer membranes	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_1828764_9	1123267.JONN01000001_gene889	1.014e-47	181.0	COG1539@1|root,COG1539@2|Bacteria,1PSIE@1224|Proteobacteria,2UD0R@28211|Alphaproteobacteria,2K4H4@204457|Sphingomonadales	204457|Sphingomonadales	H	dihydroneopterin aldolase	-	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HFD1_k127_1828764_4	1123267.JONN01000001_gene888	1.402e-80	275.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria,2K33T@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_1828764_5	745310.G432_15250	2.202e-77	262.0	COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria,2K0YC@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
HFD1_k127_1828764_6	1123267.JONN01000001_gene886	1.039e-67	238.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2K3ZW@204457|Sphingomonadales	204457|Sphingomonadales	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD1_k127_1828764_3	745310.G432_15240	2.568e-96	322.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,2K1SR@204457|Sphingomonadales	204457|Sphingomonadales	J	Polynucleotide adenylyltransferase	cca	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
HFD1_k127_1840750_1	1123267.JONN01000001_gene2053	1.372e-208	666.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTI2@28211|Alphaproteobacteria,2K0SD@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_1840750_2	1089551.KE386572_gene468	1.689e-96	327.0	COG1171@1|root,COG1171@2|Bacteria,1QVNS@1224|Proteobacteria,2TUHW@28211|Alphaproteobacteria,4BP87@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.15	ko:K01751	-	-	-	-	ko00000,ko01000	-	-	-	PALP
HFD1_k127_1840750_3	1123267.JONN01000001_gene2054	2.881e-91	304.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,2K0EN@204457|Sphingomonadales	204457|Sphingomonadales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HFD1_k127_1840750_5	1380394.JADL01000007_gene4454	1.787e-43	169.0	28NYT@1|root,2ZBVV@2|Bacteria,1RA1R@1224|Proteobacteria,2UBCK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HFD1_k127_1840750_0	1123267.JONN01000001_gene2057	0.0	1026.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2K14B@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HFD1_k127_1840750_6	1081640.AGFU01000028_gene2747	1.685e-24	104.0	COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,2UFFG@28211|Alphaproteobacteria,2K6RT@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
HFD1_k127_1840750_4	1123267.JONN01000001_gene638	2.676e-64	223.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria,2K1KY@204457|Sphingomonadales	204457|Sphingomonadales	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_1846564_0	1123267.JONN01000001_gene1908	4.356e-98	327.0	COG4993@1|root,COG4993@2|Bacteria,1N7DU@1224|Proteobacteria,2U6Z1@28211|Alphaproteobacteria,2K133@204457|Sphingomonadales	204457|Sphingomonadales	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1846564_1	745310.G432_09585	2.535e-57	220.0	COG5305@1|root,COG5305@2|Bacteria,1NAW4@1224|Proteobacteria,2VGR2@28211|Alphaproteobacteria,2K32Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1846564_2	392499.Swit_2968	1.536e-17	98.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UJHN@28211|Alphaproteobacteria,2K61Q@204457|Sphingomonadales	204457|Sphingomonadales	DTZ	EF-hand, calcium binding motif	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HFD1_k127_1848446_5	1112212.JH584235_gene1699	1.969e-77	261.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2K0V7@204457|Sphingomonadales	204457|Sphingomonadales	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HFD1_k127_1848446_2	1123267.JONN01000001_gene2433	5.773e-154	498.0	COG0438@1|root,COG0562@1|root,COG0438@2|Bacteria,COG0562@2|Bacteria,1MV4H@1224|Proteobacteria,2TTP4@28211|Alphaproteobacteria,2K2QF@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,Glyco_trans_1_4,NAD_binding_8
HFD1_k127_1848446_1	1123267.JONN01000001_gene2433	6.785e-192	605.0	COG0438@1|root,COG0562@1|root,COG0438@2|Bacteria,COG0562@2|Bacteria,1MV4H@1224|Proteobacteria,2TTP4@28211|Alphaproteobacteria,2K2QF@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,Glyco_trans_1_4,NAD_binding_8
HFD1_k127_1848446_4	1123267.JONN01000001_gene2435	4.925e-110	361.0	COG0406@1|root,COG0406@2|Bacteria,1RAPQ@1224|Proteobacteria,2U0U1@28211|Alphaproteobacteria,2K12D@204457|Sphingomonadales	204457|Sphingomonadales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HFD1_k127_1848446_0	1123267.JONN01000001_gene2437	3.507e-213	672.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,2K07D@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HFD1_k127_1848446_6	1123267.JONN01000001_gene2438	1.47e-32	128.0	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,2K5Z1@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0335 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2312
HFD1_k127_1848446_3	555793.WSK_0367	3e-123	398.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,2K0KW@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HFD1_k127_1862492_11	1123267.JONN01000001_gene1702	1.16e-51	188.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,2K3ZK@204457|Sphingomonadales	204457|Sphingomonadales	O	Protein-disulfide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
HFD1_k127_1862492_5	1123267.JONN01000001_gene1701	3.589e-180	575.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,2K0E5@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16
HFD1_k127_1862492_1	1123267.JONN01000001_gene456	6.9e-319	995.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,2K00N@204457|Sphingomonadales	204457|Sphingomonadales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HFD1_k127_1862492_3	745310.G432_09420	2.563e-210	669.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,2K20G@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HFD1_k127_1862492_2	1123267.JONN01000001_gene497	7.08e-305	946.0	COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,2TQNS@28211|Alphaproteobacteria,2K1X3@204457|Sphingomonadales	204457|Sphingomonadales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HFD1_k127_1862492_7	1219035.NT2_05_02660	1.051e-102	344.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2K0NK@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HFD1_k127_1862492_9	1122970.AUHC01000007_gene1762	3.086e-75	261.0	COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,2K1HN@204457|Sphingomonadales	204457|Sphingomonadales	G	Aldolase	eda	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HFD1_k127_1862492_10	1123267.JONN01000001_gene457	1.192e-67	241.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,2K2BU@204457|Sphingomonadales	204457|Sphingomonadales	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HFD1_k127_1862492_0	1123267.JONN01000001_gene458	0.0	1206.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2K0P9@204457|Sphingomonadales	204457|Sphingomonadales	M	Penicillin-binding Protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
HFD1_k127_1862492_4	1123267.JONN01000001_gene459	2.404e-202	634.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,2K0B2@204457|Sphingomonadales	204457|Sphingomonadales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD1_k127_1862492_8	1123267.JONN01000001_gene460	8.797e-85	286.0	COG2518@1|root,COG2518@2|Bacteria,1QYXY@1224|Proteobacteria,2TY17@28211|Alphaproteobacteria,2KEKI@204457|Sphingomonadales	204457|Sphingomonadales	O	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HFD1_k127_1862492_12	1123267.JONN01000001_gene467	9.987e-37	142.0	COG2003@1|root,COG2003@2|Bacteria,1N88N@1224|Proteobacteria,2UY1Y@28211|Alphaproteobacteria,2K6V2@204457|Sphingomonadales	204457|Sphingomonadales	L	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HFD1_k127_1862492_6	1123267.JONN01000001_gene466	2.725e-116	377.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,2K0PF@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HFD1_k127_1890112_8	392499.Swit_4483	9.301e-11	63.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,2K17B@204457|Sphingomonadales	204457|Sphingomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD1_k127_1890112_5	1030157.AFMP01000049_gene113	1.213e-23	103.0	COG5336@1|root,COG5336@2|Bacteria,1N2ME@1224|Proteobacteria,2UCBR@28211|Alphaproteobacteria,2K62W@204457|Sphingomonadales	204457|Sphingomonadales	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HFD1_k127_1890112_2	1123267.JONN01000002_gene216	7.511e-52	198.0	2ANQE@1|root,31DQ0@2|Bacteria,1MWJD@1224|Proteobacteria,2U7P7@28211|Alphaproteobacteria,2K5A1@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4163)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4163
HFD1_k127_1890112_3	1123267.JONN01000002_gene215	1.179e-33	137.0	COG3784@1|root,COG3784@2|Bacteria,1Q09W@1224|Proteobacteria,2UCIH@28211|Alphaproteobacteria,2K5RZ@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09978	-	-	-	-	ko00000	-	-	-	DUF1318
HFD1_k127_1890112_7	1219045.BV98_002433	9.822e-14	81.0	2AKQN@1|root,31BHD@2|Bacteria,1Q7C6@1224|Proteobacteria,2UJNT@28211|Alphaproteobacteria,2K6TW@204457|Sphingomonadales	204457|Sphingomonadales	S	YnbE-like lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_19
HFD1_k127_1890112_0	1123267.JONN01000002_gene213	0.0	1078.0	COG2911@1|root,COG2911@2|Bacteria,1R6VP@1224|Proteobacteria,2U46Q@28211|Alphaproteobacteria,2KCIH@204457|Sphingomonadales	204457|Sphingomonadales	S	Dicarboxylate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctA-YdbH
HFD1_k127_1890112_1	1123267.JONN01000002_gene212	1.118e-66	236.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,2K0WQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HFD1_k127_1890112_4	1123267.JONN01000002_gene212	1.045e-23	108.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,2K0WQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HFD1_k127_1890112_6	317655.Sala_1036	1.475e-20	91.0	COG5455@1|root,COG5455@2|Bacteria,1MYUG@1224|Proteobacteria,2UBNQ@28211|Alphaproteobacteria,2KE3F@204457|Sphingomonadales	204457|Sphingomonadales	S	Nickel/cobalt transporter regulator	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
HFD1_k127_1893324_0	1114964.L485_20255	2.513e-274	848.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,2K0R8@204457|Sphingomonadales	204457|Sphingomonadales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HFD1_k127_1893324_1	1123267.JONN01000001_gene1200	7.558e-197	624.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,2K1R8@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD1_k127_1913802_2	626887.J057_01760	4.516e-36	143.0	2C69U@1|root,32STX@2|Bacteria,1RDUC@1224|Proteobacteria	1224|Proteobacteria	S	Holin of 3TMs, for gene-transfer release	-	-	-	-	-	-	-	-	-	-	-	-	GTA_holin_3TM
HFD1_k127_1913802_0	1304878.AUGD01000027_gene1096	7.075e-166	527.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,3JYE2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HFD1_k127_1913802_1	397945.Aave_2936	7.894e-46	167.0	COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2VU5U@28216|Betaproteobacteria,4AI0D@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HFD1_k127_1913802_3	1134912.AJTV01000008_gene1878	9.796e-27	111.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,36ZGF@31993|Methylocystaceae	28211|Alphaproteobacteria	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HFD1_k127_1940462_1	1304885.AUEY01000005_gene814	2.872e-60	218.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,2MI98@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HFD1_k127_1940462_2	859657.RPSI07_2904	3.959e-19	90.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,1K99W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HFD1_k127_1940462_0	555079.Toce_0176	1.44e-153	498.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,42EYY@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HFD1_k127_1958557_16	1335760.ASTG01000002_gene2183	6.879e-24	100.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,2K0W6@204457|Sphingomonadales	204457|Sphingomonadales	V	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Amidase_2
HFD1_k127_1958557_9	1123267.JONN01000001_gene1107	6.828e-79	266.0	COG2214@1|root,COG2214@2|Bacteria,1RHBK@1224|Proteobacteria,2TYF4@28211|Alphaproteobacteria,2KEMB@204457|Sphingomonadales	204457|Sphingomonadales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HFD1_k127_1958557_11	1123267.JONN01000001_gene1109	2.707e-58	205.0	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,2U9A2@28211|Alphaproteobacteria,2K4H9@204457|Sphingomonadales	204457|Sphingomonadales	S	SufE protein probably involved in Fe-S center assembly	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
HFD1_k127_1958557_21	1030157.AFMP01000008_gene3220	7.985e-07	54.0	2DNTE@1|root,32Z25@2|Bacteria,1NK1C@1224|Proteobacteria,2UJRY@28211|Alphaproteobacteria,2K7CU@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1958557_18	1123267.JONN01000001_gene1111	7.709e-11	66.0	2B2V7@1|root,31VFS@2|Bacteria,1NBPZ@1224|Proteobacteria,2UGTR@28211|Alphaproteobacteria,2KCC5@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1958557_13	1123267.JONN01000001_gene1112	4.546e-42	160.0	COG1983@1|root,COG1983@2|Bacteria,1RHXA@1224|Proteobacteria,2UA9Z@28211|Alphaproteobacteria,2K54F@204457|Sphingomonadales	204457|Sphingomonadales	KT	PspC domain	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HFD1_k127_1958557_14	1123267.JONN01000001_gene1113	7.383e-32	126.0	2EH78@1|root,33AZ2@2|Bacteria,1N7AP@1224|Proteobacteria,2UGJI@28211|Alphaproteobacteria,2K6SQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Phage shock protein B	pspB	-	-	ko:K03970	-	-	-	-	ko00000,ko02048	-	-	-	PspB
HFD1_k127_1958557_7	1123267.JONN01000001_gene1114	9.26e-91	303.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,2U6CN@28211|Alphaproteobacteria,2K2DP@204457|Sphingomonadales	204457|Sphingomonadales	KT	Phage shock protein A	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HFD1_k127_1958557_0	1123267.JONN01000001_gene1115	7.603e-165	525.0	COG3829@1|root,COG3829@2|Bacteria,1QUPP@1224|Proteobacteria,2TR58@28211|Alphaproteobacteria,2K0CK@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Sigma54_activat
HFD1_k127_1958557_10	1449076.JOOE01000002_gene900	1.532e-72	251.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,2U7B1@28211|Alphaproteobacteria,2K410@204457|Sphingomonadales	204457|Sphingomonadales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HFD1_k127_1958557_8	1449076.JOOE01000002_gene899	3.213e-87	292.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,2K112@204457|Sphingomonadales	204457|Sphingomonadales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HFD1_k127_1958557_3	1123267.JONN01000001_gene1120	2.386e-129	416.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria,2JZWT@204457|Sphingomonadales	204457|Sphingomonadales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HFD1_k127_1958557_2	1123267.JONN01000001_gene1121	2.052e-140	453.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria,2K0Z9@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_1958557_6	1123267.JONN01000001_gene1122	1.376e-95	317.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria,2K4N8@204457|Sphingomonadales	204457|Sphingomonadales	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HFD1_k127_1958557_1	1123267.JONN01000001_gene1123	1.17e-162	515.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria,2K03J@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HFD1_k127_1958557_4	1123269.NX02_13045	9.697e-123	406.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria,2K0WZ@204457|Sphingomonadales	204457|Sphingomonadales	J	2-methylthioadenine	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
HFD1_k127_1958557_12	1461693.ATO10_08202	3.67e-52	196.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HFD1_k127_1958557_5	1356854.N007_18890	1.194e-108	367.0	COG4638@1|root,COG4638@2|Bacteria,1UZWG@1239|Firmicutes,4HBGQ@91061|Bacilli	91061|Bacilli	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HFD1_k127_1958557_15	1123267.JONN01000001_gene1125	5.459e-29	123.0	2BPFV@1|root,32I85@2|Bacteria,1Q8G2@1224|Proteobacteria,2VEP2@28211|Alphaproteobacteria,2K6XS@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_1958557_17	1041146.ATZB01000007_gene2878	1.279e-22	101.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
HFD1_k127_2000501_0	1502850.FG91_00756	2.305e-117	383.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria,2KCTI@204457|Sphingomonadales	204457|Sphingomonadales	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_2000501_4	1123269.NX02_27640	7.981e-57	206.0	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,2U1VW@28211|Alphaproteobacteria,2K5RK@204457|Sphingomonadales	204457|Sphingomonadales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HFD1_k127_2000501_2	450851.PHZ_c1673	1.848e-80	279.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2000501_3	1207075.PputUW4_02088	4.747e-73	276.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,1RSNG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HFD1_k127_2000501_1	1123269.NX02_27645	1.3e-105	376.0	COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1QU9N@1224|Proteobacteria,2TW44@28211|Alphaproteobacteria,2K7FJ@204457|Sphingomonadales	204457|Sphingomonadales	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HFD1_k127_2000501_5	1123269.NX02_07310	6.158e-16	76.0	COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria,2K0A1@204457|Sphingomonadales	204457|Sphingomonadales	S	GcrA cell cycle regulator	-	-	-	ko:K13583	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	GcrA
HFD1_k127_2006648_2	1123267.JONN01000001_gene1454	2.237e-192	613.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,2K16M@204457|Sphingomonadales	204457|Sphingomonadales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HFD1_k127_2006648_3	1123267.JONN01000001_gene1452	1.223e-166	528.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria,2K03P@204457|Sphingomonadales	204457|Sphingomonadales	NU	type II secretion system protein	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD1_k127_2006648_8	1123267.JONN01000001_gene1451	5.007e-132	428.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,2K0B5@204457|Sphingomonadales	204457|Sphingomonadales	U	pilus assembly protein TadB	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HFD1_k127_2006648_0	1123267.JONN01000001_gene1450	9.334e-232	722.0	COG2204@1|root,COG4963@1|root,COG2204@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,2K0BT@204457|Sphingomonadales	204457|Sphingomonadales	TU	Flp pilus assembly protein, ATPase CpaE	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	CbiA,ParA
HFD1_k127_2006648_15	1123267.JONN01000001_gene1449	6.747e-52	193.0	COG5461@1|root,COG5461@2|Bacteria,1REYP@1224|Proteobacteria,2U8J3@28211|Alphaproteobacteria,2K5AY@204457|Sphingomonadales	204457|Sphingomonadales	N	Pilus assembly protein CpaD	cpaD	-	-	ko:K02281	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Pilus_CpaD
HFD1_k127_2006648_6	1112212.JH584235_gene1284	8.558e-151	494.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,2K0ZQ@204457|Sphingomonadales	204457|Sphingomonadales	U	Belongs to the GSP D family	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HFD1_k127_2006648_7	1123267.JONN01000001_gene1447	4.599e-141	456.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2TTPE@28211|Alphaproteobacteria,2K08W@204457|Sphingomonadales	204457|Sphingomonadales	U	Pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HFD1_k127_2006648_16	1331060.RLDS_17115	4.813e-43	163.0	COG4960@1|root,COG4960@2|Bacteria,1RAYG@1224|Proteobacteria,2UJT9@28211|Alphaproteobacteria,2K6EK@204457|Sphingomonadales	204457|Sphingomonadales	OU	peptidase	cpaA	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
HFD1_k127_2006648_9	1123267.JONN01000001_gene1446	6.948e-124	406.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2JZYS@204457|Sphingomonadales	204457|Sphingomonadales	E	Oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HFD1_k127_2006648_12	1090318.ATTI01000001_gene1495	3.786e-69	238.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,2K3YC@204457|Sphingomonadales	204457|Sphingomonadales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HFD1_k127_2006648_4	1123267.JONN01000001_gene1444	7.047e-155	494.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,2K1ES@204457|Sphingomonadales	204457|Sphingomonadales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HFD1_k127_2006648_13	1123267.JONN01000001_gene1443	1.121e-66	234.0	2B5IK@1|root,31YDD@2|Bacteria,1RAZF@1224|Proteobacteria,2U6F0@28211|Alphaproteobacteria,2K43H@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2006648_5	1123267.JONN01000001_gene1440	8.248e-153	491.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,2K1GI@204457|Sphingomonadales	204457|Sphingomonadales	E	Glycine cleavage system T protein	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HFD1_k127_2006648_14	1123267.JONN01000001_gene1439	1.326e-61	217.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,2K5E0@204457|Sphingomonadales	204457|Sphingomonadales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HFD1_k127_2006648_10	1123267.JONN01000001_gene1438	1.817e-103	341.0	COG4106@1|root,COG4106@2|Bacteria,1R04W@1224|Proteobacteria,2U5VR@28211|Alphaproteobacteria,2K298@204457|Sphingomonadales	204457|Sphingomonadales	S	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_2006648_1	1123267.JONN01000001_gene1437	5.577e-225	704.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria,2K0IW@204457|Sphingomonadales	204457|Sphingomonadales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HFD1_k127_2006648_11	1449076.JOOE01000001_gene2947	2.054e-74	253.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,2K1GP@204457|Sphingomonadales	204457|Sphingomonadales	E	Glycine dehydrogenase (aminomethyl-transferring)	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HFD1_k127_2019740_10	1123267.JONN01000001_gene2239	1.083e-55	196.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,2K0E4@204457|Sphingomonadales	204457|Sphingomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD1_k127_2019740_5	1123267.JONN01000001_gene2240	2.727e-112	369.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2U1MH@28211|Alphaproteobacteria,2K0EG@204457|Sphingomonadales	204457|Sphingomonadales	L	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HFD1_k127_2019740_3	1007104.SUS17_3009	7.917e-158	512.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2K182@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HFD1_k127_2019740_4	1123267.JONN01000001_gene2242	4.029e-126	407.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,2K0YX@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC-type (Unclassified) transport system, ATPase component	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HFD1_k127_2019740_9	1123267.JONN01000001_gene2243	3.548e-63	227.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,2K3YP@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HFD1_k127_2019740_8	1123267.JONN01000001_gene2244	3.099e-67	237.0	COG5375@1|root,COG5375@2|Bacteria,1NMV8@1224|Proteobacteria,2VCS4@28211|Alphaproteobacteria,2K34V@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein conserved in bacteria	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HFD1_k127_2019740_7	1123267.JONN01000001_gene2245	2.114e-101	336.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria,2K0FG@204457|Sphingomonadales	204457|Sphingomonadales	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
HFD1_k127_2019740_6	194867.ALBQ01000014_gene456	6.593e-107	351.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,2JZZ2@204457|Sphingomonadales	204457|Sphingomonadales	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD1_k127_2019740_2	1123269.NX02_19010	2.336e-165	538.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K0U5@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase S10 serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
HFD1_k127_2019740_1	1112216.JH594425_gene1603	1.099e-169	543.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_2019740_0	1123267.JONN01000001_gene2256	4.839e-214	670.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,2K08Z@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP-dependent DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HFD1_k127_2024486_2	517722.AEUE01000001_gene2507	1.918e-22	98.0	COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,2U1V8@28211|Alphaproteobacteria,2K2YY@204457|Sphingomonadales	204457|Sphingomonadales	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_2024486_1	1123267.JONN01000002_gene101	3.294e-67	235.0	COG4094@1|root,COG4094@2|Bacteria,1RDF9@1224|Proteobacteria,2U7NM@28211|Alphaproteobacteria,2K2CX@204457|Sphingomonadales	204457|Sphingomonadales	S	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
HFD1_k127_2024486_0	1123267.JONN01000002_gene102	5.678e-182	575.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,2JZV4@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD1_k127_2045338_0	1123267.JONN01000001_gene1770	1.67e-233	734.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2K1DA@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD1_k127_2045338_2	1123267.JONN01000001_gene1771	2.431e-135	439.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,2K18K@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HFD1_k127_2045338_3	1123267.JONN01000001_gene1772	7.804e-110	363.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,2JZVK@204457|Sphingomonadales	204457|Sphingomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HFD1_k127_2045338_1	1123267.JONN01000001_gene1773	4.791e-206	655.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2TREW@28211|Alphaproteobacteria,2K043@204457|Sphingomonadales	204457|Sphingomonadales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HFD1_k127_2045338_5	1236976.JCM16418_1495	1.011e-12	74.0	COG3797@1|root,COG3797@2|Bacteria,1V4KG@1239|Firmicutes,4HIGT@91061|Bacilli,26WVR@186822|Paenibacillaceae	91061|Bacilli	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HFD1_k127_2045338_4	318586.Pden_1076	8.412e-16	79.0	COG3797@1|root,COG3797@2|Bacteria,1PUJU@1224|Proteobacteria,2V1G4@28211|Alphaproteobacteria,2PY8P@265|Paracoccus	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HFD1_k127_2067474_2	1123267.JONN01000001_gene1378	6.958e-14	71.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,2K0UG@204457|Sphingomonadales	204457|Sphingomonadales	S	import inner membrane translocase, subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HFD1_k127_2067474_0	1123267.JONN01000001_gene1377	3.803e-148	480.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2TS5S@28211|Alphaproteobacteria,2K0IG@204457|Sphingomonadales	204457|Sphingomonadales	M	membrane-bound lytic murein transglycosylase	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HFD1_k127_2067474_1	1090320.KB900605_gene3223	6.986e-30	125.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,2K652@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HFD1_k127_2067474_3	1123267.JONN01000001_gene1375	9.521e-12	66.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K2DF@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HFD1_k127_209769_9	392499.Swit_1337	5.029e-51	182.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,2K52X@204457|Sphingomonadales	204457|Sphingomonadales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HFD1_k127_209769_5	1030157.AFMP01000051_gene321	4.897e-102	339.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,2K10Y@204457|Sphingomonadales	204457|Sphingomonadales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HFD1_k127_209769_13	1123267.JONN01000001_gene1538	1.246e-23	101.0	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,2K6V8@204457|Sphingomonadales	204457|Sphingomonadales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HFD1_k127_209769_7	1123267.JONN01000001_gene1537	7.443e-77	261.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,2K40W@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HFD1_k127_209769_1	1123267.JONN01000001_gene1536	5.993e-218	683.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,2JZY0@204457|Sphingomonadales	204457|Sphingomonadales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HFD1_k127_209769_6	1219049.SP5_100_00010	4.832e-101	333.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2JZW8@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HFD1_k127_209769_8	1123267.JONN01000001_gene1533	7.357e-58	205.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,2K4ET@204457|Sphingomonadales	204457|Sphingomonadales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HFD1_k127_209769_2	1081640.AGFU01000063_gene3745	6.047e-188	597.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2K0VP@204457|Sphingomonadales	204457|Sphingomonadales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
HFD1_k127_209769_15	1209984.BN978_05111	0.000458	48.0	29YQU@1|root,30KKN@2|Bacteria,2HSNG@201174|Actinobacteria,23D81@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_209769_3	1112212.JH584235_gene3566	9.505e-126	406.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,2TTZV@28211|Alphaproteobacteria,2K1FS@204457|Sphingomonadales	204457|Sphingomonadales	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HFD1_k127_209769_4	317655.Sala_0591	2.002e-113	368.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,2K0NC@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HFD1_k127_209769_10	745310.G432_17765	1.419e-36	139.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2K5YV@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HFD1_k127_209769_11	426117.M446_3788	4.271e-31	129.0	COG2149@1|root,COG2149@2|Bacteria,1RJJ7@1224|Proteobacteria,2UA2E@28211|Alphaproteobacteria,1JV00@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HFD1_k127_209769_0	1123267.JONN01000001_gene1733	0.0	1063.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2K0RP@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HFD1_k127_209769_12	69395.JQLZ01000004_gene783	4.81e-24	102.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,2KFZ9@204458|Caulobacterales	204458|Caulobacterales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD1_k127_212705_2	1301098.PKB_1761	3.759e-14	74.0	COG2149@1|root,COG2149@2|Bacteria,1N173@1224|Proteobacteria,1SC54@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HFD1_k127_212705_1	1229172.JQFA01000004_gene1462	8.204e-17	83.0	298UM@1|root,2ZVYT@2|Bacteria,1GGRY@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_212705_0	107636.JQNK01000008_gene4265	5.513e-61	217.0	COG1309@1|root,COG1309@2|Bacteria,1NBMY@1224|Proteobacteria,2UX53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD1_k127_212705_3	929556.Solca_0145	5.396e-12	69.0	2E5NA@1|root,330D3@2|Bacteria,4NUZF@976|Bacteroidetes,1IU4P@117747|Sphingobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HFD1_k127_216733_2	443598.AUFA01000004_gene5431	9.002e-29	121.0	COG3467@1|root,COG3467@2|Bacteria,1RAZD@1224|Proteobacteria,2TXIF@28211|Alphaproteobacteria,3K6W8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD1_k127_216733_0	1449076.JOOE01000003_gene3769	5.326e-44	164.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,2KD85@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HFD1_k127_216733_1	1449076.JOOE01000003_gene3772	1.83e-42	163.0	COG3832@1|root,COG3832@2|Bacteria,1RHJJ@1224|Proteobacteria,2U6I2@28211|Alphaproteobacteria,2K7CQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HFD1_k127_216733_3	1287276.X752_18920	6.944e-11	66.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,2U5UG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	MA20_19505	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD1_k127_217973_2	234267.Acid_2317	9.747e-82	284.0	COG1171@1|root,COG1171@2|Bacteria,3Y2RI@57723|Acidobacteria	57723|Acidobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HFD1_k127_217973_4	1408224.SAMCCGM7_c4360	6.343e-19	87.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,2UGKQ@28211|Alphaproteobacteria,4BGVN@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HFD1_k127_217973_0	1123267.JONN01000002_gene224	3.095e-114	373.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,2K0UE@204457|Sphingomonadales	204457|Sphingomonadales	I	enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HFD1_k127_217973_3	1088721.NSU_3805	1.686e-39	151.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2U5QW@28211|Alphaproteobacteria,2K6MG@204457|Sphingomonadales	204457|Sphingomonadales	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HFD1_k127_217973_1	1123267.JONN01000002_gene22	9.162e-89	297.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2TTC4@28211|Alphaproteobacteria,2K27K@204457|Sphingomonadales	204457|Sphingomonadales	S	Phenylacetic acid catabolic protein	-	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD1_k127_2200394_2	314266.SKA58_15872	7.044e-23	105.0	COG3895@1|root,COG3895@2|Bacteria,1N8G9@1224|Proteobacteria,2UQIF@28211|Alphaproteobacteria,2K4MY@204457|Sphingomonadales	204457|Sphingomonadales	S	Periplasmic Protein	-	-	-	-	-	-	-	-	-	-	-	-	MliC
HFD1_k127_2200394_3	1304878.AUGD01000009_gene6263	2.375e-14	81.0	2EGHB@1|root,33A9F@2|Bacteria,1N1DH@1224|Proteobacteria,2UEKD@28211|Alphaproteobacteria,3K0Q5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
HFD1_k127_2200394_0	1123267.JONN01000001_gene1869	7.476e-96	323.0	COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,2TVBG@28211|Alphaproteobacteria,2K0J7@204457|Sphingomonadales	204457|Sphingomonadales	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_2200394_1	1123267.JONN01000001_gene1868	4.038e-57	201.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,2K0EJ@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD1_k127_2228045_2	1123267.JONN01000001_gene553	1.268e-16	79.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,Peptidase_C39_2,Rhomboid,TPR_16,TPR_19,TPR_8
HFD1_k127_2228045_0	1112212.JH584235_gene1303	2.969e-190	599.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,2K213@204457|Sphingomonadales	204457|Sphingomonadales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HFD1_k127_2228045_3	1173024.KI912150_gene1438	1.66e-05	49.0	2EH9Q@1|root,33B1J@2|Bacteria,1GAX5@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2228045_1	1123267.JONN01000001_gene1432	1.64e-26	113.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2U7BJ@28211|Alphaproteobacteria,2K70Y@204457|Sphingomonadales	204457|Sphingomonadales	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HFD1_k127_2306477_3	745310.G432_09480	7.177e-166	529.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,2K0R3@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HFD1_k127_2306477_2	1123267.JONN01000001_gene2130	1.163e-194	623.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,2K0M4@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HFD1_k127_2306477_17	1114964.L485_07740	6.097e-06	56.0	2BP1S@1|root,32HSA@2|Bacteria,1P9NT@1224|Proteobacteria,2UXHU@28211|Alphaproteobacteria,2K79D@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2306477_4	1123267.JONN01000001_gene2133	4.588e-144	466.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,2K10R@204457|Sphingomonadales	204457|Sphingomonadales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HFD1_k127_2306477_8	1123267.JONN01000001_gene2134	1.34e-84	284.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,2K0MU@204457|Sphingomonadales	204457|Sphingomonadales	H	Riboflavin synthase	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HFD1_k127_2306477_1	1123267.JONN01000001_gene2135	8.083e-226	704.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,2K1FG@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HFD1_k127_2306477_11	1090320.KB900605_gene1277	1.522e-57	206.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria,2K4FR@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HFD1_k127_2306477_5	1123267.JONN01000001_gene2212	1.419e-136	444.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,2K0I7@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH flavin	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HFD1_k127_2306477_6	1123267.JONN01000001_gene2213	3.35e-111	366.0	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,2K1CY@204457|Sphingomonadales	204457|Sphingomonadales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_2306477_9	1123267.JONN01000001_gene2214	1.179e-73	253.0	COG5590@1|root,COG5590@2|Bacteria,1MW25@1224|Proteobacteria,2U9ST@28211|Alphaproteobacteria,2K3VY@204457|Sphingomonadales	204457|Sphingomonadales	S	RpsU-divergently transcribed	-	-	-	ko:K18587	-	-	-	-	ko00000	-	-	-	COQ9
HFD1_k127_2306477_16	1123267.JONN01000001_gene2215	4.049e-25	106.0	COG1918@1|root,COG1918@2|Bacteria,1N7XK@1224|Proteobacteria,2UI27@28211|Alphaproteobacteria,2K6S7@204457|Sphingomonadales	204457|Sphingomonadales	P	Fe2 transport system protein A	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HFD1_k127_2306477_0	1123267.JONN01000001_gene2216	6.489e-284	884.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2TQSU@28211|Alphaproteobacteria,2K0AQ@204457|Sphingomonadales	204457|Sphingomonadales	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HFD1_k127_2306477_10	1123267.JONN01000001_gene2217	5.254e-62	217.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,2K464@204457|Sphingomonadales	204457|Sphingomonadales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HFD1_k127_2306477_12	1123267.JONN01000001_gene2218	3.464e-54	195.0	COG1399@1|root,COG1399@2|Bacteria,1N7C2@1224|Proteobacteria,2UC4J@28211|Alphaproteobacteria,2K4K6@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized ACR, COG1399	-	-	-	-	-	-	-	-	-	-	-	-	DUF177
HFD1_k127_2306477_14	1123267.JONN01000001_gene2219	6.486e-34	144.0	COG5452@1|root,COG5452@2|Bacteria,1N12T@1224|Proteobacteria,2UCES@28211|Alphaproteobacteria,2K5B4@204457|Sphingomonadales	204457|Sphingomonadales	S	Ubiquinol-cytochrome C chaperone	-	-	-	ko:K17662	-	-	-	-	ko00000,ko03029	-	-	-	Ubiq_cyt_C_chap
HFD1_k127_2306477_13	1123267.JONN01000001_gene2220	7.397e-47	173.0	COG2913@1|root,COG2913@2|Bacteria,1RHYM@1224|Proteobacteria,2UBU9@28211|Alphaproteobacteria,2K4H5@204457|Sphingomonadales	204457|Sphingomonadales	J	Small protein A (tmRNA-binding)	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
HFD1_k127_2306477_7	1123267.JONN01000001_gene2221	9.112e-108	354.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2TRXV@28211|Alphaproteobacteria,2K1B3@204457|Sphingomonadales	204457|Sphingomonadales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HFD1_k127_2306477_15	1123267.JONN01000001_gene2222	1.082e-27	116.0	COG0520@1|root,COG0520@2|Bacteria,1Q7AQ@1224|Proteobacteria,2VCMD@28211|Alphaproteobacteria,2K2Q9@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD1_k127_2307064_20	392499.Swit_4093	8.147e-17	81.0	COG1286@1|root,COG1286@2|Bacteria,1REF7@1224|Proteobacteria,2VA4D@28211|Alphaproteobacteria,2K52S@204457|Sphingomonadales	204457|Sphingomonadales	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HFD1_k127_2307064_1	1123267.JONN01000001_gene1268	6.949e-192	607.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,2K19T@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HFD1_k127_2307064_18	1112216.JH594425_gene3228	6.32e-28	121.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria,2U74A@28211|Alphaproteobacteria,2K54B@204457|Sphingomonadales	204457|Sphingomonadales	C	NifU homolog involved in Fe-S cluster formation	-	-	-	-	-	-	-	-	-	-	-	-	NifU_N
HFD1_k127_2307064_0	745310.G432_01695	6.569e-210	673.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2K1PS@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
HFD1_k127_2307064_13	1123267.JONN01000001_gene1264	4.367e-60	213.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,2K4PP@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HFD1_k127_2307064_3	1123267.JONN01000001_gene1262	2.251e-177	574.0	2BWFC@1|root,33R2I@2|Bacteria,1R42X@1224|Proteobacteria,2U4BF@28211|Alphaproteobacteria,2K0XT@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2307064_6	1123267.JONN01000001_gene1261	1.875e-122	399.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,2K25K@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD1_k127_2307064_5	1123267.JONN01000001_gene1260	5.904e-150	479.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria,2K0BW@204457|Sphingomonadales	204457|Sphingomonadales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HFD1_k127_2307064_2	1123267.JONN01000002_gene189	2.544e-180	577.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,2K1IX@204457|Sphingomonadales	204457|Sphingomonadales	S	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M48
HFD1_k127_2307064_15	745310.G432_18285	2.136e-47	181.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria,2K0V6@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HFD1_k127_2307064_12	1346791.M529_13060	5.424e-66	238.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2K09E@204457|Sphingomonadales	204457|Sphingomonadales	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HFD1_k127_2307064_19	1449076.JOOE01000002_gene1014	1.017e-27	113.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,2K5VT@204457|Sphingomonadales	204457|Sphingomonadales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HFD1_k127_2307064_7	1123267.JONN01000002_gene194	1.624e-114	375.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria,2K16U@204457|Sphingomonadales	204457|Sphingomonadales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HFD1_k127_2307064_16	1449076.JOOE01000002_gene1012	8.597e-37	143.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,2K54Q@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1178
HFD1_k127_2307064_4	1081640.AGFU01000051_gene867	1.363e-170	543.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,2JZVM@204457|Sphingomonadales	204457|Sphingomonadales	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HFD1_k127_2307064_11	1449076.JOOE01000001_gene2261	5.478e-86	289.0	COG1392@1|root,COG1392@2|Bacteria,1QV5N@1224|Proteobacteria,2TWA9@28211|Alphaproteobacteria,2K1CT@204457|Sphingomonadales	204457|Sphingomonadales	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	NUDIX,PhoU_div
HFD1_k127_2307064_9	1123267.JONN01000002_gene196	2.855e-107	362.0	COG4529@1|root,COG4529@2|Bacteria,1MU3U@1224|Proteobacteria,2TUBM@28211|Alphaproteobacteria,2K079@204457|Sphingomonadales	204457|Sphingomonadales	S	FAD-NAD(P)-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_9
HFD1_k127_2307064_8	1502850.FG91_03608	2.405e-109	355.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,2K0QV@204457|Sphingomonadales	28211|Alphaproteobacteria	H	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HFD1_k127_2307064_14	1123267.JONN01000001_gene574	5.52e-52	187.0	COG1633@1|root,COG1633@2|Bacteria,1RJUG@1224|Proteobacteria,2UATR@28211|Alphaproteobacteria,2K5EA@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
HFD1_k127_2307064_10	1123267.JONN01000001_gene1971	4.025e-93	316.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,2K26X@204457|Sphingomonadales	204457|Sphingomonadales	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_2462523_2	1123267.JONN01000002_gene199	1.529e-165	531.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TRWS@28211|Alphaproteobacteria,2K02K@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD1_k127_2462523_4	194867.ALBQ01000027_gene2785	2.839e-128	416.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,2K15H@204457|Sphingomonadales	204457|Sphingomonadales	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HFD1_k127_2462523_5	1123267.JONN01000002_gene201	3.108e-122	395.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,2K1MK@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD1_k127_2462523_6	1144307.PMI04_00745	4.034e-121	402.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,2K56C@204457|Sphingomonadales	204457|Sphingomonadales	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HFD1_k127_2462523_0	1123267.JONN01000002_gene202	0.0	1079.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,2K1KK@204457|Sphingomonadales	204457|Sphingomonadales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HFD1_k127_2462523_3	1549858.MC45_10120	1.082e-146	473.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2K1EY@204457|Sphingomonadales	204457|Sphingomonadales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HFD1_k127_2462523_9	426355.Mrad2831_6244	1.203e-28	126.0	COG3279@1|root,COG4251@1|root,COG3279@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TWHG@28211|Alphaproteobacteria,1JSRP@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Phytochrome central region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HWE_HK,HisKA_3,PAS_2,PHY,Response_reg
HFD1_k127_2462523_1	1123267.JONN01000002_gene208	3.424e-230	718.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,2K0GV@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HFD1_k127_2462523_8	627192.SLG_08250	5.981e-30	128.0	COG5455@1|root,COG5455@2|Bacteria,1RJVB@1224|Proteobacteria,2U9H6@28211|Alphaproteobacteria,2K5B9@204457|Sphingomonadales	204457|Sphingomonadales	S	Nickel/cobalt transporter regulator	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
HFD1_k127_2462523_7	1123267.JONN01000002_gene212	2.969e-97	321.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,2K0WQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HFD1_k127_2466810_1	1449076.JOOE01000002_gene989	1.567e-257	811.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HFD1_k127_2466810_0	1449076.JOOE01000002_gene990	0.0	1637.0	COG0840@1|root,COG1511@1|root,COG3437@1|root,COG5002@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria,2KEIX@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Response_reg
HFD1_k127_2491494_4	1120705.FG95_02738	1.676e-59	212.0	COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria,2KCRH@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD1_k127_2491494_3	264198.Reut_B5659	2.522e-84	286.0	COG1011@1|root,COG1011@2|Bacteria,1NYX7@1224|Proteobacteria,2VTWY@28216|Betaproteobacteria,1K4HK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
HFD1_k127_2491494_5	685035.ADAE01000017_gene318	5.882e-51	183.0	COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,2U9AH@28211|Alphaproteobacteria,2K52N@204457|Sphingomonadales	204457|Sphingomonadales	J	Putative tRNA binding domain	csaA	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
HFD1_k127_2491494_0	745310.G432_16145	1.019e-119	394.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,2K0BU@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HFD1_k127_2491494_1	745310.G432_00115	3.301e-99	329.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria,2K0EP@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HFD1_k127_2491494_2	204669.Acid345_1475	1.191e-88	308.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria,2JJXH@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HFD1_k127_2491494_6	234267.Acid_0814	3.005e-23	102.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_2495103_2	1081640.AGFU01000071_gene3526	9.403e-46	170.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria,2K19S@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_2495103_0	1123267.JONN01000001_gene2422	1.002e-186	591.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2K0GT@204457|Sphingomonadales	204457|Sphingomonadales	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD1_k127_2495103_3	1123267.JONN01000001_gene2423	7.424e-23	100.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TUBY@28211|Alphaproteobacteria,2K1FB@204457|Sphingomonadales	204457|Sphingomonadales	EH	component I	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Anth_synt_I_N,Chorismate_bind
HFD1_k127_2495103_1	1123267.JONN01000001_gene2424	3.456e-105	345.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,2K25E@204457|Sphingomonadales	204457|Sphingomonadales	S	ICC-like phosphoesterases	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
HFD1_k127_2497710_8	1114964.L485_20970	4.404e-06	50.0	2CF7S@1|root,32S1E@2|Bacteria,1R918@1224|Proteobacteria,2U3VN@28211|Alphaproteobacteria,2K2C5@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2497710_6	1502851.FG93_05974	3.238e-32	128.0	COG3801@1|root,COG3801@2|Bacteria,1ND42@1224|Proteobacteria,2UGMC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD1_k127_2497710_2	1123267.JONN01000001_gene717	4.629e-173	553.0	2DBMQ@1|root,2Z9ZP@2|Bacteria,1QVZU@1224|Proteobacteria,2U5JS@28211|Alphaproteobacteria,2K406@204457|Sphingomonadales	204457|Sphingomonadales	S	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HFD1_k127_2497710_0	1449076.JOOE01000002_gene1052	5.85e-220	689.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2K1Z2@204457|Sphingomonadales	204457|Sphingomonadales	L	ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HFD1_k127_2497710_3	1545915.JROG01000004_gene2469	1.519e-54	201.0	COG1695@1|root,COG1695@2|Bacteria,1RHSE@1224|Proteobacteria,2U1HF@28211|Alphaproteobacteria,2K4SR@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HFD1_k127_2497710_1	1123267.JONN01000001_gene720	1.119e-178	569.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,2K14F@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HFD1_k127_2497710_4	1123267.JONN01000001_gene721	5.636e-48	177.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2UE8H@28211|Alphaproteobacteria,2K6DA@204457|Sphingomonadales	204457|Sphingomonadales	L	Uracil-DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
HFD1_k127_2497710_7	279238.Saro_3504	2.897e-06	49.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales	204457|Sphingomonadales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
HFD1_k127_2525027_21	1122603.ATVI01000006_gene825	1.218e-12	77.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1X5GK@135614|Xanthomonadales	135614|Xanthomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_2525027_6	1234595.C725_1251	5.066e-120	402.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2TZU7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_2525027_0	1234595.C725_1250	0.0	1523.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HFD1_k127_2525027_7	46429.BV95_03648	2e-101	339.0	COG0583@1|root,COG0583@2|Bacteria,1MWUD@1224|Proteobacteria,2U05D@28211|Alphaproteobacteria,2K11S@204457|Sphingomonadales	204457|Sphingomonadales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD1_k127_2525027_9	1470591.BW41_02504	1.507e-90	303.0	COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,2TRJM@28211|Alphaproteobacteria,2KCB3@204457|Sphingomonadales	204457|Sphingomonadales	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_2525027_13	414684.RC1_3079	7.58e-58	215.0	COG0697@1|root,COG0697@2|Bacteria,1P38S@1224|Proteobacteria,2U1BY@28211|Alphaproteobacteria,2JQWZ@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_2525027_23	392499.Swit_3968	6.582e-05	50.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PilZ
HFD1_k127_2525027_2	1537715.JQFJ01000002_gene1042	0.0	1166.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2K127@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
HFD1_k127_2525027_18	1123267.JONN01000002_gene285	1.099e-29	136.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1N7YB@1224|Proteobacteria,2V7CZ@28211|Alphaproteobacteria,2K2SU@204457|Sphingomonadales	204457|Sphingomonadales	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HFD1_k127_2525027_16	1187851.A33M_3863	1.373e-34	139.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_2525027_11	702113.PP1Y_Mpl7969	7.772e-67	233.0	COG4319@1|root,COG4319@2|Bacteria,1N361@1224|Proteobacteria,2UHUN@28211|Alphaproteobacteria,2KC0T@204457|Sphingomonadales	204457|Sphingomonadales	M	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_2525027_10	1123267.JONN01000001_gene2403	3.827e-72	252.0	COG2267@1|root,COG2267@2|Bacteria,1P7JV@1224|Proteobacteria,2TUWY@28211|Alphaproteobacteria,2K70A@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HFD1_k127_2525027_12	745310.G432_08690	2.738e-59	210.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2KCVI@204457|Sphingomonadales	204457|Sphingomonadales	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HFD1_k127_2525027_19	1120705.FG95_03728	2.148e-28	124.0	COG5455@1|root,COG5455@2|Bacteria,1MYUG@1224|Proteobacteria,2UBNQ@28211|Alphaproteobacteria,2KE3F@204457|Sphingomonadales	204457|Sphingomonadales	S	Nickel/cobalt transporter regulator	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
HFD1_k127_2525027_3	1123267.JONN01000001_gene2406	3.291e-298	925.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0GU@204457|Sphingomonadales	204457|Sphingomonadales	O	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD1_k127_2525027_22	693661.Arcve_0646	4.991e-12	72.0	arCOG06733@1|root,arCOG06733@2157|Archaea,2Y62E@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2525027_4	1090320.KB900605_gene1113	3.153e-253	793.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,2K1S0@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
HFD1_k127_2525027_1	1123267.JONN01000001_gene2414	0.0	1311.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria,2K15X@204457|Sphingomonadales	204457|Sphingomonadales	KL	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2
HFD1_k127_2525027_15	1346791.M529_07960	1.758e-46	173.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,2K4JB@204457|Sphingomonadales	204457|Sphingomonadales	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HFD1_k127_2525027_17	392499.Swit_3558	4.671e-33	132.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2U9A5@28211|Alphaproteobacteria,2K5Y3@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HFD1_k127_2525027_14	1123267.JONN01000001_gene2416	1.007e-46	170.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,2K62D@204457|Sphingomonadales	204457|Sphingomonadales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD1_k127_2525027_5	392499.Swit_3556	2.517e-161	512.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,2K1XQ@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HFD1_k127_2525027_8	1123267.JONN01000001_gene2418	3.717e-92	305.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,2K0QU@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HFD1_k127_2562104_0	1123267.JONN01000001_gene478	2.686e-216	680.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,2K0JK@204457|Sphingomonadales	204457|Sphingomonadales	E	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind
HFD1_k127_2562104_1	1081640.AGFU01000018_gene1773	1.08e-144	469.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,2K10F@204457|Sphingomonadales	204457|Sphingomonadales	E	Methionine synthase I (cobalamin-dependent), methyltransferase domain	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HFD1_k127_2562104_2	1123267.JONN01000001_gene476	2.347e-143	467.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2K03Q@204457|Sphingomonadales	204457|Sphingomonadales	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HFD1_k127_2562104_3	745310.G432_16545	1.347e-123	404.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2K0VB@204457|Sphingomonadales	204457|Sphingomonadales	K	ArsR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
HFD1_k127_2562104_4	1449076.JOOE01000003_gene3193	7.569e-55	193.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2K0H3@204457|Sphingomonadales	204457|Sphingomonadales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HFD1_k127_2562304_1	1123267.JONN01000001_gene462	6.41e-112	369.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,2K1TY@204457|Sphingomonadales	204457|Sphingomonadales	OU	signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HFD1_k127_2562304_3	685778.AORL01000018_gene26	1.358e-51	191.0	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2K490@204457|Sphingomonadales	204457|Sphingomonadales	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HFD1_k127_2562304_0	13689.BV96_01538	3.905e-244	761.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2K1EA@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD1_k127_2562304_2	1123267.JONN01000001_gene1671	1.734e-109	355.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,2K18R@204457|Sphingomonadales	204457|Sphingomonadales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_256703_0	1123267.JONN01000001_gene900	0.0	1028.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2K2JW@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HFD1_k127_256703_2	1123267.JONN01000001_gene897	5.644e-71	242.0	COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,2K4S3@204457|Sphingomonadales	204457|Sphingomonadales	F	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
HFD1_k127_256703_4	272568.GDI3052	8.399e-56	204.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U7R8@28211|Alphaproteobacteria,2JUQC@204441|Rhodospirillales	204441|Rhodospirillales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_256703_5	1146883.BLASA_1670	1.375e-36	141.0	COG0251@1|root,COG0251@2|Bacteria,2HPBY@201174|Actinobacteria,4EX1V@85013|Frankiales	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HFD1_k127_256703_3	500153.JOEK01000007_gene4465	6.469e-67	238.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria	201174|Actinobacteria	J	Phenazine biosynthesis protein PhzF	phzF	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HFD1_k127_256703_1	1030157.AFMP01000031_gene2940	1.581e-116	384.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,2K167@204457|Sphingomonadales	204457|Sphingomonadales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HFD1_k127_2581526_3	1123267.JONN01000001_gene630	1.129e-95	316.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,2K1HB@204457|Sphingomonadales	204457|Sphingomonadales	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HFD1_k127_2581526_1	1123267.JONN01000001_gene631	1.392e-124	407.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,2K01W@204457|Sphingomonadales	204457|Sphingomonadales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HFD1_k127_2581526_4	1123267.JONN01000001_gene632	1.572e-77	266.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,2K1G1@204457|Sphingomonadales	204457|Sphingomonadales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HFD1_k127_2581526_2	1123267.JONN01000001_gene633	1.244e-102	341.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2K1QM@204457|Sphingomonadales	204457|Sphingomonadales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HFD1_k127_2581526_0	1123269.NX02_13330	3.593e-201	637.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,2K0KU@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the GPI family	pgi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HFD1_k127_2581526_5	452662.SJA_C1-18610	1.956e-15	77.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,2K11W@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HFD1_k127_2622710_0	1030157.AFMP01000031_gene2940	9.962e-224	699.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,2K167@204457|Sphingomonadales	204457|Sphingomonadales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HFD1_k127_2622710_1	1030157.AFMP01000031_gene2941	2.118e-78	273.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2JZYK@204457|Sphingomonadales	204457|Sphingomonadales	FP	exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HFD1_k127_2638663_1	1183438.GKIL_2082	5.589e-219	694.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1GDGA@1117|Cyanobacteria	1117|Cyanobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_2638663_3	13689.BV96_03120	1.337e-104	344.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,2K8RV@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HFD1_k127_2638663_7	1123267.JONN01000001_gene1345	1.708e-59	215.0	COG0739@1|root,COG0739@2|Bacteria,1RK7E@1224|Proteobacteria,2UB7B@28211|Alphaproteobacteria,2K58B@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HFD1_k127_2638663_6	627192.SLG_23250	6.898e-100	334.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,2K0HQ@204457|Sphingomonadales	204457|Sphingomonadales	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HFD1_k127_2638663_2	1123267.JONN01000001_gene1343	6.132e-140	447.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,2K0TX@204457|Sphingomonadales	204457|Sphingomonadales	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HFD1_k127_2638663_10	1121123.AUAO01000002_gene450	6.072e-13	79.0	COG3391@1|root,COG3391@2|Bacteria,1NC58@1224|Proteobacteria,2UFDR@28211|Alphaproteobacteria,2KH9D@204458|Caulobacterales	204458|Caulobacterales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HFD1_k127_2638663_8	1120705.FG95_00590	8.533e-56	202.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2U72Q@28211|Alphaproteobacteria,2K4KM@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HFD1_k127_2638663_4	1123267.JONN01000001_gene1341	2.257e-103	342.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,2K0KE@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HFD1_k127_2638663_5	1123267.JONN01000001_gene1340	7.492e-103	341.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,2K0IR@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HFD1_k127_2638663_0	1123267.JONN01000001_gene1339	3.244e-229	716.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,2K0QX@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HFD1_k127_2638663_9	1123269.NX02_23780	1.542e-38	153.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,2K18U@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH dehydrogenase	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HFD1_k127_2642727_2	290397.Adeh_1021	4.739e-49	192.0	COG3239@1|root,COG3239@2|Bacteria,1PP7Y@1224|Proteobacteria,43525@68525|delta/epsilon subdivisions,2X94I@28221|Deltaproteobacteria,2Z1VN@29|Myxococcales	28221|Deltaproteobacteria	I	fatty acid desaturase	-	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HFD1_k127_2642727_0	745310.G432_10805	9.273e-244	766.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2K1RR@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HFD1_k127_2642727_1	1123267.JONN01000001_gene582	1.338e-168	537.0	COG0773@1|root,COG0773@2|Bacteria,1MVCG@1224|Proteobacteria,2TTDN@28211|Alphaproteobacteria,2K0S4@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-N-acetylmuramate-alanine ligase	-	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_2642785_6	1123267.JONN01000002_gene106	7.68e-121	395.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TU4E@28211|Alphaproteobacteria,2K07U@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HFD1_k127_2642785_4	1123267.JONN01000002_gene109	1.651e-151	481.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,2K0D0@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HFD1_k127_2642785_11	1502850.FG91_02374	3.206e-33	130.0	COG2329@1|root,COG2329@2|Bacteria,1RHK9@1224|Proteobacteria,2TZMK@28211|Alphaproteobacteria,2K7VE@204457|Sphingomonadales	204457|Sphingomonadales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2642785_0	1123267.JONN01000002_gene21	0.0	1196.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,2K0DV@204457|Sphingomonadales	204457|Sphingomonadales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
HFD1_k127_2642785_8	1248917.ANFX01000032_gene904	4.615e-74	259.0	COG1266@1|root,COG1266@2|Bacteria,1RJQW@1224|Proteobacteria,2UB06@28211|Alphaproteobacteria,2K5HR@204457|Sphingomonadales	204457|Sphingomonadales	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HFD1_k127_2642785_5	1192759.AKIB01000011_gene2690	1.677e-133	434.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,2K165@204457|Sphingomonadales	204457|Sphingomonadales	FL	Metal binding domain of Ada	ada	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HFD1_k127_2642785_10	1123267.JONN01000002_gene15	1.305e-47	178.0	2CVTP@1|root,32SY9@2|Bacteria,1N209@1224|Proteobacteria,2UC8J@28211|Alphaproteobacteria,2K6M8@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
HFD1_k127_2642785_13	1453501.JELR01000001_gene3222	7.211e-25	113.0	COG0454@1|root,COG0454@2|Bacteria,1QUHE@1224|Proteobacteria,1T1Z5@1236|Gammaproteobacteria,46D90@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	ysnE	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HFD1_k127_2642785_14	1112212.JH584235_gene813	6.335e-12	66.0	COG0454@1|root,COG0454@2|Bacteria,1QUHE@1224|Proteobacteria,2TWXT@28211|Alphaproteobacteria,2KEFM@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HFD1_k127_2642785_9	1123267.JONN01000002_gene11	6.849e-70	244.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2U5IC@28211|Alphaproteobacteria,2K4UU@204457|Sphingomonadales	204457|Sphingomonadales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HFD1_k127_2642785_1	1123267.JONN01000002_gene10	8.132e-289	891.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,2K08A@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HFD1_k127_2642785_7	1123267.JONN01000002_gene9	5.694e-115	377.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,2K0A5@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HFD1_k127_2642785_2	1123267.JONN01000002_gene8	6.121e-277	857.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2K03H@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HFD1_k127_2642785_12	1549858.MC45_10245	4.66e-30	120.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2UBXX@28211|Alphaproteobacteria,2K5WN@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02113,ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
HFD1_k127_2642785_3	1123267.JONN01000002_gene5	8.187e-251	781.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,2K008@204457|Sphingomonadales	204457|Sphingomonadales	U	Flp pilus assembly protein, ATPase CpaF	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HFD1_k127_2652818_8	1163409.UUA_00430	1.167e-76	263.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RMUK@1236|Gammaproteobacteria,1XC6P@135614|Xanthomonadales	135614|Xanthomonadales	P	LacY proton/sugar symporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HFD1_k127_2652818_12	1411123.JQNH01000001_gene561	1.77e-27	121.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,2UEEU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD1_k127_2652818_6	1522072.IL54_1595	1.495e-135	442.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2K041@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HFD1_k127_2652818_3	1121033.AUCF01000026_gene2971	1.601e-154	501.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2TRKT@28211|Alphaproteobacteria,2JQTN@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD1_k127_2652818_0	1449076.JOOE01000001_gene2158	0.0	1147.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2K0F8@204457|Sphingomonadales	28211|Alphaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HFD1_k127_2652818_4	13689.BV96_04645	1.545e-152	494.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,2K1GY@204457|Sphingomonadales	204457|Sphingomonadales	P	NnrS protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrS
HFD1_k127_2652818_5	1207055.C100_03435	2.618e-137	447.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K0ZS@204457|Sphingomonadales	204457|Sphingomonadales	T	nitrogen fixation sensor protein fixL	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9
HFD1_k127_2652818_7	1123269.NX02_09275	1.417e-82	280.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,2K16W@204457|Sphingomonadales	204457|Sphingomonadales	K	part of global network that controls expression of aerobic respiratory terminal oxidases and carbon and nitrogen metabolic enzymes	-	-	-	ko:K14987	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HFD1_k127_2652818_16	1123267.JONN01000001_gene2192	0.0004584	47.0	2AGW3@1|root,3174G@2|Bacteria,1NJ32@1224|Proteobacteria,2UN3I@28211|Alphaproteobacteria,2K7BC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2652818_15	1121937.AUHJ01000019_gene1298	0.0001648	50.0	2EG3R@1|root,339VS@2|Bacteria,1NQDY@1224|Proteobacteria,1SI0X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2652818_11	1030157.AFMP01000032_gene434	6.074e-29	130.0	COG3629@1|root,COG3629@2|Bacteria,1NCCW@1224|Proteobacteria,2UGC8@28211|Alphaproteobacteria,2K3I7@204457|Sphingomonadales	204457|Sphingomonadales	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
HFD1_k127_2652818_13	652103.Rpdx1_0816	1.094e-16	93.0	COG2199@1|root,COG2202@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,1P3YR@1224|Proteobacteria,2TZ5R@28211|Alphaproteobacteria,3JYEG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_3
HFD1_k127_2652818_14	190650.CC_2380	2.219e-05	50.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HFD1_k127_2652818_9	1123267.JONN01000001_gene837	1.335e-59	213.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2U704@28211|Alphaproteobacteria,2K2P0@204457|Sphingomonadales	204457|Sphingomonadales	O	protein-L-isoaspartate	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HFD1_k127_2652818_2	1123267.JONN01000001_gene838	2.045e-178	576.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,2JZY5@204457|Sphingomonadales	204457|Sphingomonadales	MU	membrane	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HFD1_k127_2652818_10	1123267.JONN01000001_gene839	4.671e-33	132.0	COG3827@1|root,COG3827@2|Bacteria,1MX61@1224|Proteobacteria,2TSG8@28211|Alphaproteobacteria,2K7EP@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09991	-	-	-	-	ko00000	-	-	-	DUF2497
HFD1_k127_2652818_1	1123267.JONN01000001_gene840	3.123e-306	948.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria,2K16Q@204457|Sphingomonadales	204457|Sphingomonadales	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_2662317_2	1382230.ASAP_0659	2.357e-55	198.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2TRCK@28211|Alphaproteobacteria,2JPFE@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HFD1_k127_2662317_4	1123267.JONN01000001_gene2183	3.55e-33	135.0	COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria,2K56H@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
HFD1_k127_2662317_6	1537715.JQFJ01000002_gene1612	2.806e-07	56.0	2AG1F@1|root,3165I@2|Bacteria,1NGEF@1224|Proteobacteria,2UMPX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HFD1_k127_2662317_3	392499.Swit_1919	8.898e-55	197.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,2K570@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
HFD1_k127_2662317_0	745310.G432_11280	2.131e-237	741.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JZY8@204457|Sphingomonadales	204457|Sphingomonadales	S	peptidase U62, modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD1_k127_2662317_5	1550073.JROH01000001_gene542	2.511e-22	99.0	COG4391@1|root,COG4391@2|Bacteria,1N7F4@1224|Proteobacteria,2UHY4@28211|Alphaproteobacteria,2K6U4@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
HFD1_k127_2662317_1	1123267.JONN01000001_gene2188	9.883e-146	469.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria,2K06G@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_2663887_0	1123267.JONN01000002_gene94	6.067e-114	372.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria,2K1JS@204457|Sphingomonadales	204457|Sphingomonadales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HFD1_k127_2663887_1	1123267.JONN01000001_gene1172	8.325e-91	304.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2K0CZ@204457|Sphingomonadales	204457|Sphingomonadales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HFD1_k127_2663887_4	1123267.JONN01000001_gene1170	1.109e-39	157.0	COG0745@1|root,COG0745@2|Bacteria	1123267.JONN01000001_gene1170|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2663887_3	1123267.JONN01000001_gene1169	2.989e-43	164.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TW2U@28211|Alphaproteobacteria,2KE9I@204457|Sphingomonadales	204457|Sphingomonadales	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,EAL
HFD1_k127_2681255_5	685035.ADAE01000002_gene2684	3.042e-58	218.0	2ASJY@1|root,31I0J@2|Bacteria,1N0AE@1224|Proteobacteria,2UCJQ@28211|Alphaproteobacteria,2K162@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2681255_7	1470591.BW41_03913	6.217e-37	148.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2UB7Z@28211|Alphaproteobacteria,2K4SW@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HFD1_k127_2681255_3	1346791.M529_04345	2.482e-72	252.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria,2K3YM@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HFD1_k127_2681255_2	1123267.JONN01000001_gene954	3.602e-124	404.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,2K09B@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HFD1_k127_2681255_1	1123267.JONN01000001_gene953	7.46e-210	671.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,2K0PK@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HFD1_k127_2681255_4	1123267.JONN01000001_gene952	3.964e-71	243.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2U75V@28211|Alphaproteobacteria,2K3X2@204457|Sphingomonadales	204457|Sphingomonadales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HFD1_k127_2681255_6	745310.G432_18010	5.453e-49	183.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2K0KF@204457|Sphingomonadales	204457|Sphingomonadales	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	-	-	-	-	-	-	-	-	-	-	PPK2
HFD1_k127_2681255_0	1123267.JONN01000001_gene948	4.34e-280	865.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,2K0PT@204457|Sphingomonadales	204457|Sphingomonadales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD1_k127_2700889_1	1449076.JOOE01000001_gene1987	3.306e-306	950.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K02W@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidase M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
HFD1_k127_2700889_2	1123269.NX02_06855	2.286e-268	847.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K0WG@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,Response_reg
HFD1_k127_2700889_8	1123267.JONN01000001_gene881	1.434e-42	158.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria,2UF5P@28211|Alphaproteobacteria,2K639@204457|Sphingomonadales	204457|Sphingomonadales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_2700889_6	420324.KI911956_gene3445	1.34e-61	225.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria	1224|Proteobacteria	S	COG1073 hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
HFD1_k127_2700889_3	1123267.JONN01000002_gene308	1.881e-250	776.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,2JZWY@204457|Sphingomonadales	204457|Sphingomonadales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HFD1_k127_2700889_4	1346791.M529_10865	2.627e-103	352.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K19X@204457|Sphingomonadales	204457|Sphingomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HFD1_k127_2700889_0	1123267.JONN01000001_gene1128	0.0	1321.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2K15B@204457|Sphingomonadales	204457|Sphingomonadales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HFD1_k127_2700889_9	1081640.AGFU01000005_gene1089	1.552e-35	137.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,2K5WD@204457|Sphingomonadales	204457|Sphingomonadales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HFD1_k127_2700889_5	1123267.JONN01000001_gene1130	1.95e-90	305.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_2700889_7	1219035.NT2_04_01970	7.892e-51	184.0	COG0537@1|root,COG0537@2|Bacteria,1N49J@1224|Proteobacteria,2U85A@28211|Alphaproteobacteria,2K4UB@204457|Sphingomonadales	204457|Sphingomonadales	FG	Histidine triad (HIT) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HFD1_k127_271110_12	1280949.HAD_15307	1.051e-47	172.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase domain protein	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD1_k127_271110_3	1449076.JOOE01000001_gene2245	1.356e-118	397.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K2WX@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HFD1_k127_271110_1	627192.SLG_33510	3.169e-220	697.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSQN@28211|Alphaproteobacteria,2KCC8@204457|Sphingomonadales	204457|Sphingomonadales	C	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD1_k127_271110_15	1123267.JONN01000001_gene1800	1.057e-30	125.0	2BJB4@1|root,3186Q@2|Bacteria,1NG3X@1224|Proteobacteria,2UG56@28211|Alphaproteobacteria,2K6GS@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_271110_9	1123267.JONN01000001_gene1801	1.413e-66	236.0	COG2941@1|root,COG2941@2|Bacteria,1RAK4@1224|Proteobacteria,2U85I@28211|Alphaproteobacteria,2K46W@204457|Sphingomonadales	204457|Sphingomonadales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
HFD1_k127_271110_14	1522072.IL54_2616	1.499e-44	168.0	COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,2K59V@204457|Sphingomonadales	204457|Sphingomonadales	O	Disulfide bond formation protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbB
HFD1_k127_271110_2	1123267.JONN01000001_gene1803	3.831e-214	672.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,2K0TK@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HFD1_k127_271110_13	1112212.JH584235_gene2841	2.45e-46	182.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,2K22Y@204457|Sphingomonadales	204457|Sphingomonadales	D	Membrane-bound metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD1_k127_271110_10	1112212.JH584235_gene2840	2.752e-60	211.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria,2K4F0@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HFD1_k127_271110_4	1123267.JONN01000001_gene1812	2.233e-101	337.0	COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,2UBDH@28211|Alphaproteobacteria,2K2BR@204457|Sphingomonadales	204457|Sphingomonadales	V	beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,Peptidase_S13
HFD1_k127_271110_11	1123267.JONN01000001_gene1806	7.343e-50	184.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,2K55D@204457|Sphingomonadales	204457|Sphingomonadales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HFD1_k127_271110_6	1112216.JH594425_gene482	1.775e-81	276.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,2K3WB@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD1_k127_271110_5	1122612.AUBA01000008_gene2217	6.714e-90	308.0	COG1566@1|root,COG1566@2|Bacteria,1R50C@1224|Proteobacteria,2TUCN@28211|Alphaproteobacteria,2K0QD@204457|Sphingomonadales	204457|Sphingomonadales	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
HFD1_k127_271110_0	1123267.JONN01000001_gene1811	0.0	1083.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,2K1U5@204457|Sphingomonadales	204457|Sphingomonadales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HFD1_k127_271110_7	555793.WSK_0706	5.738e-80	278.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria,2K3YA@204457|Sphingomonadales	204457|Sphingomonadales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
HFD1_k127_271110_8	1123267.JONN01000001_gene1814	2.509e-77	274.0	COG1729@1|root,COG1729@2|Bacteria,1R8C4@1224|Proteobacteria,2VBNQ@28211|Alphaproteobacteria,2K0FK@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HFD1_k127_271797_5	629773.AORY01000004_gene596	4.935e-45	164.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,2K0YM@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HFD1_k127_271797_1	1123267.JONN01000001_gene1703	4.656e-108	360.0	COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2TXS0@28211|Alphaproteobacteria,2K90M@204457|Sphingomonadales	204457|Sphingomonadales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HFD1_k127_271797_3	1123267.JONN01000001_gene1622	2.948e-82	276.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,2K3XB@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HFD1_k127_271797_4	1123267.JONN01000001_gene1623	8.017e-57	201.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2K4H8@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HFD1_k127_271797_2	194867.ALBQ01000004_gene3598	3.27e-85	291.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2TT0S@28211|Alphaproteobacteria,2K14Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD1_k127_271797_0	1123267.JONN01000001_gene1626	2.865e-251	784.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JZWE@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HFD1_k127_278471_6	1123267.JONN01000001_gene1648	3.986e-88	298.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,2U2M4@28211|Alphaproteobacteria,2K040@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HFD1_k127_278471_5	1335760.ASTG01000005_gene991	2.043e-113	376.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2K18T@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_278471_9	1030157.AFMP01000031_gene2895	1.821e-51	192.0	2BX8M@1|root,31H0R@2|Bacteria,1MYMI@1224|Proteobacteria,2UB1B@28211|Alphaproteobacteria,2K27Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
HFD1_k127_278471_1	1123267.JONN01000001_gene1653	3.72e-197	617.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,2K13Q@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HFD1_k127_278471_2	1449076.JOOE01000001_gene2089	6.326e-140	453.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,2K29S@204457|Sphingomonadales	204457|Sphingomonadales	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HFD1_k127_278471_7	392499.Swit_3851	4.903e-57	203.0	2DMJE@1|root,32RYR@2|Bacteria,1N7PS@1224|Proteobacteria,2UFEW@28211|Alphaproteobacteria,2K57K@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
HFD1_k127_278471_3	1123267.JONN01000001_gene1578	7.198e-135	445.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TWWQ@28211|Alphaproteobacteria,2KEK8@204457|Sphingomonadales	204457|Sphingomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HFD1_k127_278471_0	1123267.JONN01000001_gene1579	1.151e-278	870.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,2K0XK@204457|Sphingomonadales	204457|Sphingomonadales	M	Penicillin-binding Protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HFD1_k127_278471_10	1123267.JONN01000001_gene1583	1.748e-31	134.0	COG4530@1|root,COG4530@2|Bacteria,1N42Z@1224|Proteobacteria,2UDI6@28211|Alphaproteobacteria,2K62H@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (FYDLN_acid)	-	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
HFD1_k127_278471_4	1090319.KE386571_gene2809	2.046e-124	407.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2TVXS@28211|Alphaproteobacteria,2KEPE@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	3.5.1.101	ko:K18457	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HFD1_k127_278471_8	1123267.JONN01000001_gene1584	2.104e-56	203.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,2K3ZM@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HFD1_k127_2838025_0	1123267.JONN01000001_gene2385	0.0	1109.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2K0CP@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HFD1_k127_2838025_5	1335760.ASTG01000006_gene1343	1.925e-21	96.0	2EFVT@1|root,339N0@2|Bacteria,1NJX8@1224|Proteobacteria,2UJ01@28211|Alphaproteobacteria,2K78R@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2838025_3	1144307.PMI04_02379	2.662e-93	311.0	COG1878@1|root,COG1878@2|Bacteria,1R8IH@1224|Proteobacteria,2U9RH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HFD1_k127_2838025_2	1123267.JONN01000001_gene2387	1.098e-108	355.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria,2K18B@204457|Sphingomonadales	204457|Sphingomonadales	S	Aminomethyltransferase	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
HFD1_k127_2838025_1	1123267.JONN01000001_gene2388	2.473e-159	508.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2TT2U@28211|Alphaproteobacteria,2K057@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HFD1_k127_2838025_4	1123267.JONN01000001_gene2389	3.793e-78	266.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2TQXG@28211|Alphaproteobacteria,2K1GD@204457|Sphingomonadales	204457|Sphingomonadales	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
HFD1_k127_2838215_6	194867.ALBQ01000023_gene3204	2.752e-64	222.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,2K0PT@204457|Sphingomonadales	204457|Sphingomonadales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HFD1_k127_2838215_0	1123267.JONN01000001_gene947	1.228e-207	652.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,2K0ID@204457|Sphingomonadales	204457|Sphingomonadales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HFD1_k127_2838215_8	279238.Saro_0857	9.955e-13	72.0	2DR05@1|root,339MI@2|Bacteria,1NHD4@1224|Proteobacteria,2VBVW@28211|Alphaproteobacteria,2K749@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase inhibitor I78 family	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I78
HFD1_k127_2838215_4	1123267.JONN01000001_gene943	2.245e-85	289.0	COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,2K4AT@204457|Sphingomonadales	204457|Sphingomonadales	L	ATPase involved in DNA replication	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA
HFD1_k127_2838215_3	1123267.JONN01000001_gene942	2.458e-114	383.0	COG3249@1|root,COG3249@2|Bacteria,1R81G@1224|Proteobacteria,2U1EP@28211|Alphaproteobacteria,2K0TT@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2838215_2	1219049.SP5_001_00390	4.905e-161	514.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,2K07H@204457|Sphingomonadales	204457|Sphingomonadales	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD1_k127_2838215_5	1112212.JH584235_gene534	1.418e-69	244.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,2K28Q@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
HFD1_k127_2838215_7	1449076.JOOE01000001_gene1820	1.902e-43	161.0	COG3801@1|root,COG3801@2|Bacteria,1PTCF@1224|Proteobacteria,2V58I@28211|Alphaproteobacteria,2K60B@204457|Sphingomonadales	204457|Sphingomonadales	S	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HFD1_k127_2838215_9	1219049.SP5_001_00420	7.841e-09	66.0	2FBT4@1|root,343XW@2|Bacteria,1NV0Z@1224|Proteobacteria,2URIG@28211|Alphaproteobacteria,2K4MR@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2838215_1	1537715.JQFJ01000002_gene1070	8.152e-165	528.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria,2K25Z@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HFD1_k127_2869246_0	1123267.JONN01000001_gene662	0.0	1056.0	COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U1V9@28211|Alphaproteobacteria,2KEE4@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_2869246_2	1123267.JONN01000001_gene661	5.41e-161	519.0	COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,2U3N5@28211|Alphaproteobacteria,2K4RF@204457|Sphingomonadales	204457|Sphingomonadales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD1_k127_2869246_10	1449076.JOOE01000004_gene400	5.809e-60	213.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,2K3XC@204457|Sphingomonadales	204457|Sphingomonadales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HFD1_k127_2869246_4	1123267.JONN01000001_gene659	1.213e-146	471.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,2K03N@204457|Sphingomonadales	204457|Sphingomonadales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HFD1_k127_2869246_6	46429.BV95_03864	2.126e-116	384.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria,2K0PW@204457|Sphingomonadales	204457|Sphingomonadales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HFD1_k127_2869246_8	1123267.JONN01000001_gene657	7.109e-78	268.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,2K1NS@204457|Sphingomonadales	204457|Sphingomonadales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HFD1_k127_2869246_1	1123267.JONN01000001_gene656	3.526e-180	571.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,2K09I@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HFD1_k127_2869246_7	1123267.JONN01000001_gene653	5.383e-103	345.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria,2K0AW@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HFD1_k127_2869246_11	1030157.AFMP01000044_gene1932	5.41e-41	157.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2UFTM@28211|Alphaproteobacteria,2K62R@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HFD1_k127_2869246_3	1081640.AGFU01000018_gene1794	3.383e-159	506.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2K0JQ@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HFD1_k127_2869246_5	1123267.JONN01000001_gene648	1.488e-121	396.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2TS7W@28211|Alphaproteobacteria,2K1R3@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	xerC_2	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HFD1_k127_2869246_9	1030157.AFMP01000044_gene1928	6.096e-62	220.0	COG3159@1|root,COG3159@2|Bacteria,1Q6ZX@1224|Proteobacteria,2VD3T@28211|Alphaproteobacteria,2K427@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
HFD1_k127_2869246_12	1101190.ARWB01000001_gene1782	3.328e-32	134.0	COG2091@1|root,COG2091@2|Bacteria,1NPFV@1224|Proteobacteria,2U4XS@28211|Alphaproteobacteria,36YGQ@31993|Methylocystaceae	28211|Alphaproteobacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2881756_1	1030157.AFMP01000043_gene1697	5.036e-82	278.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,2K0QU@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HFD1_k127_2881756_3	1123267.JONN01000001_gene2419	5.864e-30	119.0	COG0333@1|root,COG0333@2|Bacteria,1PU3Y@1224|Proteobacteria,2UF54@28211|Alphaproteobacteria,2K6RY@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HFD1_k127_2881756_2	383381.EH30_08470	5.369e-32	131.0	COG3788@1|root,COG3788@2|Bacteria,1N0G5@1224|Proteobacteria,2UDEJ@28211|Alphaproteobacteria,2K642@204457|Sphingomonadales	204457|Sphingomonadales	S	relative of glutathione S-transferase, MAPEG superfamily	-	-	-	ko:K07136	-	-	-	-	ko00000	-	-	-	MAPEG
HFD1_k127_2881756_0	46429.BV95_02761	5.777e-88	291.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria,2K19S@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_2917846_1	1123267.JONN01000002_gene287	6.504e-78	284.0	COG0758@1|root,COG0758@2|Bacteria,1R9P1@1224|Proteobacteria,2U30Q@28211|Alphaproteobacteria,2K3JF@204457|Sphingomonadales	204457|Sphingomonadales	LU	DNA mediated transformation	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_2917846_0	1123267.JONN01000001_gene2258	1.951e-103	345.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,2TU8K@28211|Alphaproteobacteria,2K0JU@204457|Sphingomonadales	204457|Sphingomonadales	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HFD1_k127_2917846_2	1123267.JONN01000001_gene2247	2.768e-53	190.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,2K1NQ@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HFD1_k127_2966475_0	1123267.JONN01000001_gene1785	4.424e-306	949.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	-	-	-	-	-	-	-	-	-	-	-	-	K_trans
HFD1_k127_2966475_1	1219045.BV98_002583	1.897e-97	338.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2TSS7@28211|Alphaproteobacteria,2K2BZ@204457|Sphingomonadales	204457|Sphingomonadales	KT	Domain of unknown function (DUF4118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,Trans_reg_C
HFD1_k127_3159087_5	1123267.JONN01000001_gene1321	2.59e-86	293.0	COG1511@1|root,COG1511@2|Bacteria,1QVM2@1224|Proteobacteria,2TWI1@28211|Alphaproteobacteria,2KEGK@204457|Sphingomonadales	204457|Sphingomonadales	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3159087_9	1123267.JONN01000001_gene1322	3.529e-26	109.0	COG5454@1|root,COG5454@2|Bacteria,1N8U9@1224|Proteobacteria,2UGCD@28211|Alphaproteobacteria,2K711@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1467
HFD1_k127_3159087_1	1123267.JONN01000001_gene1323	2.164e-240	754.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,2K04C@204457|Sphingomonadales	204457|Sphingomonadales	S	metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HFD1_k127_3159087_4	1123267.JONN01000001_gene1324	6.731e-128	412.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2TS5A@28211|Alphaproteobacteria,2K0SW@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HFD1_k127_3159087_6	1044.EH31_02285	1.327e-55	214.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,2JZZZ@204457|Sphingomonadales	204457|Sphingomonadales	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,BPL_LplA_LipB_2
HFD1_k127_3159087_3	1123267.JONN01000001_gene1326	9.827e-200	632.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,2K08E@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HFD1_k127_3159087_2	745310.G432_00225	2.564e-232	730.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,2K0EQ@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HFD1_k127_3159087_0	1123267.JONN01000001_gene1328	0.0	1065.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2K1DM@204457|Sphingomonadales	204457|Sphingomonadales	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
HFD1_k127_3159087_8	627192.SLG_23080	1.916e-39	156.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,2K53D@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HFD1_k127_3159087_7	1123267.JONN01000001_gene1330	1.847e-48	177.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,2JZZS@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD1_k127_3165001_1	1123267.JONN01000001_gene1054	6.023e-153	489.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,2K04R@204457|Sphingomonadales	204457|Sphingomonadales	S	Phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HFD1_k127_3165001_2	1123267.JONN01000001_gene1055	4.006e-119	388.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,2K1HH@204457|Sphingomonadales	204457|Sphingomonadales	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,NTP_transferase
HFD1_k127_3165001_0	1123267.JONN01000001_gene1056	2.28e-249	789.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,2K06P@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
HFD1_k127_3247475_5	234267.Acid_2317	2.023e-29	123.0	COG1171@1|root,COG1171@2|Bacteria,3Y2RI@57723|Acidobacteria	57723|Acidobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HFD1_k127_3247475_0	1123267.JONN01000002_gene222	0.0	1086.0	COG1012@1|root,COG2030@1|root,COG1012@2|Bacteria,COG2030@2|Bacteria,1MWD4@1224|Proteobacteria,2TUPI@28211|Alphaproteobacteria,2K1V8@204457|Sphingomonadales	204457|Sphingomonadales	CI	MaoC like domain	-	-	1.2.1.91,3.3.2.12	ko:K02618	ko00360,ko01120,map00360,map01120	-	R09820,R09836	RC00080,RC02667	ko00000,ko00001,ko01000	-	-	-	Aldedh,MaoC_dehydratas
HFD1_k127_3247475_3	420324.KI911965_gene1297	3.289e-40	154.0	COG0517@1|root,COG0517@2|Bacteria,1NMH1@1224|Proteobacteria,2U9D8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HFD1_k127_3247475_2	1123267.JONN01000002_gene221	2.674e-43	164.0	COG0711@1|root,COG0711@2|Bacteria,1N0P5@1224|Proteobacteria,2U5DD@28211|Alphaproteobacteria,2K57Z@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF_2	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD1_k127_3247475_4	1123269.NX02_00320	4.305e-35	139.0	COG0711@1|root,COG0711@2|Bacteria,1MZGU@1224|Proteobacteria,2UBVW@28211|Alphaproteobacteria,2K5D0@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF_1	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HFD1_k127_3247475_6	685778.AORL01000015_gene2360	3.852e-25	111.0	COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UFPN@28211|Alphaproteobacteria,2K61N@204457|Sphingomonadales	204457|Sphingomonadales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HFD1_k127_3247475_1	629773.AORY01000004_gene399	8.034e-82	278.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,2K17B@204457|Sphingomonadales	204457|Sphingomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HFD1_k127_3250482_7	685778.AORL01000023_gene2152	1.049e-10	64.0	2E9WT@1|root,33CDQ@2|Bacteria,1NDWW@1224|Proteobacteria,2UH4W@28211|Alphaproteobacteria,2K6WY@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_gran_rgn
HFD1_k127_3250482_1	1123267.JONN01000001_gene1978	4.915e-182	579.0	COG0493@1|root,COG0493@2|Bacteria,1P58U@1224|Proteobacteria,2TUCG@28211|Alphaproteobacteria,2K06F@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Pyr_redox_2
HFD1_k127_3250482_2	13689.BV96_00109	2.156e-158	509.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,2K18M@204457|Sphingomonadales	204457|Sphingomonadales	C	Dehydrogenase	lldD	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HFD1_k127_3250482_6	682795.AciX8_0980	5.693e-37	145.0	COG2128@1|root,COG2128@2|Bacteria,3Y4TK@57723|Acidobacteria,2JJJ6@204432|Acidobacteriia	204432|Acidobacteriia	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HFD1_k127_3250482_3	1123267.JONN01000001_gene1859	1.126e-140	452.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2K1HY@204457|Sphingomonadales	204457|Sphingomonadales	G	Aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HFD1_k127_3250482_4	1123267.JONN01000001_gene1860	6.704e-78	269.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2U5B6@28211|Alphaproteobacteria,2K49D@204457|Sphingomonadales	204457|Sphingomonadales	O	maleylacetoacetate isomerase	-	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C_2,GST_N,GST_N_3
HFD1_k127_3250482_5	745310.G432_14465	6.52e-52	188.0	COG0824@1|root,COG0824@2|Bacteria,1N06V@1224|Proteobacteria,2UCAQ@28211|Alphaproteobacteria,2K5A4@204457|Sphingomonadales	204457|Sphingomonadales	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
HFD1_k127_3250482_0	1123267.JONN01000001_gene1863	0.0	1015.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,2K19E@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase S9	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD1_k127_3255794_2	1121129.KB903364_gene2954	5.835e-14	79.0	2AHEJ@1|root,317RR@2|Bacteria,4P93N@976|Bacteroidetes,2FZC5@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3255794_0	75379.Tint_0881	8.05e-227	716.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,1KJ6Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HFD1_k127_3255794_1	1266925.JHVX01000009_gene74	9.921e-19	88.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VSRT@28216|Betaproteobacteria,37338@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HFD1_k127_3278851_2	1123267.JONN01000001_gene2129	6.857e-71	244.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,2K0R3@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HFD1_k127_3278851_0	1123267.JONN01000001_gene2128	7.394e-167	528.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,2K0MQ@204457|Sphingomonadales	204457|Sphingomonadales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HFD1_k127_3278851_5	1248916.ANFY01000010_gene419	2.583e-55	196.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria,2UCCW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
HFD1_k127_3278851_3	1123267.JONN01000001_gene2105	2.353e-63	229.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria,2K4MT@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_3278851_6	1123267.JONN01000001_gene2106	1.721e-35	135.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2UF6K@28211|Alphaproteobacteria,2K5YR@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HFD1_k127_3278851_4	1123269.NX02_24590	7.44e-60	208.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,2K4FX@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HFD1_k127_3278851_1	1187851.A33M_2064	2.385e-80	280.0	COG3693@1|root,COG3693@2|Bacteria,1P7A6@1224|Proteobacteria,2TT8P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Domain of unknown function (DUF4424)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4424
HFD1_k127_3308041_0	640081.Dsui_0924	2.489e-197	626.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VNTF@28216|Betaproteobacteria,2KVB8@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HFD1_k127_3308041_1	1304878.AUGD01000006_gene6738	1.003e-29	121.0	COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,2UFJA@28211|Alphaproteobacteria,3K5JZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HFD1_k127_3319280_1	1150599.MPHLEI_12591	8.162e-158	501.0	COG2224@1|root,COG2224@2|Bacteria,2I926@201174|Actinobacteria,232A9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Isocitrate lyase	aceAb	GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HFD1_k127_3319280_0	1121920.AUAU01000013_gene1698	2.107e-264	821.0	COG2225@1|root,COG2225@2|Bacteria,3Y4MK@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HFD1_k127_3358693_0	1123267.JONN01000001_gene1884	1.612e-201	642.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2U0VY@28211|Alphaproteobacteria,2K0U8@204457|Sphingomonadales	204457|Sphingomonadales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HFD1_k127_3358693_1	1123267.JONN01000001_gene2058	9.529e-93	311.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria,2K9IU@204457|Sphingomonadales	204457|Sphingomonadales	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HFD1_k127_3358693_3	452662.SJA_C1-33920	8.595e-62	216.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,2K4FF@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HFD1_k127_3358693_2	1123267.JONN01000001_gene2064	4.682e-69	237.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2K4IC@204457|Sphingomonadales	204457|Sphingomonadales	S	FeS assembly SUF system protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HFD1_k127_3367828_2	1123267.JONN01000001_gene1736	2.291e-08	60.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,2K2JH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,YkuD
HFD1_k127_3367828_1	1380391.JIAS01000003_gene1903	2.532e-62	217.0	COG0346@1|root,COG0346@2|Bacteria,1N3K0@1224|Proteobacteria,2UEB4@28211|Alphaproteobacteria,2JWKN@204441|Rhodospirillales	204441|Rhodospirillales	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3367828_0	1123267.JONN01000001_gene1738	8.637e-296	911.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,2JZZK@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HFD1_k127_3375743_3	391600.ABRU01000025_gene1162	2.129e-38	148.0	COG4319@1|root,COG4319@2|Bacteria,1N6PB@1224|Proteobacteria,2UGDK@28211|Alphaproteobacteria,2KIVC@204458|Caulobacterales	204458|Caulobacterales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HFD1_k127_3375743_1	1123267.JONN01000001_gene1278	1.763e-184	592.0	COG3667@1|root,COG3667@2|Bacteria,1R6TA@1224|Proteobacteria,2U52R@28211|Alphaproteobacteria,2K3M1@204457|Sphingomonadales	204457|Sphingomonadales	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3375743_2	13689.BV96_04538	1.706e-48	183.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2U98F@28211|Alphaproteobacteria,2K3VR@204457|Sphingomonadales	204457|Sphingomonadales	L	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind
HFD1_k127_3375743_0	426114.THI_3098	2.31e-289	904.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,1KKHS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	E1-E2 ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HFD1_k127_339275_0	685778.AORL01000010_gene2778	0.0	1035.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,2K25A@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD1_k127_339275_9	1174684.EBMC1_11590	2.55e-29	122.0	2E32R@1|root,32Y2Y@2|Bacteria,1N91I@1224|Proteobacteria,2UI6P@28211|Alphaproteobacteria,2K701@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_339275_10	1123240.ATVO01000010_gene655	1.393e-10	64.0	COG2906@1|root,COG2906@2|Bacteria	2|Bacteria	P	2 iron, 2 sulfur cluster binding	bfd	GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
HFD1_k127_339275_5	194867.ALBQ01000011_gene17	3.893e-75	255.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2U70I@28211|Alphaproteobacteria,2K3XA@204457|Sphingomonadales	204457|Sphingomonadales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HFD1_k127_339275_7	1123267.JONN01000001_gene1723	2.156e-65	226.0	COG2198@1|root,COG2198@2|Bacteria,1NMJT@1224|Proteobacteria,2UQPF@28211|Alphaproteobacteria,2K588@204457|Sphingomonadales	204457|Sphingomonadales	T	Hpt domain	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt
HFD1_k127_339275_1	1123267.JONN01000001_gene1722	4.173e-218	684.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,2K0SQ@204457|Sphingomonadales	204457|Sphingomonadales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HFD1_k127_339275_2	1123267.JONN01000001_gene1721	3.066e-178	571.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,2K0GW@204457|Sphingomonadales	204457|Sphingomonadales	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HFD1_k127_339275_8	1123267.JONN01000001_gene1720	6.471e-55	200.0	COG4649@1|root,COG4649@2|Bacteria,1P2GI@1224|Proteobacteria,2UCFZ@28211|Alphaproteobacteria,2K40C@204457|Sphingomonadales	204457|Sphingomonadales	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HFD1_k127_339275_6	1384054.N790_10150	2.671e-71	245.0	COG1309@1|root,COG1309@2|Bacteria,1RBV0@1224|Proteobacteria	1224|Proteobacteria	K	COG1309 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD1_k127_339275_4	196490.AUEZ01000066_gene2429	2.719e-121	393.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria,2U3GM@28211|Alphaproteobacteria,3JTJ2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HFD1_k127_339275_3	1123267.JONN01000001_gene1719	3.98e-146	467.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria,2K1CJ@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HFD1_k127_34368_1	1123267.JONN01000001_gene1908	1.382e-72	252.0	COG4993@1|root,COG4993@2|Bacteria,1N7DU@1224|Proteobacteria,2U6Z1@28211|Alphaproteobacteria,2K133@204457|Sphingomonadales	204457|Sphingomonadales	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_34368_0	1123267.JONN01000001_gene1907	2.524e-157	503.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,2K121@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HFD1_k127_3437493_2	1122612.AUBA01000013_gene283	1.303e-15	77.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2K2JW@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HFD1_k127_3437493_0	1123267.JONN01000001_gene902	2.935e-189	595.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,2K1JI@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HFD1_k127_3437493_1	1123267.JONN01000001_gene904	2.049e-63	221.0	COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,2U5TK@28211|Alphaproteobacteria,2K3A3@204457|Sphingomonadales	204457|Sphingomonadales	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HFD1_k127_3489982_6	1123267.JONN01000001_gene1971	9.04e-73	252.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,2K26X@204457|Sphingomonadales	204457|Sphingomonadales	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_3489982_8	685778.AORL01000002_gene1946	6.548e-38	147.0	COG1522@1|root,COG1522@2|Bacteria,1RCEQ@1224|Proteobacteria,2U6I5@28211|Alphaproteobacteria,2K497@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
HFD1_k127_3489982_0	1123267.JONN01000002_gene242	1.75e-288	899.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,2K1XU@204457|Sphingomonadales	204457|Sphingomonadales	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HFD1_k127_3489982_2	1114964.L485_16605	1.928e-99	339.0	COG2244@1|root,COG2244@2|Bacteria,1RDQG@1224|Proteobacteria,2U27A@28211|Alphaproteobacteria,2K2K5@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
HFD1_k127_3489982_1	1071679.BG57_00460	5.057e-131	422.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1JZYF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HFD1_k127_3489982_7	1123267.JONN01000002_gene240	4.536e-72	251.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	sugar phosphatases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HFD1_k127_3489982_5	1096930.L284_05800	1.916e-80	278.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,2K293@204457|Sphingomonadales	204457|Sphingomonadales	M	3-deoxy-manno-octulosonate cytidylyltransferase	-	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HFD1_k127_3489982_3	1122180.Lokhon_00786	7.232e-94	317.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria,2P7TE@245186|Loktanella	28211|Alphaproteobacteria	M	SIS domain	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HFD1_k127_3489982_4	1123269.NX02_14195	3.336e-86	289.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TUFB@28211|Alphaproteobacteria,2K0FM@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HFD1_k127_3531745_2	194867.ALBQ01000004_gene3606	1.451e-159	520.0	COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,2K0XJ@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane metal-binding protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
HFD1_k127_3531745_1	1081640.AGFU01000021_gene1987	5.748e-214	674.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,2K09A@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HFD1_k127_3531745_0	1123267.JONN01000001_gene1317	9.358e-247	766.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2K0JS@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HFD1_k127_3531745_5	1123267.JONN01000001_gene1318	7.485e-96	330.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2U3HG@28211|Alphaproteobacteria,2K0AE@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_3531745_6	1123267.JONN01000001_gene1319	4.905e-42	168.0	COG5330@1|root,COG5330@2|Bacteria	2|Bacteria	K	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF2336,LRV,PSCyt2,PSD1,SHD1
HFD1_k127_3531745_4	1123267.JONN01000001_gene1320	1.074e-122	406.0	2AKKZ@1|root,31BDD@2|Bacteria,1NNE3@1224|Proteobacteria,2UMPR@28211|Alphaproteobacteria,2K4ZT@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3531745_3	1123267.JONN01000001_gene1321	1.36e-143	477.0	COG1511@1|root,COG1511@2|Bacteria,1QVM2@1224|Proteobacteria,2TWI1@28211|Alphaproteobacteria,2KEGK@204457|Sphingomonadales	204457|Sphingomonadales	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3559652_5	1192759.AKIB01000116_gene3810	1.967e-23	101.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,2K0F4@204457|Sphingomonadales	204457|Sphingomonadales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HFD1_k127_3559652_4	1123267.JONN01000002_gene73	2.71e-55	199.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,2K4GE@204457|Sphingomonadales	204457|Sphingomonadales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HFD1_k127_3559652_6	1123267.JONN01000002_gene74	7.844e-10	62.0	COG5570@1|root,COG5570@2|Bacteria,1NGRE@1224|Proteobacteria,2UJAX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Small protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HFD1_k127_3559652_7	450851.PHZ_c3289	2.238e-06	51.0	COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,2KHHR@204458|Caulobacterales	204458|Caulobacterales	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HFD1_k127_3559652_3	1123267.JONN01000002_gene76	4.19e-56	203.0	COG5317@1|root,COG5317@2|Bacteria,1RJIA@1224|Proteobacteria,2U9ID@28211|Alphaproteobacteria,2K5B1@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1465)	-	-	-	ko:K13592	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	DUF1465
HFD1_k127_3559652_1	1081640.AGFU01000011_gene1260	2.107e-151	484.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,2K0V5@204457|Sphingomonadales	204457|Sphingomonadales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HFD1_k127_3559652_2	1112216.JH594425_gene732	2.826e-149	479.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2TSIP@28211|Alphaproteobacteria,2K0VH@204457|Sphingomonadales	204457|Sphingomonadales	M	epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HFD1_k127_3559652_0	161528.ED21_21814	0.0	1615.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K2G6@204457|Sphingomonadales	204457|Sphingomonadales	EQ	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HFD1_k127_3566767_3	983920.Y88_0936	4.34e-16	81.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2U74H@28211|Alphaproteobacteria,2K1RJ@204457|Sphingomonadales	204457|Sphingomonadales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HFD1_k127_3566767_0	1123267.JONN01000002_gene167	3.447e-124	404.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria,2K19H@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HFD1_k127_3566767_2	1123267.JONN01000002_gene166	2.05e-25	107.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,2K6WZ@204457|Sphingomonadales	204457|Sphingomonadales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HFD1_k127_3566767_1	1123267.JONN01000002_gene165	1.862e-113	369.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,2K0D3@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
HFD1_k127_3583347_13	392499.Swit_1351	1.202e-18	85.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,2K54N@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HFD1_k127_3583347_0	279238.Saro_1252	7.232e-164	517.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,2JZZY@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HFD1_k127_3583347_10	1123267.JONN01000001_gene1553	6.46e-48	172.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria,2K53B@204457|Sphingomonadales	204457|Sphingomonadales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HFD1_k127_3583347_7	1123267.JONN01000001_gene1552	4.336e-61	213.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,2K4K0@204457|Sphingomonadales	204457|Sphingomonadales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HFD1_k127_3583347_1	1123267.JONN01000001_gene1551	2.61e-136	436.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,2K04S@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HFD1_k127_3583347_4	1123267.JONN01000001_gene1550	1.014e-80	269.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,2K3Z0@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HFD1_k127_3583347_12	1123267.JONN01000001_gene1549	3.567e-22	99.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,2K6RZ@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HFD1_k127_3583347_11	1123267.JONN01000001_gene1548	5.361e-35	140.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,2K5VH@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HFD1_k127_3583347_6	1123267.JONN01000001_gene1547	1.085e-69	237.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria,2K4G3@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HFD1_k127_3583347_9	392499.Swit_1342	1.152e-48	176.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria,2K52R@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HFD1_k127_3583347_2	1123267.JONN01000001_gene1545	2.047e-101	335.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria,2K0S5@204457|Sphingomonadales	204457|Sphingomonadales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HFD1_k127_3583347_8	1123267.JONN01000001_gene1544	3.692e-51	182.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria,2K53G@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HFD1_k127_3583347_5	1123267.JONN01000001_gene1543	9.205e-73	246.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,2K3ZU@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HFD1_k127_3583347_3	1123267.JONN01000001_gene1542	2.454e-89	300.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,2K149@204457|Sphingomonadales	204457|Sphingomonadales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HFD1_k127_3583347_14	1122970.AUHC01000001_gene807	6.585e-15	78.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,2K52X@204457|Sphingomonadales	204457|Sphingomonadales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HFD1_k127_3619794_13	1054213.HMPREF9946_02327	9.002e-61	219.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2U5Y7@28211|Alphaproteobacteria,2JSMM@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HFD1_k127_3619794_19	1123267.JONN01000001_gene482	4.886e-29	123.0	2BSC6@1|root,32ME1@2|Bacteria,1PPBT@1224|Proteobacteria,2V1U9@28211|Alphaproteobacteria,2KC1J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3619794_14	1123267.JONN01000001_gene2473	4.972e-49	179.0	2E3B5@1|root,32YAP@2|Bacteria,1N7KQ@1224|Proteobacteria,2UHG1@28211|Alphaproteobacteria,2K43M@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HFD1_k127_3619794_3	1123267.JONN01000001_gene2471	1.32e-165	527.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,2JZUH@204457|Sphingomonadales	204457|Sphingomonadales	G	in Escherichia coli this protein forms a dimer and binds manganese	glpX	-	3.1.3.11,3.1.3.37	ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HFD1_k127_3619794_1	1030157.AFMP01000016_gene2436	8.146e-242	775.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,2K0VW@204457|Sphingomonadales	204457|Sphingomonadales	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HFD1_k127_3619794_7	876269.ARWA01000001_gene1462	4.647e-106	352.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2U0IR@28211|Alphaproteobacteria,3NBY1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	cyoA	-	1.10.3.10	ko:K02297	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX2,COX_ARM
HFD1_k127_3619794_0	1040982.AXAL01000051_gene5958	6.058e-308	955.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,43MNF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	cyoB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
HFD1_k127_3619794_10	1081640.AGFU01000002_gene454	2.913e-78	268.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TSVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	CytOchrome o ubiquinol oxidase	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
HFD1_k127_3619794_18	1144305.PMI02_05519	6.111e-38	155.0	COG3125@1|root,COG3125@2|Bacteria,1RHE5@1224|Proteobacteria,2U67R@28211|Alphaproteobacteria,2K6B4@204457|Sphingomonadales	204457|Sphingomonadales	C	Prokaryotic Cytochrome C oxidase subunit IV	-	-	-	ko:K02300	ko00190,ko01100,map00190,map01100	M00417	-	-	ko00000,ko00001,ko00002	3.D.4.5	-	-	COX4_pro
HFD1_k127_3619794_9	1088721.NSU_4744	5.436e-86	301.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2U0C9@28211|Alphaproteobacteria,2K374@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HFD1_k127_3619794_5	13689.BV96_00641	7.667e-138	443.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria,2K143@204457|Sphingomonadales	204457|Sphingomonadales	S	Serine hydrolase involved in the detoxification of formaldehyde	-	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
HFD1_k127_3619794_15	290400.Jann_0773	1.581e-48	175.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,2UA4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_3619794_8	443598.AUFA01000004_gene5313	2.172e-90	301.0	COG3791@1|root,COG3791@2|Bacteria,1MX4A@1224|Proteobacteria,2TSAN@28211|Alphaproteobacteria,3JRS6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione	gfa	-	4.4.1.22	ko:K03396	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R06982	RC00069,RC01707	ko00000,ko00001,ko01000	-	-	-	GFA
HFD1_k127_3619794_2	1123267.JONN01000001_gene2463	2.55e-223	694.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2K04T@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HFD1_k127_3619794_11	190650.CC_0409	1.198e-77	267.0	COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,2TUIN@28211|Alphaproteobacteria,2KGIT@204458|Caulobacterales	204458|Caulobacterales	F	glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase
HFD1_k127_3619794_12	1123267.JONN01000001_gene2462	4.12e-73	257.0	COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,2TTYG@28211|Alphaproteobacteria,2K4G4@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HFD1_k127_3619794_6	394221.Mmar10_2692	1.141e-114	375.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,43ZXQ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_38145	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HFD1_k127_3619794_4	1082933.MEA186_16732	2.764e-141	458.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,43J1N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_3619794_16	394221.Mmar10_2689	9.051e-46	171.0	COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2U9A9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HFD1_k127_3619794_17	266117.Rxyl_2279	2.195e-38	149.0	COG0365@1|root,COG0365@2|Bacteria,2GJVK@201174|Actinobacteria	201174|Actinobacteria	I	Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HFD1_k127_3636196_8	296591.Bpro_0336	1.529e-18	89.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,4ADS8@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_3636196_1	702113.PP1Y_AT23285	2.592e-103	341.0	293CN@1|root,2Z9VJ@2|Bacteria,1MXNG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3636196_9	1088721.NSU_3061	4.853e-12	74.0	2E92Z@1|root,333BY@2|Bacteria,1N8J4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3636196_6	1007104.SUS17_3579	4.74e-38	151.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UB52@28211|Alphaproteobacteria,2KDCN@204457|Sphingomonadales	204457|Sphingomonadales	O	small heat shock protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HFD1_k127_3636196_0	1234595.C725_0236	3.467e-147	476.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,4BPD3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD1_k127_3636196_4	1123267.JONN01000002_gene271	1.087e-57	214.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,2K353@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HFD1_k127_3636196_2	1123267.JONN01000002_gene270	1.155e-82	278.0	COG5465@1|root,COG5465@2|Bacteria,1REC1@1224|Proteobacteria,2U7UP@28211|Alphaproteobacteria,2K1T3@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
HFD1_k127_3636196_7	1550073.JROH01000012_gene2552	2.788e-29	121.0	COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,2K74V@204457|Sphingomonadales	204457|Sphingomonadales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
HFD1_k127_3636196_5	685778.AORL01000023_gene2124	1.156e-41	161.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2K4UV@204457|Sphingomonadales	204457|Sphingomonadales	T	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	bzrP	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HFD1_k127_3636196_3	392499.Swit_4468	2.607e-79	267.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,2K0J2@204457|Sphingomonadales	204457|Sphingomonadales	J	Hemolysin	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HFD1_k127_3644299_0	685778.AORL01000001_gene165	1.527e-216	682.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2K1TQ@204457|Sphingomonadales	204457|Sphingomonadales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HFD1_k127_3644299_1	1007104.SUS17_1743	5.009e-130	431.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K13N@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HFD1_k127_3644299_2	1030157.AFMP01000031_gene2978	1.195e-125	406.0	COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,2TU8S@28211|Alphaproteobacteria,2K13M@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate	astD	-	1.2.1.71	ko:K06447	ko00330,ko01100,map00330,map01100	-	R05049	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD1_k127_3657670_4	1071679.BG57_08035	2.621e-62	227.0	COG3515@1|root,COG3515@2|Bacteria,1NK35@1224|Proteobacteria,2VQ1C@28216|Betaproteobacteria,1KH8E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ImpA, N-terminal, type VI secretion system	-	-	-	ko:K11902	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	ImpA_N
HFD1_k127_3657670_3	62928.azo3895	5.888e-85	284.0	COG3516@1|root,COG3516@2|Bacteria,1RAZQ@1224|Proteobacteria,2VQ4P@28216|Betaproteobacteria,2KZTV@206389|Rhodocyclales	206389|Rhodocyclales	S	Type VI secretion system, VipA, VC_A0107 or Hcp2	-	-	-	ko:K11901	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	T6SS_VipA
HFD1_k127_3657670_0	1288494.EBAPG3_16540	1.342e-283	880.0	COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,2VKCP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	type VI secretion protein	-	-	-	ko:K11900	ko02025,map02025	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	VipB
HFD1_k127_3657670_5	313589.JNB_18898	2.241e-51	187.0	COG3157@1|root,COG3157@2|Bacteria,2IP19@201174|Actinobacteria,4FI68@85021|Intrasporangiaceae	201174|Actinobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HFD1_k127_3657670_7	1288494.EBAPG3_16520	4.188e-35	139.0	COG3157@1|root,COG3157@2|Bacteria,1N3Z0@1224|Proteobacteria,2VURN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HFD1_k127_3657670_2	1288494.EBAPG3_16510	8.739e-99	329.0	COG4455@1|root,COG4455@2|Bacteria,1MWHI@1224|Proteobacteria,2VKHG@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Virulence protein SciE type	-	-	-	ko:K11898	-	-	-	-	ko00000,ko02044	-	-	-	ImpE
HFD1_k127_3657670_6	1288494.EBAPG3_16500	1.471e-47	178.0	COG3518@1|root,COG3518@2|Bacteria,1RF51@1224|Proteobacteria,2VRQP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM type VI secretion system lysozyme-related protein	-	-	-	ko:K11897	-	M00334	-	-	ko00000,ko00002,ko02044	-	-	-	GPW_gp25
HFD1_k127_3657670_1	1288494.EBAPG3_16490	4.954e-150	482.0	COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,2VHXS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Type VI secretion protein	-	-	-	ko:K11896	-	M00334	-	-	ko00000,ko00002,ko02044	3.A.23.1	-	-	T6SS_TssF
HFD1_k127_3683761_13	383381.EH30_04550	1.15e-99	327.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K2G6@204457|Sphingomonadales	204457|Sphingomonadales	EQ	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HFD1_k127_3683761_14	1479239.JQMU01000001_gene2178	1.045e-87	302.0	COG3819@1|root,COG3819@2|Bacteria,1MWFM@1224|Proteobacteria,2U5DR@28211|Alphaproteobacteria,2K0TR@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF969
HFD1_k127_3683761_10	383381.EH30_04560	1.343e-117	390.0	COG3817@1|root,COG3817@2|Bacteria,1MXGD@1224|Proteobacteria,2TUDC@28211|Alphaproteobacteria,2K1SX@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF979
HFD1_k127_3683761_9	629773.AORY01000005_gene2616	6.245e-135	437.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,2TTDU@28211|Alphaproteobacteria,2K0FT@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
HFD1_k127_3683761_18	1206725.BAFU01000029_gene3010	1.2e-53	202.0	COG3491@1|root,COG3491@2|Bacteria,2HJ6C@201174|Actinobacteria,4G5GY@85025|Nocardiaceae	201174|Actinobacteria	C	non-haem dioxygenase in morphine synthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
HFD1_k127_3683761_7	1007104.SUS17_2196	6.647e-150	489.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TUFK@28211|Alphaproteobacteria,2K0NW@204457|Sphingomonadales	204457|Sphingomonadales	M	RND efflux system, outer membrane lipoprotein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HFD1_k127_3683761_0	1449076.JOOE01000004_gene615	0.0	1438.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales	204457|Sphingomonadales	V	Efflux pump membrane transporter	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HFD1_k127_3683761_8	1081640.AGFU01000100_gene2035	2.561e-144	468.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSW4@28211|Alphaproteobacteria,2K1BG@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD,HlyD_D23
HFD1_k127_3683761_15	1304275.C41B8_00915	4.328e-85	298.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST,RimK
HFD1_k127_3683761_12	1217720.ALOX01000033_gene137	3.914e-105	349.0	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,2U2U3@28211|Alphaproteobacteria,2JS2F@204441|Rhodospirillales	204441|Rhodospirillales	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3683761_16	1336208.JADY01000010_gene3349	2.152e-56	211.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,2JTHZ@204441|Rhodospirillales	204441|Rhodospirillales	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
HFD1_k127_3683761_3	1088721.NSU_0816	1.209e-224	713.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HFD1_k127_3683761_20	1040986.ATYO01000009_gene2377	2.231e-42	168.0	COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,2UDFS@28211|Alphaproteobacteria,43HNH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_3683761_19	570967.JMLV01000001_gene2799	1.791e-42	168.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,2VGKJ@28211|Alphaproteobacteria,2JZ9B@204441|Rhodospirillales	204441|Rhodospirillales	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
HFD1_k127_3683761_4	1123267.JONN01000001_gene1482	5.036e-222	706.0	COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria,2K1DC@204457|Sphingomonadales	204457|Sphingomonadales	H	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_3683761_6	1123267.JONN01000001_gene1003	1.022e-150	492.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,2K0FR@204457|Sphingomonadales	204457|Sphingomonadales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HFD1_k127_3683761_1	1123267.JONN01000001_gene1004	2.019e-237	756.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2JZYI@204457|Sphingomonadales	204457|Sphingomonadales	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HFD1_k127_3683761_17	1123267.JONN01000001_gene1005	7.244e-56	201.0	2923J@1|root,2ZPNK@2|Bacteria,1NHX1@1224|Proteobacteria,2UC0M@28211|Alphaproteobacteria,2K5BN@204457|Sphingomonadales	204457|Sphingomonadales	S	rod shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HFD1_k127_3683761_11	1123267.JONN01000001_gene1006	6.139e-117	382.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,2K18A@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HFD1_k127_3683761_5	1144307.PMI04_00238	1.405e-190	603.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria,2K10A@204457|Sphingomonadales	204457|Sphingomonadales	D	rod shape-determining protein MreB	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HFD1_k127_3683761_2	1123267.JONN01000001_gene1008	3.399e-234	737.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,2K2AP@204457|Sphingomonadales	204457|Sphingomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD1_k127_3689906_0	392499.Swit_0232	2.217e-130	425.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria,2K0B3@204457|Sphingomonadales	204457|Sphingomonadales	S	DNA recombination protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD1_k127_3689906_3	1096930.L284_20960	5.435e-42	169.0	COG1145@1|root,32SB1@2|Bacteria,1N096@1224|Proteobacteria,2U9JE@28211|Alphaproteobacteria,2K59E@204457|Sphingomonadales	204457|Sphingomonadales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF326
HFD1_k127_3689906_2	1123267.JONN01000002_gene149	9.298e-77	260.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,2K3Y2@204457|Sphingomonadales	204457|Sphingomonadales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HFD1_k127_3689906_1	685778.AORL01000021_gene776	4.034e-102	335.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria,2K15N@204457|Sphingomonadales	204457|Sphingomonadales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HFD1_k127_3754097_3	1123267.JONN01000002_gene251	1.222e-59	222.0	COG2234@1|root,COG2234@2|Bacteria,1R56X@1224|Proteobacteria,2U2G7@28211|Alphaproteobacteria,2K2WC@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD1_k127_3754097_2	1123269.NX02_13000	1.966e-70	254.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,2K414@204457|Sphingomonadales	204457|Sphingomonadales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HFD1_k127_3754097_4	1123269.NX02_13010	2.483e-56	199.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,2K4GC@204457|Sphingomonadales	204457|Sphingomonadales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HFD1_k127_3754097_1	1123267.JONN01000002_gene249	4.006e-130	420.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,2JZVZ@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HFD1_k127_3754097_0	1123267.JONN01000002_gene247	3.065e-132	428.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2TU6F@28211|Alphaproteobacteria,2K1CC@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HFD1_k127_3760306_3	627192.SLG_11890	1.51e-07	52.0	COG0412@1|root,COG0412@2|Bacteria,1NRB4@1224|Proteobacteria,2TU91@28211|Alphaproteobacteria,2K272@204457|Sphingomonadales	204457|Sphingomonadales	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HFD1_k127_3760306_0	1280946.HY29_09170	2.317e-78	268.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,43Y44@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase	gstch8	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HFD1_k127_3760306_1	1449076.JOOE01000002_gene938	2.599e-58	207.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria,2K4TF@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HFD1_k127_3760306_2	1123267.JONN01000002_gene157	3.231e-55	196.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_3857055_4	1123267.JONN01000001_gene1691	2.963e-29	123.0	COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2TSSQ@28211|Alphaproteobacteria,2K1HG@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_2
HFD1_k127_3857055_6	1379701.JPJC01000034_gene1828	0.0006879	45.0	2A3EZ@1|root,30RXP@2|Bacteria,1Q8F0@1224|Proteobacteria,2VEMU@28211|Alphaproteobacteria,2K84Y@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3857055_1	1123267.JONN01000001_gene1690	1.462e-137	448.0	COG0784@1|root,COG1595@1|root,COG0784@2|Bacteria,COG1595@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,2K0S1@204457|Sphingomonadales	204457|Sphingomonadales	T	In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
HFD1_k127_3857055_2	1123267.JONN01000001_gene1689	2.84e-112	364.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,2K0TM@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_3857055_0	1123267.JONN01000001_gene1687	1.087e-321	1009.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2K1YP@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HFD1_k127_3857055_3	1123267.JONN01000001_gene1686	4.829e-40	151.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2K4IB@204457|Sphingomonadales	204457|Sphingomonadales	O	Alkyl hydroperoxide reductase	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD1_k127_3871997_1	1449049.JONW01000005_gene1634	2.292e-138	452.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,2KFZ9@204458|Caulobacterales	204458|Caulobacterales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HFD1_k127_3871997_0	69395.JQLZ01000004_gene782	8.34e-143	458.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2KFF0@204458|Caulobacterales	204458|Caulobacterales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HFD1_k127_3871997_2	13690.CP98_00505	2.181e-66	244.0	COG1566@1|root,COG1566@2|Bacteria,1QUDS@1224|Proteobacteria,2TW6B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HFD1_k127_3871997_3	629773.AORY01000004_gene90	1.239e-35	141.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2K0XN@204457|Sphingomonadales	204457|Sphingomonadales	MU	COG1538 Outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HFD1_k127_3978644_0	570967.JMLV01000006_gene275	6.399e-196	625.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HFD1_k127_3983918_16	1122619.KB892368_gene2455	1.039e-40	151.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,3T1DU@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
HFD1_k127_3983918_0	1500306.JQLA01000003_gene4311	1.19e-284	880.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria	1224|Proteobacteria	C	nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
HFD1_k127_3983918_10	1280953.HOC_17781	1.579e-55	202.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,2U19T@28211|Alphaproteobacteria,43XWP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	nitrate reductase molybdenum cofactor assembly chaperone	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
HFD1_k127_3983918_5	426355.Mrad2831_2589	1.212e-89	303.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2TTDB@28211|Alphaproteobacteria,1JU67@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	TIGRFAM respiratory nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
HFD1_k127_3983918_12	1089552.KI911559_gene3043	3.084e-49	192.0	COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2U3I3@28211|Alphaproteobacteria,2JS8D@204441|Rhodospirillales	204441|Rhodospirillales	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase
HFD1_k127_3983918_19	1207063.P24_01435	9.817e-08	57.0	2E09K@1|root,33KX4@2|Bacteria,1NQ3V@1224|Proteobacteria,2UMKA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_3983918_3	1030157.AFMP01000004_gene2001	2.592e-104	350.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,2K206@204457|Sphingomonadales	204457|Sphingomonadales	S	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HFD1_k127_3983918_4	1030157.AFMP01000004_gene2000	1.13e-102	340.0	COG4117@1|root,COG4117@2|Bacteria,1MX97@1224|Proteobacteria,2U0ZF@28211|Alphaproteobacteria,2K0DE@204457|Sphingomonadales	204457|Sphingomonadales	C	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD1_k127_3983918_9	414684.RC1_2984	3.377e-63	229.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2TV0E@28211|Alphaproteobacteria,2JRE3@204441|Rhodospirillales	204441|Rhodospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_3983918_8	1121124.JNIX01000007_gene537	1.94e-71	248.0	COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria,2U7QA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD1_k127_3983918_14	450851.PHZ_c0702	7.597e-45	180.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2TV2G@28211|Alphaproteobacteria,2KHD6@204458|Caulobacterales	204458|Caulobacterales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HFD1_k127_3983918_2	366602.Caul_3856	1.069e-128	422.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,2KHZV@204458|Caulobacterales	204458|Caulobacterales	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_N
HFD1_k127_3983918_11	1112214.AHIS01000081_gene3495	1.043e-54	202.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,2K4GG@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	-	-	-	-	-	-	-	-	-	-	-	-	MoaC
HFD1_k127_3983918_6	983920.Y88_2687	3.527e-83	278.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria,2K4AU@204457|Sphingomonadales	204457|Sphingomonadales	H	May be involved in the biosynthesis of molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HFD1_k127_3983918_15	1121123.AUAO01000001_gene747	1.113e-42	161.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2U73K@28211|Alphaproteobacteria,2KGU8@204458|Caulobacterales	204458|Caulobacterales	H	Molybdopterin	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HFD1_k127_3983918_13	1123267.JONN01000001_gene860	2.204e-46	174.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,2KD2A@204457|Sphingomonadales	204457|Sphingomonadales	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HFD1_k127_3983918_1	1123267.JONN01000001_gene858	1.031e-196	622.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,2JZUT@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized ACR, YdiU/UPF0061 family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
HFD1_k127_3983918_7	1123267.JONN01000001_gene857	5.59e-74	258.0	COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,2TU8S@28211|Alphaproteobacteria,2K13M@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate	astD	-	1.2.1.71	ko:K06447	ko00330,ko01100,map00330,map01100	-	R05049	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HFD1_k127_3994222_6	1123267.JONN01000002_gene318	2.246e-124	400.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,2K0W6@204457|Sphingomonadales	204457|Sphingomonadales	V	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Amidase_2
HFD1_k127_3994222_4	1123267.JONN01000002_gene317	2.237e-125	407.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,2K3X1@204457|Sphingomonadales	204457|Sphingomonadales	NT	COG1352 Methylase of chemotaxis methyl-accepting proteins	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
HFD1_k127_3994222_5	1123267.JONN01000002_gene316	2.244e-124	408.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2K0GS@204457|Sphingomonadales	204457|Sphingomonadales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HFD1_k127_3994222_8	1123267.JONN01000002_gene315	1.085e-69	237.0	COG0745@1|root,COG0745@2|Bacteria,1QU38@1224|Proteobacteria,2TVXD@28211|Alphaproteobacteria,2KEGQ@204457|Sphingomonadales	204457|Sphingomonadales	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HFD1_k127_3994222_9	1123267.JONN01000002_gene314	5.673e-59	208.0	COG0835@1|root,COG0835@2|Bacteria,1N88R@1224|Proteobacteria,2UGI7@28211|Alphaproteobacteria,2K55G@204457|Sphingomonadales	204457|Sphingomonadales	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HFD1_k127_3994222_0	1123267.JONN01000002_gene313	0.0	1056.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2K0Z1@204457|Sphingomonadales	204457|Sphingomonadales	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
HFD1_k127_3994222_7	1123267.JONN01000002_gene246	1.352e-88	298.0	COG5385@1|root,COG5385@2|Bacteria,1MVEY@1224|Proteobacteria,2TSE6@28211|Alphaproteobacteria,2K0H0@204457|Sphingomonadales	204457|Sphingomonadales	S	Histidine phosphotransferase C-terminal domain	-	-	-	ko:K13588	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001	-	-	-	HPTransfase
HFD1_k127_3994222_2	1123267.JONN01000002_gene245	6.119e-149	477.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,2K1VU@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HFD1_k127_3994222_1	1123267.JONN01000002_gene244	2.326e-164	520.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,2K1G6@204457|Sphingomonadales	204457|Sphingomonadales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HFD1_k127_3994222_3	1123267.JONN01000001_gene1971	6.294e-133	436.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,2K26X@204457|Sphingomonadales	204457|Sphingomonadales	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_400825_3	1123267.JONN01000001_gene1648	1.713e-73	252.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,2U2M4@28211|Alphaproteobacteria,2K040@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HFD1_k127_400825_4	1123267.JONN01000001_gene1647	1.608e-45	166.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2K55Y@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
HFD1_k127_400825_9	1550073.JROH01000027_gene941	1.376e-29	121.0	COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria,2K5YQ@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the BolA IbaG family	-	-	-	-	-	-	-	-	-	-	-	-	BolA
HFD1_k127_400825_7	745310.G432_15480	2.943e-35	143.0	COG5467@1|root,COG5467@2|Bacteria,1MZRN@1224|Proteobacteria,2UC1G@28211|Alphaproteobacteria,2K533@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF1476)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1476
HFD1_k127_400825_10	1449076.JOOE01000003_gene3366	1.954e-25	109.0	2DRS8@1|root,33CUB@2|Bacteria,1QV1W@1224|Proteobacteria,2UJDK@28211|Alphaproteobacteria,2KERH@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_400825_0	13689.BV96_00310	9.667e-190	612.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,2K0ZF@204457|Sphingomonadales	204457|Sphingomonadales	P	Sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HFD1_k127_400825_2	279238.Saro_0566	8.715e-120	389.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2TQS5@28211|Alphaproteobacteria,2JZXA@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	scoB	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD1_k127_400825_8	1300345.LF41_2955	2.689e-31	128.0	2DEWU@1|root,2ZPJP@2|Bacteria,1P3DY@1224|Proteobacteria,1T86W@1236|Gammaproteobacteria,1XA81@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_400825_1	745310.G432_14065	1.179e-129	419.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria,2K0EF@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD1_k127_400825_5	1502850.FG91_01550	2.706e-42	163.0	COG3193@1|root,COG3193@2|Bacteria	2|Bacteria	-	-	MA20_43165	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HFD1_k127_400825_6	1282360.ABAC460_23415	4.485e-42	158.0	COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,2UIQ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4037024_1	1123267.JONN01000001_gene921	5.78e-262	820.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0TH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD1_k127_4037024_12	13690.CP98_00125	3.074e-44	171.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria,2K7DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HFD1_k127_4037024_2	1247963.JPHU01000001_gene1893	2.364e-241	758.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD1_k127_4037024_10	1449076.JOOE01000001_gene1961	2.413e-56	202.0	2CKCH@1|root,331PP@2|Bacteria,1QYXW@1224|Proteobacteria,2TY15@28211|Alphaproteobacteria,2KEKB@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4037024_0	1123267.JONN01000001_gene919	1.62e-288	893.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2JZZG@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HFD1_k127_4037024_7	13689.BV96_01336	1.712e-108	363.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,2JZVH@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_4037024_3	1123267.JONN01000001_gene917	2.891e-197	629.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,2K1JA@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
HFD1_k127_4037024_11	1123267.JONN01000001_gene916	3.051e-50	182.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,2K65M@204457|Sphingomonadales	204457|Sphingomonadales	T	Serine kinase of the HPr protein, regulates carbohydrate metabolism	-	-	-	-	-	-	-	-	-	-	-	-	Hpr_kinase_C
HFD1_k127_4037024_5	1123267.JONN01000001_gene915	5.046e-121	400.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2TTI4@28211|Alphaproteobacteria,2K01M@204457|Sphingomonadales	204457|Sphingomonadales	T	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HFD1_k127_4037024_9	745310.G432_02955	2.035e-62	218.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,2K4MZ@204457|Sphingomonadales	204457|Sphingomonadales	G	PTS fructose transporter subunit IIA	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
HFD1_k127_4037024_14	1123267.JONN01000001_gene913	1.14e-27	119.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2UC0H@28211|Alphaproteobacteria,2K638@204457|Sphingomonadales	204457|Sphingomonadales	G	COG1925 Phosphotransferase system, HPr-related proteins	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HFD1_k127_4037024_6	1346791.M529_07685	5.928e-114	374.0	COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,2TT4Y@28211|Alphaproteobacteria,2K16F@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD1_k127_4037024_4	1090320.KB900605_gene2683	1.199e-161	521.0	COG0531@1|root,COG0531@2|Bacteria,1MXF4@1224|Proteobacteria,2VBYZ@28211|Alphaproteobacteria,2K0Y9@204457|Sphingomonadales	204457|Sphingomonadales	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HFD1_k127_4037024_13	1123267.JONN01000001_gene910	9.745e-34	137.0	COG3187@1|root,COG3650@1|root,COG3187@2|Bacteria,COG3650@2|Bacteria,1MXIV@1224|Proteobacteria,2U2HT@28211|Alphaproteobacteria,2K6CZ@204457|Sphingomonadales	204457|Sphingomonadales	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
HFD1_k127_4037024_8	1123267.JONN01000001_gene909	1.932e-86	289.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria,2K0B3@204457|Sphingomonadales	204457|Sphingomonadales	S	DNA recombination protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HFD1_k127_4046420_5	1123267.JONN01000001_gene2157	3.536e-54	193.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2U9H5@28211|Alphaproteobacteria,2K2S3@204457|Sphingomonadales	204457|Sphingomonadales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HFD1_k127_4046420_1	1123267.JONN01000001_gene2159	1.731e-66	233.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria,2K3YB@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HFD1_k127_4046420_0	392499.Swit_2828	1.486e-100	332.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria,2K06H@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HFD1_k127_4046420_2	745310.G432_10240	7.366e-64	224.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,2K2CA@204457|Sphingomonadales	204457|Sphingomonadales	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	-	-	-	-	-	-	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HFD1_k127_4046420_4	1123267.JONN01000001_gene2162	7.627e-59	209.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,2K6E5@204457|Sphingomonadales	204457|Sphingomonadales	G	PTS IIA-like nitrogen-regulatory protein PtsN	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HFD1_k127_4046420_6	1346791.M529_17075	3.053e-17	91.0	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UFES@28211|Alphaproteobacteria,2K70S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1491)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1491
HFD1_k127_4046420_3	1123267.JONN01000001_gene2165	2.914e-59	213.0	COG3773@1|root,COG3773@2|Bacteria,1RDSV@1224|Proteobacteria,2U8XY@28211|Alphaproteobacteria,2K4PG@204457|Sphingomonadales	204457|Sphingomonadales	M	COG3773 Cell wall hydrolyses involved in spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
HFD1_k127_4046420_7	745310.G432_10260	1.572e-11	74.0	COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,2K5GG@204457|Sphingomonadales	204457|Sphingomonadales	S	DNA repair protein MmcB-like	-	-	-	-	-	-	-	-	-	-	-	-	MmcB-like
HFD1_k127_4052933_3	1545915.JROG01000004_gene2391	1.978e-121	397.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2K0DX@204457|Sphingomonadales	204457|Sphingomonadales	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HFD1_k127_4052933_0	1292034.OR37_02259	2.466e-257	804.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria,2KEXX@204458|Caulobacterales	204458|Caulobacterales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_4052933_7	627192.SLG_02600	1.985e-63	219.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,2K4G2@204457|Sphingomonadales	204457|Sphingomonadales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HFD1_k127_4052933_5	1123267.JONN01000001_gene2309	1.047e-64	225.0	COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria,2K35H@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
HFD1_k127_4052933_1	1112214.AHIS01000009_gene153	1.14e-202	640.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2K0K7@204457|Sphingomonadales	204457|Sphingomonadales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HFD1_k127_4052933_8	1123267.JONN01000001_gene2379	1.111e-57	206.0	2BYSU@1|root,32R3U@2|Bacteria,1MZ0R@1224|Proteobacteria,2U9AE@28211|Alphaproteobacteria,2K44Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
HFD1_k127_4052933_6	1122218.KB893654_gene2301	1.414e-64	226.0	29CWT@1|root,2ZZUX@2|Bacteria,1REF2@1224|Proteobacteria,2U7K7@28211|Alphaproteobacteria,1JVD1@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2585)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2585
HFD1_k127_4052933_4	1123267.JONN01000001_gene2382	8.645e-115	379.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria,2K4ZK@204457|Sphingomonadales	204457|Sphingomonadales	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HFD1_k127_4052933_2	1123267.JONN01000001_gene2385	5.193e-157	504.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2K0CP@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HFD1_k127_4058816_1	194867.ALBQ01000023_gene3222	5.442e-273	842.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2K0YK@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HFD1_k127_4058816_18	1122612.AUBA01000008_gene2305	7.653e-94	328.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K26Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16
HFD1_k127_4058816_19	1229204.AMYY01000013_gene197	1.656e-87	308.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2TSZM@28211|Alphaproteobacteria,4BQIK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_4058816_35	1032480.MLP_00330	1.983e-17	94.0	2E3QV@1|root,32YNP@2|Bacteria,2GQQZ@201174|Actinobacteria,4DSDG@85009|Propionibacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
HFD1_k127_4058816_28	1038860.AXAP01000029_gene676	1.405e-45	171.0	COG3829@1|root,COG3920@1|root,COG3829@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U3NH@28211|Alphaproteobacteria,3K6NB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS,PAS_4
HFD1_k127_4058816_16	1123267.JONN01000001_gene1206	1.673e-102	340.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2TRE6@28211|Alphaproteobacteria,2K1CX@204457|Sphingomonadales	204457|Sphingomonadales	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HFD1_k127_4058816_33	1123267.JONN01000001_gene1208	3.249e-26	114.0	2DTUP@1|root,33MQD@2|Bacteria,1NPP7@1224|Proteobacteria,2UX90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
HFD1_k127_4058816_36	1123267.JONN01000001_gene1208	1.657e-16	83.0	2DTUP@1|root,33MQD@2|Bacteria,1NPP7@1224|Proteobacteria,2UX90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
HFD1_k127_4058816_21	317655.Sala_1282	1.264e-82	279.0	COG0288@1|root,COG0288@2|Bacteria,1MV1U@1224|Proteobacteria,2VEYE@28211|Alphaproteobacteria,2KDW2@204457|Sphingomonadales	204457|Sphingomonadales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HFD1_k127_4058816_8	1123267.JONN01000001_gene1209	2.184e-172	544.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,2K1H4@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HFD1_k127_4058816_22	1123267.JONN01000001_gene1210	2.433e-69	241.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,2K41W@204457|Sphingomonadales	204457|Sphingomonadales	I	Oligoketide cyclase lipid transport protein	-	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
HFD1_k127_4058816_32	1150469.RSPPHO_02919	1.138e-28	124.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria,2JSR4@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HFD1_k127_4058816_11	1123267.JONN01000001_gene1212	1.185e-136	445.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2K0Y0@204457|Sphingomonadales	204457|Sphingomonadales	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HFD1_k127_4058816_9	1123267.JONN01000001_gene1213	8.192e-170	545.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,2K0QH@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HFD1_k127_4058816_0	1123267.JONN01000001_gene1214	4.357e-306	954.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,2K01N@204457|Sphingomonadales	204457|Sphingomonadales	T	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HFD1_k127_4058816_4	1123267.JONN01000001_gene1215	2.741e-235	734.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,2K1KM@204457|Sphingomonadales	204457|Sphingomonadales	T	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_4058816_26	1123267.JONN01000001_gene1216	9.137e-55	196.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2UBTW@28211|Alphaproteobacteria,2K2YT@204457|Sphingomonadales	204457|Sphingomonadales	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HFD1_k127_4058816_7	1123267.JONN01000001_gene1217	3.573e-181	576.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2TUXJ@28211|Alphaproteobacteria,2K0SI@204457|Sphingomonadales	204457|Sphingomonadales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HFD1_k127_4058816_17	1123267.JONN01000002_gene365	1.485e-97	325.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2K0DA@204457|Sphingomonadales	204457|Sphingomonadales	S	MazG family	mazG	-	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
HFD1_k127_4058816_24	1123267.JONN01000002_gene364	2.458e-66	231.0	COG3577@1|root,COG3577@2|Bacteria,1R74B@1224|Proteobacteria,2UBEE@28211|Alphaproteobacteria,2K1P8@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
HFD1_k127_4058816_14	1123267.JONN01000002_gene361	1.009e-116	381.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,2K0X6@204457|Sphingomonadales	204457|Sphingomonadales	L	LuxR family transcriptional regulator	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HFD1_k127_4058816_2	392499.Swit_0486	5.401e-241	752.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,2K0VF@204457|Sphingomonadales	204457|Sphingomonadales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
HFD1_k127_4058816_15	1123267.JONN01000002_gene359	3.952e-107	357.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,2JZZA@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HFD1_k127_4058816_20	1123267.JONN01000002_gene358	1.785e-84	287.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,2K3VU@204457|Sphingomonadales	204457|Sphingomonadales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HFD1_k127_4058816_6	1123267.JONN01000002_gene357	5.681e-183	579.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,2K17Y@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S11 family	dac	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HFD1_k127_4058816_13	1123267.JONN01000002_gene356	1.58e-119	394.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,2K0TV@204457|Sphingomonadales	204457|Sphingomonadales	M	Lytic murein transglycosylase	mltB	-	-	-	-	-	-	-	-	-	-	-	SLT_2
HFD1_k127_4058816_37	1168059.KB899087_gene1061	5.541e-14	75.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3F0VP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD1_k127_4058816_29	1123267.JONN01000001_gene730	1.45e-45	167.0	COG3682@1|root,COG3682@2|Bacteria,1N95N@1224|Proteobacteria,2UISP@28211|Alphaproteobacteria,2K5C7@204457|Sphingomonadales	204457|Sphingomonadales	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HFD1_k127_4058816_12	1123267.JONN01000001_gene729	3.728e-120	408.0	COG4219@1|root,COG4219@2|Bacteria,1N96C@1224|Proteobacteria,2UI6V@28211|Alphaproteobacteria,2K34J@204457|Sphingomonadales	204457|Sphingomonadales	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
HFD1_k127_4058816_25	1123267.JONN01000001_gene728	5.642e-62	226.0	COG4219@1|root,COG4219@2|Bacteria,1P0K4@1224|Proteobacteria,2UVBF@28211|Alphaproteobacteria,2K7R8@204457|Sphingomonadales	204457|Sphingomonadales	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4058816_3	1123267.JONN01000002_gene355	9.25e-240	762.0	COG1629@1|root,COG4771@2|Bacteria,1R0WC@1224|Proteobacteria,2U1A6@28211|Alphaproteobacteria,2KE9F@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_4058816_5	1123267.JONN01000002_gene354	1.982e-220	688.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria,2K030@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_4058816_23	392499.Swit_4520	2.685e-67	234.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,2K6NB@204457|Sphingomonadales	204457|Sphingomonadales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD1_k127_4058816_10	392499.Swit_4521	2.304e-166	543.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
HFD1_k127_4058816_30	1229485.AMYV01000013_gene385	2.547e-44	167.0	COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,1S42B@1236|Gammaproteobacteria,1J7E3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HFD1_k127_4058816_31	1123267.JONN01000001_gene1161	3.174e-37	142.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria,2K643@204457|Sphingomonadales	204457|Sphingomonadales	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HFD1_k127_4058816_27	945713.IALB_2304	5.497e-48	177.0	2CBKC@1|root,32RTJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4058816_34	1123267.JONN01000001_gene1160	5.805e-20	94.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2K12C@204457|Sphingomonadales	204457|Sphingomonadales	H	receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HFD1_k127_4062203_10	1248916.ANFY01000009_gene178	1.238e-27	113.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,2K260@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HFD1_k127_4062203_1	1123267.JONN01000002_gene132	1.851e-226	717.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2K0VR@204457|Sphingomonadales	204457|Sphingomonadales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
HFD1_k127_4062203_7	1123267.JONN01000002_gene134	3.772e-59	209.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,2K3W5@204457|Sphingomonadales	204457|Sphingomonadales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HFD1_k127_4062203_3	1123267.JONN01000002_gene135	1.486e-198	624.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,2K02X@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HFD1_k127_4062203_0	1123267.JONN01000002_gene136	0.0	1804.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,2JZX4@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HFD1_k127_4062203_5	1123267.JONN01000002_gene137	1.418e-71	246.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2K439@204457|Sphingomonadales	204457|Sphingomonadales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HFD1_k127_4062203_6	1123267.JONN01000002_gene138	1.537e-70	245.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2K57C@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HFD1_k127_4062203_9	1030157.AFMP01000050_gene38	4.788e-29	118.0	COG0483@1|root,COG0483@2|Bacteria,1N7D7@1224|Proteobacteria,2UF6T@28211|Alphaproteobacteria,2K5WG@204457|Sphingomonadales	204457|Sphingomonadales	G	Domain of unknown function (DUF4170)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4170
HFD1_k127_4062203_14	745310.G432_13070	4.37e-07	59.0	2APHC@1|root,31EKB@2|Bacteria,1QBWH@1224|Proteobacteria,2VEF2@28211|Alphaproteobacteria,2K7RB@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
HFD1_k127_4062203_15	590998.Celf_3176	9.654e-07	59.0	2DMMR@1|root,32SHV@2|Bacteria,2IQA6@201174|Actinobacteria,4F1GY@85016|Cellulomonadaceae	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HFD1_k127_4062203_12	1123267.JONN01000002_gene144	2.827e-25	113.0	2EJM3@1|root,33DC0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4062203_2	1123267.JONN01000002_gene145	7.696e-212	670.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,2K00W@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HFD1_k127_4062203_8	1123267.JONN01000002_gene146	4.2e-35	136.0	COG2919@1|root,COG2919@2|Bacteria,1NGSW@1224|Proteobacteria,2UJYE@28211|Alphaproteobacteria,2K7B8@204457|Sphingomonadales	204457|Sphingomonadales	D	Septum formation initiator	-	-	-	-	-	-	-	-	-	-	-	-	DivIC
HFD1_k127_4062203_4	1123267.JONN01000002_gene147	1.402e-182	578.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,2K0VG@204457|Sphingomonadales	204457|Sphingomonadales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HFD1_k127_4062203_11	685778.AORL01000010_gene2726	3.972e-27	112.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,2K0EK@204457|Sphingomonadales	204457|Sphingomonadales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_4066822_9	1123267.JONN01000001_gene2150	6.192e-91	303.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,2K05A@204457|Sphingomonadales	204457|Sphingomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HFD1_k127_4066822_18	46429.BV95_03191	8.599e-51	186.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2U9T9@28211|Alphaproteobacteria,2K4N2@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HFD1_k127_4066822_5	1030157.AFMP01000004_gene2053	2.329e-124	403.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,2K02Z@204457|Sphingomonadales	204457|Sphingomonadales	D	Chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD1_k127_4066822_8	1123267.JONN01000001_gene2147	9.475e-101	341.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2K0RQ@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HFD1_k127_4066822_10	1030157.AFMP01000004_gene2055	1.468e-84	292.0	COG1466@1|root,COG1466@2|Bacteria,1N7AB@1224|Proteobacteria,2UHPM@28211|Alphaproteobacteria,2K0ER@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase III	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HFD1_k127_4066822_17	1550073.JROH01000008_gene1730	1.221e-52	196.0	COG5468@1|root,COG5468@2|Bacteria,1RKF8@1224|Proteobacteria,2UACI@28211|Alphaproteobacteria,2K4FJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Lipopolysaccharide-assembly	-	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
HFD1_k127_4066822_2	1123267.JONN01000001_gene2144	1.433e-209	656.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,2K0Q0@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HFD1_k127_4066822_1	1123267.JONN01000001_gene2144	1.441e-224	702.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,2K0Q0@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HFD1_k127_4066822_16	1123267.JONN01000001_gene2143	1.213e-57	203.0	2C2J5@1|root,315UG@2|Bacteria,1RHAH@1224|Proteobacteria,2U94W@28211|Alphaproteobacteria,2K4E5@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF3576)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3576
HFD1_k127_4066822_14	1123267.JONN01000001_gene2142	1.69e-60	218.0	2C7BT@1|root,33MZ9@2|Bacteria,1NMQ4@1224|Proteobacteria,2UG5B@28211|Alphaproteobacteria,2K40I@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HFD1_k127_4066822_20	1123269.NX02_25340	4.167e-14	81.0	COG0352@1|root,COG0352@2|Bacteria,1RKGX@1224|Proteobacteria,2UB4W@28211|Alphaproteobacteria,2K57F@204457|Sphingomonadales	204457|Sphingomonadales	H	Thiamine monophosphate synthase	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HFD1_k127_4066822_12	1123267.JONN01000001_gene2140	3.539e-76	261.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,2K0C6@204457|Sphingomonadales	204457|Sphingomonadales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HFD1_k127_4066822_11	1550073.JROH01000008_gene1737	2.378e-79	272.0	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2U0W3@28211|Alphaproteobacteria,2K05N@204457|Sphingomonadales	204457|Sphingomonadales	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HFD1_k127_4066822_6	1123267.JONN01000001_gene2139	4.778e-120	394.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2TR82@28211|Alphaproteobacteria,2K0DD@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
HFD1_k127_4066822_4	1123267.JONN01000001_gene2138	2.183e-141	451.0	COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria,2K09T@204457|Sphingomonadales	204457|Sphingomonadales	L	exodeoxyribonuclease III	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD1_k127_4066822_15	1123267.JONN01000001_gene2137	1.074e-57	208.0	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,2K43J@204457|Sphingomonadales	204457|Sphingomonadales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
HFD1_k127_4066822_0	392499.Swit_3663	1.289e-294	924.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,2K02P@204457|Sphingomonadales	204457|Sphingomonadales	D	DNA segregation ATPase FtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HFD1_k127_4066822_3	1112212.JH584235_gene2482	2.369e-149	482.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,2JZY3@204457|Sphingomonadales	204457|Sphingomonadales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HFD1_k127_4066822_13	1123267.JONN01000001_gene2208	4.086e-74	256.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,2K0QK@204457|Sphingomonadales	204457|Sphingomonadales	S	to the N-terminal domain of Lon protease	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HFD1_k127_4066822_7	1174684.EBMC1_11280	3.349e-107	355.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,2K0HB@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_15,TPR_19,TPR_20,Thioredoxin
HFD1_k127_4066822_19	1123267.JONN01000001_gene1220	5.539e-38	146.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2K0Q5@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1012 NAD-dependent aldehyde dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HFD1_k127_4071717_0	158500.BV97_04396	1.604e-70	245.0	COG0265@1|root,COG0265@2|Bacteria,1R55B@1224|Proteobacteria,2U3H7@28211|Alphaproteobacteria,2K0CF@204457|Sphingomonadales	2|Bacteria	O	Trypsin-like peptidase domain	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HFD1_k127_4071717_2	1211115.ALIQ01000168_gene4006	7.735e-24	104.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3NBHU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD1_k127_4071717_3	1379701.JPJC01000095_gene2323	9.893e-06	50.0	2AMEG@1|root,31C9X@2|Bacteria,1Q8AQ@1224|Proteobacteria,2VEGR@28211|Alphaproteobacteria,2K7UN@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4071717_1	1331060.RLDS_00660	1.893e-42	158.0	2E9ZW@1|root,33G1Y@2|Bacteria,1NHJW@1224|Proteobacteria,2V9KJ@28211|Alphaproteobacteria,2K5D6@204457|Sphingomonadales	204457|Sphingomonadales	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
HFD1_k127_4075312_3	1174684.EBMC1_01515	1.167e-29	127.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2U1KM@28211|Alphaproteobacteria,2K0PB@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HFD1_k127_4075312_1	1123267.JONN01000001_gene1071	1.235e-62	220.0	2C0PI@1|root,32VVI@2|Bacteria,1N1H7@1224|Proteobacteria,2UE1P@28211|Alphaproteobacteria,2K60G@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4075312_0	383381.EH30_05855	1.998e-196	618.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,2K11C@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HFD1_k127_4075312_2	1123267.JONN01000001_gene1069	5.991e-38	143.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,2K0MC@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP-dependent DNA helicase RecG	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HFD1_k127_4075656_0	1123267.JONN01000001_gene1052	5.239e-273	858.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,2K08R@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7
HFD1_k127_4075656_1	1123267.JONN01000001_gene1053	5.205e-50	186.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2UBQ9@28211|Alphaproteobacteria,2K5A7@204457|Sphingomonadales	204457|Sphingomonadales	S	ATPase or kinase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HFD1_k127_4090679_1	194867.ALBQ01000011_gene186	4.754e-76	263.0	COG3233@1|root,COG3233@2|Bacteria,1NEVW@1224|Proteobacteria,2UKF4@28211|Alphaproteobacteria,2K049@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
HFD1_k127_4090679_0	194867.ALBQ01000011_gene187	1.391e-136	447.0	COG0438@1|root,COG0438@2|Bacteria,1NQJQ@1224|Proteobacteria,2UP7A@28211|Alphaproteobacteria,2KDUU@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyltransferase Family 4	-	-	-	ko:K14335	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HFD1_k127_4090679_2	1123267.JONN01000001_gene885	1.717e-28	118.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,2K1SR@204457|Sphingomonadales	204457|Sphingomonadales	J	Polynucleotide adenylyltransferase	cca	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
HFD1_k127_4105988_6	1123267.JONN01000001_gene2157	9.6e-16	80.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2U9H5@28211|Alphaproteobacteria,2K2S3@204457|Sphingomonadales	204457|Sphingomonadales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HFD1_k127_4105988_1	1123269.NX02_25420	1.782e-158	506.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,2JZZP@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HFD1_k127_4105988_5	1174684.EBMC1_06099	4.17e-62	218.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,2K4J9@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
HFD1_k127_4105988_0	1123267.JONN01000001_gene2154	3.997e-248	769.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,2K1UD@204457|Sphingomonadales	204457|Sphingomonadales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HFD1_k127_4105988_4	1123267.JONN01000001_gene2153	1.288e-74	256.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,2K1SQ@204457|Sphingomonadales	204457|Sphingomonadales	P	membrane protein, TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HFD1_k127_4105988_3	1502850.FG91_01793	5.335e-89	298.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,2K1SQ@204457|Sphingomonadales	204457|Sphingomonadales	P	membrane protein, TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HFD1_k127_4105988_2	452662.SJA_C1-00300	7.991e-126	415.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,2K0HT@204457|Sphingomonadales	204457|Sphingomonadales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HFD1_k127_4113641_1	1123267.JONN01000001_gene904	1.586e-46	172.0	COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,2U5TK@28211|Alphaproteobacteria,2K3A3@204457|Sphingomonadales	204457|Sphingomonadales	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HFD1_k127_4113641_0	1123267.JONN01000001_gene906	2.242e-170	544.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,2K1IB@204457|Sphingomonadales	204457|Sphingomonadales	M	synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HFD1_k127_4115303_1	1123267.JONN01000001_gene1141	3.466e-103	337.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,2K0C2@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HFD1_k127_4115303_0	685778.AORL01000021_gene838	2.974e-236	741.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HFD1_k127_4116216_4	1123267.JONN01000001_gene1815	1.372e-25	110.0	COG1426@1|root,COG1426@2|Bacteria,1ND8D@1224|Proteobacteria,2UB49@28211|Alphaproteobacteria,2K57P@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
HFD1_k127_4116216_0	1123267.JONN01000001_gene1816	0.0	1137.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,2K17Q@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HFD1_k127_4116216_2	1123267.JONN01000001_gene1818	1.087e-173	550.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2K0DQ@204457|Sphingomonadales	204457|Sphingomonadales	S	2-nitropropane dioxygenase	-	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO,ThiG
HFD1_k127_4116216_1	1123267.JONN01000001_gene1819	1.471e-207	652.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,2K044@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HFD1_k127_4116216_3	1331060.RLDS_16190	6.324e-88	295.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,2K0DH@204457|Sphingomonadales	204457|Sphingomonadales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HFD1_k127_4139515_5	1123267.JONN01000001_gene2037	5.385e-29	120.0	COG3595@1|root,COG3595@2|Bacteria,1N374@1224|Proteobacteria,2UDAB@28211|Alphaproteobacteria,2K1A2@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HFD1_k127_4139515_4	1123267.JONN01000001_gene2036	9.062e-95	314.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,2K0TA@204457|Sphingomonadales	204457|Sphingomonadales	K	CarD family transcriptional regulator	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HFD1_k127_4139515_1	1123267.JONN01000001_gene2035	2.269e-157	504.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,2K1Q4@204457|Sphingomonadales	204457|Sphingomonadales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HFD1_k127_4139515_0	1123267.JONN01000001_gene2034	3.157e-212	664.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2K12N@204457|Sphingomonadales	204457|Sphingomonadales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HFD1_k127_4139515_2	1537715.JQFJ01000002_gene1723	8.443e-122	394.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2K0GH@204457|Sphingomonadales	204457|Sphingomonadales	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HFD1_k127_4139515_3	1219049.SP5_043_00960	4.385e-102	343.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2K1AU@204457|Sphingomonadales	204457|Sphingomonadales	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD1_k127_4231701_2	1549858.MC45_12770	6.091e-38	146.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,2U0RR@28211|Alphaproteobacteria,2K0B9@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HFD1_k127_4231701_0	1123267.JONN01000001_gene1411	1.098e-117	381.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria,2K0KZ@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HFD1_k127_4231701_1	1123267.JONN01000001_gene1408	1.84e-98	325.0	COG0565@1|root,COG2827@1|root,COG0565@2|Bacteria,COG2827@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,2JZUG@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GIY-YIG,SpoU_methylase
HFD1_k127_4261311_6	864069.MicloDRAFT_00069530	4.829e-74	254.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,1JY94@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
HFD1_k127_4261311_2	702113.PP1Y_AT28375	1.022e-90	306.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2U6BE@28211|Alphaproteobacteria,2K4NC@204457|Sphingomonadales	204457|Sphingomonadales	S	enzyme related to lactoylglutathione lyase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_4261311_5	685778.AORL01000015_gene2449	1.053e-77	268.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria,2K5JQ@204457|Sphingomonadales	204457|Sphingomonadales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HFD1_k127_4261311_9	1041138.KB890233_gene1819	5.4e-59	212.0	COG0262@1|root,COG0262@2|Bacteria,1R5UU@1224|Proteobacteria,2U45H@28211|Alphaproteobacteria,4B988@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HFD1_k127_4261311_4	977880.RALTA_B2240	2.046e-82	279.0	COG0625@1|root,COG0625@2|Bacteria,1PENB@1224|Proteobacteria,2VNUW@28216|Betaproteobacteria,1K3Z4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HFD1_k127_4261311_7	1123267.JONN01000001_gene2003	4.638e-73	250.0	COG2214@1|root,COG2214@2|Bacteria,1MXTG@1224|Proteobacteria,2TRZH@28211|Alphaproteobacteria,2K4VC@204457|Sphingomonadales	204457|Sphingomonadales	O	molecular chaperone	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HFD1_k127_4261311_10	1123267.JONN01000001_gene2002	9.029e-31	126.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,2K60E@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
HFD1_k127_4261311_1	317655.Sala_0649	1.375e-130	428.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria,2K10E@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HFD1_k127_4261311_8	627192.SLG_35190	4.091e-67	231.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria,2K4I2@204457|Sphingomonadales	204457|Sphingomonadales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HFD1_k127_4261311_3	1174684.EBMC1_01470	7.092e-83	287.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,2K0EU@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD1_k127_4261311_0	1123269.NX02_21760	8.659e-272	848.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,2K0XA@204457|Sphingomonadales	204457|Sphingomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HFD1_k127_4270766_1	392499.Swit_2680	2.896e-101	336.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,2K06P@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
HFD1_k127_4270766_0	1123267.JONN01000001_gene1058	3.035e-320	1014.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,2K07I@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HFD1_k127_4294616_0	398525.KB900701_gene2099	3.641e-195	623.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,3JT7K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
HFD1_k127_4294616_1	398525.KB900701_gene2100	2.75e-47	178.0	COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,2U7MB@28211|Alphaproteobacteria,3K00J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
HFD1_k127_4294616_2	1197906.CAJQ02000059_gene510	2.199e-14	79.0	COG2963@1|root,COG2963@2|Bacteria,1RG98@1224|Proteobacteria,2U8JT@28211|Alphaproteobacteria,3JYQF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HFD1_k127_430070_4	745310.G432_12055	1.406e-20	93.0	2DMKE@1|root,32S6E@2|Bacteria,1NH3D@1224|Proteobacteria,2UHAS@28211|Alphaproteobacteria,2K72S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3572
HFD1_k127_430070_2	1123267.JONN01000001_gene2253	6.119e-45	167.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,2K53C@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD1_k127_430070_3	1331060.RLDS_12675	1.594e-25	106.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2UF4D@28211|Alphaproteobacteria,2K6VC@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HFD1_k127_430070_1	1120705.FG95_02717	3.496e-80	276.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2TVHN@28211|Alphaproteobacteria,2K3YY@204457|Sphingomonadales	204457|Sphingomonadales	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HFD1_k127_430070_0	1123267.JONN01000001_gene2256	2.168e-132	426.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,2K08Z@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP-dependent DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HFD1_k127_4315786_1	1123267.JONN01000002_gene93	1.739e-251	787.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2KEG2@204457|Sphingomonadales	204457|Sphingomonadales	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
HFD1_k127_4315786_0	1123267.JONN01000002_gene104	0.0	1135.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,2K0IA@204457|Sphingomonadales	204457|Sphingomonadales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HFD1_k127_4347864_1	365044.Pnap_0600	1.558e-16	85.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VM9Z@28216|Betaproteobacteria,4AC7U@80864|Comamonadaceae	28216|Betaproteobacteria	H	Dimethylmenaquinone methyltransferase	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HFD1_k127_4347864_0	257310.BB0677	7.821e-208	657.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,2VIBR@28216|Betaproteobacteria,3T3DW@506|Alcaligenaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_4357067_11	1239962.C943_00069	4.36e-12	72.0	2CG01@1|root,33W86@2|Bacteria,4P395@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4357067_8	1123267.JONN01000001_gene2445	1.473e-48	177.0	COG3791@1|root,COG3791@2|Bacteria,1N023@1224|Proteobacteria,2UC7M@28211|Alphaproteobacteria,2K6R3@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD1_k127_4357067_4	745310.G432_11970	1.495e-102	346.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2K0GT@204457|Sphingomonadales	204457|Sphingomonadales	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HFD1_k127_4357067_0	1123267.JONN01000001_gene2446	2.613e-186	587.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria,2K0Y3@204457|Sphingomonadales	204457|Sphingomonadales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HFD1_k127_4357067_1	1123267.JONN01000001_gene2447	1.047e-141	459.0	COG2267@1|root,COG2267@2|Bacteria,1QDFI@1224|Proteobacteria,2U244@28211|Alphaproteobacteria,2K3CZ@204457|Sphingomonadales	204457|Sphingomonadales	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
HFD1_k127_4357067_7	1123267.JONN01000001_gene2450	1.636e-51	188.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,2K4JS@204457|Sphingomonadales	204457|Sphingomonadales	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HFD1_k127_4357067_3	1550073.JROH01000001_gene571	3.396e-124	412.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,2K1NT@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HFD1_k127_4357067_10	685778.AORL01000025_gene115	2.42e-19	98.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,2K49Y@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HFD1_k127_4357067_9	1123267.JONN01000001_gene2456	1.574e-42	158.0	COG0790@1|root,COG0790@2|Bacteria,1N8SR@1224|Proteobacteria,2UFFQ@28211|Alphaproteobacteria,2K5VX@204457|Sphingomonadales	204457|Sphingomonadales	S	FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HFD1_k127_4357067_5	745310.G432_11140	9.794e-92	310.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2K0S2@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HFD1_k127_4357067_2	1123267.JONN01000001_gene2458	1.654e-125	410.0	COG1192@1|root,COG1192@2|Bacteria,1MVKR@1224|Proteobacteria,2TRZY@28211|Alphaproteobacteria,2K06A@204457|Sphingomonadales	204457|Sphingomonadales	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MipZ
HFD1_k127_4357067_6	1123267.JONN01000001_gene2459	1.091e-56	200.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,2K0Q1@204457|Sphingomonadales	204457|Sphingomonadales	G	phosphomannomutase	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HFD1_k127_4360847_0	1123267.JONN01000001_gene1406	1.503e-213	665.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,2K0BB@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HFD1_k127_4360847_1	452662.SJA_C1-21800	9.263e-62	218.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria,2K3W4@204457|Sphingomonadales	204457|Sphingomonadales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HFD1_k127_4360847_2	1123267.JONN01000001_gene1408	3.1e-24	102.0	COG0565@1|root,COG2827@1|root,COG0565@2|Bacteria,COG2827@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,2JZUG@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GIY-YIG,SpoU_methylase
HFD1_k127_4412001_4	1123267.JONN01000001_gene1702	4.61e-35	136.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,2K3ZK@204457|Sphingomonadales	204457|Sphingomonadales	O	Protein-disulfide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
HFD1_k127_4412001_1	1112214.AHIS01000077_gene3809	9.309e-153	495.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TRNM@28211|Alphaproteobacteria,2K3P4@204457|Sphingomonadales	204457|Sphingomonadales	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HFD1_k127_4412001_2	1123267.JONN01000001_gene1709	2.091e-104	349.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,2K02A@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HFD1_k127_4412001_0	1123267.JONN01000001_gene1710	4.765e-159	509.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,2K1HK@204457|Sphingomonadales	204457|Sphingomonadales	FP	exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HFD1_k127_4412001_3	1379701.JPJC01000255_gene1734	2.575e-81	274.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2K01R@204457|Sphingomonadales	204457|Sphingomonadales	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HFD1_k127_4449196_1	685778.AORL01000004_gene3475	8.705e-197	623.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_4449196_0	745310.G432_02550	2.522e-293	915.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria,2K0PD@204457|Sphingomonadales	204457|Sphingomonadales	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_4449196_3	1449049.JONW01000005_gene1121	7.644e-58	213.0	COG4313@1|root,COG4313@2|Bacteria,1N5CH@1224|Proteobacteria,2UDDM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HFD1_k127_4449196_6	228410.NE2151	4.854e-18	94.0	COG4244@1|root,COG4244@2|Bacteria,1NJGN@1224|Proteobacteria,2VYSI@28216|Betaproteobacteria,37354@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD1_k127_4449196_5	666685.R2APBS1_1800	2.67e-31	126.0	2ECSH@1|root,32CA7@2|Bacteria,1PW3Z@1224|Proteobacteria,1RW51@1236|Gammaproteobacteria,1X831@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4449196_4	237609.PSAKL28_29550	2.045e-32	134.0	COG2345@1|root,COG2345@2|Bacteria,1QTHM@1224|Proteobacteria,1S8I7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,MarR_2
HFD1_k127_4449196_2	1123267.JONN01000002_gene161	3.589e-135	433.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2K0MN@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD1_k127_4483091_1	392499.Swit_3856	5.796e-137	447.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria,2KEAE@204457|Sphingomonadales	204457|Sphingomonadales	EGP	of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_4483091_0	1123267.JONN01000001_gene2222	1.198e-151	488.0	COG0520@1|root,COG0520@2|Bacteria,1Q7AQ@1224|Proteobacteria,2VCMD@28211|Alphaproteobacteria,2K2Q9@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HFD1_k127_4596949_0	351348.Maqu_0982	3.566e-117	391.0	COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,1T44C@1236|Gammaproteobacteria,46D6Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HFD1_k127_4596949_1	504728.K649_07410	6.994e-16	80.0	COG1203@1|root,COG1203@2|Bacteria,1WIUC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM CRISPR-associated protein Cse1 (CRISPR_cse1)	-	-	-	ko:K19123	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cse1
HFD1_k127_4597560_1	1123267.JONN01000001_gene674	2.384e-95	319.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2E1@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD1_k127_4597560_2	1120705.FG95_01961	8.63e-65	224.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,2K42I@204457|Sphingomonadales	204457|Sphingomonadales	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD1_k127_4597560_0	1123267.JONN01000001_gene676	1.648e-308	953.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,2K18V@204457|Sphingomonadales	204457|Sphingomonadales	C	Transketolase, thiamine diphosphate binding domain	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N
HFD1_k127_4678765_6	698769.JFBD01000042_gene814	9.003e-06	53.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_4678765_0	1336243.JAEA01000012_gene3006	3.796e-197	629.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,1JRDR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_4678765_1	1123267.JONN01000001_gene2205	3.055e-130	426.0	COG2367@1|root,COG2367@2|Bacteria,1PNSR@1224|Proteobacteria,2U483@28211|Alphaproteobacteria,2K1SY@204457|Sphingomonadales	204457|Sphingomonadales	V	beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,Peptidase_S13
HFD1_k127_4678765_4	1123267.JONN01000001_gene2204	4.462e-75	261.0	291EX@1|root,2ZP1S@2|Bacteria,1RF3T@1224|Proteobacteria,2U83Z@28211|Alphaproteobacteria,2K4S8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mitofilin
HFD1_k127_4678765_5	1123267.JONN01000001_gene2203	7.088e-50	186.0	COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2UMED@28211|Alphaproteobacteria,2K52Q@204457|Sphingomonadales	204457|Sphingomonadales	H	Uroporphyrinogen-III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HFD1_k127_4678765_3	685778.AORL01000022_gene1646	1.224e-95	321.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,2K19Y@204457|Sphingomonadales	204457|Sphingomonadales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HFD1_k127_4678765_2	1123267.JONN01000001_gene2201	2.16e-103	342.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,2K0S9@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HFD1_k127_4684532_0	318586.Pden_3281	5.169e-195	621.0	COG3464@1|root,COG3464@2|Bacteria,1N2KA@1224|Proteobacteria,2TVCT@28211|Alphaproteobacteria,2PZ1B@265|Paracoccus	28211|Alphaproteobacteria	L	PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein	MA20_12025	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
HFD1_k127_4684532_1	595536.ADVE02000001_gene1307	4.05e-10	62.0	COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria,36ZBE@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,HTH_32,HTH_33
HFD1_k127_4700924_1	1123267.JONN01000001_gene2250	3.093e-103	341.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TR5S@28211|Alphaproteobacteria,2K1R4@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.276	ko:K05886	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
HFD1_k127_4700924_2	1123267.JONN01000001_gene2249	2.069e-65	227.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,2K4U7@204457|Sphingomonadales	204457|Sphingomonadales	J	endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HFD1_k127_4700924_0	1123267.JONN01000001_gene2247	7.351e-118	385.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,2K1NQ@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HFD1_k127_471250_3	1120705.FG95_03857	5.337e-40	151.0	2C3PP@1|root,2Z954@2|Bacteria,1MXGR@1224|Proteobacteria,2TS01@28211|Alphaproteobacteria,2K2TC@204457|Sphingomonadales	204457|Sphingomonadales	S	Branched-chain amino acid aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_471250_1	1038859.AXAU01000013_gene6505	2.408e-46	173.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2U971@28211|Alphaproteobacteria,3K64H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HFD1_k127_471250_4	1454010.JEOE01000026_gene1332	1.173e-09	66.0	COG3247@1|root,COG3247@2|Bacteria,2GP9Y@201174|Actinobacteria	201174|Actinobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HFD1_k127_471250_0	1030157.AFMP01000051_gene343	1.178e-74	253.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,2K3W8@204457|Sphingomonadales	204457|Sphingomonadales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HFD1_k127_471250_2	1007104.SUS17_2964	2.327e-40	150.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,2K0I9@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HFD1_k127_4848363_0	1123267.JONN01000001_gene1398	0.0	1134.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,2K2HN@204457|Sphingomonadales	204457|Sphingomonadales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
HFD1_k127_4848363_4	392499.Swit_4879	9.754e-71	242.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2K4E7@204457|Sphingomonadales	204457|Sphingomonadales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HFD1_k127_4848363_1	1123267.JONN01000001_gene1397	3.094e-101	338.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2K1F9@204457|Sphingomonadales	204457|Sphingomonadales	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HFD1_k127_4848363_2	1123267.JONN01000001_gene1395	4.796e-85	288.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,2K0N6@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HFD1_k127_4848363_3	1123267.JONN01000001_gene1395	2.748e-76	259.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,2K0N6@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HFD1_k127_4848363_5	1040989.AWZU01000004_gene7062	2.23e-33	131.0	COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria,3K009@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2,Cupin_7,DUF4437
HFD1_k127_4868627_2	1123267.JONN01000001_gene466	2.588e-17	81.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,2K0PF@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HFD1_k127_4868627_0	1123267.JONN01000001_gene1627	0.0	2542.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,2K1CM@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HFD1_k127_4868627_1	1123267.JONN01000001_gene1626	8.411e-235	731.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JZWE@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HFD1_k127_4893032_9	1123267.JONN01000001_gene449	2.155e-36	140.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,2K0W3@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HFD1_k127_4893032_8	1090320.KB900605_gene1875	1.324e-140	453.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,2K0QA@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HFD1_k127_4893032_0	1123267.JONN01000001_gene447	1.382e-231	725.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,2K03S@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_4893032_7	1123267.JONN01000001_gene446	2.377e-161	535.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,2K0YF@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HFD1_k127_4893032_3	1123267.JONN01000001_gene445	2.366e-184	585.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,2K0IS@204457|Sphingomonadales	204457|Sphingomonadales	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HFD1_k127_4893032_5	46429.BV95_00357	8.085e-168	542.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,2K1GM@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HFD1_k127_4893032_2	1123267.JONN01000001_gene443	2.304e-192	605.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,2K18Y@204457|Sphingomonadales	204457|Sphingomonadales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HFD1_k127_4893032_6	1346791.M529_13470	1.538e-167	539.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,2K1N2@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_4893032_1	1123267.JONN01000001_gene441	8.988e-217	684.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,2K12F@204457|Sphingomonadales	204457|Sphingomonadales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_4893032_4	745310.G432_05580	2.994e-171	544.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,2K0Y2@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell division protein FtsI penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HFD1_k127_4909723_4	745310.G432_14290	1.766e-45	169.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,2K1F2@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD1_k127_4909723_0	1123267.JONN01000001_gene2350	1.137e-148	477.0	COG1092@1|root,COG1092@2|Bacteria,1QSD4@1224|Proteobacteria,2TUFT@28211|Alphaproteobacteria,2K037@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HFD1_k127_4909723_1	685778.AORL01000022_gene1374	1.241e-58	211.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,2K43Z@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HFD1_k127_4909723_2	1123267.JONN01000001_gene2352	6.704e-52	192.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,2K5BJ@204457|Sphingomonadales	204457|Sphingomonadales	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HFD1_k127_4909723_3	1123267.JONN01000001_gene2353	2.539e-49	179.0	COG3824@1|root,COG3824@2|Bacteria,1N18M@1224|Proteobacteria,2UBUK@28211|Alphaproteobacteria,2K6IY@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
HFD1_k127_4909723_6	392499.Swit_3384	9.089e-10	69.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales	204457|Sphingomonadales	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD1_k127_4909723_5	13690.CP98_00612	1.192e-14	74.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria,2K2E0@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
HFD1_k127_4913042_13	1123267.JONN01000001_gene1692	4.049e-25	106.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,2K1PD@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HFD1_k127_4913042_12	1123267.JONN01000001_gene1693	4.651e-31	125.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,2K60Q@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD1_k127_4913042_14	1123267.JONN01000001_gene1694	4.778e-21	96.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HFD1_k127_4913042_9	1123267.JONN01000001_gene1695	5.416e-87	293.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria,2K231@204457|Sphingomonadales	204457|Sphingomonadales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HFD1_k127_4913042_7	745310.G432_05485	2.785e-106	349.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria,2K15W@204457|Sphingomonadales	204457|Sphingomonadales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HFD1_k127_4913042_5	1123267.JONN01000001_gene1697	1.858e-129	421.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria,2JZUV@204457|Sphingomonadales	204457|Sphingomonadales	G	beta-N-acetylhexosaminidase	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HFD1_k127_4913042_10	1123267.JONN01000001_gene1698	4.284e-65	237.0	COG3115@1|root,COG3115@2|Bacteria,1RJNQ@1224|Proteobacteria,2UC30@28211|Alphaproteobacteria,2K2NX@204457|Sphingomonadales	204457|Sphingomonadales	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HFD1_k127_4913042_0	1123267.JONN01000001_gene1700	1.143e-281	874.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,2K0G5@204457|Sphingomonadales	204457|Sphingomonadales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1,tRNA-synt_1d,tRNA-synt_1f
HFD1_k127_4913042_3	1123267.JONN01000001_gene454	1.684e-173	551.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,2K0JG@204457|Sphingomonadales	204457|Sphingomonadales	F	dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HFD1_k127_4913042_11	1123267.JONN01000001_gene453	4.527e-64	235.0	COG0457@1|root,COG5010@1|root,COG0457@2|Bacteria,COG5010@2|Bacteria,1RDU3@1224|Proteobacteria,2U790@28211|Alphaproteobacteria,2KEAN@204457|Sphingomonadales	204457|Sphingomonadales	U	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_19
HFD1_k127_4913042_1	1123267.JONN01000001_gene452	9.051e-214	675.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,2K16V@204457|Sphingomonadales	204457|Sphingomonadales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HFD1_k127_4913042_6	1502850.FG91_01127	5.09e-115	383.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2UD2N@28211|Alphaproteobacteria,2KCXQ@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HFD1_k127_4913042_2	1123267.JONN01000001_gene451	3.075e-188	601.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,2K082@204457|Sphingomonadales	204457|Sphingomonadales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HFD1_k127_4913042_8	1123267.JONN01000001_gene450	1.351e-98	331.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,2K1JE@204457|Sphingomonadales	204457|Sphingomonadales	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HFD1_k127_4913042_4	1123267.JONN01000001_gene449	1.008e-140	449.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,2K0W3@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HFD1_k127_4938968_2	1537715.JQFJ01000002_gene1070	1.686e-105	347.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria,2K25Z@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HFD1_k127_4938968_3	1219035.NT2_01_01340	8.57e-72	245.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,2K3WY@204457|Sphingomonadales	204457|Sphingomonadales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HFD1_k127_4938968_4	1123267.JONN01000001_gene933	2.184e-59	208.0	COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria,2K5Y0@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase III	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HFD1_k127_4938968_0	1123267.JONN01000001_gene932	3.994e-203	644.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,2K04B@204457|Sphingomonadales	204457|Sphingomonadales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HFD1_k127_4938968_1	1123267.JONN01000001_gene931	3.992e-137	447.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,2K1GQ@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
HFD1_k127_4957479_0	69279.BG36_05495	1.813e-183	586.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,2TUN4@28211|Alphaproteobacteria,43J21@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HFD1_k127_4957479_1	1346791.M529_22510	8.838e-122	396.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria,2K1VV@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HFD1_k127_4957479_3	861299.J421_5872	1.787e-15	83.0	2DGQG@1|root,2ZWXW@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_4957479_4	1384049.CD29_15005	2.508e-13	75.0	2E6HR@1|root,33150@2|Bacteria,1VF6G@1239|Firmicutes,4IR8Y@91061|Bacilli	91061|Bacilli	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HFD1_k127_4957479_2	1081640.AGFU01000002_gene407	4.918e-58	202.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2K1AU@204457|Sphingomonadales	204457|Sphingomonadales	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HFD1_k127_5003035_7	1123269.NX02_05515	4.909e-57	200.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,2K2AP@204457|Sphingomonadales	204457|Sphingomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HFD1_k127_5003035_9	1411123.JQNH01000001_gene2870	7.72e-43	160.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HFD1_k127_5003035_3	1219035.NT2_02_05260	5.263e-101	330.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,2K19Z@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HFD1_k127_5003035_2	1123267.JONN01000002_gene112	1.284e-103	346.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,2JZWR@204457|Sphingomonadales	204457|Sphingomonadales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	-	-	-	-	-	-	-	-	-	-	-	-	IlvC,IlvN
HFD1_k127_5003035_1	161528.ED21_28918	2.343e-110	368.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,2K0WU@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HFD1_k127_5003035_4	1537715.JQFJ01000002_gene923	2.146e-84	289.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria,2K069@204457|Sphingomonadales	204457|Sphingomonadales	E	phosphoserine phosphatase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
HFD1_k127_5003035_5	1007104.SUS17_1903	1.382e-65	239.0	COG0790@1|root,COG3147@1|root,COG0790@2|Bacteria,COG3147@2|Bacteria,1RJ71@1224|Proteobacteria,2U15P@28211|Alphaproteobacteria,2K032@204457|Sphingomonadales	204457|Sphingomonadales	S	FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	SPOR,Sel1
HFD1_k127_5003035_0	685778.AORL01000021_gene864	9.163e-129	414.0	COG1192@1|root,COG1192@2|Bacteria,1MWH3@1224|Proteobacteria,2U100@28211|Alphaproteobacteria,2K0JR@204457|Sphingomonadales	204457|Sphingomonadales	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HFD1_k127_5003035_8	1123267.JONN01000002_gene117	2.251e-44	172.0	2BWQA@1|root,2ZWJK@2|Bacteria,1N8MW@1224|Proteobacteria,2UGCR@28211|Alphaproteobacteria,2K66S@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5003035_6	1123267.JONN01000002_gene118	2.107e-63	231.0	COG3147@1|root,COG5010@1|root,COG3147@2|Bacteria,COG5010@2|Bacteria,1RK9P@1224|Proteobacteria,2U5CI@28211|Alphaproteobacteria,2K119@204457|Sphingomonadales	204457|Sphingomonadales	U	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_16,TPR_19,TPR_4
HFD1_k127_5012563_5	1123267.JONN01000002_gene22	1.009e-73	248.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2TTC4@28211|Alphaproteobacteria,2K27K@204457|Sphingomonadales	204457|Sphingomonadales	S	Phenylacetic acid catabolic protein	-	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD1_k127_5012563_6	392499.Swit_0754	1.654e-48	174.0	COG3460@1|root,COG3460@2|Bacteria,1RHM5@1224|Proteobacteria,2U9HF@28211|Alphaproteobacteria,2K5PV@204457|Sphingomonadales	204457|Sphingomonadales	Q	Phenylacetic acid degradation B	-	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
HFD1_k127_5012563_3	1123267.JONN01000002_gene24	5.557e-109	358.0	COG3396@1|root,COG3396@2|Bacteria,1MVYQ@1224|Proteobacteria,2TRYF@28211|Alphaproteobacteria,2JZUF@204457|Sphingomonadales	204457|Sphingomonadales	S	Phenylacetic acid catabolic protein	-	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HFD1_k127_5012563_2	1123267.JONN01000002_gene25	1.763e-157	503.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2U0WY@28211|Alphaproteobacteria,2K3BZ@204457|Sphingomonadales	204457|Sphingomonadales	C	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523,ko:K02613	ko00360,ko00520,ko01120,map00360,map00520,map01120	-	R03391,R03392,R09838	RC00230,RC02690	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HFD1_k127_5012563_1	1123267.JONN01000002_gene26	2.671e-165	529.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2TS9C@28211|Alphaproteobacteria,2K0UV@204457|Sphingomonadales	204457|Sphingomonadales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_5012563_0	1123267.JONN01000002_gene27	0.0	1102.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2V929@28211|Alphaproteobacteria,2K9IC@204457|Sphingomonadales	204457|Sphingomonadales	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HFD1_k127_5012563_4	1123267.JONN01000002_gene29	4.13e-88	300.0	COG0508@1|root,COG0508@2|Bacteria,1R0J5@1224|Proteobacteria,2U28K@28211|Alphaproteobacteria,2K8XE@204457|Sphingomonadales	204457|Sphingomonadales	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_5085861_22	1123267.JONN01000001_gene2389	1.184e-57	207.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2TQXG@28211|Alphaproteobacteria,2K1GD@204457|Sphingomonadales	204457|Sphingomonadales	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
HFD1_k127_5085861_10	1123267.JONN01000001_gene512	8.695e-131	427.0	COG0673@1|root,COG0673@2|Bacteria,1MW0Q@1224|Proteobacteria,2TQR0@28211|Alphaproteobacteria,2K0NU@204457|Sphingomonadales	204457|Sphingomonadales	S	Galactose 1-dehydrogenase	-	-	1.1.1.48	ko:K00035	ko00052,ko01100,map00052,map01100	-	R01094,R01097	RC00161	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
HFD1_k127_5085861_18	1123267.JONN01000001_gene513	1.393e-78	268.0	COG0800@1|root,COG0800@2|Bacteria,1RD0T@1224|Proteobacteria,2U7AQ@28211|Alphaproteobacteria,2K1WJ@204457|Sphingomonadales	204457|Sphingomonadales	G	Aldolase	-	-	4.1.2.21	ko:K01631	ko00052,ko01100,map00052,map01100	M00552	R01064	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HFD1_k127_5085861_16	1123267.JONN01000001_gene514	4.849e-91	310.0	COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2TTG8@28211|Alphaproteobacteria,2K1K8@204457|Sphingomonadales	204457|Sphingomonadales	G	2-keto-3-deoxy-galactonokinase	dgoK	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
HFD1_k127_5085861_13	1123267.JONN01000001_gene515	2.647e-109	362.0	COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2TV5X@28211|Alphaproteobacteria,2K16R@204457|Sphingomonadales	204457|Sphingomonadales	G	Gluconolactonase	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
HFD1_k127_5085861_3	1123267.JONN01000001_gene516	2.924e-233	726.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TT4I@28211|Alphaproteobacteria,2K354@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
HFD1_k127_5085861_6	1123267.JONN01000001_gene517	5.095e-200	628.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,2KCTY@204457|Sphingomonadales	204457|Sphingomonadales	M	mandelate racemase muconate lactonizing	-	-	4.2.1.6,4.2.1.8,5.1.2.2	ko:K01684,ko:K01781,ko:K08323	ko00040,ko00052,ko00627,ko01100,ko01120,map00040,map00052,map00627,map01100,map01120	M00061,M00552	R03033,R03791,R04161,R05606	RC00543,RC00998	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HFD1_k127_5085861_25	1048339.KB913029_gene879	1.91e-44	164.0	COG3813@1|root,COG3813@2|Bacteria,2I06T@201174|Actinobacteria,4ESZX@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1272)	-	-	-	ko:K09984	-	-	-	-	ko00000	-	-	-	DUF1272
HFD1_k127_5085861_23	1030157.AFMP01000064_gene2201	3.033e-56	201.0	COG2151@1|root,COG2151@2|Bacteria,1RF3S@1224|Proteobacteria,2TRQW@28211|Alphaproteobacteria,2K4PD@204457|Sphingomonadales	204457|Sphingomonadales	L	Iron-sulfur cluster assembly protein	-	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
HFD1_k127_5085861_7	1123267.JONN01000001_gene2369	2.91e-193	609.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K04I@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HFD1_k127_5085861_9	1380394.JADL01000012_gene1023	4.979e-153	494.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2TRCC@28211|Alphaproteobacteria,2JQJ4@204441|Rhodospirillales	204441|Rhodospirillales	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
HFD1_k127_5085861_15	1300345.LF41_1120	5.049e-92	312.0	COG4313@1|root,COG4313@2|Bacteria,1MWCX@1224|Proteobacteria,1S4A1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG4313 Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HFD1_k127_5085861_26	745310.G432_14325	2.015e-26	115.0	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2UBWN@28211|Alphaproteobacteria,2K5VW@204457|Sphingomonadales	204457|Sphingomonadales	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HFD1_k127_5085861_29	1449076.JOOE01000001_gene2712	0.0003354	48.0	2DHGE@1|root,2ZZNG@2|Bacteria,1P6PN@1224|Proteobacteria,2UY72@28211|Alphaproteobacteria,2KBU8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HFD1_k127_5085861_17	1123267.JONN01000001_gene2373	1.652e-82	282.0	COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,2TU1E@28211|Alphaproteobacteria,2K01F@204457|Sphingomonadales	204457|Sphingomonadales	E	Phenylalanine-4-hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HFD1_k127_5085861_1	685778.AORL01000021_gene958	0.0	1067.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria,2KDD3@204457|Sphingomonadales	204457|Sphingomonadales	E	COG1505 Serine proteases of the peptidase family S9A	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD1_k127_5085861_21	317655.Sala_0890	3.471e-64	228.0	COG1853@1|root,COG2267@1|root,COG1853@2|Bacteria,COG2267@2|Bacteria,1RGYM@1224|Proteobacteria,2UCHI@28211|Alphaproteobacteria,2K5IK@204457|Sphingomonadales	204457|Sphingomonadales	I	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Flavin_Reduct
HFD1_k127_5085861_14	1007104.SUS17_395	7.681e-98	329.0	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2TU43@28211|Alphaproteobacteria,2K0C1@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
HFD1_k127_5085861_5	1123267.JONN01000001_gene2376	2.969e-202	638.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,2K0IX@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HFD1_k127_5085861_19	1123267.JONN01000001_gene2375	1.041e-74	261.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2TSQC@28211|Alphaproteobacteria,2K4XJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD1_k127_5085861_24	1300350.DSW25_03040	9.263e-51	188.0	COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2VACM@28211|Alphaproteobacteria,3ZX0C@60136|Sulfitobacter	28211|Alphaproteobacteria	S	SOS response	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5085861_8	1123267.JONN01000001_gene2313	1.443e-170	550.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,2JZYV@204457|Sphingomonadales	204457|Sphingomonadales	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HFD1_k127_5085861_0	1231392.OCGS_2484	0.0	1399.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HFD1_k127_5085861_27	69395.JQLZ01000007_gene1600	1.418e-22	102.0	COG4731@1|root,COG4731@2|Bacteria,1PZC6@1224|Proteobacteria,2VAFN@28211|Alphaproteobacteria,2KIX5@204458|Caulobacterales	204458|Caulobacterales	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HFD1_k127_5085861_28	1096546.WYO_3631	1.685e-11	70.0	COG4731@1|root,COG4731@2|Bacteria,1RHN9@1224|Proteobacteria,2U9SP@28211|Alphaproteobacteria,1JVV5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HFD1_k127_5085861_4	1123267.JONN01000001_gene2292	1.646e-221	709.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2TSPJ@28211|Alphaproteobacteria,2K1IZ@204457|Sphingomonadales	204457|Sphingomonadales	E	Histidine	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HFD1_k127_5085861_2	1123267.JONN01000001_gene2288	0.0	998.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,2K2BT@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HFD1_k127_5085861_11	1163409.UUA_04533	1.045e-127	420.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,1RMI9@1236|Gammaproteobacteria,1X31E@135614|Xanthomonadales	135614|Xanthomonadales	Q	Imidazolone-5-propionate hydrolase	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HFD1_k127_5085861_12	1123267.JONN01000001_gene2285	5.366e-118	386.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria,2K3CB@204457|Sphingomonadales	204457|Sphingomonadales	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HFD1_k127_5085861_20	1267535.KB906767_gene2439	1.882e-69	246.0	COG1914@1|root,COG1914@2|Bacteria,3Y751@57723|Acidobacteria	57723|Acidobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HFD1_k127_5110771_14	1443665.JACA01000012_gene1185	1.434e-73	258.0	28KF8@1|root,2ZA1G@2|Bacteria,4NK7X@976|Bacteroidetes,1I0C7@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5110771_0	1123267.JONN01000002_gene322	0.0	1358.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,2K28K@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HFD1_k127_5110771_18	69279.BG36_17875	1.855e-13	72.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2UBRG@28211|Alphaproteobacteria,43KTF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD1_k127_5110771_13	224911.27353464	6.006e-79	268.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria,3JYM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5110771_3	1007104.SUS17_1101	1.654e-225	713.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2K061@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HFD1_k127_5110771_2	1123267.JONN01000001_gene1183	3.681e-239	743.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,2K05F@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HFD1_k127_5110771_8	1123267.JONN01000001_gene1184	6.748e-110	360.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,2K019@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HFD1_k127_5110771_9	1174684.EBMC1_02685	8.912e-109	362.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,2K1B9@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
HFD1_k127_5110771_4	1123267.JONN01000001_gene1146	6.253e-141	451.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,2K0DP@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HFD1_k127_5110771_6	1123269.NX02_14370	1.423e-137	444.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,2JZY1@204457|Sphingomonadales	204457|Sphingomonadales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HFD1_k127_5110771_15	1545915.JROG01000004_gene1710	1.752e-73	263.0	COG2159@1|root,COG2159@2|Bacteria,1Q704@1224|Proteobacteria,2VD3Z@28211|Alphaproteobacteria,2K7IV@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HFD1_k127_5110771_19	1280954.HPO_00275	0.0002817	44.0	COG3710@1|root,COG5616@1|root,COG3710@2|Bacteria,COG5616@2|Bacteria,1PF3H@1224|Proteobacteria,2V7F9@28211|Alphaproteobacteria,43YSF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,Trans_reg_C
HFD1_k127_5110771_7	745310.G432_04280	3.751e-123	398.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria,2K1B1@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HFD1_k127_5110771_12	1123267.JONN01000001_gene1149	2.32e-88	294.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria,2K00Z@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HFD1_k127_5110771_10	1123267.JONN01000001_gene1150	1.422e-101	336.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,2K0JM@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HFD1_k127_5110771_16	1123267.JONN01000001_gene1151	1.189e-72	253.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2U9ED@28211|Alphaproteobacteria,2K1ET@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HFD1_k127_5110771_17	1123267.JONN01000001_gene1152	8.842e-37	143.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,2K0YA@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HFD1_k127_5110771_11	1335760.ASTG01000001_gene3032	1.225e-100	334.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,2K0YA@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HFD1_k127_5110771_5	1123267.JONN01000001_gene1153	1.269e-137	447.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,2K0AZ@204457|Sphingomonadales	204457|Sphingomonadales	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HFD1_k127_5110771_1	1123267.JONN01000001_gene1154	1.644e-313	975.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,2K0GI@204457|Sphingomonadales	204457|Sphingomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HFD1_k127_5129265_3	1123267.JONN01000001_gene1736	5.868e-42	157.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,2K2JH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,YkuD
HFD1_k127_5129265_5	392499.Swit_3430	2.148e-07	59.0	COG3798@1|root,COG3798@2|Bacteria,1N0BJ@1224|Proteobacteria,2UDJF@28211|Alphaproteobacteria,2KE5H@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
HFD1_k127_5129265_0	1379701.JPJC01000017_gene3293	2.291e-91	317.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,2K1K2@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HFD1_k127_5129265_1	1470591.BW41_02070	1.762e-89	304.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2K1RM@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_5129265_2	1123269.NX02_21010	1.318e-49	183.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U9GW@28211|Alphaproteobacteria,2K4I1@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD1_k127_5172896_0	1123267.JONN01000001_gene1092	3.566e-151	485.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,2K0YT@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
HFD1_k127_5172896_2	1449076.JOOE01000001_gene2474	2.844e-40	154.0	COG5331@1|root,COG5331@2|Bacteria,1N7DJ@1224|Proteobacteria,2U7D2@28211|Alphaproteobacteria,2KE6Y@204457|Sphingomonadales	204457|Sphingomonadales	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HFD1_k127_5172896_1	1123267.JONN01000001_gene1095	5.391e-150	476.0	COG1899@1|root,COG1899@2|Bacteria,1MVC6@1224|Proteobacteria,2TTRW@28211|Alphaproteobacteria,2K1R2@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HFD1_k127_5262111_3	1192759.AKIB01000107_gene328	6.523e-10	62.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,2K1MA@204457|Sphingomonadales	204457|Sphingomonadales	O	cytochrome C	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD1_k127_5262111_2	1123267.JONN01000001_gene1135	6.279e-50	181.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,2K56Y@204457|Sphingomonadales	204457|Sphingomonadales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HFD1_k127_5262111_1	1123267.JONN01000001_gene1133	3.26e-115	376.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,2K13J@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HFD1_k127_5262111_0	1123267.JONN01000001_gene1132	1.78e-151	489.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria,2K0AY@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HFD1_k127_5262111_4	1207055.C100_09280	2.141e-08	57.0	COG0537@1|root,COG0537@2|Bacteria,1N49J@1224|Proteobacteria,2U85A@28211|Alphaproteobacteria,2K4UB@204457|Sphingomonadales	204457|Sphingomonadales	FG	Histidine triad (HIT) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HFD1_k127_5284888_1	743721.Psesu_3038	2.205e-203	650.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMXI@1236|Gammaproteobacteria,1X3Q6@135614|Xanthomonadales	135614|Xanthomonadales	E	Dipeptidyl carboxypeptidase	dcp2	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HFD1_k127_5284888_0	1123269.NX02_23410	2.371e-259	813.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,2K16I@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD1_k127_5284888_2	1123267.JONN01000001_gene2174	8.883e-145	464.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,2TRDT@28211|Alphaproteobacteria,2K203@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HFD1_k127_5284888_5	1380356.JNIK01000017_gene2951	3.137e-46	171.0	COG5579@1|root,COG5579@2|Bacteria,2IM9J@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
HFD1_k127_5284888_4	1219035.NT2_02_00550	6.573e-54	194.0	COG1225@1|root,COG1225@2|Bacteria,1RHSM@1224|Proteobacteria,2U9FF@28211|Alphaproteobacteria,2K56N@204457|Sphingomonadales	204457|Sphingomonadales	O	Peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HFD1_k127_5284888_3	291985.CCSI01000003_gene234	5.562e-101	340.0	COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2U9RE@28211|Alphaproteobacteria,2K4GD@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,gag-asp_proteas
HFD1_k127_5288070_5	1030157.AFMP01000011_gene3757	4.037e-38	145.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,2K0IN@204457|Sphingomonadales	204457|Sphingomonadales	O	COG0694 Thioredoxin-like proteins and domains	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
HFD1_k127_5288070_4	1123267.JONN01000001_gene1312	2.914e-62	227.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2U9DR@28211|Alphaproteobacteria,2K5R6@204457|Sphingomonadales	204457|Sphingomonadales	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HFD1_k127_5288070_6	1123267.JONN01000001_gene1311	2.473e-26	115.0	COG3909@1|root,COG3909@2|Bacteria,1Q594@1224|Proteobacteria,2UG98@28211|Alphaproteobacteria,2K6Z1@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HFD1_k127_5288070_3	1123267.JONN01000001_gene1310	1.061e-124	406.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria,2K1F0@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HFD1_k127_5288070_2	1123267.JONN01000001_gene1309	9.209e-133	427.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,2K12I@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HFD1_k127_5288070_1	1123267.JONN01000001_gene1308	1.451e-155	497.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,2K1J0@204457|Sphingomonadales	204457|Sphingomonadales	I	enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
HFD1_k127_5288070_0	1123267.JONN01000001_gene1307	5.134e-159	503.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JZVG@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_5323882_0	1123267.JONN01000002_gene251	1.54e-139	467.0	COG2234@1|root,COG2234@2|Bacteria,1R56X@1224|Proteobacteria,2U2G7@28211|Alphaproteobacteria,2K2WC@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HFD1_k127_5323882_1	1123269.NX02_12995	2.11e-104	346.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,2K104@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD1_k127_5388112_1	1123267.JONN01000001_gene479	5.25e-75	261.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2K11D@204457|Sphingomonadales	204457|Sphingomonadales	CO	Thiol disulfide interchange protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbC,DsbD,Thioredoxin_7
HFD1_k127_5388112_0	1030157.AFMP01000044_gene1873	1.559e-281	874.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,2K0JK@204457|Sphingomonadales	204457|Sphingomonadales	E	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind
HFD1_k127_5393433_2	1123267.JONN01000001_gene1085	4.886e-06	48.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2U35U@28211|Alphaproteobacteria,2K136@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD1_k127_5393433_1	1123267.JONN01000001_gene1083	1.995e-181	572.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,2K118@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA repair photolyase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HFD1_k127_5393433_0	1123267.JONN01000001_gene1082	2.372e-200	633.0	COG2234@1|root,COG2234@2|Bacteria,1NE83@1224|Proteobacteria,2TSF8@28211|Alphaproteobacteria,2K0KQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HFD1_k127_542382_9	1123267.JONN01000001_gene1067	1.923e-44	163.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2K07V@204457|Sphingomonadales	204457|Sphingomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD1_k127_542382_5	1123267.JONN01000001_gene1065	9.642e-89	300.0	COG5001@1|root,COG5001@2|Bacteria,1QWUF@1224|Proteobacteria,2TX5E@28211|Alphaproteobacteria,2KEGM@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HFD1_k127_542382_4	1123267.JONN01000001_gene1064	1.484e-108	357.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,2K0E6@204457|Sphingomonadales	204457|Sphingomonadales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	ppnK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HFD1_k127_542382_7	56780.SYN_00659	3.532e-53	196.0	COG0834@1|root,COG1073@1|root,COG0834@2|Bacteria,COG1073@2|Bacteria,1N3ZN@1224|Proteobacteria,42VWV@68525|delta/epsilon subdivisions	1224|Proteobacteria	ET	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	dCache_1
HFD1_k127_542382_8	1123073.KB899241_gene3464	3.387e-46	184.0	COG0793@1|root,COG0793@2|Bacteria,1PW54@1224|Proteobacteria,1SXHB@1236|Gammaproteobacteria,1X8XJ@135614|Xanthomonadales	135614|Xanthomonadales	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_542382_1	1282362.AEAC466_13355	5.425e-182	585.0	COG2382@1|root,COG2382@2|Bacteria,1R6XH@1224|Proteobacteria,2U4UZ@28211|Alphaproteobacteria,2KHQX@204458|Caulobacterales	204458|Caulobacterales	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HFD1_k127_542382_6	1283300.ATXB01000001_gene1373	2.759e-62	226.0	COG4424@1|root,COG4424@2|Bacteria,1RGI6@1224|Proteobacteria,1S85X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
HFD1_k127_542382_3	1449049.JONW01000008_gene489	2.344e-131	436.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,2KH9Q@204458|Caulobacterales	204458|Caulobacterales	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HFD1_k127_542382_2	1449049.JONW01000008_gene490	6.767e-169	548.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG4618 ABC-type protease lipase transport system, ATPase and permease components	-	-	-	ko:K06148,ko:K12536,ko:K16299	ko02010,map02010	M00328,M00571	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1,3.A.1.110,3.A.1.110.10	-	-	ABC_membrane,ABC_tran
HFD1_k127_542382_0	383381.EH30_13320	9.017e-246	771.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2K1B6@204457|Sphingomonadales	204457|Sphingomonadales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HFD1_k127_5513245_0	1123267.JONN01000001_gene527	0.0	1095.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria,2K2GE@204457|Sphingomonadales	204457|Sphingomonadales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD1_k127_5513245_2	1123267.JONN01000001_gene528	3.272e-60	214.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria,2K489@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
HFD1_k127_5513245_1	1035191.HMPREF0185_01977	9.725e-89	310.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,2UH8N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HFD1_k127_5513245_3	1248916.ANFY01000004_gene1861	7.953e-23	98.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria,2KCTI@204457|Sphingomonadales	204457|Sphingomonadales	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HFD1_k127_5578638_4	1123267.JONN01000001_gene1355	4.698e-119	392.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2K0UZ@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the transketolase family	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD1_k127_5578638_14	1123267.JONN01000001_gene1357	4.226e-28	118.0	COG3027@1|root,COG3027@2|Bacteria,1Q3M7@1224|Proteobacteria,2VACI@28211|Alphaproteobacteria,2K78U@204457|Sphingomonadales	204457|Sphingomonadales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HFD1_k127_5578638_12	1123267.JONN01000001_gene1358	4.507e-41	160.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,2K6W9@204457|Sphingomonadales	204457|Sphingomonadales	H	5-formyltetrahydrofolate cyclo-ligase	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HFD1_k127_5578638_10	1502850.FG91_01707	2.958e-54	194.0	COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria,2U9AG@28211|Alphaproteobacteria,2K5BG@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HFD1_k127_5578638_16	317655.Sala_1323	5.264e-19	89.0	28WVU@1|root,2ZIV5@2|Bacteria,1NGX2@1224|Proteobacteria,2UJJ9@28211|Alphaproteobacteria,2K6RU@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2842
HFD1_k127_5578638_8	1123267.JONN01000001_gene1360	2.82e-83	289.0	COG3773@1|root,COG3773@2|Bacteria,1RE11@1224|Proteobacteria,2U89A@28211|Alphaproteobacteria,2K11T@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell Wall Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
HFD1_k127_5578638_18	1122169.AREN01000055_gene2006	3.198e-06	58.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	cbpA_1	-	-	ko:K03686,ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	CagE_TrbE_VirB,DUF87,DnaJ
HFD1_k127_5578638_1	1123267.JONN01000001_gene1361	3.202e-154	499.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria,2K11M@204457|Sphingomonadales	204457|Sphingomonadales	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HFD1_k127_5578638_5	1123267.JONN01000001_gene1364	8.598e-106	347.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,2K1A3@204457|Sphingomonadales	204457|Sphingomonadales	O	ATPase with chaperone activity	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HFD1_k127_5578638_2	1123267.JONN01000001_gene1364	3.959e-151	482.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,2K1A3@204457|Sphingomonadales	204457|Sphingomonadales	O	ATPase with chaperone activity	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HFD1_k127_5578638_15	1123267.JONN01000001_gene1365	1.343e-25	110.0	2A3CY@1|root,30RVE@2|Bacteria,1NNPQ@1224|Proteobacteria,2UJZN@28211|Alphaproteobacteria,2K7DT@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
HFD1_k127_5578638_11	314266.SKA58_14912	1.616e-49	180.0	COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2UFAB@28211|Alphaproteobacteria,2K5Y4@204457|Sphingomonadales	204457|Sphingomonadales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HFD1_k127_5578638_13	1502850.FG91_03331	7.47e-34	134.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2UFKH@28211|Alphaproteobacteria,2K625@204457|Sphingomonadales	204457|Sphingomonadales	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HFD1_k127_5578638_0	1123267.JONN01000001_gene1369	2.256e-211	670.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,2K1E1@204457|Sphingomonadales	204457|Sphingomonadales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HFD1_k127_5578638_7	745310.G432_15400	1.3e-87	306.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,2K0SN@204457|Sphingomonadales	204457|Sphingomonadales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HFD1_k127_5578638_6	745310.G432_15395	5.663e-98	325.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria,2K0C9@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_2,GST_N_3
HFD1_k127_5578638_9	555793.WSK_0159	1.944e-62	219.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,2U7QQ@28211|Alphaproteobacteria,2K4VJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_5578638_3	1123267.JONN01000001_gene1374	4.108e-145	466.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,2K0C3@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_5590566_0	314266.SKA58_03480	0.0	1145.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,2K00X@204457|Sphingomonadales	204457|Sphingomonadales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HFD1_k127_5590566_2	1219049.SP5_045_00060	1.982e-76	264.0	COG3751@1|root,COG3751@2|Bacteria,1RE5K@1224|Proteobacteria,2UDIR@28211|Alphaproteobacteria,2KE40@204457|Sphingomonadales	204457|Sphingomonadales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_4
HFD1_k127_5590566_1	237727.NAP1_00600	9.003e-90	303.0	COG3751@1|root,COG3751@2|Bacteria,1MYBU@1224|Proteobacteria,2UAT5@28211|Alphaproteobacteria,2K2VM@204457|Sphingomonadales	204457|Sphingomonadales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_4
HFD1_k127_5590566_3	1207055.C100_02545	3.883e-63	232.0	COG3063@1|root,COG3063@2|Bacteria,1QUNN@1224|Proteobacteria,2TW22@28211|Alphaproteobacteria,2KE93@204457|Sphingomonadales	204457|Sphingomonadales	NU	Putative 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5,TPR_16,TPR_19
HFD1_k127_5627102_0	1123267.JONN01000001_gene1200	0.0	1020.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,2K1R8@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HFD1_k127_5627102_4	1219049.SP5_005_00160	6.178e-104	342.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,2K04P@204457|Sphingomonadales	204457|Sphingomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HFD1_k127_5627102_2	1331060.RLDS_09770	2.036e-187	596.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,2K03V@204457|Sphingomonadales	204457|Sphingomonadales	M	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HFD1_k127_5627102_1	1123267.JONN01000001_gene1196	6.962e-239	743.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,2K181@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
HFD1_k127_5627102_3	1112212.JH584235_gene1643	4.395e-137	445.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,2K0WB@204457|Sphingomonadales	204457|Sphingomonadales	E	cystathionine beta-lyase	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HFD1_k127_5627102_7	1123267.JONN01000001_gene1145	5.798e-54	194.0	2E4J2@1|root,32ZE4@2|Bacteria,1RHJR@1224|Proteobacteria,2V5X3@28211|Alphaproteobacteria,2K5FN@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3775
HFD1_k127_5627102_6	1123267.JONN01000001_gene1144	2.632e-59	209.0	COG1514@1|root,COG1514@2|Bacteria,1RIHA@1224|Proteobacteria,2UAUZ@28211|Alphaproteobacteria,2K46A@204457|Sphingomonadales	204457|Sphingomonadales	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HFD1_k127_5627102_5	1123267.JONN01000001_gene1142	3.217e-78	263.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HFD1_k127_5628029_3	745310.G432_14290	9.282e-75	269.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,2K1F2@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HFD1_k127_5628029_6	685778.AORL01000022_gene1379	2.954e-51	188.0	COG3346@1|root,COG3346@2|Bacteria,1RIJQ@1224|Proteobacteria,2UA1G@28211|Alphaproteobacteria,2K34C@204457|Sphingomonadales	204457|Sphingomonadales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
HFD1_k127_5628029_7	1123267.JONN01000001_gene2347	1.461e-42	161.0	COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria,2K61Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HFD1_k127_5628029_1	685778.AORL01000022_gene1381	3.033e-135	434.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,2JZW3@204457|Sphingomonadales	204457|Sphingomonadales	C	Heme copper-type cytochrome quinol oxidase, subunit 3	ctaE	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HFD1_k127_5628029_4	1123267.JONN01000001_gene2345	3.165e-60	217.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,2K3WU@204457|Sphingomonadales	204457|Sphingomonadales	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HFD1_k127_5628029_2	1470591.BW41_00771	1.238e-130	422.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,2K01V@204457|Sphingomonadales	204457|Sphingomonadales	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HFD1_k127_5628029_5	983920.Y88_2371	2.98e-56	203.0	COG0652@1|root,COG0652@2|Bacteria,1RGF5@1224|Proteobacteria,2U7DS@28211|Alphaproteobacteria,2KCH6@204457|Sphingomonadales	204457|Sphingomonadales	M	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HFD1_k127_5628029_0	1449076.JOOE01000002_gene990	0.0	1219.0	COG0840@1|root,COG1511@1|root,COG3437@1|root,COG5002@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria,2KEIX@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Response_reg
HFD1_k127_5636023_3	1123267.JONN01000001_gene1682	1.141e-66	229.0	COG2050@1|root,COG2050@2|Bacteria,1MZPH@1224|Proteobacteria,2UDIQ@28211|Alphaproteobacteria,2K62E@204457|Sphingomonadales	204457|Sphingomonadales	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD1_k127_5636023_1	1123267.JONN01000001_gene1681	9.641e-162	523.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,2K2A7@204457|Sphingomonadales	204457|Sphingomonadales	S	AFG1 family ATPase	-	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
HFD1_k127_5636023_2	1123267.JONN01000001_gene1676	5.844e-160	517.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales	204457|Sphingomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD1_k127_5636023_0	1123267.JONN01000001_gene1677	1.297e-186	595.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales	204457|Sphingomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HFD1_k127_5636023_4	1415756.JQMY01000001_gene2189	2.381e-33	130.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2PE4U@252301|Oceanicola	28211|Alphaproteobacteria	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HFD1_k127_5653187_1	1123267.JONN01000001_gene662	1.309e-46	177.0	COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U1V9@28211|Alphaproteobacteria,2KEE4@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_5653187_0	1346791.M529_12505	6.109e-55	196.0	COG4253@1|root,COG4253@2|Bacteria,1RFXU@1224|Proteobacteria,2US4C@28211|Alphaproteobacteria,2KDWZ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5653187_2	1007104.SUS17_104	1.9e-36	138.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2UBWW@28211|Alphaproteobacteria,2K5X6@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HFD1_k127_5667233_0	1123267.JONN01000001_gene1270	2.921e-220	694.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,2K1F3@204457|Sphingomonadales	204457|Sphingomonadales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
HFD1_k127_5667233_1	194867.ALBQ01000011_gene248	7.338e-134	437.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TSHB@28211|Alphaproteobacteria,2KD59@204457|Sphingomonadales	204457|Sphingomonadales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HFD1_k127_5667233_2	1030157.AFMP01000008_gene3249	1.138e-72	248.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TUM5@28211|Alphaproteobacteria,2K1MY@204457|Sphingomonadales	204457|Sphingomonadales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD1_k127_5683112_6	1550073.JROH01000001_gene652	1.647e-24	104.0	2AK5K@1|root,31AVG@2|Bacteria,1REG7@1224|Proteobacteria,2U8E6@28211|Alphaproteobacteria,2K5AP@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	-
HFD1_k127_5683112_3	348824.LPU83_3303	1.426e-74	257.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U5Q0@28211|Alphaproteobacteria,4BCA3@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HFD1_k127_5683112_2	1112216.JH594425_gene2849	4.371e-110	374.0	2E384@1|root,32Y7U@2|Bacteria,1N36R@1224|Proteobacteria,2UW56@28211|Alphaproteobacteria,2K1PQ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	ko:K18546	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	-
HFD1_k127_5683112_5	471852.Tcur_4486	1.507e-59	208.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4EJCJ@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
HFD1_k127_5683112_7	745310.G432_15455	1.032e-15	83.0	COG1983@1|root,COG1983@2|Bacteria,1NK8Q@1224|Proteobacteria,2UNBI@28211|Alphaproteobacteria,2K844@204457|Sphingomonadales	204457|Sphingomonadales	KT	PspC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PspC
HFD1_k127_5683112_4	1123267.JONN01000002_gene343	9.21e-68	237.0	29636@1|root,2ZTDK@2|Bacteria,1RFN7@1224|Proteobacteria,2U8TB@28211|Alphaproteobacteria,2K5I9@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5683112_0	1123267.JONN01000002_gene341	4.118e-214	674.0	COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,2TTNX@28211|Alphaproteobacteria,2K1FW@204457|Sphingomonadales	204457|Sphingomonadales	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
HFD1_k127_5683112_1	629773.AORY01000012_gene725	6.088e-177	557.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2U1KM@28211|Alphaproteobacteria,2K0PB@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HFD1_k127_5699767_4	1123267.JONN01000001_gene1873	7.863e-41	153.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2K11G@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD1_k127_5699767_0	1123269.NX02_24415	2.122e-144	467.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,2K10W@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HFD1_k127_5699767_1	1123267.JONN01000001_gene1875	1.399e-143	464.0	COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,2TSMC@28211|Alphaproteobacteria,2K2MN@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HFD1_k127_5699767_3	1123267.JONN01000001_gene1876	1.129e-72	263.0	COG0746@1|root,COG0746@2|Bacteria,1QWF1@1224|Proteobacteria,2TXF5@28211|Alphaproteobacteria,2KEHV@204457|Sphingomonadales	204457|Sphingomonadales	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HFD1_k127_5699767_2	1123267.JONN01000001_gene1877	3.331e-106	348.0	COG0560@1|root,COG0560@2|Bacteria,1P4TB@1224|Proteobacteria,2UHTZ@28211|Alphaproteobacteria,2K3BN@204457|Sphingomonadales	204457|Sphingomonadales	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HFD1_k127_5703479_0	1123267.JONN01000001_gene849	0.0	1082.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,2K0KI@204457|Sphingomonadales	204457|Sphingomonadales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
HFD1_k127_5703479_2	658612.MD26_01650	5.149e-60	215.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,1S4DC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NAD(P)H-dependent FMN reductase	chrR	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
HFD1_k127_5703479_3	1120792.JAFV01000001_gene662	7.293e-40	152.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,36YV8@31993|Methylocystaceae	28211|Alphaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HFD1_k127_5703479_1	1123269.NX02_10205	7.4e-149	481.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2TR62@28211|Alphaproteobacteria,2K1KR@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HFD1_k127_5703479_4	1123269.NX02_05965	2.253e-38	143.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2TSDM@28211|Alphaproteobacteria,2JZVF@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HFD1_k127_5705785_1	1123267.JONN01000001_gene1067	3.765e-100	337.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2K07V@204457|Sphingomonadales	204457|Sphingomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HFD1_k127_5705785_2	1123267.JONN01000001_gene1068	4.442e-34	132.0	COG2938@1|root,COG2938@2|Bacteria,1N6SJ@1224|Proteobacteria,2VCGJ@28211|Alphaproteobacteria,2K5W5@204457|Sphingomonadales	204457|Sphingomonadales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
HFD1_k127_5705785_0	1030157.AFMP01000044_gene1790	7.774e-139	451.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,2K0MC@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP-dependent DNA helicase RecG	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HFD1_k127_5729320_4	46429.BV95_02085	3.847e-52	192.0	COG4961@1|root,COG4961@2|Bacteria,1QV5Z@1224|Proteobacteria,2TWAQ@28211|Alphaproteobacteria,2K52P@204457|Sphingomonadales	204457|Sphingomonadales	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HFD1_k127_5729320_1	1123267.JONN01000001_gene641	1.517e-187	593.0	COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,2TU4T@28211|Alphaproteobacteria,2K07G@204457|Sphingomonadales	204457|Sphingomonadales	P	Toxic anion resistance	-	-	-	-	-	-	-	-	-	-	-	-	TelA
HFD1_k127_5729320_3	1123267.JONN01000001_gene640	3.768e-71	248.0	2F69V@1|root,33YTJ@2|Bacteria,1MYST@1224|Proteobacteria,2UA2M@28211|Alphaproteobacteria,2K4MC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5729320_7	298655.KI912266_gene3738	2.577e-05	57.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4EVA2@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HFD1_k127_5729320_5	392499.Swit_0230	1.107e-38	153.0	2ENSP@1|root,33GDV@2|Bacteria,1N3J8@1224|Proteobacteria,2UBZE@28211|Alphaproteobacteria,2K5KK@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5729320_2	596154.Alide2_3497	5.51e-140	460.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,4AAG0@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HFD1_k127_5729320_0	1123267.JONN01000001_gene636	2.678e-275	854.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2JZXX@204457|Sphingomonadales	204457|Sphingomonadales	Q	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HFD1_k127_5729320_6	1121861.KB899918_gene3284	2.774e-35	139.0	COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2U9MH@28211|Alphaproteobacteria,2JSQV@204441|Rhodospirillales	204441|Rhodospirillales	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HFD1_k127_5755115_10	1229172.JQFA01000002_gene2623	1.392e-08	55.0	COG0667@1|root,COG0667@2|Bacteria,1G11W@1117|Cyanobacteria,1HEZH@1150|Oscillatoriales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_5755115_5	46429.BV95_02465	1.071e-76	263.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,2K1F6@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HFD1_k127_5755115_9	685778.AORL01000022_gene1548	6.006e-22	104.0	COG0457@1|root,COG0457@2|Bacteria,1MYZ1@1224|Proteobacteria,2UCPV@28211|Alphaproteobacteria,2K4IW@204457|Sphingomonadales	204457|Sphingomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HFD1_k127_5755115_3	685035.ADAE01000018_gene694	5.858e-94	314.0	COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,2U5D2@28211|Alphaproteobacteria,2K0TS@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
HFD1_k127_5755115_4	1112216.JH594425_gene1623	6.865e-88	297.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2K0DY@204457|Sphingomonadales	204457|Sphingomonadales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HFD1_k127_5755115_8	1123267.JONN01000001_gene1918	1.661e-22	102.0	2FB68@1|root,30QV6@2|Bacteria,1NWWK@1224|Proteobacteria,2US5H@28211|Alphaproteobacteria,2K6YE@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5755115_0	1123267.JONN01000001_gene1917	1.641e-269	839.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,2K12J@204457|Sphingomonadales	204457|Sphingomonadales	I	synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HFD1_k127_5755115_1	627192.SLG_01570	4.353e-241	757.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2K0PZ@204457|Sphingomonadales	204457|Sphingomonadales	E	gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HFD1_k127_5755115_2	1123267.JONN01000001_gene2071	2.264e-145	467.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,2K1QF@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HFD1_k127_5755115_6	392499.Swit_2919	1.274e-44	165.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,2UAVK@28211|Alphaproteobacteria,2K421@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HFD1_k127_5755115_7	1123267.JONN01000001_gene2069	3.603e-39	154.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,2K196@204457|Sphingomonadales	204457|Sphingomonadales	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HFD1_k127_5777924_3	864069.MicloDRAFT_00018100	1.137e-52	190.0	COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2U7DZ@28211|Alphaproteobacteria,1JUU6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Lactoylglutathione lyase	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_5777924_2	1545915.JROG01000008_gene3385	1.224e-79	271.0	COG1733@1|root,COG1733@2|Bacteria,1R6MK@1224|Proteobacteria,2U2KM@28211|Alphaproteobacteria,2K4SU@204457|Sphingomonadales	204457|Sphingomonadales	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,HxlR,SCP2
HFD1_k127_5777924_0	1123267.JONN01000001_gene2013	2.316e-193	607.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,2K0S6@204457|Sphingomonadales	204457|Sphingomonadales	S	Aerobic cobaltochelatase subunit CobS	-	-	6.6.1.2	ko:K09882	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	AAA_5,CbbQ_C,CobS_N
HFD1_k127_5777924_1	1122137.AQXF01000002_gene429	6.103e-134	445.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,HemolysinCabind,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8,Reprolysin_4
HFD1_k127_5777924_4	1123267.JONN01000001_gene2014	6.391e-28	116.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,2JZUK@204457|Sphingomonadales	204457|Sphingomonadales	H	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase)	-	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
HFD1_k127_5779387_2	1090319.KE386571_gene156	7.413e-41	151.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K05X@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HFD1_k127_5779387_0	1123267.JONN01000002_gene97	2.629e-57	211.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria,2K422@204457|Sphingomonadales	204457|Sphingomonadales	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HFD1_k127_5779387_1	1123267.JONN01000002_gene96	5.641e-49	177.0	COG1725@1|root,COG1725@2|Bacteria,1MZG9@1224|Proteobacteria,2UBQ4@28211|Alphaproteobacteria,2K632@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HFD1_k127_5779387_3	1123267.JONN01000002_gene94	1.984e-15	76.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria,2K1JS@204457|Sphingomonadales	204457|Sphingomonadales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HFD1_k127_5787020_2	1123267.JONN01000001_gene1873	1.602e-99	327.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2K11G@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HFD1_k127_5787020_1	1123267.JONN01000001_gene1872	1.246e-132	429.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,2K12E@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HFD1_k127_5787020_3	1123267.JONN01000001_gene1871	2.626e-55	201.0	COG3218@1|root,COG3218@2|Bacteria,1RKTW@1224|Proteobacteria,2UAXY@28211|Alphaproteobacteria,2K5KR@204457|Sphingomonadales	204457|Sphingomonadales	S	transport system auxiliary component	linN	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HFD1_k127_5787020_5	983545.Glaag_2950	1.777e-33	134.0	COG0662@1|root,COG0662@2|Bacteria,1QX05@1224|Proteobacteria,1T31V@1236|Gammaproteobacteria,46D37@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_5787020_0	1123269.NX02_26025	0.0	1135.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,2K072@204457|Sphingomonadales	204457|Sphingomonadales	E	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HFD1_k127_5787020_6	1123267.JONN01000001_gene1946	1.49e-30	123.0	COG3798@1|root,COG3798@2|Bacteria,1N2FJ@1224|Proteobacteria,2UC84@28211|Alphaproteobacteria,2K6QA@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
HFD1_k127_5787020_7	1082933.MEA186_26269	6.544e-14	74.0	2BWFP@1|root,349N4@2|Bacteria,1P1PG@1224|Proteobacteria,2UU2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	macB	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5787020_4	1219045.BV98_003394	3.881e-36	147.0	COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,2UCF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	DnaK suppressor protein	dskA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HFD1_k127_5817074_0	1123267.JONN01000001_gene1781	2.663e-116	385.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K1AE@204457|Sphingomonadales	204457|Sphingomonadales	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
HFD1_k127_5817074_1	1123267.JONN01000001_gene1780	2.158e-34	135.0	COG1028@1|root,COG1028@2|Bacteria,1R8HN@1224|Proteobacteria,2U0TG@28211|Alphaproteobacteria,2K2FB@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HFD1_k127_5822118_3	745310.G432_16360	8.322e-23	99.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,2K5EU@204457|Sphingomonadales	204457|Sphingomonadales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HFD1_k127_5822118_5	1332071.L581_3511	4.326e-15	83.0	2BT9I@1|root,32NEY@2|Bacteria,1QIC3@1224|Proteobacteria,1TG6C@1236|Gammaproteobacteria,4050S@613|Serratia	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3828)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3828
HFD1_k127_5822118_1	1415780.JPOG01000001_gene2095	3.308e-33	134.0	COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,1S1DG@1236|Gammaproteobacteria,1X810@135614|Xanthomonadales	135614|Xanthomonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,DUF4440
HFD1_k127_5822118_0	627192.SLG_33740	1.266e-310	961.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2K169@204457|Sphingomonadales	204457|Sphingomonadales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HFD1_k127_5822118_4	1123267.JONN01000001_gene1715	1.488e-21	95.0	COG3668@1|root,32ZH9@2|Bacteria,1N7YH@1224|Proteobacteria,2UC0X@28211|Alphaproteobacteria,2K645@204457|Sphingomonadales	204457|Sphingomonadales	S	Plasmid stabilization	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_5822118_6	1450694.BTS2_2398	4.384e-06	54.0	COG1846@1|root,COG1846@2|Bacteria,1V9RE@1239|Firmicutes,4HJ9C@91061|Bacilli,1ZR4W@1386|Bacillus	91061|Bacilli	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HFD1_k127_5822118_2	1123267.JONN01000001_gene1716	5.512e-28	117.0	COG0477@1|root,COG2814@2|Bacteria,1NGB4@1224|Proteobacteria,2TWAK@28211|Alphaproteobacteria,2K8XV@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD1_k127_5898802_1	1461694.ATO9_00105	4.738e-71	250.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2PDTE@252301|Oceanicola	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HFD1_k127_5898802_3	1041146.ATZB01000007_gene2900	4.137e-54	197.0	COG2606@1|root,COG2606@2|Bacteria,1RD82@1224|Proteobacteria,2U7H0@28211|Alphaproteobacteria,4BDW4@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Aminoacyl-tRNA editing domain	MA20_06000	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HFD1_k127_5898802_2	1549858.MC45_04650	3.707e-54	194.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,2K4HM@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HFD1_k127_5898802_0	1123267.JONN01000002_gene325	1.68e-187	604.0	COG2200@1|root,COG4252@1|root,COG2200@2|Bacteria,COG4252@2|Bacteria,1N299@1224|Proteobacteria,2U5C8@28211|Alphaproteobacteria,2K2WP@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,EAL
HFD1_k127_5984717_5	1123267.JONN01000001_gene1761	2.06e-48	174.0	COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2U8FG@28211|Alphaproteobacteria,2K3X0@204457|Sphingomonadales	204457|Sphingomonadales	S	secretion activating protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_108,PG_binding_3
HFD1_k127_5984717_4	1335760.ASTG01000006_gene1412	1.957e-58	209.0	COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2U7RR@28211|Alphaproteobacteria,2K51K@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HFD1_k127_5984717_2	702113.PP1Y_AT12146	2.474e-87	301.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,2K0IZ@204457|Sphingomonadales	204457|Sphingomonadales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HFD1_k127_5984717_1	1120705.FG95_03100	5.339e-147	473.0	COG0665@1|root,COG0665@2|Bacteria,1Q9VR@1224|Proteobacteria,2U05R@28211|Alphaproteobacteria,2K32V@204457|Sphingomonadales	204457|Sphingomonadales	E	D-amino acid	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HFD1_k127_5984717_0	1123267.JONN01000001_gene1766	8.267e-214	680.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,2K0UP@204457|Sphingomonadales	204457|Sphingomonadales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HFD1_k127_5984717_3	1123267.JONN01000001_gene1768	1.426e-74	257.0	2BXI0@1|root,2Z9A2@2|Bacteria,1MZF7@1224|Proteobacteria,2UCIX@28211|Alphaproteobacteria,2K3UM@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2459)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2459
HFD1_k127_604146_11	1304275.C41B8_00915	3.858e-77	275.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST,RimK
HFD1_k127_604146_2	1123267.JONN01000001_gene1881	1.973e-224	701.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,2K1W3@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HFD1_k127_604146_9	1090320.KB900605_gene1242	1.693e-104	351.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,2K13X@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HFD1_k127_604146_14	1550073.JROH01000006_gene1499	2.181e-47	177.0	COG0454@1|root,COG0456@2|Bacteria,1MZA6@1224|Proteobacteria,2UCC0@28211|Alphaproteobacteria,2K4CY@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD1_k127_604146_8	1123267.JONN01000001_gene1942	2.145e-117	386.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,2K21E@204457|Sphingomonadales	204457|Sphingomonadales	M	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	ko:K18164	ko04714,map04714	-	-	-	ko00000,ko00001,ko03029	-	-	-	Methyltransf_28
HFD1_k127_604146_5	1123267.JONN01000001_gene1941	7.788e-140	449.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,2K1JZ@204457|Sphingomonadales	204457|Sphingomonadales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HFD1_k127_604146_1	1123267.JONN01000001_gene1940	2.346e-240	760.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JZZB@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HFD1_k127_604146_4	1123267.JONN01000001_gene1939	2.948e-166	547.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2K25R@204457|Sphingomonadales	204457|Sphingomonadales	C	aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HFD1_k127_604146_6	1123267.JONN01000001_gene1938	5.704e-139	454.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,2K0NQ@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HFD1_k127_604146_7	1123267.JONN01000001_gene1937	2.185e-130	419.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,2K0A2@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Acetoacetyl-CoA reductase	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HFD1_k127_604146_15	1537715.JQFJ01000002_gene2439	1.658e-24	110.0	COG4321@1|root,COG4321@2|Bacteria,1PSCA@1224|Proteobacteria,2VA8Q@28211|Alphaproteobacteria,2K6W1@204457|Sphingomonadales	204457|Sphingomonadales	S	protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	RHH_4
HFD1_k127_604146_0	685778.AORL01000009_gene3208	0.0	1772.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2K0WP@204457|Sphingomonadales	204457|Sphingomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
HFD1_k127_604146_13	1502850.FG91_03201	4.744e-60	211.0	2DEWU@1|root,2ZPJP@2|Bacteria,1NBPN@1224|Proteobacteria,2VGJK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_604146_16	1044.EH31_00890	3.397e-07	57.0	2AAQE@1|root,3102J@2|Bacteria,1PN2N@1224|Proteobacteria,2V0NX@28211|Alphaproteobacteria,2KAKV@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_604146_10	402626.Rpic_3558	5.626e-95	320.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,1K23R@119060|Burkholderiaceae	28216|Betaproteobacteria	H	2-dehydropantoate 2-reductase	panE2	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD1_k127_604146_3	1123267.JONN01000001_gene1930	1.614e-180	576.0	COG0179@1|root,COG0179@2|Bacteria,1MW82@1224|Proteobacteria,2TRKH@28211|Alphaproteobacteria,2K0SS@204457|Sphingomonadales	204457|Sphingomonadales	Q	Fumarylacetoacetase	-	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HFD1_k127_604146_12	1449076.JOOE01000001_gene2370	5.855e-76	255.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2K0UM@204457|Sphingomonadales	204457|Sphingomonadales	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HFD1_k127_6056574_4	517417.Cpar_0721	6.023e-77	265.0	COG1770@1|root,COG1770@2|Bacteria,1FDQZ@1090|Chlorobi	1090|Chlorobi	E	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.21.26,3.4.21.83	ko:K01322,ko:K01354	ko04614,ko05142,ko05143,map04614,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HFD1_k127_6056574_6	1238182.C882_4193	8.562e-32	130.0	COG2867@1|root,COG2867@2|Bacteria,1PPRM@1224|Proteobacteria,2UJ52@28211|Alphaproteobacteria,2JU9G@204441|Rhodospirillales	204441|Rhodospirillales	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
HFD1_k127_6056574_1	1123267.JONN01000001_gene2476	2.796e-209	658.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TRE3@28211|Alphaproteobacteria,2K0GY@204457|Sphingomonadales	204457|Sphingomonadales	E	Aminotransferase	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_6056574_2	1123267.JONN01000001_gene371	1.559e-95	316.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2U6B7@28211|Alphaproteobacteria,2KD4Q@204457|Sphingomonadales	204457|Sphingomonadales	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
HFD1_k127_6056574_0	1123267.JONN01000001_gene372	3.949e-277	863.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2K0U9@204457|Sphingomonadales	204457|Sphingomonadales	I	poly(R)-hydroxyalkanoic acid synthase	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HFD1_k127_6056574_7	1320556.AVBP01000009_gene2469	5.946e-28	119.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	yrkN	-	2.3.1.82	ko:K03826,ko:K03827,ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HFD1_k127_6056574_5	1300345.LF41_1001	4.191e-54	199.0	COG4430@1|root,COG4430@2|Bacteria,1RG2R@1224|Proteobacteria,1T0AD@1236|Gammaproteobacteria,1X6JK@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
HFD1_k127_6056574_9	1537715.JQFJ01000002_gene983	2.283e-24	105.0	2EIB4@1|root,33C2I@2|Bacteria,1NCTY@1224|Proteobacteria,2UHUB@28211|Alphaproteobacteria,2K6ZK@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6056574_3	1123267.JONN01000001_gene374	5.518e-95	323.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,2TV8D@28211|Alphaproteobacteria,2K1SV@204457|Sphingomonadales	204457|Sphingomonadales	S	RarD protein	-	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
HFD1_k127_6056574_10	1123267.JONN01000001_gene375	2.181e-22	101.0	2E21J@1|root,32X9B@2|Bacteria,1NEYU@1224|Proteobacteria,2UJ33@28211|Alphaproteobacteria,2K6I0@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4893)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4893
HFD1_k127_6113918_0	1095769.CAHF01000011_gene2467	2.095e-98	342.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	3HBOH,Tannase
HFD1_k127_6122109_3	1123267.JONN01000001_gene1904	7.392e-75	258.0	COG1287@1|root,COG1287@2|Bacteria,1RCIB@1224|Proteobacteria,2U677@28211|Alphaproteobacteria,2K1YU@204457|Sphingomonadales	204457|Sphingomonadales	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6122109_2	1123267.JONN01000001_gene1903	9.762e-77	264.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,2K0G8@204457|Sphingomonadales	204457|Sphingomonadales	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HFD1_k127_6122109_4	1123267.JONN01000001_gene1902	7.643e-44	167.0	2ANEF@1|root,31DD2@2|Bacteria,1RHST@1224|Proteobacteria,2UA6U@28211|Alphaproteobacteria,2K5G6@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6122109_0	745310.G432_08255	2.986e-126	419.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,2K03K@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HFD1_k127_6122109_5	685778.AORL01000022_gene1473	4.689e-25	107.0	COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria,2K6UW@204457|Sphingomonadales	204457|Sphingomonadales	S	integral membrane protein	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HFD1_k127_6122109_1	1090319.KE386571_gene1238	5.107e-104	344.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,2K0WW@204457|Sphingomonadales	204457|Sphingomonadales	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HFD1_k127_6229771_3	13689.BV96_02351	5.038e-66	230.0	COG3145@1|root,COG3145@2|Bacteria,1RDBK@1224|Proteobacteria,2U808@28211|Alphaproteobacteria,2K4HF@204457|Sphingomonadales	204457|Sphingomonadales	L	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
HFD1_k127_6229771_2	935840.JAEQ01000003_gene276	1.84e-134	443.0	COG1793@1|root,COG1793@2|Bacteria,1R4SI@1224|Proteobacteria,2U213@28211|Alphaproteobacteria,43JJJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	ATP dependent DNA ligase	ligC	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HFD1_k127_6229771_0	1174684.EBMC1_15679	6.022e-148	479.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2TVI9@28211|Alphaproteobacteria,2K2GU@204457|Sphingomonadales	204457|Sphingomonadales	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HFD1_k127_6229771_1	670292.JH26_06965	8.086e-146	473.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,1JRQV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM Rh family protein ammonium transporter	amtB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015291,GO:0015292,GO:0015669,GO:0015670,GO:0015696,GO:0015893,GO:0016020,GO:0016021,GO:0019755,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HFD1_k127_6229771_4	598659.NAMH_1184	1.504e-12	68.0	2AY0S@1|root,31Q2B@2|Bacteria,1QMQY@1224|Proteobacteria,42SY0@68525|delta/epsilon subdivisions,2YPGA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Bacteriophage replication gene A protein (GPA)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPA
HFD1_k127_6229771_5	1150469.RSPPHO_02107	1.656e-08	56.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2JR6A@204441|Rhodospirillales	204441|Rhodospirillales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HFD1_k127_6279154_1	1123267.JONN01000001_gene381	8.236e-80	271.0	COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria,2K1FD@204457|Sphingomonadales	204457|Sphingomonadales	O	Chaperone required for the assembly of the mitochondrial F1-ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ATP12
HFD1_k127_6279154_0	161528.ED21_21299	7.406e-82	284.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,2K16A@204457|Sphingomonadales	204457|Sphingomonadales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HFD1_k127_6279154_2	1123267.JONN01000001_gene379	1.257e-36	148.0	COG5490@1|root,COG5490@2|Bacteria,1N3RI@1224|Proteobacteria,2UDTZ@28211|Alphaproteobacteria,2K476@204457|Sphingomonadales	204457|Sphingomonadales	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HFD1_k127_6288990_5	1123267.JONN01000001_gene1330	2.674e-69	244.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,2JZZS@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HFD1_k127_6288990_3	1123267.JONN01000001_gene1331	5.172e-95	313.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,2K01J@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HFD1_k127_6288990_2	392499.Swit_2992	2.288e-186	587.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,2JZYY@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HFD1_k127_6288990_0	1123267.JONN01000001_gene1333	0.0	1087.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,2K16X@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
HFD1_k127_6288990_1	1123267.JONN01000001_gene1336	1.588e-258	803.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,2JZYB@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HFD1_k127_6288990_4	1123267.JONN01000001_gene1338	1.949e-84	282.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,2K18U@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH dehydrogenase	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HFD1_k127_6428909_0	1305735.JAFT01000005_gene1417	2.099e-236	741.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2PF3V@252301|Oceanicola	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HFD1_k127_6435806_3	1123267.JONN01000001_gene754	2.675e-223	699.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K02W@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidase M13	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M13,Peptidase_M13_N
HFD1_k127_6435806_5	1123267.JONN01000001_gene756	6.81e-198	626.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,2K1P6@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c
HFD1_k127_6435806_7	1123267.JONN01000001_gene757	2.938e-131	422.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,2K0M9@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HFD1_k127_6435806_8	1123267.JONN01000001_gene758	1.523e-22	100.0	29288@1|root,2ZPSV@2|Bacteria,1NJAG@1224|Proteobacteria,2UMCR@28211|Alphaproteobacteria,2K6S1@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
HFD1_k127_6435806_0	1123267.JONN01000001_gene759	1.871e-294	912.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,2K0QQ@204457|Sphingomonadales	204457|Sphingomonadales	S	of ABC transporters with duplicated ATPase	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
HFD1_k127_6435806_1	1123267.JONN01000001_gene761	7.417e-280	872.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0TH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HFD1_k127_6435806_4	1123267.JONN01000001_gene764	4.363e-218	684.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2K0MW@204457|Sphingomonadales	204457|Sphingomonadales	T	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HFD1_k127_6435806_2	1123267.JONN01000001_gene765	6.834e-224	713.0	COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,2TXJW@28211|Alphaproteobacteria,2KEK6@204457|Sphingomonadales	204457|Sphingomonadales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c
HFD1_k127_6435806_6	1123269.NX02_22535	1.668e-155	496.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales	204457|Sphingomonadales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_6447590_2	1123267.JONN01000001_gene2049	3.62e-113	368.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,2K15Q@204457|Sphingomonadales	204457|Sphingomonadales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HFD1_k127_6447590_0	1123267.JONN01000001_gene2050	0.0	1177.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JZY4@204457|Sphingomonadales	204457|Sphingomonadales	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HFD1_k127_6447590_1	1123267.JONN01000001_gene2051	2.583e-115	377.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,2K09S@204457|Sphingomonadales	204457|Sphingomonadales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HFD1_k127_6461920_1	1123267.JONN01000001_gene1238	5.323e-143	464.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
HFD1_k127_6461920_2	1123267.JONN01000001_gene1239	7.34e-93	316.0	2C1YS@1|root,2ZD2Y@2|Bacteria	2|Bacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HFD1_k127_6461920_3	1112216.JH594425_gene3509	5.992e-87	295.0	COG5429@1|root,COG5429@2|Bacteria,1RB45@1224|Proteobacteria,2U5EW@28211|Alphaproteobacteria,2KD65@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HFD1_k127_6461920_0	420324.KI912025_gene67	1.09e-207	664.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,1JSCQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HFD1_k127_6481741_2	1123267.JONN01000001_gene583	4.8e-92	309.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U0U5@28211|Alphaproteobacteria,2K08M@204457|Sphingomonadales	204457|Sphingomonadales	V	proteins, homologs of microcin C7 resistance protein MccF	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HFD1_k127_6481741_11	670292.JH26_10125	3.555e-30	124.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,2UC9T@28211|Alphaproteobacteria,1JV0G@119045|Methylobacteriaceae	28211|Alphaproteobacteria	B	PFAM SWIB MDM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HFD1_k127_6481741_7	1090320.KB900605_gene1533	5.797e-58	214.0	COG1051@1|root,COG1051@2|Bacteria,1QUPQ@1224|Proteobacteria,2TW3M@28211|Alphaproteobacteria,2K0RT@204457|Sphingomonadales	204457|Sphingomonadales	F	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD1_k127_6481741_10	1545915.JROG01000003_gene1156	1.706e-42	166.0	2D5TK@1|root,3133H@2|Bacteria,1NRIX@1224|Proteobacteria,2UQRX@28211|Alphaproteobacteria,2K6JR@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6481741_0	1112212.JH584235_gene308	9.156e-215	689.0	COG1228@1|root,COG1228@2|Bacteria,1R7TW@1224|Proteobacteria,2VFMX@28211|Alphaproteobacteria,2KDXF@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_6481741_8	685778.AORL01000022_gene1306	1.324e-56	201.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,2K54X@204457|Sphingomonadales	204457|Sphingomonadales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HFD1_k127_6481741_3	1123267.JONN01000001_gene589	1.394e-91	304.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2TRJR@28211|Alphaproteobacteria,2K3WZ@204457|Sphingomonadales	204457|Sphingomonadales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HFD1_k127_6481741_4	1123267.JONN01000001_gene591	1.439e-77	269.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,2K1AR@204457|Sphingomonadales	204457|Sphingomonadales	S	Methanol dehydrogenase	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD1_k127_6481741_6	1449076.JOOE01000003_gene3799	7.642e-62	225.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,2K470@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HFD1_k127_6481741_9	1123267.JONN01000001_gene593	2.96e-56	201.0	COG0494@1|root,COG0494@2|Bacteria,1RE72@1224|Proteobacteria,2U805@28211|Alphaproteobacteria,2K4H0@204457|Sphingomonadales	204457|Sphingomonadales	L	Nudix hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HFD1_k127_6481741_1	1123267.JONN01000001_gene596	3.496e-107	355.0	COG1409@1|root,COG1409@2|Bacteria,1MW6B@1224|Proteobacteria,2U1GX@28211|Alphaproteobacteria,2K28P@204457|Sphingomonadales	204457|Sphingomonadales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_6481741_5	1123267.JONN01000001_gene597	1.561e-64	224.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,2K19F@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the NadC ModD family	-	-	-	-	-	-	-	-	-	-	-	-	QRPTase_C,QRPTase_N
HFD1_k127_6541769_5	1123267.JONN01000002_gene188	5.783e-65	225.0	COG0745@1|root,COG0745@2|Bacteria,1QUSA@1224|Proteobacteria,2TW5G@28211|Alphaproteobacteria,2K5A5@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	ko:K13589	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HFD1_k127_6541769_4	1123267.JONN01000002_gene187	3e-77	268.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,2K41R@204457|Sphingomonadales	204457|Sphingomonadales	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
HFD1_k127_6541769_3	1123267.JONN01000002_gene186	1.769e-112	370.0	2D4T1@1|root,32THI@2|Bacteria,1N892@1224|Proteobacteria,2TWF7@28211|Alphaproteobacteria,2KEER@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM SapC family protein	-	-	-	-	-	-	-	-	-	-	-	-	SapC
HFD1_k127_6541769_8	1123267.JONN01000002_gene185	8.868e-34	134.0	2AM8F@1|root,31C39@2|Bacteria,1N008@1224|Proteobacteria,2UCNF@28211|Alphaproteobacteria,2K748@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6541769_0	1123267.JONN01000002_gene184	3.278e-195	617.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,2K0CY@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the DEAD box helicase family	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HFD1_k127_6541769_2	1346791.M529_18160	1.439e-148	475.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTDF@28211|Alphaproteobacteria,2K19J@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N
HFD1_k127_6541769_1	1123267.JONN01000002_gene179	2.285e-191	603.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,2K0II@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HFD1_k127_6541769_7	999611.KI421504_gene2151	2.031e-46	172.0	COG3791@1|root,COG3791@2|Bacteria,1RKSX@1224|Proteobacteria,2UBA9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD1_k127_6541769_6	1123267.JONN01000002_gene175	3.027e-60	212.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,2TW57@28211|Alphaproteobacteria,2K36T@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HFD1_k127_6557784_4	1332071.L581_3511	1.467e-11	71.0	2BT9I@1|root,32NEY@2|Bacteria,1QIC3@1224|Proteobacteria,1TG6C@1236|Gammaproteobacteria,4050S@613|Serratia	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3828)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3828
HFD1_k127_6557784_1	1030157.AFMP01000019_gene660	9.866e-51	183.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,2K5EU@204457|Sphingomonadales	204457|Sphingomonadales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HFD1_k127_6557784_3	1123267.JONN01000001_gene1713	2.125e-45	174.0	COG3773@1|root,COG3773@2|Bacteria,1RDSV@1224|Proteobacteria,2U8XY@28211|Alphaproteobacteria,2K4PG@204457|Sphingomonadales	2|Bacteria	M	COG3773 Cell wall hydrolyses involved in spore germination	cwlJ	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2
HFD1_k127_6557784_0	1123267.JONN01000001_gene1712	1.133e-63	223.0	COG0784@1|root,COG0784@2|Bacteria,1Q8CG@1224|Proteobacteria,2VEIV@28211|Alphaproteobacteria,2K7Z1@204457|Sphingomonadales	204457|Sphingomonadales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HFD1_k127_6557784_2	450851.PHZ_c3271	1.093e-46	170.0	COG0625@1|root,COG0625@2|Bacteria,1NUET@1224|Proteobacteria,2TRGC@28211|Alphaproteobacteria,2KJCX@204458|Caulobacterales	204458|Caulobacterales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
HFD1_k127_6567613_2	1120705.FG95_03857	6.432e-96	324.0	2C3PP@1|root,2Z954@2|Bacteria,1MXGR@1224|Proteobacteria,2TS01@28211|Alphaproteobacteria,2K2TC@204457|Sphingomonadales	204457|Sphingomonadales	S	Branched-chain amino acid aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6567613_1	237727.NAP1_05465	2.296e-142	462.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TQR9@28211|Alphaproteobacteria,2K6X7@204457|Sphingomonadales	204457|Sphingomonadales	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HFD1_k127_6567613_3	1090319.KE386571_gene1178	7.054e-93	316.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2TVQV@28211|Alphaproteobacteria,2JZZM@204457|Sphingomonadales	204457|Sphingomonadales	P	cation diffusion facilitator	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HFD1_k127_6567613_0	1174684.EBMC1_16059	5.434e-167	529.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_6575726_0	1248760.ANFZ01000011_gene167	1.577e-67	240.0	COG1482@1|root,COG1482@2|Bacteria,1P6JR@1224|Proteobacteria,2U30V@28211|Alphaproteobacteria,2K0Y1@204457|Sphingomonadales	204457|Sphingomonadales	G	isomerase	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HFD1_k127_6575726_2	1112214.AHIS01000050_gene2412	2.049e-30	127.0	COG0526@1|root,COG0526@2|Bacteria,1PVQ1@1224|Proteobacteria,2VC1J@28211|Alphaproteobacteria,2KAU7@204457|Sphingomonadales	204457|Sphingomonadales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6575726_1	1112214.AHIS01000050_gene2413	3.096e-58	207.0	COG0785@1|root,COG0785@2|Bacteria,1MVV0@1224|Proteobacteria,2TUNG@28211|Alphaproteobacteria,2K5TQ@204457|Sphingomonadales	204457|Sphingomonadales	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
HFD1_k127_6580797_0	460265.Mnod_0848	1.58e-176	560.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2TUG0@28211|Alphaproteobacteria,1JYZZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HFD1_k127_6602280_4	1123267.JONN01000002_gene345	6.597e-99	331.0	COG4783@1|root,COG4783@2|Bacteria,1RAJB@1224|Proteobacteria,2TRY3@28211|Alphaproteobacteria,2JZYT@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD1_k127_6602280_3	1123267.JONN01000002_gene344	8.699e-103	342.0	2EDW0@1|root,32VXH@2|Bacteria,1R3JT@1224|Proteobacteria,2U03S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6602280_2	1449076.JOOE01000002_gene1394	1.74e-181	582.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,2U4ZG@28211|Alphaproteobacteria,2K230@204457|Sphingomonadales	204457|Sphingomonadales	S	Alkaline phosphatase with broad substrate specificity	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Phosphodiest
HFD1_k127_6602280_0	1123267.JONN01000002_gene126	5.692e-265	821.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,2K04H@204457|Sphingomonadales	204457|Sphingomonadales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HFD1_k127_6602280_1	1219049.SP5_073_00730	4.976e-217	679.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,2K0UD@204457|Sphingomonadales	204457|Sphingomonadales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HFD1_k127_6620798_7	1183438.GKIL_2082	8.201e-51	181.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1GDGA@1117|Cyanobacteria	1117|Cyanobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HFD1_k127_6620798_6	1234595.C725_1068	3.237e-62	221.0	COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2U773@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	1.14.11.2	ko:K00472	ko00330,ko01100,map00330,map01100	-	R01252	RC00478	ko00000,ko00001,ko01000	-	-	-	2OG-FeII_Oxy_3
HFD1_k127_6620798_4	1123267.JONN01000001_gene1349	4.399e-92	312.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria,2K16H@204457|Sphingomonadales	204457|Sphingomonadales	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HFD1_k127_6620798_3	1123267.JONN01000001_gene1352	3.885e-143	459.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TU2S@28211|Alphaproteobacteria,2K14P@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HFD1_k127_6620798_5	314225.ELI_05225	3.826e-68	239.0	COG3751@1|root,COG3751@2|Bacteria,1QWIY@1224|Proteobacteria,2TWYQ@28211|Alphaproteobacteria,2KEGE@204457|Sphingomonadales	204457|Sphingomonadales	O	Putative 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5
HFD1_k127_6620798_0	1123267.JONN01000001_gene1353	1.334e-206	649.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,2K0JN@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HFD1_k127_6620798_1	1449076.JOOE01000001_gene1911	1.047e-180	572.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,2K0GC@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HFD1_k127_6620798_2	1449076.JOOE01000001_gene1912	4.277e-150	481.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2K0UZ@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the transketolase family	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HFD1_k127_6672671_0	292459.STH308	6.368e-106	358.0	COG3328@1|root,COG3328@2|Bacteria,1V116@1239|Firmicutes,24D8K@186801|Clostridia	186801|Clostridia	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HFD1_k127_6672877_16	1123267.JONN01000001_gene817	5.125e-54	196.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,2K59A@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidase M22	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M22
HFD1_k127_6672877_18	1123267.JONN01000001_gene816	6.32e-45	168.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,2K616@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
HFD1_k127_6672877_11	1123267.JONN01000001_gene815	5.377e-67	231.0	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,2K4EY@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
HFD1_k127_6672877_10	1123267.JONN01000001_gene814	9.427e-71	241.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,2K3Z2@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HFD1_k127_6672877_17	317655.Sala_2065	2.693e-53	198.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria,2K221@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HFD1_k127_6672877_1	383381.EH30_08350	7.03e-194	613.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,2K1NH@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HFD1_k127_6672877_4	745310.G432_01315	7.315e-157	502.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,2K21F@204457|Sphingomonadales	204457|Sphingomonadales	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HFD1_k127_6672877_15	1123267.JONN01000001_gene810	6.12e-57	203.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,2K4EE@204457|Sphingomonadales	204457|Sphingomonadales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HFD1_k127_6672877_8	1123267.JONN01000001_gene809	5.771e-120	393.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,2K03F@204457|Sphingomonadales	204457|Sphingomonadales	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
HFD1_k127_6672877_13	383381.EH30_11555	2.754e-63	219.0	COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2U78G@28211|Alphaproteobacteria,2K4FM@204457|Sphingomonadales	204457|Sphingomonadales	S	dioxygenase of extradiol dioxygenase family	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
HFD1_k127_6672877_3	1123267.JONN01000001_gene808	2.204e-166	543.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,2K1Y8@204457|Sphingomonadales	204457|Sphingomonadales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HFD1_k127_6672877_0	1449076.JOOE01000003_gene3239	2.013e-222	694.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,2K02E@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HFD1_k127_6672877_19	347834.RHE_CH01153	1.003e-37	148.0	COG4244@1|root,COG4244@2|Bacteria,1RKBB@1224|Proteobacteria,2UA11@28211|Alphaproteobacteria,4BFTR@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD1_k127_6672877_2	536019.Mesop_3008	9.114e-190	602.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_6672877_20	1123267.JONN01000001_gene936	7.615e-24	108.0	COG4244@1|root,COG4244@2|Bacteria,1RDSW@1224|Proteobacteria,2UDK1@28211|Alphaproteobacteria,2KE6Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HFD1_k127_6672877_7	1123267.JONN01000001_gene804	1.356e-120	390.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria,2K0BM@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HFD1_k127_6672877_9	1219049.SP5_099_00270	5.036e-114	375.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,2TVJ0@28211|Alphaproteobacteria,2K1AT@204457|Sphingomonadales	204457|Sphingomonadales	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HFD1_k127_6672877_6	194867.ALBQ01000022_gene3472	5.216e-132	433.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,2K0QG@204457|Sphingomonadales	204457|Sphingomonadales	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HFD1_k127_6672877_5	1123267.JONN01000001_gene801	2.198e-141	457.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,2K1FI@204457|Sphingomonadales	204457|Sphingomonadales	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
HFD1_k127_6672877_14	1123267.JONN01000001_gene800	5.317e-62	219.0	COG1755@1|root,COG1755@2|Bacteria,1RERZ@1224|Proteobacteria,2U77M@28211|Alphaproteobacteria,2K4HJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
HFD1_k127_6672877_12	745310.G432_07650	1.089e-63	230.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria,2K45N@204457|Sphingomonadales	204457|Sphingomonadales	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HFD1_k127_6672877_21	1123267.JONN01000001_gene794	2.608e-21	94.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,2K1KF@204457|Sphingomonadales	204457|Sphingomonadales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HFD1_k127_6727279_0	13689.BV96_00264	1.152e-149	475.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,2K04G@204457|Sphingomonadales	204457|Sphingomonadales	C	Methylmalonate-semialdehyde dehydrogenase	mmsA	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_6727279_3	1088721.NSU_0415	9.599e-22	100.0	2EKD7@1|root,33E3H@2|Bacteria,1NBMH@1224|Proteobacteria,2UG3V@28211|Alphaproteobacteria,2K4NR@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6727279_2	243159.AFE_2594	1.119e-57	208.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,1RRI3@1236|Gammaproteobacteria,2NDN7@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N_2
HFD1_k127_6727279_1	1123267.JONN01000001_gene1307	6.067e-136	434.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JZVG@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HFD1_k127_6731560_1	1123267.JONN01000001_gene1906	3.047e-97	332.0	COG0500@1|root,COG0500@2|Bacteria,1QUSR@1224|Proteobacteria,2U78U@28211|Alphaproteobacteria,2K1PP@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HFD1_k127_6731560_2	194867.ALBQ01000044_gene1526	4.504e-44	164.0	COG2246@1|root,COG2246@2|Bacteria,1N67P@1224|Proteobacteria,2UDG8@28211|Alphaproteobacteria,2KE35@204457|Sphingomonadales	204457|Sphingomonadales	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HFD1_k127_6731560_0	1123267.JONN01000001_gene1904	7.663e-157	504.0	COG1287@1|root,COG1287@2|Bacteria,1RCIB@1224|Proteobacteria,2U677@28211|Alphaproteobacteria,2K1YU@204457|Sphingomonadales	204457|Sphingomonadales	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6747138_2	1123267.JONN01000002_gene256	8.797e-50	184.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,2K0C7@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HFD1_k127_6747138_0	1123267.JONN01000002_gene257	7.938e-91	301.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,2K28X@204457|Sphingomonadales	204457|Sphingomonadales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HFD1_k127_6747138_1	1096930.L284_12610	9.537e-88	296.0	COG0664@1|root,COG0664@2|Bacteria,1PIN3@1224|Proteobacteria,2TSA8@28211|Alphaproteobacteria,2K3KX@204457|Sphingomonadales	204457|Sphingomonadales	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HFD1_k127_67726_1	1123267.JONN01000001_gene1974	1.617e-94	312.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,2K0F9@204457|Sphingomonadales	204457|Sphingomonadales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HFD1_k127_67726_2	1121123.AUAO01000005_gene1709	2.798e-31	128.0	2C7KN@1|root,336M6@2|Bacteria,1N4WC@1224|Proteobacteria,2UF7X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_67726_0	1123519.PSJM300_03575	8.188e-154	501.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1Z26A@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HFD1_k127_6776267_2	1090319.KE386571_gene2108	6.015e-21	100.0	2AKZG@1|root,31BT4@2|Bacteria,1Q7R6@1224|Proteobacteria,2VDWQ@28211|Alphaproteobacteria,2K6B3@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3833)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3833
HFD1_k127_6776267_0	291985.CCSI01000004_gene605	3.79e-293	913.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2K0M5@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C,DUF779
HFD1_k127_6776267_1	1120983.KB894570_gene1667	4.743e-32	126.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,1JNTN@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	C-C_Bond_Lyase of the TIM-Barrel fold	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD1_k127_6819745_0	1380394.JADL01000001_gene2363	8.654e-263	818.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0840@1|root,COG1511@1|root,COG2203@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVW@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
HFD1_k127_6891461_0	1123267.JONN01000001_gene2339	1.558e-210	657.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,2K034@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HFD1_k127_6891461_1	1123267.JONN01000001_gene2338	1.086e-118	391.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,2K00C@204457|Sphingomonadales	204457|Sphingomonadales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
HFD1_k127_6891461_2	1112212.JH584235_gene1978	5.374e-90	301.0	COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,2TUX2@28211|Alphaproteobacteria,2K1QD@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HFD1_k127_6891461_3	745310.G432_14235	1.362e-52	188.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2K0T4@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HFD1_k127_6900517_1	1380391.JIAS01000011_gene4938	9.258e-104	341.0	COG3806@1|root,COG3806@2|Bacteria,1R52I@1224|Proteobacteria,2U2FN@28211|Alphaproteobacteria,2JZ70@204441|Rhodospirillales	204441|Rhodospirillales	T	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HFD1_k127_6900517_2	1254432.SCE1572_09045	5.93e-98	324.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria	1224|Proteobacteria	O	Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_C_3,GST_N,GST_N_2,GST_N_3
HFD1_k127_6900517_5	1120934.KB894407_gene5013	3.376e-46	172.0	COG1309@1|root,COG1309@2|Bacteria,2GTS6@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HFD1_k127_6900517_3	1123267.JONN01000001_gene1114	3.333e-76	264.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,2U6CN@28211|Alphaproteobacteria,2K2DP@204457|Sphingomonadales	204457|Sphingomonadales	KT	Phage shock protein A	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HFD1_k127_6900517_7	1123267.JONN01000001_gene689	3.924e-18	89.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HFD1_k127_6900517_6	13689.BV96_02222	1.679e-19	90.0	29B0T@1|root,2ZXZQ@2|Bacteria,1ND25@1224|Proteobacteria,2UJ2J@28211|Alphaproteobacteria,2K6SU@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6900517_4	1219035.NT2_02_04530	2.953e-50	180.0	2B9KW@1|root,322Z5@2|Bacteria,1RJJB@1224|Proteobacteria,2UAVD@28211|Alphaproteobacteria,2K6EC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6900517_0	1123267.JONN01000001_gene691	5.507e-175	564.0	COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2TUNP@28211|Alphaproteobacteria,2K1AW@204457|Sphingomonadales	204457|Sphingomonadales	H	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HFD1_k127_6931966_9	745310.G432_08360	1.326e-27	121.0	COG3555@1|root,COG3555@2|Bacteria,1MXZE@1224|Proteobacteria,2U0S2@28211|Alphaproteobacteria,2K0VK@204457|Sphingomonadales	204457|Sphingomonadales	O	Aspartyl/Asparaginyl beta-hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Arg_Hydrox
HFD1_k127_6931966_10	1123267.JONN01000001_gene1988	1.385e-23	103.0	COG3908@1|root,COG3908@2|Bacteria,1N7PA@1224|Proteobacteria,2UFTN@28211|Alphaproteobacteria,2K6ZC@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2093
HFD1_k127_6931966_3	1123267.JONN01000001_gene1989	1.986e-180	580.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,2K05G@204457|Sphingomonadales	204457|Sphingomonadales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HFD1_k127_6931966_2	1123267.JONN01000001_gene1990	6.881e-188	597.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2K0GD@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HFD1_k127_6931966_8	1123267.JONN01000001_gene1993	2.522e-30	126.0	COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2U93Q@28211|Alphaproteobacteria,2KD7J@204457|Sphingomonadales	204457|Sphingomonadales	S	NADH ubiquinone oxidoreductase 41 kD complex I subunit	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
HFD1_k127_6931966_1	1123267.JONN01000001_gene2020	8.579e-202	637.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria,2K087@204457|Sphingomonadales	204457|Sphingomonadales	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HFD1_k127_6931966_7	1123267.JONN01000001_gene2019	3.883e-42	164.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2K074@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
HFD1_k127_6931966_4	1123267.JONN01000001_gene2018	8.006e-67	230.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2U77Q@28211|Alphaproteobacteria,2K4E6@204457|Sphingomonadales	204457|Sphingomonadales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HFD1_k127_6931966_6	745310.G432_05675	5.045e-47	171.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,2K561@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HFD1_k127_6931966_5	1110502.TMO_2217	8.004e-66	231.0	COG2135@1|root,COG2135@2|Bacteria,1MY65@1224|Proteobacteria,2U39X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HFD1_k127_6931966_0	194867.ALBQ01000019_gene3667	2.804e-209	663.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,2JZUK@204457|Sphingomonadales	204457|Sphingomonadales	H	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase)	-	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
HFD1_k127_6950823_3	1123267.JONN01000001_gene1971	3.025e-95	318.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,2K26X@204457|Sphingomonadales	204457|Sphingomonadales	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HFD1_k127_6950823_7	1122604.JONR01000002_gene1619	2.727e-63	226.0	2919Q@1|root,32TZW@2|Bacteria,1Q71M@1224|Proteobacteria,1SIND@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6950823_6	1123267.JONN01000001_gene1975	3.356e-69	243.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U69N@28211|Alphaproteobacteria,2KDKH@204457|Sphingomonadales	204457|Sphingomonadales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,PCMT
HFD1_k127_6950823_2	1123267.JONN01000001_gene575	3.257e-104	353.0	COG1301@1|root,COG1301@2|Bacteria,1MVID@1224|Proteobacteria,2TUR0@28211|Alphaproteobacteria,2K09V@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HFD1_k127_6950823_1	1123267.JONN01000001_gene576	3.264e-109	358.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria,2KD3G@204457|Sphingomonadales	204457|Sphingomonadales	T	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HFD1_k127_6950823_0	1123267.JONN01000001_gene577	1.069e-128	422.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U103@28211|Alphaproteobacteria,2K0W4@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HFD1_k127_6950823_4	1123267.JONN01000001_gene579	9.01e-95	313.0	2AFT8@1|root,315VF@2|Bacteria,1RAPJ@1224|Proteobacteria,2U6M6@28211|Alphaproteobacteria,2K2CZ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6950823_8	1123267.JONN01000001_gene580	2.16e-56	201.0	2D94Q@1|root,32TSM@2|Bacteria,1R37H@1224|Proteobacteria,2TZZ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NT5C
HFD1_k127_6950823_9	1123060.JONP01000004_gene723	3.109e-39	149.0	2C3SB@1|root,33M42@2|Bacteria,1N468@1224|Proteobacteria,2UC0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6950823_5	1123267.JONN01000001_gene582	1.369e-88	297.0	COG0773@1|root,COG0773@2|Bacteria,1MVCG@1224|Proteobacteria,2TTDN@28211|Alphaproteobacteria,2K0S4@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-N-acetylmuramate-alanine ligase	-	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HFD1_k127_6954284_2	629773.AORY01000004_gene310	3.64e-11	67.0	2DNPG@1|root,32YEX@2|Bacteria,1NNRG@1224|Proteobacteria,2UKH6@28211|Alphaproteobacteria,2K45J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6954284_0	1037409.BJ6T_02810	3.924e-318	993.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2TUJ1@28211|Alphaproteobacteria,3JR4S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HFD1_k127_6954284_1	1123267.JONN01000001_gene2189	1.275e-97	320.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria,2JZXW@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HFD1_k127_6959119_0	1280949.HAD_15307	8.513e-278	869.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	X-Pro dipeptidyl-peptidase domain protein	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HFD1_k127_6959119_1	1234595.C725_2265	3.253e-83	281.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,2TSAR@28211|Alphaproteobacteria,4BR9D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	Domain of unknown function (DUF4130	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
HFD1_k127_6959119_2	1403819.BATR01000123_gene4356	1.33e-73	258.0	28KDQ@1|root,2ZA05@2|Bacteria,46VJS@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6959119_3	62928.azo2383	3.966e-37	144.0	COG4659@1|root,COG4659@2|Bacteria,1RFGW@1224|Proteobacteria,2VTI7@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM FMN-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HFD1_k127_6966690_33	279238.Saro_0550	3.692e-22	97.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,2JZZK@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HFD1_k127_6966690_21	1007104.SUS17_2011	4.349e-71	241.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2K4J0@204457|Sphingomonadales	204457|Sphingomonadales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HFD1_k127_6966690_12	1090318.ATTI01000001_gene2784	4.79e-138	449.0	COG3239@1|root,COG3239@2|Bacteria,1MVY5@1224|Proteobacteria,2U156@28211|Alphaproteobacteria,2K0CR@204457|Sphingomonadales	204457|Sphingomonadales	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HFD1_k127_6966690_6	1123267.JONN01000001_gene411	6.466e-172	546.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2K0BS@204457|Sphingomonadales	204457|Sphingomonadales	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6966690_19	1336235.JAEG01000001_gene2164	2.03e-72	263.0	COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,2TUCM@28211|Alphaproteobacteria,4BMA7@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
HFD1_k127_6966690_9	1123267.JONN01000001_gene410	5.374e-149	473.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,2K0HF@204457|Sphingomonadales	204457|Sphingomonadales	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HFD1_k127_6966690_27	237727.NAP1_13083	2.264e-42	159.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria,2K54P@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the HesB IscA family	erpA	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
HFD1_k127_6966690_16	1123267.JONN01000001_gene408	1.339e-110	368.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,2K148@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HFD1_k127_6966690_8	392499.Swit_4686	1.925e-167	535.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,2K0J1@204457|Sphingomonadales	204457|Sphingomonadales	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HFD1_k127_6966690_1	1123267.JONN01000001_gene406	1.99e-251	785.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,2K0J0@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HFD1_k127_6966690_24	246197.MXAN_2136	1.74e-54	209.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,42TQ5@68525|delta/epsilon subdivisions,2WQ0T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_6966690_37	5297.GMQ_07352T0	0.0009906	45.0	COG2072@1|root,KOG1399@2759|Eukaryota,38F1Q@33154|Opisthokonta,3NWM1@4751|Fungi,3V0I8@5204|Basidiomycota,2YDRI@29000|Pucciniomycotina	4751|Fungi	Q	Flavin-binding monooxygenase-like	FMO1	GO:0003674,GO:0003824,GO:0004497,GO:0004499,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0012505,GO:0016020,GO:0016491,GO:0016705,GO:0016709,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0098827	-	-	-	-	-	-	-	-	-	-	FMO-like,NAD_binding_8
HFD1_k127_6966690_18	702113.PP1Y_AT24181	1.11e-75	261.0	COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,2TVSN@28211|Alphaproteobacteria,2K1CP@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_6966690_31	1144307.PMI04_03387	2.445e-25	114.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HFD1_k127_6966690_2	1123267.JONN01000001_gene404	1.373e-239	745.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,2K0T7@204457|Sphingomonadales	204457|Sphingomonadales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HFD1_k127_6966690_32	685035.ADAE01000018_gene807	3.598e-23	102.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2K720@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HFD1_k127_6966690_11	1335760.ASTG01000015_gene3216	1.504e-144	461.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2K0BH@204457|Sphingomonadales	204457|Sphingomonadales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HFD1_k127_6966690_14	1123267.JONN01000001_gene398	2.824e-131	426.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TTN5@28211|Alphaproteobacteria,2K0UY@204457|Sphingomonadales	204457|Sphingomonadales	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HFD1_k127_6966690_13	1123267.JONN01000001_gene397	1.71e-134	436.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,2K1JP@204457|Sphingomonadales	204457|Sphingomonadales	O	molecular chaperone	dnaJ_2	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
HFD1_k127_6966690_17	629773.AORY01000004_gene159	1.597e-84	283.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,2K0J3@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HFD1_k127_6966690_15	1123267.JONN01000001_gene395	3.206e-122	401.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2TT78@28211|Alphaproteobacteria,2K09U@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
HFD1_k127_6966690_23	685778.AORL01000021_gene1003	1.719e-55	198.0	COG4319@1|root,COG4319@2|Bacteria,1RDBF@1224|Proteobacteria,2U7AM@28211|Alphaproteobacteria,2K4U6@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_6966690_7	629773.AORY01000002_gene1460	4.915e-171	543.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TTTV@28211|Alphaproteobacteria,2K296@204457|Sphingomonadales	204457|Sphingomonadales	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HFD1_k127_6966690_25	13689.BV96_01501	2.829e-50	185.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,2U8N1@28211|Alphaproteobacteria,2K5NT@204457|Sphingomonadales	204457|Sphingomonadales	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD1_k127_6966690_5	1123267.JONN01000001_gene392	7.841e-178	563.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,2K1HV@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HFD1_k127_6966690_26	1174684.EBMC1_00345	2.692e-48	173.0	2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,2K54G@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1153
HFD1_k127_6966690_28	1131451.O1K_11700	6.38e-31	124.0	COG2261@1|root,COG2261@2|Bacteria,1NAHZ@1224|Proteobacteria,1T0FB@1236|Gammaproteobacteria,1X82B@135614|Xanthomonadales	135614|Xanthomonadales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD1_k127_6966690_20	745310.G432_10495	3.773e-72	250.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2K40S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HFD1_k127_6966690_29	1123267.JONN01000001_gene388	1.36e-28	117.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2UBU4@28211|Alphaproteobacteria,2K6WX@204457|Sphingomonadales	204457|Sphingomonadales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HFD1_k127_6966690_10	1123267.JONN01000001_gene387	6.912e-149	481.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2U18A@28211|Alphaproteobacteria,2K0EM@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HFD1_k127_6966690_0	1123267.JONN01000001_gene386	0.0	1311.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K0BI@204457|Sphingomonadales	204457|Sphingomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HFD1_k127_6966690_4	1123267.JONN01000001_gene385	7.736e-188	594.0	COG2733@1|root,COG2733@2|Bacteria,1MX3G@1224|Proteobacteria,2U15J@28211|Alphaproteobacteria,2K0FY@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HFD1_k127_6966690_34	1536775.H70737_20780	1.063e-14	84.0	COG0454@1|root,COG0456@2|Bacteria,1VAKJ@1239|Firmicutes,4HKQM@91061|Bacilli,26TTU@186822|Paenibacillaceae	91061|Bacilli	K	Histone acetyltransferase	cML1	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
HFD1_k127_6966690_3	1123267.JONN01000001_gene377	3.004e-226	706.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,2K1H1@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HFD1_k127_6966690_22	1123267.JONN01000001_gene378	1.312e-55	196.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2K5BT@204457|Sphingomonadales	204457|Sphingomonadales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HFD1_k127_6970643_9	1234595.C725_1413	1.335e-18	85.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,4BQFZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HFD1_k127_6970643_12	1340434.AXVA01000004_gene2611	0.0009029	50.0	28P7V@1|root,2ZC22@2|Bacteria,1V2CT@1239|Firmicutes,4HG6A@91061|Bacilli,1ZCF8@1386|Bacillus	91061|Bacilli	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF1835,DUF3658
HFD1_k127_6970643_4	1336243.JAEA01000005_gene1559	4.189e-74	262.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,1JX36@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD1_k127_6970643_5	1234595.C725_0245	1.818e-68	241.0	COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,2TWB5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Erythro_esteras,PCMT,Pribosyltran
HFD1_k127_6970643_2	450851.PHZ_c3225	3.304e-183	582.0	COG2312@1|root,COG2312@2|Bacteria,1MU2S@1224|Proteobacteria,2TY7R@28211|Alphaproteobacteria,2KHES@204458|Caulobacterales	204458|Caulobacterales	S	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	DLH,Erythro_esteras,Pribosyltran
HFD1_k127_6970643_6	159450.NH14_07855	2.041e-51	185.0	COG4319@1|root,COG4319@2|Bacteria,1RII1@1224|Proteobacteria,2VXCZ@28216|Betaproteobacteria,1K8QB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_6970643_11	1041139.KB902624_gene5829	2.245e-08	57.0	COG3729@1|root,COG3729@2|Bacteria,1NH1J@1224|Proteobacteria,2V3CC@28211|Alphaproteobacteria,4BKFC@82115|Rhizobiaceae	1224|Proteobacteria	S	Stress-induced bacterial acidophilic repeat motif	-	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	KGG
HFD1_k127_6970643_0	1123267.JONN01000001_gene1585	1.819e-300	935.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2K0EY@204457|Sphingomonadales	204457|Sphingomonadales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HFD1_k127_6970643_3	1292034.OR37_01135	3.673e-168	546.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2U19S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HFD1_k127_6970643_1	1123267.JONN01000001_gene1668	1.113e-218	687.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales	204457|Sphingomonadales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HFD1_k127_6970643_7	1123267.JONN01000001_gene1635	4.341e-40	150.0	COG3255@1|root,COG3255@2|Bacteria,1Q4V4@1224|Proteobacteria,2VB9X@28211|Alphaproteobacteria,2K6UF@204457|Sphingomonadales	204457|Sphingomonadales	I	PFAM Sterol-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HFD1_k127_6970643_8	1248917.ANFX01000029_gene2637	7.935e-20	102.0	COG3602@1|root,COG3602@2|Bacteria,1MZKQ@1224|Proteobacteria,2U85U@28211|Alphaproteobacteria,2KDC5@204457|Sphingomonadales	204457|Sphingomonadales	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT_3,ACT_7
HFD1_k127_6970643_10	1123073.KB899244_gene351	2.922e-11	67.0	COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,1SAKR@1236|Gammaproteobacteria,1XATQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_6986824_1	1123267.JONN01000001_gene424	2.296e-123	409.0	COG1597@1|root,COG1597@2|Bacteria,1R78V@1224|Proteobacteria,2U0V0@28211|Alphaproteobacteria,2K03G@204457|Sphingomonadales	204457|Sphingomonadales	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HFD1_k127_6986824_0	1123267.JONN01000001_gene423	1.12e-159	518.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2U55Q@28211|Alphaproteobacteria,2K07C@204457|Sphingomonadales	204457|Sphingomonadales	S	YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HFD1_k127_6986824_2	1123267.JONN01000001_gene422	5.369e-122	408.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,2K1ZM@204457|Sphingomonadales	204457|Sphingomonadales	S	YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HFD1_k127_6986824_4	1123267.JONN01000001_gene951	5.969e-46	166.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,2UCEY@28211|Alphaproteobacteria,2K7ZX@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HFD1_k127_6986824_3	1057002.KB905370_gene2611	2.835e-92	319.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
HFD1_k127_705260_0	1123267.JONN01000001_gene1794	0.0	1100.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,2K02F@204457|Sphingomonadales	204457|Sphingomonadales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
HFD1_k127_705260_9	392499.Swit_4693	6.979e-51	190.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,2KCZI@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HFD1_k127_705260_8	1123267.JONN01000001_gene1793	5.325e-55	201.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,2KCZI@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HFD1_k127_705260_7	1123267.JONN01000001_gene1792	9.146e-63	221.0	COG5389@1|root,COG5389@2|Bacteria,1N82D@1224|Proteobacteria,2UFA9@28211|Alphaproteobacteria,2K4U1@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HFD1_k127_705260_3	1123267.JONN01000001_gene1791	4.584e-120	396.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,2K0ZZ@204457|Sphingomonadales	204457|Sphingomonadales	L	glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HFD1_k127_705260_4	1123267.JONN01000001_gene1790	1.499e-90	308.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,2K1ZX@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HFD1_k127_705260_5	745310.G432_02635	7.79e-82	278.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,2K42S@204457|Sphingomonadales	204457|Sphingomonadales	C	cytochrome C	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HFD1_k127_705260_2	1123267.JONN01000001_gene1787	1.87e-136	439.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,2K00V@204457|Sphingomonadales	204457|Sphingomonadales	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HFD1_k127_705260_1	1219035.NT2_02_01140	2.628e-148	482.0	COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,2TVJ2@28211|Alphaproteobacteria,2K3GA@204457|Sphingomonadales	204457|Sphingomonadales	V	Inner membrane protein CreD	-	-	-	-	-	-	-	-	-	-	-	-	CreD
HFD1_k127_705260_6	1123267.JONN01000001_gene1850	2.7e-79	266.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2TSR6@28211|Alphaproteobacteria,2K0PN@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HFD1_k127_7097480_2	1123267.JONN01000001_gene676	1.682e-177	560.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,2K18V@204457|Sphingomonadales	204457|Sphingomonadales	C	Transketolase, thiamine diphosphate binding domain	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N
HFD1_k127_7097480_6	1234595.C725_0615	8.465e-75	263.0	COG0500@1|root,COG2226@2|Bacteria,1N7M1@1224|Proteobacteria,2UFS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD1_k127_7097480_7	1123267.JONN01000001_gene677	6.365e-56	198.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,2UC19@28211|Alphaproteobacteria,2K6D3@204457|Sphingomonadales	204457|Sphingomonadales	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HFD1_k127_7097480_5	1123267.JONN01000001_gene678	1.618e-75	261.0	COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2U8Z1@28211|Alphaproteobacteria,2K4NI@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
HFD1_k127_7097480_8	555793.WSK_1788	6.633e-28	116.0	2DD18@1|root,2ZG4B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7097480_4	936455.KI421499_gene4476	2.126e-157	502.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2TUG0@28211|Alphaproteobacteria,3JW8S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HFD1_k127_7097480_3	1123267.JONN01000001_gene681	1.138e-174	557.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2TS31@28211|Alphaproteobacteria,2K1MM@204457|Sphingomonadales	204457|Sphingomonadales	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	bkdB	-	2.3.1.168	ko:K09699	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R02662,R03174,R04097,R10998	RC00004,RC02727,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_7097480_1	1123267.JONN01000001_gene682	1.4e-192	608.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2K02S@204457|Sphingomonadales	204457|Sphingomonadales	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HFD1_k127_7097480_0	1123267.JONN01000001_gene683	5.103e-210	659.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TSEI@28211|Alphaproteobacteria,2K13V@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh,OxoDH_E1alpha_N
HFD1_k127_7097480_9	743721.Psesu_2678	1.872e-06	49.0	2CC0C@1|root,32ZJ1@2|Bacteria,1R3EF@1224|Proteobacteria,1T671@1236|Gammaproteobacteria,1X7I1@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3297)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3297
HFD1_k127_7145631_2	1123267.JONN01000001_gene556	3.351e-88	296.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,2K122@204457|Sphingomonadales	204457|Sphingomonadales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HFD1_k127_7145631_4	1123267.JONN01000001_gene1457	4.763e-58	211.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HFD1_k127_7145631_1	1123267.JONN01000001_gene1456	4.375e-97	326.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HFD1_k127_7145631_0	1219049.SP5_024_00190	8.064e-162	512.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria,2K1RK@204457|Sphingomonadales	204457|Sphingomonadales	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HFD1_k127_7145631_3	1379701.JPJC01000258_gene2699	3.211e-85	290.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,2K16M@204457|Sphingomonadales	204457|Sphingomonadales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HFD1_k127_715537_0	1123267.JONN01000001_gene968	1.098e-99	327.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria,2K17V@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HFD1_k127_715537_1	394221.Mmar10_1812	4.919e-83	295.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,43WYB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8
HFD1_k127_715659_0	296591.Bpro_1194	6.989e-147	474.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2VHXI@28216|Betaproteobacteria,4AB63@80864|Comamonadaceae	28216|Betaproteobacteria	F	thymidine phosphorylase	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HFD1_k127_715659_1	1411123.JQNH01000001_gene530	2.803e-85	292.0	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2U3AB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
HFD1_k127_715659_2	509190.Cseg_0103	2.282e-61	218.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2KF5V@204458|Caulobacterales	204458|Caulobacterales	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HFD1_k127_7237377_24	1030157.AFMP01000044_gene1741	5.777e-23	108.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2K0C4@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HFD1_k127_7237377_1	1007104.SUS17_2642	1.808e-201	647.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2TRWD@28211|Alphaproteobacteria,2JZVN@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0729 Outer membrane protein	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA
HFD1_k127_7237377_25	1123267.JONN01000001_gene1025	7.387e-21	94.0	2A2WA@1|root,30RAD@2|Bacteria,1NY8N@1224|Proteobacteria,2USY9@28211|Alphaproteobacteria,2K6VV@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7237377_17	1030157.AFMP01000044_gene1812	6.997e-76	259.0	COG2932@1|root,COG2932@2|Bacteria,1N97M@1224|Proteobacteria,2UF88@28211|Alphaproteobacteria,2K4JZ@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
HFD1_k127_7237377_26	1030157.AFMP01000044_gene1811	3.546e-16	79.0	2BMMB@1|root,32G6F@2|Bacteria,1NPK2@1224|Proteobacteria,2UKR9@28211|Alphaproteobacteria,2K7TJ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7237377_19	1114964.L485_10070	9.967e-63	221.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,2K4S9@204457|Sphingomonadales	204457|Sphingomonadales	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HFD1_k127_7237377_7	1123267.JONN01000001_gene1019	5.396e-123	402.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,2TUAH@28211|Alphaproteobacteria,2JZW2@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA topoisomerase	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HFD1_k127_7237377_11	1123267.JONN01000001_gene1018	4.947e-100	336.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2TV9F@28211|Alphaproteobacteria,2K1C9@204457|Sphingomonadales	204457|Sphingomonadales	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HFD1_k127_7237377_18	1123267.JONN01000001_gene1014	5.31e-63	222.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2U9GG@28211|Alphaproteobacteria,2K4IV@204457|Sphingomonadales	204457|Sphingomonadales	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD1_k127_7237377_3	1248917.ANFX01000041_gene1724	8.261e-199	626.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K0V0@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HFD1_k127_7237377_21	745310.G432_16195	8.912e-49	188.0	2E2RM@1|root,32XU3@2|Bacteria,1P05E@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7237377_12	685778.AORL01000022_gene1441	3.254e-99	330.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,2K2F3@204457|Sphingomonadales	204457|Sphingomonadales	O	COG0330 Membrane protease subunits, stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HFD1_k127_7237377_22	1335760.ASTG01000001_gene2886	5.854e-24	107.0	2AM08@1|root,31BTY@2|Bacteria,1NYJI@1224|Proteobacteria,2VGXW@28211|Alphaproteobacteria,2K6BP@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7237377_4	1123267.JONN01000001_gene1009	1.777e-170	547.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,2TT27@28211|Alphaproteobacteria,2K3H0@204457|Sphingomonadales	204457|Sphingomonadales	EGP	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HFD1_k127_7237377_2	1081640.AGFU01000025_gene2552	3.112e-201	634.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,2K1W9@204457|Sphingomonadales	204457|Sphingomonadales	I	de-polymerase	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
HFD1_k127_7237377_5	1057002.KB905370_gene2377	2.647e-155	516.0	COG0076@1|root,COG0454@1|root,COG0076@2|Bacteria,COG0454@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,4B92C@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	decarboxylase	rhbB	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HFD1_k127_7237377_0	1030157.AFMP01000044_gene1801	2.319e-257	805.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0VT@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HFD1_k127_7237377_27	1112212.JH584235_gene3325	8.426e-16	88.0	2BR2H@1|root,32K09@2|Bacteria,1NW9X@1224|Proteobacteria,2US0J@28211|Alphaproteobacteria,2K5FU@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7237377_20	1123267.JONN01000002_gene46	7.069e-60	219.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2K0W5@204457|Sphingomonadales	204457|Sphingomonadales	S	synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HFD1_k127_7237377_16	1219049.SP5_016_00260	4.003e-84	291.0	COG3243@1|root,COG3243@2|Bacteria,1Q6YK@1224|Proteobacteria,2TTVK@28211|Alphaproteobacteria,2K26F@204457|Sphingomonadales	204457|Sphingomonadales	I	COG3243 Poly(3-hydroxyalkanoate) synthetase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_6
HFD1_k127_7237377_29	441620.Mpop_5133	2.617e-06	53.0	COG1961@1|root,COG1961@2|Bacteria,1PWCY@1224|Proteobacteria,2TVME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HFD1_k127_7237377_15	1121033.AUCF01000003_gene3135	8.151e-91	305.0	2DB86@1|root,2Z7QD@2|Bacteria,1MX4S@1224|Proteobacteria,2TTA6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HFD1_k127_7237377_10	1123269.NX02_08470	7.647e-103	342.0	COG2129@1|root,COG2129@2|Bacteria,1MVNK@1224|Proteobacteria,2U1YV@28211|Alphaproteobacteria,2K32D@204457|Sphingomonadales	204457|Sphingomonadales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HFD1_k127_7237377_6	685778.AORL01000025_gene49	3.368e-144	464.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2TT52@28211|Alphaproteobacteria,2K3EY@204457|Sphingomonadales	204457|Sphingomonadales	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HFD1_k127_7237377_9	1007105.PT7_1069	5.372e-107	357.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,3T2NW@506|Alcaligenaceae	28216|Betaproteobacteria	P	sulfate transport system, permease	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
HFD1_k127_7237377_8	1122604.JONR01000005_gene926	3.682e-118	387.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,1RNZK@1236|Gammaproteobacteria,1X4I5@135614|Xanthomonadales	135614|Xanthomonadales	P	Part of the ABC transporter complex cysAWTP involved in sulfate thiosulfate import	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HFD1_k127_7237377_13	685778.AORL01000025_gene53	1.057e-97	329.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2TVZ3@28211|Alphaproteobacteria,2KENV@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran
HFD1_k127_7237377_14	1123267.JONN01000002_gene29	1.05e-91	304.0	COG0508@1|root,COG0508@2|Bacteria,1R0J5@1224|Proteobacteria,2U28K@28211|Alphaproteobacteria,2K8XE@204457|Sphingomonadales	204457|Sphingomonadales	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HFD1_k127_7267892_6	1123267.JONN01000001_gene924	7.298e-73	252.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2U8@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HFD1_k127_7267892_0	1123267.JONN01000001_gene925	7.864e-256	795.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2K0CG@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HFD1_k127_7267892_4	1123267.JONN01000001_gene926	1.687e-152	490.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,2K17G@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
HFD1_k127_7267892_7	1123267.JONN01000001_gene927	2.26e-35	141.0	COG3063@1|root,COG3063@2|Bacteria,1R17W@1224|Proteobacteria,2TYY0@28211|Alphaproteobacteria,2KEPF@204457|Sphingomonadales	204457|Sphingomonadales	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
HFD1_k127_7267892_5	1123267.JONN01000001_gene928	2.447e-119	389.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,2K042@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HFD1_k127_7267892_3	1123267.JONN01000001_gene929	4.822e-158	503.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2K0HZ@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HFD1_k127_7267892_1	1123267.JONN01000001_gene930	7.752e-179	571.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,2K0UR@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidylprolyl isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
HFD1_k127_7267892_2	1123267.JONN01000001_gene931	1.759e-177	562.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,2K1GQ@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
HFD1_k127_7279823_7	1219049.SP5_035_00510	5.896e-23	98.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,2K3F8@204457|Sphingomonadales	204457|Sphingomonadales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HFD1_k127_7279823_6	1081640.AGFU01000082_gene3435	1.421e-28	121.0	COG1051@1|root,COG1051@2|Bacteria,1N0YW@1224|Proteobacteria,2UC2E@28211|Alphaproteobacteria,2K6G9@204457|Sphingomonadales	204457|Sphingomonadales	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HFD1_k127_7279823_0	158500.BV97_02672	7.438e-109	359.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2K0KF@204457|Sphingomonadales	204457|Sphingomonadales	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HFD1_k127_7279823_3	161528.ED21_20779	5.544e-59	211.0	2FGC9@1|root,3488G@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
HFD1_k127_7279823_2	291985.CCSI01000007_gene460	6.742e-70	254.0	28M5H@1|root,2ZAJ9@2|Bacteria,1RJY2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7279823_1	161528.ED21_20789	3.703e-101	342.0	COG0639@1|root,COG0639@2|Bacteria,1QEIM@1224|Proteobacteria,2UUEK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein phosphatase 2A homologues, catalytic domain.	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HFD1_k127_7279823_4	530564.Psta_0527	1.398e-51	197.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_7279823_5	1207055.C100_01830	6.015e-43	162.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,2K14K@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
HFD1_k127_7327013_4	1123267.JONN01000001_gene1287	1.27e-84	283.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,2K1AX@204457|Sphingomonadales	204457|Sphingomonadales	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HFD1_k127_7327013_2	1123267.JONN01000001_gene1285	4.407e-145	482.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria,2K0KV@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
HFD1_k127_7327013_3	1123267.JONN01000001_gene1284	1.711e-85	289.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,2K1PI@204457|Sphingomonadales	204457|Sphingomonadales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HFD1_k127_7327013_6	1123267.JONN01000001_gene1283	4.543e-27	114.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,2K5YU@204457|Sphingomonadales	204457|Sphingomonadales	U	Preprotein translocase subunit SecG	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HFD1_k127_7327013_0	1123267.JONN01000001_gene1282	1.705e-303	935.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,2K005@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HFD1_k127_7327013_7	1088721.NSU_3708	1.557e-08	57.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7327013_1	1123267.JONN01000001_gene1276	5.612e-166	526.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,2K0I2@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HFD1_k127_7327013_5	13689.BV96_04238	1.299e-74	265.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TUK2@28211|Alphaproteobacteria,2K0RW@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD1_k127_7337786_1	1537715.JQFJ01000002_gene279	1.242e-45	173.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,2K4IY@204457|Sphingomonadales	204457|Sphingomonadales	CO	Alkyl hydroperoxide reductase	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
HFD1_k127_7337786_0	1123267.JONN01000001_gene1136	1.217e-252	792.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,2K1MA@204457|Sphingomonadales	204457|Sphingomonadales	O	cytochrome C	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HFD1_k127_7348843_5	1123267.JONN01000001_gene1395	3.955e-31	124.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,2K0N6@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HFD1_k127_7348843_4	113395.AXAI01000014_gene218	1.031e-41	159.0	COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria,3K009@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2,Cupin_7,DUF4437
HFD1_k127_7348843_0	685778.AORL01000016_gene2296	5.654e-238	752.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,2K1BA@204457|Sphingomonadales	204457|Sphingomonadales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HFD1_k127_7348843_3	1123267.JONN01000001_gene1389	8.744e-115	375.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,2K080@204457|Sphingomonadales	204457|Sphingomonadales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HFD1_k127_7348843_2	1123267.JONN01000001_gene1388	6.278e-130	419.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,2K2A5@204457|Sphingomonadales	204457|Sphingomonadales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HFD1_k127_7348843_6	1122970.AUHC01000013_gene1088	4.069e-28	116.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,2K617@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HFD1_k127_7348843_1	1030157.AFMP01000031_gene2866	9.271e-131	428.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,2JZZ0@204457|Sphingomonadales	204457|Sphingomonadales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HFD1_k127_7352990_3	1123267.JONN01000002_gene252	2.495e-88	293.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,2K104@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HFD1_k127_7352990_5	392499.Swit_2665	4.243e-57	203.0	COG3791@1|root,COG3791@2|Bacteria,1RE8S@1224|Proteobacteria,2U73V@28211|Alphaproteobacteria,2K4NT@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HFD1_k127_7352990_2	1120705.FG95_03459	2.204e-94	317.0	COG2267@1|root,COG2267@2|Bacteria,1QUNU@1224|Proteobacteria,2TW29@28211|Alphaproteobacteria,2K09G@204457|Sphingomonadales	204457|Sphingomonadales	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HFD1_k127_7352990_4	1123267.JONN01000001_gene1046	1.48e-78	266.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,2K3WE@204457|Sphingomonadales	204457|Sphingomonadales	O	Alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HFD1_k127_7352990_1	1123267.JONN01000001_gene1047	2.247e-99	336.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,2K3S2@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HFD1_k127_7352990_6	1123267.JONN01000001_gene1201	1.182e-51	194.0	COG5592@1|root,COG5592@2|Bacteria,1N6KG@1224|Proteobacteria,2UCBE@28211|Alphaproteobacteria,2K1MZ@204457|Sphingomonadales	204457|Sphingomonadales	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HFD1_k127_7352990_0	1123267.JONN01000001_gene1202	1.144e-123	403.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,2K0ZN@204457|Sphingomonadales	204457|Sphingomonadales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HFD1_k127_7366736_14	1174684.EBMC1_09479	6.646e-39	147.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales	204457|Sphingomonadales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HFD1_k127_7366736_11	1123267.JONN01000001_gene767	3.97e-54	197.0	2E21J@1|root,32X9B@2|Bacteria,1N5A7@1224|Proteobacteria,2UF1K@28211|Alphaproteobacteria,2K5FT@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4893)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4893
HFD1_k127_7366736_5	1123267.JONN01000001_gene768	1.22e-116	380.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,2K16P@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HFD1_k127_7366736_6	1123267.JONN01000001_gene769	7.171e-101	337.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2TRCS@28211|Alphaproteobacteria,2K20W@204457|Sphingomonadales	204457|Sphingomonadales	S	metalloprotease	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HFD1_k127_7366736_3	1123267.JONN01000001_gene770	7.984e-141	454.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2K21X@204457|Sphingomonadales	204457|Sphingomonadales	L	alcohol dehydrogenase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HFD1_k127_7366736_12	685778.AORL01000019_gene1786	4.926e-49	191.0	COG3798@1|root,COG3798@2|Bacteria,1N0BJ@1224|Proteobacteria,2UDJF@28211|Alphaproteobacteria,2KE5H@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
HFD1_k127_7366736_15	1229204.AMYY01000002_gene2594	4.953e-35	140.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
HFD1_k127_7366736_7	1449049.JONW01000010_gene3729	2.219e-91	313.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HFD1_k127_7366736_1	685778.AORL01000022_gene1304	0.0	1158.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,2K0IJ@204457|Sphingomonadales	204457|Sphingomonadales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HFD1_k127_7366736_13	1219045.BV98_000330	1.084e-41	154.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,2K622@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HFD1_k127_7366736_4	1123267.JONN01000001_gene786	1.649e-118	388.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2K00T@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HFD1_k127_7366736_9	1090319.KE386571_gene1300	1.666e-78	269.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2TRIF@28211|Alphaproteobacteria,2K3J2@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HFD1_k127_7366736_10	1346791.M529_18085	3.453e-58	210.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria,2K4FV@204457|Sphingomonadales	204457|Sphingomonadales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HFD1_k127_7366736_0	1123267.JONN01000001_gene792	0.0	1207.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,2K1X7@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
HFD1_k127_7366736_8	1123267.JONN01000001_gene793	4.644e-80	274.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,2K2B7@204457|Sphingomonadales	204457|Sphingomonadales	K	Nucleic-acid-binding protein	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HFD1_k127_7366736_2	1123267.JONN01000001_gene794	6.973e-165	522.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,2K1KF@204457|Sphingomonadales	204457|Sphingomonadales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HFD1_k127_7374665_0	1123267.JONN01000001_gene1030	1.664e-262	811.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,2K06N@204457|Sphingomonadales	204457|Sphingomonadales	E	highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HFD1_k127_7374665_1	1123267.JONN01000001_gene1027	9.114e-186	591.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria,2K03C@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HFD1_k127_7374665_2	1030157.AFMP01000044_gene1741	2.975e-83	279.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2K0C4@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HFD1_k127_7381043_2	1123267.JONN01000001_gene539	8.625e-92	308.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria,2K28T@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HFD1_k127_7381043_8	1207055.C100_23685	2.775e-13	80.0	2BJGF@1|root,32DT8@2|Bacteria,1NRPG@1224|Proteobacteria,2UPT5@28211|Alphaproteobacteria,2K7DE@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
HFD1_k127_7381043_4	1030157.AFMP01000062_gene3529	7.543e-69	242.0	COG0454@1|root,COG0454@2|Bacteria,1RDGT@1224|Proteobacteria,2TRF5@28211|Alphaproteobacteria,2K22G@204457|Sphingomonadales	204457|Sphingomonadales	K	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HFD1_k127_7381043_0	1081640.AGFU01000082_gene3416	4.447e-138	443.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria,2K084@204457|Sphingomonadales	204457|Sphingomonadales	H	coproporphyrinogen III oxidase	hemF	-	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HFD1_k127_7381043_7	1123267.JONN01000001_gene1032	8.381e-28	113.0	2B3XE@1|root,31WMD@2|Bacteria,1P4DI@1224|Proteobacteria,2UW3Y@28211|Alphaproteobacteria,2KBX1@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phage_CI_repr
HFD1_k127_7381043_6	1123267.JONN01000001_gene1033	3.228e-54	197.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,2K4IQ@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HFD1_k127_7381043_1	1123267.JONN01000001_gene1034	5.496e-102	338.0	COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,2U5XC@28211|Alphaproteobacteria,2K2S2@204457|Sphingomonadales	204457|Sphingomonadales	M	Nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
HFD1_k127_7381043_3	1297865.APJD01000015_gene3469	3.552e-79	270.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3JSHJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Thioesterase
HFD1_k127_7381043_5	279238.Saro_3301	1.387e-57	201.0	COG0824@1|root,COG0824@2|Bacteria,1RHB1@1224|Proteobacteria,2UATC@28211|Alphaproteobacteria,2K4SF@204457|Sphingomonadales	204457|Sphingomonadales	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,Acyl-ACP_TE
HFD1_k127_7381916_2	1123267.JONN01000001_gene1758	6.952e-108	359.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,2K19R@204457|Sphingomonadales	204457|Sphingomonadales	GM	Dehydrogenase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
HFD1_k127_7381916_1	194867.ALBQ01000021_gene1888	3.132e-111	367.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,2K0R1@204457|Sphingomonadales	204457|Sphingomonadales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HFD1_k127_7381916_0	1123267.JONN01000001_gene1824	9.738e-124	402.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,2K1DG@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HFD1_k127_7381916_4	1123270.ATUR01000008_gene233	2.128e-11	65.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,2K0DH@204457|Sphingomonadales	204457|Sphingomonadales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HFD1_k127_7393762_25	702113.PP1Y_AT664	1.401e-71	247.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2K0GR@204457|Sphingomonadales	204457|Sphingomonadales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HFD1_k127_7393762_27	1090318.ATTI01000001_gene517	9.822e-55	197.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,2K4K3@204457|Sphingomonadales	204457|Sphingomonadales	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HFD1_k127_7393762_30	1123267.JONN01000001_gene1748	5.347e-32	129.0	2C068@1|root,30N9J@2|Bacteria,1RG08@1224|Proteobacteria,2U9FG@28211|Alphaproteobacteria,2K56D@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3035)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3035
HFD1_k127_7393762_20	1123267.JONN01000001_gene1747	4.283e-84	282.0	COG0745@1|root,COG0745@2|Bacteria	1123267.JONN01000001_gene1747|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7393762_17	1123267.JONN01000001_gene1745	7.648e-107	353.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,2K1GF@204457|Sphingomonadales	204457|Sphingomonadales	P	Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HFD1_k127_7393762_15	745310.G432_17370	1.856e-118	385.0	COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,2U1VI@28211|Alphaproteobacteria,2K0CQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD1_k127_7393762_23	1174684.EBMC1_05744	3.82e-80	274.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2U57X@28211|Alphaproteobacteria,2K3W2@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HFD1_k127_7393762_24	1217703.F904_01972	6.629e-80	280.0	COG1893@1|root,COG1893@2|Bacteria,1N0M5@1224|Proteobacteria,1RNZY@1236|Gammaproteobacteria,3NM1M@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HFD1_k127_7393762_2	1123267.JONN01000001_gene1743	2.662e-276	864.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2TRCZ@28211|Alphaproteobacteria,2K1RU@204457|Sphingomonadales	204457|Sphingomonadales	S	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HFD1_k127_7393762_37	1297742.A176_00926	0.0009782	49.0	2DDIE@1|root,2ZI7X@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HFD1_k127_7393762_34	745310.G432_09745	1.222e-13	81.0	2AI6K@1|root,318KX@2|Bacteria,1P1HA@1224|Proteobacteria,2UV4H@28211|Alphaproteobacteria,2K74P@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7393762_8	266835.14028141	1.992e-139	449.0	28QIE@1|root,2ZD0E@2|Bacteria,1NR13@1224|Proteobacteria,2UQ53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7393762_5	745310.G432_09735	1.814e-181	582.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2K08H@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HFD1_k127_7393762_11	1123267.JONN01000001_gene414	6.589e-122	399.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,2K1HR@204457|Sphingomonadales	204457|Sphingomonadales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HFD1_k127_7393762_16	745310.G432_09725	6.633e-117	393.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2K20N@204457|Sphingomonadales	204457|Sphingomonadales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HFD1_k127_7393762_14	1123267.JONN01000001_gene416	1.342e-119	392.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,2K1RH@204457|Sphingomonadales	204457|Sphingomonadales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
HFD1_k127_7393762_26	745310.G432_09715	4.456e-67	235.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2TUIY@28211|Alphaproteobacteria,2K4FQ@204457|Sphingomonadales	204457|Sphingomonadales	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HFD1_k127_7393762_6	745310.G432_11815	8.067e-155	500.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2K048@204457|Sphingomonadales	204457|Sphingomonadales	S	modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HFD1_k127_7393762_10	1123267.JONN01000001_gene419	4.213e-123	405.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,2K0XU@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HFD1_k127_7393762_22	1123267.JONN01000001_gene1836	3.764e-83	282.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria,2K0TB@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HFD1_k127_7393762_3	1123269.NX02_23545	1.375e-224	703.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2K1IW@204457|Sphingomonadales	204457|Sphingomonadales	H	glutamate--cysteine ligase	-	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
HFD1_k127_7393762_7	1120792.JAFV01000001_gene3721	6.384e-140	451.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2TVXS@28211|Alphaproteobacteria,36XS6@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	pipch2	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HFD1_k127_7393762_1	1123267.JONN01000001_gene1480	8.9e-322	1001.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2K1S8@204457|Sphingomonadales	204457|Sphingomonadales	S	COG2366 Protein related to penicillin acylase	-	-	-	-	-	-	-	-	-	-	-	-	Penicil_amidase
HFD1_k127_7393762_0	1123267.JONN01000001_gene1839	0.0	1189.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2K046@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HFD1_k127_7393762_12	1123267.JONN01000001_gene1840	7.603e-121	394.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2TRTI@28211|Alphaproteobacteria,2K1JG@204457|Sphingomonadales	204457|Sphingomonadales	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HFD1_k127_7393762_21	1123267.JONN01000001_gene2363	2.036e-83	285.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,2K0XH@204457|Sphingomonadales	204457|Sphingomonadales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HFD1_k127_7393762_4	1123267.JONN01000001_gene2362	1.577e-185	586.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,2K1IA@204457|Sphingomonadales	204457|Sphingomonadales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_7393762_9	1123267.JONN01000001_gene2361	1.529e-126	421.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria,2K0PS@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HFD1_k127_7393762_18	382245.ASA_1405	9.826e-91	311.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1Y3M8@135624|Aeromonadales	135624|Aeromonadales	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HFD1_k127_7393762_32	392499.Swit_3181	4.371e-24	109.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282,ko:K07782,ko:K19135	ko02020,ko02024,ko02026,map02020,map02024,map02026	-	-	-	ko00000,ko00001,ko02035,ko02044,ko02048,ko03000	-	-	-	Cas_NE0113,GerE,Response_reg,TPR_16
HFD1_k127_7393762_33	1379701.JPJC01000161_gene951	1.662e-19	98.0	2EP5S@1|root,33GSG@2|Bacteria,1NI0K@1224|Proteobacteria,2UK2B@28211|Alphaproteobacteria,2K7KA@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7393762_13	1123267.JONN01000001_gene1825	1.224e-120	394.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,2K163@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HFD1_k127_7393762_19	1123267.JONN01000001_gene1826	5.458e-87	293.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria,2K0I0@204457|Sphingomonadales	204457|Sphingomonadales	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HFD1_k127_7393762_28	1123267.JONN01000001_gene1850	2.526e-52	187.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2TSR6@28211|Alphaproteobacteria,2K0PN@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HFD1_k127_7454377_3	629773.AORY01000004_gene552	5.241e-80	268.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,2K25A@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HFD1_k127_7454377_1	1248916.ANFY01000017_gene1427	1.466e-99	345.0	COG1680@1|root,COG1680@2|Bacteria,1R8N7@1224|Proteobacteria,2UCNR@28211|Alphaproteobacteria,2K0VY@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HFD1_k127_7454377_7	1331060.RLDS_08150	1.072e-20	96.0	2AKTW@1|root,31BKY@2|Bacteria,1NYMF@1224|Proteobacteria,2UTU9@28211|Alphaproteobacteria,2K5IB@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7454377_5	1123267.JONN01000001_gene436	6.538e-42	166.0	COG3225@1|root,COG3225@2|Bacteria,1NC9C@1224|Proteobacteria,2UH50@28211|Alphaproteobacteria,2K6BU@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
HFD1_k127_7454377_4	1123267.JONN01000001_gene437	5.776e-72	247.0	COG2001@1|root,COG2001@2|Bacteria,1RC62@1224|Proteobacteria,2U8RU@28211|Alphaproteobacteria,2K3M2@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the MraZ family	-	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HFD1_k127_7454377_0	392499.Swit_3955	1.481e-119	399.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,2K178@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HFD1_k127_7454377_6	1123267.JONN01000001_gene439	2.875e-33	138.0	2AK00@1|root,31APD@2|Bacteria,1NHHT@1224|Proteobacteria,2UM7C@28211|Alphaproteobacteria,2K3BJ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7454377_2	1123267.JONN01000001_gene440	1.717e-99	331.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,2K0Y2@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell division protein FtsI penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HFD1_k127_7474876_3	1123267.JONN01000001_gene2229	6.049e-135	432.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,2K052@204457|Sphingomonadales	204457|Sphingomonadales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HFD1_k127_7474876_5	1214101.BN159_0538	4.691e-42	158.0	COG2329@1|root,COG2329@2|Bacteria,2I6PF@201174|Actinobacteria	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7474876_2	1123267.JONN01000001_gene2234	1.282e-147	474.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,2K0WV@204457|Sphingomonadales	204457|Sphingomonadales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HFD1_k127_7474876_1	1550073.JROH01000035_gene2617	6.961e-157	507.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,2K0U4@204457|Sphingomonadales	204457|Sphingomonadales	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HFD1_k127_7474876_4	1088721.NSU_1228	3.127e-94	324.0	COG3659@1|root,COG3659@2|Bacteria,1QMC3@1224|Proteobacteria,2TU5Q@28211|Alphaproteobacteria,2K193@204457|Sphingomonadales	204457|Sphingomonadales	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
HFD1_k127_7474876_6	1187851.A33M_3863	6.084e-29	121.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HFD1_k127_7474876_0	1123267.JONN01000001_gene2239	0.0	1197.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,2K0E4@204457|Sphingomonadales	204457|Sphingomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HFD1_k127_7521102_2	1123267.JONN01000002_gene124	2.757e-38	148.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria,2K5XM@204457|Sphingomonadales	204457|Sphingomonadales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HFD1_k127_7521102_0	1112214.AHIS01000095_gene800	6.794e-127	416.0	COG2267@1|root,COG2267@2|Bacteria,1MVDA@1224|Proteobacteria,2TUDQ@28211|Alphaproteobacteria,2K1MR@204457|Sphingomonadales	204457|Sphingomonadales	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
HFD1_k127_7521102_1	1123267.JONN01000002_gene120	2.606e-58	205.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,2K4GA@204457|Sphingomonadales	204457|Sphingomonadales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HFD1_k127_7555949_3	1123267.JONN01000001_gene2271	1.762e-70	247.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MXFM@1224|Proteobacteria,2TWYV@28211|Alphaproteobacteria,2K14T@204457|Sphingomonadales	204457|Sphingomonadales	H	Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_7555949_0	13689.BV96_01980	2.975e-187	593.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,2K101@204457|Sphingomonadales	204457|Sphingomonadales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HFD1_k127_7555949_1	392499.Swit_2530	2.497e-181	574.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,2K1M6@204457|Sphingomonadales	204457|Sphingomonadales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HFD1_k127_7555949_2	1030157.AFMP01000004_gene1980	1.11e-91	309.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,2K12S@204457|Sphingomonadales	204457|Sphingomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HFD1_k127_7555949_5	1123267.JONN01000001_gene2277	3.746e-38	150.0	COG5373@1|root,COG5373@2|Bacteria,1N7JV@1224|Proteobacteria,2TR7A@28211|Alphaproteobacteria,2K53N@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4167
HFD1_k127_7555949_4	1123267.JONN01000001_gene2280	2.06e-54	194.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria,2K591@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA hydrolase	-	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HFD1_k127_7555949_6	685778.AORL01000025_gene128	3.116e-06	54.0	2ACU7@1|root,312F7@2|Bacteria,1N510@1224|Proteobacteria,2UDTR@28211|Alphaproteobacteria,2K7QW@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7573982_2	1123267.JONN01000002_gene260	6.924e-21	93.0	2E2R2@1|root,32XTN@2|Bacteria,1NHQU@1224|Proteobacteria,2TVUG@28211|Alphaproteobacteria,2KE8A@204457|Sphingomonadales	204457|Sphingomonadales	S	MerC mercury resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MerC
HFD1_k127_7573982_1	1123267.JONN01000002_gene262	7.659e-69	236.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,2K4GM@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the Fur family	-	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
HFD1_k127_7573982_0	1123267.JONN01000002_gene265	0.0	1020.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,2K0XY@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HFD1_k127_7574606_3	1122962.AULH01000019_gene321	6.973e-14	72.0	COG0625@1|root,COG2227@1|root,COG0625@2|Bacteria,COG2227@2|Bacteria,1NE6Z@1224|Proteobacteria,2TVN6@28211|Alphaproteobacteria,36Y3K@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_C_3,GST_N
HFD1_k127_7574606_1	85643.Tmz1t_2016	2.246e-41	154.0	COG1917@1|root,COG1917@2|Bacteria,1RJX2@1224|Proteobacteria,2WGBY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_7574606_0	1348657.M622_10560	5.261e-179	567.0	COG1275@1|root,COG1275@2|Bacteria,1MXP2@1224|Proteobacteria,2VI6R@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Voltage-dependent anion channel	-	-	-	-	-	-	-	-	-	-	-	-	SLAC1
HFD1_k127_7574606_4	1134474.O59_001556	3.319e-13	74.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,1SI3D@1236|Gammaproteobacteria,1FHMH@10|Cellvibrio	1236|Gammaproteobacteria	M	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
HFD1_k127_7574606_2	1040989.AWZU01000011_gene4022	8.919e-25	104.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,3JWCZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HFD1_k127_7599636_7	1379701.JPJC01000276_gene567	1.887e-120	391.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TUFB@28211|Alphaproteobacteria,2K0FM@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HFD1_k127_7599636_5	1123240.ATVO01000008_gene2354	3.639e-147	478.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TRQ5@28211|Alphaproteobacteria,2K0GN@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the peptidase M24B family	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HFD1_k127_7599636_6	1123267.JONN01000002_gene239	5.419e-146	475.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,2K0JH@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HFD1_k127_7599636_1	745310.G432_18050	7.617e-200	627.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,2K1TR@204457|Sphingomonadales	204457|Sphingomonadales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HFD1_k127_7599636_3	685778.AORL01000001_gene135	3.126e-167	537.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria,2KCU9@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HFD1_k127_7599636_8	1123267.JONN01000002_gene353	2.225e-113	369.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,2JZX6@204457|Sphingomonadales	204457|Sphingomonadales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HFD1_k127_7599636_0	1502850.FG91_03844	0.0	1089.0	COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2TW6Q@28211|Alphaproteobacteria,2K1IJ@204457|Sphingomonadales	204457|Sphingomonadales	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HFD1_k127_7599636_4	1123267.JONN01000002_gene349	2.176e-149	478.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,2U0P8@28211|Alphaproteobacteria,2K007@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HFD1_k127_7599636_10	1380394.JADL01000001_gene2668	4.08e-69	245.0	COG0662@1|root,COG0662@2|Bacteria,1NX8W@1224|Proteobacteria,2TY4P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_7599636_2	1123267.JONN01000002_gene348	2.366e-194	622.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,2K02U@204457|Sphingomonadales	204457|Sphingomonadales	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HFD1_k127_7599636_12	1120963.KB894491_gene1107	2.146e-08	64.0	2DE24@1|root,2ZK69@2|Bacteria,1P9N5@1224|Proteobacteria,1SU0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7599636_9	1123267.JONN01000002_gene346	6.781e-74	254.0	2EAQM@1|root,334SV@2|Bacteria,1N39W@1224|Proteobacteria,2UE2Z@28211|Alphaproteobacteria,2K4QC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7599636_11	1123267.JONN01000002_gene345	2.844e-12	67.0	COG4783@1|root,COG4783@2|Bacteria,1RAJB@1224|Proteobacteria,2TRY3@28211|Alphaproteobacteria,2JZYT@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HFD1_k127_7619876_8	1123267.JONN01000001_gene2201	4.265e-86	287.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,2K0S9@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HFD1_k127_7619876_5	1123267.JONN01000001_gene2200	2.848e-137	448.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,2K0GB@204457|Sphingomonadales	204457|Sphingomonadales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HFD1_k127_7619876_4	1123267.JONN01000001_gene2198	1.793e-143	466.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2TSIA@28211|Alphaproteobacteria,2K0U7@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HFD1_k127_7619876_6	1123267.JONN01000001_gene2197	3.723e-105	353.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,2K1ZB@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HFD1_k127_7619876_2	1123267.JONN01000001_gene2196	5.256e-228	718.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,2K1RQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Heparinase	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
HFD1_k127_7619876_1	685778.AORL01000022_gene1653	7.863e-252	788.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2K0R5@204457|Sphingomonadales	204457|Sphingomonadales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HFD1_k127_7619876_3	1123267.JONN01000001_gene2194	5.472e-177	572.0	COG2244@1|root,COG2244@2|Bacteria,1PDRG@1224|Proteobacteria,2TVKM@28211|Alphaproteobacteria,2K0P5@204457|Sphingomonadales	204457|Sphingomonadales	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3
HFD1_k127_7619876_0	745310.G432_11300	0.0	1258.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2K1KW@204457|Sphingomonadales	204457|Sphingomonadales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HFD1_k127_7619876_7	1123267.JONN01000001_gene1221	1.446e-100	334.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2K40S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HFD1_k127_7619876_10	629773.AORY01000004_gene310	1.302e-09	63.0	2DNPG@1|root,32YEX@2|Bacteria,1NNRG@1224|Proteobacteria,2UKH6@28211|Alphaproteobacteria,2K45J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7642343_6	1112214.AHIS01000101_gene1620	5.827e-38	146.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2U0GU@28211|Alphaproteobacteria,2K459@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD1_k127_7642343_1	1287276.X752_22115	9.883e-158	506.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TUXP@28211|Alphaproteobacteria,43N4R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	beta-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42,Glycos_transf_1
HFD1_k127_7642343_3	317655.Sala_0737	9.72e-125	409.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,2UFF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43
HFD1_k127_7642343_0	745310.G432_17935	3.538e-243	757.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,2K11Z@204457|Sphingomonadales	204457|Sphingomonadales	I	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HFD1_k127_7642343_5	1123267.JONN01000001_gene1590	1.256e-43	164.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria,2K5JX@204457|Sphingomonadales	204457|Sphingomonadales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HFD1_k127_7642343_4	402881.Plav_3290	2.367e-47	175.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,1JP33@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Dehydroquinase class II	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HFD1_k127_7642343_7	685778.AORL01000010_gene2970	1.817e-23	106.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HFD1_k127_7642343_2	158500.BV97_02175	4.969e-140	450.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HFD1_k127_7642343_8	1038862.KB893854_gene17	4.872e-05	46.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,3JUR1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HFD1_k127_7864585_6	1123267.JONN01000001_gene2336	5.439e-35	134.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2K0T4@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HFD1_k127_7864585_5	1096930.L284_10660	1.308e-62	221.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,2K4ID@204457|Sphingomonadales	204457|Sphingomonadales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HFD1_k127_7864585_2	1123267.JONN01000001_gene2334	2.007e-123	401.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2K1V9@204457|Sphingomonadales	204457|Sphingomonadales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HFD1_k127_7864585_10	745310.G432_14215	1.997e-19	94.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2U9XK@28211|Alphaproteobacteria,2K4Y5@204457|Sphingomonadales	204457|Sphingomonadales	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
HFD1_k127_7864585_8	1123267.JONN01000001_gene2331	1.374e-28	115.0	COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria,2K5X3@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HFD1_k127_7864585_4	1123267.JONN01000001_gene2330	1.346e-77	266.0	COG1376@1|root,COG1376@2|Bacteria,1RKB2@1224|Proteobacteria,2UAA8@28211|Alphaproteobacteria,2K4DR@204457|Sphingomonadales	204457|Sphingomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD_2
HFD1_k127_7864585_1	1123267.JONN01000001_gene2329	3.686e-145	475.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
HFD1_k127_7864585_13	629773.AORY01000017_gene2873	0.000222	48.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_9,PilZ
HFD1_k127_7864585_7	1123267.JONN01000001_gene2324	2.184e-34	133.0	29188@1|root,2ZNVC@2|Bacteria,1NM5D@1224|Proteobacteria,2UMZG@28211|Alphaproteobacteria,2K7SH@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7864585_3	1123267.JONN01000001_gene2323	1.947e-111	367.0	COG0652@1|root,COG0652@2|Bacteria,1QCY4@1224|Proteobacteria,2U56N@28211|Alphaproteobacteria,2K25P@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
HFD1_k127_7864585_0	1123267.JONN01000001_gene2322	6.38e-178	565.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2TVIF@28211|Alphaproteobacteria,2K0X5@204457|Sphingomonadales	204457|Sphingomonadales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HFD1_k127_7864585_12	555217.Zmob_1234	1.125e-11	73.0	2ANHM@1|root,31DGD@2|Bacteria,1PBN5@1224|Proteobacteria,2UX1C@28211|Alphaproteobacteria,2K77Q@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7900026_4	1112214.AHIS01000036_gene1774	4.776e-26	109.0	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2U9QR@28211|Alphaproteobacteria,2K4JQ@204457|Sphingomonadales	204457|Sphingomonadales	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HFD1_k127_7900026_5	1123267.JONN01000002_gene123	4.739e-22	102.0	28RMB@1|root,2ZE02@2|Bacteria,1P04A@1224|Proteobacteria,2UV0Q@28211|Alphaproteobacteria,2K50J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7900026_1	1123267.JONN01000001_gene544	4.15e-122	399.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2TUHX@28211|Alphaproteobacteria,2K07X@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
HFD1_k127_7900026_0	194867.ALBQ01000059_gene3276	9.43e-220	697.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,2K0CE@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HFD1_k127_7900026_2	1219049.SP5_018_00910	6.525e-86	289.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,2K1YX@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HFD1_k127_7900026_3	1123240.ATVO01000006_gene1500	1.14e-43	164.0	COG0730@1|root,COG0730@2|Bacteria,1R6MR@1224|Proteobacteria,2URRK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
HFD1_k127_7947019_1	1126627.BAWE01000004_gene4114	1.102e-33	136.0	COG3467@1|root,COG3467@2|Bacteria,1RAZD@1224|Proteobacteria,2TXIF@28211|Alphaproteobacteria,3K6W8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HFD1_k127_7947019_2	1449076.JOOE01000004_gene339	2.203e-08	57.0	2BF46@1|root,328WD@2|Bacteria,1P8AF@1224|Proteobacteria,2UZ3D@28211|Alphaproteobacteria,2K84J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_7947019_0	13689.BV96_00560	7.081e-74	254.0	COG3577@1|root,COG3577@2|Bacteria,1R74B@1224|Proteobacteria,2U3DP@28211|Alphaproteobacteria,2KD6X@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
HFD1_k127_819738_5	194867.ALBQ01000011_gene348	3.757e-60	213.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,2K02Y@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speF	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HFD1_k127_819738_4	1394178.AWOO02000020_gene7439	6.865e-88	297.0	COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria,4EKYH@85012|Streptosporangiales	201174|Actinobacteria	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HFD1_k127_819738_3	1123267.JONN01000001_gene1097	2.645e-124	406.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2K27R@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HFD1_k127_819738_1	1123267.JONN01000001_gene1100	1.016e-131	422.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,2JZVR@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha Beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
HFD1_k127_819738_2	1123267.JONN01000001_gene1101	2.225e-129	424.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2JZZX@204457|Sphingomonadales	204457|Sphingomonadales	E	overlaps another CDS with the same product name	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD1_k127_819738_0	1123267.JONN01000001_gene1102	4.392e-141	466.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2K05P@204457|Sphingomonadales	204457|Sphingomonadales	E	overlaps another CDS with the same product name	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HFD1_k127_819738_6	685778.AORL01000021_gene386	7.172e-26	112.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,2K5X1@204457|Sphingomonadales	204457|Sphingomonadales	C	Ferredoxin	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HFD1_k127_837956_0	1123267.JONN01000001_gene1402	2.778e-169	535.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,2K08Q@204457|Sphingomonadales	204457|Sphingomonadales	E	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HFD1_k127_837956_2	745310.G432_04070	3.455e-107	353.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,2K1X9@204457|Sphingomonadales	204457|Sphingomonadales	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HFD1_k127_837956_4	1123267.JONN01000001_gene1400	4.918e-65	230.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2U7BZ@28211|Alphaproteobacteria,2K0BP@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HFD1_k127_837956_1	1123267.JONN01000001_gene1399	3.066e-144	475.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,2K08N@204457|Sphingomonadales	204457|Sphingomonadales	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HFD1_k127_837956_3	745310.G432_04045	4.083e-65	224.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,2K2HN@204457|Sphingomonadales	204457|Sphingomonadales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
HFD1_k127_842511_1	194867.ALBQ01000018_gene2591	9.655e-131	437.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2U35U@28211|Alphaproteobacteria,2K136@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HFD1_k127_842511_5	1123267.JONN01000001_gene1087	3.13e-53	196.0	COG1573@1|root,COG1573@2|Bacteria,1NC19@1224|Proteobacteria,2UFEQ@28211|Alphaproteobacteria,2K5KQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HFD1_k127_842511_0	1030157.AFMP01000041_gene1242	2.453e-282	880.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2K0PG@204457|Sphingomonadales	204457|Sphingomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
HFD1_k127_842511_2	1123267.JONN01000001_gene1089	3.85e-112	385.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,2K0KS@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19
HFD1_k127_842511_3	1123267.JONN01000001_gene1090	4.239e-98	328.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,2K1QE@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HFD1_k127_842511_4	1123267.JONN01000001_gene1091	1.045e-56	202.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,2K1P3@204457|Sphingomonadales	204457|Sphingomonadales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
HFD1_k127_892854_4	1123267.JONN01000001_gene1869	3.699e-42	159.0	COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,2TVBG@28211|Alphaproteobacteria,2K0J7@204457|Sphingomonadales	204457|Sphingomonadales	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HFD1_k127_892854_1	1123267.JONN01000001_gene1868	9.411e-149	478.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,2K0EJ@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HFD1_k127_892854_5	1366050.N234_03405	1.251e-21	96.0	2E3SC@1|root,32YPX@2|Bacteria,1N7IU@1224|Proteobacteria,2VWD1@28216|Betaproteobacteria,1K99S@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HFD1_k127_892854_3	291985.CCSI01000002_gene1706	6.307e-52	186.0	COG1917@1|root,COG1917@2|Bacteria,1RHWW@1224|Proteobacteria,2U97R@28211|Alphaproteobacteria,2KE5X@204457|Sphingomonadales	204457|Sphingomonadales	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HFD1_k127_892854_2	161528.ED21_18102	4.124e-60	214.0	COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2UBYV@28211|Alphaproteobacteria,2K5JS@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HFD1_k127_892854_0	1123267.JONN01000001_gene1864	1.315e-299	927.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,2K0TU@204457|Sphingomonadales	204457|Sphingomonadales	E	aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
HFD1_k127_939316_10	450851.PHZ_c0045	4.293e-57	202.0	2A23N@1|root,30QDW@2|Bacteria,1RGGT@1224|Proteobacteria,2U84G@28211|Alphaproteobacteria,2KK6N@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_939316_20	1549858.MC45_03750	3.564e-21	94.0	2FC5G@1|root,3449A@2|Bacteria,1NB1K@1224|Proteobacteria,2UFY7@28211|Alphaproteobacteria,2K6YG@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_939316_5	1123269.NX02_01560	1.022e-90	306.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2TRID@28211|Alphaproteobacteria,2K0IB@204457|Sphingomonadales	204457|Sphingomonadales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HFD1_k127_939316_21	745310.G432_17875	3.317e-20	92.0	COG0690@1|root,COG0690@2|Bacteria,1N75P@1224|Proteobacteria,2UF51@28211|Alphaproteobacteria,2K6WV@204457|Sphingomonadales	204457|Sphingomonadales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HFD1_k127_939316_24	1081640.AGFU01000014_gene2071	0.000186	48.0	2AKMT@1|root,31BE9@2|Bacteria,1P7K5@1224|Proteobacteria,2UWIH@28211|Alphaproteobacteria,2K776@204457|Sphingomonadales	204457|Sphingomonadales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HFD1_k127_939316_18	1094184.KWO_0108925	1.361e-28	123.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S5MD@1236|Gammaproteobacteria,1X7R8@135614|Xanthomonadales	135614|Xanthomonadales	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
HFD1_k127_939316_13	685778.AORL01000021_gene924	1.162e-43	168.0	2FDTI@1|root,345U8@2|Bacteria,1NJ6F@1224|Proteobacteria,2V4SS@28211|Alphaproteobacteria,2K6Q3@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HFD1_k127_939316_2	685778.AORL01000021_gene923	9.226e-132	432.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HFD1_k127_939316_14	685778.AORL01000021_gene922	6.371e-39	154.0	2ES5B@1|root,33JQ4@2|Bacteria,1NHPR@1224|Proteobacteria,2UN83@28211|Alphaproteobacteria,2K67H@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HFD1_k127_939316_8	685778.AORL01000021_gene921	5.39e-61	216.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2TVKC@28211|Alphaproteobacteria,2K4M1@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HFD1_k127_939316_4	1123487.KB892841_gene4301	1.077e-112	379.0	28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,2KW13@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HFD1_k127_939316_19	1122603.ATVI01000005_gene3661	6.598e-24	106.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,1SEV5@1236|Gammaproteobacteria,1X8UI@135614|Xanthomonadales	135614|Xanthomonadales	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HFD1_k127_939316_0	1123267.JONN01000001_gene1597	3.453e-296	922.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,2K0HU@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2
HFD1_k127_939316_11	1123267.JONN01000001_gene1596	8.659e-44	168.0	COG2137@1|root,COG2137@2|Bacteria,1N2EE@1224|Proteobacteria,2U96W@28211|Alphaproteobacteria,2K59F@204457|Sphingomonadales	204457|Sphingomonadales	S	Regulatory protein RecX	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HFD1_k127_939316_9	1123267.JONN01000001_gene1595	5.866e-61	216.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,2K4T8@204457|Sphingomonadales	204457|Sphingomonadales	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HFD1_k127_939316_16	13689.BV96_02513	2.694e-32	137.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,2K5JY@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HFD1_k127_939316_12	1123267.JONN01000001_gene1593	1.013e-43	163.0	COG3761@1|root,COG3761@2|Bacteria,1RHS3@1224|Proteobacteria,2U95G@28211|Alphaproteobacteria,2K5FH@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH ubiquinone oxidoreductase 17.2 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	NDUFA12
HFD1_k127_939316_6	1123267.JONN01000001_gene1592	1.809e-86	292.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,2K180@204457|Sphingomonadales	204457|Sphingomonadales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HFD1_k127_939316_15	94624.Bpet2482	4.888e-36	143.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2VWVP@28216|Betaproteobacteria,3T8YE@506|Alcaligenaceae	28216|Betaproteobacteria	P	ArsC family	-	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
HFD1_k127_939316_3	1123267.JONN01000001_gene2393	3.509e-130	432.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K19X@204457|Sphingomonadales	204457|Sphingomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HFD1_k127_939316_17	1030157.AFMP01000064_gene2191	1.056e-30	130.0	COG0810@1|root,COG0810@2|Bacteria,1NB5F@1224|Proteobacteria,2UJ8K@28211|Alphaproteobacteria,2KDGQ@204457|Sphingomonadales	204457|Sphingomonadales	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HFD1_k127_939316_1	1112214.AHIS01000101_gene1620	1.907e-160	510.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2U0GU@28211|Alphaproteobacteria,2K459@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HFD1_k127_992388_1	1123267.JONN01000001_gene1673	3.73e-69	235.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2K1F5@204457|Sphingomonadales	204457|Sphingomonadales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HFD1_k127_992388_0	1123267.JONN01000001_gene1672	4.904e-263	816.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2K1J3@204457|Sphingomonadales	204457|Sphingomonadales	C	E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
## 1991 queries scanned
## Total time (seconds): 128.12922739982605
## Rate: 15.54 q/s